text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the depletion of cytosol receptors was dose-dependent for each glucocorticoid , with the following ed50 ( mg/kg ) : fluocinolone acetonide 0.032 , dexamethasone 0.09 , triamcinolone acetonide 0.12 , betamethasone 0.24 , deflazacort 0.55 , triamcinolone 1.6 , prednisolone 4.0 , hydrocortisone 17.0 . | NA | {
"id": "C0040866",
"name": "triamcinolone acetonide",
"pos": [
168,
191
]
} | {
"id": "C0040864",
"name": "triamcinolone",
"pos": [
239,
252
]
} |
noradrenaline and adrenaline ( via beta-receptors ) , adenosine , and prostacyclin all relaxed inner more than outer muscle in coronary arteries contracted by histamine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
0,
13
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
18,
28
]
} |
a 52 000 d polypeptide component of the core is tentatively identified as the intermediate filament protein vimentin . | NA | {
"id": "C0021769",
"name": "intermediate filament protein",
"pos": [
78,
107
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
108,
116
]
} |
autophagic vacuoles regressed rapidly after administration of 0.2 mg/g body weight cycloheximide to the animals and the decay appeared to follow first-order kinetics ( average half-life 5.8 min , rate constant of regression 0.120 min-1 ) . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
157,
165
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
176,
185
]
} |
southern blot analyses using a probe made from a recombinant dna clone containing the albumin gene revealed that the dna associated with the residual structure was not enriched ( or depleted ) in this gene sequence . | NA | {
"id": "C0012931",
"name": "recombinant dna",
"pos": [
49,
64
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
117,
120
]
} |
on an extracellular matrix , prepared from normal embryonic fibroblasts , metabolic cooperation between ci-4 and don cells was autoradiographically measured to be 68 % . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
60,
71
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
117,
122
]
} |
like migratory fibroblasts , and unlike colony-forming epithelial cells , these cells show a pronounced horizontal polarization , and develop a large lamella at their leading front . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
15,
26
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
80,
85
]
} |
the addition of lysosomal enzymes derived from normal human fibroblasts to 35so4-labeled i cells , however , resulted in the turnover of pericellular gags and this effect was inhibited by m6p . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
60,
71
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
91,
96
]
} |
in contrast normal human diploid fibroblasts ( hdf ) do not induce dna synthesis in either quiescent cells or senescent cells . | NA | {
"id": "C0016030",
"name": "hdf",
"pos": [
47,
50
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
120,
125
]
} |
precursor cell analysis , after sorting of bone marrow cells using a fluorescence-activated cell sorter , suggests that the antigen is absent from most progenitors with the exception of certain cells in the macrophage lineage . | NA | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
0,
14
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
194,
199
]
} |
in the dysplastic small-bowel mucosa adjacent to the tumour , the maturation disorder of the epithelial cells was similar to changes described in the precancerous states of the colon . | NA | {
"id": "C0027651",
"name": "tumour",
"pos": [
53,
59
]
} | {
"id": "C0032927",
"name": "precancerous states",
"pos": [
150,
169
]
} |
the sequence indicates that canp is a thiol protease and its comparison with other thiol proteases is described . | NA | {
"id": "C0006784",
"name": "canp",
"pos": [
28,
32
]
} | {
"id": "C0010661",
"name": "thiol proteases",
"pos": [
83,
98
]
} |
enrichment cultures inoculated with dental plaque obtained from macaca fascicularis produced methane when the medium contained ethanol , methanol , lactate , acetate or a hydrogen + co2 atmosphere . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
127,
134
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
137,
145
]
} |
cholesterol and saturated cholesteryl esters accumulated in cultured arterial smooth muscle cells ( smc ) infected with mdv . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
0,
11
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
26,
44
]
} |
studies of the interaction of pigeon lipoproteins with pigeon peritoneal macrophages and aortic smooth muscle cells have shown that macrophages may be particularly important in the pathogenesis of cholesterol-aggravated atherosclerosis , especially when abnormal lipo-proteins such as cholesteryl ester-rich beta-very lo... | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
197,
208
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
285,
302
]
} |
