text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the biosynthesis of at least 20 soluble mitochondrial polypeptides is enhanced during the adipose conversion of the fibroblasts as determined by polyacrylamide gel electrophoresis following incubation of the cells with [ 35s ] methionine . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
116,
127
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
208,
213
]
} |
of the major mammalian stress proteins ( mr = 72,000 , 73,000 , and 90,000 ) and minor stress proteins ( mr = 80,000 , 100,000 , and 110,000 ) , the 80- and 90-kda proteins were found to be phosphoproteins in all cell types examined . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
30,
38
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
190,
205
]
} |
the tissues next most active/g of wet weight were ovary and adrenal , a finding that is compatible with a special role of hdl in the rat for delivery of cholesterol for steroidogenesis . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
38,
44
]
} | {
"id": "C0037088",
"name": "finding",
"pos": [
72,
79
]
} |
around the time of hatching , the relative rate of synthesis of apo-a1 by chick breast muscle was found to be higher than in liver , a documented major site of synthesis of this apolipoprotein . | NA | {
"id": "C0085201",
"name": "apo-a1",
"pos": [
64,
70
]
} | {
"id": "C0003592",
"name": "a",
"pos": [
178,
179
]
} |
aldosterone-biosynthesizing adrenal tissue contains an angular methyl oxidase which converts corticosterone to 18-hydroxycorticosterone and aldosterone . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
93,
107
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
111,
135
]
} |
the relative distributions , measured by high performance liquid chromatography , of 7 alpha- and 8 alpha-hydroxyriboflavin , riboflavin , and hydroxyethylflavin and its derivative were calculated to be 31.1 , 5.0 , 25.6 , 4.9 , and 21.9 % , respectively , to total flavins in normal human urine obtained in early mornin... | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
113,
123
]
} | {
"id": "C0016213",
"name": "flavins",
"pos": [
266,
273
]
} |
heavy metal derivatives of the galactose binding protein of salmonella typhimurium were obtained by the treatment of crystals with carbon disulfide under anaerobic conditions , followed by exposure to mercury-containing reagents . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
0,
11
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
201,
208
]
} |
however , mapping of tryptic 32p-phosphopeptides by high performance liquid chromatography revealed that epinephrine and insulin stimulated the phosphorylation of 32p-peptides specific for each hormone . | NA | {
"id": "C0031684",
"name": "phosphopeptides",
"pos": [
33,
48
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
167,
175
]
} |
this proteoglycan contained approximately the same percentage of n-linked oligosaccharides as the chondroitin sulfate proteoglycan , but few or no o-linked oligosaccharides . | NA | {
"id": "C0033692",
"name": "proteoglycan",
"pos": [
5,
17
]
} | {
"id": "C0033689",
"name": "chondroitin sulfate proteoglycan",
"pos": [
98,
130
]
} |
the histone composition of the ribosomal gene containing chromatin ( rchromatin ) of the ciliated protozoan tetrahymena pyriformis has been investigated using purified nucleolar fractions in which ribosomal dna constitutes 65-82 % of the total dna . | NA | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
197,
210
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
244,
247
]
} |
the release of adrenaline from the adrenal medullae may also be modulated through facilitatory beta-adrenoreceptors , but the release of noradrenaline from noradrenergic nerves in the central nervous system is not . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
15,
25
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
137,
150
]
} |
this study demonstrates that , in at least one metabolic pathway , the growth-plate chondrocyte does not resemble other normal cells . | NA | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
84,
95
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
120,
132
]
} |
transplantation of human colorectal carcinomas into nude mice offers an excellent experimental in vivo system to study the mechanism of release , metabolism , and excretion of the marker . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
146,
156
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
163,
172
]
} |
opened-up substrate-attached membranes of chick fibroblasts as well as detergent-permeabilized cells were treated with fragmin from physarum in the presence of ca+2 . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
