text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
egg albumin also enters the blood capillaries , but much more rapidly than the other two proteins , due probably to the smaller molecular size . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
4,
11
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
89,
97
]
} |
it does not give rise to antibodies , but precipitates immune sera against hemolytic streptococci , and is therefore a hapten . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
25,
35
]
} | {
"id": "C0020960",
"name": "immune sera",
"pos": [
55,
66
]
} |
on immunization with such antigens immune sera were obtained containing two separate , unrelated antibodies , each specific for one of the two groups and separable by absorption . | NA | {
"id": "C0020960",
"name": "immune sera",
"pos": [
35,
46
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
97,
107
]
} |
antibodies against this substance were not found in antisera against native bull spermatozoa but were formed when vibrated spermatozoa or heads were injected into rabbits . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
52,
60
]
} |
the evidence as a whole favors the view that the virus stimulates the formation of the virus-neutralizing and complement-binding antibodies in vivo , and many facts indicate that it is closely associated , and in all probability identical , with the antigen that reacts with immune serum to fix complement in vitro . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
129,
139
]
} | {
"id": "C0020960",
"name": "immune serum",
"pos": [
275,
287
]
} |
syphilitic aneurysm of left coronary artery with concurrent aneurysm of a sinus of valsalva , and an additional case of valsalva aneurysm alone . | NA | {
"id": "C0018789",
"name": "aneurysm of",
"pos": [
11,
22
]
} | {
"id": "C0002940",
"name": "aneurysm",
"pos": [
129,
137
]
} |
multiple tumors of the sympathetic nervous system : report of a case showing a distinct ganglioneuroma , a neuroblastoma and a cystic calcifying ganglioneuroblastoma . | NA | {
"id": "C0027819",
"name": "neuroblastoma",
"pos": [
107,
120
]
} | {
"id": "C0206718",
"name": "ganglioneuroblastoma",
"pos": [
145,
165
]
} |
the decrease in electric mobility of proteins in solutions is readily predicted for gelatin in acetate buffers and for egg albumin in the presence of the alkali halides , of acetate buffers , and of hydrochloric acid on the basis of the assumptions made . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
37,
45
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
123,
130
]
} |
it is pointed out that the observed difference in the distribution ratio of cations from that of the chloride anion is probably to be explained by the influence of protein in lowering the activity coefficient of cations when on the alkaline side of the isoelectric point . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
101,
109
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
110,
115
]
} |
the effect of cyanide and of variation in alkalinity on the oxidation-reduction potential of the hemoglobin-methemoglobin system . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
97,
107
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
108,
121
]
} |
from the magnitude of the effect produced by cyanide and by variation in ph on the oxidation-reduction potential of the methemoglobin-hemoglobin system , it is concluded that cyanmethemoglobin and alkaline methemoglobin are undissociated ferric compounds , the first with cyanide and the second with hydroxyl . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
123,
133
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
206,
219
]
} |
it is probable that the very thin protoplasmic layer of these species , which is certainly no thicker than 8micro , is sufficient to obstruct the passage of proteins having large molecules , like egg albumen , with a degree of efficiency that is extraordinary . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
157,
165
]
} | {
"id": "C0001924",
"name": "albumen",
"pos": [
200,
207
]
} |
the assumption that , at the equivalence point in specific precipitin reactions , the antigen molecule is completely covered with a single layer of antibody-globulin molecules has been shown to account fairly well for the antibody-antigen ratios of some representative native single proteins , and the pneumococcus s iii... | NA | {
"id": "C0017649",
"name": "globulin",
"pos": [
157,
165
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
283,
291
]
} |
this has led to the idea that electrolytes pass chiefly as ions through the protoplasmic surface in which the order of ionic mobilities is supposed to correspond to that found in water . | NA | {
"id": "C0013832",
"name": "electrolytes",
"pos": [
30,
42
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
