text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
we have examined da sensitivity in 17 women with ih and 19 female controls by evaluating the plasma prl responses to successive infusions of increasing concentrations of da ( 4 , 40 , and 400 ng/kg . min ) as well as to a dopaminergic agonist , bromocriptine ( 2.5 mg , orally ) , and to a dopaminergic agonist , bromocr... | NA | {
"id": "C0013030",
"name": "da",
"pos": [
17,
19
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
358,
370
]
} |
to determine the basis for the decline in testosterone production by the aged testis , intratesticular unconjugated steroids , including testosterone , pregnenolone ( 3 beta-hydroxy-5-pregnen-20-one ) , 17 alpha-hydroxypregnenolone ( 3 beta,17 alpha-dihydroxy-5-pregnen-20-one ) , dehydroepiandrosterone ( 3 beta-hydroxy... | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
152,
164
]
} | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
203,
231
]
} |
study of bioconversion of [ 3h ] pregnenolone to delta 4 steroids , 17 alpha-hydroxysteroids , and c19 steroids as well as analysis of the relative amounts of intratesticular steroids , as determined by ria , revealed no apparent differences in the process of microsomal steroidogenesis in elderly compared to that in yo... | NA | {
"id": "C0020393",
"name": "hydroxysteroids",
"pos": [
77,
92
]
} | {
"id": "C0038317",
"name": "steroids",
"pos": [
175,
183
]
} |
in contrast , when type-specific antisera prepared commercially were used , results were often obscure , even contradictory , because of antibody cross-reactions . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
33,
41
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
137,
145
]
} |
reagent-impregnated filter paper replica methods are described which can be used to detect all penicillinase ( beta-lactamase ) -producing neisseria gonorrhoeae ( ppng ) colonies in an entire population of neisseria gonorrhoeae growing on primary isolation plates . | NA | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
95,
108
]
} | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
111,
125
]
} |
the method depends on the production of cell-associated virus at 34 degrees c and subsequently , on the separation of cellular dna and viral dna by dounce homogenization and the removal of nuclei by centrifugation . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
127,
130
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
135,
144
]
} |
the method obviates the use of radioactive isotopes , and the viral dna is effectively free of interfering cellular dna . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
62,
71
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
116,
119
]
} |
dental lamina epithelium appears to have a particular predisposition for cystic degeneration and is probably the source of other neoplasms and hamartomas seen in the gingiva . | NA | {
"id": "C0027651",
"name": "neoplasms",
"pos": [
129,
138
]
} | {
"id": "C0018552",
"name": "hamartomas",
"pos": [
143,
153
]
} |
pathological conditions included brachial cleft cyst , laryngocele , thyroglossal duct cyst , cavernous lymphangioma , necrotic lymphadenopathy , and asymmetric jugular veins . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
48,
52
]
} | {
"id": "C0040124",
"name": "thyroglossal duct cyst",
"pos": [
69,
91
]
} |
bovine serum lipoproteins were fractionated into high density and low and very low density lipoproteins by precipitation with sodium phosphotungstate and magnesium chloride . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
13,
25
]
} | {
"id": "C0023825",
"name": "very",
"pos": [
74,
78
]
} |
an analysis of thin layers of enamel removed from the lesions showed that more fluoride was deposited after two mo of brushing , and that fluoride deposition from the sodium monofluorophosphate was similar to deposition from the sodium fluoride dentifrice . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
79,
87
]
} | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
229,
244
]
} |
we studied an atopic individual whose job-related activities involved strenuous running that often terminated in an episode of syncope and hypotension preceded by cutaneous pruritus , warmth , urticaria , and angioedema . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
193,
202
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
209,
219
]
} |
bentonite-water dispersions , prepared with 82.7 % distilled water and 17.3 % dry bentonite powder by weight , were shaped into standardized models . | NA | {
"id": "C0005018",
"name": "bentonite",
"pos": [
0,
9
]
} | {
"id": "C0776030",
"name": "bentonite powder",
"pos": [
82,
98
]
} |
recent observations that several soluble proteins ( synexin , and albumin ) will act as fusogens are discussed in terms of the relevance to exocytosis in vivo . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
41,
49
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
66,
73
]
} |
leu- and met-enkephalin , which are co-stored with adrenaline in the bovine adrenal medullary cells produce a non-specific inhibition of the nicotine-evoked release of ca , but enhance the basal release of endogenous catecholamines by a mechanism that is ca2+-dependent , stereospecific and reversible by naloxone and na... | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
305,
313
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
318,
328
]
} |
