text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in clinical perception , the syndrome has evolved from a neuropsychiatric disorder to a medical disease with an anatomic basis . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
29,
37
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
96,
103
]
} |
selected studies of wilms ' tumor and related renal neoplasms in children , which have been based on the national wilms ' tumor study pathology center collection of more than 2,600 renal tumors of childhood , are reviewed . | NA | {
"id": "C0022665",
"name": "renal neoplasms",
"pos": [
46,
61
]
} | {
"id": "C0027708",
"name": "wilms",
"pos": [
114,
119
]
} |
the purpose of the review is to illustrate the value of the collaborative approach to uncommon pathologic specimens and to distinguish several tumors often confused with wilms ' tumor , including renal adenocarcinoma , renal teratoma , and renal neurogenic tumors . | NA | {
"id": "C0027708",
"name": "wilms",
"pos": [
170,
175
]
} | {
"id": "C0022665",
"name": "renal",
"pos": [
240,
245
]
} |
under the designation primitive neuroectodermal tumors are included medulloblastomas and tumors that may differentiate in other directions , such as medulloepithelioma , neuroblastoma , polar spongioblastoma , pineoblastoma , ependymoblastoma , retinoblastoma , and olfactory neuroblastoma . | NA | {
"id": "C0027819",
"name": "neuroblastoma",
"pos": [
170,
183
]
} | {
"id": "C0206717",
"name": "olfactory neuroblastoma",
"pos": [
266,
289
]
} |
according to the lyon hypothesis , carriers of dmd should be mosaics of cells expressing the normal and dmd phenotypes , and their cultured skin fibroblasts should have intercellular adhesiveness intermediate between that for normal and dmd cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
145,
156
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
241,
246
]
} |
proteins of different sources were separated : total proteins of fibroblasts ( 12 cell lines ) , soluble proteins of fibroblasts ( 12 cell lines ) , structure-bound proteins of fibroblasts ( eight cell lines ) and soluble proteins of hair root cells ( 12 subjects ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
65,
76
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
244,
249
]
} |
cultured cells ( fibroblasts ) and native cells ( hair root cells ) showed a similar degree of variation . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
17,
28
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
60,
65
]
} |
compared with midrange fibroblasts [ population doubling level ( pdl ) = 20 to 30 ] aged fibroblasts ( pdl greater than 40 ] were larger in size in terms of protein and rna per cell , generally proliferated more slowly , exhibited different steady state [ 3h ] proline transfer rna ( trna ) precursor pool specific radio... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
23,
34
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
177,
181
]
} |
compared with midrange fibroblasts [ population doubling level ( pdl ) = 20 to 30 ] aged fibroblasts ( pdl greater than 40 ] were larger in size in terms of protein and rna per cell , generally proliferated more slowly , exhibited different steady state [ 3h ] proline transfer rna ( trna ) precursor pool specific radio... | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
169,
172
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
269,
281
]
} |
cell size ( protein/cell ) was the variable that had the highest correlation with the reduction in collagen synthesis observed in human lung fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
0,
4
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
141,
152
]
} |
it is concluded that normal human serum contains natural antibodies against bo which form complement-activating immune complexes with bo by binding it to their f ( ab ) region . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
57,
67
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
112,
128
]
} |
immune complexes were formed in vitro with antibodies obtained from rabbits immunized with bovine serum albumin in freund 's complete ( fca ) or incomplete ( fia ) adjuvant . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
0,
16
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
43,
53
]
} |
when injected into rabbit knee joints , the immune complexes formed at maximum precipitation proportions with fca or fia antibodies caused a moderate leucocyte migration into the joints with maximum cell counts 6-8 hr after injection . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
44,
60
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
121,
131
]
} |
injection into the joints of immune complexes formed with fca antibodies at antigen excess induced a pronounced leucocyte migration with maximum numbers 18 hr after injection . | NA | {