48,
59
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
95,
100
]
} |
the markers used to follow the ontogeny of epithelial layer formation include ssea-1 , l , and i blood group antigens , laminin , fibronectin , type iv collagen , cytoskeletal intermediate filament proteins ( vimentin , endo a , and b ) , and afp . | NA | {
"id": "C0021769",
"name": "intermediate filament",
"pos": [
176,
197
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
209,
217
]
} |
the involvement of the microtubules is indicated by the fact that enhancement of the dna synthetic response was demonstrated with the chemically diverse agents colchicine , nocodazole , vinblastine , or demecolcine , all of which elicited the response in a dose-dependent manner . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
160,
170
]
} | {
"id": "C0011259",
"name": "demecolcine",
"pos": [
203,
214
]
} |
incubation of chicken skeletal muscle fibers with an excess of anti-m-creatine kinase ( ck ) immunoglobulin g and an excess of anti-m-ck fab fragments leads to heavy decoration of the m-line ( wallimann , t. , d.c . | NA | {
"id": "C0010291",
"name": "m-creatine",
"pos": [
68,
78
]
} | {
"id": "C0010287",
"name": "ck",
"pos": [
134,
136
]
} |
it is concluded that the muscle-specific form of creatine kinase , mm-ck , contributes mainly to the electron density of these m4 and m4 ' m-bridges within the m-line structure . | NA | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
49,
64
]
} | {
"id": "C0010291",
"name": "mm-ck",
"pos": [
67,
72
]
} |
heparan sulfate glycosaminoglycan , isolated from the cell surface of nonadhering murine myeloma cells ( p3x63-ag8653 ) , does not bind to plasma fibronectin , but binds partially to collagen type i , as assayed by affinity chromatography with proteins immobilized on cyanogen bromide-activated sepharose 4b . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
0,
15
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
16,
33
]
} |
the nature of 12-o-tetradecanoylphorbol-13-acetate ( tpa ) -stimulated hemopoiesis , colony stimulating factor ( csf ) requirement for colony formation , and the effect of tpa on [ 125i ] csf-1 binding to macrophages . | NA | {
"id": "C0009392",
"name": "colony stimulating factor",
"pos": [
85,
110
]
} | {
"id": "C0079784",
"name": "csf-1",
"pos": [
188,
193
]
} |
the tumor-promoting phorbol diester , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) was found to act both independently of and synergistically with the mononuclear phagocyte specific colony stimulating factor ( csf-1 ) to stimulate the formation of macrophage colonies in cultures of mouse bone marrow cells . | NA | {
"id": "C0009392",
"name": "colony stimulating factor",
"pos": [
182,
207
]
} | {
"id": "C0079784",
"name": "csf-1",
"pos": [
210,
215
]
} |
in contrast , tpa did not synergize with other csf subclasses that stimulate the formation of eosinophil , eosinophil-neutrophil , neutrophil , neutrophil-macrophage , and macrophage colonies , nor with either of the two factors required for megakaryocyte colony formation , megakaryocyte csf , and megakaryocyte colony ... | NA | {
"id": "C0009392",
"name": "csf",
"pos": [
47,
50
]
} | {
"id": "C0040052",
"name": "megakaryocyte csf",
"pos": [
275,
292
]
} |
it also induced a transient prereplicative increase in the activities of a nuclear ca2+-calmodulin-stimulable , protamine-phosphorylating protein kinase , and a nuclear poly ( l-lysine ) -phosphorylating , 105 kda protein kinase . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
75,
82
]
} | {
"id": "C0033603",
"name": "protamine",
"pos": [
112,
121
]
} |
thyroparathyroidectomy ( tptx ) delayed and reduced the first surge and completely eliminated the second surge of both of the cytoplasmic cyclic amp-dependent protein kinases , reduced the rises in the activity of nuclear catalytic subunits , and completely eliminated the surge of the ca2+-calmodulin-stimulable protein... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
159,
166
]
} | {
"id": "C0028589",
"name": "nuclear",
"pos": [
366,
373
]
} |
one intraperitoneal injection of 1,25-dihydroxyvitamin d1 into tptx rats immediately after hpx completely restored the post-hpx surges in the activity of type i cyclic amp-dependent protein kinase , but the hormone , even in high doses , had little or not effect on the type ii isoenzyme or the nuclear ca2+-calmodulin-s... | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
278,
287
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
358,
364
]
} |