multiple endocrine neoplasia , type iib ( men 2b ) , is comprised of medullary carcinoma of the thyroid , pheochromocytoma , diffuse ganglioneuromatosis of the gastrointestinal tract , and skeletal abnormalities . | NA | {
"id": "C0027662",
"name": "multiple endocrine neoplasia",
"pos": [
0,
28
]
} | {
"id": "C0025269",
"name": "men 2b",
"pos": [
42,
48
]
} |
isozyme patterns of six enzymes , glucose-6-phosphate dehydrogenase , glucosephosphate isomerase , hexokinase , malate dehydrogenase , 6-phosphate dehydrogenase and phosphoglucomutase were examined in electrophoresed homogenates of adult male worms of schistosoma japonicum and s. mansoni . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
0,
7
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
24,
31
]
} |
concomitant with worm rejection was the development of twe-sensitized lymphoid cells which responded by proliferation when stimulated in vitro with twe . | NA | {
"id": "C0018889",
"name": "worm",
"pos": [
17,
21
]
} | {
"id": "C0007894",
"name": "twe",
"pos": [
148,
151
]
} |
the intensity of blue staining of these minor proteins in milk approached that obtained with casein phosphoproteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
46,
54
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
100,
115
]
} |
visual and photometric comparison of tissue sections reacted sequentially with polyclonal or monoclonal antisera and appropriate fluorochromes and mounted with and without pd indicated that pd both prolonged and intensified fluorescence without evident effect on antibody binding . | NA | {
"id": "C0031468",
"name": "pd",
"pos": [
172,
174
]
} | {
"id": "C0048678",
"name": "pd",
"pos": [
190,
192
]
} |
in this study we found that by painting the tails of mice with the hapten trinitrochlorobenzene ( tncb ) , sensitization was induced in certain mouse strains ( balb/c , a/j , and cba -- haplotypes h-2d , h-2a , h-2k , respectively ) , but tolerance resulted from painting the tails of other strains ( c57bl/6 , c57bl/10 ... | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
67,
73
]
} | {
"id": "C0031891",
"name": "trinitrochlorobenzene",
"pos": [
74,
95
]
} |
based on the thymus-derived nature of the neoplastic cells , mf and ss are both classified as cutaneous t-cell lymphoma . | NA | {
"id": "C0036920",
"name": "ss",
"pos": [
68,
70
]
} | {
"id": "C0079773",
"name": "cutaneous t-cell lymphoma",
"pos": [
94,
119
]
} |
in order to detect and characterize antibodies to gluten in human sera , we developed an enzyme immunoassay for class-specific antibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
36,
46
]
} | {
"id": "C0021017",
"name": "class",
"pos": [
112,
117
]
} |
the viral dna detected appeared not to be integrated with host dna and to be isolated in foci . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
4,
13
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
63,
66
]
} |
thirty-one ( 93 % ) of 34 isolates produced both proteases in vitro in comparable amounts ( concentration of protease in culture supernatant : ap , 0.01-480 micrograms/ml ; | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
49,
58
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
109,
117
]
} |
nine clinical isolates of streptococcus faecalis from a university hospital were found to be resistant to high levels ( minimal inhibitory concentration , greater than 2,000 micrograms/ml ) of gentamicin , tobramycin , amikacin , streptomycin , and kanamycin . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
219,
227
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
249,
258
]
} |
in three strains tested , the aminoglycoside resistance was mediated by four aminoglycoside-modifying enzymes : a 3'-phosphotransferase transferred from two strains , a 2 '' '' -phosphotransferase and a 6'-acetyltransferase transferred from all three strains , and a streptomycin adenylyltransferase transferred from two... | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
30,
44
]
} | {
"id": "C0038425",
"name": "streptomyci",
"pos": [
267,
278
]
} |
the isotype of the antibody raised in the sera of immunized volunteers was primarily igg , thus confirming the potential utility of vaccination against group b streptococci using polysaccharide vaccines to induce antibodies which will cross the human placenta . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
4,
11
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
213,
223
]
} |
once-daily vs. continuous aminoglycoside dosing : efficacy and toxicity in animal and clinical studies of gentamicin , netilmicin , and tobramycin . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
26,
40
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
106,
116
]
} |
the toxicology studies indicated that the maximal tolerated dose of free amphotericin b was 0.8 mg/kg of body weight and the 50 % lethal dose ( ld50 ) was reached at 1.2 mg/kg , while neither the maximal tolerated dose nor the ld50 for the liposomal amphotericin b was reached at a dose of 12 mg/kg . | NA | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
73,
87
]
} | {
"id": "C1145701",
"name": "liposomal amphotericin b",
"pos": [
240,
264
]
} |
when added as third-party cells to cultures containing allogeneic responders and normal fibroblast stimulators , the tumor fibroblasts inhibited the generation of ctl as well as the production of ifn-gamma . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
26,
31
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
123,
134
]
} |
