text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
no other nucleic acids , including transfer rna ( trna ) and microsomal rna from normal as well as ethionine-treated rat livers , trna from escherichia coli , yeast rna , and dna from rat liver and calf thymus , were significantly methylated by this methylase . | NA | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
35,
47
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
165,
168
]
} |
moreover , restriction enzyme analysis of the 5,7-dimethoxycoumarin-dna photoadduct versus unmodified viral dna , suggested that the sequence d ( a-t ) is the preferential site for intercalation and subsequent photobinding of 5,7-dimethoxycoumarin . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
68,
71
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
102,
111
]
} |
when the anionic subsite of the phosphorylated or carbamylated enzyme was alkylated with an aziridinium ion , the reaction velocity toward indophenyl acetate increased in the phosphorylated enzyme but not in the carbamylated enzyme . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
9,
16
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
119,
122
]
} |
the plasminogen activator species used were high molecular weight urokinase , streptokinase , human glu-plasminogen-streptokinase complex , human plasmin-derived light ( b ) -chain-streptokinase complex , and the equimolar streptokinase activator complexes prepared from cat and dog plasmins . | NA | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
4,
25
]
} | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
223,
236
]
} |
the binding activity is promoted to ph 4 using carbonate or bicarbonate as synergistic anion . | NA | {
"id": "C0007026",
"name": "carbonate",
"pos": [
47,
56
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
60,
71
]
} |
the sugar contents of fiia and fiib were about 20.5 % and 8.7 % by weight , respectively , consisting of galactose , mannose , fucose and amino sugar . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
4,
9
]
} | {
"id": "C0002531",
"name": "amino sugar",
"pos": [
138,
149
]
} |
all three purified forms of the enzyme , as well as crude extracts of normal and isozyme i-deficient chinese livers , showed positive immunoreactivity to antibodies prepared in rabbits against type i enzyme . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
81,
88
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
200,
206
]
} |
the anions of the lyotropic series markedly influenced the reactivation , showing an effectiveness opposite to their salting-out potential ( thiocyanate congruent to iodide greater than chloride greater than phosphate congruent to sulphate congruent to citrate ) . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
4,
10
]
} | {
"id": "C0021966",
"name": "iodide",
"pos": [
166,
172
]
} |
the anions of the lyotropic series markedly influenced the reactivation , showing an effectiveness opposite to their salting-out potential ( thiocyanate congruent to iodide greater than chloride greater than phosphate congruent to sulphate congruent to citrate ) . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
4,
10
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
186,
194
]
} |
the anions of the lyotropic series markedly influenced the reactivation , showing an effectiveness opposite to their salting-out potential ( thiocyanate congruent to iodide greater than chloride greater than phosphate congruent to sulphate congruent to citrate ) . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
4,
10
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
208,
217
]
} |
the anions of the lyotropic series markedly influenced the reactivation , showing an effectiveness opposite to their salting-out potential ( thiocyanate congruent to iodide greater than chloride greater than phosphate congruent to sulphate congruent to citrate ) . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
4,
10
]
} | {
"id": "C0038720",
"name": "sulphate",
"pos": [
231,
239
]
} |
apolipoprotein b , the major structural protein of triacylglycerol-rich lipoprotein , occurs in two immunologically distinct forms , termed apolipoproteins b-100 and b-48 . | NA | {
"id": "C0003593",
"name": "apolipoprotein b",
"pos": [
0,
16
]
} | {
"id": "C0205666",
"name": "apolipoproteins b-100",
"pos": [
140,
161
]
} |