of the luteinizing hormone-releasing hormone ( lh-rh ) agonist ( d-ser [ tbu ] 6-des-gly-nh2 ( 10 ) ) lh-rh ethylamide ( buserelin ) were administered on days 1 to 10 after the midcycle luteinizing hormone ( lh ) surge in 33 normally cycling women . | NA | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
47,
52
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
121,
130
]
} |
single increasing intranasal and subcutaneous doses of a potent luteinizing hormone-releasing hormone ( lh-rh ) agonistic analog ( d-ser [ tbu ] 6-des-gly-nh2 ( 10 ) ) lh-rh ethylamide ( buserelin ) were administered on day 2 or 3 of the follicular phase in 59 normal women . | NA | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
104,
109
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
187,
196
]
} |
placental proteins ( human chorionic gonadotropin , human placental lactogen , pregnancy-specific beta 1-glycoprotein , and placental protein 5 ) in seminal plasma of normal men and patients with infertility . | NA | {
"id": "C0032974",
"name": "placental proteins",
"pos": [
0,
18
]
} | {
"id": "C0033002",
"name": "pregnancy-specific beta 1-glycoprotein",
"pos": [
79,
117
]
} |
placental proteins , including human chorionic gonadotropin ( hcg ) , human placental lactogen ( hpl ) , pregnancy-specific beta 1-glycoprotein ( sp1 ) , and placental protein 5 ( pp5 ) have been detected in human seminal plasma of 20 normal men and 42 patients with infertility . | NA | {
"id": "C0032974",
"name": "placental proteins",
"pos": [
0,
18
]
} | {
"id": "C0033002",
"name": "pregnancy-specific beta 1-glycoprotein",
"pos": [
105,
143
]
} |
[ effect of hormones on adrenaline and noradrenaline release in the inferior mesenteric ganglion in the dog ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
24,
34
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
39,
52
]
} |
it was further observed that : 1 ) low concentrations of anti-afp igg appeared responsible for fetal death in early pregnancy and , 2 ) that antibodies , which did not readily bind to an affinity column , may possibly have caused fetal resorption . | NA | {
"id": "C0015927",
"name": "fetal death",
"pos": [
95,
106
]
} | {
"id": "C0015951",
"name": "fetal resorption",
"pos": [
230,
246
]
} |
the described experiments examined the role of cellular and extracellular atp on hsf and hgf attachment . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
47,
55
]
} | {
"id": "C0016030",
"name": "hgf",
"pos": [
89,
92
]
} |
these two types of fibroblasts differed in their cellular atp levels and their response to metabolic inhibitors . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
19,
30
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
49,
57
]
} |
as compared to insulin , dose-response curves obtained with proinsulin on these parameters show at least a 10-fold decrease in sensitivity of the cells . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
15,
22
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
60,
70
]
} |
in contrast , the growth-promoting effects of both insulin and proinsulin occur at supraphysiological concentrations ( ec50 greater than 300 nm ) . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
51,
58
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
63,
73
]
} |
17-hydroxylase activity was determined by assaying the metabolism of [ 3h ] pregnenolone to [ 3h ] 17-hydroxypregnenolone by high performance liquid chromatography ( hplc ) . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
76,
88
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
99,
121
]
} |
conversion of [ 3h ] pregnenolone to [ 3h ] progesterone and [ 3h ] 17-hydroxypregnenolone to [ 3h ] 17-hydroxyprogesterone was prevented by the addition of cyanoketone , an inhibitor of 3 beta-hydroxysteroid dehydrogenase . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
21,
33
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
68,
90
]
} |
conversion of [ 3h ] pregnenolone to [ 3h ] progesterone and [ 3h ] 17-hydroxypregnenolone to [ 3h ] 17-hydroxyprogesterone was prevented by the addition of cyanoketone , an inhibitor of 3 beta-hydroxysteroid dehydrogenase . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
44,
56
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
101,
123
]
} |
antibodies that bind to both synaptic and extrasynaptic muscle fiber bl , in vivo stain the entire myotube bl in vitro , while antisera that bind preferentially to synaptic bl in vivo stain small patches of myotube bl , which are usually associated with regions rich in acetylcholine receptors . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
127,
135
]
} |
in order to bolster the argument that parallel developmental changes in erythrocyte adult hemoglobin ( hba ) and carbonic anhydrase ( ca ) content provide a potentially suitable model for the dissection of coordinate gene expression , the magnitude of fetal vs adult differences in ca i and ca ii levels was examined in ... | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
90,
100
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
103,
106
]
} |