"id": "C0003313",
"name": "immune",
"pos": [
29,
35
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
62,
72
]
} |
the imf distribution of vep10 antigen on various cell types and successful blocking experiments with okt10 revealed that both antibodies seem to recognize the same or closely related epitopes on cell membranes . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
30,
37
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
183,
191
]
} |
specificity of the rabbit anti-lamprey antibody antiserum was determined by absorbing the antiserum with ' o'rbc coated with a variety of antibody- and non-antibody-containing serum fractions . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
48,
57
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
156,
164
]
} |
comparison of purified sef and purified pec by immunological and biochemical criteria by immunodiffusion , isoelectric focusing , sodium dodecyl sulfate-polyacrylamide gel electrophoresis , and western blot analysis show that the toxins are immunologically identical and strongly suggest that the two nominal tss toxins ... | NA | {
"id": "C0015309",
"name": "pec",
"pos": [
40,
43
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
313,
319
]
} |
lack of antibodies to human heart tissue in sera of rhesus monkeys immunized with streptococcus mutans antigens and comparative study with rabbit antisera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
8,
18
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
146,
154
]
} |
a role for electrostatic forces in the aggregation was indicated by : ( i ) nacl inhibition of aggregation , and ( ii ) a great decrease in aggregation potency as a result of chemical modification of either cationic or anionic groups of afh1 . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
22,
23
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
219,
226
]
} |
total proteins of the two phagosomes were compared with each other , l-cell proteins , and surface-labeled proteins from macrophages . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
6,
14
]
} | {
"id": "C0025252",
"name": "surface",
"pos": [
91,
98
]
} |
if two or three principal constituents of the alloys are known , it is possible to classify them into 4 groups : high-gold alloys , gold-reduced alloys , palladium-silver alloys and base metal alloys . | NA | {
"id": "C0018027",
"name": "gold",
"pos": [
118,
122
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
193,
199
]
} |
over the past 30 years the 'traditional ' gold alloy systems have been modified by reducing the percentage of gold and other noble metals to the point where the 'non-precious metal ' alloys have no noble metal content . | NA | {
"id": "C0018027",
"name": "gold alloy",
"pos": [
42,
52
]
} | {
"id": "C0002154",
"name": "metal",
"pos": [
204,
209
]
} |
the expense of manipulating the base metal alloys to some extent offsets their cost-benefit advantage over traditional gold alloys . | NA | {
"id": "C0002154",
"name": "alloys",
"pos": [
43,
49
]
} | {
"id": "C0018027",
"name": "gold alloys",
"pos": [
119,
130
]
} |
a crystalline silica ( standard quartz dq12 with particle size less than 5 microns ) is able to stimulate in balb/c mice the production of ige and igg1 antibody to a single 1-microgram dose of ovalbumin . | NA | {
"id": "C0037098",
"name": "silica",
"pos": [
14,
20
]
} | {
"id": "C0034387",
"name": "quartz",
"pos": [
32,
38
]
} |
the diethylenetriaminepentaacetic acid ( dtpa ) complexes of the convenient half-life positron emitters 55co and 64cu have been prepared for quantitation of cerebrospinal fluid ( csf ) kinetics in different areas of the brain using positron emission tomography . | NA | {
"id": "C0018517",
"name": "half-life",
"pos": [
76,
85
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
185,
193
]
} |
characterization of the surface proteins of sv40-transformed mouse and human cells : absence of sv40-specific proteins . | NA | {
"id": "C0025252",
"name": "surface proteins",
"pos": [
24,
40
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
110,
118
]
} |
we have studied the effects of four doses of atenolol in 11 patients with stable angina pectoris using a symptom-limited exercise test and angina diaries . | NA | {
"id": "C0340288",
"name": "stable",
"pos": [
74,
80
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
139,
145
]
} |
the influence of the chelating agents cana2-edta , penicillamine , dimercaprol , unithiol , dithiocarb , aurin tricarboxylic acid , salicylic acid , and acetylsalicylic acid on the toxicity of oxygen at elevated tension was studied in mice . | NA | {
"id": "C0012383",
"name": "dimercaprol",
"pos": [
67,
78
]
} | {
"id": "C0041738",
"name": "unithiol",
"pos": [
81,
89
]
} |