eicosapentaenoic acid ( 20:5 ) was preferentially released by phospholipase a2 , but the percentage of docosahexaenoic acid ( 22:6 ) in the free fatty acids was similar to the percentage in membrane total fatty acids . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
140,
156
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
205,
216
]
} |
the amino acid analysis revealed a high content of glutamic acid ( including glutamine ) and glycine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
93,
100
]
} |
the amino acid analysis revealed a high content of glutamic acid ( including glutamine ) and glycine . | NA | {
"id": "C0061472",
"name": "glutamic",
"pos": [
51,
59
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
77,
86
]
} |
the enzyme isolated by this procedure was free of apolipoprotein d , as shown by the absence of an arc in immunodiffusion with anti-apolipoprotein d . | NA | {
"id": "C0052193",
"name": "apolipoprotein d",
"pos": [
50,
66
]
} | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
132,
146
]
} |
the content of glycosaminoglycan in the tissue is low ( 0.05 % dry weight ) being comprised of dermatan sulphate ( 38 % ) , heparin ( 34 % ) , heparan sulphate ( 18 % ) and chondroitin sulphates ( 10 % ) as a percentage of total glycosaminoglycan content . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
124,
131
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
229,
246
]
} |
the content of glycosaminoglycan in the tissue is low ( 0.05 % dry weight ) being comprised of dermatan sulphate ( 38 % ) , heparin ( 34 % ) , heparan sulphate ( 18 % ) and chondroitin sulphates ( 10 % ) as a percentage of total glycosaminoglycan content . | NA | {
"id": "C0019143",
"name": "heparan",
"pos": [
143,
150
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
229,
246
]
} |
these findings suggest that prostaglandin e1 , e2 , and d2 increase the synthesis of cyclic amp and that the combined effect of the prostaglandins and pth on the cyclic amp level in chondrocytes is partly attributed to the synergistic synthesis of cyclic amp in the cells . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
182,
194
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
266,
271
]
} |
rats fed the same diet and given 20 mg iron intraperitoneally as iron-dextran ( imferon ) served as controls . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
39,
43
]
} | {
"id": "C0022092",
"name": "iron-dextran",
"pos": [
65,
77
]
} |
these sites possess high affinity to gdp ( kd less than 10 ( -6 ) m ) in dark-adapted preparations , and in the presence of bleached rhodopsin they effectively bind the non-hydrolizable analog of gtp -- gpp ( nh ) p ( kd less than 10 ( -6 ) m ) . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
196,
199
]
} | {
"id": "C0018366",
"name": "gpp",
"pos": [
203,
206
]
} |
influence of two cell harvesting methods on intracellular atp and amino acid concentrations in human fibroblast cultures . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
17,
21
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
101,
111
]
} |
the boys obtained higher type a scores and excreted more adrenaline and noradrenaline than the girls , while cortisol excretion did not differ between the sexes . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
57,
67
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
72,
85
]
} |
initial experiments established that bolus injection of dopamine hcl into cannulated ( left carotid ) rats pretreated with alpha-methyl-p -tyrosine ( mpt ) resulted in an appropriate reduction of serum prl and that the mpt treatment did not significantly alter testosterone or luteinizing hormone ( lh ) . | NA | {
"id": "C0051427",
"name": "alpha-methyl-p",
"pos": [
123,
137
]
} | {
"id": "C0886584",
"name": "mpt",
"pos": [
219,
222
]
} |
the daily excretion pattern of most of the major steroid metabolites was fairly consistent from day to day ( i.e . 3 alpha-hydroxy-5 alpha-androstane-17-one , androsterone ; 3 alpha-hydroxy-5 beta-androstane-17-one , etiocheolanolone ; 3 alpha , 17 alpha , 21-trihydroxy-5 beta-pregnane-11,20-dione , the ; 3 alpha , 11 ... | NA | {
"id": "C0033006",
"name": "pregnane",
"pos": [
278,
286
]
} | {
"id": "C0038317",
"name": "steroid",
"pos": [
821,
828
]
} |
negative ion mass spectra obtained by fast atom bombardment of glycerol solutions of steroid sulphates include the steroid sulphate anion as the single prominent feature . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