in order to bolster the argument that parallel developmental changes in erythrocyte adult hemoglobin ( hba ) and carbonic anhydrase ( ca ) content provide a potentially suitable model for the dissection of coordinate gene expression , the magnitude of fetal vs adult differences in ca i and ca ii levels was examined in ... | NA | {
"id": "C0007033",
"name": "ca i",
"pos": [
282,
286
]
} | {
"id": "C0007028",
"name": "ca",
"pos": [
396,
398
]
} |
in order to bolster the argument that parallel developmental changes in erythrocyte adult hemoglobin ( hba ) and carbonic anhydrase ( ca ) content provide a potentially suitable model for the dissection of coordinate gene expression , the magnitude of fetal vs adult differences in ca i and ca ii levels was examined in ... | NA | {
"id": "C0007034",
"name": "ca ii",
"pos": [
291,
296
]
} | {
"id": "C0007028",
"name": "ca",
"pos": [
396,
398
]
} |
in response to insulin-induced hypoglycemia , significant increases in epinephrine , norepinephrine , cortisol , and growth hormone were measured in all subjects , while in five of the six patients glucagon levels did not increase at all . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
71,
82
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
85,
99
]
} |
growth hormone , glucagon , epinephrine , and norepinephrine concentrations showed normal nocturnal and early morning patterns during both study nights . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
28,
39
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
46,
60
]
} |
the glycosidases , n-acetylglucosaminidase and galactosidase , had similar activities in the livers of both groups of rats . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
4,
16
]
} | {
"id": "C0016955",
"name": "galactosidase",
"pos": [
47,
60
]
} |
since cl- substitution by an impermeant anion does not inhibit the stimulation of insulin release by all agents , the role of cl- ions does not appear to be restricted to a chemiosmotic mechanism of exocytosis . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
40,
45
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
130,
134
]
} |
plasma insulin , proinsulin , and c-peptide responses to 25 g glucose orally and intravenously administered were measured in 10 healthy males . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
17,
27
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
34,
43
]
} |
during jejunal perfusion of normal subjects with isotonic mannitol-saline containing glucose , maltose or sucrose ( 112 mmol/l ) , monosaccharide absorption from disaccharides was greater than expected from the intraluminal concentration of free monosaccharides , and water secretion was greater than with glucose . | NA | {
"id": "C0024658",
"name": "maltose",
"pos": [
95,
102
]
} | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
162,
175
]
} |
during jejunal perfusion of normal subjects with isotonic mannitol-saline containing glucose , maltose or sucrose ( 112 mmol/l ) , monosaccharide absorption from disaccharides was greater than expected from the intraluminal concentration of free monosaccharides , and water secretion was greater than with glucose . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
106,
113
]
} | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
162,
175
]
} |
the results favour sequential hydrolysis-absorption whereby high concentrations of monosaccharide accumulate at the brush border and promote sugar uptake by conventional rather than 'disaccharidase-related ' transport , and stimulate water secretion by local osmotic effects . | NA | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
83,
97
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
141,
146
]
} |
beer and wine but not whisky and pure ethanol do stimulate release of gastrin in humans . | NA | {
"id": "C0004922",
"name": "beer",
"pos": [
0,
4
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
38,
45
]
} |
beer and wine but not whisky and pure ethanol do stimulate release of gastrin in humans . | NA | {
"id": "C0043188",
"name": "wine",
"pos": [
9,
13
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
38,
45
]
} |
beer and wine but not whisky and pure ethanol do stimulate release of gastrin in humans . | NA | {
"id": "C0475610",
"name": "whisky",
"pos": [
22,
28
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
38,
45
]
} |
a drink of distilled water ( 250 ml ) and of pure ethanol ( 250 ml or 125 ml in the case of 40 % v/v ethanol ) in concentrations ( 4 , 10 , 20 and 40 % v/v ) normally present in beer , wine , liquor and whisky did not stimulate plasma gastrin levels above basal . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
50,
57
]
} | {
"id": "C0004922",
"name": "beer",
"pos": [
178,
182
]
} |
a drink of distilled water ( 250 ml ) and of pure ethanol ( 250 ml or 125 ml in the case of 40 % v/v ethanol ) in concentrations ( 4 , 10 , 20 and 40 % v/v ) normally present in beer , wine , liquor and whisky did not stimulate plasma gastrin levels above basal . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
