text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
human gastrin ( i ) , pentagastrin , tetragastrin , and gastrin-related tetrapeptide all increased cyclic gmp levels and guanylate cyclase activity in rat gastric mucosa , whole stomach , and duodenum . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
6,
13
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
22,
34
]
} |
human gastrin ( i ) , pentagastrin , tetragastrin , and gastrin-related tetrapeptide all increased cyclic gmp levels and guanylate cyclase activity in rat gastric mucosa , whole stomach , and duodenum . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
6,
13
]
} | {
"id": "C0039659",
"name": "gastrin",
"pos": [
56,
63
]
} |
the ed50 for human gastrin and pentagastrin was 0.01 microm , whereas the ed50 was 0.1 microm for tetragastrin and the tetrapeptide . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
19,
26
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
31,
43
]
} |
the ed50 for human gastrin and pentagastrin was 0.01 microm , whereas the ed50 was 0.1 microm for tetragastrin and the tetrapeptide . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
19,
26
]
} | {
"id": "C0039659",
"name": "tetragastrin",
"pos": [
98,
110
]
} |
cimetidine utilized at 1 microm or 1 mm concentrations partially blocked the augmentation by gastrin suggesting that part of this enhancement was through the histamine 2 receptor which has been shown to be important in pentagastrin-stimulated gastric acid release . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
93,
100
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
219,
231
]
} |
the effect of somatostatin on the release of thyrotropin and its subunits from bovine anterior pituitary cells in vitro . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
45,
56
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
86,
104
]
} |
the mean plasma concentration of norepinephrine or epinephrine in blood from a medial portal vessel was not different from that from a lateral portal vessel . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
33,
47
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
51,
62
]
} |
gh ( ghr ) and lactogenic receptors were analyzed after use of the cross-linking reagent ethylene glycol bis- ( succinimidyl succinate ) to attach covalently iodinated human gh ( hgh ) to binding proteins 1 ) on intact im-9 lymphocytes , 2 ) in a partially purified ghr preparation from rabbit liver , and 3 ) in crude m... | NA | {
"id": "C0023899",
"name": "preparation",
"pos": [
270,
281
]
} | {
"id": "C0982262",
"name": "fractions",
"pos": [
330,
339
]
} |
changes in tissue concentrations of thyrotropin , free thyrotropin beta , and alpha-subunits after thyroxine administration : comparison of mouse hypothyroid pituitary and thyrotropic tumors . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
36,
47
]
} | {
"id": "C0076641",
"name": "thyrotropin beta",
"pos": [
55,
71
]
} |
the availability of these cells plus essentially pure sm-c/insulin-like growth factor i , the most gh-dependent sm , has now made possible detailed studies of the interaction of this radiolabeled peptide with the gpc receptor and of the subsequent processing of this hormone by these cells . | NA | {
"id": "C0021665",
"name": "insulin-like growth factor i",
"pos": [
59,
87
]
} | {
"id": "C0037657",
"name": "sm",
"pos": [
112,
114
]
} |
analysis of the fate of [ 125i ] iodo-sm-c bound to gpcs at 37 c provided evidence that this hormone is internalized and extruded from the cell in a partially degraded form . | NA | {
"id": "C0225369",
"name": "gpcs",
"pos": [
52,
56
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
139,
143
]
} |
insulin-ricin b chain conjugate , a hybrid molecule consisting of insulin covalently linked to the binding chain of ricin , was tested for insulin-like biological activity in htc and h35 rat hepatoma cells , rat adipocytes , rat thymocytes , and human fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
200,
205
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
252,
263
]
} |
however , in rats given the high dose of ms the severe reduction in pituitary gonadotropin secretion is attributable in large part to the corresponding decrease in hypothalamic gnrh release , since nh restored the gnrh and lh/fsh plasma concentrations to pe levels . | NA | {
"id": "C0018066",
"name": "pituitary",
"pos": [
68,
77
]
} | {
"id": "C0018061",
"name": "gnrh",
"pos": [
214,
218
]
} |
amino acid analysis of an acid hydrolysate revealed no significant discrepancies from the amino acid composition of insulin-like growth factor i ( igf-i ) . | NA | {
"id": "C0815040",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
90,
100
]
} |
the prevalence of all types of epileptic seizures ( including febrile convulsions ) has been found to be 2,441/100,000 , whereas for patients with the diagnosis of epilepsy the rate is 1,274/100,000 . | NA | {