9,
12
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
132,
137
]
} |
negative ion mass spectra obtained by fast atom bombardment of glycerol solutions of steroid sulphates include the steroid sulphate anion as the single prominent feature . | NA | {
"id": "C0038720",
"name": "sulphates",
"pos": [
93,
102
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
132,
137
]
} |
the main classes of human plasma lipids , free fatty acids , cholesterol , cholesterol esters , triglycerides and phosphatidylcholines were identified and quantified from samples of human plasma by field desorption mass spectrometry . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
61,
72
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
75,
93
]
} |
within the classes of free fatty acids , triglycerides and phosphatidylcholines the fatty acid profile was obtained directly from the mass spectrum and accurate quantification could be achieved by the addition of stable isotope labelled internal standards . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
22,
38
]
} | {
"id": "C0015684",
"name": "fatty",
"pos": [
84,
89
]
} |
in these children , prekallikrein , kallikrein and kallikrein inhibitor were determined at a time by the 3 methods ( esterase , test-tube chromatographic and kininogenase ones ) . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
20,
33
]
} | {
"id": "C0022478",
"name": "kininogenase",
"pos": [
158,
170
]
} |
the esterase technique characterizes total factors of contact activation and does not reflect the activity of kallikrein , prekallikrein and kallikrein inhibitor . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
123,
136
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
141,
151
]
} |
the test-tube chromatographic method might be regarded as objective only in the measurement of the kininogenase activity of the fractions that contain kallikrein or prekallikrein . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
151,
161
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
165,
178
]
} |
heating of blood plasma acidified to ph 3.0 for 15-20 min at 61 degrees c allows for the conditions under which the kallikrein inhibitors ( alpha 1-antitrypsin , alpha 2-macroglobulin ) are destroyed whereas kallikrein , prekallikrein , low- and high-molecular kininogens ( hmk ) are preserved , thus constituting a comp... | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
221,
234
]
} | {
"id": "C0022478",
"name": "kininogenase",
"pos": [
347,
359
]
} |
a 70 % - and a greater decrease in the kallikrein content attests to the kininogenesis reduction because of the diminished levels of hmk , prekallikrein and kallikrein . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
139,
152
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
157,
167
]
} |
it has been found in experiments on rats trained to avoid electric stimulation of the foots by pressing the pedal that previous immobilization and administration of adrenaline and isoprenaline ( but not noradrenaline ) disturbs the accuracy of the realization of motor components of operant behavior . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
165,
175
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
203,
216
]
} |
it has been demonstrated in experiments on 134 cats that during acute blood loss ( 24 +/- 0.8 ml/kg ) , hyperbaric oxygen therapy ( 3039 hpa , 60 min ) stimulates cytochrome oxidase , eliminates compensatory activation of mitochondrial creatine kinase and maintains the hyperactivity of cytoplasmic creatine kinase in th... | NA | {
"id": "C0914594",
"name": "mitochondrial creatine",
"pos": [
222,
244
]
} | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
299,
314
]
} |
the authors studied the changes in the quantity and intensity of adrenergic nerve fiber fluorescence in the rat and human brain arteries every two hours after death at varying temperatures of keeping cadavers ( 18-20 , 10 , 4 degrees c ) . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
159,
164
]
} | {
"id": "C0006629",
"name": "cadavers",
"pos": [
200,
208
]
} |
7 tamoxifen did not alter oestrogen-induced changes in uterine weight , food consumption and body weight . | NA | {
"id": "C0005911",
"name": "changes in",
"pos": [
44,
54
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
93,
104
]
} |
the effects of different doses of nifedipine on frequency of angina and objective measurements of myocardial ischaemia during exercise were studied in 10 patients with stable angina pectoris . | NA | {
