text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
[ studies on the combination action of sisomicin , gentamicin and piperacillin , cefmetazole against pseudomonas aeruginosa and serratia marcescens ] . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
39,
48
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
51,
61
]
} |
the combined actions of sisomicin ( siso ) , gentamicin ( gm ) and piperacillin ( pipc ) , cefmetazole ( cmz ) against pseudomonas aeruginosa e-2 and serratia marcescens t-55 were studied . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
24,
33
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
45,
55
]
} |
the combinations of siso-pipc , siso-cmz , gm-pipc and gm-cmz using the checker board dilution method on p. aeruginosa e-2 and s. marcescens t-55 were found to have a synergistic effect and the minimum fic index values were 0.38 in all combinations . | NA | {
"id": "C0037209",
"name": "siso",
"pos": [
20,
24
]
} | {
"id": "C0017436",
"name": "gm",
"pos": [
55,
57
]
} |
a synergistic effect of the combinations of siso-pipc , siso-cmz , gm-pipc and gm-cmz was observed in the protective effect on experimental p. aeruginosa e-2 and s. marcescens t-55 infections in mice . | NA | {
"id": "C0037209",
"name": "siso",
"pos": [
44,
48
]
} | {
"id": "C0017436",
"name": "gm",
"pos": [
79,
81
]
} |
the effects of retinol ( vitamin a alcohol ) , retinoic acid ( vitamin a acid ) , and beta-carotene ( pro-vitamin a ) on human interferon ( huifn ) action were examined in vitro . | NA | {
"id": "C0040845",
"name": "vitamin a acid",
"pos": [
63,
77
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
106,
115
]
} |
two types of cells were identified in culture , macrophages , and cells which were tentatively identified as fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
13,
18
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
109,
120
]
} |
epitrochlearis muscles obtained from normal male sprague-dawley rats used as controls ( c ) and rats with reduced renal mass ( nx ) were incubated for 1 hr in krebs-ringer buffer containing 5 mm glucose with or without insulin , 25-hydroxycholecalciferol [ 25 ( oh ) d3 ] or 1,25 dihydroxycholecalciferol [ 1,25 ( oh ) 2... | NA | {
"id": "C0006657",
"name": "25-hydroxycholecalciferol",
"pos": [
229,
254
]
} | {
"id": "C2713074",
"name": "25 ( oh ) d3",
"pos": [
257,
269
]
} |
the drops were tested with the following forms of glaucoma : glaucoma associated with alpha-kia , neovascular glaucoma , exfoliative glaucoma , pigmentary glaucoma , juvenile glaucoma . | NA | {
"id": "C0017609",
"name": "neovascular glaucoma",
"pos": [
98,
118
]
} | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
175,
183
]
} |
we can now confirm this theory by laser nephelometric measurements and demonstrate the oligomannosyl specificity of this lectin-like protein gluten . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
121,
127
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
133,
140
]
} |
concomitant with reduction of core volume , redundant surface lipids and proteins move along a surface pathway and either form high density ( hdl ) lipoprotein precursors , or become associated with existing hdl particles . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
62,
68
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
148,
159
]
} |
the widespread use of different methods for the determination of hdl-cholesterol ( in europe : sodium phosphotungstic acid/mgcl2 ) in connection with enzymatic procedures ( in the usa : heparin/mncl2 followed by the liebermann-burchard method ) but common reference values makes it necessary to evaluate not only accurac... | NA | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
65,
80
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
405,
416
]
} |
race , nutrition , treatment , exercise , and hypertension may further influence the prevalence of angiopathy in diabetics of same sex , age , and duration of the disease . | NA | {
"id": "C0020538",
"name": "hypertension",
"pos": [
46,
58
]
} | {
"id": "C0042373",
"name": "angiopathy",
"pos": [
99,
109
]
} |
rats were exposed to 7-day hypokinesia and the effect of an enkephalin analog on the secretion of pepsin , amylase , the shape of the glycemic curve and the secretion of gastrointestinal hormones , gastrin and insulin , was investigated . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
