text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
a profound fall in arterial pressure during anaesthesia induced with thiopentone has been demonstrated in previously reported patients with the shy-drager syndrome . | NA | {
"id": "C0020649",
"name": "fall in",
"pos": [
11,
18
]
} | {
"id": "C0037019",
"name": "shy-drager syndrome",
"pos": [
144,
163
]
} |
they suggest that cholesterin containing debris entering the subarachnoid space from the tumour cysts provoke an aseptic `` '' chemical '' '' meningitis of short course . | NA | {
"id": "C0027651",
"name": "tumour",
"pos": [
89,
95
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
96,
101
]
} |
the presence of fibronectin ( fn ) and glial fibrillary acidic protein ( gfap ) in two astrocytomas , 17 glioblastomas , and five meningiomas was studied by indirect immunoperoxidase staining of formalin-fixed and paraffin-embedded surgical specimens . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
87,
99
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
105,
118
]
} |
in astrocytomas and glioblastomas , gfap-positive tumor cells had no fn expression and fn was confined to proliferating vessel walls and the leptomeninges , showing a mutually exclusive fn and gfap expression . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
3,
15
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
20,
33
]
} |
further , absorption testing of the reactive sera on normal brain , well-differentiated astrocytoma and cultured glioblastoma cells , together with cross-reactivity experiments suggests that at least two antigens or groups of antigens are expressed on the glioma cell surface : one shared by well and poorly differentiat... | NA | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
88,
99
]
} | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
113,
125
]
} |
biochemical assay of 5'-nucleotidase activity in 35 tumours showed it to be clearly higher in malignant ( anaplastic astrocytomas and glioblastomas ) than in benign astrocytomas . | NA | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
134,
147
]
} | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
165,
177
]
} |
in addition to androstenedione , the basal peripheral levels of 17-hydroxyprogesterone and estrone were increased , being 5- and 3-fold the mean of the reference interval , respectively , whereas pregnenolone , progesterone , dehydroepiandrosterone , 5 alpha-dihydrotestosterone and estradiol concentrations were within ... | NA | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
64,
86
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
211,
223
]
} |
in this study , 35 healthy preterm infants with gestational age from 31 to 36 weeks and a birth weight less than 2200 g , were followed until they attained a weight of 2400 g at about 5 to 7 weeks of age . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
90,
102
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
158,
164
]
} |
qualitative differences between the inotropic responses in rat papillary muscles to alpha-adrenoceptor and beta-adrenoceptor stimulation by both noradrenaline and adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
145,
158
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
163,
173
]
} |
the volume of haemorrhage was significantly larger in the patients who died and 9/10 patients with a haematoma volume above 80 ml died . | NA | {
"id": "C0019080",
"name": "haemorrhage",
"pos": [
14,
25
]
} | {
"id": "C0018944",
"name": "haematoma",
"pos": [
101,
110
]
} |
excited state interactions of protoporphyrin ix and related porphyrins with molecular oxygen in solutions and in organized assemblies . | NA | {
"id": "C0033733",
"name": "protoporphyrin ix",
"pos": [
30,
47
]
} | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
60,
70
]
} |
one example of a rare complication at a later time , with palacos material perforating into the pelvis and subsequent intestinal obstructions ( ileus ) , is also presented . | NA | {
"id": "C0021843",
"name": "intestinal obstructions",
"pos": [
118,
141
]
} | {
"id": "C1258215",
"name": "ileus",
"pos": [
144,
149
]
} |
from our results , it appears that gentamicin is the aminoglycoside that induces the greatest number of lysosomal changes whereas amikacin induces the least , with the effects of netilmicin and tobramycin quite close to those of amikacin . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
35,
45
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
53,
67
]
} |
effects of bradykinin , some of its fragments , kallidin and various synthetic analogs on rat pmn chemotactic responsiveness . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
11,
21
]
} | {
"id": "C0022474",
"name": "kallidin",
"pos": [
48,
56
]
} |
there was a lower number of males than females in the group in whom the gender of the fetus could not be detected by sonography . | NA | {