"id": "C0002962",
"name": "angina",
"pos": [
61,
67
]
} | {
"id": "C0340288",
"name": "stable angina pectoris",
"pos": [
168,
190
]
} |
fluidity , unesterified cholesterol content , and the ratio of cholesterol to phospholipid were unrelated to serum cholesterol and to low density lipoprotein cholesterol concentrations . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
24,
35
]
} | {
"id": "C0023824",
"name": "low density lipoprotein",
"pos": [
134,
157
]
} |
among patients with untreated early syphilis the antibodies detected by the tha test usually appeared later or were of relatively lower titre than those detected by the reagin tests . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
49,
59
]
} | {
"id": "C0034761",
"name": "reagin",
"pos": [
169,
175
]
} |
concomitant with this improvement in callosal function , the apraxia changed from ideational ( loss of the concept of skilled movements ) to classic ideomotor apraxia . | NA | {
"id": "C0003635",
"name": "apraxia",
"pos": [
61,
68
]
} | {
"id": "C0234523",
"name": "classic",
"pos": [
141,
148
]
} |
since l-dopa and naxolone can alleviate hypotension , we also studied the effects of these agents on orthostatic hypotension . | NA | {
"id": "C0020649",
"name": "hypotension",
"pos": [
40,
51
]
} | {
"id": "C0020651",
"name": "orthostatic hypotension",
"pos": [
101,
124
]
} |
calmodulin , gtp , guanyl 5'-yl imidodiphosphate ( gpp ( nh ) p ) and forskolin did not change the inhibition , but activities stimulated by naf or mn2+ were more resistant for the inhibition . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
13,
16
]
} | {
"id": "C0018366",
"name": "gpp",
"pos": [
51,
54
]
} |
l-glutamine at the concentration present in cerebrospinal fluid decreases the steady-state accumulation of the aromatic amino acids tryptophan , tyrosine and dihydroxyphenylalanine ( dopa ) in rat striatal synaptosomes . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
111,
131
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
132,
142
]
} |
l-glutamine at the concentration present in cerebrospinal fluid decreases the steady-state accumulation of the aromatic amino acids tryptophan , tyrosine and dihydroxyphenylalanine ( dopa ) in rat striatal synaptosomes . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
111,
131
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
145,
153
]
} |
spinal cord slices of control and eae rats were incubated with [ 3h ] amino acids , then cytoskeletal proteins were prepared in an enriched fraction , separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis ( sds-page ) , and the protein bands counted for radioactivity . | NA | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
89,
110
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
245,
252
]
} |
angiotensins with biological activity in the brain , i.e. , angiotensins i , ii , iii , and the fragments ( 3-8 ) and ( 4-8 ) competed with 3h-angiotensin ii for the binding sites with ic50 's of 9 x 10 ( -8 ) m , 2 x 10 ( -9 ) m , 4 x 10 ( -9 ) m , 4 x 10 ( -7 ) m and 4 x 10 ( -6 ) , respectively . | NA | {
"id": "C0003018",
"name": "angiotensins",
"pos": [
0,
12
]
} | {
"id": "C0003006",
"name": "angiotensins i",
"pos": [
60,
74
]
} |
the rer in these dwarf chondrocytes was not oriented parallel to the long axis of the cells ; | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
23,
35
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
86,
91
]
} |
these observations are consistent with previous studies indicating that the accumulation of phosphatidylcholine and dipalmitoyl phosphatidylcholine during the perinatal period may be due to alterations in the activity of cholinephosphate cytidylyltransferase . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
92,
111
]
} | {
"id": "C0000039",
"name": "dipalmitoyl",
"pos": [
116,
127
]
} |
enzymes of guanine nucleotide metabolism and the diurnal cycle in cgmp content of the chick pineal gland . | NA | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
11,
29
]
} | {
"id": "C0018338",
"name": "cycle",
"pos": [
57,
62
]
} |
however , it seems improbable that changes in pineal content of enzymes of guanine nucleotide metabolism are essential to regulation of diurnal cycles in cgmp content or level of nat activity . | NA | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
