text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the plant lectin , concanavalin a ( con a ) suppresses milk secretion when infused into the mammary gland or when incubated with lactating tissue in vitro . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
4,
16
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
19,
33
]
} |
preliminary observations of satellite cells in undamaged fibres of the rat soleus muscle assaulted by a snake-venom toxin . | NA | {
"id": "C0037380",
"name": "snake",
"pos": [
104,
109
]
} | {
"id": "C0042479",
"name": "venom",
"pos": [
110,
115
]
} |
as no hybrid isoenzyme was detected , it is not known whether these cells which had moved into the regenerating minced grafts were muscle precursors , fibroblasts or some other cell types . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
68,
73
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
151,
162
]
} |
immunocytochemical identification of thyrotropin ( tsh ) -producing cells in pituitary glands of several species of teleosts with antiserum to human tsh beta subunit . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
37,
48
]
} | {
"id": "C0076641",
"name": "tsh beta",
"pos": [
149,
157
]
} |
a rabbit antiserum raised against human thyrotropin ( tsh ) beta subunit ( anti-human beta-tsh ) was used to identify tsh cells in the pituitaries of five species of teleosts by means of the unlabeled antibody peroxidase-antiperoxidase ( pap ) technique . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
9,
18
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
201,
209
]
} |
a single-stranded dna nuclease activity and a double-stranded dna nuclease activity have been found in chick embryo fiber cells . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
2,
21
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
46,
65
]
} |
these results confirm that the suppression of myogenic functions previously observed in cell hybrids involving fibroblastoid tumor cells also occurs in heterokaryons isolated using biochemical inhibitors between diploid fibroblasts and chick skeletal myocytes . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
88,
92
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
220,
231
]
} |
a direct influence on t-cell protein synthesis by either colchicine or lumicolchicine is likely , as greater than or equal to 10 ( -6 ) m concentrations of alkaloid identically inhibited [ 3h ] leucine incorporation and fc mu-receptor expression by t cells without inhibiting their alpha-methyl isobutyric acid transport... | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
57,
67
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
156,
164
]
} |
immunoglobulin-containing cells of the iga isotype were examined by immunofluorescence of mononuclear cells isolated from the submandibular salivary glands and cervical lymph nodes after primary and multiple local injections of streptococcus mutans . | NA | {
"id": "C0020835",
"name": "immunoglobulin",
"pos": [
0,
14
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
43,
50
]
} |
the suppressive capacity was shown to reside in a cell population which was sensitive to treatment with monoclonal lyt-2.1 antibody and complement but not with lyt-1.1 antibody . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
104,
114
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
168,
176
]
} |
lysis of surface-idiotype-positive hybridoma cells was effected by mouse spleen cells , mouse peritoneal cells , or human blood mononuclear cells , in the presence of anti-idiotypic antibodies . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
45,
50
]
} | {
"id": "C1321301",
"name": "blood mononuclear cells",
"pos": [
122,
145
]
} |
recent investigations have indicated that the okm1 hybridoma monoclonal antibody reactive with cells of the myelomonocytic series identifies a subpopulation of human peripheral blood mononuclear cells ( pbmnc ) which mediate natural and antibody-dependent cellular cytotoxicity ( adcc ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
95,
100
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
166,
200
]
} |
using a monoclonal antibody specific for human fibronectin ( fn ) , we screened hybrid clones derived from the fusion of fn+ human fibroblasts , carrying a 11/x translocation , and fn- , hprt- mouse cells for the production of this glycoprotein . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
131,
142
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
199,
204
]
} |
these cells appeared different when compared with the classical fibroblasts encountered throughout the rest of the stromal endometrium . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
64,
75
]
} |
no significant differences in tumour incidence were observed between the groups of animals given the different types of dusts , but statistically significant differences were noted in survival times , according to the histological type of tumour . | NA | {