"id": "C0086582",
"name": "males",
"pos": [
28,
33
]
} | {
"id": "C0079399",
"name": "gender",
"pos": [
72,
78
]
} |
sonograms of 73 patients with 92 hydronephrotic kidneys were prospectively reviewed in an attempt to differentiate hydronephrosis from pyonephrosis . | NA | {
"id": "C0020295",
"name": "hydronephrosis",
"pos": [
115,
129
]
} | {
"id": "C0034216",
"name": "pyonephrosis",
"pos": [
135,
147
]
} |
it is concluded that in patients with clinical suspicion of renal infection , sonography has a high degree of accuracy ( 96 % ) in the differentiation of pyonephrosis from hydronephrosis . | NA | {
"id": "C0034216",
"name": "pyonephrosis",
"pos": [
154,
166
]
} | {
"id": "C0020295",
"name": "hydronephrosis",
"pos": [
172,
186
]
} |
the relation between clinical evidence of and histologic signs of anthracycline cardiotoxicity was evaluated by reviewing the clinical and morphologic findings in 64 patients studied at necropsy , all of whom had received doxorubicin or daunorubicin chemotherapy during life . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
222,
233
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
237,
249
]
} |
we have explored the tin/zinc interaction using the change-in-plasma-zinc-concentration method with a standard dosage of 12.5 mg of zinc as zinc sulfate in 100 ml of coca-cola . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
25,
29
]
} | {
"id": "C0078794",
"name": "zinc sulfate",
"pos": [
140,
152
]
} |
clinical and epidemiologic data also suggest that a second heavy metal , lead , may operate almost interchangeably with mercury . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
59,
70
]
} | {
"id": "C0023175",
"name": "lead",
"pos": [
73,
77
]
} |
clinical and epidemiologic data also suggest that a second heavy metal , lead , may operate almost interchangeably with mercury . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
59,
70
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
120,
127
]
} |
the forensic and preventive-medical challenge is to identify , monitor , and resolve questions of hidden heavy metal hazards in a high technology society , especially those of lead and mercury . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
105,
116
]
} | {
"id": "C0023175",
"name": "lead",
"pos": [
176,
180
]
} |
the forensic and preventive-medical challenge is to identify , monitor , and resolve questions of hidden heavy metal hazards in a high technology society , especially those of lead and mercury . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
105,
116
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
185,
192
]
} |
eighteen of the shunt insertions ( 21 % ) were followed by a major infection -- eight bacteremias , eight peritonitis , and nine wound infections . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
67,
76
]
} | {
"id": "C0043241",
"name": "wound infections",
"pos": [
129,
145
]
} |
isoelectric focusing in polyacrylamide gels has been widely used to separate fetal ( hbf ) and adult ( hba ) hemoglobins , and the relative synthesis of hba and hbf has been estimated by fluorography or autography of dried gels . | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
109,
120
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
153,
156
]
} |
isoelectric focusing in polyacrylamide gels has been widely used to separate fetal ( hbf ) and adult ( hba ) hemoglobins , and the relative synthesis of hba and hbf has been estimated by fluorography or autography of dried gels . | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
109,
120
]
} | {
"id": "C0015936",
"name": "hbf",
"pos": [
161,
164
]
} |
the infertile men usually retain sexual function , whereas the infertile women experience premature menopause and sexual dysfunction . | NA | {
"id": "C0021359",
"name": "infertile",
"pos": [
4,
13
]
} | {
"id": "C0021361",
"name": "infertile women",
"pos": [
63,
78
]
} |
antibody and complement can function as opsonins and enhance the ability of polymorphonuclear leukocytes to engulf microbes . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0029122",
"name": "opsonins",
"pos": [
40,
48
]
} |
evaluation revealed the presence of an empty sella , hyperprolactinemia , and an isolated pituitary deficiency of acth , resulting in secondary adrenal insufficiency . | NA | {
"id": "C0014008",
"name": "empty sella",
"pos": [
39,
50
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
90,
99
]
} |
intradermal testing demonstrated biphasic reactions to a wide variety of insulin preparations except for two recently available purified single-component ( less than 1 ppm proinsulin ) insulins . | NA | {
"id": "C0356369",
"name": "biphasic",
"pos": [
33,
41
]
} | {
"id": "C3537244",
"name": "insulins",
"pos": [
185,
193
]
} |