170,
195
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
198,
205
]
} |
it is inferred that an increase in the complement content reflects an adaptive reaction to head-down tilt and a decrease in heterophil antibodies indicates an inhibition of antibody-forming cells ( b-lymphocytes ) . | NA | {
"id": "C0003248",
"name": "heterophil antibodies",
"pos": [
124,
145
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
173,
181
]
} |
the effect of altitude chamber hypoxia of different intensity and duration on epinephrine and norepinephrine excretion was investigated . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
78,
89
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
94,
108
]
} |
we have studied the rate and character with which testosterone ( t ) and 5 alpha-dihydrotestosterone ( dht ) dissociate from the androgen receptor both within intact cultured genital skin fibroblasts of a subject with 5 alpha-reductase deficiency and after the androgen-receptor complexes have been extracted from the ce... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
188,
199
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
318,
323
]
} |
k+ repletion for 48 h of rats previously kept on a low k+ diet for 2 weeks specifically increased the conversion of corticosterone into aldosterone and 18-hydroxycorticosterone by incubated capsular fractions of rat adrenal tissue . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
116,
130
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
152,
176
]
} |
overall , contribution of agp to the total plasma binding of prednisolone is less than 3 % when considered in the competitive protein binding system with transcortin and albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
126,
133
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
170,
177
]
} |
to examine the antihypertensive effects of captopril , when used in combination with diuretics , an oral dose of the agent ( 30 mg/kg ) was given to spontaneously hypertensive rats pretreated for 1 week with trichlormethiazide ( tctz ) , hydrochlorothiazide ( hctz ) , furosemide , or water . | NA | {
"id": "C0040899",
"name": "trichlormethiazide",
"pos": [
208,
226
]
} | {
"id": "C0020261",
"name": "hydrochlorothiazide",
"pos": [
238,
257
]
} |
the degree of potentiation was in the following order : furosemide greater than or equal to hctz greater than tctz . | NA | {
"id": "C0020261",
"name": "hctz",
"pos": [
92,
96
]
} | {
"id": "C0040899",
"name": "tctz",
"pos": [
110,
114
]
} |
plasma renin concentration ( prc ) prior to the administration of captopril was highest in the furosemide group , followed by the hctz , tctz , and control groups , in this order . | NA | {
"id": "C0020261",
"name": "hctz",
"pos": [
130,
134
]
} | {
"id": "C0040899",
"name": "tctz",
"pos": [
137,
141
]
} |
effects of felodipine , a new dihydropyridine vasodilator , on regional myocardial blood flow during acute coronary occlusion in the pig . | NA | {
"id": "C0015772",
"name": "felodipine",
"pos": [
11,
21
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
30,
45
]
} |
we studied the effects of felodipine [ 4- ( 2,3-dichlorophenyl ) -1,4-dihydropyridine-2,6-dimethyl 3,5-dicarboxylic 3-ethylester and 5-methylester ] on the coronary vascular bed of pig hearts with an ischemic region in the left ventricle following ligation of the left anterior descending coronary artery . | NA | {
"id": "C0015772",
"name": "felodipine",
"pos": [
26,
36
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
70,
85
]
} |
a micro high-performance liquid chromatography ( mhplc ) -precolumn dansylation procedure for determination of norepinephrine ( ne ) , epinephrine ( e ) , and dopamine ( do ) in various kinds of rat tissue has been developed . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
111,
125
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
135,
146
]
} |
pindolol , a well-tolerated noncardioselective beta-adrenergic blocking drug , effectively reduced blood pressure in patients with mild to moderate hypertension without causing orthostatic hypotension . | NA | {
"id": "C0020649",
"name": "reduced blood pressure",
"pos": [
91,
113
]
} | {
"id": "C0020651",
"name": "orthostatic hypotension",
"pos": [
177,
200
]
} |