the profiles of intracellular viral proteins , as visualized by radioimmunoprecipitation and electrophoresis , were not different in control or ifn-treated cells and the yield of intracellular protein p27 stayed unchanged or was slightly increased . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
30,
44
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
193,
200
]
} |
these findings identify and map a single genetic locus of human dna , c-abl , representing the complete v-abl homologue , and demonstrate the existence of additional human dna sequences corresponding to more limited , subgenomic regions of v-abl . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
24,
25
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
172,
175
]
} |
however , because of high levels of epitestosterone ( 17 alpha-hydroxyandrost-4-en-3-one ) in the follicular fluid , radioimmunoassay overestimates the true concentrations of testosterone . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
36,
51
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
175,
187
]
} |
the sequence of binding potency is identical compared to that of parent steroids and was found to be in the following order : desoxymethasone greater than dexamethasone greater than corticosterone greater than cortisol greater than progesterone greater than 17-hydroxyprogesterone . | NA | {
"id": "C0011707",
"name": "desoxymethasone",
"pos": [
126,
141
]
} | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
155,
168
]
} |
the sequence of binding potency is identical compared to that of parent steroids and was found to be in the following order : desoxymethasone greater than dexamethasone greater than corticosterone greater than cortisol greater than progesterone greater than 17-hydroxyprogesterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
232,
244
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
258,
280
]
} |
human red cell permeability to the homologous series of methanol , ethanol , n-propanol , n-butanol , and n-hexanol was determined in tracer efflux experiments by the continuous flow tube method , whose time resolution is 2-3 ms . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
56,
64
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
67,
74
]
} |
only cells grown in the presence of those cations which failed to prevent h1 induction were resistant to the cationic antibiotics , polymyxin b and gentamicin , and to chelators of divalent cations . | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
109,
117
]
} | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
181,
197
]
} |
these results support the hypothesis that protein h1 acts to replace divalent cations at a critical outer membrane site attacked by cationic antibiotics and chelators of divalent cations , and suggest that only a small proportion of the total divalent cation-binding sites in the outer membrane are susceptible to attack... | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
132,
140
]
} | {
"id": "C0007448",
"name": "divalent cation",
"pos": [
243,
258
]
} |
mutant strains were isolated , which were highly sensitive to streptomycin group aminoglycosides , had no measurable phosphotransferase activity and were unable to form detectable amounts of hydroxystreptomycin . | NA | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
62,
74
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
81,
96
]
} |
under optimal conditions , radioactive precursors are incorporated both into viral replicative form double-stranded dna and into progeny viral dna ( vdna ) during pulses as short as 30 s . | NA | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
100,
119
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
137,
146
]
} |
other sindbis e1-specific monoclonal antibodies ( 30.11 and 30.12 ) precipitate only e1 , even from lysates containing only non-ionic detergent , and their presence in such a lysate prevents precipitation of pe2 by antibody 30.2 . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
26,
47
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
215,
223
]
} |
immunoprecipitates from infected cv-1 cells labelled with [ 35s ] methionine contained three major virus-specific proteins : the nucleocapsid protein n and proteins of 36000 and 24000 molecular weight ( designated fn1 and fn2 ) . | NA | {
"id": "C0042736",
"name": "virus",
"pos": [
99,
104
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
156,
164
]
} |
the mutants were shown to be defective in the dna-binding protein gene by mapping the mutants to the area of the genome known to code for the protein , and by demonstrating alterations in the major dna-binding protein induced in mutant-infected cells . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
58,
65
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
198,
217
]
} |
dibutyryl cyclic amp and 8-benzylthio cyclic amp mimicked the effect of 5-ht on e1 but had no effect on e2 . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
0,
20
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
38,
48
]
} |
because many ca++-dependent events are blocked or reduced by enkephalin in other neuronal systems , we tested the effect of met-enkephalin on the ca++ spikes of rohon-beard cells . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
61,
71
]
} | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
124,
138
]
} |
purine synthesis and reutilization were measured as the rates of incorporation of [ u-14c ] glycine and [ g-3h ] hypoxanthine , respectively , into the adenine and guanine pools of freshly isolated hepatocytes after a 3-hour incubation in folate-free , as well as folate- and/or thymidine-supplemented culture media . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
