text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the protein as well as the lectin derivative blocked platelet aggregation by thrombin while aggregation induced by several other agents was unchanged . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
27,
33
]
} |
nucleic acid sequence analysis revealed that apoa-i mrna codes for a precursor apolipoprotein , preproapoa-i , which contains 24 amino acids on the nh2-terminal end of the mature plasma apoa-i . | NA | {
"id": "C0003592",
"name": "a",
"pos": [
8,
9
]
} | {
"id": "C0085201",
"name": "apoa-i",
"pos": [
186,
192
]
} |
regional distribution of the mr 15,000 somatostatin precursor , somatostatin-28 and somatostatin-14 in the rat brain suggests a differential intracellular processing of the high molecular weight species . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
64,
79
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
84,
99
]
} |
the gestational profiles of hepatic and pulmonary benzo ( a ) pyrene hydrolase , and epoxide hydrolase were similar in both strains . | NA | {
"id": "C0020289",
"name": "hydrolase",
"pos": [
69,
78
]
} | {
"id": "C0014628",
"name": "epoxide hydrolase",
"pos": [
85,
102
]
} |
the results obtained thus indicate that induction by ethanol of p-450 isozyme 3a ( or a homologous enzyme in other species ) may contribute to the toxicity of acetaminophen but that other cytochromes also play a significant role . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
70,
77
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
99,
105
]
} |
in protein free incubation mixtures binding was saturable , inhibited by excess cold oleate , virtually abolished by heat denaturation of the membranes , reversible by post-incubation with cold oleate or albumin , and ph and temperature dependent . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
3,
10
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
204,
211
]
} |
it depresses the rise of blood glucose when it is orally administered to glucose-loaded mice , rats and beagle dogs at minimal doses of 1 , 10 and 2.5 mg/kg , respectively . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
25,
38
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
73,
80
]
} |
the nitroimidazole misonidazole ( miso ) and related compounds have been shown to enhance the response of tumours to cytotoxic agents , and often to improve their therapeutic indices . | NA | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
4,
18
]
} | {
"id": "C0026218",
"name": "misonidazole",
"pos": [
19,
31
]
} |
two series of local anaesthetics were tested : procaine and its derivatives ( proxymetacaine , oxybuprocaine , butacaine and tetracaine ) had no ( or very slight ) porphyrogenic effects . | NA | {
"id": "C0033218",
"name": "procaine",
"pos": [
47,
55
]
} | {
"id": "C0053114",
"name": "oxybuprocaine",
"pos": [
95,
108
]
} |
nocap rapidly reacted with gsh with the formation of hydroxylamino-chloramphenicol ( nhohcap ) , d- ( - ) -threo-1- ( p-hydroxylaminophenyl ) -2-dichloroacetamido-1,3-propanediol and glutathione disulfide ( gssg ) . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
27,
30
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
207,
211
]
} |
the labile intermediate either isomerized to the sulfinamide , gsonhcap ( favoured by decreasing ph at constant gsh ) , or it was thiolytically cleaved by another gsh molecule to nhohcap and gssg ( favoured by increasing gsh at constant ph ) . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
191,
195
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
221,
224
]
} |
bestatin was found to be a competitive inhibitor ( with respect to the leu-na substrate ) not only of the isolated microsomal and cytosolic leucine aminopeptidases ( leu-apm and leu-apc ) but also of the aminopeptidases ( aps ) present in membrane preparations ( from mouse liver ) and on the cell surface of l5178y cell... | NA | {
"id": "C0023402",
"name": "leucine",
"pos": [
140,
147
]
} | {
"id": "C0002570",
"name": "aminopeptidases",
"pos": [
204,
219
]
} |
the motor area of the cerebral cortex was analyzed for glycolytic metabolites , related amino acids , energy mediators , fatty acids , phospholipids and free fatty acids . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
121,
132
]
} | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
153,
169
]
} |
during this condition , the intracarotid perfusion with some biological pyrimidines ( uridine , cytidine ) interfered with the glycolytic and amino acid metabolites , inducing a decrease in glucose , pyruvate and lactate contents , and an increase in succinate , alanine and glutamine cerebral concns . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
142,
152
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
263,
270
]
} |
