text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
insofar as lysosomal phospholipidosis is an early sign of intoxication by aminoglycosides , these results may serve as a basis for the development or screening of less toxic compounds in this class of antimicrobial agents . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
74,
89
]
} | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
201,
221
]
} |
the addition of nucleoside and deoxyribonucleoside deaminase inhibitors , which leads to the incorporation of 5-halogenated analogs of deoxycytidine into dna as such , does not impair their antiviral activity . | NA | {
"id": "C0028621",
"name": "nucleoside",
"pos": [
16,
26
]
} | {
"id": "C0011528",
"name": "deoxyribonucleoside",
"pos": [
31,
50
]
} |
the in vitro activities of three new beta-lactam antimicrobial agents , cefodizime , ceftazidime , and aztreonam ( formerly azthreonam ) , were compared with those of cefotaxime , cefuroxime , cefoxitin , and penicillin against 100 beta-lactamase-negative and 42 beta-lactamase-positive neisseria gonorrhoeae strains . | NA | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
37,
48
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
209,
219
]
} |
the in vitro activities of three new beta-lactam antimicrobial agents , cefodizime , ceftazidime , and aztreonam ( formerly azthreonam ) , were compared with those of cefotaxime , cefuroxime , cefoxitin , and penicillin against 100 beta-lactamase-negative and 42 beta-lactamase-positive neisseria gonorrhoeae strains . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
167,
177
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
180,
190
]
} |
biochemical analysis of the medium and cultures indicated that one or more of the oxidation products of l-ascorbic acid , e.g. , l-dehydroascorbic acid or l-diketogulonic acid , were more effective inhibitors than was reduced l-ascorbic acid . | NA | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
131,
151
]
} | {
"id": "C0003968",
"name": "l-ascorbic acid",
"pos": [
226,
241
]
} |
the substances which are precursors to the bacteriostatic agent can be fractionated on the basis of molecular size and charge and have properties which indicate that they are fragments of lactoferrin , an iron-binding glycoprotein . | NA | {
"id": "C0022942",
"name": "lactoferrin",
"pos": [
188,
199
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
218,
230
]
} |
thus , the enzyme can bind nadp+ , nad+ , and glucose 6-phosphate , but the enzyme-glucose 6-phosphate complex can react only with nad+ , not with nadp+ . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
11,
17
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
76,
82
]
} |
the results are interpreted in terms of atp addition to binary enzyme-coenzyme and enzyme-glucose 6-phosphate complexes . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
63,
69
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
83,
89
]
} |
the method enables rapid separation and identification of components in mixtures of carbohydrate chains from glycosphingolipids containing up to six simple sugars . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
84,
96
]
} | {
"id": "C0026492",
"name": "simple sugars",
"pos": [
149,
162
]
} |
the degree of control was at least as good after five months ' blood glucose monitoring at home ( mean blood glucose 9.3 +/- sem 2.9 mmol/l , mean 24 hour glucose excretion 113 +/- sem 168 mmol/l ) as after five months ' urine testing ( mean blood glucose 11.1 +/- sem 4.1 mmol/l , mean 24 hour glucose excretion 141 +/-... | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
63,
76
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
295,
302
]
} |
the occurrence of circulating iga-class aga is compatible with the hypothesis that these antibodies can be deposited in the skin , e.g . as immune complexes , or due to cross-reactivity of gliadin and dermal reticulin . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
89,
99
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
140,
156
]
} |
beer was the most popular beverage , and 25 ( 41 % ) of those with gout consumed more than 60 g alcohol daily ( equivalent to 2 . 5 litres of beer ) . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
96,
103
]
} | {
"id": "C0004922",
"name": "beer",
"pos": [
142,
146
]
} |
patients with ankylosing spondylitis , psoriatic arthritis , and psoriasis alone were typed for hla a , b , cw , and dr antigens , and the antigen frequencies were compared with those in a normal control population and in patients with rheumatoid arthritis . | NA | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
39,
58
]
} | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
65,
74
]
} |
pretreatments of rats with gamma-vinyl gaba ( 900 mg/kg ) elevated brain gaba levels and prevented the occurrence of convulsions and aphagia . | NA | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