the development of an atherosclerotic lesion is characterised by a proliferation of arterial smooth muscle cells and an accumulation of cholesterol , cholesteryl esters and connective tissue . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
136,
147
]
} | {
"id": "C0008387",
"name": "cholesteryl",
"pos": [
150,
161
]
} |
the content of cholesterol or collagen relative to protein in the aorta or endarterectomy specimens did not correlate with serum total cholesterol , triglyceride , or high-density-lipoprotein cholesterol , nor were there any significant differences between samples from normotensive and hypertensive patients . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
15,
26
]
} | {
"id": "C0023822",
"name": "high-density-lipoprotein cholesterol",
"pos": [
167,
203
]
} |
there was a remarkable coincidence between adenocarcinomas and adenocystic carcinomas on the one hand , and patients who were occupationally exposed to wood dust on the other ; | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
43,
58
]
} | {
"id": "C0010606",
"name": "adenocystic carcinomas",
"pos": [
63,
85
]
} |
the share of the woodworkers in the total number of occupationally active patients in our area of examination was 2.14 % , whereas 17.2 % of the patients with adenocarcinoma and adenocystic carcinoma had been occupationally exposed to wood dust . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
159,
173
]
} | {
"id": "C0010606",
"name": "adenocystic carcinoma",
"pos": [
178,
199
]
} |
the statistical examination of the postulated connection between exposure to wood dust and the occurrence of malignant tumours of the histological type of the adenocarcinoma and adenocystic carcinoma , showed a highly significant correlation . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
159,
173
]
} | {
"id": "C0010606",
"name": "adenocystic carcinoma",
"pos": [
178,
199
]
} |
the rare association of tonsillitis and pharyngitis with non-rheumatic , non-diphtheritic , non-fatal myocarditis was recognized and reported in the pre and early antibiotic era . | NA | {
"id": "C0040425",
"name": "tonsillitis",
"pos": [
24,
35
]
} | {
"id": "C0031350",
"name": "pharyngitis",
"pos": [
40,
51
]
} |
the ptdins 'breakdown ' studied previously was probably utilization of ptdins for resynthesis of polyphosphoinositides to replace the degraded ptdins4,5p2 . | NA | {
"id": "C0031621",
"name": "ptdins",
"pos": [
4,
10
]
} | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
97,
118
]
} |
the binding of 3h-dihydromorphine and 3h-naloxone ( mu receptors ) , 3h-d-ala2-d-leu5-enkephalin ( delta receptors ) , and 3h-ethylketocyclazocine ( kappa receptors ) to opiate receptors in the mouse brain homogenate was also unaffected by both the peptides over a large concentration range . | NA | {
"id": "C0066908",
"name": "mu receptors",
"pos": [
52,
64
]
} | {
"id": "C0034801",
"name": "opiate",
"pos": [
170,
176
]
} |
the binding of 3h-dihydromorphine and 3h-naloxone ( mu receptors ) , 3h-d-ala2-d-leu5-enkephalin ( delta receptors ) , and 3h-ethylketocyclazocine ( kappa receptors ) to opiate receptors in the mouse brain homogenate was also unaffected by both the peptides over a large concentration range . | NA | {
"id": "C0140057",
"name": "delta receptors",
"pos": [
99,
114
]
} | {
"id": "C0034801",
"name": "opiate",
"pos": [
170,
176
]
} |
the binding of 3h-dihydromorphine and 3h-naloxone ( mu receptors ) , 3h-d-ala2-d-leu5-enkephalin ( delta receptors ) , and 3h-ethylketocyclazocine ( kappa receptors ) to opiate receptors in the mouse brain homogenate was also unaffected by both the peptides over a large concentration range . | NA | {
"id": "C0064239",
"name": "kappa receptors",
"pos": [
149,
164
]
} | {
"id": "C0034801",
"name": "opiate",
"pos": [
170,
176
]
} |
long-term organ cultures of mouse anterior pituitaries provides a system for generating an enriched starting material for the purification of prolactin and growth hormone . | NA | {
"id": "C0032016",
"name": "anterior pituitaries",
"pos": [
34,
54
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
156,
170
]
} |
culturing 1 anterior pituitary per ml in serum-free medium for 12 days resulted in a total yield of 40.9 micrograms and 6.6 micrograms of prolactin and growth hormone , respectively . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
12,
30
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
152,
166
]
} |