this may have been due to the rapid metabolism and excretion of cpz in the rat when compared to humans . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
36,
46
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
51,
60
]
} |
methanol ( 5-200 mm ) and low concentrations of ethanol ( 5-25 mm ) enhanced the na+-dependent ca2+ influx measured at 23 degrees . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
0,
8
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
48,
55
]
} |
the products , l-glutamic acid and l-aspartic acid , showed competitive inhibition with respect to either l-glutamine or l-asparagine as substrates . | NA | {
"id": "C0061472",
"name": "l-glutamic acid",
"pos": [
15,
30
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
108,
117
]
} |
the kinetic data suggest an ordered mechanism with glutamine or asparagine as the first substrate and glutamic acid or aspartic acid , respectively , as the last product . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
51,
60
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
102,
115
]
} |
the present finding , that acute or chronic glucocorticoid-induced increases in in vivo tpo activity were rapidly blocked by intragastric carbohydrate loads , is consistent with the view that dietary carbohydrates modulate hepatic tpo activity via feedback repression and not by a cessation of tpo enzyme synthesis . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
138,
150
]
} | {
"id": "C0012170",
"name": "dietary",
"pos": [
192,
199
]
} |
survey of plant inhibitors of polymorphonuclear leukocyte elastase , pancreatic elastase , cathepsin g , cathepsin b , hageman factor fragments , and other serine proteinases . | NA | {
"id": "C0064833",
"name": "polymorphonuclear leukocyte elastase",
"pos": [
30,
66
]
} | {
"id": "C0030306",
"name": "pancreatic",
"pos": [
69,
79
]
} |
observations under electron microscope demonstrated that the main cells participating in the cartilage destruction at the cartilage-pannus junction were either fibroblast-like or macrophage-like cells , and suggested the possibility that these two types of cells were derived from synovial type a and type b cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
66,
71
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
160,
170
]
} |
the results are summarized of 13 published investigations of the beta-blocker 5- ( 3-tert-butylamino-2-hydroxy-propoxy ) -3 , 4-dihydro-2 ( 1h ) -quinolinone hydrochloride ( carteolol hydrochloride , endak , endak mite ) with a total of 378 patients suffering from cardiac rhythm irregularities ( tachycardias , extrasys... | NA | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
312,
325
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
335,
346
]
} |
to test whether ldl receptor activity is influenced by cyclic amp , the effect of dibutyryl cyclic amp on ldl binding uptake and degradation was studied in cultured human skin fibroblasts and in rat and human arterial smooth muscle cells . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
55,
65
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
82,
102
]
} |
this component closely resembled in amino acid composition the non-albumin moiety of the serum albumin complex , suggesting that this low molecular weight , gamma-carboxyglutamic acid-containing protein component was present in the calcified matrix both in the free form and in association with human serum albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
67,
74
]
} | {
"id": "C0036773",
"name": "albumin",
"pos": [
307,
314
]
} |
this component closely resembled in amino acid composition the non-albumin moiety of the serum albumin complex , suggesting that this low molecular weight , gamma-carboxyglutamic acid-containing protein component was present in the calcified matrix both in the free form and in association with human serum albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
67,
74
]
} | {
"id": "C0304925",
"name": "human serum",
"pos": [
295,
306
]
} |
these findings suggest defective conversion of vldl to ldl in crf , allowing for the accumulation of lipoprotein particles usually absent from plasma . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
47,
51
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
101,
112
]
} |
the free and esterified cholesterol contents in the lipoproteins were decreased with the very low density lipoproteins most affected ( -85 % ) . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
52,
64
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
89,
118
]
} |
lipid absorption was studied in non-fasting thoracic lymph duct-cannulated rats receiving continuous intraduodenal infusions of oils varying in triglyceride fatty acid saturation ( p/s = 4.6 or 0.2 ) , triglyceride load ( 66 or 165 mumoles/h ) and cholesterol load ( 0 and 3.5 mumoles/h at the low oil infusion rate , an... | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