early and late precursor cells ( erythroid burst-forming units ; bfu-e and colony-forming units ; cfu-e , respectively ) were evaluated by the ability of bone marrow and spleen cells to form colonies of fully differentiated erythroid cells in vitro . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
15,
30
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
234,
239
]
} |
the phorbol ester tumor promoter 12-o-tetradecanoylphorbol-13-acetate ( tpa ) and the calcium ionophore , a23187 , have similar effects on many different cells . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
4,
17
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
33,
69
]
} |
csf-1 is a hemopoietic growth factor that specifically regulates the survival , proliferation , and differentiation of mononuclear phagocytic cells . | NA | {
"id": "C0009392",
"name": "csf-1",
"pos": [
0,
5
]
} | {
"id": "C0021757",
"name": "hemopoietic growth factor",
"pos": [
11,
36
]
} |
significant correlations were observed between the cell donor 's bmi and the concentration of insulin required to inhibit half of the [ 125i ] insulin specifically bound to fibroblasts ( r = 0.8 ; p less than 0.005 ) , the high affinity dissociation constant ( r = 0.8 ; p less than 0.005 ) , and the number of receptors... | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
51,
55
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
173,
184
]
} |
these data suggest that the 19,000- to 20,000- and 26,000- to 30,000-dalton human neurophysins represent stable proteins which are probably common precursor molecules for neurophysin and avp , but the greater than 30,000-dalton neurophysins found in the v0 appear to be aggregates of neurophysins , neurophysin precursor... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
112,
120
]
} | {
"id": "C0033665",
"name": "precursor proteins",
"pos": [
429,
447
]
} |
the endocrine profile in peripheral blood revealed markedly increased plasma androstenedione concentrations but normal testosterone , dihydrotestosterone , progesterone , 17-hydroxyprogesterone , and dehydroepiandrosterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
156,
168
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
171,
193
]
} |
to evaluate the possibility that a specific biosynthetic pathway deficiency exists in hyperreninemic hypoaldosteronism ( hh ) , basal and acth-stimulated levels of aldosterone and its immediate precursors 18-hydroxycorticosterone ( 18-ohb ) and corticosterone ( b ) were determined in eight hh patients , six critically ... | NA | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
205,
229
]
} | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
245,
259
]
} |
furthermore , the correlation between both beta lph and beta ep with dhas plasma levels in prepuberty suggests a role of proopiocortin-related peptides in adrenarche . | NA | {
"id": "C0023832",
"name": "beta lph",
"pos": [
43,
51
]
} | {
"id": "C0033195",
"name": "proopiocortin",
"pos": [
121,
134
]
} |
serial analysis of circulating immune complexes , complement , and antithymocyte globulin antibodies in heart transplant recipients . | NA | {
"id": "C0003313",
"name": "circulating immune complexes",
"pos": [
19,
47
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
90,
100
]
} |
thirteen heart transplant patients receiving heterologous antithymocyte globulin were examined serially for the presence of circulating immune complexes , activation of complement , and antibodies to antithymocyte globulin . | NA | {
"id": "C0003313",
"name": "circulating immune complexes",
"pos": [
124,
152
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
186,
196
]
} |
two patients had increased proportions of cells identified by a monoclonal antibody to a subpopulation of t lymphocytes which includes suppressor t cells ( okt8 ) , and their cells were able to suppress immunoglobulin biosynthesis by peripheral blood mononuclear cells from normal donors . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
42,
47
]
} | {
"id": "C1321301",
"name": "peripheral",
"pos": [
234,
244
]
} |
other proteins ( ovalbumin , rabbit albumin , human albumin , and gelatin ) were equally effective competitors for adsorption sites on plastic . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
6,
14
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
52,
59
]
} |
other proteins ( ovalbumin , rabbit albumin , human albumin , and gelatin ) were equally effective competitors for adsorption sites on plastic . | NA | {
"id": "C0029923",
"name": "ovalbumin",
"pos": [
17,
26
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
52,
59
]
} |
other proteins ( ovalbumin , rabbit albumin , human albumin , and gelatin ) were equally effective competitors for adsorption sites on plastic . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
19,
