text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
no effect of morphine was observed on dopa accumulation in the median eminence of nsd-treated rats that had received 50 ng of morphine sulfate intracerebroventricularly , and only a 50 % reduction was observed in the accumulation of dopa in the median eminence of rats given 500 ng of morphine sulfate . | NA | {
"id": "C0026549",
"name": "morphine",
"pos": [
13,
21
]
} | {
"id": "C0066814",
"name": "morphine sulfate",
"pos": [
285,
301
]
} |
mammalian brain contains 3 peptides related to the pro-somatostatin molecule : somatostatin-14 ( ss14 ) , the form originally identified from hypothalamic extracts , somatostatin-28 ( ss28 ) and somatostatin 28 ( 1-12 ) ( ss28 ( 1-12 ) ) . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
79,
94
]
} | {
"id": "C0074854",
"name": "ss28",
"pos": [
222,
226
]
} |
these somatostatin-related peptides have a specific laminar distribution in cortex and are differentially distributed such that ss28 is largely restricted to cell bodies , whereas ss28 ( 1-12 ) is preferentially localized in neuronal processes and terminals in a density which far exceeds that revealed by ss-14 immunore... | NA | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
6,
18
]
} | {
"id": "C0074854",
"name": "ss28",
"pos": [
180,
184
]
} |
in addition , the enriched distribution of nerve fibers containing the antigenic determinant , ss28 ( 1-12 ) , strongly implies that somatostatin-related peptides constitute a major neurotransmitter system in neocortex . | NA | {
"id": "C0074854",
"name": "ss28",
"pos": [
95,
99
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
133,
145
]
} |
only lesions in the vmt-a10 area decreased the dopamine ( da ) content , which strongly suggests that the projection from this region to the lc is of dopaminergic nature . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
47,
55
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
150,
162
]
} |
however , cultures in which higher concentrations ( 10 ( -7 ) to 10 ( -5 ) m ) were maintained for the same period did not show complete recovery in terms of numbers of osteoclasts and number of nuclei per cell after withdrawal of hc , suggesting that precursor cells of osteoclasts were also damaged by hc . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
206,
210
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
252,
267
]
} |
a variety of bisphosphonates with aliphatic side chains of increasing length , as well as 3-amino-1-hydroxypropylidene-1,1-bisphosphonate ( ahprbp , formerly apd ) , dichloromethylene-bisphosphonate ( cl2mbp , formerly cl2mdp ) , and dibromomethylene bisphosphonate ( br2mbp , formerly br2mdp ) , were compared in vitro ... | NA | {
"id": "C0012544",
"name": "bisphosphonates",
"pos": [
13,
28
]
} | {
"id": "C0012081",
"name": "cl2mdp",
"pos": [
219,
225
]
} |
previous studies have suggested that the release of dopamine ( da ) in the rat brain may be sensitive to modulation by opioid agents , including the endogenous opioid peptides ( enkephalins and endorphins ) . | NA | {
"id": "C0205753",
"name": "endogenous",
"pos": [
149,
159
]
} | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
178,
189
]
} |
previous studies have suggested that the release of dopamine ( da ) in the rat brain may be sensitive to modulation by opioid agents , including the endogenous opioid peptides ( enkephalins and endorphins ) . | NA | {
"id": "C0205753",
"name": "endogenous",
"pos": [
149,
159
]
} | {
"id": "C0014242",
"name": "endorphins",
"pos": [
194,
204
]
} |
these receptor studies have led , for example , to ( a ) the identification of 17-alpha estrogens that interact with the opiate receptor , ( b ) the delineation of a unique class of opiate receptor that mediates explosive motor behavior and is resistant to naloxone , ( c ) the discovery of progesterone derivatives and ... | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
838,
855
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
866,
874
]
} |
the prostaglandins , prostacyclins , thromboxanes , and leukotrienes will continue to receive attention in the near future , and the role of diet in modulating the concentrations of these compounds in blood and other body tissues is a promising area of active research . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
4,
18
]
} | {
"id": "C0205911",