0,
5
]
} | {
"id": "C0028908",
"name": "oils",
"pos": [
128,
132
]
} |
in this group , all subjects presented a poor general condition , with fever and immunological disorders ( hypo- or hypergammaglobulinemia , often monoclonal gammopathy ) . | NA | {
"id": "C0020455",
"name": "hypergammaglobulinemia",
"pos": [
116,
138
]
} | {
"id": "C0026470",
"name": "monoclonal gammopathy",
"pos": [
147,
168
]
} |
the ces lines differed in base-level responsiveness to distilled water ( and to saline ) as well as in response levels for w-ces and for sucrose-induced ces , which suggests the existence of genetic correlates for several components of the proboscis extension reflex . | NA | {
"id": "C0790233",
"name": "distilled water",
"pos": [
55,
70
]
} | {
"id": "C0043047",
"name": "w-ces",
"pos": [
123,
128
]
} |
the implications of the changes in the nature of the urinary proteins which occur in albumin overload-induced proteinuria in normal mice . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
61,
69
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
85,
92
]
} |
on addition of adenosine 5'-triphosphate ( atp ) or adenosine 5'-diphosphate ( adp ) at 25 degrees c , the dimeric form of the enzyme aggregated to tetrameric forms ( mr 242 000 and mr 230 000 , respectively ) , whereas addition of adenosine 5'-monophosphate had little effect on enzyme association ( mr 145 000 ) . | NA | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
15,
26
]
} | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
232,
243
]
} |
on addition of adenosine 5'-triphosphate ( atp ) or adenosine 5'-diphosphate ( adp ) at 25 degrees c , the dimeric form of the enzyme aggregated to tetrameric forms ( mr 242 000 and mr 230 000 , respectively ) , whereas addition of adenosine 5'-monophosphate had little effect on enzyme association ( mr 145 000 ) . | NA | {
"id": "C0001459",
"name": "adenosine 5",
"pos": [
15,
26
]
} | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
232,
243
]
} |
the cysteine oxidase is an iron-containing dioxygenase with a molecular weight of 10500 ( +/- 1500 ) and is present only in the yeast phase of the fungus . | NA | {
"id": "C0056872",
"name": "cysteine oxidase",
"pos": [
4,
20
]
} | {
"id": "C0599874",
"name": "dioxygenase",
"pos": [
43,
54
]
} |
the temperature dependence of the hydrogen-tritium and deuterium-hydrogen exchange reactions in poly ( dl-alanine ) has been reexamined . | NA | {
"id": "C0041119",
"name": "tritium",
"pos": [
43,
50
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
65,
73
]
} |
the temperature dependence of the hydrogen-tritium and deuterium-hydrogen exchange reactions in poly ( dl-alanine ) has been reexamined . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
55,
64
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
65,
73
]
} |
the activation enthalpy for water-catalyzed deuterium-hydrogen exchange in poly ( dl-alanine ) is found to be 21 kcal mol-1 . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
44,
53
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
54,
62
]
} |
the importance of water catalysis in protein hydrogen exchange is demonstrated by a reanalysis of data for the exchange of single protons in bovine pancreatic trypsin inhibitor [ hilton , b.d. , & woodward , c. k. ( 1979 ) biochemistry 18 , 5834 ; richarz , r. , sehr , p. , wagner , g. , & wuthrich , k. ( 1979 ) j. mol... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
37,
44
]
} | {
"id": "C0003641",
"name": "bovine pancreatic trypsin inhibitor",
"pos": [
141,
176
]
} |
in addition , tcrna102 does not associate with ribosomal rna or globin mrna , suggesting that some degree of specificity is involved with the rna-rna interactions . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
47,
60
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
146,
149
]
} |
reactivity of bovine blood coagulation factor ixa beta , factor xa beta , and factor xia toward fluorogenic peptides containing the activation site sequences of bovine factor ix and factor x . | NA | {
"id": "C0015494",
"name": "blood coagulation factor ixa",
"pos": [
21,
49
]
} | {
"id": "C0015491",
"name": "factor ix",
"pos": [
168,
177
]
} |
reactivity of bovine blood coagulation factor ixa beta , factor xa beta , and factor xia toward fluorogenic peptides containing the activation site sequences of bovine factor ix and factor x . | NA | {
"id": "C0015520",
"name": "factor xa",
"pos": [
57,
66
]
} | {
"id": "C0015518",
"name": "factor x",
"pos": [
182,
190
]
} |
various guanine nucleotides ( 10 microm ) including gmp , gdp , and gtp also specifically increased rhodopsin phosphorylation ( up to 5-fold ) . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
8,
27
]
} | {
"id": "C0018346",
"name": "gmp",
"pos": [
52,
55
]
} |