nine patients had been in good health before the infection , although five patients were taking systemic corticosteroids before their infection was diagnosed . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
49,
58
]
} | {
"id": "C0243026",
"name": "systemic",
"pos": [
96,
104
]
} |
these data therefore suggested that minor oral surgical procedures , in common with major surgery , trauma , burn injury , hemorrhagic shock and widespread malignant disease , are followed by depression of reticulo-endothelial function , a feature that has implications for wound repair and resistance to both infection ... | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
100,
106
]
} | {
"id": "C0006434",
"name": "burn injury",
"pos": [
109,
120
]
} |
the curtius rearrangement was carried out on the n-protected aminoacyl azides obtained from the n-protected aminoacyl hydrazide by nitrosyl chloride or by sodium azide reaction with an appropriate mixed carboxylic carbonic acid anhydride . | NA | {
"id": "C0004492",
"name": "azides",
"pos": [
71,
77
]
} | {
"id": "C0074721",
"name": "sodium azide",
"pos": [
155,
167
]
} |
conformational parameters of the opioid peptides dynorphin and [ leu5 ] enkephalin in dilute aqueous solution ( 3 x 10 ( -5 ) m ) were investigated by performing singlet-singlet energy transfer experiments with dynorphin and with the biologically active 4-tryptophan analogs of dynorphin- ( 1-13 ) and [ leu5 ] enkephali... | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
33,
48
]
} | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
278,
287
]
} |
conformational parameters of the opioid peptides dynorphin and [ leu5 ] enkephalin in dilute aqueous solution ( 3 x 10 ( -5 ) m ) were investigated by performing singlet-singlet energy transfer experiments with dynorphin and with the biologically active 4-tryptophan analogs of dynorphin- ( 1-13 ) and [ leu5 ] enkephali... | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
33,
48
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
311,
321
]
} |
entropies of transfer of a peptide backbone unit ( ch2conh ) and peptide group ( conh ) from water to aqueous ethanol solutions were derived from the enthalpy of transfer data and the free energies of transfer of glycine , alpha-alanine , beta-alanine and diglycine . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
229,
236
]
} | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
239,
251
]
} |
the specific effect of zinc and other heavy metals on the growth and nutrition of rhizopus . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
23,
27
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
38,
50
]
} |
carbohydrate-nitrogen and base element relationships of peas grown in water culture under various light exposures . | NA | {
"id": "C0028158",
"name": "nitrogen",
"pos": [
13,
21
]
} | {
"id": "C0013879",
"name": "element",
"pos": [
31,
38
]
} |
a new method for the determination of cellulose , based upon observations on the removal of lignin and other encrusting materials . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
38,
47
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
92,
98
]
} |
the proteins of grasses : the cystine content of certain grasses and other pasture plant proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
4,
12
]
} | {
"id": "C0032089",
"name": "plant proteins",
"pos": [
83,
97
]
} |
the metabolism of galactose : phosphorylation during galactose fermentation and its relation to the interconversion of hexoses . | NA | {
"id": "C0016945",
"name": "galactose",
"pos": [
18,
27
]
} | {
"id": "C0019494",
"name": "hexoses",
"pos": [
119,
126
]
} |
metabolism of amino-acids : the synthesis of glutamine from glutamic acid and ammonia , and the enzymic hydrolysis of glutamine in animal tissues . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
60,
73
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
118,
127
]
} |
experiments confirming the antiscorbutic activity of dehydroascorbic acid and a study of its storage and that of ascorbic acid by the guinea-pig at different levels of intake . | NA | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
53,
73
]
} | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
113,
126
]
} |
studies on bile pigments : a study of ehrlich 's test for urobilinogen and schlesinger 's reaction for urobilin . | NA | {
"id": "C0005402",
"name": "bile pigments",
"pos": [
11,
24
]
} | {
"id": "C0042052",
"name": "urobilinogen",
"pos": [
58,
70
]
} |
studies on bile pigments : a study of ehrlich 's test for urobilinogen and schlesinger 's reaction for urobilin . | NA | {
"id": "C0005402",
"name": "bile pigments",
"pos": [
11,
24
]
} | {
"id": "C0042051",
"name": "urobilin",
"pos": [
103,
111
]
} |