26
]
} | {
"id": "C0304925",
"name": "human albumin",
"pos": [
46,
59
]
} |
that vitamin k1 enhances the benzo ( a ) pyrene effect while warfarin and vitamin k deficiency inhibit benzo ( a ) pyrene tumorigenesis indicates that vitamin k1 , vitamin k deprivation , or possibly blockade of its metabolic cycle also modulates benzo ( a ) pyrene metabolism in vivo but by a mechanism or at a site dif... | NA | {
"id": "C0042878",
"name": "vitamin k",
"pos": [
5,
14
]
} | {
"id": "C0025270",
"name": "vitamin k3",
"pos": [
336,
346
]
} |
in the absence of insulin , rates of accumulation in media of triglycerides , apo-b , apo-c-iii3 , and apo-e were 2.5 +/- 0.3 micrograms/mg and 33 +/- 5 , 24 +/- 3 , and 162 +/- 32 ng/mg cell protein per h , respectively . | NA | {
"id": "C0003601",
"name": "apo",
"pos": [
78,
81
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
192,
199
]
} |
exposure of fibroblast populations to mononuclear cell products may , thus , lead to metabolite alterations that are still evident after multiple cell generations . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
12,
22
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
146,
150
]
} |
cardiac norepinephrine ( ne ) turnover was used to assess sympathetic nervous system ( sns ) activity , and urinary excretion of epinephrine ( e ) was measured as an index of adrenal medullary activity . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
8,
22
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
129,
140
]
} |
in clonal cultures of erythroid burst-forming units ( bfu-e ) obtained from blood , the accumulation of fetal and adult hemoglobins ( hb f and hb a ) was measured by radioligand immunoassay . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
134,
138
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
143,
145
]
} |
the differential effect on hb f and hb a accumulation was achieved without altering the maturity of the erythroid cells , their mean hemoglobin content , or the asynchrony of the production of the two hemoglobins . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
27,
31
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
201,
212
]
} |
radioiodinated lp ( a ) and ldl were injected intravenously into 12 normolipemic individuals to measure kinetic parameters of these two lipoproteins simultaneously in each subject . | NA | {
"id": "C0065058",
"name": "lp ( a",
"pos": [
15,
21
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
136,
148
]
} |
transferrin and ferritin-specific immunoabsorption and also gel filtration established that no other soluble iron binding proteins were involved in absorption . | NA | {
"id": "C0015879",
"name": "ferritin",
"pos": [
16,
24
]
} | {
"id": "C1135611",
"name": "iron",
"pos": [
109,
113
]
} |
we propose a model of mammalian distal nephron acidification in which ( a ) cellular base exit is effected by means of a basolateral membrane cl-base exchanger and ( b ) net electroneutrality of electrogenic proton secretion is maintained by the parallel movement of an anionic species , functionally chloride . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
270,
277
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
301,
309
]
} |
tissue somatostatin-like immunoreactivity ( sli ) consists of a number of molecular species including the cyclic tetradecapeptide or srif , an n-terminally extended form of srif termed somatostatin-28 , as well as larger precursor peptides . | NA | {
"id": "C0037659",
"name": "srif",
"pos": [
133,
137
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
185,
200
]
} |
ampicillin was also found to be more active than amoxycillin against citrobacter freundii and serratia marcescens . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
0,
10
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
49,
60
]
} |
in view of these findings , the practice of using ampicillin discs to predict sensitivity to amoxycillin should be reconsidered . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
50,
60
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
93,
104
]
} |
the use of both ampicillin and amoxycillin discs is appropriate if errors are to be avoided . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
16,
26
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
31,
42
]
} |
acquired udst may occur coincident with physiologic states of estrogen increase , including puberty and pregnancy in women and adrenarche in men . | NA | {
"id": "C2916830",
"name": "physiologic states",
"pos": [
40,
58
]
} | {
"id": "C0034011",
"name": "puberty",
"pos": [
92,
99
]
} |
acquired udst may occur coincident with physiologic states of estrogen increase , including puberty and pregnancy in women and adrenarche in men . | NA | {