within each dosing method group those patients receiving gentamicin and tobramycin had a similar mean age , initial serum creatinine level , total dose , duration of therapy and trough serum aminoglycoside concentration . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
57,
67
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
191,
205
]
} |
information about the natural history of genital hsv infections obtained from frequent third-trimester viral cultures can be used to manage pregnancy and will reduce the need for cesarean section while avoiding neonatal hsv morbidity . | NA | {
"id": "C0032981",
"name": "third-trimester",
"pos": [
87,
102
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
140,
149
]
} |
two groups of patients , one with a class ii , division 1 malocclusion and the other with a class iii malocclusion , were treated with the frankel appliance . | NA | {
"id": "C0024636",
"name": "malocclusion",
"pos": [
58,
70
]
} | {
"id": "C0399526",
"name": "class iii malocclusion",
"pos": [
92,
114
]
} |
light- and electron-microscopic examination showed no evidence of bronchitis and/or bronchiolitis or of physical obstruction to the terminal airways in the early development of fibrosis and emphysema . | NA | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
66,
76
]
} | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
84,
97
]
} |
the rise in blood glucose induced by mct feeding was not secondary to a decreased uptake of glucose by peripheral tissues because [ 6-3h ] glucose turnover rate was increased in mct-fed neonates . | NA | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
9,
25
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
139,
146
]
} |
in islets of newborn ( 5 days ) and adult ( 3 mo ) rats elevation of glucose produced an increase in insulin secretion , pentose phosphate shunt ( pps ) activity , and nadph/nadp , nadh/nad , and gsh/gssg ratios . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
196,
199
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
200,
204
]
} |
an increase in the nadh/nad ratio was also observed in islets of fetal rats , but in contrast to islets of newborns and adults no increase in insulin release , pps activity , and the gsh/gssg ratio was observed . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
183,
186
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
187,
191
]
} |
it is possible that the missing insulin release of fetal islets in response to glucose is at least in part due to the fact that the oxidation-reduction state of the gsh/gssg system also does not respond to the elevation of the glucose concentration . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
165,
168
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
169,
173
]
} |
we have studied the effects of hb 699 and the sulfonylurea glipizide on pancreatic polypeptide ( pp ) and insulin secretion in the dog . | NA | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
46,
58
]
} | {
"id": "C0017642",
"name": "glipizide",
"pos": [
59,
68
]
} |
the data reveal that a higher isoelectric point significantly enhances proximal tubular reabsorption of albumin , lysozyme , and cytochrome c and that proteins with similar molecular weight and isoelectric point are not necessarily reabsorbed to the same degree . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
104,
111
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
151,
159
]
} |
the rate of hco-3 absorption ( jhco-3 ) measured by ph-stat was high when the major anion was cl- , br- , i- , or so2- ( 4 ) but was lower when gluconate or benzene sulfonate ( so-3 ) was the anion . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
25,
26
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
192,
197
]
} |
further , the brain space of 125i-angiotensinogen was identical to that of 125i-albumin , a protein that does not partition from plasma into the central nervous system . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
80,
87
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
92,
99
]
} |
although the peak mean arterial pressure levels produced by ltc4 and ltd4 ( 135 +/- 7 and 129 +/- 5 mmhg , respectively ) were less than those by norepinephrine ( 157 +/- 3 mmhg ) and angiotensin ( 174 +/- 5 mmhg ) , the peak total peripheral resistance values of ltc4 and ltd4 ( 2.23 +/- 0.32 and 1.86 +/- 0.17 mmhg x m... | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
184,
195
]
} | {
"id": "C0003009",
"name": "angiotensin",
"pos": [
438,
449
]
} |
two patients with hemochromatosis , in which iron overload is postulated to exclude chromium transport , were found to have altered rate constants . | NA | {
"id": "C0018995",
"name": "hemochromatosis",
"pos": [
18,
33
]
} | {
"id": "C0282193",
"name": "iron overload",
"pos": [
45,
58
]
} |
comparison of the protective effect of ketotifen and disodium cromoglycate on exercise-induced asthma in asthmatic boys . | NA | {