0,
6
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
152,
159
]
} |
purine reutilization , purine pool sizes , and the adenine : guanine ratios were lower in hepatocytes from deficient compared with control rats . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
0,
6
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
51,
58
]
} |
animals infused with maltose excreted 15 % of the infused disaccharide over the 5-day infusion period . | NA | {
"id": "C0024658",
"name": "maltose",
"pos": [
21,
28
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
58,
70
]
} |
urinary excretion of beta 2-microglobulin , albumin , transferrin , and igg was significantly increased in patients , as compared with controls , whereas serum concentrations of these proteins were generally normal . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
44,
51
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
184,
192
]
} |
in 15 children with hb ee , there was a delayed fall in fetal hemoglobin , which can cause diagnostic difficulties in infants . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
20,
22
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
121,
122
]
} |
structure re-assignment of a metabolite of ampicillin and amoxycillin and epimerization of their penicilloic acids . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
43,
53
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
58,
69
]
} |
products formed in-vitro from ampicillin and amoxycillin penicilloates have been examined by high-performance liquid chromatography , ultraviolet and nuclear magnetic resonance spectroscopy and thiol group determination and were found to be the 5s epimers of the penicilloic acids . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
30,
40
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
45,
56
]
} |
a second group , consisting of buprenorphine , nalbuphine and l-pentazocine , produced only a naloxone-sensitive increase in body temperature , whereas the group comprising ethylketazocine , ketazocine , l-cyclazocine and normeperidine caused only a decrease . | NA | {
"id": "C0079314",
"name": "ethylketazocine",
"pos": [
173,
188
]
} | {
"id": "C0010526",
"name": "cyclazocine",
"pos": [
206,
217
]
} |
blockade of angiotensin ii with saralasin ( 10 micrograms/min ) further decreased blood pressure of the prazosin-treated rats by 22 +/- 4 mm hg ( p less than .001 ) . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
12,
26
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
32,
41
]
} |
binding was stereoselective and agonists competed with the rank order of potency isoproterenol greater than epinephrine greater than norepinephrine , signifying a preponderance of beta-2 receptors . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
108,
119
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
133,
147
]
} |
these factors contribute to subsequent trismus , muscle spasm and pain , and long-term pathologic remodeling of the joint . | NA | {
"id": "C0041105",
"name": "trismus",
"pos": [
39,
46
]
} | {
"id": "C0037763",
"name": "muscle",
"pos": [
49,
55
]
} |
after 3 h preincubation with 0.75 mmol nomifensine hydrogen maleate/l , 2/181 and 0/256 eggs were penetrated in two separate series of experiments . | NA | {
"id": "C0041119",
"name": "3 h",
"pos": [
6,
9
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
51,
59
]
} |
a creatine kinase assay based on estimation of creatine liberated from creatine phosphate was accurate and reproducible for use with seminal or prostatic fluid , after allowance was made for acid phosphatase interference . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
2,
10
]
} | {
"id": "C0031634",
"name": "creatine",
"pos": [
71,
79
]
} |
glucan activated both the classical pathway of normal human sera and the alternate pathways in c2hu-deficient sera in vitro releasing anaphylatoxins such as c3a . | NA | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
134,
148
]
} | {
"id": "C0009510",
"name": "c3a",
"pos": [
157,
160
]
} |
distribution of gold in rat blood after intravenous administration of auranofin , gold sodium thiomalate and aurothioglucose to rats . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
16,
20
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
70,
79
]
} |
distribution of gold in rat blood after intravenous administration of auranofin , gold sodium thiomalate and aurothioglucose to rats . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
16,
20
]
} | {
"id": "C0018034",
"name": "gold sodium thiomalate",
"pos": [
82,
104
]
} |
distribution of gold in rat blood after intravenous administration of auranofin , gold sodium thiomalate and aurothioglucose to rats . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
16,
20
]
} | {
"id": "C0018033",
"name": "aurothioglucose",
"pos": [
109,
124
]
} |
distribution of gold in rat blood after intravenous administration of auranofin , gold sodium thiomalate and aurothioglucose to rats . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
70,
79
]
} | {
"id": "C0018033",
"name": "aurothioglucose",
"pos": [
109,
124
]
} |
serum , blood and cell-associated gold were determined at various time periods after intravenous administration of 1 mg au/kg of auranofin ( af ) , gold sodium thiomalate ( gstm ) and aurothioglucose ( gtg ) . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
