text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
some enzymes of the bypass also feature in glycolysis ( aldolase and alcohol dehydrogenase ) , and these enzymes , with the reductases involved , are proteins known to occur in different classes or multiple isozyme forms . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
5,
12
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
207,
214
]
} |
genomic clones and cdna plasmids were isolated for the intermediate filament protein vimentin from chicken . | NA | {
"id": "C0021769",
"name": "intermediate filament",
"pos": [
55,
76
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
85,
93
]
} |
material having an absorbance peak at 254 nm , obtained from the enzyme by phenol extraction , is degraded by treatment with pancreatic rnase , t1 rnase , and alkali but is stable to dnase . | NA | {
"id": "C0035541",
"name": "pancreatic rnase",
"pos": [
125,
141
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
147,
152
]
} |
gtp , gdp , and the nonhydrolyzable analogs 5'-guanylyl imidodiphosphate ( gpp [ nh ] p ) and guanosine 5'-o- ( 2-thiodiphosphate ) ( gdp-s ) effectively decreased the binding to both receptor types . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
0,
3
]
} | {
"id": "C0018366",
"name": "gpp [ nh ] p",
"pos": [
75,
87
]
} |
similar pretreatment with gdp-s resulted in only a partial increase of binding compared to gtp or gdp , and gpp [ nh ] p was relatively ineffective . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
91,
94
]
} | {
"id": "C0018366",
"name": "gpp [ nh ] p",
"pos": [
108,
120
]
} |
the cellular location of the phosphorylated 36-kilo-dalton protein ( pp36 ) in chicken embryo fibroblasts transformed by the schmidt-ruppin strain of rsv has been investigated . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
4,
12
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
94,
105
]
} |
prostacyclin ( 1 microm ) inhibits ( i ) the formation of phosphatidic acid and lysophosphatidylinositol and ( ii ) the resynthesis of polyphosphoinositides induced by 0.03 microm paf without affecting the initial loss of ptdins ( 4,5 ) p2 . | NA | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
135,
156
]
} | {
"id": "C0031621",
"name": "ptdins",
"pos": [
222,
228
]
} |
a fsh-dependent phosphoprotein with a molecular weight of 58,000 was identified as the intermediate filament protein vimentin , based on its migration in two-dimensional gels and its peptide map . | NA | {
"id": "C0021769",
"name": "intermediate filament protein",
"pos": [
87,
116
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
117,
125
]
} |
cultured human foreskin and fetal lung fibroblasts secreted thrombospondin ( determined by enzyme-linked immunosorbent assay ) into the culture medium in a time-dependent manner ( 15.7 and 5.8 micrograms per 10 ( 6 ) cells per 24 hr , respectively ) ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
39,
50
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
217,
222
]
} |
[ 3h ] thrombospondin was isolated from [ 3h ] leucine-labeled fibroblast postculture medium and from cell layers with rabbit polyclonal or mouse monoclonal anti-thrombospondin coupled to staphylococcal protein a-sepharose . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
63,
73
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
102,
106
]
} |
we have recently proposed that the major secreted isoprotein form of human apolipoprotein a-i ( designated apo a-i2 ) is modified extracellularly to become the predominant apo a-i form seen in plasma ( designated apo a-i4 ) . | NA | {
"id": "C0085201",
"name": "apo a-i",
"pos": [
107,
114
]
} | {
"id": "C0003592",
"name": "apo a",
"pos": [
213,
218
]
} |
in the current report we demonstrate that the primary translation product of human apo a-i ( designated apo a-i2p ) has a 24-amino-acid nh2-terminal extension with a sequence of met-lys-ala-ala-val-leu-thr-leu-ala-val-leu-phe- leu-thr-gly-ser-gln-ala-arg-his-phe-trp-gln-gln . | NA | {
"id": "C0085201",
"name": "apo",
"pos": [
83,
86
]
} | {
"id": "C0003592",
"name": "apo a",
"pos": [
104,
109
]
} |
the first 18 amino acids of this nh2-terminal extension are cleaved intracellularly by the signal peptidase , resulting in the formation of apo a-i2 , which is the secreted form of apo a-i . | NA | {
"id": "C0003592",
"name": "apo a",
"pos": [
140,
145
]
} | {
"id": "C0085201",
"name": "apo a-i",
"pos": [
181,
188
]
} |
our findings indicate that apo a-i is synthesized as a prepropeptide , which undergoes intracellular and extracellular proteolysis to attain the major plasma apo a-i4 isoprotein form . | NA | {
"id": "C0085201",
"name": "apo a-i",
"pos": [
27,
34
]
} | {
"id": "C0003592",
"name": "apo a",
"pos": [
158,
163
]
} |
sulfate itself , thiosulfate , and hydroxyl , but not chloride or thiocyanate , were able to substitute for bicarbonate . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