"name": "prostacyclins",
"pos": [
21,
34
]
} |
serum levels of four acute phase proteins , alpha 1-acid glycoprotein ( aagp ) , alpha 1-antitrypsin ( aat ) , haptoglobin ( hpt ) , and c3 , were measured prior to biopsy in 38 women subsequently shown to have stage i and ii breast cancer and prior to treatment in 16 women with stage iv disease . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
21,
41
]
} | {
"id": "C0029297",
"name": "alpha 1-acid glycoprotein",
"pos": [
44,
69
]
} |
serum levels of four acute phase proteins , alpha 1-acid glycoprotein ( aagp ) , alpha 1-antitrypsin ( aat ) , haptoglobin ( hpt ) , and c3 , were measured prior to biopsy in 38 women subsequently shown to have stage i and ii breast cancer and prior to treatment in 16 women with stage iv disease . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
21,
41
]
} | {
"id": "C0002191",
"name": "alpha 1-antitrypsin",
"pos": [
81,
100
]
} |
serum levels of four acute phase proteins , alpha 1-acid glycoprotein ( aagp ) , alpha 1-antitrypsin ( aat ) , haptoglobin ( hpt ) , and c3 , were measured prior to biopsy in 38 women subsequently shown to have stage i and ii breast cancer and prior to treatment in 16 women with stage iv disease . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
21,
41
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
111,
122
]
} |
philadelphia chromosome-positive cells with a standard translocation ( 9 ; 22 ) were found in bone marrow and peripheral blood samples from a patient with non-hodgkin 's lymphoma ( immunoblastic sarcoma ) in the final leukemic phase . | NA | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
155,
178
]
} | {
"id": "C0079746",
"name": "immunoblastic sarcoma",
"pos": [
181,
202
]
} |
mouse monoclonal antibodies alpha pro3 and alpha pro5 bind to different epitopes on an antigen ( p54 ) of 54 kd reduced and 175 kd nonreduced mw . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
72,
80
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
87,
94
]
} |
fructanase of s. mutans readily hydrolysed ( 2 leads to 6 ) -beta-d-fructans , but ( 2 leads to 1 ) -beta-d-fructans and inulin were more resistant . | NA | {
"id": "C0016743",
"name": "fructans",
"pos": [
68,
76
]
} | {
"id": "C0021936",
"name": "inulin",
"pos": [
121,
127
]
} |
recent developments may have pointed the way to a future understanding of the chemistry of lipid-protein interactions , the clearance of atherogenic particles , the metabolic interactions between lipoproteins , and the regulation of lipid modifying enzymes . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
196,
208
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
233,
238
]
} |
antibodies were purified from an antiserum that reacted with both lectin i and lectin ii and from the same antiserum rendered monospecific for lectin i . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
107,
116
]
} |
the 4026 nucleotide long fbj-musv proviral dna contains two long terminal repeats , a substitution of 1639 nucleotides of mouse cellular dna ( v-fos ) and the 3 ' end of the env gene derived from fbj-mulv . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
43,
46
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
151,
152
]
} |
these secondary structures are formed in growing plasmodia , as seen in electron micrographs of native rdna molecules , which also reveal apparent recombination forms involving rdna ends and noncontiguous dna segments . | NA | {
"id": "C0012933",
"name": "rdna",
"pos": [
103,
107
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
205,
208
]
} |
systemic administration of the prostaglandin ( 15s ) -15-methyl pge-1 reduced splenomegaly approximately 50 % in f1 mice which were injected with c57bl/6 or cba cells . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
31,
44
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
64,
67
]
} |
to investigate mechanisms by which antigen , macrophages , and interleukin 2 ( il2 ) participate in the induction of secondary t-cell proliferative responses , trinitrophenyl ( tnp ) was presented in three distinct modes : ( i ) tnp-modified peripheral blood mononuclear cells ( tnp-pbmc ) , ( ii ) tnp-pbmc cell sonicat... | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
283,
287
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
308,
312
]
} |