119,
124
]
} |
if this correspondence could be demonstrated it would not prove that electrolytes pass chiefly as ions through the protoplasmic surface for such a correspondence could exist if the movement were mostly in molecular form . | NA | {
"id": "C0013832",
"name": "electrolytes",
"pos": [
69,
81
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
98,
102
]
} |
the anions , which in plasma are mostly chloride , could pass this barrier into the secretion . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
4,
10
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
40,
48
]
} |
in order to have hydrochloric acid formation , anion exchange would have to occur , bicarbonate , lactate , or some other anion from the gland lumen returning to balance chloride entering , leaving the hydrogen ion from the weaker acid in the secretion . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
47,
52
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
170,
178
]
} |
the system : hemolyzed blood + glucose never exhibits glycolysis or , in the air , oxidation of glucose . | NA | {
"id": "C0005802",
"name": "blood",
"pos": [
23,
28
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
96,
103
]
} |
in native egg albumin no sh groups are detectable , whereas in completely coagulated albumin as many groups are detectable as are found in the hydrolyzed protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
14,
21
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
154,
161
]
} |
normal red cells do not adsorb protein even from concentrated solutions , as is evidenced by the finding that the ratio of the mobility of the cells to that of the proteins themselves is at least as high in concentrated casein , albumin , gelatin , or fibrinogen solutions as in dilute . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
164,
172
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
229,
236
]
} |
below the ph of neutralization of boric acid , they are proportional to the concentration of borate anions . | NA | {
"id": "C0006007",
"name": "borate",
"pos": [
93,
99
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
100,
106
]
} |
this action of the guaiacol ion is in marked contrast to the behavior of other anions whose effect resembles that of cl ( - ) . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
8,
11
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
79,
85
]
} |
these results are discussed in connection with the concept of the general definition of the isoelectric point and the behavior of certain insoluble proteins such as wool and silk fibroin . | NA | {
"id": "C0074529",
"name": "silk",
"pos": [
174,
178
]
} | {
"id": "C0016042",
"name": "fibroin",
"pos": [
179,
186
]
} |
the retention of chloride may well be due to the fact that even when the halide concentration of the sea water is reduced as low as 0.4 m , there is still an inwardly directed activity gradient of sodium chloride . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
17,
25
]
} | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
197,
212
]
} |
a comparison of h-ion changes in roller tube cultures of five pure strains of rat sarcoma cells and one strain of normal rat fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
90,
95
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
125,
136
]
} |
unlabelled : ( 1 ) the reaction of cementum and its adjoining tissues to induced pathological conditions associated with the gingival sulcus is described . ( 2 ) after subjecting the sulcus to interference , its histological appearance is compared with that of definite parodontal disease . ( 3 ) various methods were ad... | NA | {
"id": "C0030660",
"name": "pathological conditions",
"pos": [
81,
104
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
281,
288
]
} |
contraction ring : treatment by amyl nitrite , with observations on the pharmacological action of nitrite : ( section of obstetrics and gynaecology ) . | NA | {
"id": "C0002711",
"name": "amyl nitrite",
"pos": [
32,
44
]
} | {
"id": "C0028137",
"name": "nitrite",
"pos": [
98,
105
]
} |
massive involvement of skull in temporal and occipital regions by carcinoma derived from a rodent ulcer . | NA | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
66,
75
]
} | {
"id": "C0007117",
"name": "rodent ulcer",
"pos": [
91,
103
]
} |
contraction ring : treatment by amyl nitrite , with observations on the pharmacological action of nitrite : ( section of obstetrics and gynaecology ) . | NA | {
"id": "C0002711",
"name": "amyl nitrite",
"pos": [
32,
44
]
} | {
"id": "C0028137",
"name": "nitrite",
"pos": [
98,
105
]
} |
u.v.-irradiated or non-irradiated fibroblasts were infected with either non-irradiated or irradiated ad 2 , and at 48 hours after infection cells were examined for the presence of viral structural antigens ( vag ) using immunofluorescent staining . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