27,
43
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
73,
77
]
} |
the situation of finding the corpse , bleedings inside the iliac muscles , little hemorrhages in the mucosa of the stomach and acetone in blood and urine pointed to a death lately from cold . | NA | {
"id": "C0006629",
"name": "corpse",
"pos": [
29,
35
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
167,
172
]
} |
the association of ventricular extrasystoles and antidromic reciprocating rhythm and their morphological identity suggest that these extrasystoles were in fact automatic activity of the kent bundle . | NA | {
"id": "C0151636",
"name": "ventricular extrasystoles",
"pos": [
19,
44
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
133,
146
]
} |
a series of 12 ects reduced urinary norepinephrine and normetanephrine output significantly , and showed a tendency to reduce urinary vanillylmandelic acid output as well as whole-body norepinephrine turnover . | NA | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
55,
70
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
185,
199
]
} |
treatment with lithium carbonate significantly reduced urinary norepinephrine , normetanephrine , 3-methoxy-4-hydroxyphenylglycol , and vanillylmandelic acid output as well as whole-body norepinephrine turnover . | NA | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
80,
95
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
187,
201
]
} |
the hepatic reduced glutathione ( gsh ) was depleted in 3 h to 20 % and the gssg to half of the value in controls . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
34,
37
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
76,
80
]
} |
conventional histology and electron microscopy disclosed histiocyte- , fibroblast- and osteoclast-like multinucleated giant cells , cells with 2 and 3 nuclei , and undifferentiated cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
71,
81
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
181,
186
]
} |
in the general population exposed to the effect of quite low doses of carcinogens the latter are probably only initiators of neoplastic process completed by specific and nonspecific stimulators of carcinogenesis ( cocarcinogens , promoters ) . | NA | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
125,
143
]
} | {
"id": "C0596263",
"name": "carcinogenesis",
"pos": [
197,
211
]
} |
our spect studies of rcbf in a group of 18 patients with seizure disorders , when compared with studies in 32 normal control subjects , have shown enhanced flow to an active seizure focus and ischemia of brain areas in certain subjects between seizures . | NA | {
"id": "C0014544",
"name": "seizure disorders",
"pos": [
57,
74
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
244,
252
]
} |
these have included autogenous fresh , irradiated , or frozen bone , and polytetrafluoroethylene carbon fiber sponge ( proplast ) . | NA | {
"id": "C0032611",
"name": "polytetrafluoroethylene",
"pos": [
73,
96
]
} | {
"id": "C0033485",
"name": "proplast",
"pos": [
119,
127
]
} |
a 1000/ml increase in leucocyte count was typically associated with a decrease in hdl-c by 1 mg/dl and an increase in ldl-c and vldl-c of 1 mg/dl each . | NA | {
"id": "C0008377",
"name": "hdl-c",
"pos": [
82,
87
]
} | {
"id": "C0023824",
"name": "ldl-c",
"pos": [
129,
134
]
} |
a 1000/ml increase in leucocyte count was typically associated with a decrease in hdl-c by 1 mg/dl and an increase in ldl-c and vldl-c of 1 mg/dl each . | NA | {
"id": "C0008377",
"name": "hdl-c",
"pos": [
82,
87
]
} | {
"id": "C0023826",
"name": "vldl-c",
"pos": [
128,
134
]
} |
temporal aspects of the acoustic reflex response were estimated for normally hearing subjects , subjects with noise-induced hearing loss and children with sensorineural hearing impairment . | NA | {
"id": "C0018781",
"name": "noise-induced hearing loss",
"pos": [
110,
136
]
} | {
"id": "C0018784",
"name": "sensorineural hearing impairment",
"pos": [
155,
187
]
} |
endotoxin content was the highest in lps-protein antigen , followed by kscn , na salicylate , and saline extract in that order . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
0,
9
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
37,
40
]
} |
to test the applicability of the new catheter tip manometer , cardiac hemodynamic parameters were determined in rats under various pathophysiologic conditions : several periods of asphyxia were followed by progressive depressions in heart rate , lvsp and lv dp/dtmax , and acute as well as chronic stimulation with catec... | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
315,
329
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
350,
363
]
} |
for the hitherto unexplored apoproteins from egg yolk of the duck ( anas platyrhynchos ) the method has now been used to isolate three new proteins , two of which were not readily separated by methods based on molecular size . | NA | {