present evidence strongly implicates monoamines and the endogenous opioid peptides as well as other neuropeptides as playing a role in the central regulation of stress-induced eating . | NA | {
"id": "C0205753",
"name": "endogenous opioid",
"pos": [
56,
73
]
} | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
100,
113
]
} |
these doses of eedq also reduce binding of 3h-flupentixol to d-1 and 3h-dopamine to d-3 type dopaminergic binding sites , putative dopamine receptors with no known behavioral correlates . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
72,
80
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
93,
105
]
} |
elevated blood ammonia has also been linked to a surprising variety of functional and metabolic neurological disturbances other than exercise and fatigue , including the development of hepatic coma , convulsions from ammonia toxicity precipitated by high-pressure oxygen breathing , epileptic seizures , and decreased ne... | NA | {
"id": "C0036572",
"name": "convulsions",
"pos": [
200,
211
]
} | {
"id": "C0014544",
"name": "epileptic seizures",
"pos": [
283,
301
]
} |
the cutaneous extravascular necrotizing granuloma ( churg-strauss granuloma ) and systemic disease : a review of 27 cases . | NA | {
"id": "C0008728",
"name": "churg-strauss",
"pos": [
52,
65
]
} | {
"id": "C0018188",
"name": "granuloma",
"pos": [
66,
75
]
} |
hla antigens ( a , b , c and dr loci ) , serum islet cell antibodies , thyrogastric antibodies , and insulin antibodies were studied in 77 families ( 25 simplex , 42 multiplex , and 10 multigenerational ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
58,
68
]
} | {
"id": "C0021644",
"name": "insulin antibodies",
"pos": [
101,
119
]
} |
insulin pharmacokinetics following continuous infusion and bolus injection of regular porcine and human insulin in healthy man . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
98,
111
]
} |
to determine the pharmacokinetics of insulin administered by intravenous ( iv ) and subcutaneous ( sc ) pump treatment as well as by the conventional subcutaneous route , six insulin preparations of either porcine or human amino acid sequence were investigated intraindividually following iv or sc insulin infusion at tw... | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
37,
44
]
} | {
"id": "C0724601",
"name": "insulin preparations",
"pos": [
175,
195
]
} |
retinyl esters have been thought to be carried solely by lipoproteins of intestinal origin ( chylomicrons and their catabolic derivatives ) . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
57,
69
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
93,
105
]
} |
the spectra and activities of isozymes of hexokinase and alcohol dehydrogenase ( enzymes that catalyse glucose and ethanol assimilation ) , glucose-6-phosphate dehydrogenase ( the key enzyme of the pentose phosphate shunt ) and malate dehydrogenase ( an enzyme of the tricarboxylic acid cycle ) were comparatively studie... | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
30,
38
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
81,
88
]
} |
the object of this work was to study the ability of candida yeasts to accumulate biomass , lipids and wax in the course of their cultivation in a medium containing different concentrations of n-hexadecane . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
91,
97
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
102,
105
]
} |
as a hypothesis , it is suggested that this mi pandemic , still raging today , was caused by a change in food processing that occurred after 1920 , when the new oil seed industry introduced into our food three greatly harmful lipid substances . | NA | {
"id": "C0028908",
"name": "oil",
"pos": [
161,
164
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
226,
231
]
} |
gentamicin absorption is mediated by a phospholipid carrier with specificity for polyamines and other aminoglycosides . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
0,
10
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
102,
117
]
} |
renal choline kinase activity fell by 20 % , from 47.3 +/- sem 2.2 to 37.8 +/- 1.4 pmol 14c-choline incorporated into phosphorylcholine/min/mg protein in the potassium-loaded rats ( p less than 0.005 ) . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
6,
13
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
118,
135
]
} |