"id": "C0004099",
"name": "exercise-induced asthma",
"pos": [
78,
101
]
} | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
105,
114
]
} |
comparison of the spectra obtained with those of a number of porphyrins used as standards ( protoporphyrin , uroporphyrin , and coproporphyrins ) shows that the autofluorescence excited at about 400 nm ( soret band ) is due to the presence of a mixture of these or other porphyrins in the nerve . | NA | {
"id": "C0033733",
"name": "protoporphyrin",
"pos": [
92,
106
]
} | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
271,
281
]
} |
comparison of the spectra obtained with those of a number of porphyrins used as standards ( protoporphyrin , uroporphyrin , and coproporphyrins ) shows that the autofluorescence excited at about 400 nm ( soret band ) is due to the presence of a mixture of these or other porphyrins in the nerve . | NA | {
"id": "C0042093",
"name": "uroporphyrin",
"pos": [
109,
121
]
} | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
271,
281
]
} |
comparison of the spectra obtained with those of a number of porphyrins used as standards ( protoporphyrin , uroporphyrin , and coproporphyrins ) shows that the autofluorescence excited at about 400 nm ( soret band ) is due to the presence of a mixture of these or other porphyrins in the nerve . | NA | {
"id": "C0009988",
"name": "coproporphyrins",
"pos": [
128,
143
]
} | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
271,
281
]
} |
concentrations of dopamine , norepinephrine , and epinephrine in the cn of ss pigs were significantly lower ( p less than 0.05 ) than those in the cn of sr pigs . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
29,
43
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
50,
61
]
} |
similarly , the sn of ss pigs had lower dopamine , norepinephrine , and epinephrine concentrations than did the sn of sr pigs . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
51,
65
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
72,
83
]
} |
the predominant liver disease was chronic active hepatitis in 93 patients or cirrhosis in 32 ; | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
16,
29
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
77,
86
]
} |
at conception , beclomethasone dipropionate was being used regularly during 38 pregnancies and was initiated during the first trimester in 4 other pregnancies . | NA | {
"id": "C0032979",
"name": "first trimester",
"pos": [
120,
135
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
147,
158
]
} |
by applying non-uniform magnetic fields across a section of the body , hydrogen nuclei in different elemental volumes in the section are tagged with different frequencies and their signals can be processed to give an image of the section . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
71,
79
]
} | {
"id": "C0013879",
"name": "elemental",
"pos": [
100,
109
]
} |
transtympanic electrocochleography ( ecog ) was performed on 32 normal ears , 40 ears affected by hair cell damage without any evidence of endolymphatic hydrops ( sensory damage ) and 44 ears affected by established meniere 's disease . | NA | {
"id": "C0206586",
"name": "endolymphatic hydrops",
"pos": [
139,
160
]
} | {
"id": "C0025281",
"name": "meniere 's disease",
"pos": [
216,
234
]
} |
( b ) that the change in weight for a given change in height also depends on pubertal status , and ( c ) that these relations vary with age so that chronological age should be taken into account when constructing weight-for-height standards . | NA | {
"id": "C0005911",
"name": "change in weight",
"pos": [
15,
31
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
213,
219
]
} |
hormone levels are expressed both as rates of excretion and as creatinine ratios and are compared with the values for adrenaline and noradrenaline previously measured in the same samples . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
118,
128
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
133,
146
]
} |
an organic cause of meige syndrome is supported by a high correlation with essential tremor and other movement disorders and by positive family history in some patients . | NA | {
"id": "C0270736",
"name": "essential tremor",
"pos": [
75,
91
]
} | {
"id": "C0026650",
"name": "movement disorders",
"pos": [
102,
120
]
} |
the gonococci isolated were notably resistant to penicillin , ampicillin , erythromycin , and tetracycline , whereas all of the strains were susceptible to the newer beta-lactam agents cefoxitin and spectinomycin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
49,
59
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
166,
177
]
} |
the effect of the antiviral agent 9- ( 2-hydroxyethoxymethyl ) guanine ( acyclovir ) on herpes simplex virus type 1 protein synthesis during virus replication was examined . | NA | {
"id": "C0018321",
"name": "guanine",