the mechanism of degradation of starch by amylases : kinetics of action of alpha- and beta-amylases on starch , its components and partial degradation products . | NA | {
"id": "C0002712",
"name": "amylases",
"pos": [
42,
50
]
} | {
"id": "C0005194",
"name": "beta-amylases",
"pos": [
86,
99
]
} |
the estimation of sugars in the leaf of the mangold ( beta vulgaris ) : methods for the estimation of fructose , glucose and sucrose . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
18,
24
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
125,
132
]
} |
studies on bile pigments : the quantitative determination of urobilin and urobilinogen in urine and faeces . | NA | {
"id": "C0005402",
"name": "bile pigments",
"pos": [
11,
24
]
} | {
"id": "C0042051",
"name": "urobilin",
"pos": [
74,
82
]
} |
studies upon the mode of action of vitamin d : investigations upon the phosphorus compounds in muscles , liver and kidneys as influenced by different levels of vitamin d and phosphorus in the diet . | NA | {
"id": "C0206756",
"name": "phosphorus",
"pos": [
71,
81
]
} | {
"id": "C0080014",
"name": "phosphorus",
"pos": [
174,
184
]
} |
the digestibility of dietary protein in the ruminant : the digestibility of protein following a prolonged fast , with a detailed study of the nitrogen metabolism . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
21,
36
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
76,
83
]
} |
the biochemistry of silicic acid : the solution of silica and silicate dusts in body fluids . | NA | {
"id": "C0037105",
"name": "silicic acid",
"pos": [
20,
32
]
} | {
"id": "C0086983",
"name": "silicate",
"pos": [
62,
70
]
} |
new zealand fish oils : seasonal variations in the vitamin a content of ling ( genypterus blacodes ) liver oil . | NA | {
"id": "C0016157",
"name": "fish oils",
"pos": [
12,
21
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
107,
110
]
} |
the effect of water drinking , mineral starvation and salt administration on the total osmotic pressure of the blood in man , chiefly in relation to the problems of water absorption and water diuresis . | NA | {
"id": "C0599638",
"name": "water drinking",
"pos": [
14,
28
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
186,
191
]
} |
on the biological assay of the cortical hormone by the survival method , in adrenalectomized young rats , and on the influence of the salt content of the hormone extract . | NA | {
"id": "C0001617",
"name": "cortical hormone",
"pos": [
31,
47
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
154,
161
]
} |
on the differential diagnosis of volvulus from other forms of acute mechanical obstruction of the small intestine . | NA | {
"id": "C0042961",
"name": "volvulus",
"pos": [
33,
41
]
} | {
"id": "C0021843",
"name": "of",
"pos": [
91,
93
]
} |
these pictures illustrate the principal phenomena accompanying the development of this organism on ordinary nutrient media , on media consisting exclusively of either peptones or proteins , and on media containing small amounts of licl . | NA | {
"id": "C0030966",
"name": "peptones",
"pos": [
167,
175
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
179,
187
]
} |
in media containing embryonic tissue juice , or other growth-activating substances , fibroblasts form colonies that are isomorphic and composed of isomorphic cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
85,
96
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
158,
163
]
} |
the preparation is described of a deep red protein dye , r-salt-azo-benzidine-azo-crystalline egg albumen , which contains no more than traces of protein with the original egg albumen specificity . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
43,
50
]
} | {
"id": "C0001924",
"name": "albumen",
"pos": [
176,
183
]
} |
the method gives the actual weight of precipitin and may be applied to the determination of the maximum amount of precipitable antibody in any antiserum . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
127,
135
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
143,
152
]
} |
they were non-toxic for rabbits and mice , and failed to engender antibodies ( precipitins ) in rabbits . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
66,
76
]
} | {
"id": "C0032936",
"name": "precipitins",
"pos": [
79,
90
]
} |
in the guinea pig , chronic scurvy with superimposed infection ( beta streptococcus ) and to a lesser extent chronic scurvy alone , produces an arthropathy with striking pathologic similarities to that of rheumatic fever and the closely allied condition of rheumatoid arthritis . | NA | {
"id": "C0035436",
"name": "rheumatic fever",
"pos": [
205,
220
]
} | {
"id": "C0003864",
"name": "arthritis",
"pos": [
268,
277
]
} |
it is suggested that a subclinical degree of scurvy may constitute the rheumatic tendency in which the added factor of infection causes the development of rheumatic fever or possibly the closely allied condition of rheumatoid arthritis . | NA | {