0,
7
]
} | {
"id": "C0039950",
"name": "thiosulfate",
"pos": [
17,
28
]
} |
from the measured nmr parameters and the assumptions ( i ) that creatine kinase was at equilibrium and ( ii ) that the creatine/phosphocreatine pool was constant , it was possible to calculate the relative changes in cytoplasmic adp levels associated with these metabolic disturbances . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
64,
72
]
} | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
128,
143
]
} |
in an effort to explain the pleiotropic effects of the mutation producing this disorder , we postulated a defect in carbonic anhydrase ii ( ca ii ) , the only one of the three soluble isozymes of carbonic anhydrase that is known to be synthesized in kidney and brain . | NA | {
"id": "C0007034",
"name": "carbonic anhydrase ii",
"pos": [
116,
137
]
} | {
"id": "C0007028",
"name": "carbonic anhydrase",
"pos": [
196,
214
]
} |
the potency of the drug against all of these viruses is greater than that of 9- [ ( 2-hydroxyethoxy ) methyl ] guanine ( acyclovir ) . | NA | {
"id": "C0018321",
"name": "guanine",
"pos": [
111,
118
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
121,
130
]
} |
virus variants that induced altered virus thymidine kinase and became resistant to acyclovir were still as sensitive to dhpg as the parental virus . | NA | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
83,
92
]
} | {
"id": "C0017066",
"name": "dhpg",
"pos": [
120,
124
]
} |
dhpg is active against five different hsv variants with induced altered dna polymerase and resistance to acyclovir . | NA | {
"id": "C0017066",
"name": "dhpg",
"pos": [
0,
4
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
105,
114
]
} |
these observations indicate that in neurons the somatostatin prohormone or the nh2-terminal extension peptide of somatostatin-28 ( or both ) is stored and transported intracellularly along with somatostatin 14 . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
113,
128
]
} | {
"id": "C0037659",
"name": "somatostatin 14",
"pos": [
194,
209
]
} |
t-cell lines were started and propagated in long-term ( greater than 100 days ) cultures using the t-cell growth factor interleukin-2 ( il-2 ) . | NA | {
"id": "C0021758",
"name": "t-cell growth",
"pos": [
99,
112
]
} | {
"id": "C0021764",
"name": "interleukin",
"pos": [
120,
131
]
} |
central infusion of angiotensin ii , was without effect on the peripheral renin-angiotensin system or the sympathetic nervous system as gauged by the lack of change in plasma levels of angiotensin ii , norepinephrine , and epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
202,
216
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
223,
234
]
} |
on examination 1-3 days after return to sea level and compared with control rats , they exhibited pulmonary hypertension , reduced angiotensin-converting enzyme activity , greater vascular responsiveness to angiotensin ii ( aii ) , and resistance to blockade of aii pulmonary pressor responses by the aii antagonist , sa... | NA | {
"id": "C0003009",
"name": "aii",
"pos": [
224,
227
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
318,
327
]
} |
we have utilized an unanesthetized guinea pig model to study the cardiovascular effects of leukotriene d4 ( ltd4 ) , a compound implicated in slow reacting substance of anaphylaxis ( srs-a ) . | NA | {
"id": "C0023544",
"name": "leukotriene d4",
"pos": [
91,
105
]
} | {
"id": "C0038091",
"name": "slow reacting",
"pos": [
142,
155
]
} |
we examined the effect of an increase of endogenous prostaglandin production , induced by potassium depletion , on the urinary excretion of the norepinephrine metabolites metanephrine , normetanephrine and mhpg . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
144,
158
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
186,
201
]
} |
in 181 patients previously treated with isosorbide dinitrate ( isdn ) -retard , the mean daily dosage of nitrate was reduced from 77 mg ( 200 mg maximum ) isdn to 45 mg ( 120 mg maximum ) isosorbide 5-mononitrate in long-term treatment . | NA | {
"id": "C0022252",
"name": "isdn",
"pos": [
63,
67
]
} | {
"id": "C0064079",
"name": "isosorbide 5-mononitrate",
"pos": [
188,
212
]
} |
the effects of some old and new methylxanthines and 6-thioxanthines , i.e . theophylline ( th ) , caffeine ( caff ) , thiotheophyl line ( s-th ) , thiocaffeine ( s-caff ) , 8-phenyltheophylline ( 8-pt ) , 3-isobutyl-1-methyl-xanthine ( ibmx ) were compared at the level of adipose tissue on spontaneous and norepinephrin... | NA | {
"id": "C0039771",
"name": "th",
"pos": [
0,
2
]
} | {
"id": "C0000096",
"name": "3-isobutyl-1-methyl-xanthine",
"pos": [
205,
233
]
} |
in the latter model chloridarol significantly raised both the hdl cholesterol and the hdl/vldl + ldl cholesterol ratio . | NA | {
"id": "C0023822",
"name": "hdl cholesterol",
"pos": [
62,