"id": "C0009952",
"name": "febrile convulsions",
"pos": [
62,
81
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
164,
172
]
} |
in addition , the risk-increasing effect of a febrile convulsive seizure on the development of epilepsy is analyzed . | NA | {
"id": "C0009952",
"name": "febrile",
"pos": [
46,
53
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
95,
103
]
} |
as to the initial diagnosis , the percentage of group i at the final follow-up was 81.8 % with febrile convulsions and 37.6 % with epilepsy . | NA | {
"id": "C0009952",
"name": "febrile convulsions",
"pos": [
95,
114
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
131,
139
]
} |
certain glia cells , notably astrocytes and tumor cells derived therefrom , express simultaneously two types of proteins of intermediate-sized filaments , vimentin and glia filament protein ( gfp ) . | NA | {
"id": "C0021769",
"name": "proteins",
"pos": [
112,
120
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
155,
163
]
} |
certain glia cells , notably astrocytes and tumor cells derived therefrom , express simultaneously two types of proteins of intermediate-sized filaments , vimentin and glia filament protein ( gfp ) . | NA | {
"id": "C0021769",
"name": "proteins",
"pos": [
112,
120
]
} | {
"id": "C0017626",
"name": "glia filament",
"pos": [
168,
181
]
} |
modulation of free fatty acid binding in isolated rat liver plasma membranes was evaluated using the fluorescent fatty acids trans-parinaric and cis-parinaric acid as analogues for saturated and unsaturated fatty acids , respectively . | NA | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
14,
29
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
207,
218
]
} |
modulation of free fatty acid binding in isolated rat liver plasma membranes was evaluated using the fluorescent fatty acids trans-parinaric and cis-parinaric acid as analogues for saturated and unsaturated fatty acids , respectively . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
113,
124
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
195,
218
]
} |
in the presence of atp , it is a competitive inhibitor against atp as well as leucine for the two isoenzymes , as is also shown for the photoinactive gamma-anilidate analog of atp , anatp , which does not serve as substrate in the enzyme reaction . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
98,
108
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
231,
237
]
} |
the b chain ( mr about 33000 ) contains the active site of the molecule , as demonstrated by labelling with [ 3h ] diisopropyl phosphofluoridate , and is homologous to the enzymatically active chains of thrombin , plasmin and other serine proteases . | NA | {
"id": "C0016016",
"name": "plasmin",
"pos": [
214,
221
]
} | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
232,
248
]
} |
mutants with thermosensitive npr1 gene product ( nprts ) have been used to discriminate between three possible roles of this protein , namely ( a ) a common constituent of a set of ammonia-sensitive permeases ; | NA | {
"id": "C1564139",
"name": "mutants",
"pos": [
0,
7
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
125,
132
]
} |
the acee structural gene comprises 2655 base pairs ( 885 codons , excluding the initiation codon aug ) , it is preceded by a good ribosome binding site and several potential rna polymerase binding sites . | NA | {
"id": "C0009221",
"name": "codons",
"pos": [
57,
63
]
} | {
"id": "C0242610",
"name": "initiation codon",
"pos": [
80,
96
]
} |
the equilibrium constant at 25 degrees c , measured using 31p nmr , for the reaction mg [ alpha beta ch2 ] atp + creatine in equilibrium mg [ alpha beta ch2 ] adp + phosphocreatine + h+ is 2.2 x 10 ( -12 ) m compared with a value of 2.5 x 10 ( -10 ) m for the same reaction with the normal substrates , corresponding to ... | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
113,
121
]
} | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
165,
180
]
} |
formation of linear , unbranched polymers of the enzyme-avidin complex is seen to occur when the ratio of avidin to enzyme is between 2:1 and 1:2 ; | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
49,
55
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
116,
122
]
} |
from the structure of the polymers and the observation of single enzyme-avidin complexes , we deduce that the biotin groups on the enzyme are located on the external faces of each subunit close to , and probably within 3 nm of , the intersubunit junction . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
65,
71
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
131,
137
]
} |
carboxylesterases in rat and human sera and their relationship of serum aryl acylamidases and cholinesterases . | NA | {
"id": "C0007067",