"id": "C2916830",
"name": "physiologic states",
"pos": [
40,
58
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
104,
113
]
} |
kasabach-merritt syndrome consists of thrombocytopenia , microangiopathic hemolytic anemia , and an acute or chronic consumption coagulopathy in association with a rapidly enlarging hemangioma . | NA | {
"id": "C0221025",
"name": "kasabach-merritt syndrome",
"pos": [
0,
25
]
} | {
"id": "C0018916",
"name": "hemangioma",
"pos": [
182,
192
]
} |
sebum secretion was measured by absorption of skin surface lipid into bentonite clay and estimation of the amount of absorbed sebum by measurement of its wax ester component . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
59,
64
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
154,
157
]
} |
at that point , the percent of cationic proteins and neural proteins decreased with a concurrent increase in anionic migrating proteins . | NA | {
"id": "C0027759",
"name": "neural",
"pos": [
53,
59
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
127,
135
]
} |
changes in the morphology of the oxidation zone and the quantities of oxide for gold alloys containing two base metals ( in and sn ) were investigated by exposing alloys at 1000 degrees c for one h in air . | NA | {
"id": "C0018027",
"name": "gold alloys",
"pos": [
80,
91
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
163,
169
]
} |
a case of verrucous carcinoma with a focus of cytologically malignant squamous-cell carcinoma is presented . | NA | {
"id": "C0206706",
"name": "verrucous carcinoma",
"pos": [
10,
29
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
84,
93
]
} |
one minute later , technetium-99m labeled microspheres were injected into the left atrium for assessment of the hypoperfused zone ( the zone at risk of infarction ) . | NA | {
"id": "C0022116",
"name": "hypoperfused",
"pos": [
112,
124
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
152,
162
]
} |
the more severe the dyssynergy , the higher the qrs score ( hypokinesia = 3.0 ; akinesia = 5.4 ; dyskinesia = 9.1 ) . | NA | {
"id": "C0004134",
"name": "dyssynergy",
"pos": [
20,
30
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
97,
107
]
} |
the more severe the dyssynergy , the higher the qrs score ( hypokinesia = 3.0 ; akinesia = 5.4 ; dyskinesia = 9.1 ) . | NA | {
"id": "C0086439",
"name": "hypokinesia",
"pos": [
60,
71
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
97,
107
]
} |
during maximal supine exercise , plasma norepinephrine and epinephrine concentrations increased three to six times more than during either symptom-limited handgrip or cold pressor testing . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
40,
54
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
59,
70
]
} |
dermatophagoides farinae ( df 80d ) and dermatophagoides pteronyssinus ( dp 80d ) extracts were analyzed for their antigenic and allergenic composition by means of crossed immunoelectrophoresis ( cie ) and crossed radioimmunoelectrophoresis ( crie ) . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
115,
124
]
} | {
"id": "C0002092",
"name": "allergenic",
"pos": [
129,
139
]
} |
among the antigens of d. farinae and d. pteronyssinus , only the antigen corresponding to df 5 and dp 5 seems to bear common epitopes to the two mite species , whereas df 6 and dp 4 appear to bear , respectively , specific epitopes of each species . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
10,
17
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
223,
231
]
} |
moreover , we observed that for one antigen ( antigen 5 ) there exist antigenic determinants common to the two species of mites toward the rabbit serum and specific allergenic determinants to the human ige response . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
36,
43
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
70,
92
]
} |
pronounced hepatomegaly observed at 1500 and 3000 ppm was associated with histological alterations such as cellular hypertrophy , cytoplasmic vacuolisation and focal necrosis . | NA | {
"id": "C0019209",
"name": "hepatomegaly",
"pos": [
11,
23
]
} | {
"id": "C0020564",
"name": "hypertrophy",
"pos": [
116,
127
]
} |
fetal blood lactate and plasma corticosteroids also increased , but at slower rates and other fetal hormone concentrations were unchanged . | NA | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
31,
46
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
100,
107
]
} |
through use of oxidation and blockading reactions , chemical group precursors of aldehyde demonstrable with schiff reaction staining were identified in the soluble lipid-free lipofuscin component of neuromelanin of human substantia nigra and in lipofuscin of human inferior olive . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