77
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
101,
112
]
} |
alterations in the levels of cha , ache ( or bche ) and cholinergic receptors are not large enough to account for losses in cholinergic transmission in the cerebrum . | NA | {
"id": "C0001044",
"name": "ache",
"pos": [
35,
39
]
} | {
"id": "C0008429",
"name": "bche",
"pos": [
45,
49
]
} |
spontaneous formation of conjugates of alpha-methyl-dopa and dopa with serum proteins and experimental production of specific antibodies against these haptens . | NA | {
"id": "C0025741",
"name": "alpha-methyl-dopa",
"pos": [
39,
56
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
61,
65
]
} |
alpha-methyldopa ( alpha md ) and levodopa ( dopa ) react readily with serum proteins at alkaline ph and form stable conjugates with them . | NA | {
"id": "C0025741",
"name": "alpha-methyldopa",
"pos": [
0,
16
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
45,
49
]
} |
alpha-methyldopa ( alpha md ) and levodopa ( dopa ) react readily with serum proteins at alkaline ph and form stable conjugates with them . | NA | {
"id": "C0023570",
"name": "levodopa",
"pos": [
34,
42
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
45,
49
]
} |
hapten specific antibodies in high titers are produced in rabbits by inoculation of the conjugates formed by alpha md and dopa with normal rabbit serum ( alpha md-nrs and dopa-nrs ) , incorporated in incomplete fruend adjuvant . | NA | {
"id": "C0025741",
"name": "alpha md",
"pos": [
109,
117
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
171,
175
]
} |
high titers of antibodies directed against normal rabbit serum proteins as well as against human gamma globulin were also found in the sera of the rabbits immunized with alpha md-nrs and dopa-nrs conjugates incorporated in freund adjuvant . | NA | {
"id": "C0025741",
"name": "alpha md",
"pos": [
170,
178
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
187,
191
]
} |
second , it was shown that the pleasantness of both the sight and taste of food are modulated in a motivation-specific manner , in that in hungry and thirsty humans the pleasantness of the sight and taste of food but not water is decreased by eating to satiety , and the pleasantness of the sight and taste of water but ... | NA | {
"id": "C0043047",
"name": "water",
"pos": [
221,
226
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
345,
359
]
} |
chronic elevation of brain gaba by gamma-vinyl gaba treatment does not alter the sensitivity of gabaergic or dopaminergic receptors in rat cns . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
27,
31
]
} | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
35,
51
]
} |
rat brain gaba levels were elevated chronically by daily administration of gamma-vinyl gaba , an enzyme-activated , irreversible inhibitor of gaba:2-oxo-glutarate aminotransferase ( gaba-t ; ec2.6.1.19 ) . | NA | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
75,
91
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
182,
186
]
} |
nor did gamma-vinyl gaba treatment affect [ 3h ] gaba binding or gaba-activated [ 3h ] diazepam binding in the cerebral cortex . | NA | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
8,
24
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
65,
69
]
} |
thus , it appears that , in contrast to reported studies using chronic administration of other less specific gaba-t inhibitors such as gamma-acetylenic gaba , amino-oxyacetic acid and isonicotinic acid hydrazide or direct gaba agonists such as thip ( 4,5,6,7-tetrahydroisoxazolo ( 5,4-c- ) -pyridin-3-ol ) or kojic amine... | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
109,
113
]
} | {
"id": "C0048044",
"name": "gamma-vinyl",
"pos": [
323,
334
]
} |
in order to study the role of dopamine ( da ) in the regulation of seizure mechanisms in man , a non-emetic dose of apomorphine , a direct stimulant of da receptors , was administered to eight patients effected by different types of epilepsy . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
67,
74
]
} | {
"id": "C0014544",
"name": "types",
"pos": [
224,
229
]
} |
this effect is interpreted as being the result of a stimulation of da autoreceptors , mediating a decrease of dopaminergic activity in the central nervous system . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
67,
69
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
110,
122
]
} |
each of three benzodiazepine compounds ( chlordiazepoxide , flurazepam , diazepam ) reliably attenuated the magnitude of the conditioned bradycardia response as compared to vehicle controls . | NA | {
"id": "C0005064",
"name": "benzodiazepine compounds",
"pos": [
14,
38
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
41,
57
]
} |
evidence for existence and compactness of dna superstructure units in mammalian cells : a microdosimetric approach to radiation-induced dna release assayed by neutral sucrose gradient sedimentation . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