50,
57
]
} | {
"id": "C0043188",
"name": "wine",
"pos": [
185,
189
]
} |
a drink of distilled water ( 250 ml ) and of pure ethanol ( 250 ml or 125 ml in the case of 40 % v/v ethanol ) in concentrations ( 4 , 10 , 20 and 40 % v/v ) normally present in beer , wine , liquor and whisky did not stimulate plasma gastrin levels above basal . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
50,
57
]
} | {
"id": "C0475610",
"name": "whisky",
"pos": [
203,
209
]
} |
the effects of adrenaline and noradrenaline infusions on pancreaticoduodenal venous insulin output were studied in anaesthetized normal dogs . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
15,
25
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
30,
43
]
} |
these findings show that , in the normal dog , adrenaline and noradrenaline infusions can produce opposite effects on insulin response depending on the experimental conditions . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
47,
57
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
62,
75
]
} |
the blood glucose and plasma insulin responses to some simple carbohydrates ( glucose , fructose , lactose ) and some complex ones ( apples , potatoes , bread , rice , carrots and honey ) were studied in 32 type 2 ( non-insulin-dependent ) diabetic patients . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
4,
17
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
78,
85
]
} |
blood glucose and plasma insulin were measured at zero time and then at 15 , 30 , 60 , 90 and 120 min after ingestion of 25 g glucose , fructose or lactose , or 30 g honey , 50 g white bread , 125 g white rice or potatoes , 150 g apples or 260 g carrots . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
0,
13
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
126,
133
]
} |
at this time the increases in blood glucose and in plasma insulin were significantly higher after the more refined carbohydrates ( glucose , fructose and lactose ) than after the more complex ones ( apples , potatoes , rice , carrots and honey , -p less than 0.01 ) . | NA | {
"id": "C0005802",
"name": "in",
"pos": [
17,
19
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
131,
138
]
} |
a3/kawakami was derived from ascitic lymphoma cells of a 68-year-old female patient with malignant lymphoma ( non-hodgkin 's lymphoma , diffuse , large cell type ) of the stomach and a4/fukuda was derived from ascitic lymphoma cells of a 52-year-old female patient with double cancer of the colon ( well-differentiated p... | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
89,
107
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
348,
371
]
} |
southern blot hybridization revealed that , in all the transformed cell lines , viral dna sequences were integrated at multiple loci in large-molecular-weight cell dnas . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
80,
89
]
} | {
"id": "C0012854",
"name": "dnas",
"pos": [
164,
168
]
} |
this antibody could arise as a result of either the intermittent spontaneous maturation of clones of antibody to hepatitis b surface antigen forming lymphocytes or exposure to environmental antigens that share epitopes with hepatitis b surface antigen . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
190,
198
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
210,
218
]
} |
a significant difference was observed , however , between the hemodynamic responses to leucine and methionine enkephalins before sodium meclofenamate ( 1 mg/kg ) administration compared to post-meclofenamate induced hemodynamic changes . | NA | {
"id": "C0025041",
"name": "sodium meclofenamate",
"pos": [
129,
149
]
} | {
"id": "C1289957",
"name": "meclofenamate",
"pos": [
194,
207
]
} |
the protective effect of spironolactone has been described previously and we have now demonstrated the activity of 7-mercapto-17-hydroxy-3-oxo-4-androsten-17-propionic acid-lactone . | NA | {
"id": "C0037982",
"name": "spironolactone",
"pos": [
25,
39
]
} | {
"id": "C0022947",
"name": "lactone",
"pos": [
173,
180
]
} |
comparative effects of epinephrine , norepinephrine , and a gentle handling stress on plasma lactate , glucose , and hematocrit levels in the american bullfrog ( rana catesbeiana ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
23,
34
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
37,
51
]
} |
the effects of a single infusion of epinephrine or norepinephrine and of a 2-min handling stress on plasma lactate , glucose , and hematocrit levels were compared in the american bullfrog ( rana catesbeiana ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
36,
47
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
51,
65
]
} |
the infusion of 500 micrograms/kg body weight of norepinephrine caused a lactacidemia that was similar to that which occurred with the same dose of epinephrine , but the hyperglycemia was less . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
49,
63
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
148,
159
]
} |
