text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
pf-treated eca no longer coated erythrocytes but still reacted with eca antibodies in immunoelectrophoresis tests with monospecific antiserum to eca , although differences were noted between the precipitation patterns of pf-treated and untreated eca . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
72,
82
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
132,
141
]
} |
tinidazole has been shown to be efficacious in protozoal infections such as trichomonal vaginitis , amoebiasis and giardiasis . | NA | {
"id": "C0033740",
"name": "protozoal",
"pos": [
47,
56
]
} | {
"id": "C0002438",
"name": "amoebiasis",
"pos": [
100,
110
]
} |
by agglutination studies of erythrocytes with various set-ups of these antigens as well as by inhibition studies using synthetic saccharide derivatives and by coating non-agglutinable erythrocytes with a synthetic glycolipid , the minimal receptor structure was identified as the alpha-d-galp- ( 1-4 ) -beta-d-galp moiet... | NA | {
"id": "C0017950",
"name": "glycolipid",
"pos": [
214,
224
]
} | {
"id": "C0017978",
"name": "glycosphingolipids",
"pos": [
359,
377
]
} |
absorption studies of the im sera with bovine and sheep erythrocytes and guinea pig tissues revealed that this antigen was identical with or closely related to the previously described b antigen of the paul-bunnel ( p-b ) antigenic complex and distinct from heterophile antigens of hanganutziu-deicher ( h-d ) and of for... | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
222,
231
]
} | {
"id": "C0003333",
"name": "heterophile antigens",
"pos": [
258,
278
]
} |
human peripheral blood mononuclear cells contain therefore a subpopulation of cells that can differentiate into mast cells-like cells under specific in vitro culture conditions . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
6,
40
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
128,
133
]
} |
mercaptoethanol treatment of lavage fluid had little effect on the antibody titer , suggesting that igg , and possibly iga , were the predominant immunoglobulin classes in the antigen-specific antibody pool throughout the course of the serial lavage study . | NA | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
146,
168
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
193,
201
]
} |
in vitro and in vivo effect of sisomicin and gentamycin on polymorphonuclear chemotaxis and phagocytosis . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
31,
40
]
} | {
"id": "C0017436",
"name": "gentamycin",
"pos": [
45,
55
]
} |
ten patients with acute bacterial infections were studied to demonstrate the influence of two aminoglycosides , sisomicin and gentamycin on polymorphonuclear ( pmn ) chemotactic and phagocytic functions . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
94,
109
]
} | {
"id": "C0017436",
"name": "gentamycin",
"pos": [
126,
136
]
} |
ten patients with acute bacterial infections were studied to demonstrate the influence of two aminoglycosides , sisomicin and gentamycin on polymorphonuclear ( pmn ) chemotactic and phagocytic functions . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
112,
121
]
} | {
"id": "C0017436",
"name": "gentamycin",
"pos": [
126,
136
]
} |
five of these subjects were treated with gentamycin and five with sisomicin both at a dosage of 2.5 mg kg-1 day-1 . | NA | {
"id": "C0017436",
"name": "gentamycin",
"pos": [
41,
51
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
66,
75
]
} |
after therapy , no significant difference in basic values was found in either the gentamycin treated or in the sisomicin treated group . | NA | {
"id": "C0017436",
"name": "gentamycin",
"pos": [
82,
92
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
111,
120
]
} |
the concomitant significant rise of noradrenaline , adrenaline , acth , and hgh and the parallel fall in plasma insulin suggest that all these hormones are involved in the adjustment of exercise-induced lipolysis . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
36,
49
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
52,
62
]
} |
adrenergic agonists stimulate the synthesis of cyclic amp by incubated rabbit corneas with the following order of potency : isoproterenol greater than epinephrine greater than norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
151,
162
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
176,
190
]
} |
mixed tumors , clear cell tumors , plasmacytoid ( hyaline cell ) and fibroblastic myoepitheliomas , and terminal duct adenocarcinomas are examples of tumors in which the myoepithelial cell is prominent or dominant . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
21,
25
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
69,
81
]
} |
acral lentiginous melanoma , while demonstrating a radial growth phase which is histologically similar to that of lentigo maligna , appears biologically more similar to superficially spreading malignant melanoma once the vertical growth phase supervenes . | NA | {