42,
45
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
192,
193
]
} |
we are reporting ten patients with osseous changes in the os pubic ( 4 ewing 's sarcoma , 1 osteosarcoma , 1 morbus hodgkin , 1 osteochondronecrosis , 2 osteochondritis , 1 subchronic osteomyelitis ) . | NA | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
71,
87
]
} | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
92,
104
]
} |
other analogs of cytidine containing modifications in the 5 position ( 5-aza-2'-deoxycytidine , 5-fluoro-2'-deoxycytidine , and pseudoisocytidine ) also induced the formation of striated muscle cells in treated cultures and inhibited dna methylation . | NA | {
"id": "C0010715",
"name": "cytidine",
"pos": [
17,
25
]
} | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
108,
121
]
} |
the enzyme complex provides for the cellular regulation of enzymatic activities by physical interaction of the proteins with each other and by prior alteration of one enzyme 's substrate by a related enzyme . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
4,
18
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
200,
206
]
} |
we have been the first to report that the mammalian cell enzymes responsible for modification of trna occur in enzyme complexes ( molecular weight 900000 daltons ) associated with aminoacyl-trna synthetases and that the activities of these enzymes differ in normal and leukemic cells . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
57,
64
]
} | {
"id": "C0026741",
"name": "enzyme complexes",
"pos": [
111,
127
]
} |
thus the enzymes responsible for the methylation of trna occur in enzyme complexes that provide efficient maturation of trna and possible regulation of protein synthesis . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
9,
16
]
} | {
"id": "C0026741",
"name": "enzyme complexes",
"pos": [
66,
82
]
} |
queuosine , located in the first position of the anticodon , is partly or completely replaced by guanosine in all tumor cells tested so far . | NA | {
"id": "C0028619",
"name": "queuosine",
"pos": [
0,
9
]
} | {
"id": "C0018330",
"name": "guanosine",
"pos": [
97,
106
]
} |
the hindiii a fragment of the ad2 dna which encodes the dbp has been methylated in vitro by the hpaii dna methyltransferase . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
12,
13
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
102,
105
]
} |
calcium emptying was highly related to npn emptying , demonstrating the important role of acid peptides ( phosphopeptides ) from casein hydrolysis . | NA | {
"id": "C0030956",
"name": "peptides",
"pos": [
95,
103
]
} | {
"id": "C0031684",
"name": "phosphopeptides",
"pos": [
106,
121
]
} |
pretreatment of mice with cloned human leukocyte interferon subtype a , ifn-alpha a , did not increase hexobarbital sleep time but pretreatment with mouse interferon or a hybrid human leukocyte interferon , ifn-alpha ad ( bgl ) , increased the duration of the effect of the barbiturate . | NA | {
"id": "C0019469",
"name": "hexobarbital",
"pos": [
103,
115
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
274,
285
]
} |
many new drugs with antipseudomonal activity , including penicillins , cephalosporins , and other beta-lactams , have been introduced in recent years and offer the potential for new approaches to therapy for these infections . | NA | {
"id": "C0030842",
"name": "penicillins",
"pos": [
57,
68
]
} | {
"id": "C0282215",
"name": "beta-lactams",
"pos": [
98,
110
]
} |
adult patients with bacterial infections of the lower respiratory tract were given either cefoperazone or cefamandole in a multicenter clinical study of the clinical and bacteriologic efficacy of cefoperazone . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
106,
117
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
196,
208
]
} |
satisfactory bacteriologic responses were noted for 88 % of the group given cefoperazone and 89 % of the group given cefamandole . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
76,
88
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
117,
128
]
} |
multicentered study of cefoperazone for treatment of intraabdominal infections and comparison of cefoperazone with cefamandole and clindamycin plus gentamicin for treatment of appendicitis and peritonitis . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
23,
35
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
115,
126
]
} |
fifty-seven of these patients received cefoperazone , 35 received cefamandole , and 52 received clindamycin plus gentamicin . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
39,
51
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
66,
77
]
} |
therapeutic efficacy could be evaluated in 20 patients who received cefoperazone , 20 who received cefamandole , and 16 who received clindamycin-gentamicin . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