various guanine nucleotides ( 10 microm ) including gmp , gdp , and gtp also specifically increased rhodopsin phosphorylation ( up to 5-fold ) . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
8,
27
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
58,
61
]
} |
various guanine nucleotides ( 10 microm ) including gmp , gdp , and gtp also specifically increased rhodopsin phosphorylation ( up to 5-fold ) . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
8,
27
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
68,
71
]
} |
adenine nucleotides ( cyclic amp , amp , and adp at 10 microm ) and 8-bromo-gmp ( 10 microm ) or cyclic 8-bromo-gmp ( 10 microm ) had no detectable stimulatory effect on rhodopsin phosphorylation . | NA | {
"id": "C0001413",
"name": "adenine",
"pos": [
0,
7
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
22,
32
]
} |
transphosphorylation of guanine nucleotides by [ 32p ] atp and subsequent utilization of [ 32p ] gtp as a more effective substrate were ruled out as an explanation for the guanine nucleotide stimulation . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
97,
100
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
172,
190
]
} |
the trna , with essentially all its uracil and uracil-derived minor bases replaced by fura , was purified by sequential chromatography , first on diethylaminoethylcellulose ( deae-cellulose ) , at ph 8.9 , followed by chromatography on sepharose 4b , using a reverse salt gradient , then on deae-sephadex a-50 , and fina... | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
36,
42
]
} | {
"id": "C0016360",
"name": "fura",
"pos": [
86,
90
]
} |
the amino acid sequence of the alpha-chain domain supported previous indications that there is a strong selective pressure to maintain glycine as every third amino acid and to maintain a prescribed distribution of charged amino acids . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
135,
142
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
222,
233
]
} |
glycophorin from the human erythrocyte membrane has been isolated in pure form and reconstituted into large unilamellar vesicles comprised of binary mixtures of 1,2-dipalmitoyl-3-sn-phosphatidylcholine ( dppc ) and chain perdeuterated 1,2-dimyristoyl-3-sn-phosphatidylcholine ( dmpc-d54 ) . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
182,
201
]
} | {
"id": "C0012456",
"name": "dmpc",
"pos": [
278,
282
]
} |
the effect of protein is more pronounced on the dppc component than on the dmpc-d54 . | NA | {
"id": "C1959616",
"name": "dppc",
"pos": [
48,
52
]
} | {
"id": "C0012456",
"name": "dmpc",
"pos": [
75,
79
]
} |
the lack of removal of ct as well as tt observed in xeroderma pigmentosum fibroblasts indicates that the repair deficiency in these cells affects the repair of both classes of dimers . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
74,
85
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
146,
149
]
} |
the decrease in respiration rate following thyroidectomy is preceded by changes in the lipid composition of the mitochondrial membrane ( hoch , f.l. , subramanian , c. , dhopeshwarkar , g.a . and mead , j.f . ( 1981 ) lipids 16 , 328-334 ) and in concert , changes in the kinetic parameters of the adenine nucleotide tra... | NA | {
"id": "C0025249",
"name": "lipid",
"pos": [
87,
92
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
218,
224
]
} |
two ca2+-dependent atpase components were found in a plasma membrane fraction : a high affinity component ( half-saturation constant for ca2+ of 280 nm , vmax of 13.5 nmol/mg per min ) and a low affinity component , which was in reality a divalent cation atpase , since mg2+ could replace ca2+ without loss of activity . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
4,
7
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
255,
261
]
} |
uranyl ions ( uo2+ ( 2 ) ) and lanthanide cations ( la3+ , nd3+ , sm3+ , eu3+ , tb3+ and dy3+ ) at 100-200 microm concentration inhibited active transport of ca2+ , mediated by respiratory linked substrates as well as by atp hydrolysis , without affecting respiration and membrane-bound atpase activity , in inside-out m... | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
7,
11
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
42,
49
]
} |
the extent of inhibition in the uptake of ca2+ , mediated by atp hydrolysis , increased with increase in ionic radii of these cations . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
105,
110
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
126,
133
]
} |
it is proposed that inhibition in the uptake of ca2+ by uranyl ion occurs as a result of uo2+ ( 2 ) transport into the interior of vesicles in exchange for protons , while lanthanide cations are not being transported but affect the binding of ca2+ to the membrane , presumably to the ca2+/h+ antiporter . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