"id": "C0027651",
"name": "tumour",
"pos": [
30,
36
]
} | {
"id": "C0027652",
"name": "histological type of",
"pos": [
218,
238
]
} |
such modification strongly inhibits the template capacity of the polynucleotide and leads to an increase in non-complementary nucleotide incorporation . | NA | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
65,
79
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
126,
136
]
} |
preliminary findings show that the primitive reflex and postural adjustment assessment procedure can successfully identify degrees of neurodevelopmental delay in young children , and that the procedure differentiates normal children from mentally retarded and emotionally disturbed children . | NA | {
"id": "C0728836",
"name": "young",
"pos": [
162,
167
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
282,
290
]
} |
sr was incubated for 20 min at 37 degrees c in the presence of phorbol myristate acetate activated leukocytes ( a-l ) and calcium uptake and ca2+-adenosine triphosphatase ( atpase ) activities were measured . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
141,
144
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
173,
179
]
} |
the relationship between plasma norepinephrine ( ne ) , epinephrine ( e ) and dopamine-beta-hydroxylase activity ( dbh ) was studied in 90 cardiac patients ( new york heart association [ nyha ] classes i-iv ) , 85 healthy control subjects and 18 competitive skiers . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
32,
46
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
56,
67
]
} |
there was no deterioration of renal function , new or persistent increase in proteinuria , neutropenia or agranulocytosis acutely or during 17 +/- 2 weeks of follow-up . | NA | {
"id": "C0023530",
"name": "neutropenia",
"pos": [
91,
102
]
} | {
"id": "C0001824",
"name": "agranulocytosis",
"pos": [
106,
121
]
} |
in that study , timolol maleate reduced total mortality ( 152 placebo vs 98 timolol ) and the incidence of first nonfatal reinfarctions ( 131 placebo vs 90 timolol ) . | NA | {
"id": "C0087093",
"name": "timolol maleate",
"pos": [
16,
31
]
} | {
"id": "C0040233",
"name": "timolol",
"pos": [
156,
163
]
} |
the effects of propranolol on lipids and lipoproteins were investigated in survivors of a recent myocardial infarction who were enrolled in the double-blind beta-blocker heart attack trial . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
30,
36
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
41,
53
]
} |
thus , regional myocardial dysfunction reduced by nontransmural ischemia for 5 hr persisted for at least 3 days , with only slight damage to the left ventricular free wall but considerable infarction of the posterior papillary muscle . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
64,
72
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
189,
199
]
} |
23 had coronary artery disease ( ischemia group ) , five with prior infarction had an akinetic area at rest ( scar group ) , and five had minimal cardiovascular disease ( control ) . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
33,
41
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
68,
78
]
} |
the quantitation of fetal hemoglobin-containing cells is generally accomplished by the acid elution of adult hemoglobin and subsequent identification of cells positively stained for fetal hemoglobin by light microscopy . | NA | {
"id": "C0015936",
"name": "fetal hemoglobin",
"pos": [
20,
36
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
188,
198
]
} |
albumin and immunoglobulin g ( igg ) were determined in cerebrospinal fluid ( csf ) and serum , and the csf/serum albumin index ( csf x 10 ( 3 ) /serum albumin concentration ratio ) and igg index [ ( csf/serum igg ) / ( csf/serum albumin ) ] were calculated . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
0,
7
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
224,
237
]
} |
a 5-min optimized automated assay for measuring acetylcholinesterase ( ache ) and total cholinesterase ( che ) in amniotic fluids is described in which a centrifugal analyzer is used . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
48,
68
]
} | {
"id": "C0008429",
"name": "cholinesterase",
"pos": [
88,
102
]
} |
although with conventional enzymatic reagents for determination of serum total cholesterol the hydrolysis of the cholesterol esters may be incomplete , a new enzymatic cholesterol reagent ( monotest cholesterol , high performance , boehringer mannheim ) gives virtually complete cholesterol ester cleavage ( i.e. , great... | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
79,
90
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
279,
296
]
} |
two methods are described for circumventing this interference : adjusting the ph of the buffer and adding sodium dodecyl sulfate ( lauryl sulfate ) . | NA | {