"id": "C0003601",
"name": "apoproteins",
"pos": [
28,
39
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
139,
147
]
} |
cardiac phospholipid-sensitive ca2+-dependent protein kinase phosphorylated cardiac troponin inhibitory subunit ( troponin i ) and tropomyosin-binding subunit ( troponin t ) , present either as the free form or as the troponin-tropomyosin complex . | NA | {
"id": "C0041199",
"name": "troponin i",
"pos": [
84,
94
]
} | {
"id": "C0077404",
"name": "troponin t",
"pos": [
161,
171
]
} |
these findings indicate that troponin i and troponin t were effective substrates for this species of ca2+-dependent protein kinase , suggesting its potential regulatory role in the contractile activity of myofibrils modulated by troponin . | NA | {
"id": "C0077404",
"name": "troponin t",
"pos": [
44,
54
]
} | {
"id": "C0041199",
"name": "troponin",
"pos": [
229,
237
]
} |
both proteolytic enzymes selectively cleaved the chain-terminating thioester hydrolase component from the enzyme complex , leaving all other partial activities intact in the core peptides . | NA | {
"id": "C0030940",
"name": "proteolytic enzymes",
"pos": [
5,
24
]
} | {
"id": "C0020289",
"name": "hydrolase",
"pos": [
77,
86
]
} |
gel-permeation high-performance liquid chromatography as a powerful technique for rapid analysis of calcitriol ( 1,25-dihydroxycholecalciferol ) receptors . | NA | {
"id": "C0006674",
"name": "calcitriol",
"pos": [
100,
110
]
} | {
"id": "C0012328",
"name": "dihydroxycholecalciferol",
"pos": [
118,
142
]
} |
at the same time the coenzyme pyridoxal phosphate becomes irreversibly bound to the enzyme protein . | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
21,
29
]
} | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
30,
49
]
} |
immunoprecipitation of periodate/nab3h4-labelled human erythrocytes using anti-wrightb ( wrb ) monoclonal antibodies showed that these antibodies specifically react with the major erythrocyte sialoglycoprotein alpha ( glycophorin a ) . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
95,
116
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
135,
145
]
} |
the fractions were treated with hno2 at ph 1.5 , and the resulting mixtures of oligosaccharides were reduced with nab3h4 and analysed for their disaccharide composition by paper chromatography and by high-pressure liquid chromatography . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
79,
95
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
144,
156
]
} |
both human synovial tissue in culture and lectin-stimulated mononuclear leucocytes produced a protein that induced proteoglycan resorption in explants of bovine nasal cartilage and human articular cartilage . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
42,
48
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
94,
101
]
} |
the reactivity of lysine-18 of troponin i to acetimidate was much diminished when the troponin i was complexed in the presence of ca2+ with troponin c alone or in the whole troponin complex . | NA | {
"id": "C0077401",
"name": "troponin",
"pos": [
31,
39
]
} | {
"id": "C0041199",
"name": "troponin complex",
"pos": [
173,
189
]
} |
in the presence of egta , lysine-18 of troponin i in the troponin i-troponin c complex was more reactive to acetimidate than it was in the presence of ca2+ . | NA | {
"id": "C0077401",
"name": "troponin i",
"pos": [
39,
49
]
} | {
"id": "C0041199",
"name": "troponin",
"pos": [
68,
76
]
} |
precipitation of the casein at ph 4.6 and filtration of the resultant acid whey on sephadex g-25 led , however , to the recovery of about 90 % of the zinc as a compound of low molecular weight , which was tentatively identified as zinc citrate . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
150,
154
]
} | {
"id": "C0772239",
"name": "zinc",
"pos": [
231,
235
]
} |
rb+ ions , and to a smaller extent other univalent cations , also activate by acting as analogues of nh4+ . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
4,
8
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
51,
58
]
} |
porphyrin concentrations were limited to 0.001-0.1 microm and 0.01-1 microm for protoporphyrin and haematoporphyrin respectively , where dimerization is the dominant aggregation process . | NA | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
0,
9
]
} | {
"id": "C0033733",
"name": "protoporphyrin",
"pos": [
80,
94
]
} |
correlated with this loss is the differential appearance of three major groups of non-histone nuclear proteins . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
86,
93
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
94,
110
]
} |
separation of glucose and hexose monophosphate from the tissues was performed by paper chromatography and t.l.c. , and the 3h and 14c radioactivities in these compounds were measured . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
14,
21