"id": "C0149722",
"name": "lentigo maligna",
"pos": [
114,
129
]
} | {
"id": "C0025202",
"name": "malignant melanoma",
"pos": [
193,
211
]
} |
since pma and sta are known as strong precipitating agents of quaternary ammonium compounds ( cations ) it is supposed that they have insolubilized in situ the acetylcholine ( ach ) of the synaptic vesicles by means of a rapid ionic interaction . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
94,
101
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
227,
232
]
} |
ultrastructural results are presented , histogenesis and classification of olfactory neuroblastomas in neuroepithelioma , neurocytoma and neuroblastoma are discussed . | NA | {
"id": "C0206717",
"name": "olfactory neuroblastomas",
"pos": [
75,
99
]
} | {
"id": "C0027819",
"name": "neuroblastoma",
"pos": [
138,
151
]
} |
similarly hla-cw8 antibodies were detected in hla-b14 antisera , which reacted on all hla-cw5-positive donor cells . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
18,
28
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
54,
62
]
} |
the latter studies showed that specificity detected by the mc-26.1 antibody coprecipitated with determinants detected by conventional anti-mb3 and mt3 , but not with hla-dr4 antisera . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
67,
75
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
174,
182
]
} |
it has now been demonstrated that such eb virus-specific cytotoxic t cells may also be reactivated by stimulation with allogeneic virus-transformed cells provided that there is no mismatch of the hla-a and b antigens between the responder and stimulator cell donors . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
119,
129
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
254,
258
]
} |
inhibition of fbm by pge2 , combined with previous results showing stimulation of fbm by pg synthetase inhibitors , suggests that endogenous pg may inhibit breathing movements in utero and that a change in pg metabolism may contribute to the change in control of breathing at birth . | NA | {
"id": "C0033554",
"name": "pg",
"pos": [
21,
23
]
} | {
"id": "C0033555",
"name": "a",
"pos": [
273,
274
]
} |
indicators of physical activity had a positive correlation ( p less than 0.02 ) with high-density-lipoprotein cholesterol and negative correlations ( p less than 0.05 ) with the total serum cholesterol/high-density-lipoprotein cholesterol and low-density-lipoprotein cholesterol/high-density-lipoprotein cholesterol rati... | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
110,
121
]
} | {
"id": "C0023824",
"name": "low-density-lipoprotein",
"pos": [
243,
266
]
} |
indicators of physical activity had a positive correlation ( p less than 0.02 ) with high-density-lipoprotein cholesterol and negative correlations ( p less than 0.05 ) with the total serum cholesterol/high-density-lipoprotein cholesterol and low-density-lipoprotein cholesterol/high-density-lipoprotein cholesterol rati... | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
110,
121
]
} | {
"id": "C0023822",
"name": "density-lipoprotein",
"pos": [
284,
303
]
} |
high-activity subjects had lower ( p less than 0.05 ) total serum cholesterol/high-density-lipoprotein cholesterol and low-density-lipoprotein cholesterol/high-density-lipoprotein cholesterol ratios than less active subjects . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
66,
77
]
} | {
"id": "C0023824",
"name": "low-density-lipoprotein",
"pos": [
119,
142
]
} |
high-activity subjects had lower ( p less than 0.05 ) total serum cholesterol/high-density-lipoprotein cholesterol and low-density-lipoprotein cholesterol/high-density-lipoprotein cholesterol ratios than less active subjects . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
66,
77
]
} | {
"id": "C0023822",
"name": "density-lipoprotein",
"pos": [
160,
179
]
} |
nutrient digestibility of bscp was estimated by a least-squares analysis regressing apparent digestibility of each nutrient on bscp content . | NA | {
"id": "C0012177",
"name": "nutrient",
"pos": [
0,
8
]
} | {
"id": "C0033684",
"name": "bscp",
"pos": [
127,
131
]
} |
in none of 40 patients receiving rpm did resistance to any of the components develop , while in three of 20 patients receiving co-t resistance to tmp or smz emerged during treatment . | NA | {
"id": "C0041044",
"name": "co-t",
"pos": [
127,
131
]
} | {
"id": "C0038689",
"name": "smz",
"pos": [
153,
156
]
} |
for three strains , the loss or reduction of aminoglycoside-modifying enzymes in the sensitive variants was accompanied by an increase in intracellular gentamicin accumulation , confirming that modification of the antibiotic was associated with its impaired uptake . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
45,
59
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
152,
162
]
} |