27,
30
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
183,
190
]
} |
the lipid class composition of membranes containing the c20-diacetylene lipids was examined and found to be similar to membranes from cells grown on oleic acid-containing medium . | NA | {
"id": "C0025249",
"name": "lipid",
"pos": [
4,
9
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
72,
78
]
} |
ligands which inhibited the k+-dependent p-nitrophenyl phosphate hydrolysis ( na+ , nucleotide polyphosphates , inorganic phosphate ) protected against inhibition by vanadate . | NA | {
"id": "C0032575",
"name": "polyphosphates",
"pos": [
95,
109
]
} | {
"id": "C0031603",
"name": "inorganic",
"pos": [
112,
121
]
} |
to compare acetylcholinesterase ( acetylcholine acetylhydrolase , ec 3.1.1.7 ) and butyrylcholinesterase ( acylcholine acylhydrolase , ec 3.1.1.8 ) , we utilized the physical parameter of thermolability . | NA | {
"id": "C0001044",
"name": "acetylcholine acetylhydrolase",
"pos": [
34,
63
]
} | {
"id": "C0008429",
"name": "acylcholine acylhydrolase",
"pos": [
107,
132
]
} |
when heated after isolation on density gradients , most of the forms of acetylcholinesterase and butyrylcholinesterase lost activity as a single exponential function of time . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
72,
92
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
97,
118
]
} |
the nmr titration curves of proton chemical shifts were observed for the c2 protons of histidine residues in intact bovine pancreatic rnaase a ( ec 3.1.27.5 ) and carboxyalkylated rnaase a . | NA | {
"id": "C0035541",
"name": "pancreatic rnaase",
"pos": [
123,
140
]
} | {
"id": "C0014241",
"name": "rnaase",
"pos": [
180,
186
]
} |
the microscopic structure estimated in the present study was discussed , comparing it with those from x-ray crystallography and hydrogen-tritium ( or hydrogen-deuterium ) exchange technique . | NA | {
"id": "C0041119",
"name": "tritium",
"pos": [
137,
144
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
150,
158
]
} |
the microscopic structure estimated in the present study was discussed , comparing it with those from x-ray crystallography and hydrogen-tritium ( or hydrogen-deuterium ) exchange technique . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
128,
136
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
159,
168
]
} |
amino acid analysis of the purified glycoprotein revealed an excess of acidic over basic amino acids and a relatively high content of nonpolar residues . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
83,
100
]
} |
gsh could not be replaced in prolonging the lag by cysteine , mercaptoethanol , dithiothreitol , propylthiouracil , or gssg . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
0,
3
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
119,
123
]
} |
a cationic amino acid copolymer ( cp530 ) with a molar ratio of lysine , leucine , tryptophan and phenylalanine of 11:2:1:1 and a mr of about 2300 was prepared and its inhibitory effects on the complement cascade was compared with those of polylysine with a mr of about 3000 . | NA | {
"id": "C0024337",
"name": "lysine",
"pos": [
64,
70
]
} | {
"id": "C0032518",
"name": "polylysine",
"pos": [
240,
250
]
} |
the release of prostaglandin e ( pge ) and prostaglandin f ( pgf ) into the medium , and their concentration in the zygotes after incubation , increased sharply on days 6 and 7 of pregnancy , reaching , by day 7 , values close to 200 ng of each pg released in 1 h per mg of protein . | NA | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
15,
30
]
} | {
"id": "C0033554",
"name": "pg",
"pos": [
245,
247
]
} |
the release of prostaglandin e ( pge ) and prostaglandin f ( pgf ) into the medium , and their concentration in the zygotes after incubation , increased sharply on days 6 and 7 of pregnancy , reaching , by day 7 , values close to 200 ng of each pg released in 1 h per mg of protein . | NA | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
43,
58
]
} | {
"id": "C0033554",
"name": "pg",
"pos": [
245,
247
]
} |
the systems that have been analyzed include monomolecular films , bilayer membranes , small discoidal lipid-protein complexes and plasma lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
102,
107
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
137,
149
]
} |
intranasal cocaine was administered as 100 mg powder consisting of an appropriate dose of cocaine hydrochloride ( 64 and 96 mg ) mixed with lactose powder . | NA | {
"id": "C0009170",
"name": "cocaine",
"pos": [
11,
18
]
} | {
"id": "C0282108",
"name": "cocaine hydrochloride",
"pos": [
90,
111
]
} |
however , both mitogenic and polyclonal response to lipopolysaccharide is not affected by cap and tap but severely inhibited by diu . | NA | {