75,
93
]
} | {
"id": "C0018338",
"name": "cgmp",
"pos": [
154,
158
]
} |
whereas the lectin treated with reagent 2c was active as the unmodified protein , the lectin treated with compound 1c was more active than unmodified lectin at nearly all the concentrations tested . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
72,
79
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
150,
156
]
} |
the ultrastructural findings showed similarity to normal sertoli cells , pure sertoli cell tumors , sertoli cells in azoospermic human testes , and the sertoli cell component of sertoli-leydig cell tumors . | NA | {
"id": "C0036769",
"name": "sertoli cell tumors",
"pos": [
78,
97
]
} | {
"id": "C0206723",
"name": "sertoli cell",
"pos": [
152,
164
]
} |
one hundred and twenty-eight patients bearing primary malignancies of the large bowel were studied to ascertain the value of acute-phase reactant proteins ( serum protein hexose , ceruloplasmin , transferrin , alpha-1-antitrypsin , seromucoid and haptoglobin ) either alone or in conjunction with carcinoembryonic antige... | NA | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
125,
145
]
} | {
"id": "C0007841",
"name": "ceruloplasmin",
"pos": [
180,
193
]
} |
one hundred and twenty-eight patients bearing primary malignancies of the large bowel were studied to ascertain the value of acute-phase reactant proteins ( serum protein hexose , ceruloplasmin , transferrin , alpha-1-antitrypsin , seromucoid and haptoglobin ) either alone or in conjunction with carcinoembryonic antige... | NA | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
125,
145
]
} | {
"id": "C0040679",
"name": "transferrin",
"pos": [
196,
207
]
} |
one hundred and twenty-eight patients bearing primary malignancies of the large bowel were studied to ascertain the value of acute-phase reactant proteins ( serum protein hexose , ceruloplasmin , transferrin , alpha-1-antitrypsin , seromucoid and haptoglobin ) either alone or in conjunction with carcinoembryonic antige... | NA | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
125,
145
]
} | {
"id": "C0002191",
"name": "alpha-1-antitrypsin",
"pos": [
210,
229
]
} |
one hundred and twenty-eight patients bearing primary malignancies of the large bowel were studied to ascertain the value of acute-phase reactant proteins ( serum protein hexose , ceruloplasmin , transferrin , alpha-1-antitrypsin , seromucoid and haptoglobin ) either alone or in conjunction with carcinoembryonic antige... | NA | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
125,
145
]
} | {
"id": "C0029297",
"name": "seromucoid",
"pos": [
232,
242
]
} |
one hundred and twenty-eight patients bearing primary malignancies of the large bowel were studied to ascertain the value of acute-phase reactant proteins ( serum protein hexose , ceruloplasmin , transferrin , alpha-1-antitrypsin , seromucoid and haptoglobin ) either alone or in conjunction with carcinoembryonic antige... | NA | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
125,
145
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
247,
258
]
} |
the characteristics of hematin uptake were examined in three malignant cell lines [ l1210 leukemia , 745 murine erythroleukemia ( mel ) and walker carcinoma ( w256 ) ] , a cell line derived from normal rat liver ( brl-3a ) and a normal embryonic cell , chick embryo fibroblasts ( cef ) . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
195,
201
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
266,
277
]
} |
the karyotypic abnormalities , as observed in the bs lines have not been seen in the cells of any established normal b-lymphoid lines transformed by ebv and strongly suggest that the chromosome abnormalities in the bs -- b-cell lines with abnormal karyotypes originated in vivo and not through an in vitro effect of ebv ... | NA | {
"id": "C0008626",
"name": "chromosome abnormalities",
"pos": [
183,
207
]
} | {
"id": "C0476431",
"name": "abnormal",
"pos": [
239,
247
]
} |
when the cells were treated with increasing doses of doxorubicin or daunorubicin a decrease of the dna repair synthesis was recorded . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
53,
64
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
68,
80
]
} |
daunorubicin had a significantly higher inhibitory effect on the dna repair synthesis compared to doxorubicin . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
0,
12