the sensitive variants of the two remaining strains showed no increase in [ 3h ] gentamicin accumulation but still produced aminoglycoside-modifying enzymes , and it is suggested that the broad-spectrum aminoglycoside resistance of these two strains is due to some hitherto undescribed mechanisms of resistance rather th... | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
81,
91
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
203,
217
]
} |
multiresistant strains of enterobacter cloacae showed a high level of resistance to cefotetan in common with other cephalosporins such as cefuroxime , cefamandole and cefoxitin , but were sensitive to ceftazidime and cefotaxime . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
138,
148
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
217,
227
]
} |
the above antibiotics all also produced a bactericidal effect against haemophilus influenzae in serum , and the macrolides erythromycin and rosaramicin destroyed haemophilus in serum more rapidly than did ampicillin or amoxycillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
205,
215
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
219,
230
]
} |
cefotetan is a new cephamycin whose interaction with a group of eight beta-lactamases isolated from various gram-negative bacteria has been studied . | NA | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
0,
9
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
19,
29
]
} |
these techniques revealed that cefotetan behaves very much like cefoxitin ( another cephamycin ) and also like cefotaxime and moxalactam . | NA | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
31,
40
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
84,
94
]
} |
these techniques revealed that cefotetan behaves very much like cefoxitin ( another cephamycin ) and also like cefotaxime and moxalactam . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
64,
73
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
84,
94
]
} |
the antibacterial activity of cefotetan , a new cephamycin , was compared with that of cephalothin , cefoxitin , cefamandole , cefoperazone and cefotaxime on 12 substrains of escherichia coli k12 bm13 harbouring single and multi-copy plasmids coding for plasmid-mediated beta-lactamases tem , shvi , oxa-i and oxa-iii . | NA | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
30,
39
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
48,
58
]
} |
the antibacterial activity of cefotetan , a new cephamycin , was compared with that of cephalothin , cefoxitin , cefamandole , cefoperazone and cefotaxime on 12 substrains of escherichia coli k12 bm13 harbouring single and multi-copy plasmids coding for plasmid-mediated beta-lactamases tem , shvi , oxa-i and oxa-iii . | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
48,
58
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
101,
110
]
} |
the antibacterial activity of cefotetan , a new cephamycin , was compared with that of cephalothin , cefoxitin , cefamandole , cefoperazone and cefotaxime on 12 substrains of escherichia coli k12 bm13 harbouring single and multi-copy plasmids coding for plasmid-mediated beta-lactamases tem , shvi , oxa-i and oxa-iii . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
113,
124
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
127,
139
]
} |
the 99 % inhibitory concentrations ( ic99 ) for the recipient strain were increased in proportion to the enzyme activity in the case of cefamandole and cefoperazone . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
136,
147
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
152,
164
]
} |
no new pbps were detected using [ 14c ] cefotetan , suggesting that the compound exerts its antibacterial effect by a mechanism similar to the other cephamycins . | NA | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
40,
49
]
} | {
"id": "C0007736",
"name": "cephamycins",
"pos": [
149,
160
]
} |
cefotetan inhibited about two-thirds of enterobacter strains at 16 mg/l . beta-lactamases of enterobacter cloacae highly resistant to cefotetan inactivated this cephamycin . | NA | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
0,
9
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
161,
171
]
} |
cefotetan , a new cephamycin antibiotic , was evaluated for the treatment of lower respiratory tract infections . | NA | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
0,
9
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
18,
28
]
} |
the activity in vitro of the new cephamycin , cefotetan , was compared with that of cephalothin , cefoxitin , cefuroxime and cefotaxime against 226 recently isolated gram-negative pathogens ( 207 enterobacteriaceae and 19 acinetobacter ) . | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
33,
43
]
} | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
46,
55
]
} |
the activity in vitro of the new cephamycin , cefotetan , was compared with that of cephalothin , cefoxitin , cefuroxime and cefotaxime against 226 recently isolated gram-negative pathogens ( 207 enterobacteriaceae and 19 acinetobacter ) . | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