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
26,
32
]
} |
on glycosidase treatment , the positions of the 32p-labelled heavy chains were affected by neuraminidase but not by endo-beta-n-acetylglucosaminidase h . | NA | {
"id": "C0017976",
"name": "glycosidase",
"pos": [
3,
14
]
} | {
"id": "C0027803",
"name": "neuraminidase",
"pos": [
91,
104
]
} |
the relationship between placental protein synthesis and transfer of amino acids from mother to foetus was studied in the guinea pig , by using [ u-14c ] -lysine , -leucine , -glycine , -aspartate and -alpha-aminoisobutyrate . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
69,
80
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
176,
183
]
} |
high voltage electrophoresis showed the peptide to be one component ( mgly 2.49 ) with an electrophoretic mobility different from bradykinin , lysyl-bradykinin and methionyl-lysyl-bradykinin . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
130,
140
]
} | {
"id": "C0022474",
"name": "lysyl-bradykinin",
"pos": [
174,
190
]
} |
our data suggest that both monofunctional and bifunctional psoralens produce 1o2 and o-.2 , and these reactive forms of oxygen may contribute to the development of skin cancer and membrane-damaging effects of these furocoumarins . | NA | {
"id": "C0033858",
"name": "psoralens",
"pos": [
59,
68
]
} | {
"id": "C0016859",
"name": "furocoumarins",
"pos": [
215,
228
]
} |
heparin and dermatan sulfate which were eluted from the affinity column catalyzed the inhibition of thrombin by heparin cofactor ii to a greater degree than did the respective unfractionated mucopolysaccharides . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
0,
7
]
} | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
191,
210
]
} |
cytosolic epoxide hydrolase was purified from male swiss mouse liver cytosol by passing it sequentially through cm-cellulose , deae-cellulose , phenylsepharose , deae-cellulose , and hydroxyapatite . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
115,
124
]
} | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
162,
176
]
} |
captopril , n- ( 1 ( s ) -carboxy-3-phenyl-propyl ) -l-alanyl-l-proline , n- ( 1 ( s ) -carboxy-3-phenyl-propyl ) -l-lysyl-l-proline , teprotide , thiorphan and s-acetylcaptopril each have similar potencies for inhibition of [ 3h ] captopril binding and of angiotensin converting enzyme . | NA | {
"id": "C0033382",
"name": "l",
"pos": [
8,
9
]
} | {
"id": "C0006938",
"name": "captopril",
"pos": [
232,
241
]
} |
the potential use of immobilized s-adenosyl-l-homocysteine in the differential separation of phenylethanolamine n-methyltransferase from other methyltransferase enzymes is discussed . | NA | {
"id": "C0031397",
"name": "phenylethanolamine n-methyltransferase",
"pos": [
93,
131
]
} | {
"id": "C0025831",
"name": "methyltransferase",
"pos": [
143,
160
]
} |
treatment of synaptic membranes from rat brainstem and spinal cord with the nonionic detergent triton x-100 at 1-10 microliters/mg protein caused a marked increase in glycine receptor ( 3h ) strychnine binding expressed per mg of residual membrane protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
131,
138
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
239,
255
]
} |
the enzyme was partially purified from rat liver supernatant as two isoenzyme ( ca . 40,000 and 70,000 dalton ) . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
4,
10
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
68,
77
]
} |
extra release of both oxidized ( gssg ) and reduced ( gsh ) glutathione into bile contributed to this depletion . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
33,
37
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
60,
71
]
} |
glutathione excretion into bile accounted for only part of liver glutathione loss , thus indicating that , in addition to the gsh-peroxidase reaction ( resulting in gssg generation ) , other glutathione-related processes were involved in nifurtimox detoxification . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
165,
169
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
191,
202
]
} |
the inhibition of type a mao persisted for several days after a single 10 mg/kg i.p . dose of ly121768 and was associated with a significant increase in brain dopamine , norepinephrine and epinephrine concentrations and a significant decrease in the concentration of the dopamine metabolites , homovanillic acid and 3,4-... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
170,
184
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
189,
200
]
} |
this could be a result of acetylation of the drug-carrier protein , albumin , and other proteins carried into inflamed tissues and this acetylation could have marked consequences for the functions of these proteins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
68,
75
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
206,
214
]
} |