based on these characteristics and on the comparative study of tryptic hydrolyzates of the plant protein and e. coli l7/l12 , the protein so obtained is found to be homologous to the l7/l12 of the procaryotic ribosomes . | NA | {
"id": "C0032089",
"name": "plant protein",
"pos": [
91,
104
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
130,
137
]
} |
reconstitution of membrane-bound enzymes and transport proteins with the artificial phospholipid bilayer ( liposomes ) is one of the most useful techniques to study the functional aspects of these proteins . | NA | {
"id": "C0007292",
"name": "transport proteins",
"pos": [
45,
63
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
197,
205
]
} |
two herpes simplex virus proteins , the major capsid protein and the major dna binding protein , are specifically localized to the nucleus of infected cells . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
25,
33
]
} | {
"id": "C0012940",
"name": "dna",
"pos": [
75,
78
]
} |
we have demonstrated that the dna binding protein and the capsid protein exchange from the cytoplasmic framework to the nuclear framework , suggesting the direct movement of the proteins from one structure to the other . | NA | {
"id": "C0012940",
"name": "dna binding protein",
"pos": [
30,
49
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
178,
186
]
} |
here the n-terminal sequence of the vh regions from 14 cri+ and 8 cri- antibodies as well as the vl regions from 11 cri+ and 8 cri- monoclonal antibodies are compared . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
71,
81
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
132,
153
]
} |
about 50 % of the strains of cultured fibroblasts from patients with familial polyposis coli ( fpc ) exhibited increased susceptibility to cytotoxicity of 4-nitroquinoline-1-oxide ( 4nqo ) compared with cells from normal individuals . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
38,
49
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
203,
208
]
} |
the extent of single-strand scission of dna in the 4nqo-sensitive fpc cells was greater than in normal cells , and the amount of [ 14c ] 4nqo bound to dna in the fpc cells was twice as high as in normal cells . | NA | {
"id": "C0012935",
"name": "single-strand",
"pos": [
14,
27
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
151,
154
]
} |
to develop a model that would forecast neurologic recovery after out-of-hospital cardiac arrest , we reviewed charts on 389 consecutive patients who were not awake on admission to the hospital after resuscitation from asystole or ventricular fibrillation . | NA | {
"id": "C2936490",
"name": "out-of-hospital",
"pos": [
65,
80
]
} | {
"id": "C0018790",
"name": "asystole",
"pos": [
218,
226
]
} |
leukotriene d4 ( ltd4 ) , a component of slow reacting substance of anaphylaxis ( srs-a ) 1 , produces marked hypotension in laboratory animals2,3 , implicating it as a potential mediator of anaphylactic shock . | NA | {
"id": "C0023544",
"name": "leukotriene d4",
"pos": [
0,
14
]
} | {
"id": "C0038091",
"name": "of slow reacting substance",
"pos": [
38,
64
]
} |
already a trace of oxygen mediates the one-electron transfer from 3,4-benzopyrene ( benzo ( a ) pyrene , bp ) to hydrogen peroxide or to tert . butyl hydroperoxide ( rooh ) , leading in this way to generation of highly reactive ho x , ho2 x or ro x and ro2 x radicals in nonpolar solvents at biological temperatures . | NA | {
"id": "C0005082",
"name": "benzopyrene",
"pos": [
70,
81
]
} | {
"id": "C0005052",
"name": "benzo ( a ) pyrene",
"pos": [
84,
102
]
} |
in experiments reported elsewhere the present authors have shown that nephrectomy resulted in a regionally selective increase in levels of brain angiotensinogen , the putative prohormone of any cns angiotensin peptides . | NA | {
"id": "C0003017",
"name": "angiotensinogen",
"pos": [
145,
160
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
198,
209
]
} |
angiotensin ii-induced drinking was markedly potentiated following nephrectomy , indicative of possible up-regulation of angiotensin receptors in selected regions of the rat brain . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
0,
14
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
121,
132
]
} |
thpo was also effective in preventing seizures induced in epileptic chicks by intermittent photic stimulation . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