33,
43
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
98,
107
]
} |
the activity in vitro of the new cephamycin , cefotetan , was compared with that of cephalothin , cefoxitin , cefuroxime and cefotaxime against 226 recently isolated gram-negative pathogens ( 207 enterobacteriaceae and 19 acinetobacter ) . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
110,
120
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
125,
135
]
} |
the in-vitro activity of cefotetan , a recently developed cephamycin , was investigated under various experimental conditions . | NA | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
25,
34
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
58,
68
]
} |
the cephamycin , cefotetan , was compared with other beta-lactam antibiotics including the monocyclic beta-lactam , azthreonam , against a total of 277 recent clinical isolates . | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
4,
14
]
} | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
17,
26
]
} |
the cephamycin , cefotetan , was compared with other beta-lactam antibiotics including the monocyclic beta-lactam , azthreonam , against a total of 277 recent clinical isolates . | NA | {
"id": "C0026458",
"name": "beta-lactam antibiotics",
"pos": [
53,
76
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
102,
113
]
} |
the object of this investigation was to evaluate the antibacterial properties of the cephalosporins cefoxitin , cefoperazone , cefotaxime and of gentamicin , in comparison with cefotetan , a new cephamycin with a high degree of stability to beta-lactamases . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
85,
99
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
195,
205
]
} |
the object of this investigation was to evaluate the antibacterial properties of the cephalosporins cefoxitin , cefoperazone , cefotaxime and of gentamicin , in comparison with cefotetan , a new cephamycin with a high degree of stability to beta-lactamases . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
100,
109
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
195,
205
]
} |
the object of this investigation was to evaluate the antibacterial properties of the cephalosporins cefoxitin , cefoperazone , cefotaxime and of gentamicin , in comparison with cefotetan , a new cephamycin with a high degree of stability to beta-lactamases . | NA | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
177,
186
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
195,
205
]
} |
the activity of the 7 alpha-methoxycephalosporin , cefotetan was determined against 365 infecting isolates of gentamicin- and multiply-resistant gram-negative aerobic bacilli , and compared with those of cefuroxime , cefoxitin , cephradine , cefotaxime , ceftriaxone and ceftazidime . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
204,
214
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
242,
252
]
} |
the activity of the 7 alpha-methoxycephalosporin , cefotetan was determined against 365 infecting isolates of gentamicin- and multiply-resistant gram-negative aerobic bacilli , and compared with those of cefuroxime , cefoxitin , cephradine , cefotaxime , ceftriaxone and ceftazidime . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
242,
252
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
255,
266
]
} |
overall , the activities of cefotetan were similar to those of cefotaxime , ceftriaxone and ceftazidime but ceftazidime was also active against the majority of pseudomonas , acinetobacter and enterobacter . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
63,
73
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
76,
87
]
} |
manipulation of carbon source nutrition produced a physiological state of sensitivity to p-fluorophenylalanine and m-fluorophenylalanine , each a specific antimetabolite of l-phenylalanine . | NA | {
"id": "C0030137",
"name": "p-fluorophenylalanine",
"pos": [
89,
110
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
175,
188
]
} |
class iii strains lack both cytochromes bfdh and bnr but overproduce cytochrome d of the aerobic pathway even under anaerobic conditions in the presence of nitrate . | NA | {
"id": "C0010798",
"name": "cytochromes",
"pos": [
28,
39
]
} | {
"id": "C0056960",
"name": "cytochrome d",
"pos": [
69,
81
]
} |
during lysogenization , mx8 dna was cut at a specific site ( attp ) on phage dna , and we have concluded that genetic recombination between attp and a bacterial dna site ( attb ) leads to integration of mx8 dna and formation of stable mx8 prophage . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
28,
31
]
} | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
151,
164
]
} |