"id": "C0035436",
"name": "rheumatic fever",
"pos": [
155,
170
]
} | {
"id": "C0003864",
"name": "arthritis",
"pos": [
226,
235
]
} |
in immune serum , the a carbohydrate brings about a quantitatively greater reduction in opsonic activity than its derivatives , but it has not been possible to demonstrate complete inhibition of phagocytic action by the method of absorption of antibody . | NA | {
"id": "C0020960",
"name": "immune serum",
"pos": [
3,
15
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
244,
252
]
} |
histamine , choline , and adenosine depress the level of the blood pressure more effectively than they constrict the volume of the kidneys , while the reverse is true when adenylic acid is employed . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
26,
35
]
} | {
"id": "C0001465",
"name": "adenylic",
"pos": [
172,
180
]
} |
an ulcerative stomatitis associated with leucopenia and granulopenia can be induced in dogs by means of a diet causing black tongue . | NA | {
"id": "C0023530",
"name": "leucopenia",
"pos": [
41,
51
]
} | {
"id": "C0001824",
"name": "granulopenia",
"pos": [
56,
68
]
} |
the chemical differences between the two types are manifested principally in optical rotation , and in the simple sugars resulting from hydrolytic cleavage of the specific carbohydrates . | NA | {
"id": "C0026492",
"name": "simple sugars",
"pos": [
107,
120
]
} | {
"id": "C0007004",
"name": "carbohydrates",
"pos": [
172,
185
]
} |
from meningitis in man , encephalitis in cattle and sheep , a myocardial infection in fowl , and a generalized infection in rabbits , different observers have isolated gram-positive organisms which are closely related . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
73,
82
]
} | {
"id": "C0243026",
"name": "generalized infection",
"pos": [
99,
120
]
} |
it would be of interest if this phenomenon of prevention of antigenic capacity by proper amounts of immune serum might apply to such materials which by their very nature do not multiply in the body of the host , e.g. , toxin and antitoxin . | NA | {
"id": "C0020960",
"name": "immune serum",
"pos": [
100,
112
]
} | {
"id": "C0003445",
"name": "antitoxin",
"pos": [
229,
238
]
} |
theobald smith ( 8 ) and later park ( 9 ) demonstrated that in mixtures of diphtheria toxin-antitoxin , when smaller amounts of immune serum ( antitoxin ) are used , the toxicity of the mixture is retained and immunity results ; | NA | {
"id": "C0020960",
"name": "immune serum",
"pos": [
128,
140
]
} | {
"id": "C0003445",
"name": "antitoxin",
"pos": [
143,
152
]
} |
if a preventive action of antitoxic serum could be shown under these circumstances , a remarkable correlation of the reactions of proper amounts of antitoxin to toxoid and of proper amounts of immune serum on the virus would be evident . | NA | {
"id": "C0003445",
"name": "antitoxin",
"pos": [
148,
157
]
} | {
"id": "C0020960",
"name": "immune serum",
"pos": [
193,
205
]
} |
since other fats and oils which have been irradiated are bactericidal on account of the active oxygen released on contact with bacteria , the mechanism of the bactericidal action of irradiated lipids of the skin must be similar because the lipids have the properties of other irradiated fats and oils . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
193,
199
]
} | {
"id": "C0015677",
"name": "fats",
"pos": [
287,
291
]
} |
since other fats and oils which have been irradiated are bactericidal on account of the active oxygen released on contact with bacteria , the mechanism of the bactericidal action of irradiated lipids of the skin must be similar because the lipids have the properties of other irradiated fats and oils . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
193,
199
]
} | {
"id": "C0028908",
"name": "oils",
"pos": [
296,
300
]
} |
quantitative data obtained on cross reactions with the two antigens differ markedly from data on the corresponding reactions in the egg albumin system and indicate that tyrosine and perhaps histidine , while important in determining the serological specificity of egg albumin , have little connection with the specificit... | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
136,
143
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
325,
338
]
} |
homologous organisms in each case absorb all antibodies from their respective antisera , while organisms of the heterologous related type absorb only the antibody responsible for the cross reactions . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
78,
86
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
154,
162
]
} |