"name": "carboxylesterases",
"pos": [
0,
17
]
} | {
"id": "C0008429",
"name": "cholinesterases",
"pos": [
94,
109
]
} |
in the crystal , as in solution , both apo-isoenzymes reversibly bind the coenzyme derivative and catalyze a slow cleavage reaction , by which pyridoxal 5'-phosphate is produced and bound to the active-site lysine . | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
74,
82
]
} | {
"id": "C0034266",
"name": "pyridoxal",
"pos": [
143,
152
]
} |
three different preparations of beef heart cytochrome oxidase ( ec 1.9.3.1 ) were reconstituted into the membranes of artificial liposomes , and the electrical charge/electron ratios were determined for charge translocation coupled to enzymic activity . | NA | {
"id": "C0025256",
"name": "membranes",
"pos": [
105,
114
]
} | {
"id": "C0023828",
"name": "liposomes",
"pos": [
129,
138
]
} |
the latter was obtained by digestion of nuclei from ehrlich ascites tumor cells with the restriction nuclease bsp , which degrades main-band dna but leaves satellite dna intact . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
141,
144
]
} | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
156,
169
]
} |
it contains 22.1 % basic amino acids , mainly lysines , compared with a total of 8.6 % acidic residues . | NA | {
"id": "C0301714",
"name": "basic",
"pos": [
19,
24
]
} | {
"id": "C0024337",
"name": "lysines",
"pos": [
46,
53
]
} |
it is concluded that the conversion of protein phosphatase-1 to a manganese-ion dependent form is a quite separate phenomenon from the formation of the mg-atp-dependent protein phosphatase . | NA | {
"id": "C1956003",
"name": "protein",
"pos": [
39,
46
]
} | {
"id": "C0031686",
"name": "protein phosphatase",
"pos": [
169,
188
]
} |
the effect of microtubule disruption on the distribution of the cytoskeletal proteins , vinculin , alpha-actinin , and actin in normal and rsv-transformed fibroblasts . | NA | {
"id": "C0010852",
"name": "cytoskeletal",
"pos": [
64,
76
]
} | {
"id": "C0085175",
"name": "vinculin",
"pos": [
88,
96
]
} |
by double indirect immunofluorescence and interference electron microscopy , we have observed the effect of microtubule disruption by antimitotic drugs and coldness treatment on the distribution of adhesion sites and of the three cytoskeletal proteins , vinculin , alpha-actinin , and actin in normal rat cells and in ra... | NA | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
230,
251
]
} | {
"id": "C0085175",
"name": "vinculin",
"pos": [
254,
262
]
} |
in the group with myocardial infarction , a significant correlation between sigma r and ef existed only in patients with anterior myocardial infarction ( r:0.41 , p less than 0.025 ) . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
18,
39
]
} | {
"id": "C0340293",
"name": "anterior myocardial infarction",
"pos": [
121,
151
]
} |
flecainide acetate , a new class 1 agent , was therefore administered both intravenously and orally to 13 patients with recurrent paroxysmal tachycardia to assess whether the acute response to intravenous flecainide accurately predicts the response to oral therapy . | NA | {
"id": "C0086303",
"name": "flecainide acetate",
"pos": [
0,
18
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
205,
215
]
} |
parenteral administration of sericystatin a , an intracellular leukocyte inhibitor of the proinsulin-splitting enzyme cathepsin b , prolongs the mean survival time of mice with insulin-dependent myeloid leukemia . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
90,
100
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
177,
184
]
} |
the idiotype is identified with antisera and monoclonal antibodies prepared against the igm ( kappa ) antibody secreted by the epstein-barr virus-transformed human b cell line b17 . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
32,
40
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
102,
110
]
} |
the idiotype is identified with antisera and monoclonal antibodies prepared against the igm ( kappa ) antibody secreted by the epstein-barr virus-transformed human b cell line b17 . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
45,
66
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
102,
110
]
} |
when normal human b cells from blood , tonsil or spleen are cultured with 20-30 % autologous or allogeneic t cells and mitogen , the majority of cells rosette with sheep erythrocytes ( e ) after 3-5 days in culture . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
96,
106
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
129,
132
]
} |
mice were immunized with hapten [ nip , ( 4-hydroxy-5-iodo-3-nitrophenyl ) acetyl or tnp ( 2,4,6-trinitrophenyl ) ] conjugates of ficoll or pneumococcal polysaccharide type 14 ( s14 ) , and they were bled on days 10 or 14 . | NA | {
"id": "C0016071",
"name": "ficoll",
"pos": [
130,
136
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