34,
45
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
140,
145
]
} |
u.v.-irradiated or non-irradiated fibroblasts were infected with either non-irradiated or irradiated ad2 , and at 48 hours after infection cells were examined for the presence of viral structural antigens ( vag ) using immunofluorescent staining . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
34,
45
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
139,
144
]
} |
twenty-four pigs were weaned at four weeks of age and fed either spray dried egg albumen ( da ) or autoclaved da ( ada ) as the only protein source were used to evaluate plasma and hepatic parameters as indicators of biotin status . | NA | {
"id": "C0001924",
"name": "da",
"pos": [
91,
93
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
133,
140
]
} |
this is the first evidence that tubular microfibrils both with and without elastin share antigenic determinants and confirms the close antigenic relationship of the zonules to this class of proteins . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
89,
111
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
135,
144
]
} |
the steroid significantly decreased the incorporation of 3h-glucosamine and increased the incorporation of 3h-proline in the outflow pathway cells and in the fibroblasts of the adjacent sclera . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
141,
146
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
158,
169
]
} |
ptosis in both epinephrine- and 6-hydroxydopamine-treated rats was associated with a statistically significant depletion of ocular norepinephrine , as determined by a sensitive catecholamine radio enzyme assay . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
15,
26
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
131,
145
]
} |
in contrast , drug-induced agranulocytosis was more severe , with a higher incidence of positive blood cultures , low cellularity of initial bone marrow aspirates , and a shorter duration of neutropenia . | NA | {
"id": "C0001824",
"name": "agranulocytosis",
"pos": [
27,
42
]
} | {
"id": "C0023530",
"name": "neutropenia",
"pos": [
191,
202
]
} |
this finding is in agreement with other data in the literature which show that many imidazoles , including nitroimidazoles , inhibit aspects of the cell-mediated immune response in animals and man . | NA | {
"id": "C0020924",
"name": "imidazoles",
"pos": [
84,
94
]
} | {
"id": "C0028179",
"name": "nitroimidazoles",
"pos": [
107,
122
]
} |
in this study we have examined pulmonary lavage fluid from fetuses of diabetic and control does for the presence of a surfactant inhibitor , cholesterol content , and phosphatidylcholine ( lecithin ) fatty acid content . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
167,
186
]
} | {
"id": "C0031617",
"name": "lecithin",
"pos": [
189,
197
]
} |
the 3-h cold exposure was associated with a 175 % increase above control levels of norepinephrine ( ne ) and a 100 % increase in epinephrine ( e ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
83,
97
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
129,
140
]
} |
the carbapenem antibiotics , which include the olivanic acids and the thienamycins , have a broad-spectrum of antibacterial activity but only thienamycin itself shows appreciable activity against pseudomonas aeruginosa . | NA | {
"id": "C0006968",
"name": "carbapenem antibiotics",
"pos": [
4,
26
]
} | {
"id": "C0039861",
"name": "thienamycins",
"pos": [
70,
82
]
} |
substrate profile and sensitivity to the beta-lactamase inhibitors , sulbactam , clavulanic acid , cloxacillin , and cefmetazole , a cephamycin derivative , were determined for these enzymes . | NA | {
"id": "C0007550",
"name": "cefmetazole",
"pos": [
117,
128
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
133,
143
]
} |
effect of breed type , feeding level and the two-way interaction upon weight , weight change and feed intake data were initially analyzed . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
70,
76
]
} | {
"id": "C0005911",
"name": "weight change",
"pos": [
79,
92
]
} |
the main effects of breed type and feeding level tended to be significant for weight and weight change in each of the periods . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
78,
84
]
} | {
"id": "C0005911",
"name": "weight change in",
"pos": [
89,
105
]
} |
correlated responses in number born , number born alive , number weaned , birth weight , weaning weight , 13-wk weight and index were evaluated in a guinea pig population after four generations of single trait and index selection for number born alive and 13-wk weight . | NA | {
"id": "C0005612",
"name": "birth",
"pos": [
74,
79