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
98,
109
]
} |
the inhibitory effect by doxorubicin or daunorubicin on nitrogen mustard induced dna repair synthesis was compared with the inhibitory effect on replicative dna and rna synthesis in human lymphoblasts . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
25,
36
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
40,
52
]
} |
concurrent treatment with dfmo depressed putrescine content ( 42 to 63 % ) and spermidine content ( 27 to 38 % ) , but it increased spermine content ( 18 to 22 % ) . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
41,
51
]
} | {
"id": "C0037871",
"name": "content",
"pos": [
141,
148
]
} |
concurrent treatment with dfmo depressed putrescine content ( 42 to 63 % ) and spermidine content ( 27 to 38 % ) , but it increased spermine content ( 18 to 22 % ) . | NA | {
"id": "C0037871",
"name": "content",
"pos": [
52,
59
]
} | {
"id": "C0037874",
"name": "content",
"pos": [
141,
148
]
} |
the cytotoxic efficacies of several substituted anthraquinones , ametantrone , dihydroxyanthracenedione , dihydroxyanthracenedione diacetate , mitoxantrone , bisantrene , and doxorubicin , were evaluated on an established human colon adenocarcinoma cell line by the method of inhibition of colony formation . | NA | {
"id": "C0003174",
"name": "anthraquinones",
"pos": [
48,
62
]
} | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
143,
155
]
} |
at concentrations below 1 microgram/ml , mitoxantrone was about twice as active as both hydroxyl-substituted anthracenediones and doxorubicin , about 14 times more efficacious than ametantrone , and about 22 times more powerful than bisantrene . | NA | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
41,
53
]
} | {
"id": "C0003174",
"name": "anthracenediones",
"pos": [
109,
125
]
} |
of the total 3h radioactivities of glycosaminoglycans in fraction i from bhk cells , 51 % were in dermatan sulfate , 23 % were in heparan sulfate , 17 % were in chondroitin 4- and 6-sulfates , and 9 % were in hyaluronate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
35,
53
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
130,
145
]
} |
of the total 3h radioactivities of glycosaminoglycans in fraction i from bhk cells , 51 % were in dermatan sulfate , 23 % were in heparan sulfate , 17 % were in chondroitin 4- and 6-sulfates , and 9 % were in hyaluronate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
35,
53
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
161,
172
]
} |
of the total 3h radioactivities of glycosaminoglycans in fraction i from bhk cells , 51 % were in dermatan sulfate , 23 % were in heparan sulfate , 17 % were in chondroitin 4- and 6-sulfates , and 9 % were in hyaluronate . | NA | {
"id": "C0011602",
"name": "dermatan sulfate",
"pos": [
98,
114
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
161,
172
]
} |
within the central nervous system , gmem was expressed in 10 of 11 glioblastomas but was undetected in 5 of 6 astrocytomas and in normal adult and fetal brain by peroxidase-antiperoxidase immunohistology . | NA | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
67,
80
]
} | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
110,
122
]
} |
moab 244-19a , an immunoglobulin g2b , bound to msc cells and did not bind to two other sarcomas ( k-balb and ha2 ) , a carcinoma ( line 1 ) , a fibroblast ( a31 ) or a fibroblast infected with c-type virus ( a31-moloney leukemia virus ) . | NA | {
"id": "C0007634",
"name": "msc",
"pos": [
48,
51
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
169,
179
]
} |
in contrast , moab 271-1a bound to the msc and ha2 sarcoma and line 1 carcinoma as well as to the normal and infected fibroblast cultures . | NA | {
"id": "C0007634",
"name": "msc",
"pos": [
39,
42
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
118,
128
]
} |
effects of dna superhelical changes induced by ethidium bromide on the dna-degrading activity of two antitumor antibiotics , bleomycin and phleomycin . | NA | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
125,
134
]
} | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
139,
149
]
} |
the retinoic acid-resistant mutants exhibited cross-resistance to related retinoids such as 13-cis-retinoic acid and all-trans-retinol as well as to the arotinoid p- [ ( e ) -2- ( 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl ) propenyl ] benzoic acid suggesting that they all share a similar mechanism of action . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