when cultured human skin fibroblasts were incubated at 37 degrees c with sonically dispersed positively charged sphingomyelin liposomes , sphingomyelin accumulated within the cell . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
25,
36
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
175,
179
]
} |
neither low density lipoprotein cholesterol nor nonlipoprotein cholesterol could suppress the sphingomyelin-induced cholesterol synthesis or activate the acyl-coa cholesterol acyltransferase , despite an increase in cell cholesterol content . | NA | {
"id": "C0023824",
"name": "low density lipoprotein cholesterol",
"pos": [
8,
43
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
221,
232
]
} |
resultant accumulation of cholesteryl esters in the presence of extracellular cholesterol could be relevant to atherogenesis . | NA | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
26,
44
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
78,
89
]
} |
the results support the hypothesis : prefattened overweight hamsters lost more weight from the time of mating to the end of lactation than did unmanipulated controls . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
49,
59
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
79,
85
]
} |
a total reduction of other aromatic aminoacids can also explain , through a reduced intestinal absorption , the decrease of the tryptophan in the nephrotic syndrome . | NA | {
"id": "C0301713",
"name": "aromatic aminoacids",
"pos": [
27,
46
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
128,
138
]
} |
this method gives rise to the iodine derivatives of aldehydes ( 2-hydroxy- and 4-hydroxy-3,5-diiodobenzaldehyd ) , ketones ( 2-hydroxy-5-iodo- , 2-hydroxy-3,5-diiodo- and 4-hydroxy-3,5-diiodo-acetophenone , 4-hydroxy-3,5-diiodo-propiophenone ) , acids ( 3,5-diiodo-4-hydroxybenzoic acid , 3-formyl-4-hydroxy-5-iodobenzoi... | NA | {
"id": "C0022634",
"name": "ketones",
"pos": [
115,
122
]
} | {
"id": "C0001006",
"name": "acetophenone",
"pos": [
192,
204
]
} |
1 chlorambucil ( 10 mg ) and prednimustine ( 20 mg ) , the prednisolone ester of chlorambucil , were administered orally on separate occasions to six patients . | NA | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
2,
14
]
} | {
"id": "C0032949",
"name": "prednisolone ester",
"pos": [
59,
77
]
} |
4 following prednimustine no parent drug or alkylating metabolites ( chlorambucil or phenyl acetic mustard ) could be detected in the plasma . | NA | {
"id": "C0032949",
"name": "prednimustine",
"pos": [
12,
25
]
} | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
69,
81
]
} |
6 it is concluded that : a. the bioavailability of orally administered prednimustine is much lower than that of chlorambucil . | NA | {
"id": "C0032949",
"name": "prednimustine",
"pos": [
71,
84
]
} | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
112,
124
]
} |
in this study the substrate specificity of the two forms has been further delineated by correlating activities in different individuals with various substrates . m-tyramine , noradrenaline , adrenaline , 5-hydroxytryptamine , p-hydroxyamphetamine , isoprenaline , salbutamol and l-naphthol were all specific substrates f... | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
175,
188
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
191,
201
]
} |
3 the frequency of adrs was higher in 402 patients with cirrhosis ( 27.4 % ) than in 661 with renal dysfunction ( 22.8 % ) and in 249 with other parenchymatous liver diseases ( 13.7 % ) or in 1,270 patients with neither liver diseases nor renal dysfunction ( 10.9 % ) ( chi 2 3 = 85.53 , p less than 0.001 ) . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
56,
65
]
} | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
220,
234
]
} |
we have investigated the regression phenomenon which occurs when ebv-infected peripheral blood mononuclear cells from seropositive individuals are cultured for one month at high cell concentration and have confirmed that regression is mediated by e+ lymphocytes . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
78,
112
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
178,
182
]
} |
collagen treated with both formaldehyde and glutaraldehyde proved increasingly toxic with increase in the concentrations of aldehyde used . | NA | {
"id": "C0017814",
"name": "glutaraldehyde",
"pos": [
44,
58
]
} | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
124,
132
]
} |
we have assessed the effects of the diphosphonate , dichloromethylene diphosphonate ( cl2mdp ) , in 19 patients with hypercalcaemia and increased bone resorption due to myeloma . | NA | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
36,
49
]
} | {
"id": "C0012081",
"name": "cl2mdp",
"pos": [
86,
92
]
} |
when the birthweights of the 137 liveborn infants were corrected for maternal height and weight , sex and birth rank , 37 ( 27 % ) fell below the 10th centile of normal birthweight standards . | NA | {