"pos": [
63,
70
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
73,
82
]
} |
comparison of concentrations of rifampin and a new rifamycin derivative , dl 473 , in canine bone . | NA | {
"id": "C0035608",
"name": "rifampin",
"pos": [
32,
40
]
} | {
"id": "C0035609",
"name": "rifamycin",
"pos": [
51,
60
]
} |
constant-infusion experiments were performed in 14 dogs to determine the penetration into bone of rifampin and a new c-3 substituted rifamycin , dl 473 . | NA | {
"id": "C0035608",
"name": "rifampin",
"pos": [
98,
106
]
} | {
"id": "C0035609",
"name": "rifamycin",
"pos": [
133,
142
]
} |
fourteen enkephalin-containing peptides ( ec peptides ) from beef adrenal medulla were isolated and sequenced , and the presence of a protein that contained several [ met ] enkephalin sequences and one of [ leu ] enkephalin was demonstrated . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
9,
19
]
} | {
"id": "C0014295",
"name": "met ] enkephalin",
"pos": [
167,
183
]
} |
fourteen enkephalin-containing peptides ( ec peptides ) from beef adrenal medulla were isolated and sequenced , and the presence of a protein that contained several [ met ] enkephalin sequences and one of [ leu ] enkephalin was demonstrated . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
9,
19
]
} | {
"id": "C0014294",
"name": "leu ] enkephalin",
"pos": [
207,
223
]
} |
pancreatic porcine phospholipase a2 catalyzed hydrolysis of phosphatidylcholine in lecithin-bile salt mixed micelles : kinetic studies in a lecithin-sodium cholate system . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
60,
79
]
} | {
"id": "C0031617",
"name": "lecithin",
"pos": [
140,
148
]
} |
pancreatic porcine phospholipase a2 catalyzed hydrolysis of phosphatidylcholine in bile salt lecithin mixed micelles has been studied , utilizing a series of assay mixtures for which the micellar size , weight , and composition had been experimentally determined . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
60,
79
]
} | {
"id": "C0031617",
"name": "lecithin",
"pos": [
93,
101
]
} |
gtp , but not gpp ( nh ) p , was more efficient and persistent in activating adenylate cyclase in membranes from iap-treated cells than membranes from control cells . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
0,
3
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
14,
26
]
} |
gtp and gpp ( nh ) p caused marked inhibition of adenylate cyclase when the enzyme system was converted to its highly activated state by cholera toxin treatment or fluoride addition , presumably as a result of their interaction with the specific binding protein which is responsible for inhibition of adenylate cyclase . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
0,
3
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
8,
20
]
} |
nonheme proteins exhibited both cross-linking and radioactive labeling upon peroxide treatment in the presence but not the absence of heme protein or free hemin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
8,
16
]
} | {
"id": "C0018974",
"name": "heme protein",
"pos": [
134,
146
]
} |
these results indicate that adventitious peroxidase activity expressed by oxygen carrying and electron transport proteins yields active oxygen species that can damage these heme proteins and nearby macromolecules , a possible biochemical mechanism for the lethal and other deleterious intracellular effects of peroxide . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
113,
121
]
} | {
"id": "C0018974",
"name": "heme proteins",
"pos": [
173,
186
]
} |
enhancement was produced by folate compounds and p-amino-benzoylglutamate , small monovalent ( e.g. , cl- , acetate , and lactate ) and divalent ( e.g. , phosphate and succinate ) anions , a few nucleotides ( e.g. , amp ) , and thiamine pyrophosphate , while little or no effect was associated with trivalent anions ( e.... | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
154,
163
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
374,
380
]
} |
castanospermine ( 1,6,7,8-tetrahydroxyoctahydroindolizine ) was tested against a variety of commercially available glycosidases and found to be a potent inhibitor of almond emulsin beta-glucosidase , and also to inhibit fungal beta-xylosidase . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
115,
127
]
} | {
"id": "C0017764",
"name": "glucosidase",
"pos": [
186,
197
]
} |
it had an apparent mr of 60,000 by sephadex g-100 and sodium dodecyl sulfate ( sds ) -polyacrylamide gel electrophoresis , and a maximum activity for octanoyl-coa with acetyl-coa and palmitoyl-coa having activities of 2 and 10 % , respectively , when 100 microm acyl-coa substrates were used . | NA | {
"id": "C0001026",
"name": "acetyl-coa",
"pos": [
168,
178
]
} | {
"id": "C0001374",
"name": "acyl-coa",
"pos": [
262,
270
]
} |