38,
46
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
58,
67
]
} |
and ( 3 ) n-methyl-beta-hydroxy-phenylethylamine ( nmpea ) , were tested in the upper and lower segments of the thoracic spinal cord of the cat . alpha-methylnoradrenaline , na and ad had an inhibitory action on the majority of spontaneously firing neurones . | NA | {
"id": "C0025805",
"name": "alpha-methylnoradrenaline",
"pos": [
146,
171
]
} | {
"id": "C0028351",
"name": "na",
"pos": [
174,
176
]
} |
and ( 3 ) n-methyl-beta-hydroxy-phenylethylamine ( nmpea ) , were tested in the upper and lower segments of the thoracic spinal cord of the cat . alpha-methylnoradrenaline , na and ad had an inhibitory action on the majority of spontaneously firing neurones . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
124,
126
]
} | {
"id": "C0014563",
"name": "ad",
"pos": [
185,
187
]
} |
inhibition of the activity of preganglionic neurones and neurones activated by visceral afferents induced by alpha-mna was usually equal to the effect of na , but in some neurones alpha-mna was more potent . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
116,
118
]
} | {
"id": "C0025805",
"name": "alpha-mna",
"pos": [
180,
189
]
} |
the inhibitory effect of alpha-mda was weaker and that of nmpea was much weaker than that of alpha-mna and na . | NA | {
"id": "C0025805",
"name": "alpha-mna",
"pos": [
93,
102
]
} | {
"id": "C0028351",
"name": "na",
"pos": [
107,
109
]
} |
the inhibitory effects of alpha-mna and na in the cerveau isole preparation resembled those observed in anaesthetized animals . | NA | {
"id": "C0025805",
"name": "alpha-mna",
"pos": [
26,
35
]
} | {
"id": "C0028351",
"name": "na",
"pos": [
105,
107
]
} |
the antagonism of hypothermia induced by dibutyryl cyclic gmp and acetylcholine + physostigmine , by central administration of a cholinergic muscarinic receptor antagonist , atropine , and not by a cholinergic nicotinic receptor antagonist , d-tubocurarine , suggests that cholinoceptive neurons and endogenous cyclic gm... | NA | {
"id": "C0012055",
"name": "dibutyryl",
"pos": [
41,
50
]
} | {
"id": "C0018338",
"name": "cyclic gmp",
"pos": [
311,
321
]
} |
60 training sessions . d-amphetamine generalized to cocaine with approximately equal potency ( ed50 's for cocaine and d-amphetamine were 0.07 and 0.06 mg/kg , respectively ) ; | NA | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
25,
36
]
} | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
119,
132
]
} |
following intraperitoneal administration , the selective camp phosphodiesterase ( pde ) inhibitors rolipram , ici 63 197 and ro 20-1724 were investigated in mice in comparison with imipramine for their effectiveness in two classical test models for prediction of clinical antidepressant activity : antagonism of reserpin... | NA | {
"id": "C0035179",
"name": "reserpine",
"pos": [
312,
321
]
} | {
"id": "C0724441",
"name": "lethality",
"pos": [
387,
396
]
} |
the effects of the pure narcotic antagonists , naloxone and naltrexone , and their quaternary derivatives , methylnaloxone and methylnaltrexone , were examined in reversing the catalepsy induced by morphine in rats . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
47,
55
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
133,
143
]
} |
both naloxone and naltrexone , administered subcutaneously 40 min after the injection of morphine , dose-dependently reduced the duration of the catalepsy at doses of 10-30 micrograms/kg . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
5,
13
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
18,
28
]
} |
both naloxone ( 3 and 10 mg x kg-1 ) and naltrexone ( 1-10 mg x kg-1 ) abolished the preference for a highly palatable 0.05 % sodium saccharin solution in rats that had been adapted to a 22 hr water-deprivation schedule . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
5,
13
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
41,
51
]
} |
when a less preferred saccharin solution was used ( 0.01 % ) , naltrexone exerted a similar suppressant effect on the sodium preference , whilst naloxone failed to produce significant effects on the intake of saccharin solution or water . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
63,
73
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
145,
153
]
} |