34,
38
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
129,
138
]
} |
serum , blood and cell-associated gold were determined at various time periods after intravenous administration of 1 mg au/kg of auranofin ( af ) , gold sodium thiomalate ( gstm ) and aurothioglucose ( gtg ) . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
34,
38
]
} | {
"id": "C0018034",
"name": "gold sodium",
"pos": [
148,
159
]
} |
serum , blood and cell-associated gold were determined at various time periods after intravenous administration of 1 mg au/kg of auranofin ( af ) , gold sodium thiomalate ( gstm ) and aurothioglucose ( gtg ) . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
34,
38
]
} | {
"id": "C0018033",
"name": "aurothioglucose",
"pos": [
184,
199
]
} |
serum , blood and cell-associated gold were determined at various time periods after intravenous administration of 1 mg au/kg of auranofin ( af ) , gold sodium thiomalate ( gstm ) and aurothioglucose ( gtg ) . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
129,
138
]
} | {
"id": "C0018033",
"name": "aurothioglucose",
"pos": [
184,
199
]
} |
in contrast , gstm and gtg serum gold values were generally higher than blood values since cell-associated gold rarely occurred . | NA | {
"id": "C0018034",
"name": "gstm",
"pos": [
14,
18
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
107,
111
]
} |
these observations suggest that , in contrast to gstm and gtg , intravenous administration of af results in a dynamic equilibrium of gold between the cellular and serum compartments of blood . | NA | {
"id": "C0018034",
"name": "gstm",
"pos": [
49,
53
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
133,
137
]
} |
these observations suggest that , in contrast to gstm and gtg , intravenous administration of af results in a dynamic equilibrium of gold between the cellular and serum compartments of blood . | NA | {
"id": "C0004320",
"name": "af",
"pos": [
94,
96
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
133,
137
]
} |
immune complexes in serum were detected in 30 to 50 % of patients , and antibodies to the glycolipid ga1 were found in 91 % of patients with neurologic involvement . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
0,
16
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
72,
82
]
} |
compared to doxorubicin , the prodrug showed about a 7-fold improved selective cytotoxicity against chicken embryo fibroblasts transformed with the rous sarcoma virus ( which produce high levels of plasminogen activator ) compared to normal cells ( which produce low levels of plasminogen activator ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
115,
126
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
234,
246
]
} |
these isomers are active cytostatic agents closely related to an active metabolite of the antitumor drug isophosphamide , an analogue of cyclophosphamide . | NA | {
"id": "C0020823",
"name": "isophosphamide",
"pos": [
105,
119
]
} | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
137,
153
]
} |
kinetics results and principally the absence of linearity between l/v ( lactate ) versus l/na+ show that the l-lactate transport mechanism fit the properties of an ordered process with two na+ ions cotransported with one l-lactate anion . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
193,
197
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
231,
236
]
} |
( 4 ) ribonuclease degradation of similarly labeled material produced an unlabeled dna-containing polynucleotide fraction and 32p-labeled ribo-oligonucleotides ; | NA | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
98,
112
]
} | {
"id": "C0028953",
"name": "oligonucleotides",
"pos": [
143,
159
]
} |
unlike the 44,000 mr protein , production of a 67,000 mr protein ( carboxy-terminal 483 amino acid residues ) by one dna-construct is probably directed by a t-a-t-a-a-a-t-a sequence in the vector dna . | NA | {
"id": "C0012931",
"name": "dna-construct",
"pos": [
117,
130
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
196,
199
]
} |
at temperatures below 45 degrees c , erf forms stable , discrete complexes with single-stranded dna and supercoiled dna , but not with relaxed double-stranded dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
80,
99
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
143,
162
]
} |
the backbones of a-dna and b-dna structures do not occur in any of the viruses , and unusual dna structures are indicated for all six viruses . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
19,
22
]
} | {
"id": "C0919262",
"name": "b-dna",
"pos": [
27,
32
]
} |
in the heart , protein kinases that are activated by ca2+ include phosphorylase kinase , myosin light chain kinase , phospholamban kinase [ review in 4 ] , and the kinases responsible for phosphorylation of endogenous proteins in the membrane [ 11 ] and soluble [ 6 ] fractions of the cell . | NA | {
"id": "C0033640",
"name": "protein kinases",
"pos": [
15,
30
]
} | {
"id": "C0031713",
"name": "phosphorylase kinase",
"pos": [
66,
86
]
} |
a selective increase of gaba , but not of gly-induced responses was seen when either low currents ( 5-10 na ) of flu or glut driving currents were used to study the neuronal responses of the inhibitory amino acids upon steady neuronal firing . | NA | {
"id": "C0017890",
"name": "gly",
"pos": [
42,
45
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
202,
213
]
} |