"id": "C0037506",
"name": "sodium dodecyl sulfate",
"pos": [
106,
128
]
} | {
"id": "C0058632",
"name": "lauryl sulfate",
"pos": [
131,
145
]
} |
therefore , maximum levels for volatile halocarbons in drinking water should be sufficiently low to prevent these substances being detected in body fluids and special care should be taken with hospital water . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
55,
69
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
202,
207
]
} |
these enzymes include aminopeptidases , cathepsin c , angiotensin-converting enzyme , serine proteinase , sulphatase , phosphatase , esterases and ribonuclease . | NA | {
"id": "C0038717",
"name": "sulphatase",
"pos": [
106,
116
]
} | {
"id": "C0014894",
"name": "esterases",
"pos": [
133,
142
]
} |
there were iduronate sulfatase , arylsulfatase b , heparan sulfate ( hs ) sulfatase , n-acetylgalactosamine-6-sulfate sulfatase , hs-derived n-acetylglucosamine-6-sulfate sulfatase , and two keratan sulfate ( ks ) -derived n-acetylglucosamine-6-sulfate sulfatases . | NA | {
"id": "C0020814",
"name": "iduronate sulfatase",
"pos": [
11,
30
]
} | {
"id": "C0038717",
"name": "sulfatases",
"pos": [
253,
263
]
} |
a simple routine method is described for simultaneous assay of total urinary adrenaline , noradrenaline and dopamine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
77,
87
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
90,
103
]
} |
the normal range ( 95 % confidence level ) was 20-230 micrograms/24 h for noradrenaline and 1-35 micrograms/24 h for adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
74,
87
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
117,
127
]
} |
unreliability of enzymatic cholesterol analyses for the determination of electrophoretically separated lipoproteins : selective loss of hdl cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
27,
38
]
} | {
"id": "C0023822",
"name": "hdl cholesterol",
"pos": [
136,
151
]
} |
the albumin preparations were further purified and shown by physical and immunochemical techniques to be uncontaminated by other proteins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
4,
11
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
129,
137
]
} |
this seasonal variability should be taken into account in long-term studies involving adrenal hormone levels , excretion or metabolism . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
111,
120
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
124,
134
]
} |
the mean maximal concentrations of adrenaline ( 1.53 +/- 0.28 ng/ml v. 1.29 +/- 0.12 ng/ml ) and noradrenaline ( 0.56 +/- 0.16 ng/ml v. 0.45 +/- 0.04 ng/ml ) were not statistically different in the two groups . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
35,
45
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
97,
110
]
} |
in 40 male patients with essential hypertension less than the age of 36 years , the plasma prolactin ( prl ) , plasma renin activity ( pra ) and plasma catecholamines ( noradrenaline ( na ) and adrenaline ( a ) ) were determined simultaneously . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
169,
182
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
194,
204
]
} |
single cells were sorted from cultured fibroblasts of five carriers of fabry 's disease using a cell sorter ( facs ii ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
7,
12
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
39,
50
]
} |
the monoclonal antibody hnk-1 identifies a subpopulation of lymphocytes containing almost all of the natural killer ( nk ) and antibody-dependent killer ( k ) cell activity . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
4,
23
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
127,
135
]
} |
in one test of suppressor cell function con a incubated mitomycin treated pbm cells were added to autologous pbm cells stimulated with con a to compare the degree of suppression with that produced by control incubated mitomycin treated cells ( con a suppression test ) . | NA | {
"id": "C1321301",
"name": "pbm cells",
"pos": [
74,
83
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
236,
241
]
} |
to test the hypothesis that cell surface carbohydrate ( s ) might be involved in recognitive and/or lytic events , the binding and cytotoxicity of peripheral blood lymphocytes ( pbl ) towards nk sensitive k-562 targets was studied in the presence of simple sugars and after treatment of the targets with the antibiotic ,... | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
41,
53
]
} | {
"id": "C0026492",
"name": "simple sugars",
"pos": [
250,
263
]
} |
these data suggest that carbohydrates are not the target sites of nk recognition but that simple sugars may have an inhibitory action at a later stage of the lytic process . | NA | {
"id": "C0007004",
"name": "carbohydrates",
"pos": [
24,
37
]
} | {
"id": "C0026492",