153,
167
]
} |
we combined this approach with the use of cytolysis-inhibiting monoclonal antibodies ( mab ) , and found that antibody-induced decrease of cytolysis was correlated with a decrease in the percentage of strong or total conjugates , depending on the mab used . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
110,
118
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
247,
250
]
} |
the initial part of the noradrenaline contraction was resistant to verapamil ( ic50 74.2 microm ) , methoxyverapamil ( ic50 approximately 100 microm ) and especially nifedipine ( no effect up to 14.4 microm ) . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
67,
76
]
} | {
"id": "C0016986",
"name": "methoxyverapamil",
"pos": [
100,
116
]
} |
the late part of this response and the entire response to noradrenaline in the epididymal half were abolished by verapamil ( 10.2 microm ) , methoxyverapamil ( 9.6 microm ) or nifedipine ( 1.44 microm ) . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
113,
122
]
} | {
"id": "C0016986",
"name": "methoxyverapamil",
"pos": [
141,
157
]
} |
the second phase of the twitch was totally resistant to nifedipine ( 14.4 microm ) , but more sensitive to inhibition by verapamil or methoxyverapamil than was the first . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
121,
130
]
} | {
"id": "C0016986",
"name": "methoxyverapamil",
"pos": [
134,
150
]
} |
the operant behavioral effects of the substituted benzamides metoclopramide , sultopride and sulpiride were compared with those of chlorpromazine and haloperidol using lateral hypothalamic self-stimulation of the brain in rats and sidman avoidance responding in rats and squirrel monkeys . | NA | {
"id": "C0005029",
"name": "benzamides",
"pos": [
50,
60
]
} | {
"id": "C0025853",
"name": "metoclopramide",
"pos": [
61,
75
]
} |
the operant behavioral effects of the substituted benzamides metoclopramide , sultopride and sulpiride were compared with those of chlorpromazine and haloperidol using lateral hypothalamic self-stimulation of the brain in rats and sidman avoidance responding in rats and squirrel monkeys . | NA | {
"id": "C0005029",
"name": "benzamides",
"pos": [
50,
60
]
} | {
"id": "C0038803",
"name": "sulpiride",
"pos": [
93,
102
]
} |
in vivo rates of 5-hydroxytryptophan accumulation ( following administration of the decarboxylase inhibitor r04/4602/1 ) and levels of 5-ht in the nucleus raphe dorsalis ( dr ) , nucleus centralis superior ( ncs ) , nucleus septalis lateralis ( ls ) , nucleus suprachiasmaticus ( scn ) , nucleus hypothalamicus anterior ... | NA | {
"id": "C0000578",
"name": "hydroxytryptophan",
"pos": [
19,
36
]
} | {
"id": "C0041249",
"name": "l-tryptophan",
"pos": [
481,
493
]
} |
nafazatrom reduced the number of extrasystoles and the duration of ventricular tachycardia and fibrillation occurring in the early ( 0-10 min ) and late phases ( 2-4 h ) of cardiac arrhythmias observed in the controls . | NA | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
33,
46
]
} | {
"id": "C0003811",
"name": "cardiac arrhythmias",
"pos": [
173,
192
]
} |
using [ 3h ] qnb , we demonstrated that gtp and gpp ( nh ) p increased muscarinic receptor high affinity sites in bovine tracheal muscle preparations ; | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
40,
43
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
48,
60
]
} |
the gtp effect on increasing the receptor sites was relatively small ( 16 % ) , sensitive ( ed50 0.48 microm ) and specific ( gpp ( nh ) p greater than gtp = gdp greater than gmp much greater than atp ) . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
126,
138
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
152,
155
]
} |
a blood glucose response following l-dopa administration was seen in most of normal subjects while no increment of blood glucose was noticed in obese subjects . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
2,
15
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
121,
128
]
} |
circadian rhythms in adrenal adrenaline and noradrenaline and in blood glucose levels in the bandicoot rat ( bandicota bengalensis ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
29,
39
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
44,
57
]
} |
adrenaline , noradrenaline and blood glucose levels increased during 2400 h through 0600 h and decreased during 1200 h through 1800 h . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
13,
26
]
} |
previous studies have demonstrated that upon fusion with actively cycling human diploid fibroblast-like ( hdfl ) cells , senescent hdfl are capable of inhibiting the young nucleus from entry into dna synthesis ( norwood et al . ( 1974 ) [ 10 ] ; rabinovitch et al . ( 1980 ) [ 1 ] ) . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
88,
98
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