whereas mononuclear cells from all blood donors tested were proliferative to okt3 , cells from 12 of 30 donors ( 40 % ) were unresponsive to anti-leu 4 . | NA | {
"id": "C1321301",
"name": "mononuclear",
"pos": [
8,
19
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
84,
89
]
} |
with this procedure , carbohydrate-rich proteins can be detected with negligible background staining and insignificant staining of nonglycoproteins such as albumin and nonglycosylated bence jones proteins ( free light chains ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
40,
48
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
156,
163
]
} |
the assay systems consisted of polystyrene balls with immobilized antibody f ( ab ' ) 2 fragments and antibody fab ' fragments labeled with beta-d-galactosidase from e. coli . | NA | {
"id": "C0021009",
"name": "antibody",
"pos": [
66,
74
]
} | {
"id": "C0021031",
"name": "antibody fab",
"pos": [
102,
114
]
} |
a reliable high-performance liquid chromatographic method is presented for the determination of the urinary free catecholamines noradrenaline , adrenaline and dopamine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
128,
141
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
144,
154
]
} |
it allows the determination of urinary free catecholamines in concentrations as low as 1 microgram/1 for noradrenaline and adrenaline and 5 micrograms/1 for dopamine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
105,
118
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
123,
133
]
} |
the within-assay and between-assay coefficients of variation of the analyses in urine were both 2.9 % for noradrenaline , both 5.0 % for adrenaline , and 1.9 and 2.1 % for dopamine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
106,
119
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
137,
147
]
} |
the major lysosomal hydrolase activities in normal epithelial cells are lower than those in normal fibroblasts . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
99,
110
]
} |
one human urinary ribonuclease ( rnase ul ) showed strong immunological identity with human pancreatic ribonuclease , and the other ribonuclease ( rnase us ) showed strong immuno cross-reactivity with human liver ribonuclease . | NA | {
"id": "C0035541",
"name": "pancreatic",
"pos": [
92,
102
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
147,
152
]
} |
these cases suggest an association between the lipoid nephrosis-focal segmental glomerulosclerosis group of glomerular diseases and crescentic glomerulonephritis , and may represent an unusual pathway in the evolution of childhood nephrosis . | NA | {
"id": "C0027721",
"name": "lipoid nephrosis",
"pos": [
47,
63
]
} | {
"id": "C0027720",
"name": "nephrosis",
"pos": [
231,
240
]
} |
tizolemide , a new sulphonamide diuretic , has alkaline properties and is cleared by a tubular transport system which differs from the pah-excreting system which transports thiazide diuretics . | NA | {
"id": "C0012798",
"name": "diuretic",
"pos": [
32,
40
]
} | {
"id": "C0012802",
"name": "thiazide diuretics",
"pos": [
173,
191
]
} |
thus , sss is frequently associated with a significant attenuation of sinus arrhythmia and the simple measurement of delta r-rmax in standard ecg recordings provides useful diagnostic information . | NA | {
"id": "C0037052",
"name": "sss",
"pos": [
7,
10
]
} | {
"id": "C0003813",
"name": "sinus arrhythmia",
"pos": [
70,
86
]
} |
pretreatment with ethanol and supplementation to keep blood ethanol concentration above 800 mg/l for 8 hr also did not alter ptu disposition . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
18,
25
]
} | {
"id": "C0684262",
"name": "blood ethanol concentration",
"pos": [
54,
81
]
} |
these data indicate that young children eliminate bleomycin more rapidly than older children and that children with impaired renal function may have prolonged elevations in plasma concentration due to reduced bleomycin clearance . | NA | {
"id": "C0728836",
"name": "young",
"pos": [
25,
30
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
102,
110
]
} |
these data indicate that young children eliminate bleomycin more rapidly than older children and that children with impaired renal function may have prolonged elevations in plasma concentration due to reduced bleomycin clearance . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
78,
92
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