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
262,
268
]
} |
regressions of correlated response on generation number in the 13-wk weight line were all positive , but were significant only for birth weight ( 5.65 +/- .66 g ) and index ( 25.58 +/- 9.90 ) . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
69,
75
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
131,
143
]
} |
in the litter size line , significant responses were found for 13-wk weight ( 21.17 +/- 5.34 g ) and birth weight ( .80 +/- .21 g ) . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
69,
75
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
101,
113
]
} |
the availability of p for ruminal digestion in vivo from a mono-dicalcium phosphate containing 21 % p ( mono-dical ) , a mono-dicalcium phosphate containing 18.5 % p ( dical ) , and defluorinated rock phosphate was compared with sodium phosphate ( na2hpo4 x 7h2o ) . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
74,
83
]
} | {
"id": "C0074757",
"name": "sodium",
"pos": [
229,
235
]
} |
mono-dical , dical and defluorinated rock phosphate were found to be 88 , 62 and 40 % as available as sodium phosphate in the rumen . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
42,
51
]
} | {
"id": "C0074757",
"name": "sodium phosphate",
"pos": [
102,
118
]
} |
compared with sodium phosphate , p from mono-dical , dical and defluorinated rock phosphate was 46.4 , 28.8 and 2.5 % as soluble in an in vitro ruminal buffer . | NA | {
"id": "C0074757",
"name": "sodium phosphate",
"pos": [
14,
30
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
82,
91
]
} |
relative solubilities of the p sources at 1 h were 100 , 71.6 , 41.3 and 29.7 % for sodium phosphate , mono-dical , dical and defluorinated rock phosphate , respectively . | NA | {
"id": "C0074757",
"name": "sodium phosphate",
"pos": [
84,
100
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
145,
154
]
} |
the relationship of structural dimension and efficiency for cows grazing fescue was due to interrelationships of structural dimension , change in cow weight and fatness during lactation , and calf weaning weight : cow weight ratio . | NA | {
"id": "C0005911",
"name": "change in",
"pos": [
136,
145
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
218,
224
]
} |
the above results implied excellent stability to beta-lactamases and this was borne out by the activity of temocillin against strains containing chromosomal cephalosporinases , the 'broad-spectrum ' class iv enzyme and the plasmid mediated enzymes tem-1 , oxa-1 and shv-1 . | NA | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
49,
64
]
} | {
"id": "C0728805",
"name": "cephalosporinases",
"pos": [
157,
174
]
} |
growth curve patterns and regrowth in post antibiotic period of escherichia coli exposed to ampicillin and amoxycillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
92,
102
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
107,
118
]
} |
the growth curve patterns of 8 strains of escherichia coli exposed to amoxycillin or ampicillin were studied in the ms-2 system , which allows an accurate comparison over a wide range of concentrations . | NA | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
70,
81
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
85,
95
]
} |
the maximal value of this residual growth ( mrvg ) was measured for ampicillin and amoxycillin concentrations from 1 to 500 mg/l . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
68,
78
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
83,
94
]
} |
in these experimental conditions the following observations were made : ( a ) the mvrg dropped more rapidly in amoxycillin-treated than in ampicillin-treated cultures . | NA | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
111,
122
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
139,
149
]
} |
( b ) neutralization of antibiotic by beta-lactamase caused a longer lag of regrowth in amoxycillin-treated cultures than in ampicillin-exposed cultures . | NA | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
88,
99
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
125,
135
]
} |
recoveries of 7 additional pesticides ( dimethoate , malathion , methyl parathion , mevinphos , parathion , phorate oxygen analog , and pronamide ) , which were determined by gas-liquid chromatography ( glc ) , averaged 108 % ( range 100-120 ) at the low fortification level and 107 % ( range 99-122 ) at the high fortif... | NA | {
"id": "C0025709",
"name": "methyl parathion",
"pos": [
65,
81
]
} | {
"id": "C0030514",
"name": "parathion",
"pos": [
96,
105
]
} |
efficiency of a urea-acid system was evaluated as a medium of extraction for niacin and niacinamide from cereals and other selected food products . | NA | {
"id": "C0027996",
"name": "niacin",
"pos": [
77,
83
]
} | {
"id": "C0028027",