113,
118
]
} |
their labelled glycosaminoglycans were primarily dermatan sulfate and keratan sulfate , with traces of hyaluronic acid and heparan sulfate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
15,
33
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
123,
138
]
} |
no difference was found in the ratio of collagens type i and type iii synthesized , which were investigated as procollagens and after conversion to collagen as well . | NA | {
"id": "C0033235",
"name": "procollagens",
"pos": [
111,
123
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
148,
156
]
} |
in c3h mice , spontaneous recovery occurred after 3 weeks , accompanied by a reduction in putrescine and spermidine levels . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
90,
100
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
116,
122
]
} |
changes of the glycosaminoglycan ( gags ) fractions in the medium , the cell surface of human diploid skin fibroblasts and the relation between gags synthesis and cell growth in cultured media containing various ca++ concentrations were investigated by means of electrophoretic fractionation . | NA | {
"id": "C0007634",
"name": "the cell",
"pos": [
68,
76
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
107,
118
]
} |
activities of superoxide dismutase ( sod ) , catalase ( cat ) , and peroxidases ( per ) were examined at 24-h intervals during drosophila development . | NA | {
"id": "C0007367",
"name": "catalase",
"pos": [
45,
53
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
68,
79
]
} |
sod activities show a u-shaped curve from egg to adult stages whereas cat and per are consistently low in egg through larval stages . | NA | {
"id": "C0007367",
"name": "cat",
"pos": [
70,
73
]
} | {
"id": "C0031179",
"name": "per",
"pos": [
78,
81
]
} |
male and female larvae have similar activities of sod , cat , and per whereas male adults have elevated activities of these enzymes . | NA | {
"id": "C0007367",
"name": "cat",
"pos": [
56,
59
]
} | {
"id": "C0031179",
"name": "per",
"pos": [
66,
69
]
} |
a new 'silent ' abnormal hemoglobin , hb okayama [ beta 2 ( na 2 ) his replaced by gln ] , happened to be discovered in a diabetic japanese female living in okayama prefecture , japan , in the course of glyco-hb measurement of the blood samples of diabetic patients . | NA | {
"id": "C0019047",
"name": "abnormal hemoglobin",
"pos": [
16,
35
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
209,
211
]
} |
this polypeptide could be precipitated with antiserum to a narrow density cut of ldl ( d = 1.030-1.055 ) or antiserum against the high-mr form of apob ( apob 100 [ 4 ] ) . | NA | {
"id": "C0003593",
"name": "apob",
"pos": [
146,
150
]
} | {
"id": "C0205666",
"name": "apob 100",
"pos": [
153,
161
]
} |
islet-activating protein prevents nicotinic acid-induced gtpase stimulation and gtp but not gtp gamma s-induced adenylate cyclase inhibition in rat adipocytes . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
57,
60
]
} | {
"id": "C0079469",
"name": "not gtp gamma",
"pos": [
88,
101
]
} |
pretreatment of rats or intact rat adipocytes with iap did not affect adenylate cyclase inhibition by the stable gtp analog , gtp gamma s , whereas inhibition by gtp was abolished . | NA | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
126,
137
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
162,
165
]
} |
it is concluded that ptdins degradation can be provoked in isolated rat liver plasma membrane through alpha-adrenergic receptor activation and that this effect is dependent on divalent cations in the sense that loss of cations from the membrane allows degradation to commence . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
176,
192
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
219,
226
]
} |
three-dimensional models for human insulinlike growth factors ( igf-i and igf-ii ) have been constructed by using interactive molecular graphics . | NA | {
"id": "C0037657",
"name": "insulinlike growth factors",
"pos": [
35,
61
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
74,
79
]
} |
three-dimensional models for human insulinlike growth factors ( igf-i and igf-ii ) have been constructed by using interactive molecular graphics . | NA | {
"id": "C0037657",
"name": "insulinlike growth factors",
"pos": [
35,
61
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
74,
80
]
} |
thus , both the duration of the active phase of follicular stimulation and the e2 level at the day of induction of ovulation by human chorionic gonadotropin should be determined for optimal monitoring of human gonadotropin therapy . | NA | {
"id": "C0018062",
"name": "human",
"pos": [
128,
133
]
} | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
210,
222
]
} |