102,
110
]
} |
17.3 % were referred because of trauma , with a total fracture incidence of 4.1 % as compared with 9.5 % in the other age-sex groups . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
32,
38
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
54,
62
]
} |
prolyl hydroxylase activity in normal fibroblasts grown to confluency in 1.5 microm hydrocortisone was approximately half that of cells grown without the steroid . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
38,
49
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
130,
135
]
} |
the purpose of this study was to find out the effects of the oral hygiene on the condition of the periodontal tissues and the frequency of gingivitis and periodontal disease and their severity in this age group . | NA | {
"id": "C0031090",
"name": "condition",
"pos": [
81,
90
]
} | {
"id": "C0017563",
"name": "periodontal disease",
"pos": [
154,
173
]
} |
the purpose of this study was to find out the effects of the oral hygiene on the condition of the periodontal tissues and the frequency of gingivitis and periodontal disease and their severity in this age group . | NA | {
"id": "C0017574",
"name": "gingivitis",
"pos": [
139,
149
]
} | {
"id": "C0017563",
"name": "periodontal disease",
"pos": [
154,
173
]
} |
gingivitis was discovered in 60.6 % , and periodontal disease ( with periodontal pockets ) in 34.1 % of the examined pupils . | NA | {
"id": "C0017574",
"name": "gingivitis",
"pos": [
0,
10
]
} | {
"id": "C0017563",
"name": "periodontal disease",
"pos": [
42,
61
]
} |
water-balance computations indicate that this species should be able to maintain water balance at 25 degrees c on a high-protein diet with a water content of about 60 % without access to drinking water ; | NA | {
"id": "C0043047",
"name": "water",
"pos": [
0,
5
]
} | {
"id": "C0599638",
"name": "drinking",
"pos": [
187,
195
]
} |
the level of 25-hydroxyvitamin d3 [ 25 ( oh ) d3 ] , the main circulating form of vitamin d , was low in d- dams and was not detected in d- weanlings . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
13,
33
]
} | {
"id": "C2713074",
"name": "25 ( oh ) d3",
"pos": [
36,
48
]
} |
of 10 amino acids tested , only 14c-labelled asparate and , to a lesser extent alanine , generated substantial amounts of 14co2 when incubated with h. diminuta . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
6,
17
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
79,
86
]
} |
although it is possible that this enzyme is an isozyme of the true ache of excitable membranes , or that it is an incomplete enzyme fragment , it is also possible that there is a unique membrane-bound ache present in large quantities in crustacean peripheral nerve . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
47,
54
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
125,
131
]
} |
the quantitative estimation of total acetylcholine content in the whole brain tissue in normal egyptian gerbil gerbillus pyramidum , gives an average of 1.43 +/- 0.06 micrograms of acetylcholine chloride/g fresh brain tissue . | NA | {
"id": "C0001041",
"name": "acetylcholine",
"pos": [
37,
50
]
} | {
"id": "C0055389",
"name": "acetylcholine chloride",
"pos": [
181,
203
]
} |
the concentration of epinephrine , norepinephrine and dopamine , and the activity of norepinephrine n-methyltransferase , the epinephrine-forming enzyme , were determined in hypothalamus and brain stem in several species . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
35,
49
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
126,
137
]
} |
seventy women with prolactinomas , age 19-38 years , were studied in order to evaluate a possible relationship between the use of steroidal oral contraceptives ( o.c . ) and the development of prolactin-producing adenomas . | NA | {
"id": "C0033375",
"name": "prolactinomas",
"pos": [
19,
32
]
} | {
"id": "C0001430",
"name": "adenomas",
"pos": [
213,
221
]
} |
we further demonstrated the increased pulmonary microvascular permeability of noncardiac pulmonary edema compared with cardiac edema by the greater evlw at normal microvascular hydrostatic pressures in the former group . | NA | {
"id": "C0013604",
"name": "edema",
"pos": [
99,
104
]
} | {
"id": "C0013608",
"name": "cardiac edema",
"pos": [
119,
132
]
} |