"id": "C0008168",
"name": "cap",
"pos": [
90,
93
]
} | {
"id": "C0039854",
"name": "tap",
"pos": [
98,
101
]
} |
these differences suggest that the target mechanism of cap and tap differs from that of diu . | NA | {
"id": "C0008168",
"name": "cap",
"pos": [
55,
58
]
} | {
"id": "C0039854",
"name": "tap",
"pos": [
63,
66
]
} |
although it has been assumed that the microfibrils in hard -keratin are members of the class of structures known as intermediate filaments ( if ) , no firm chemical evidence relating the low-sulfur proteins in hard -keratin to other if proteins has yet been published . | NA | {
"id": "C0010803",
"name": "keratin",
"pos": [
60,
67
]
} | {
"id": "C0021769",
"name": "if",
"pos": [
233,
235
]
} |
we now present primary sequence data for two components from wool keratin which show striking similarities with two if proteins , desmin and vimentin . | NA | {
"id": "C0010803",
"name": "keratin",
"pos": [
66,
73
]
} | {
"id": "C0021769",
"name": "if",
"pos": [
116,
118
]
} |
we now present primary sequence data for two components from wool keratin which show striking similarities with two if proteins , desmin and vimentin . | NA | {
"id": "C0021769",
"name": "if",
"pos": [
116,
118
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
141,
149
]
} |
these data thus provide the first evidence that the low-sulfur proteins in hard -keratin and the other if proteins do indeed have both a similar structure and a common evolutionary origin . | NA | {
"id": "C0010803",
"name": "keratin",
"pos": [
81,
88
]
} | {
"id": "C0021769",
"name": "if proteins",
"pos": [
103,
114
]
} |
the best inhibitor is the 3-carboxylic acid ( ki congruent to 10 ( -4 ) m ) , while the ester , amide , and/or peptide derivatives are less potent . | NA | {
"id": "C0007066",
"name": "carboxylic acid",
"pos": [
28,
43
]
} | {
"id": "C0014898",
"name": "ester",
"pos": [
88,
93
]
} |
ascitic fluids were obtained and characterized with respect to their binding interaction with human factor v and factor va . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
100,
108
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
113,
122
]
} |
three hybridoma cell lines produce monoclonal antibodies that react equally well with factor v and factor va . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
86,
94
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
99,
108
]
} |
another antibody reacts with both antigens , but the reactivity with factor v is better than with factor va . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
69,
77
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
98,
107
]
} |
an additional two antibodies react with factor va better than factor v in the radioimmunoassay ( ria ) . | NA | {
"id": "C0015501",
"name": "factor va",
"pos": [
40,
49
]
} | {
"id": "C0015498",
"name": "factor v",
"pos": [
62,
70
]
} |
this antibody binds both factor v and factor va , releases them at high ionic strength , and has an apparent dissociation constant for factor va of 3 x 10 ( -9 ) m . | NA | {
"id": "C0015498",
"name": "factor",
"pos": [
25,
31
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
135,
144
]
} |
when human factor v ( mol wt 330,000 ) is activated by thrombin and passed over an alpha hfv-1-sepharose affinity resin , factor va binds and subsequently can be eluted . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
11,
19
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
122,
131
]
} |
experiments with direct immuno-precipitation of 125i-labeled antigens suggested that all four proteins investigated ( human platelet factor 4 , porcine platelet factor 4 , human low affinity platelet factor 4 or human beta-thromboglobulin , and porcine platelet basic protein ) share common antigenic determinants . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
61,
69
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
291,
313
]
} |
compared to nonvascular cells ( fibroblasts , corneal endothelial cells , fetal lung or intestinal mucosal cells ) , vascular cells had little procoagulant activity . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
32,
43
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
126,
131
]
} |
the activity in hpcm responsible for these changes cochromatographed on ultrogel aca44 columns with csf and with the less hydrophobic variant of csf ( csf-alpha ) on phenyl sepharose . | NA | {
"id": "C0009392",
"name": "csf",
"pos": [
100,
103
]
} | {
"id": "C0021757",
"name": "csf-alpha",
"pos": [
151,
160
]
} |
both csf-alpha and mouse spleen conditioned medium also contain eosinophil colony-stimulating activity ( csa ) , whereas inactive csfs with no effect on mature eosinophils , csf-beta , and mouse lung conditioned medium also lack eosinophil csa . | NA | {
"id": "C0021757",
"name": "csf-alpha",
"pos": [
5,
14
]
} | {
"id": "C0009392",