offspring of mothers treated with morphine ( 7.5 mg/kg twice daily , s.c. ) or saline during pregnancy , and infants from untreated mothers given morphine ( 5 mg/kg ) , naltrexone ( 10 mg/kg ) or saline subcutaneously on postnatal days 1-5 , were tested at days 10 , 12 and 14 for deprivation-induced milk consumption fo... | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
169,
179
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
345,
353
]
} |
naloxone had no effect on the food consumed by 10- or 12-day old offspring of mothers treated with morphine or saline , or on those age-groups that received naltrexone chronically or saline pretreatments postnatally . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
0,
8
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
157,
167
]
} |
regardless of the radiographic classification , all patients except one , who harbored a well-differentiated astrocytoma in the area of the pons , had an anaplastic astrocytoma ( n = 14 ) or a glioblastoma multiforme ( n = 6 ) . | NA | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
109,
120
]
} | {
"id": "C0017636",
"name": "glioblastoma multiforme",
"pos": [
193,
216
]
} |
high resolution computed tomographic scans , with reconstructed images of the posterior fossa , can predict the presence and location of brain stem tumors and associated cysts and probably the histological nature of the tumor . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
170,
175
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
220,
225
]
} |
csf content of homovanillic acid , a major metabolite of dopamine , increased during high-dose thip therapy , suggesting that augmentation of dopaminergic function may have contributed to the drug 's lack of efficacy . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
57,
65
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
142,
154
]
} |
no arguments in support of the co-existence of enkephalins and the neurohypophyseal hormones vasopressin and oxytocin in the same terminal were found . | NA | {
"id": "C0032017",
"name": "neurohypophyseal hormones",
"pos": [
67,
92
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
109,
117
]
} |
spinal cord tissue lactic acid levels were stepwise elevated , and adenosine triphosphate ( atp ) , phosphocreatine ( p-creatine ) , and glucose were progressively consumed by increasing durations of ischemia . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
100,
115
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
120,
128
]
} |
although these ct features are usually associated with infarcts or cysts , neoplasm was suspected because of irregularity of the margins and erosion of the adjacent inner table of the skull . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
67,
72
]
} | {
"id": "C0027651",
"name": "neoplasm",
"pos": [
75,
83
]
} |
there was no correlation between the number of miles run during the pregnancy , or in the third trimester alone , and either infant birth weight or gestational age . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
68,
77
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
90,
105
]
} |
both patients experienced shunt malfunction early in the third trimester which was apparently related to anatomic changes in the abdomen associated with pregnancy . | NA | {
"id": "C0032981",
"name": "third",
"pos": [
57,
62
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
153,
162
]
} |
the effect of two specific placental proteins , trophoblastic beta 1-glycoprotein ( tbg ) and chorionic alpha 1-microglobulin ( cag ) , on the immunological reactions was studied in vitro . | NA | {
"id": "C0032974",
"name": "placental proteins",
"pos": [
27,
45
]
} | {
"id": "C0033002",
"name": "trophoblastic beta 1-glycoprotein",
"pos": [
48,
81
]
} |
the method is simple , reproducible , inexpensive ( the polyvalent antiserum was used at 1 % in the antibody-containing gel ) and allowed quantitative determination . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
67,
76
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
100,
108
]
} |
the possible inhibitory effect of vitamin c ( sodium ascorbate ) on metastases from two transplantable murine tumors was studied . | NA | {
"id": "C0003968",
"name": "vitamin c",
"pos": [
34,
43
]
} | {
"id": "C0887557",
"name": "sodium ascorbate",
"pos": [
46,
62
]
} |