74,
83
]
} | {
"id": "C0022265",
"name": "13-cis-retinoic acid",
"pos": [
92,
112
]
} |
effects of liposome dose and the presence of lymphosarcoma cells on blood clearance and tissue distribution of large unilamellar liposomes in mice . | NA | {
"id": "C0023828",
"name": "liposome",
"pos": [
11,
19
]
} | {
"id": "C1721091",
"name": "unilamellar liposomes",
"pos": [
117,
138
]
} |
the influence of intestinal microflora on the hepatotoxic effects of dimethylnitrosamine ( dmn ) or dimethylamine ( dma ) plus nano2 was studied by comparing the degree of liver necrosis and the levels of serum alanine aminotransferase ( gpt ) and aspartate aminotransferase ( got ) in germ-free and conventional male wi... | NA | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
219,
235
]
} | {
"id": "C0004002",
"name": "aspartate aminotransferase",
"pos": [
248,
274
]
} |
monoclonal antibodies to human melanoma-associated antigens : an amplified enzyme-linked immunosorbent assay for the detection of antigen , antibody , and immune complexes . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
140,
148
]
} |
monoclonal antibodies to human melanoma-associated antigens : an amplified enzyme-linked immunosorbent assay for the detection of antigen , antibody , and immune complexes . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
140,
148
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
155,
171
]
} |
administration of 2 % aqueous alpha-difluoromethylornithine ( dfmo ) as the sole drinking-fluid to c57bl x dba/2 f1 ( hereafter called bd2f1 ) mice for 5 days resulted in significant reduction of labeling index , percentage of cells in s phase , and intracellular putrescine and spermidine concentrations of bone marrow ... | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
264,
274
]
} | {
"id": "C0037871",
"name": "concentrations",
"pos": [
290,
304
]
} |
in animals inoculated i.p . with l1210 cells , dfmo treatment produced a marginal increase in survival time and significant reductions in putrescine and spermidine concentrations of the tumor cells . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
138,
148
]
} | {
"id": "C0037871",
"name": "concentrations",
"pos": [
164,
178
]
} |
the ability of the phorbol ester tumor promoter 12-o-tetradecanoylphorbol- 13-acetate ( tpa ) to lead to the activation of cyclic adenosine 3':5'-monophosphate ( camp ) -dependent protein kinase was investigated in three cell lines . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
19,
32
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol",
"pos": [
48,
73
]
} |
analysis of reassociation kinetics of the 32p-tl-cdna with dna from asl-1 cells showed that the kinetics was indistinguishable from that obtained using a dna encoding a single-copy gene ( c mu ) . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
50,
53
]
} | {
"id": "C0000702",
"name": "a dna",
"pos": [
152,
157
]
} |
blood flow to rg-2 tumors seems unlikely to limit drug delivery any more than to normal brain , and the consistent levels from tumor to tumor and within individual tumors make the rg-2 model an excellent one with which to study drug delivery in experimental brain tumors . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
19,
25
]
} | {
"id": "C0027659",
"name": "experimental",
"pos": [
245,
257
]
} |
retrovirus is also not induced when melanoma cultures are treated with 5-iodo-2'-deoxyuridine or bromodeoxyuridine and cocultivated with susceptible cells . | NA | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
81,
93
]
} | {
"id": "C0006233",
"name": "bromodeoxyuridine",
"pos": [
97,
114
]
} |
the disappearance kinetics of adriamycin could adequately be described by a biexponential equation with an initial half-life of 8-min and a terminal half-life of 30 hr . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
18,
26
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
149,
158
]
} |
the activities of three principal enzymes engaged in the biosynthesis and degradation of poly ( adenosine diphosphate-ribose ) [ poly ( adp-ribose ) ] were examined in cell nuclei isolated from adenomatous polyps ( tubular adenomas of familial polyposis coli , villous adenoma , and tubulovillous adenoma ) , cancers , a... | NA | {
"id": "C0206677",
"name": "adenomatous polyps",
"pos": [
194,
212
]
} | {
"id": "C0032580",