"name": "csf",
"pos": [
174,
177
]
} |
the average amount of hbf/f cell was less in cfu-e-derived f cells than in bfu-e-derived cells ( 3.5 +/- 0.3 pg versus 6.2 +/- 3.3 pg ; p less than 0.01 ) , while adult hemoglobin ( hba ) levels in cfu-e-and bfu-e-derived cells remained comparable ( 19.9 +/- 2.2 pg versus 21.9 +/- 5.3 pg , p = 0.3 ) . | NA | {
"id": "C0015936",
"name": "hbf",
"pos": [
22,
25
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
169,
179
]
} |
the average amount of hbf/f cell was less in cfu-e-derived f cells than in bfu-e-derived cells ( 3.5 +/- 0.3 pg versus 6.2 +/- 3.3 pg ; p less than 0.01 ) , while adult hemoglobin ( hba ) levels in cfu-e-and bfu-e-derived cells remained comparable ( 19.9 +/- 2.2 pg versus 21.9 +/- 5.3 pg , p = 0.3 ) . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
169,
179
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
182,
185
]
} |
using a dna fragment that maps greater than 40 kilobases ( kb ) 5 ' to the epsilon-gene as a probe , reduced amounts of normal fragments were found in the dna of affected family members . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
6,
11
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
155,
158
]
} |
alpha 1-acid glycoprotein ( orosomucoid ) , which belongs to the acute phase reactant 's proteins , and prealbumin , a highly sensitive nutritional protein , are two compounds whose blood levels vary in inverse proportion during perceptible-stage cancers : alpha 1-acid glycoprotein concentrations increase while prealbu... | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
65,
76
]
} | {
"id": "C0029297",
"name": "alpha 1-acid glycoprotein",
"pos": [
257,
282
]
} |
1 the effects of gamma-aminobutyric acid ( gaba ) and related substances were examined in guinea-pig ileum longitudinal muscle.2 gaba at doses ranging from 10 ( -7 ) m to 3 x 10 ( -6 ) m elicited a relaxation while at higher doses ( 3 x 10 ( -6 ) m - 10 ( -4 ) m ) , as previously described , it caused a contraction fol... | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
43,
47
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
419,
427
]
} |
a specific cross-desensitization occurred between gaba and ( - ) -baclofen.4 the bicuculline-insensitive relaxation induced by gaba and ( - ) -baclofen was prevented by tetrodotoxin and hyoscine but not by phentolamine plus propranolol , naloxone or theophylline.5 in preparations in which the muscle tone was raised by ... | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
50,
54
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
378,
386
]
} |
we confirm that gaba , homotaurine and muscimol are gaba ( a ) agonists , while gaba and ( - ) -baclofen are gaba ( b ) agonists . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
96,
104
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
109,
113
]
} |
3 phenobarbitone ( 80 mg kg-1 daily for 5 days ) produced a fall in dna content per unit mass of liver but no change in hepatic dna relative to body weight . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
8,
9
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
128,
131
]
} |
5 it is concluded that phenobarbitone increases liver size by hepatocyte enlargement rather than cellular proliferation but that the hepatomegaly produced by the hypolipidaemic agents , at least at some doses , is due to a mixture of both processes . | NA | {
"id": "C0020564",
"name": "enlargement",
"pos": [
73,
84
]
} | {
"id": "C0019209",
"name": "hepatomegaly",
"pos": [
133,
145
]
} |
3 the preferential alpha 2-adrenoceptor antagonist , yohimbine ( 0.1 microm ) significantly antagonized the inhibitory effect of clonidine or adrenaline on [ 3h ] -noradrenaline overflow elicited by electrical stimulation . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
142,
152
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
164,
177
]
} |
data from samples assayed for their adrenaline and noradrenaline content using a radioenzymatic technique were used to confirm or refute the suspected diagnosis . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
36,
46
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
51,
64
]
} |
overweight was defined as weight that exceeded the standard weight for height , age , and sex by more than 20 % ( relative weight greater than 120 % ) . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
0,
10
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
123,
129
]
} |
regardless of the quantity of morphine sulfate ( 1-500 ng ) given to the animals , the concentrations of norepinephrine and epinephrine in hypophysial portal plasma and femoral arterial plasma remained unchanged . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
105,
119
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
124,
135
]
} |
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