"id": "C0005612",
"name": "birthweights",
"pos": [
9,
21
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
174,
180
]
} |
several chorismate and adamantane derivatives , as well as 2-hydroxyphenyl acetate and diethyl malonate , act as linear competitive inhibitors with respect to chorismate in the mutase reaction and with respect to chorismate in the mutase reaction and with respect to prephenate in the dehydrogenase reaction . | NA | {
"id": "C0008514",
"name": "chorismate",
"pos": [
8,
18
]
} | {
"id": "C0524938",
"name": "mutase",
"pos": [
231,
237
]
} |
we see no change in the size of pde upon activation by light and 100 microm guanosine 5'- ( beta , gamma-imidotriphosphate ) ( gpp [ nh ] p ) compared with pde in dark with 260 microm gtp . | NA | {
"id": "C0018366",
"name": "gpp [ nh ] p",
"pos": [
127,
139
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
184,
187
]
} |
the present work has demonstrated the utility of the diamagnetic lanthanides lutetium and lanthanum as metal binding probes for a synthetic 13-residue fragment representing calcium binding site 3 of rabbit skeletal troponin c ( residues 103-115 ) . | NA | {
"id": "C0205838",
"name": "lanthanides",
"pos": [
65,
76
]
} | {
"id": "C0024170",
"name": "lutetium",
"pos": [
77,
85
]
} |
the present work has demonstrated the utility of the diamagnetic lanthanides lutetium and lanthanum as metal binding probes for a synthetic 13-residue fragment representing calcium binding site 3 of rabbit skeletal troponin c ( residues 103-115 ) . | NA | {
"id": "C0205838",
"name": "lanthanides",
"pos": [
65,
76
]
} | {
"id": "C0023031",
"name": "lanthanum",
"pos": [
90,
99
]
} |
in g0 lymphocytes histone synthesis accounts for at least 6 % of nuclear protein radioactivity , and the rate of synthesis is about 2-3 % of that of s phase lymphocytes . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
18,
25
]
} | {
"id": "C0028589",
"name": "nuclear protein",
"pos": [
65,
80
]
} |
the technique of immunoblotting revealed that the antiserum reacted virtually exclusively with the high molecular weight polypeptide that comigrates with hmwp in cell lysates and in zncl2-stabilized plasma membrane ghosts prepared from hela cells [ gruenstein , e. , rich , a. , & weihing , r. r. ( 1975 ) j. cell biol .... | NA | {
"id": "C0026042",
"name": "microtubule proteins",
"pos": [
395,
415
]
} | {
"id": "C0041348",
"name": "tubulin",
"pos": [
427,
434
]
} |
at ph greater than 7 the absorption and magnetic circular dichroic spectra of cobalt carboxypeptidase a are insensitive to anions [ latt , s. a. , & vallee , b. l. ( 1971 ) biochemistry 10 , 4263-4270 ] , but at ph less than 6 chloride and other anions perturb them in a manner specific for each anion . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
227,
235
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
296,
301
]
} |
class i isoenzymes of alcohol dehydrogenase ( adh ) were isolated by chromatography of human liver homogenates on deae-cellulose , 4- [ 3- [ n- ( 6-aminocaproyl ) -amino ] propyl ] pyrazole -- sepharose and cm-cellulose . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
114,
128
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
210,
219
]
} |
eight isoenzymes of different subunit composition ( alpha gamma 2 , gamma 2 gamma 2 , alpha gamma 1 , alpha beta 1 , beta 1 gamma 2 , gamma 1 gamma 1 , beta 1 gamma 1 , and beta 1 beta 1 ) were purified , and their activities were measured at ph 10.0 by using ethanol , ethylene glycol , methanol , benzyl alcohol , octa... | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
260,
267
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
288,
296
]
} |
km values for methanol and ethylene glycol were from 5- to 100-fold greater than those for ethanol , depending on the isoenzyme , while those for benzyl alcohol , octanol , and 16-hydroxyhexadecanoic acid were usually 100-1000-fold lower than those for ethanol . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
14,
22
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
253,
260
]
} |
the homodimer beta 1 beta 1 had the lowest kcat/km value for all alcohols studied except methanol and ethylene glycol ; | NA | {
"id": "C0001975",
"name": "alcohols",
"pos": [
65,
73
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
89,
97
]
} |
ethanol proved to be one of the `` '' poorest '' '' substrates examined for all class i isoenzymes which are the predominant forms of the human enzyme . | NA | {
"id": "C0022173",
"name": "i isoenzym",
"pos": [
86,
96
]
} | {
"id": "C0014442",
"name": "enzy",
"pos": [
91,
95
]
} |
thus , incubation with albumin reduces the free fatty acid content of synaptosomal preparations , suggesting that the stimulatory effects of the proteins are related to their removal of inhibitory fatty acids formed by hydrolysis of membrane lipids during incubation . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