"name": "simple sugars",
"pos": [
90,
103
]
} |
the prevalence of liver cell membrane antibodies ( lma ) was evaluated in the sera of 124 untreated patients with various chronic liver diseases , in 17 acute hepatitis patients and in 40 normal controls by indirect immunofluorescence on rabbit hepatocytes , isolated by non-enzymatic method . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
38,
48
]
} | {
"id": "C0004358",
"name": "lma",
"pos": [
51,
54
]
} |
the presence of lma was compared with the presence of hbs ag , anti-hbc and non-organ specific autoantibodies ( anti-nuclear antibody , ana ; smooth muscle antibody , sma ; anti-mitochondrial antibody , ama ; liver-kidney microsomal antibody , lkm ) . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
95,
109
]
} | {
"id": "C0003243",
"name": "anti-nuclear antibody",
"pos": [
112,
133
]
} |
rheumatoid factor , anti-nuclear and anti-mitochondrial autoantibodies were not detectable in patients ' sera by indirect immunofluorescence technique ( iif ) . | NA | {
"id": "C0035448",
"name": "rheumatoid",
"pos": [
0,
10
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
56,
70
]
} |
using a combined indirect immunoperoxidase ( pap ) /direct immunofluorescence ( if ) staining technique , pregnancy associated alpha 2-glycoprotein ( alpha 2-pag ) has been shown to be present solely in the iga producing plasma cells . alpha 2-pag was undetectable in plasma cells synthesizing any of the other immunoglo... | NA | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
311,
325
]
} | {
"id": "C0020843",
"name": "igd",
"pos": [
349,
352
]
} |
several neuropeptides should be involved in alzheimer 's disease : substance p , endorphins , vasopressin , acth , somatostatin , vasoactive intestinal peptide , cholecystokinin , neurotensin , delta sleep-inducing peptide . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
8,
21
]
} | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
180,
191
]
} |
several neuropeptides should be involved in alzheimer 's disease : substance p , endorphins , vasopressin , acth , somatostatin , vasoactive intestinal peptide , cholecystokinin , neurotensin , delta sleep-inducing peptide . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
8,
21
]
} | {
"id": "C0011228",
"name": "delta sleep-inducing peptide",
"pos": [
194,
222
]
} |
we have developed a combined in vivo/in vitro labeling procedure which is simple and rapid , and which enables the administration of substantial amounts of rbc-bound tc-99m and minimizes the amount of unbound technetium present . | NA | {
"id": "C0303611",
"name": "tc-99m",
"pos": [
166,
172
]
} | {
"id": "C0039411",
"name": "technetium",
"pos": [
209,
219
]
} |
the quantitative aspects of drug disposition in man of the commonly used antineoplastic agents , including cyclophosphamide , the nitrosoureas , cisplatin , methotrexate , cytarabine , 5-fluorouracil , doxorubicin , daunorubicin , bleomycin , vincristine , vinblastine , and vindesine are reviewed . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
202,
213
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
216,
228
]
} |
the most unique of the newer benzodiazepines are the ultra-short half-life ( oxidised ) compounds midazolam , triazolam and brotizolam , which are essentially non-accumulating during multiple dosage . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
29,
44
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
98,
107
]
} |
plasma concentrations ( measured fluorometrically ) , isoproterenol dose-response relationship ( to calculate the dose needed to increase heart rate by 25 bpm ) , renin , epinephrine , and norepinephrine were measured several times before and after the first and last dose . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
171,
182
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
189,
203
]
} |
after tcas , ne was increased by 51 +/- 6 % of basal values and heart rate rose , but epi and map were unchanged . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
13,
15
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
86,
89
]
} |
the combined use of these drugs may lead to a practical dyphylline dosage schedule in aminophylline-hypersensitive patients or those incapacitated by theophylline gastrointestinal side effects . | NA | {
"id": "C0013360",
"name": "dyphylline",
"pos": [
56,
66
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
150,
162
]
} |
the plasma contains a significantly reduced content of both cholesterol and phospholipid while the ratio of cholesteryl ester to total cholesterol , the distribution of phospholipid classes , triglyceride concentration and the fatty acid content were similar to normal values . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
60,
71
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
108,
125
]
} |