sixteen pregnancies in 15 women at high genetic risk for having fetuses with skeletal dysplasias were examined by use of ultrasonography during the second trimester . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
8,
19
]
} | {
"id": "C0032980",
"name": "second",
"pos": [
148,
154
]
} |
ce cell monolayers were found to contain approximately 2 % of fc receptor-bearing cells among the fibroblast-like cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
82,
87
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
98,
108
]
} |
dna and rna filter transfer hybridization analysis substantiated the conclusions that those cell lines capable of complementing viral host range mutants contained the appropriate viral dna sequences and cytoplasmic polyadenylated rna species . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
0,
3
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
179,
188
]
} |
we have used , therefore , bovine papillomavirus type 1-transformed hamster embryo fibroblasts containing 200 to 250 episomal genome equivalents per cell as a source of viral chromatin . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
83,
94
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
149,
153
]
} |
at the restrictive temperature , h5ts125 extracts , containing a thermolabile 72-kilodalton dna-binding protein , enable the formation of an initiation complex between the 82-kilodalton terminal protein precursor ( ptp ) and dctp , but further elongation of this complex is inhibited . | NA | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
92,
111
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
195,
202
]
} |
the results suggest that the h5ts36/h5ts149 gene product is required for initiation of adenovirus type 5 dna replication and that the 72-kilodalton dna-binding protein functions early in elongation . | NA | {
"id": "C0033684",
"name": "gene product",
"pos": [
44,
56
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
148,
167
]
} |
measurements of single-stranded fd dna molecules saturated with protein and spread for electron microscopy by using both the aqueous and formamide spreading techniques indicated that the dna is held in an extended configuration with a base spacing of approximately 0.13 nm per base . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
16,
31
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
187,
190
]
} |
thus , the 34 , 26 , and 42k polypeptides coded for by mrnas 2 , 3 , and 4 , respectively , were identified as the respiratory syncytial virus phosphoprotein ( 34k ) , matrix protein ( 26k ) , and nucleocapsid protein ( 42k ) , respectively . | NA | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
143,
157
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
210,
217
]
} |
intravenous bolus administration of magnesium ( mg ) sulfate , followed by intramuscular mg repletion , abolished the digitalis-toxic arrhythmia . | NA | {
"id": "C0024480",
"name": "magnesium",
"pos": [
36,
45
]
} | {
"id": "C0024467",
"name": "mg",
"pos": [
89,
91
]
} |
chemically lmox is especially unique with a sulfur atom replacing the oxygen atom in the 1 position of the conventional cephalosporin nucleus , and in addition , this antibiotic has a cephamycin-like structure . | NA | {
"id": "C3536856",
"name": "cephalosporin",
"pos": [
120,
133
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
184,
194
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and c... | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
50,
60
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
79,
91
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and c... | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
50,
60
]
} | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
94,
105
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and c... | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
149,
159
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
162,
173
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and c... | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
176,
185
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
214,
222
]
} |
clinical efficacy was evaluated based on the effect of treatment on bacteriuria and pyuria according to the criteria set by the uti committee , japan . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
68,
79
]
} | {
"id": "C0042029",
"name": "uti",
"pos": [
128,
131
]
} |
clinical efficacy was evaluated based on the effect of treatment on bacteriuria and pyuria according to the criteria set by the uti committee , japan . | NA | {
"id": "C0034359",
"name": "pyuria",
"pos": [
84,
90
]
} | {
"id": "C0042029",
"name": "uti",
"pos": [
128,
131
]
} |
sisomicin , dibekacin , amikacin , netilmicin , tobramycin ribostamycin and kanamycin did not inhibit the strain at the concentrations less than 25 mcg/ml . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
0,
9
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
35,
45
]
} |
sisomicin , dibekacin , amikacin , netilmicin , tobramycin ribostamycin and kanamycin did not inhibit the strain at the concentrations less than 25 mcg/ml . | NA | {
"id": "C0012024",
"name": "dibekacin",
"pos": [
12,
21
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
76,
85
]
} |
sisomicin , dibekacin , amikacin , netilmicin , tobramycin ribostamycin and kanamycin did not inhibit the strain at the concentrations less than 25 mcg/ml . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
24,
32
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
76,
85
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.