164,
169
]
} | {
"id": "C0023789",
"name": "lipofuscin",
"pos": [
245,
255
]
} |
the most active cephalosporin was the cephamycin derivative cefoxitin that inhibited 98 % of strains at 16 mg/l which corresponds with the usual median serum level achieved at commonly recommended treatment regimens . | NA | {
"id": "C3536856",
"name": "cephalosporin",
"pos": [
16,
29
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
38,
48
]
} |
the most active cephalosporin was the cephamycin derivative cefoxitin that inhibited 98 % of strains at 16 mg/l which corresponds with the usual median serum level achieved at commonly recommended treatment regimens . | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
38,
48
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
60,
69
]
} |
the protease is immunogenic and has , in toxoid form , been used experimentally in a multicomponent vaccine . | NA | {
"id": "C0040555",
"name": "toxoid",
"pos": [
41,
47
]
} | {
"id": "C0042210",
"name": "vaccine",
"pos": [
100,
107
]
} |
we have found that an immunomodulator , dextran , prevents initiation of tolerance for an unrelated haptenic stimulus of contact hypersensitivity , picryl chloride . | NA | {
"id": "C0018593",
"name": "haptenic",
"pos": [
100,
108
]
} | {
"id": "C0031891",
"name": "picryl chloride",
"pos": [
148,
163
]
} |
the relationship of b cell proliferation and the generation of immunoglobulin-secreting cells ( isc ) was explored in vitro by examining the effect of hydroxyurea ( hu ) , an inhibitor of cellular dna synthesis , on the generation of isc from human peripheral blood mononuclear cells ( pbm ) . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
188,
196
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
249,
283
]
} |
stimulator cell dilution studies revealed an eightfold greater allogeneic lymphocyte-stimulating potency for epidermal cells when compared to autologous peripheral blood mononuclear cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
11,
15
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
153,
187
]
} |
taken together , these results suggest that antibodies to antigenic determinants on the leu-2 and leu-3 molecules competitively block segments of these structures that bind to alloantigen or nominal antigen . | NA | {
"id": "C0003316",
"name": "antigenic",
"pos": [
58,
67
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
199,
206
]
} |
the natural conformation of this antigen appears to be 95,000 in m.w . with the 58,000 particle containing the sm antigenic determinant . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
33,
40
]
} | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
114,
135
]
} |
further comparison of four representative hybridoma antibodies with antisera having specificity for art antigens by indirect immunofluorescence demonstrated that two of the three patterns corresponded to anti-art-1a and anti-art-2a specificities . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
52,
62
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
68,
76
]
} |
this antiserum ( anti-zx ) had agglutinating activity on rabbit erythrocytes reacted with quail antibody and quail complement ( eacq ) but not on eaq , and developed two precipitin lines against quail serum at beta- and gamma-regions in crossed immunoelectrophoresis . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
5,
14
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
96,
104
]
} |
furthermore , the 184k protein in serum was cleaved through the incubation with inulin to 174k and 140k proteins that might correspond to c3b and c3c of human complement ; | NA | {
"id": "C0009511",
"name": "c3b",
"pos": [
138,
141
]
} | {
"id": "C0009514",
"name": "c3c",
"pos": [
146,
149
]
} |
furthermore antigen-antibody complexes may be efficiently disrupted with 9 m urea and non-ionic detergent and both antibody and antigen renatured by removal of urea , antibody regaining the ability to bind fresh antigen . | NA | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
12,
38
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
167,
175
]
} |
a method is also described to enrich for functional antibody from immune precipitates by dissociating antibody-antigen complexes with 9 m urea and 1 % nonidet p-40 and isolating the antigen free antibody on staphylococcus aureus cowan strain a . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
52,
60
]
} | {
"id": "C0003313",
"name": "antibody-antigen complexes",
"pos": [
102,
128
]
} |