"name": "familial polyposis coli",
"pos": [
235,
258
]
} |
analyses of reaction products with snake venom phosphodiesterase digestion revealed that poly ( adp-ribose ) synthesized in nuclei of normal mucosa , adenomatous polyps , and cancers had the average chain lengths of 2.9 , 1.7 , and 9.7 adp-ribose units , respectively . | NA | {
"id": "C0032403",
"name": "poly ( adp-ribose",
"pos": [
89,
106
]
} | {
"id": "C0001461",
"name": "adp-ribose",
"pos": [
236,
246
]
} |
based upon these values and total amounts of adp-ribose incorporated , the amount of poly ( adp-ribose ) synthesized per mg dna in 30 min was calculated as 308 , 1510 , and 106 pmol in the above three types of colon tissues , respectively . | NA | {
"id": "C0001461",
"name": "adp-ribose",
"pos": [
45,
55
]
} | {
"id": "C0032403",
"name": "poly ( adp-ribose",
"pos": [
85,
102
]
} |
we monitored the levels in plasma and urine of adenosine , 2'-deoxyadenosine , and ara-a as well as the accumulation of their nucleotide derivatives in erythrocytes and circulating lymphoblasts . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
47,
56
]
} | {
"id": "C0042646",
"name": "ara-a",
"pos": [
83,
88
]
} |
an increase is associated with a reduced susceptibility to epileptogenic agents but not with the prevention of epilepsy , while a decrease may precipitate seizure activity in genetically susceptible rats but does not bring about spontaneous epileptic activity in normal animals . | NA | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
41,
55
]
} | {
"id": "C0314657",
"name": "genetically susceptible",
"pos": [
175,
198
]
} |
mitoxantrone is a synthetic anthraquinone that was developed through the doxorubicin analog program in hopes of retaining anticancer activity with less cardiotoxicity . | NA | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
0,
12
]
} | {
"id": "C0003174",
"name": "anthraquinone",
"pos": [
28,
41
]
} |
however , 4'-epi-doxorubicin has greater antitumor activity than doxorubicin in lewis lung carcinoma , ms-2 sarcoma lung metastasis , and human melanoma in athymic mice . | NA | {
"id": "C0014582",
"name": "4",
"pos": [
10,
11
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
65,
76
]
} |
the hepatobiliary metabolism and excretion of 4'-epi-dx investigated in the rat , indicated that the new analogue was more extensively metabolized than the parent compound . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
18,
28
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
33,
42
]
} |
specific and comparative studies are in progress : preliminary findings from a randomized comparison of 4'-epi-dx vs dx in breast cancer indicated that 4'-epi-dx may have a lower cumulative cardiotoxicity . | NA | {
"id": "C0013089",
"name": "dx",
"pos": [
111,
113
]
} | {
"id": "C0014582",
"name": "4",
"pos": [
152,
153
]
} |
haemophilus influenzae type b capsular polysaccharide [ repeating unit , leads to 3 ) -beta-d-ribf- ( 1 leads to 1 ) -d-ribol-5- ( po2h leads to ] was partially hydrolyzed with hcl to give oligosaccharides that were isolated by size-exclusion chromatography , and then characterized by 31p- and 13c-n.m.r.-spectral and c... | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
39,
53
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
189,
205
]
} |
on graded hydrolysis and smith degradation , the o-somatic polysaccharide isolated from shigella dysenteriae type 9 bacteria , strain nctc 7919 , yielded five oligosaccharides which were characterized . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
59,
73
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
159,
175
]
} |
binding of polyphosphates and phosphonates to hydroxyapatite , subsequent hydrolysis , phosphate exchange and effects on demineralization , mineralization and microcrystal aggregation . | NA | {
"id": "C0032575",
"name": "polyphosphates",
"pos": [
11,
25
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
87,
96
]
} |
quantitative determinations of catecholamines ( ca ) by high-performance liquid chromatography and electrochemical detection ( hplc-ed ) revealed 15.4 +/- 3.3 ng/mg protein of norepinephrine ( ne ) and 3.14 ng/mg protein of epinephrine ( e ) , with even larger amounts in the cranial part of the ovary close to the adren... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
176,
190
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
224,
235
]
} |
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