the extent of degradation in chicken chondrocytes was resistant to changes in temperature , whereas that in the ht-1080 cells was clearly increased when the incubation temperature was raised to 43 degrees c . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
37,
49
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
120,
125
]
} |
somatic cell hybrids between mouse cells and human normal skin and corneal fibroblasts and recessive dystrophic epidermolysis bullosa ( rdeb ) skin fibroblasts have been used to assign the structural gene for collagenase to its human chromosome . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
35,
40
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
148,
159
]
} |
the test toothpastes were : 1 ) a low abrasion paste containing 0.8 % sodium monofluorophosphate ( mfp ) , and 2 ) a paste containing 3 % sodium trimetaphosphate ( tmp ) . | NA | {
"id": "C0040462",
"name": "toothpastes",
"pos": [
9,
20
]
} | {
"id": "C1321899",
"name": "paste",
"pos": [
117,
122
]
} |
the marmoset showed antibodies against ebv capsid and early antigens ( vca , ea ) but not against nuclear antigen ( ebna ) . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
60,
68
]
} | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
98,
113
]
} |
the gt fluid 's free amino acid components showed reduced glycine and elevated valine and isoleucine in the heat-exposed group as compared with controls . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
21,
31
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
58,
65
]
} |
histone 5 stains metachromatically with coomassie blue r-250 , a property shared only with collagens and procollagens , histones 1 and 2b , and possibly certain proline-rich salivary gland proteins . | NA | {
"id": "C0009325",
"name": "collagens",
"pos": [
91,
100
]
} | {
"id": "C0033235",
"name": "procollagens",
"pos": [
105,
117
]
} |
there is an in vivo as well as in vitro fixation of free glucose by the albumen proteins . | NA | {
"id": "C0001924",
"name": "albumen",
"pos": [
72,
79
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
80,
88
]
} |
the effect of experimental anaemia on red cell gsh and enzyme activities of gsh-px , gssg-r and g6pd was investigated in guinea-pig and rabbit . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
47,
50
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
85,
89
]
} |
when the seizure is focal or the patient has perinatal difficulty , febrile convulsions should be treated carefully , as the possibility of epilepsy exists . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
9,
16
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
140,
148
]
} |
when the seizure is focal or the patient has perinatal difficulty , febrile convulsions should be treated carefully , as the possibility of epilepsy exists . | NA | {
"id": "C0009952",
"name": "febrile convulsions",
"pos": [
68,
87
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
140,
148
]
} |
to determine the incidence of patch test reactions to copper , 2 % copper sulphate was included in our routine patch test series . | NA | {
"id": "C0009968",
"name": "copper",
"pos": [
54,
60
]
} | {
"id": "C0056301",
"name": "copper sulphate",
"pos": [
67,
82
]
} |
in all blood samples the levels of immunoreactive lutropin ( lh ) , estradiol ( e2 ) , 17-hydroxyprogesterone ( 17-ho-p ) , progesterone ( p ) and 20 alpha-dihydroprogesterone ( 20 alpha-ho-p ) were estimated by radioimmunoassay . | NA | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
87,
109
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
163,
175
]
} |
in all blood samples the levels of immunoreactive lutropin ( lh ) , estradiol ( e2 ) , 17-hydroxyprogesterone ( 17-ho-p ) , progesterone ( p ) and 20 alpha-dihydroprogesterone ( 20 alpha-ho-p ) were estimated by radioimmunoassay . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
97,
109
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
147,
175
]
} |
this includes patients over 40 years of age , with chronic ulcerative colitis , familial multiple polyposis or gardner 's syndrome , family history of inherited cancer , and medical history of adenomatous polyps , colorectal cancer , or female genital cancer . | NA | {
"id": "C0032580",
"name": "familial",
"pos": [
80,
88
]
} | {
"id": "C0206677",
"name": "adenomatous polyps",
"pos": [
193,
211
]
} |
a ( g + c ) -rich satellite dna component ( p = 1.716 g/ml ) has been fractionated from the total dna of the iranian subspecies of the asiatic wild ass , equus hemionus onager , by successive dactinomycin-cscl and netropsin sulfate-cscl isopycnic gradients . | NA | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
18,
31
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
98,
101
]
} |
in spite of the failure of papain and other proteinases to release the endopeptidase from the membrane , reconstitution of the purified enzyme in liposomes has shown that it is a stalked dimeric protein , thus resembling other hydrolases in this membrane . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