"name": "niacinamide",
"pos": [
88,
99
]
} |
other experiments show that cytosolic ornithine enters mitochondria readily except when arginine or other basic amino acids are present at high levels in the cells . | NA | {
"id": "C0029277",
"name": "ornithine",
"pos": [
38,
47
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
106,
123
]
} |
other experiments show that cytosolic ornithine enters mitochondria readily except when arginine or other basic amino acids are present at high levels in the cells . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
88,
96
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
106,
123
]
} |
a total of 24 mutants were complemented by the 4.0-kb fragment , 7 were complemented by the 7.7-kb fragment , 9 were complemented by the 4.0-kb fragment plus the 7.7-kb fragment , 15 were complemented by the 10.9-kb fragment , and 25 were complemented by none of the fragments . | NA | {
"id": "C0009524",
"name": "complemented",
"pos": [
27,
39
]
} | {
"id": "C0009498",
"name": "complemented",
"pos": [
239,
251
]
} |
a total of 24 mutants were complemented by the 4.0-kb fragment , 7 were complemented by the 7.7-kb fragment , 9 were complemented by the 4.0-kb fragment plus the 7.7-kb fragment , 15 were complemented by the 10.9-kb fragment , and 25 were complemented by none of the fragments . | NA | {
"id": "C0009526",
"name": "complemented",
"pos": [
27,
39
]
} | {
"id": "C0009498",
"name": "complemented",
"pos": [
239,
251
]
} |
three observations suggest that phosphate and other anions play a role in the in vitro synthesis of lta and its precursors . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
32,
41
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
52,
58
]
} |
macrolide-lincosamide-streptogramin b resistance specified by streptococcus sanguis plasmid pam77 involves an adenine methylase , whose synthesis , demonstrable both phenotypically and by analysis of methionine-labeled proteins made in bacillus subtilis minicells , is inducible by erythromycin , lincomycin , and strept... | NA | {
"id": "C0065002",
"name": "lincosamide",
"pos": [
10,
21
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
297,
307
]
} |
r. capsulata dna fragments that carry loci for production of peptide components of the photosynthetic reaction center and light-harvesting i antenna complex were found to hybridize to dna from some photosynthetic species . | NA | {
"id": "C0012933",
"name": "r",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
184,
187
]
} |
phosphorylation of this ribosomal protein , which exhibits electrophoretic properties similar to those of mammalian ribosomal protein s6 , was also observed in vivo in 32p-labeled zoospores . | NA | {
"id": "C0035552",
"name": "ribosomal protein",
"pos": [
24,
41
]
} | {
"id": "C0073336",
"name": "ribosomal protein s6",
"pos": [
116,
136
]
} |
the insulin cdna was transcribed from the early promoter to produce a stable polyadenylated rna which was translated , and immunoreactive human proinsulin accumulated in the medium . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
4,
11
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
144,
154
]
} |
the keratan sulfate proteoglycans in the combined extracts were purified by a combination of deae-cellulose chromatography , chondroitinase abc digestion to remove chondroitin-dermatan sulfate proteoglycans , and elution from immobilized concanavalin a . | NA | {
"id": "C0033692",
"name": "proteoglycans",
"pos": [
20,
33
]
} | {
"id": "C0033689",
"name": "chondroitin",
"pos": [
164,
175
]
} |
reca protein and circular single-stranded dna form a stable complex in the presence of single-stranded dna binding protein ( ssb ) , in which one reca protein monomer is bound per two nucleotides of dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
26,
45
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
199,
202
]
} |
the results suggest a potential feedback role for bile ductule gamma-glutamyl transpeptidase , in which free bile acids activate the enzyme to catabolize biliary glutathione and thus increase the pool of amino acid precursors required for conjugation ( glycine directly and taurine through cysteine oxidation ) . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
204,
214
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
253,
260
]
} |
in the second system , cholesterol-loaded mouse peritoneal macrophages released cholesterol to hdl in an incubation medium containing 10 to 20 % canine serum . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
23,
34
]
} | {
"id": "C0023822",
"name": "cholesterol",
"pos": [
80,
91
]
} |
the hdl1 and hdlc , which demonstrated slower electrophoretic mobility as determined by geon-pevikon block electrophoresis , became enriched in cholesterol and cholesteryl esters . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