single-strand dna binding protein ( ssb ) from escherichia coli abolishes transfection of e.coli by viral m13mp2 dna at levels that inhibit transfection by m13mp2 replicative form ( rf ) dna by approx . | NA | {
"id": "C0012939",
"name": "viral",
"pos": [
100,
105
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
187,
190
]
} |
three human dna fragments hybridizing to a mouse cdna plasmid for the acute phase protein amyloid a have been isolated from the human lambda charon 4a phage library . | NA | {
"id": "C0001347",
"name": "acute",
"pos": [
70,
75
]
} | {
"id": "C0002723",
"name": "amyloid a",
"pos": [
90,
99
]
} |
fused proteins possessing insulin antigenic determinants are synthesized and secreted by several strains of escherichia coli k-12 bearing plasmids containing cdna copies of rat proinsulin mrna . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
26,
33
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
177,
187
]
} |
phytohemagglutinin-induced t cell colony ( greater than 50 cells/aggregate ) and cluster ( 10-50 cells/aggregate ) formation was studied by one-stage microagar culture in glass capillaries by peripheral blood mononuclear cells from 26 young healthy individuals ( 20-32 years ) and 26 aging subjects ( greater than 65 yea... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
59,
64
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
192,
226
]
} |
consequently it will not be possible by means of diatoms to prove that a person died by drowning . | NA | {
"id": "C0011065",
"name": "died",
"pos": [
80,
84
]
} | {
"id": "C0013142",
"name": "drowning",
"pos": [
88,
96
]
} |
this sonographic examination enabled differentiation of 166 solid from 40 cystic space-occupying masses : 102 lymphatic node enlargements , 12 primary tumours of the neck , 24 neck cysts , one thymus and epidermoid cyst , on carotid aneurysm , diseases of the salivary glands ( 35 neoplasias , 8 cysts , 9 inflammatory t... | NA | {
"id": "C0014511",
"name": "epidermoid cyst",
"pos": [
204,
219
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
296,
301
]
} |
in case of diseases of the salivary glands , differentiation between salivary calculi , neoplasia , inflammation and cyst ; | NA | {
"id": "C0027651",
"name": "neoplasia",
"pos": [
88,
97
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
117,
121
]
} |
the importance of several amino acids ( glycine , l-glutamic acid , l-serine , taurine and beta-alanine ) in the regulation of the stimulated secretion of tsh was studied in male rats using both peripheral and central administration of the amino acids . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
40,
47
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
240,
251
]
} |
these results and other evidence suggest an inhibitory role for the densely glycosylated 30 amino acid residue c-terminal extension on the beta-subunit of hcg which limits , by steric hindrance , the interaction of the tsh-like hcg 'core ' with thyrotropin receptors . | NA | {
"id": "C0106132",
"name": "beta-subunit",
"pos": [
139,
151
]
} | {
"id": "C0018062",
"name": "hcg",
"pos": [
228,
231
]
} |
the possible role of gastrin on tsh , acth and cortisol secretion was evaluated by intravenous administration of pentagastrin , the carboxyl-terminal tetrapeptide of gastrin ( 0.5 microgram/kg b.w . ) into 12 healthy subjects . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
21,
28
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
113,
125
]
} |
the possible role of gastrin on tsh , acth and cortisol secretion was evaluated by intravenous administration of pentagastrin , the carboxyl-terminal tetrapeptide of gastrin ( 0.5 microgram/kg b.w . ) into 12 healthy subjects . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
21,
28
]
} | {
"id": "C0039659",
"name": "tetrapeptide",
"pos": [
150,
162
]
} |
to determine whether the presence of circulating desialylated glycoproteins reflect the existence and/or the severity of liver disease , 73 patients were evaluated with liver biopsies , conventional liver function tests , and the measurement of the degree of desialylation of two glycoproteins alpha 1-acid glycoprotein ... | NA | {
"id": "C0003987",
"name": "desialylated glycoproteins",
"pos": [
49,
75
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
280,
293
]
} |
the amino acid composition differed from bacterial and mammalian lipoamide dehydrogenases with respect to the content of asx , glx , gly , val , and cys . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
133,
136
]
} |
seven alpha 1 beta 1 contacts are modified by substitutions in positions alpha 30- ( b11 ) glu leads to gln , alpha 34 ( b15 ) thr leads to gln , alpha 35 ( b16 ) -ala leads to thr , alpha 36 ( b17 ) tyr leads to phe , beta 55 ( d6 ) leu leads to ile , beta 119 ( gh2 ) ala leads to ser and beta 125 ( h3 ) glu leads to ... | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
104,
107
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
307,
310
]
} |
further , one alpha 1 beta 2 contact point was changed in beta 39 ( c5 ) gln leads to glu . | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