physical exercises , tissue plasminogen activator and fungii protease ( longolytin ) infusions , acetylsalicylic acid and brufen significantly increased content of the plasminogen activator with low initial level and had no such effect if the initial level of plasminogen activator was high enough . | NA | {
"id": "C0032143",
"name": "tissue plasminogen activator",
"pos": [
21,
49
]
} | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
260,
281
]
} |
as the antisera against peptide p-c did not have any cross-reactivity to other kinds of peptide including insulin , glucagon , somatostatin , pp , vip , human c-peptide and kallikrein , the present finding suggests that peptide p-c like immunoreactivity is present in the b-cells independently of insulin and proinsulin ... | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
159,
168
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
309,
319
]
} |
as the antisera against peptide p-c did not have any cross-reactivity to other kinds of peptide including insulin , glucagon , somatostatin , pp , vip , human c-peptide and kallikrein , the present finding suggests that peptide p-c like immunoreactivity is present in the b-cells independently of insulin and proinsulin ... | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
106,
113
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
309,
319
]
} |
electrophoretic analysis of the various glycosaminoglycan fractions showed an increase in hyalunoric acid and heparin , and a decrease in heparan sulfate , chondroitin-4-sulfate and chondroitin-6-sulfate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
40,
57
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
110,
117
]
} |
electrophoretic analysis of the various glycosaminoglycan fractions showed an increase in hyalunoric acid and heparin , and a decrease in heparan sulfate , chondroitin-4-sulfate and chondroitin-6-sulfate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
40,
57
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
138,
153
]
} |
the association between iud , ectopic pregnancy in general , and ovarian pregnancy in particular is discussed . | NA | {
"id": "C0032987",
"name": "ectopic pregnancy",
"pos": [
30,
47
]
} | {
"id": "C0032991",
"name": "ovarian pregnancy",
"pos": [
65,
82
]
} |
the characterization of a new silk protein mrna ( p25 mrna ) in posterior silkgland cells ( psg ) and the developmental variations of its cell molecular concentration versus that of fibroin mrna are described . | NA | {
"id": "C0074529",
"name": "silk",
"pos": [
30,
34
]
} | {
"id": "C0016042",
"name": "fibroin",
"pos": [
182,
189
]
} |
analysis of membrane proteins by sodium dodecyl sulfate-gel electrophoresis indicates that several high-molecular-weight proteins characteristic of plasma membranes from unfertilized eggs are absent in plasma membranes from fertilized eggs . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
12,
29
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
121,
129
]
} |
the 16 s rrna is the most prevalent embryo poly ( a ) rna , and is synthesized about four times more rapidly than is the mrna for cytochrome oxidase . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
9,
13
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
122,
125
]
} |
the kinds and relative amounts of 3h-labeled gag were analyzed by chromatography on a deae-cellulose column and cellulose thin-layer sheets . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
86,
100
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
112,
121
]
} |
we found hyaluronate and probably a minute quantity of heparan sulfate in the dental epithelium , while hyaluronate , heparan sulfate , and chondroitin sulfate were the main types of gag in the dental papilla . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
55,
70
]
} | {
"id": "C0017973",
"name": "gag",
"pos": [
183,
186
]
} |
eleven patients with ascitic cirrhosis and eleven patients without liver disease received 200 mg of cimetidine orally and intravenously . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
29,
38
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
67,
80
]
} |
the decrease in major lipid constituents ( cholesterol and phospholipids ) of hdl was mainly attributable to the decrease in those of hdl3 , except in some liver diseases of acute or severe stage ( acute hepatitis in an acute stage and hepatoma ) which were accompanied with a simultaneous moderate decrease in those of ... | NA | {
"id": "C0023895",
"name": "liver diseases of",
"pos": [
156,
173
]
} | {
"id": "C0015695",
"name": "fatty liver",
"pos": [
332,
343
]
} |
from results that hdl3- but not hdl2-cholesterol levels significantly correlated with serum total protein , albumin and choline esterase , it was suggested that the decrease in large constituents of hdl , particularly of hdl3 , is caused by hepatocellular dysfunction which causes inhibition of protein and lipid synthes... | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