144,
155
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
160,
178
]
} |
when l- [ 35s ] methionine was used as a precursor , 65 to 90 % of the 35s-labeled protein associated with the lipoproteins in the 1.02 to 1.09 density range was immunoprecipitated with antibody directed against rat apo-e . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
83,
90
]
} | {
"id": "C0003601",
"name": "apo-e",
"pos": [
216,
221
]
} |
immunochemical studies demonstrated that the enzyme from both control and 1,25 ( oh ) 2d3-treated cultures cross-reacted with antisera specific for the phosphatase isoenzyme produced by normal human bone , and did not cross-react with antisera specific for the placental alkaline phosphatase isoenzyme . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
45,
51
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
292,
301
]
} |
three protein peaks , not corresponding to known ribosomal proteins , have been observed in preparations from the total protein from 50 s subunits and 70 s ribosomes , but the significance of these peaks is unclear . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
6,
13
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
49,
67
]
} |
the reverse phase high performance liquid chromatography technique has the potential for purifying all ribosomal proteins , as demonstrated by the increase in resolution we obtain when a peak isolated under standard gradient conditions and containing several proteins is reapplied to the column and eluted with a shallow... | NA | {
"id": "C0035552",
"name": "ribosomal",
"pos": [
103,
112
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
259,
267
]
} |
the addition of na+ ion to a total concentration of 0.15 m lowered the cmc in a predictable manner for all anionic bile salts . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
9,
12
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
107,
114
]
} |
the ability of initial transmembrane gradients of either protons or of monovalent cations to promote equivalent changes in internal ph following ionophore addition to sperm suspensions supports application of a simple model that predicts steady state cation distributions . | NA | {
"id": "C0033727",
"name": "protons",
"pos": [
57,
64
]
} | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
71,
89
]
} |
the ability of initial transmembrane gradients of either protons or of monovalent cations to promote equivalent changes in internal ph following ionophore addition to sperm suspensions supports application of a simple model that predicts steady state cation distributions . | NA | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
71,
89
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
251,
257
]
} |
c1in-k complexes were not generated by kaolin in plasma congenitally deficient in hageman factor or prekallikrein or by kallikrein in hereditary angioedema plasma deficient in c1 inactivator , thus confirming the specificity of the assay . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
100,
113
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
120,
130
]
} |
this approximate constancy applies not only to the transport selectivity of the system among neutral amino acids , but also to its tolerance of li+ as a substitute for na+ , its characteristic sensitivity to ph lowering , its relative sensitivity to n-ethylmaleimide , its stimulation by amino acid deprivation , and its... | NA | {
"id": "C0301715",
"name": "neutral amino",
"pos": [
93,
106
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
288,
298
]
} |
the binding of bovine factor v , isolated factor va , and isolated activation intermediates to single bilayer phospholipid vesicles was studied by light scattering . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
22,
30
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
42,
51
]
} |
at saturation , about 35 molecules of factor v and 141 molecules of factor va were bound to each vesicle . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
38,
46
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
68,
77
]
} |
studies of the binding of factor v and factor va at various ionic strengths showed little change in either kd or n , suggesting that the binding is not electrostatic . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
26,
34
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
39,
48
]
} |
the results presented here indicate that the lower kd exhibited by factor v compared to factor va ( components d and e ) is primarily due to the interaction present within the component c portion of the molecule which is destroyed when component c is further cleaved to give component d . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
67,
75
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