an isogenic pair of rela+ and rela strains of escherichia coli b/r with a mutation in the rna polymerase subunit gene rpob ( rifr ) was isolated in which the relationship between guanosine tetraphosphate ( ppgpp ) concentration and stable rna ( rrna , trna ) gene activity was altered . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
90,
93
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
245,
249
]
} |
among the enzymes of fructose catabolism , naf ( 10 mm ) inhibited enolase in vitro by 98 % and gluconate 6-phosphate dehydratase by 87 % . | NA | {
"id": "C0031691",
"name": "enolase",
"pos": [
67,
74
]
} | {
"id": "C0020239",
"name": "dehydratase",
"pos": [
118,
129
]
} |
streptococcus lactis k1 has the capacity to grow on many sugars , including sucrose and lactose , in the presence of high levels ( greater than 500 mm ) of 2-deoxy-d-glucose . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
57,
63
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
76,
83
]
} |
the subunit consisted of a single polypeptide chain of 129 amino acid residues , with alanine and serine at the amino ( n ) - and carboxyl ( c ) -terminus , respectively . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
59,
69
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
86,
93
]
} |
among the anions , monovalent anions such as halogen ions and azide inhibited ionization of the phenolic hydroxyl group of the substrate ( p-hydroxybenzoate ) on binding with the enzyme . substrate complex of p-hydroxybenzoate hydroxylase , without dissociating the substrate from the enzyme . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
10,
16
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
53,
57
]
} |
on the other hand , multivalent anions ( anions of polybasic acids ) , such as inorganic phosphate , borate , and sulfate , did not inhibit the ionization . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
32,
38
]
} | {
"id": "C0031603",
"name": "inorganic phosphate",
"pos": [
79,
98
]
} |
on the other hand , multivalent anions ( anions of polybasic acids ) , such as inorganic phosphate , borate , and sulfate , did not inhibit the ionization . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
32,
38
]
} | {
"id": "C0006007",
"name": "borate",
"pos": [
101,
107
]
} |
on the other hand , multivalent anions ( anions of polybasic acids ) , such as inorganic phosphate , borate , and sulfate , did not inhibit the ionization . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
32,
38
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
114,
121
]
} |
these results indicate that the monovalent and multivalent anions probably bind to the sites in the enzyme which interact , respectively , with the pyrophosphate and 2'-phosphate moieties of nadph . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
59,
65
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
169,
178
]
} |
only mg2+ was required as an activating cation , and other divalent cations inhibited the activity to some degree . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
40,
46
]
} | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
59,
75
]
} |
the nucleic acid of the phage was linear , double stranded dna of molecular weight 4 x 10 ( 7 ) . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
4,
16
]
} | {
"id": "C0012854",
"name": "double stranded dna",
"pos": [
43,
62
]
} |
the affinities of these enzymes under various conditions were measured quantitatively by frontal chromatography in terms of the dissociation constant ( kd ) of the enzyme-immobilized ligand complex . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
24,
31
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
164,
170
]
} |
the sulfate efflux rate was dependent on temperature , ph and anion species of the cell suspending medium . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
4,
11
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
62,
67
]
} |
the results obtained in this study suggest that sulfate anions were transported by a facilitated transport system ( s ) , and that some membrane protein ( s ) is involved in the anion transport system ( s ) of ah-66 cells . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
48,
55
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
56,
62
]
} |
new 434-specific dna binding protein copurified with the 434 tof protein from lambda imm434ci dv carrier cells of escherichia coli . | NA | {
"id": "C0012940",
"name": "dna binding protein",
"pos": [
17,
36
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
65,
72
]
} |
the apparent molecular weight of the new 434-specific dna binding protein is 9,000 to 9,500 , a little higher than that of the 434 tof protein , as estimated by sds gel electrophoresis . | NA | {
"id": "C0012940",
"name": "dna binding protein",
"pos": [
54,
73
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
135,
142
]
} |
both enzyme activities require atp and mg2+ for the degradation of double- and single-stranded dnas , and degrade denatured dna about 1.5 times faster than native dna . | NA | {