it had an apparent mr of 60,000 by sephadex g-100 and sodium dodecyl sulfate ( sds ) -polyacrylamide gel electrophoresis , and a maximum activity for octanoyl-coa with acetyl-coa and palmitoyl-coa having activities of 2 and 10 % , respectively , when 100 microm acyl-coa substrates were used . | NA | {
"id": "C0030239",
"name": "palmitoyl-coa",
"pos": [
183,
196
]
} | {
"id": "C0001374",
"name": "acyl-coa",
"pos": [
262,
270
]
} |
time course studies indicated that with thymidine and 8-bromoadenine as substrates the 3-deoxyribonucleoside is initially the major product , but that the 9-deoxyribonucleoside becomes the major product after long incubation periods . | NA | {
"id": "C0040077",
"name": "thymidine",
"pos": [
40,
49
]
} | {
"id": "C0011528",
"name": "deoxyribonucleoside",
"pos": [
157,
176
]
} |
effects of ph on the ligand-binding reactions of ferric heme in cytochrome p-450 from pseudomonas putida ( camphor 5-monooxygenase , ec 1.14.15.1 ) were studied by using cyanide , n-methylimidazole , pyridine , and ethylisocyanide as ligands . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
64,
80
]
} | {
"id": "C0054563",
"name": "camphor 5-monooxygenase",
"pos": [
107,
130
]
} |
the proteases were nitro-alpha-thrombin , a derivative with nitrated tyrosine , gamma-thrombin , a product of partial proteolysis of alpha-thrombin , and trypsin , a homologous protease . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
4,
13
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
177,
185
]
} |
it was concluded that the action of polylysine on photosystem i and on the chlorophyll proteins is mediated by changes of the electrical properties of the thylakoid membrane and may not involve a direct binding of the polycation to the affected membrane proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
87,
95
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
245,
262
]
} |
connective tissue panniculitis and focal lipoatrophy may be forms of immunoreactive panniculitis or connective tissue disease ( or both ) in which typical microscopic , serologic , or other events related to classic connective tissue disease have not occurred . | NA | {
"id": "C0030326",
"name": "panniculitis",
"pos": [
18,
30
]
} | {
"id": "C0009782",
"name": "connective tissue disease",
"pos": [
216,
241
]
} |
lipid and lipoprotein tests other than cholesterol are not generally needed , although high-density lipoprotein cholesterol may be useful in certain situations . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
0,
5
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
100,
111
]
} |
systemic lupus erythematosus ( sle ) was seen in a patient with oculocutaneous albinism and platelet storage pool disease ( hermansky pudlak syndrome ) . | NA | {
"id": "C0078918",
"name": "oculocutaneous",
"pos": [
64,
78
]
} | {
"id": "C0079504",
"name": "hermansky pudlak syndrome",
"pos": [
124,
149
]
} |
increased urinary protein and albumin excretion was noted in the rats receiving carbon tetrachloride after ten weeks . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
18,
25
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
30,
37
]
} |
gay and heterosexual males were found to differ strongly in cross-gender characteristics during childhood but considerably less so during adulthood . | NA | {
"id": "C0086582",
"name": "males",
"pos": [
21,
26
]
} | {
"id": "C0079399",
"name": "gender",
"pos": [
66,
72
]
} |
an autoimmune mechanism may have been responsible for the retinal degeneration in this patient , and such a hypothesis raises questions about ( 1 ) autoimmune mechanisms in patients with retinitis pigmentosa and other retinal degenerative diseases and ( 2 ) autoimmune mechanisms in other cases of remote effects of carc... | NA | {
"id": "C0035304",
"name": "retinal degeneration",
"pos": [
58,
78
]
} | {
"id": "C0035309",
"name": "retinal",
"pos": [
218,
225
]
} |
comparison with the uninvolved fellow eyes showed that preoperative refractive errors were usually shifted toward hyperopia with intraconal tumors , whereas extraconal tumors were typically associated with higher astigmatic errors on the involved side . | NA | {
"id": "C0034951",
"name": "refractive errors",
"pos": [
68,
85
]
} | {
"id": "C0020490",
"name": "hyperopia",
"pos": [
114,
123
]
} |
bromocriptine mesylate ( 2-bromo-alpha-ergocryptine ) has proved to be useful in reducing the size of prolactin-secreting pituitary adenomas , but little evidence has accumulated about its effectiveness within the first two weeks of therapy . | NA | {
"id": "C0546852",
"name": "bromocriptine mesylate",
"pos": [
0,
22
]
} | {
"id": "C0006230",
"name": "2-bromo-alpha-ergocryptine",
"pos": [
25,
51
]
} |
no substantial differences were found between gentamicin and the newer aminoglycoside , tobramycin , and the `` '' fortified '' '' preparations of these two drugs did not seem to be more toxic than the 0.3 % solutions . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