23,
30
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
145,
153
]
} |
thus , incubation with albumin reduces the free fatty acid content of synaptosomal preparations , suggesting that the stimulatory effects of the proteins are related to their removal of inhibitory fatty acids formed by hydrolysis of membrane lipids during incubation . | NA | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
43,
58
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
197,
208
]
} |
single-stranded dna , but not duplex dna or rna , inhibits dna relaxing activity , presumably by forming a covalent complex at the enzyme active site . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
0,
19
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
59,
62
]
} |
amino acid analysis indicates that glycine , alanine and leucine were present in elevated amounts , resulting in a polarity of 27 % . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
35,
42
]
} |
amino acid analysis indicates that glycine , alanine and leucine were present in elevated amounts , resulting in a polarity of 27 % . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
45,
52
]
} |
( 3 ) within a particular granule population , noradrenaline granules lyse at higher osmolarities than adrenaline granules , suggesting a higher core osmolarity of the noradrenaline granules . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
50,
60
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
168,
181
]
} |
the rate of the release of entrapped in-111 ions from the aqueous reservoir of small unilamellar liposomes or from the outermost aqueous compartment of multilamellar liposomes was used to monitor the rate of degradation of the exterior lipid bilayer surface of these liposomes . | NA | {
"id": "C1721091",
"name": "unilamellar",
"pos": [
85,
96
]
} | {
"id": "C0023828",
"name": "liposomes",
"pos": [
267,
276
]
} |
it was found that in the liver the exterior lipid bilayer of large multilamellar liposomes was degraded more rapidly than the bilayer of small unilamellar liposomes in vivo . | NA | {
"id": "C0023828",
"name": "liposomes",
"pos": [
81,
90
]
} | {
"id": "C1721091",
"name": "unilamellar liposomes",
"pos": [
143,
164
]
} |
in contrast to the situation for small unilamellar liposomes , the degradative process for large multilamellar liposomes in the liver was not maintained under ischemic conditions . | NA | {
"id": "C1721091",
"name": "unilamellar liposomes",
"pos": [
39,
60
]
} | {
"id": "C0023828",
"name": "liposomes",
"pos": [
111,
120
]
} |
to determine the molecular mechanism by which protein kinase-dependent phosphorylation regulates the calcium pump in skeletal sarcoplasmic reticulum , we examined the effects of protein kinase on the individual steps of the ca2+-atpase reaction sequence . | NA | {
"id": "C0916181",
"name": "calcium pump",
"pos": [
101,
113
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
224,
227
]
} |
the activity of calcium-stimulated and magnesium-dependent adenosinetriphosphatase which possesses a high affinity for free calcium ( high-affinity ( ca2+ + mg2+ ) -atpase , ec 3.6.1.3 ) has been detected in rat ascites hepatoma ah109a cell plasma membranes . | NA | {
"id": "C0001477",
"name": "magnesium",
"pos": [
39,
48
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
165,
171
]
} |
since the kinetic properties of the high-affinity ( ca2+ + mg2+ ) -atpase showed a close resemblance to those of erythrocyte plasma membrane ( ca2+ + mg2+ ) -atpase , the high-affinity ( ca2+ + mg2+ ) -atpase of rat ascites hepatoma cell plasma membrane is proposed to be a calcium-pumping atpase of these cells . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
67,
73
]
} | {
"id": "C0001476",
"name": "calcium",
"pos": [
274,
281
]
} |
( na+ + k+ ) -atpase and potassium phosphatase remained fully active in the detergent solution at c12e8/protein ratios of 2.5-3 , at which 50-70 % of the membrane protein was solubilized . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
104,
111
]
} | {
"id": "C0025252",
"name": "membrane",
"pos": [
154,
162
]
} |
it is found that the osmotic response of the ghosts to sucrose is about the same as that to raffinose , and the response to the smaller carbohydrates simply follows the number of carbons in various sugars ; | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
55,
62
]
} | {
"id": "C0242209",
"name": "sugars",
"pos": [
198,
204
]
} |
no other nucleic acids , including transfer rna ( trna ) and microsomal rna from normal as well as ethionine-treated rat livers , trna from escherichia coli , yeast rna , and dna from rat liver and calf thymus , were significantly methylated by this methylase . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
9,
22
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
175,
178
]
} |
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