in addition to other elements , levels of thorium ( th ) , which is generally present as an impurity of re compounds , were also determined to estimate the radiation dose which may be involved in inducing pneumoconiosis . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
21,
29
]
} | {
"id": "C0025556",
"name": "re",
"pos": [
121,
123
]
} |
although atp levels were preserved at the end of hca in all groups , adenosine infusion with or without ehna prevented the significant 23 percent decline in atp stores incurred during unmodified reperfusion ( p less than 0.01 , group 1 ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
69,
78
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
157,
160
]
} |
the drugs were the classical nystatin and amphotericin-b , 5-flucytosine , and 5 imidazoles , clotrimazole , econazole , ketoconazole , miconazole , and tioconazole . | NA | {
"id": "C0020924",
"name": "imidazoles",
"pos": [
81,
91
]
} | {
"id": "C0009074",
"name": "clotrimazole",
"pos": [
94,
106
]
} |
the drugs were the classical nystatin and amphotericin-b , 5-flucytosine , and 5 imidazoles , clotrimazole , econazole , ketoconazole , miconazole , and tioconazole . | NA | {
"id": "C0020924",
"name": "imidazoles",
"pos": [
81,
91
]
} | {
"id": "C0013547",
"name": "econazole",
"pos": [
109,
118
]
} |
the drugs were the classical nystatin and amphotericin-b , 5-flucytosine , and 5 imidazoles , clotrimazole , econazole , ketoconazole , miconazole , and tioconazole . | NA | {
"id": "C0020924",
"name": "imidazoles",
"pos": [
81,
91
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
136,
146
]
} |
the effects of subminimal inhibitory concentrations of kanamycin , amikacin and gentamicin on the production of penicillinase by staphylococcus aureus were tested on 12 penicillin-resistant strains . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
55,
64
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
67,
75
]
} |
in vitro antibacterial activity of cefmenoxime was superior to 18 other antibiotics , including cefotiam and cefotaxime tested in this study . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
35,
46
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
109,
119
]
} |
in vitro antibacterial activity of cefmenoxime was superior to 18 other antibiotics , including cefotiam and cefotaxime tested in this study . | NA | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
96,
104
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
109,
119
]
} |
pharmacokinetic studies on tissue distribution in rats , serum levels and urinary excretion in 3 healthy volunteers , and penetration into bronchial secretes of 9 patients with respiratory infections , revealed that cefmenoxime has a higher penetration into the lung and bronchial secretes compared with cefotiam and cef... | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
216,
227
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
317,
327
]
} |
pharmacokinetic studies on tissue distribution in rats , serum levels and urinary excretion in 3 healthy volunteers , and penetration into bronchial secretes of 9 patients with respiratory infections , revealed that cefmenoxime has a higher penetration into the lung and bronchial secretes compared with cefotiam and cef... | NA | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
304,
312
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
317,
327
]
} |
from these results , it is concluded that cefmenoxime is a highly potent and useful antibiotic , and may be more effective in the treatment of respiratory infections than many other cephalosporins , including cefazolin , cefotiam and cefotaxime . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
42,
53
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
234,
244
]
} |
from these results , it is concluded that cefmenoxime is a highly potent and useful antibiotic , and may be more effective in the treatment of respiratory infections than many other cephalosporins , including cefazolin , cefotiam and cefotaxime . | NA | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
221,
229
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
234,
244
]
} |
epidural hematomas of the posterior fossa in children have a tendency to liquefy earlier than supratentorial hematomas . | NA | {
"id": "C0238154",
"name": "epidural",
"pos": [
0,
8
]
} | {
"id": "C0018944",
"name": "hematomas",
"pos": [
109,
118
]
} |