88,
97
]
} |
the isoproterenol-treated rat is considered an appropriate model system for studying the overall effects of catecholamine beta-agonists on gene expression in these secretory tissues . | NA | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
4,
17
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
108,
121
]
} |
this microfilament isolation method is applicable to a variety of cell types , including ref-52 cells ( an established rat embryo line ) , l6 myoblasts , 3t3 fibroblasts , chinese hamster ovary cells , baby hamster kidney ( bhk-21 ) cells , mouse neuroblastoma cells , gerbil fibroma cells , and chicken embryo fibroblas... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
96,
101
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
311,
322
]
} |
islet-activating protein ( iap ) , pertussis toxin , is an oligomeric protein ( tamura , m. , nogimori , k. , murai , s. , yajima , m. , ito , k. , katada , t. , ui , m. , and ishii , s. ( 1982 ) biochemistry 21 , 5516-5522 ) , the biggest subunit ( mr = 28,000 , referred to as the a-protomer ) of which catalyzes trans... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
17,
24
]
} | {
"id": "C0025252",
"name": "membrane",
"pos": [
363,
371
]
} |
long chain fatty acids ( 1 mm ) stimulated approximately 1.9-fold [ methyl-3h ] choline incorporation from phosphocholine into phosphatidylcholine by isolated hepatocytes . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
80,
87
]
} | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
107,
121
]
} |
the fatty acyl availability for diglyceride and phospholipid synthesis is restricted to fatty acids longer than myristic acid with octanoic and decanoic acids being excluded . | NA | {
"id": "C0015684",
"name": "fatty",
"pos": [
4,
9
]
} | {
"id": "C0011090",
"name": "decanoic acids",
"pos": [
144,
158
]
} |
thus , the results provide clear evidence that crypticity , as well as antigenicity , of a membrane glycolipid is determined by the degree of sialylation in a second membrane glycoconjugate . | NA | {
"id": "C0017950",
"name": "glycolipid",
"pos": [
100,
110
]
} | {
"id": "C0017906",
"name": "glycoconjugate",
"pos": [
175,
189
]
} |
cytochrome c , fmn , and riboflavin demonstrated different degrees of stimulation of nadph-cytochrome p-450 reductase-dependent denitrosation . | NA | {
"id": "C0016388",
"name": "fmn",
"pos": [
15,
18
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
25,
35
]
} |
of the flavins tested , fmn demonstrated greater stimulation than riboflavin and fad had no observable effect . | NA | {
"id": "C0016213",
"name": "flavins",
"pos": [
7,
14
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
66,
76
]
} |
of the flavins tested , fmn demonstrated greater stimulation than riboflavin and fad had no observable effect . | NA | {
"id": "C0016388",
"name": "fmn",
"pos": [
24,
27
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
66,
76
]
} |
the results demonstrate that the lag phase is induced after the binding of both thiamin diphosphate . mg2+ and pyruvate to the catalytic site to form a ternary enzyme complex , which undergoes subsequently a slow conformational change to an active enzyme form . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
160,
166
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
248,
254
]
} |
electrostatic interactions between anionic substrate and two or more ionic groups on the enzyme have a major role in substrate binding . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
35,
42
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
69,
74
]
} |
from these results it is concluded that t. cruzi epimastigotes possess one single camp-binding protein of monomeric mr = 62,000 , not associated with a phosphotransferase activity and probably very different in nature to known regulatory subunits of protein kinases , given the results obtained with the millipore filtra... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
95,
102
]
} | {
"id": "C0599220",
"name": "subunits",
"pos": [
238,
246
]
} |
it specifically precipitated the enzyme but did not cross-react with the neutral beta-n-acetylglucosaminidase or the acid beta-n-acetylhexosaminidase a and b . | NA | {
"id": "C0001057",
"name": "beta-n-acetylglucosaminidase",
"pos": [
81,
109
]
} | {
"id": "C0005270",
"name": "beta-n-acetylhexosaminidase",
"pos": [
122,
149
]
} |
interestingly , the single site dephosphorylated when calmodulin is bound to myosin light chain kinase is the site that is not phosphorylated when the calmodulin-myosin kinase complex is phosphorylated by camp-dependent protein kinase . | NA | {
"id": "C0027120",
"name": "myosin light chain kinase",
"pos": [
77,
102
]
} | {
"id": "C0006776",
"name": "calmodulin",
"pos": [
151,
161
]
} |
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