"id": "C0012935",
"name": "single-stranded dnas",
"pos": [
79,
99
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
163,
166
]
} |
during progressive digestion mononucleosomes from chromatin retained h1 histone and a dna length of 165 base pairs , whereas those from nuclei released h1 histone and the length of their dna decreased to 140 base pairs at an early stage of digestion . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
84,
89
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
187,
190
]
} |
when phosphoglycerides such as phosphatidylcholine and phosphatidylethanolamine on the microsomal membrane were hydrolyzed by phospholipase c of c. perfringens , the activities of glucose-6-p phosphohydrolase and glucose-6-p : glucose phosphotransferase both decreased with or without subsequent exposure to taurocholate... | NA | {
"id": "C0162448",
"name": "phosphoglycerides",
"pos": [
5,
22
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
31,
50
]
} |
when phosphoglycerides such as phosphatidylcholine and phosphatidylethanolamine on the microsomal membrane were hydrolyzed by phospholipase c of c. perfringens , the activities of glucose-6-p phosphohydrolase and glucose-6-p : glucose phosphotransferase both decreased with or without subsequent exposure to taurocholate... | NA | {
"id": "C0162448",
"name": "phosphoglycerides",
"pos": [
5,
22
]
} | {
"id": "C0031618",
"name": "phosphatidylethanolamine",
"pos": [
55,
79
]
} |
on the other hand , the effect of this protein on the turbidity increase was not so prominent when microtubules were assembled from microtubule proteins consisting of tubulin and microtubule-associated proteins . | NA | {
"id": "C0026042",
"name": "microtubule proteins",
"pos": [
132,
152
]
} | {
"id": "C0041348",
"name": "tubulin",
"pos": [
167,
174
]
} |
on the other hand , the effect of this protein on the turbidity increase was not so prominent when microtubules were assembled from microtubule proteins consisting of tubulin and microtubule-associated proteins . | NA | {
"id": "C0026042",
"name": "microtubule proteins",
"pos": [
132,
152
]
} | {
"id": "C0026045",
"name": "microtubule-associated proteins",
"pos": [
179,
210
]
} |
the acidic oligosaccharides were fractionated into a fraction of high molecular weight and a series of oligosaccharides in which di- and trisaccharides containing sialic acid were dominant . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
11,
27
]
} | {
"id": "C0041102",
"name": "trisaccharides",
"pos": [
137,
151
]
} |
the increase in viscosity with increasing cation concentration was semi-quantitatively interpreted in terms of chain growth and branching due to intermolecular bridging of the carboxylate groups by the metal ions . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
42,
48
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
208,
212
]
} |
a simple radiologic sign is here described which may uncover rotational fracture deformity : in the absence of comminution , whenever the diameter of a long bone changes abruptly across a fracture line , a significant rotational deformity must be considered . | NA | {
"id": "C0476171",
"name": "comminution",
"pos": [
111,
122
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
188,
196
]
} |
we also show that the maps ( map-1 , map-2 , and tau factors ) and other high molecular weight polypeptides do not contain significant amounts of atpase activity . | NA | {
"id": "C0026045",
"name": "maps",
"pos": [
22,
26
]
} | {
"id": "C0085401",
"name": "tau factors",
"pos": [
49,
60
]
} |
these studies indicate that the principal atpase activity associated with microtubules is not contained in high molecular weight proteins such as dynein or maps and support the hypothesis that the 50-kdalton atpase is a membrane protein and may be derived from mitochondria or membrane vesicles with f-1-like atpase acti... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
129,
137
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
220,
236
]
} |
synapsin i ( formerly referred to as protein i ) is the collective name for two almost identical phosphoproteins , synapsin ia and synapsin ib ( protein ia and protein ib ) , present in the nervous system . | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
97,
112
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
160,
167
]
} |
the block in milk protein gene expression was not restricted to translational or posttranslational events but also included transcription , since no casein mrna accumulated in these cells . | NA | {
"id": "C0026138",
"name": "milk protein",
"pos": [
13,
25
]
} | {
"id": "C0007332",
"name": "casein",
"pos": [
149,
155
]
} |
however , beta-xyloside inhibits total proteoglycan-associated glycosaminoglycan synthesis by 50 % , and also stimulates synthesis of large amounts of free chondroitin ( dermatan ) sulfate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
63,
80
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
156,