both macro- and microscopically , such tumors resembled in most cases the well-known cerebellar astrocytoma , presenting as a large cyst with a mural nodule with the pattern of a pilocytic astrocytoma ( i.e . spongioblastoma of the german school ) . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
39,
45
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
132,
136
]
} |
the increase in urinary output of calcium after solid calcium carbonate was greater in the subjects with the most gastric secretion of acid . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
34,
41
]
} | {
"id": "C0006681",
"name": "calcium carbonate",
"pos": [
54,
71
]
} |
in the four subjects with the least gastric secretion of acid , there was no absorption of calcium after calcium carbonate , but the absorption after monocalcium citrate was as great as that for those who secreted greater amounts of acid . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
91,
98
]
} | {
"id": "C0006681",
"name": "calcium carbonate",
"pos": [
105,
122
]
} |
ketoconazole , an orally active imidazole derivative , has been approved by the food and drug administration for the treatment of candidiasis , chronic mucocutaneous candidiasis , oral thrush , candiduria , coccidioidomycosis , histoplasmosis , chromomycosis , and paracoccidioidomycosis . | NA | {
"id": "C0006840",
"name": "candidiasis",
"pos": [
130,
141
]
} | {
"id": "C0006845",
"name": "chronic mucocutaneous candidiasis",
"pos": [
144,
177
]
} |
mucous tubules produce a carbohydrate-rich secretion containing glycoconjugate with terminal sialic acids , penultimate galactose residues , and a variable degree of sulfation like the glycoconjugate of surface mucous cells . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
25,
37
]
} | {
"id": "C0017906",
"name": "glycoconjugate",
"pos": [
185,
199
]
} |
as expected , the relative levels of aminoacyl-trna synthetases , protein chain elongation factors , ribosomal proteins , and the alpha-subunit of rna polymerase are all increased with increased growth rate ; | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
66,
73
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
101,
119
]
} |
the polypeptide patterns revealed a six-times-higher ratio of the apoprotein ( 1 ) of p700 chlorophyll a protein to the apoprotein ( 2 ) of one of the chlorophyll a proteins in photosystem ii in the light ( stroma ) fraction as compared with the heavy ( grana ) fraction indicating different distribution of the two phot... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
69,
76
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
120,
130
]
} |
binding of a fluorescent allosteric effector , beta-naphthyl triphosphate ( beta-napp3 ) , to human adult hemoglobin ( hba ) at various levels of oxygen saturation were investigated by simultaneous measurements of fluorescence , absorbance and oxygen partial pressure . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
106,
116
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
119,
122
]
} |
phosphorylase b ' , a modified form of phosphorylase in which the phosphorylation site has been removed by limited tryptic attack , presented an activation profile similar to that of phosphorylase b . | NA | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
0,
13
]
} | {
"id": "C0031711",
"name": "phosphorylase",
"pos": [
183,
196
]
} |
in contrast , phosphorylase a was inhibited by the bile salt , while the activity of liver phosphorylase b was not significantly affected . | NA | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
14,
27
]
} | {
"id": "C0031711",
"name": "phosphorylase b",
"pos": [
91,
106
]
} |
hydrolysis of the lipopolysaccharide in 1 % acetic acid afforded o-polysaccharide ( 19 % by weight ) , core-oligosaccharide ( 12.2 % ) and lipid a ( 44.6 % ) . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
18,
36
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
139,
146
]
} |
hydrolysis of the lipopolysaccharide in 1 % acetic acid afforded o-polysaccharide ( 19 % by weight ) , core-oligosaccharide ( 12.2 % ) and lipid a ( 44.6 % ) . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
22,
36
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
108,
123
]
} |
the specific binding activity ranges from 1.18 pmol alpha-bungarotoxin bound/mg protein for the membrane-bound site up to a maximum of 230 pmol bound/mg protein for the partially purified component . | NA | {