68,
80
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
99,
110
]
} |
a randomized , controlled trial of cefoperazone vs. cefamandole-tobramycin in the treatment of putative , severe infections with gram-negative bacilli . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
35,
47
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
52,
63
]
} |
cefoperazone was compared with the combination of cefamandole and tobramycin in a prospective , randomized study of putative , severe , gram-negative bacillary infections . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
0,
12
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
50,
61
]
} |
infection was cured or improved in 77 % of cefoperazone-treated patients and 81 % of cefamandole-tobramycin-treated patients . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
43,
55
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
85,
96
]
} |
bacteremia was cured or improved in 61 % of cefoperazone-treated patients and in 63 % of cefamandole-tobramycin-treated patients . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
44,
56
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
89,
100
]
} |
this analysis suggests that cefoperazone alone may be as effective as cefamandole plus tobramycin in the treatment of severe infections with gram-negative bacilli and is less nephrotoxic . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
28,
40
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
70,
81
]
} |
evaluation of the treatment of 501 patients with pelvic infections and a review of the literature indicate that prospects for clinical cure without surgical intervention are markedly better in women seen early in the course of infection than in those with well-established infections . | NA | {
"id": "C0030790",
"name": "pelvic infections",
"pos": [
49,
66
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
273,
282
]
} |
based on their own experience , the authors report that a fall in the complement level of joint fluid , which is particularly common in rhumatoid arthritis , is also seen in cases of systemic lupus eryrthematosis and a variety of arthritis : infectious arthritis , gout , articular chondrocalcinosis and psoriatic rheuma... | NA | {
"id": "C0003864",
"name": "arthritis",
"pos": [
146,
155
]
} | {
"id": "C0553730",
"name": "articular chondrocalcinosis",
"pos": [
272,
299
]
} |
a second distinctive cell population was non-phagocytic , occasionally binucleate , and had abundant ia antigens but lacked igg fc receptors , monocyte lineage antigens , b or t lymphocyte antigens , and fibroblast-associated antigens detected by reagents raised against synovial cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
21,
25
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
204,
214
]
} |
an additional population , designated type iii , contained nearly all of the remaining cells and was defined by the presence of antigens expressed primarily on fibroblasts and by the absence of phagocytosis , demonstrable ia antigens , and four antigens of the monocyte lineage . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
87,
92
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
160,
171
]
} |
there was an association of reflux esophagitis and duodenal ulcer in old age : in patients with reflux esophagitis aged over 60 years , duodenal ulcer was found twice as often as in elderly patients without esophagitis . | NA | {
"id": "C0014869",
"name": "reflux esophagitis",
"pos": [
28,
46
]
} | {
"id": "C0014868",
"name": "esophagitis",
"pos": [
207,
218
]
} |
the clinical profile of aminoglutethimide ( ag ) , an amino derivative of the hypnotic agent glutethimide , is described . | NA | {
"id": "C0002555",
"name": "aminoglutethimide",
"pos": [
24,
41
]
} | {
"id": "C0017845",
"name": "glutethimide",
"pos": [
93,
105
]
} |
6 of the 14 patients had had typical episodes of pancreatitis , in 6 other patients there was clinical and biochemical evidence of pancreatic disease ( mainly pain and hyperenzymemia ) , and the last 2 cases had chronic epigastric pain without biochemical abnormalities . | NA | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
49,
61
]
} | {
"id": "C0030286",
"name": "of pancreatic disease",
"pos": [
128,
149
]
} |
three cases are described which show the typical range of infections which may be caused by actinobacillus actinomycetemcomitans , namely an actinomycosis-like infection , a prosthetic cardiac valve endocarditis and a post-traumatic soft-tissue infection . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
58,
67
]
} | {
"id": "C0149778",
"name": "soft-tissue infection",
"pos": [
233,
254
]
} |
elevated levels of plasma uroporphyrin and 7-cooh porphyrin were detected alongside a predominant isocoproporphyrin fraction in the faeces by means of quantitative thin-layer chromatography , confirming the diagnosis of overt pct . | NA | {