167
]
} |
however , beta-xyloside inhibits total proteoglycan-associated glycosaminoglycan synthesis by 50 % , and also stimulates synthesis of large amounts of free chondroitin ( dermatan ) sulfate . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
156,
167
]
} | {
"id": "C0011602",
"name": "dermatan",
"pos": [
170,
178
]
} |
( a ) we have been unable to inhibit branching activity by adding large amounts of chondroitin ( dermatan ) sulfate , extracted from beta-xyloside-treated cultures , to the medium of salivary rudiments undergoing morphogenesis . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
83,
94
]
} | {
"id": "C0011602",
"name": "dermatan",
"pos": [
97,
105
]
} |
fluorographs of the labeled proteins , resolved on two-dimensional ( 2-d ) charge/sds and one-dimensional ( 1-d ) sds-urea gradient gels , demonstrated that five to six of the large subunit proteins are products of chloroplast protein synthesis while 26 to 27 of the large subunit proteins are synthesized on cytoplasmic... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
28,
36
]
} | {
"id": "C0599220",
"name": "subunit proteins",
"pos": [
273,
289
]
} |
the 20 ribosomal proteins shown to be made in the chloroplast of chlamydomonas more than double the number of proteins known to be synthesized in the chloroplast of this alga . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
7,
25
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
110,
118
]
} |
using cell permeabilization , a technique which allows addition of exogenously supplied radiolabeled sugar nucleotides to serve as direct glycosyl donors , oligosaccharide biosynthesis was examined in fibroblasts obtained from normal and cystic fibrosis ( cf ) subjects . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
6,
10
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
201,
212
]
} |
the uptake of xylose into protein was the same for both normal and cf cells , but permeable cf fibroblasts incorporated statistically greater amounts of sugar from udp-galactose and udp-glucuronic acid . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
70,
75
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
95,
106
]
} |
this and the fact that preincubation of cf cells with the appropriate cold sugar nucleotide eliminated the differences in incorporation between the normal and cf cells suggested that cf fibroblasts had more cell surface acceptor than the normal cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
186,
197
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
238,
250
]
} |
maximal rates of superoxide ( o-2 ) release , and the cytochemical locales of peroxide staining in resident , elicited , and activated macrophages have been determined . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
17,
27
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
78,
86
]
} |
effect of topically administered epinephrine , norepinephrine , and acetylcholine on cerebrocortical circulation and the nad/nadh redox state . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
33,
44
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
47,
61
]
} |
cerebrocortical vascular volume ( cvv ) and the diameter of the pial vessels were decreased , and nadh was oxidized by concentrations of epinephrine and norepinephrine as low as 3 x 10 ( -8 ) m . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
137,
148
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
153,
167
]
} |
diagnostic and surgical features of lateral cervical chemodectomas are discussed in relation to a personal series of 13 patients with carotid body tumors and 7 with tumors of the intravagal glomus . | NA | {
"id": "C0030422",
"name": "chemodectomas",
"pos": [
53,
66
]
} | {
"id": "C0007279",
"name": "carotid body tumors",
"pos": [
134,
153
]
} |
preliminary data on urinary sialic acids indicated that cancerous patients gave significantly higher levels of urinary n-acetylneuraminic acid than normal subjects . | NA | {
"id": "C0037025",
"name": "sialic acids",
"pos": [
28,
40
]
} | {
"id": "C0067762",
"name": "n-acetylneuraminic acid",
"pos": [
119,
142
]
} |
experiments with [ 3h ] glucose and the colorimetric test ( thiobarbituric acid ) normally used to determine the extent of non-enzymatic glycosylation , as well as an increase of this component in diabetic samples compared with normoglycemic ones and a significant linear correlation with hb-a1c , indicate that this com... | NA | {
"id": "C0019016",
"name": "a",
"pos": [
32,
33
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
442,
452
]
} |
previous studies in patients with idiopathic hyperprolactinemia ( ih ) that have suggested the presence of decreased central dopaminergic tone have assumed normal responsiveness of lactotrophs to dopamine ( da ) . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
125,
137
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
196,
204
]
} |
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