44,
55
]
} | {
"id": "C0030946",
"name": "endopeptidase",
"pos": [
71,
84
]
} |
in spite of the failure of papain and other proteinases to release the endopeptidase from the membrane , reconstitution of the purified enzyme in liposomes has shown that it is a stalked dimeric protein , thus resembling other hydrolases in this membrane . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
44,
55
]
} | {
"id": "C0020289",
"name": "hydrolases",
"pos": [
227,
237
]
} |
an important but unresolved question concerns the relationships between transporter proteins in the membrane and proteins that have digestive functions ; | NA | {
"id": "C0007292",
"name": "transporter",
"pos": [
72,
83
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
113,
121
]
} |
structural changes have been studied during the life cycles of three glycosidases : sucrase-isomaltase ( ec 3.2.48-10 ) , lactase-phlorizin hydrolase ( ec 3.2.1.23-62 ) , maltase-glucoamylase ( ec 3.2.1.20 ) ; | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
69,
81
]
} | {
"id": "C0028941",
"name": "sucrase-isomaltase",
"pos": [
84,
102
]
} |
structural changes have been studied during the life cycles of three glycosidases : sucrase-isomaltase ( ec 3.2.48-10 ) , lactase-phlorizin hydrolase ( ec 3.2.1.23-62 ) , maltase-glucoamylase ( ec 3.2.1.20 ) ; | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
69,
81
]
} | {
"id": "C0020289",
"name": "ec 3",
"pos": [
194,
198
]
} |
hl-60 promyelocytic leukemic cells can differentiate into more mature myeloid cells with the addition of dimethylsulfoxide , butyric acid or retinoic acid and can differentiate into macrophages with the addition of phorbol ester 12-0-tetradecanoylphorbol-13-acetate ( tpa ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
215,
228
]
} | {
"id": "C0039654",
"name": "tetradecanoylphorbol",
"pos": [
234,
254
]
} |
in an attempt to differentiate the effect of fenfluramine hydrochloride from that of caloric restriction on carbohydrate tolerance in patients with lipodystrophy , parameters of carbohydrate homeostasis were studied in patients with lipodystrophy during periods of fenfluramine treatment and during periods of caloric re... | NA | {
"id": "C0282179",
"name": "fenfluramine hydrochloride",
"pos": [
45,
71
]
} | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
265,
277
]
} |
the plasma glucose , c-peptide , and insulin ( immunoreactive ) responses to human insulin and porcine insulin were identical in the studies with and without somatostatin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
37,
44
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
95,
110
]
} |
the area under the time-concentration curve ( auc ) of iri was slightly greater after s.c. injection of human insulin than after that of porcine insulin at the 0.05-u/kg dose level . | NA | {
"id": "C0021641",
"name": "iri",
"pos": [
55,
58
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
137,
152
]
} |
because no significant difference was observed in the plasma c-peptide level and no such difference was noticed in the auc of iri between the two insulins after i.v . injection , the bioavailability of human insulin seemed to be greater than that of porcine insulin after s.c. injection . | NA | {
"id": "C0021641",
"name": "iri",
"pos": [
126,
129
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
202,
215
]
} |
because no significant difference was observed in the plasma c-peptide level and no such difference was noticed in the auc of iri between the two insulins after i.v . injection , the bioavailability of human insulin seemed to be greater than that of porcine insulin after s.c. injection . | NA | {
"id": "C0021641",
"name": "iri",
"pos": [
126,
129
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
250,
265
]
} |
in insulin-dependent diabetic subjects , whose blood glucose levels were also held constant by feedback glucose infusion , the free insulin profiles after s.c. injection of neutral soluble human insulin and porcine insulin ( 0.2 u/kg ) were identical , and similar to those after conventional and highly purified bovine ... | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
3,
10
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
207,
222
]
} |
the usefulness of human insulin ( novo ) in the treatment of diabetes was studied in eight insulin-dependent diabetic patients . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
18,
31
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
91,
98
]
} |
employing the glucose-controlled insulin infusion system resulted in mean daily insulin requirements of 84 +/- 9 u and 85 +/- 6 u sem for porcine and human insulin , respectively ( p = ns ) . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
33,
40
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
150,
163
]
} |