"id": "C0042093",
"name": "uroporphyrin",
"pos": [
26,
38
]
} | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
106,
115
]
} |
both showed a significant rise in antibody titre to enterotoxin b produced by the offending staphylococci , suggesting that this toxin was responsible for the tss . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
52,
63
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
129,
134
]
} |
development of chlamydospores was induced by n-acetyl hexosamines , especially n-acetyl-d-glucosamine , and this induction did not depend on non-specific utilization of n-acetyl hexosamines as metabolic sources nor did it correlate with induction of germ-tube formation . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
90,
101
]
} | {
"id": "C0019478",
"name": "hexosamines",
"pos": [
178,
189
]
} |
thus , unlike in systemic lupus erythematosus , antibodies to ds-dna and ss-dna with their capacity to form immune complexes are unlikely to be of major importance in the pathogenesis of cryptogenic fibrosing alveolitis . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
48,
58
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
108,
124
]
} |
a fraction of low molecular weight low sulfated heparin , did not significantly increase the binding of fibrinogen , except in one case for which the binding of fibrinogen to platelets was largely increased by standard heparin . | NA | {
"id": "C0019139",
"name": "low",
"pos": [
14,
17
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
219,
226
]
} |
vasoconstricting agents , namely , epinephrine , norepinephrine , phenylephrine , and serotonin exerted hypertensive effects in a dose-dependent fashion ( 0.1-3.0 micrograms ) ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
35,
46
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
49,
63
]
} |
further experiments indicated that ( a ) more factor x is activated per mg tissue factor than per mg of activated partial thromboplastin and ( b ) more thrombin is generated per unit of factor xa in the presence of tissue factor than in the presence of activated partial thromboplastin . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
46,
54
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
186,
195
]
} |
thus , the two pathways differ not only by the mechanism of factor x activation but also by the extent to which prothrombin is activated by factor xa . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
60,
68
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
140,
149
]
} |
in the present study , cephaloridine markedly decreased gsh in rat and rabbit renal cortex while concomitantly increasing oxidized glutathione ( gssg ) . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
56,
59
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
145,
149
]
} |
hepatic aryl hydrocarbon hydroxylase ( ahh ) and aniline hydroxylase ( anh ) activities were influenced by dietary protein , primarily at 6 , 18 , and 30 weeks , and these values tended to decline between maturity and senescence . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
8,
36
]
} | {
"id": "C0003039",
"name": "aniline",
"pos": [
49,
56
]
} |
simultaneous liquid chromatographic determination of chloramphenicol and antiepileptic drugs ( phenobarbital , phenytoin , carbamazepine , and primidone ) in plasma . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
95,
108
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
143,
152
]
} |
a method for the simultaneous analysis of chloramphenicol and four antiepileptic drugs ( phenobarbital , phenytoin , carbamazepine , and primidone ) in plasma by high-performance liquid chromatography ( hplc ) is described . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
89,
102
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
137,
146
]
} |
the effects of age and associated therapy on plasma primidone ( prm ) and derived phenobarbital ( pb ) concentrations , and on plasma concentrations-to-prm dose ratios ( l/d ratio ) were evaluated retrospectively from 408 consecutive prm and derived pb determinations in 238 chronically treated epileptic patients ( 153 ... | NA | {
"id": "C0033148",
"name": "prm",
"pos": [
64,
67
]
} | {
"id": "C0031412",
"name": "pb",
"pos": [
250,
252
]
} |
significant differences in mean plasma prm and pb l/d ratios were found between patients aged 0-3 years , 4-9 years , 10-15 years , and adults ( 16-55 years ) , with higher values in the older groups . | NA | {
"id": "C0033148",
"name": "prm",
"pos": [
39,
42
]
} | {
"id": "C0031412",
"name": "pb",
"pos": [
47,
49
]
} |
concomitant treatment with carbamazepine affected prm disposition and led to increased l/d ratios for pb and decreased l/d ratios for prm , whereas phenytoin increased the l/d ratios for pb without any significant change in the l/d ratios for prm . | NA | {
"id": "C0031412",