"id": "C0025252",
"name": "protein",
"pos": [
80,
87
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
153,
160
]
} |
c3h/1ot1/2 clone 8 mouse fibroblasts ( c3h/1ot1/2 cells ) exhibit induction of aryl hydrocarbon hydroxylase ( cytochrome p1-450 ) when exposed in culture to benzo ( a ) pyrene , benz ( a ) anthracene or 2,3,7,8-tetrachlorodibenzo-p-dioxin ( tcdd ) , but do not display the induction response when treated with 3-methylch... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
25,
36
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
50,
55
]
} |
c3h/1ot1/2 clone 8 mouse fibroblasts ( c3h/1ot1/2 cells ) exhibit induction of aryl hydrocarbon hydroxylase ( cytochrome p1-450 ) when exposed in culture to benzo ( a ) pyrene , benz ( a ) anthracene or 2,3,7,8-tetrachlorodibenzo-p-dioxin ( tcdd ) , but do not display the induction response when treated with 3-methylch... | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
79,
107
]
} | {
"id": "C0059735",
"name": "cytochrome p1-450",
"pos": [
366,
383
]
} |
the three related peptides are , moreover , clearly homologous to the copper-binding areas in the small blue plant and bacterial proteins plastocyanin and azurin . | NA | {
"id": "C0004627",
"name": "bacterial proteins",
"pos": [
119,
137
]
} | {
"id": "C0004525",
"name": "azurin",
"pos": [
155,
161
]
} |
the results showed that the four protein phosphatases defined in the preceding paper , namely protein phosphatases-1 , 2a , 2b and 2c [ ingebritsen , t. s. and cohen , p. ( 1983 ) eur . j. biochem . 132 , 255-261 ] were the only significant enzymes acting on these substrates . | NA | {
"id": "C0031686",
"name": "protein",
"pos": [
33,
40
]
} | {
"id": "C1956003",
"name": "protein phosphatases-1",
"pos": [
94,
116
]
} |
protein phosphatase-2c was eluted from deae-cellulose at the leading edge of the peak of protein phosphatase-2a1 . | NA | {
"id": "C0247248",
"name": "protein",
"pos": [
0,
7
]
} | {
"id": "C0031686",
"name": "protein phosphatase",
"pos": [
89,
108
]
} |
two forms of protein phosphatase-1 can be identified by chromatography on deae-cellulose , namely protein phosphatase-1 itself and the mg x atp-dependent protein phosphatase . | NA | {
"id": "C1956003",
"name": "protein phosphatase-1",
"pos": [
13,
34
]
} | {
"id": "C0031686",
"name": "protein",
"pos": [
154,
161
]
} |
the results show that protein phosphatases-1 , 2a and 2c are the only significant protein phosphatases in rat liver acting on these four substrates . | NA | {
"id": "C1956003",
"name": "protein phosphatases-1",
"pos": [
22,
44
]
} | {
"id": "C0031686",
"name": "protein phosphatases",
"pos": [
82,
102
]
} |
classification of two homogeneous myosin light chain phosphatases from smooth muscle as protein phosphatase-2a1 and 2c , and a homogeneous protein phosphatase from reticulocytes active on protein synthesis initiation factor eif-2 as protein phosphatase-2a2 . | NA | {
"id": "C0067062",
"name": "myosin light chain phosphatases",
"pos": [
34,
65
]
} | {
"id": "C0031686",
"name": "protein phosphatase",
"pos": [
233,
252
]
} |
in skeletal muscle , protein phosphatase-1 was the major enzyme acting on phosphorylase , glycogen synthase and phosphorylase kinase ( beta-subunit ) , and thus was the major protein phosphatase responsible for the inactivation of glycogenolysis and stimulation of glycogen synthesis . | NA | {
"id": "C1956003",
"name": "protein",
"pos": [
21,
28
]
} | {
"id": "C0031686",
"name": "protein",
"pos": [
175,
182
]
} |
the spectra of the free lac operator dna are similar to those obtained from ring-current-shift calculations for a b-dna structure . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
37,
40
]
} | {
"id": "C0919262",
"name": "b-dna",
"pos": [
114,
119
]
} |
the molecular weights of the viral proteins were determined by comparison with proteins of known molecular weight and are comparable to several of the vaccinia-wr-specific dna-binding proteins isolated previously from infected l-929 cells by solosky j . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
29,
43
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
184,
192
]
} |
the molecular weights of the viral proteins were determined by comparison with proteins of known molecular weight and are comparable to several of the vaccinia-wr-specific dna-binding proteins isolated previously from infected l-929 cells by solosky j . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