73,
76
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
86,
89
]
} |
affinity chromatography showed that only a fraction of ceruloplasmin was bound to lens culinaris or lathyrus odoratus lectin-sepharose , whereas nearly all the protein was bound to canavalia ensiformis lectin-sepharose . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
160,
167
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
202,
208
]
} |
this reactivity was abolished after absorption of the antiserum with a perchloric acid extract of human lung to remove cross-reacting antibodies against non-specific cross-reacting antigen ( nca ) ; | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
54,
63
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
134,
144
]
} |
the nuclear antigens present in low concentrations , such as ss-a , proliferating cell nuclear antigen ( pcna ) , rheumatoid arthritis nuclear antigen ( rana ) , and ku antigens , are unique to cell types , and their detection requires special substrates or reagent systems . | NA | {
"id": "C0069115",
"name": "nuclear antigens",
"pos": [
4,
20
]
} | {
"id": "C0072108",
"name": "proliferating cell nuclear antigen",
"pos": [
68,
102
]
} |
the nuclear antigens present in low concentrations , such as ss-a , proliferating cell nuclear antigen ( pcna ) , rheumatoid arthritis nuclear antigen ( rana ) , and ku antigens , are unique to cell types , and their detection requires special substrates or reagent systems . | NA | {
"id": "C0069115",
"name": "nuclear antigens",
"pos": [
4,
20
]
} | {
"id": "C0124761",
"name": "ku antigens",
"pos": [
166,
177
]
} |
finally , identification of the molecular nature of these antigens as rna-protein conjugates and the ability of the antibodies to la/ssb to bind viral-specific rna-protein conjugates provide clues that may lead to elucidation of etiologic events in the development of sle . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
74,
81
]
} | {
"id": "C0042736",
"name": "viral",
"pos": [
145,
150
]
} |
the observation that many of the lymphocytotoxic antibodies in sle are also brain-reactive has led to the hypothesis that central nervous system ( cns ) lupus , like the autoimmune hematologic manifestations of sle , is due to the direct effects of autoantibodies to cell membrane antigens . | NA | {
"id": "C0752332",
"name": "central nervous system",
"pos": [
122,
144
]
} | {
"id": "C0024141",
"name": "sle",
"pos": [
211,
214
]
} |
autoreactive antibodies or immune complexes may accelerate clearance of mature erythrocytes , leukocytes , and platelets from the circulation in patients with rheumatologic and immunologic disorders . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
13,
23
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
27,
43
]
} |
novel laboratory techniques such as the determination of proinsulin , insulin , c-peptide and insulin receptors have allowed further subclassification of diabetes mellitus today as representing a symptom rather than a disease . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
57,
67
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
94,
101
]
} |
novel laboratory techniques such as the determination of proinsulin , insulin , c-peptide and insulin receptors have allowed further subclassification of diabetes mellitus today as representing a symptom rather than a disease . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
57,
67
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
80,
89
]
} |
since nine patients with infantile liver cirrhosis or hepatopathy associated with the pi zz phenotype had been observed in recent years in the children 's hospital of the university of innsbruck , tyrol , the distribution of the pi types and the pim subtypes was determined in the tyrolean population . | NA | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
35,
50
]
} | {
"id": "C0023895",
"name": "hepatopathy",
"pos": [
54,
65
]
} |
it was estimated that incorporation of only a single molecule of gp per vesicle of 6000 lipid molecules may be sufficient to protect the particle from phagocytosis , but there was an apparent antagonism between the suppressive gp and opsonizing antibody as , with more antibody , more gp became necessary to inhibit phag... | NA | {
"id": "C0029122",
"name": "opsonizing antibody",
"pos": [
234,
253
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
269,
277
]
} |
the antigenic characteristics of cytotoxic t cells ( ctl ) and cells mediating antibody-dependent cellular cytotoxicity ( adcc ) were defined using monoclonal antibodies w3/13 , w3/25 and mrc ox8 , and compared with the phenotype of natural killer ( nk ) cells previously defined by these antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
148,
158
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
289,
299
]
} |
160 reacted with the polyclonal ( t , g ) -a -- l specific antibodies , whereas antibodies against 103 monoclonal antibodies did not react with c3h.sw anti- ( t , g ) -a -- l antibodies , but did cross-react with four other monoclonal antibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