"name": "pb",
"pos": [
102,
104
]
} | {
"id": "C0033148",
"name": "prm",
"pos": [
243,
246
]
} |
to characterize these b cell lymphocytotoxins we have used a mouse monoclonal anti-dr antibody ( l227 ) that inhibits cytotoxicity of antibodies against hla-dr antigens and a chicken serum against human ia-like antigens that also inhibits antibodies against dr-related supertypic determinants and other class ii histocom... | NA | {
"id": "C0019764",
"name": "hla-dr antigens",
"pos": [
153,
168
]
} | {
"id": "C0019754",
"name": "human ia-like",
"pos": [
197,
210
]
} |
an enzyme immunoassay was applied to stepless antibody determination in sera from patients with paragonimiasis africanus , paragonimiasis uterobilateralis , paragonimiasis ecuadoriensis , other helminthic infestation , non parasitic diseases and healthy individuals . | NA | {
"id": "C0018889",
"name": "helminthic infestation",
"pos": [
194,
216
]
} | {
"id": "C0030499",
"name": "parasitic",
"pos": [
223,
232
]
} |
on the basis of the experience with the treatment of injuries of 69 nerves of hands in 36 patients the authors came to a conclusion that the microsurgical technique can return the finest sensitivity of skin denervation resulting from a trauma . | NA | {
"id": "C0018571",
"name": "of",
"pos": [
13,
15
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
236,
242
]
} |
exposure to polychlorinated biphenyl compounds ( pcbs ) has resulted in a variety of cutaneous effects in several species . | NA | {
"id": "C0032447",
"name": "polychlorinated biphenyl",
"pos": [
12,
36
]
} | {
"id": "C0005580",
"name": "pcbs",
"pos": [
49,
53
]
} |
three cosmid clones containing overlapping v-fms homologous cellular dna inserts , representing a contiguous region of cellular dna sequence of approximately 64 kb in length , were isolated . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
69,
72
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
185,
186
]
} |
although early or prereplicative viral proteins are detected with each mutant both in vivo and after in vitro translation of isolated rna , few , if any , late proteins are observed under any conditions . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
33,
47
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
160,
168
]
} |
the viral specificity assessed by membrane immunofluorescence and virus-binding radioimmunoassay indicated that the reactivity of these antibodies was distinctly different from monoclonal antibodies recovered from ( b6 x d2 ) f1 recipients of d2 spleen cells reported previously ( portis et al. , virology 118 , 181-190 ... | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
136,
146
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
177,
187
]
} |
ten out of 17 monoclonal antibodies in the current study reacted exclusively with mcf viruses and three of these antibodies detected envelope determinants which were shared by a broad panel of mcf viruses of diverse origin . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
14,
35
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
113,
123
]
} |
not infrequently , such animals developed a severe pathological process accompanied by growth retardation and characterized by progressive involvement of the hypothalamus , immunocompetent organs , endocrine system and always terminating by the death of the animals . | NA | {
"id": "C0030660",
"name": "pathological process",
"pos": [
51,
71
]
} | {
"id": "C0011065",
"name": "terminating",
"pos": [
226,
237
]
} |
also the percent zinc-binding capacity of serum , a good indicator for estimating the zinc supply status of rats , showed a better zinc supply of the citrate group with 5 as well as 10 ppm dietary zinc , compared with the other groups on the same dietary zinc content . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
17,
21
]
} | {
"id": "C0772239",
"name": "zinc",
"pos": [
255,
259
]
} |
for the clinical practice methods of the determination of hdl-cholesterol made their way which are based on the precipitation of apolipoprotein-b-containing lipoproteins and a determination of cholesterol following . | NA | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
58,
73
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
193,
204
]
} |
in 50 pregnancies morphometric parameters of the placenta and the serum estriol values in the third trimester were correlated . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
6,
17
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
94,
109
]
} |
during pregnancy application of prostaglandins has been proved a successful method both for induction of midtrimester artificial abortion and cervical priming before termination of pregnancy at the end of first trimester . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
7,
16
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
205,
220
]
} |
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