a high degree of immunity , characterized by protective antibodies in the serum , was produced in some guinea pigs by prolonged treatment with large doses of homologous vaccine , while sera of guinea pigs vaccinated in the ordinary manner contained no detectable neutralizing antibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
56,
66
]
} | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
263,
286
]
} |
the weight at birth represents , it is to be presumed ( at least in mice , and for certain other cases ) , the weight at a particular developmental stage . | NA | {
"id": "C0005612",
"name": "weight",
"pos": [
4,
10
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
111,
117
]
} |
the solubilities of l-proline and l-hydroxyproline in water , the calculated heats of solution , and the partial molal volume of l-hydroxyproline . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
22,
29
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
131,
145
]
} |
it is concluded that the immunological specificity of the globulin fractions as evidenced by the precipitation reaction is not determined by lipoids associated with the protein . | NA | {
"id": "C0017649",
"name": "globulin",
"pos": [
58,
66
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
169,
176
]
} |
by diffusion effect is understood a redistribution of the ions in a system where a continuous diffusion of one electrolyte is going on , which results in a steady state showing accumulation and impoverishment of certain ions . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
111,
122
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
220,
224
]
} |
when a fucus egg develops near one end in a close fitting capillary tube of pyrex glass or silica ( quartz ) , diffusion of substances passing to and from the egg is more impeded on the side of the egg toward the far end of the tube . | NA | {
"id": "C0037098",
"name": "silica",
"pos": [
91,
97
]
} | {
"id": "C0034387",
"name": "quartz",
"pos": [
100,
106
]
} |
they are then exposed for 3 hours or less to 0.01 m nacl , nascn , or guanidine chloride , which reduce the time required for the action current to about 1 second ( the normal time is 15 to 30 seconds ) . | NA | {
"id": "C0037494",
"name": "nacl",
"pos": [
52,
56
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
80,
88
]
} |
the failure to demonstrate the presence in the immune serum of an antibody , distinct from the anticarbohydrate antibody , analogous to that found in the normal serum , may be due to the experimental difficulty of removing all the anticarbohydrate antibody from a concentrated immune serum . | NA | {
"id": "C0020960",
"name": "immune serum",
"pos": [
47,
59
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
248,
256
]
} |
thus it is seen that a single well defined antibody ( the anticarbohydrate antibody ) may be responsible for the phagocytic action of normal unheated serum , normal heated serum , inactivated immune serum , and immune serum activated by complement . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
43,
51
]
} | {
"id": "C0020960",
"name": "immune serum",
"pos": [
211,
223
]
} |
so far as could be determined by the methods employed , the acetyl polysaccharide in highly purified form absorbs from type i antipneumococcus serum all demonstrable type-specific precipitins , agglutinins and protective antibodies . | NA | {
"id": "C0032936",
"name": "precipitins",
"pos": [
180,
191
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
221,
231
]
} |
under the experimental conditions of this study , no type-specific precipitins , agglutinins or protective antibodies were demonstrable in the serum of rabbits following repeated intravenous injections of the type i acetyl polysaccharide . | NA | {
"id": "C0032936",
"name": "precipitins",
"pos": [
67,
78
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
107,
117
]
} |
bile salt alone will raise the cholesterol output in the bile as much and often more than a cholesterol rich diet . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
31,
42
]
} | {
"id": "C0008395",
"name": "cholesterol",
"pos": [
92,
103
]
} |
bile salt alone will raise the cholesterol output in the bile as much and often more than a cholesterol rich diet . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
31,
42
]
} | {
"id": "C0008395",
"name": "cholesterol",
"pos": [
92,
103
]
} |
bile salt alone will raise the cholesterol output in the bile as much and often more than a cholesterol rich diet . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
31,
42
]
} | {
"id": "C0008395",
"name": "cholesterol",
"pos": [
92,
103
]
} |
the close analogy between the clinical manifestations and pathological processes of this disease in the rabbit and small pox in man led to the conclusion that the disease in the rabbit is essentially the same as small pox , and that it is probably produced by a virus closely related to the virus of small pox . | NA | {