35,
43
]
} | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
172,
192
]
} |
analysis of the rates of synthesis of other proteins coded for by the s12 operon revealed that protein s12 was moderately over-produced , but elongation factors ef-g and ef-tu appear to be synthesized at the same rate as ef-ts , all three being moderately under-synthesized relative to total soluble proteins . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
25,
34
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
300,
307
]
} |
in man , the marked decrease in left ventricular filling pressure and the variable increase in stroke volume induced by renin-angiotensin blockade suggests that angiotensin ii actively constricts venous as well as arteriolar vascular beds . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
126,
137
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
161,
175
]
} |
the nature of cardiac alpha-adrenoceptors is apparently distinct from that of other organs as they are stimulated by dopamine and adrenaline but not by the transmitter noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
130,
140
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
168,
181
]
} |
the specific binding sites for cardiac glycosides in the human heart have certain properties which make it likely that they are the pharmacological receptors for the therapeutic and toxic actions of digitalis glycosides : they are located in the cell membrane and bind cardioactive steroids reversibly with high affinity... | NA | {
"id": "C0012253",
"name": "digitalis glycosides",
"pos": [
199,
219
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
414,
421
]
} |
this muscle atrophy remained confined to the primary site for 13-18 years , being followed in 4 cases by a mild muscle atrophy of the right upper arm or or the left forearm and hand and in 1 case by atrophy of the legs and the facial muscles . | NA | {
"id": "C0026846",
"name": "muscle atrophy",
"pos": [
5,
19
]
} | {
"id": "C0333641",
"name": "atrophy",
"pos": [
199,
206
]
} |
pharmacokinetics of chlorambucil in man after administration of the free drug and its prednisolone ester ( prednimustine , leo 1031 ) . | NA | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
20,
32
]
} | {
"id": "C0032949",
"name": "prednimustine",
"pos": [
107,
120
]
} |
the pharmacokinetics of chlorambucil has been investigated in a cross over study after oral administration of the free drug ( 10 mg ) and its prednisolone ester ( prednimustine , 100 mg ) . | NA | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
24,
36
]
} | {
"id": "C0032949",
"name": "prednimustine",
"pos": [
163,
176
]
} |
the bioavailability of chlorambucil was about five times lower when given as prednimustine as compared to administration of the free drug . | NA | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
23,
35
]
} | {
"id": "C0032949",
"name": "prednimustine",
"pos": [
77,
90
]
} |
adult rats submitted to perinatal protein deprivation ( from day 14 of fetal life till 50 days of age ) followed by a longer phase of nutritional recovery on balanced laboratory chow , showed a significant decrease of the pressor response elicited by noradrenaline and adrenaline , an effect that persisted after ganglio... | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
251,
264
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
269,
279
]
} |
purified endotoxin of e. coli o111b4 also decreased the number of beta-adrenoceptors , while e. coli j5-lps did not . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
9,
18
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
104,
107
]
} |
intact endotoxin seems to be necessary since neither the isolated lipid nor the polysaccharide part of e. coli o111b4 lps affected the number of beta-adrenoceptors in the lung . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
7,
16
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
118,
121
]
} |
( + ) -butaclamol was a potent inhibitor of dopamine , n-methyldopamine and noradrenaline ( ki congruent to 30-60 nm ) , but was less effective on ergometrine ( ki congruent to 310 nm ) . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
44,
52
]
} | {
"id": "C0011498",
"name": "methyldopamine",
"pos": [
57,
71
]
} |
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