the absorption of insulin after subcutaneous injection of human insulin ( actrapid , novo ) was significantly accelerated and its hypoglycemic effect significantly stronger when compared with porcine insulin ( actrapid ) . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
18,
25
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
192,
207
]
} |
the structure was first confirmed in 1982 by x-ray crystallography , in which complete overlaps of x-ray diffraction patterns were achieved on exposures of insulin from human pancreas and human insulin prepared from porcine insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
156,
163
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
188,
201
]
} |
the structure was first confirmed in 1982 by x-ray crystallography , in which complete overlaps of x-ray diffraction patterns were achieved on exposures of insulin from human pancreas and human insulin prepared from porcine insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
156,
163
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
216,
231
]
} |
additional complementary identity tests like hplc and immunochemical cross-reactivity with anti-insulin sera have substantiated the identity of insulin from human pancreas with human insulin prepared from porcine insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
96,
103
]
} | {
"id": "C0795635",
"name": "human",
"pos": [
177,
182
]
} |
additional complementary identity tests like hplc and immunochemical cross-reactivity with anti-insulin sera have substantiated the identity of insulin from human pancreas with human insulin prepared from porcine insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
96,
103
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
205,
220
]
} |
igg-insulin antibody titers were significantly lower in patients treated with human insulin compared with diabetic patients who received the corresponding pork mc insulin preparations from the onset of their disease . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
4,
11
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
78,
91
]
} |
although both insulin regimens resulted in similar plasma glucose profiles , values were lower during the night with porcine insulin treatment . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
14,
21
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
117,
132
]
} |
fifty-one insulin-dependent diabetic patients , 26 children and 25 adults , participated in an open uncontrolled study of the safety and efficacy of human insulin ( novo ) . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
10,
17
]
} | {
"id": "C0795635",
"name": "human",
"pos": [
149,
154
]
} |
the safety and efficacy of human insulin ( novo ) were evaluated in a double-blind , parallel , multicenter trial in which 47 insulin-dependent diabetic patients were randomly divided into two equal groups and treated with either purified pork or human insulin ( actrapid and monotard , novo ) for 12 wk . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
33,
40
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
247,
260
]
} |
we have investigated the binding of insulin-specific ige ( ige1 ) to porcine , bovine , and human insulin ( novo ) , pancreatic polypeptide , and a-component in serum samples from type i diabetic patients treated with insulin preparations of different purity . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
92,
105
]
} | {
"id": "C0021641",
"name": "insulin preparations",
"pos": [
218,
238
]
} |
species differences in the metabolic conjugation of clofibric acid and clofibrate in laboratory animals and man . | NA | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
52,
66
]
} | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
71,
81
]
} |
the urinary metabolites of single doses of clofibric acid ( p-chlorophenoxyisobutyric acid ) , and its ethyl ester , clofibrate , have been investigated in rat , guinea pig , rabbit , dog , cat , ferret , and human volunteers . | NA | {
"id": "C0009003",
"name": "p-chlorophenoxyisobutyric acid",
"pos": [
60,
90
]
} | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
117,
127
]
} |
interviews were conducted with 100 mothers of young children who also responded spontaneously to each of the eight situations just as they might respond to their own children . | NA | {
"id": "C0728836",
"name": "of young children",
"pos": [
43,
60
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
166,
174
]
} |
( c ) drugs enhancing serotoninergic neurotransmission ( e.g . the serotoninergic precursors tryptophan and 5-hydroxytryptophan , direct-acting serotonin agonists such as quipazine and mk 212 , and indirect-acting serotonin agonists such as fenfluramine ) ; | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
93,
103
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
108,
127
]
} |
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