"id": "C0030660",
"name": "pathological processes",
"pos": [
58,
80
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
163,
170
]
} |
the antisera that were produced following injections of emulsions of autolyzed homologous brain were shown by absorption tests to contain both specific and non-specific antibodies . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
4,
12
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
169,
179
]
} |
washed elementary bodies obtained from dermal vaccine virus contain ash , carbohydrate , fat , and nitrogen a part of which is undoubtedly in the form of protein . | NA | {
"id": "C0013879",
"name": "elementary",
"pos": [
7,
17
]
} | {
"id": "C0028158",
"name": "nitrogen",
"pos": [
99,
107
]
} |
the groups in protein which participate in its reaction with diazo compounds probably include aliphatic amines , the imidazole ring of histidine , the indole group of tryptophane , the nh of proline and hydroxyproline and the phenyl group of tyrosine . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
191,
198
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
203,
217
]
} |
the failure of large amounts of immune horse serum to protect mice against pneumococcus infection is explicable on the basis of selective participation of lipids dependent upon the species from which the antibody is derived . | NA | {
"id": "C0020960",
"name": "immune",
"pos": [
32,
38
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
204,
212
]
} |
it was concluded that , whereas in some individuals dietary proteins may be able to produce a significant increase in the serum protein concentration , the potency ratios are not sufficiently different to warrant the administration of any one protein in preference to another . | NA | {
"id": "C0012177",
"name": "dietary proteins",
"pos": [
52,
68
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
243,
250
]
} |
in nephritic edema the lymphatic capillaries are wider than normal but not as wide as in cardiac edema . | NA | {
"id": "C0013604",
"name": "edema",
"pos": [
13,
18
]
} | {
"id": "C0013608",
"name": "cardiac edema",
"pos": [
89,
102
]
} |
these observations lend further support to the thesis that , in the course of physiological coagulation , ( a ) calcium plus platelets ( or tissue derivative ) constitute an enzyme system which reacts with prothrombin to form thrombin , and which is thus analogous to trypsin and to several of the proteolytic venoms her... | NA | {
"id": "C0042479",
"name": "venoms",
"pos": [
310,
316
]
} | {
"id": "C0037380",
"name": "snake venoms",
"pos": [
468,
480
]
} |
the viscerotropic virulence of the virus appeared somewhat diminished , in that when injected subcutaneously into rhesus monkeys or hedgehogs it failed to produce a fatal infection , although there is evidence to indicate that a generalized infection takes place as demonstrated by the appearance of virus in the circula... | NA | {
"id": "C0243026",
"name": "generalized infection",
"pos": [
229,
250
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
371,
380
]
} |
in the region of antigen excess , a linear relation is found between the ratio of antibody to antigen in the precipitate and the amount of antiserum used . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
82,
90
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
139,
148
]
} |
the generally held view has been that in any immune serum only a single antibody would be induced by and react with a single antigen . | NA | {
"id": "C0020960",
"name": "immune serum",
"pos": [
45,
57
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
72,
80
]
} |
the simplest explanation of this situation is that different horses form antibodies differing in specific protective capacity , but from our studies it seems probable that in any immune serum there may occur a mixture of antibodies which , while directed against the same antigen , possess different protective capacitie... | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
73,
83
]
} | {
"id": "C0020960",
"name": "immune serum",
"pos": [
179,
191
]
} |
it would now appear that this latter hypothesis is the more tenable since the experiments here reported indicate the existence of antibodies of various protective potencies in horse antisera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
130,
140
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
182,
190
]
} |
the observations on the antibodies of both horse and rabbit antisera will be supported by experiments with immunochemical fractionation which will be reported in a subsequent paper . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
24,
34
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
60,
68
]
} |
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