108,
115
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
295,
302
]
} |
the enzyme activity was stimulated to the same extent in all groups by sodium fluoride , vasoactive intestinal polypeptide , or by substitution in the assay mixture of guanosine triphosphate by its hydrolysis-resistant analogue -- gtp gamma s . | NA | {
"id": "C0018353",
"name": "guanosine triphosphate",
"pos": [
168,
190
]
} | {
"id": "C0079469",
"name": "gtp",
"pos": [
231,
234
]
} |
metabolic balances across the leg were evaluated relative to food intake , energy expenditure , energy balance , nitrogen balance , and urinary excretion of urea , creatinine , adrenaline , and noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
177,
187
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
194,
207
]
} |
a hypothesis is suggested which turns down the opinion that alopecia or pathological wool shedding in sheep is due to some pathological processes or disease . | NA | {
"id": "C0030660",
"name": "pathological processes",
"pos": [
123,
145
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
149,
156
]
} |
a significant amount of dna extracted from the myxamoebae was hybridizable with purified phage lambda dna , and capable of forming phage particles when packaged in vitro with phage lambda proteins . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
102,
105
]
} |
cloned dna fragments coding for parts of strain wsn ( h1n1 ) influenza virus hemagglutinin ( ha ) were fused to a bacterial leader dna derived from the escherichia coli trp operon . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
7,
10
]
} | {
"id": "C0012924",
"name": "bacterial",
"pos": [
114,
123
]
} |
the patients received either d-penicillamine ( 600 mg/day ) , medroxyprogesterone acetate ( 5 mg/day ) , or a placebo , or no treatment after the d-penicillamine or medroxyprogesterone medication , each period lasting from nine to 15 months . | NA | {
"id": "C0065864",
"name": "medroxyprogesterone",
"pos": [
62,
81
]
} | {
"id": "C0025147",
"name": "medroxyprogesterone",
"pos": [
165,
184
]
} |
all commercially available combined oral contraceptives have 17-c-alkylated estrogens ( ethinylestradiol or mestranol ) as their estrogen components . | NA | {
"id": "C0015011",
"name": "ethinylestradiol",
"pos": [
88,
104
]
} | {
"id": "C0025506",
"name": "mestranol",
"pos": [
108,
117
]
} |
hyalinosis cutis et mucosae is a rare , probably autosomal-recessively inherited disease , which begins in the first weeks of life with a remarkable hoarseness due to deposits of hyaline material in the larynx . | NA | {
"id": "C0023795",
"name": "hyalinosis cutis et mucosae",
"pos": [
0,
27
]
} | {
"id": "C0019825",
"name": "hoarseness",
"pos": [
149,
159
]
} |
in 360 unselected patients with different gastroenterological diseases we found higher rates of positive hepatitis markers in non-specific inflammation and ulcer of stomach or small bowel as well as in liver diseases ( 24.5 resp . 41.7 % ) in comparison to a healthy population . | NA | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
105,
114
]
} | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
202,
216
]
} |
the effects of high and low concentrations of a variety of opioid peptides and naloxone on insulin release and islet c-amp levels were determined , alpha-endorphin , dynorphin , leu enkephalin and met enkephalin all stimulated insulin secretion significantly , though not to the same extent . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
59,
74
]
} | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
166,
175
]
} |
specificity of binding was studied in competition experiments between 125i-insulin , insulin , proinsulin , insulin-like growth factors and human growth hormone . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
75,
82
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
95,
105
]
} |
half-maximal inhibition of 125i-insulin binding was produced by proinsulin at 2 x 10 ( -9 ) mol/l and by insulin-like growth factors at 9 x 10 ( -9 ) mol/l . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
32,
39
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
64,
74
]
} |
thyroid hormone receptors in human cultured fibroblasts : evidence for cellular t4 transport and nuclear t3 binding . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
44,
55
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
71,
79
]
} |
intact human fibroblasts take up thyroxine ( t4 ) even more rapidly than t3 , with maximum after 5 min , showing a lower affinity for t4 than for t3 and a negligible specific and saturable binding sites for t4 , the presence of a cellular transport system for t4 may be hypothesized , considering that iodothyronine cell... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
316,
324
]
} |
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