46,
56
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
71,
85
]
} |
under the incubation conditions for cholesterol esterifying activity , however , the bulk of the fatty acid was actively incorporated into phospholipid rather than cholesteryl ester or triglyceride . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
36,
47
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
164,
181
]
} |
acid-acetone fractionation of myoglobin into heme and globin , and subsequent precipitation of the heme , localized hormone binding to the heme moiety . | NA | {
"id": "C0027078",
"name": "myoglobin",
"pos": [
30,
39
]
} | {
"id": "C0017645",
"name": "globin",
"pos": [
54,
60
]
} |
when aligned for optimal homology to the trypsin related proteases , the insect endopeptidase displays 37 % identity with bovine chymotrypsin . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
57,
66
]
} | {
"id": "C0030946",
"name": "endopeptidase",
"pos": [
80,
93
]
} |
adenylate cyclase in homogenates of guinea pig ventricles was inhibited by the stable adenosine analogs n6-phenylisopropyladenosine ( pia ) and 5 ( 1 ) -n-ethylcarboxamidoadenosine ( neca ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
86,
95
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
107,
131
]
} |
adenylate cyclase in homogenates of guinea pig ventricles was inhibited by the stable adenosine analogs n6-phenylisopropyladenosine ( pia ) and 5 ( 1 ) -n-ethylcarboxamidoadenosine ( neca ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
86,
95
]
} | {
"id": "C0050789",
"name": "n-ethylcarboxamidoadenosine",
"pos": [
153,
180
]
} |
measurement of membrane ion flux at 25 mv external potential with buffered kcl electrolyte was performed for the receptor support matrix and various combinations of atp , receptor and naphthalene-1-acetic acid . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
24,
27
]
} | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
79,
90
]
} |
in order to further investigate the coordinate action of pro-corticotropin/endorphin-derived peptides on adrenal steroidogenesis , we have evaluated the effects of highly specific antisera to synthetic rat gamma 3-msh ( 1-27 ) peptide ( gamma 3-msh ab ) on corticosterone , 18-hydroxycorticosterone and aldosterone respo... | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
257,
271
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
274,
298
]
} |
dce caused a reduction of cytochrome p-450 levels and related monooxygenases in lung microsomes with no corresponding changes in liver and kidney . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
26,
42
]
} | {
"id": "C0003927",
"name": "monooxygenases",
"pos": [
62,
76
]
} |
myristoyl coa also inhibited dna polymerase alpha and gamma , while coenzyme a , short chain fatty acyl coa 's , na-myristate and na-palmitate failed to inhibit the enzymes . | NA | {
"id": "C0009226",
"name": "coenzyme a",
"pos": [
68,
78
]
} | {
"id": "C0001374",
"name": "fatty acyl coa 's",
"pos": [
93,
110
]
} |
using high resolution two-dimensional gel electrophoresis , we analyzed the intracellular and the released protein patterns of skin fibroblasts from hd patients and compared them to cells from apparently normal individuals matched for age and sex . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
132,
143
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
182,
187
]
} |
competition experiments showed that factor ix and factor ixa bind to the same sites , which are different from the factor x binding sites . | NA | {
"id": "C0015491",
"name": "factor ix",
"pos": [
36,
45
]
} | {
"id": "C0015494",
"name": "factor ixa",
"pos": [
50,
60
]
} |
reaction of such extracts with carbohydrate haptens demonstrated that the specificity of the binding was towards 4-o-methyl-d-glucuronic acid , d-glucuronic acid and their methyl glycosides . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
31,
43
]
} | {
"id": "C0017977",
"name": "glycosides",
"pos": [
179,
189
]
} |
fast atom bombardment mass spectrometry following hydrogen -- deuterium exchange in [ hydroxy-2h3 ] glycerol and 2h20 has been studied as a means of establishing active hydrogen content in molecules of unknown structure . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
62,
71
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
169,
177
]
} |
sodium hyaluronate from rooster comb , umbilical cord , bovine vitreous and a special commercial hyaluronic acid preparation , `` '' healonr '' '' have been fractionated at 4 degrees c on deae-sephacel columns using salt gradients from 0 leads to 0.4m nacl . | NA | {
"id": "C0087000",
"name": "sodium hyaluronate",
"pos": [
0,
18
]
} | {
"id": "C0020196",
"name": "hyaluronic acid preparation",
"pos": [
97,
124
]
} |
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