59,
69
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
224,
245
]
} |
these cells were previously shown to kill allogeneic target cells from hla-a2- or b7-positive male donors . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
42,
52
]
} |
after 1 dietary week , bp increased from 122 +/- .1 mm hg to approximately 145 mm hg ( p less than 0.001 ) , and there was a concomitant 20 % reduction in urinary norepinephrine ( unev ) and epinephrine ( uev ) excretion ( p less than 0.05 ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
163,
177
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
191,
202
]
} |
perhaps of even greater interest , the neutrophilic leukostasis was observed to progress over the 3 h to a predominantly lymphocytic leukostasis , a dramatically more rapid progression than is typical of such immune complex diseases as serum sickness and the arthus reaction ; | NA | {
"id": "C0020951",
"name": "immune complex diseases",
"pos": [
209,
232
]
} | {
"id": "C0003907",
"name": "arthus",
"pos": [
259,
265
]
} |
one group received a so called `` '' liver-solution '' '' with 45 % branched chain amino acids and reduced aromatic and sulphur-containing amino acids , the other group a conventional solution with 10,5 % branched chain amino acids . | NA | {
"id": "C0002520",
"name": "g amino aci",
"pos": [
137,
148
]
} | {
"id": "C0002521",
"name": "% branched chain amino aci",
"pos": [
203,
229
]
} |
amino acid imbalances typically in sepsis -- elevation of aromatic and sulphur-containing amino acids as well as alanine and proline , normal or decreased branched chain amino acids -- could be observed only to some extend , because the influence of preceding operative trauma was overlapping . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
90,
101
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
113,
120
]
} |
amino acid imbalances typically in sepsis -- elevation of aromatic and sulphur-containing amino acids as well as alanine and proline , normal or decreased branched chain amino acids -- could be observed only to some extend , because the influence of preceding operative trauma was overlapping . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
90,
101
]
} | {
"id": "C0002521",
"name": "branched chain",
"pos": [
155,
169
]
} |
like the enzyme from s. mutans , the enzyme from s. sanguis required a divalent cation , mg2+ or mn2+ , and a monovalent cation , k+ or nh4+ , for activity , and it was strongly inhibited by pi . | NA | {
"id": "C0007448",
"name": "divalent",
"pos": [
71,
79
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
121,
127
]
} |
sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis showed that the purified enterotoxin consisted of subunits a and b , identical to those of cholera enterotoxin , and ouchterlony double gel diffusion tests indicated that the two toxins were immunologically identical . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
88,
99
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
242,
248
]
} |
when sets of immune sera were tested , some sera reacted anomalously , mediating significantly higher or lower rates than expected on the basis of their antibody content . | NA | {
"id": "C0020960",
"name": "immune sera",
"pos": [
13,
24
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
153,
161
]
} |
immunological studies by electron microscopic examination of fibril-antibody immunocomplexes , whole bacterial cell agglutination , inhibition of hemagglutination , and immunofluorescence by using antifibril antisera and antibodies demonstrated that strains of typical a. naeslundii ( cluster 5 ) have a specific fibril-... | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
208,
216
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
221,
231
]
} |
one mucoid p. aeruginosa clinical isolate and its derived nonmucoid variant , as well as two other nonmucoid variant p. aeruginosa strains ( all from cystic fibrosis patients ) , showed similar production of five differently migrating proteases ( p1 to p5 , numbered according to increasing net negative charge ) in ph 9... | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
235,
244
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
334,
342
]
} |
since both virus particles and virus-infected cells may be present in the blood during hsv infection , the induction of this type of immune regulation may influence the outcome of both acute and latent hsv infections . | NA | {
"id": "C0019348",
"name": "hsv",
"pos": [
87,
90
]
} | {
"id": "C0019372",
"name": "hsv infections",
"pos": [
202,
216
]
} |
the disaccharides sophorose and maltose inhibited hemagglutination by specific antiserum of sheep erythrocytes coated with lipoglycan from a. granularum . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
4,
17
]
} | {
"id": "C0024658",
"name": "maltose",
"pos": [
32,
39
]
} |
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