aggregate mean values for protein , albumin , vitamin a , and phosphorus were generally acceptable , but many subjects had inadequate ( though not necessarily deficient ) values for nicotinic acid ( 74 % of subjects ) , magnesium ( 60 % ) , vitamin c ( 55 % ) , carotene ( 53 % ) , riboflavin ( 41 % ) , calcium ( 35 % )... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
26,
33
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
36,
43
]
} |
in addition , multiprogrammable `` '' non-committed '' '' av sequential ( dvi , mn and ddd , m ) pacemakers were permanently implanted to treat different forms of ventricular tachyarrhythmias that included : torsade de pointes in the romano-ward syndrome and chagas ' cardiomyopathy , ventricular tachycardia which is br... | NA | {
"id": "C0040479",
"name": ": torsade de point",
"pos": [
206,
224
]
} | {
"id": "C0042514",
"name": ", ventricular tachycard",
"pos": [
283,
306
]
} |
these tests are directly applicable to studies of polysiloxane ( silicone ) and polyurethane cardiac pacing leads . | NA | {
"id": "C0037121",
"name": "polysiloxane",
"pos": [
50,
62
]
} | {
"id": "C0037114",
"name": "silicone",
"pos": [
65,
73
]
} |
electrocardiograms of 11 patients showed signs of chamber hypertrophy and t wave and st segment features of varying degree compatible with ischemia or infarction . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
139,
147
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
151,
161
]
} |
assay of amylo-1,6-glucosidase activity in cultured skin fibroblasts from the affected family revealed less than 10 per cent of control value in mutant homozygous cells whereas in cells from the parents , activity was reduced to 40-60 per cent of the control value . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
57,
68
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
180,
185
]
} |
measurements of magnesium levels in blood and urine are justified when such abnormalities occur in patients with digestive disorders , predominantly alcoholism , liver diseases or malabsorption . | NA | {
"id": "C0012242",
"name": "digestive disorders",
"pos": [
113,
132
]
} | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
162,
176
]
} |
in the presence of dietary cholesterol , serum lipids are affected by saturated and polyunsaturated fatty acids through an interaction with cholesterol . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
19,
38
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
140,
151
]
} |
the effects of dietary cholesterol observed by dutch workers are also in agreement with our prediction , when cholesterol ( egg yolk ) was added to a diet rich in polyunsaturated fatty acids , but not when added to a diet rich in saturated fatty acids . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
15,
34
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
110,
121
]
} |
the hypocholesterolemic effect of dietary vegetable proteins was studied by comparing egg-white protein and fava bean protein concentrate in one normal and seven hypercholesterolemic ( six type ii a , one ii b ) persons ; | NA | {
"id": "C0013700",
"name": "egg",
"pos": [
86,
89
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
118,
125
]
} |
to minimize lipoprotein-mediated chd risk it may be necessary to attain population mean plasma cholesterol levels of less than 200 mg/dl , a target which is probably feasible by dietary modifications directed to lipid , fiber , and energy intake . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
12,
23
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
212,
217
]
} |
data on distributions of adult rbm and bw show that it is more likely that children with a bw greater than or equal to 4.5 kg will become obese in a later stage of life than those whose bw was less than or equal to 3.2 kg . | NA | {
"id": "C0005910",
"name": "bw",
"pos": [
39,
41
]
} | {
"id": "C0005612",
"name": "bw",
"pos": [
186,
188
]
} |
these findings appear to rule out the presence of parasite protein ( s ) playing a structural role in the formation of knobs on the erythrocyte surface and question whether the antigenic determinants on the p. falciparum-infected erythrocyte are of parasite origin or whether such antigens represent newly exposed or che... | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
177,
199
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
281,
289
]
} |
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