cells were either ( 1 ) reacted with specific antisera to cell surface determinants and panned over a plates , cells with antibody on their surface binding to the monolayer , or ( 2 ) panned over a plates to which specific antibody had been coupled . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
46,
54
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
223,
231
]
} |
the elisa detected an ama directed against one determinant of a mitochondrial antigen bearing the characteristics of the so-called pbc antigen ( m2 antigen ) . | NA | {
"id": "C0003316",
"name": "determinant",
"pos": [
47,
58
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
148,
155
]
} |
elisa antibodies were detected from the third week of the disease while neutralizing antibodies appeared after 5 weeks . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
6,
16
]
} | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
72,
95
]
} |
two monoclonal antibodies are then added either separately or simultaneously , and the amount of bound antibody is quantitatively measured by use of immunoglobulin ( rabbit anti-mouse igg ) linked to beta-galactosidase . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
4,
25
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
103,
111
]
} |
sera from 7 patients with pemphigus vulgaris and both mouse and rabbit antisera against bovine epidermal desmosomes contained antibodies that bound to cell surface components of the spinous layer of bovine epidermis . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
71,
79
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
126,
136
]
} |
pemphigus sera that reacted with desmosomal proteins in elisa were absorbed by affinity chromatography on immobilized desmosomal proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
44,
52
]
} | {
"id": "C2350558",
"name": "immobilized",
"pos": [
106,
117
]
} |
the relative potency order of stimulation of adenylate cyclase was : isoproterenol greater than epinephrine much greater than norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
96,
107
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
126,
140
]
} |
a series of monoclonal antibodies to human epidermal transglutaminase is being prepared to allow detailed analysis of its structural activation and detection of common antigenic sites among transglutaminase that may be masked or not present in conventional antibodies to the enzyme . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
12,
33
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
257,
267
]
} |
one-micron histologic sections of the original biopsy specimens revealed no striking site-related keratinocyte alterations , but sun-exposed specimens had fewer epidermal langerhans cells ( p less than 0.001 ) , averaging approximately 50 percent the number in sun-protected skin , a possible exaggeration of the previou... | NA | {
"id": "C0022567",
"name": "alterations",
"pos": [
111,
122
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
365,
369
]
} |
only 30 % of the cord blood specimens tested demonstrated normal lysis of hsv-1-infected fibroblasts and a normal increment in the lysis of infected over uninfected cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
89,
100
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
107,
113
]
} |
individual women usually ( 94 % ) maintained constant titers of antibodies to ebv-specific antigens , including viral capsid antigen , early antigen , and ebv-associated nuclear antigen . | NA | {
"id": "C0003342",
"name": "viral",
"pos": [
112,
117
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
178,
185
]
} |
[ comparative test of the effectiveness of netilmicin and sisomicin on respiratory tract infection by double blind method ] . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
43,
53
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
58,
67
]
} |
by electron microscopic examinations , at 12 weeks after the injury , cells in the repaired tissue were indistinguishable from chondrocytes , and the tidemark showed a fine structure similar to that in the articular cartilage in controls where many electron dense particles were observed . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
70,
75
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
127,
139
]
} |
a small fraction of gssg-r activity is essential for platelet function , and bcnu provides a powerful new tool to investigate the role of the enzymatic reduction of glutathione in platelet physiology and pathology . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
20,
24
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
165,
176
]
} |
the alpha subunits formed crosslinks with spectrin in the absence of exogenous hydrogen peroxide , whereas both the beta subunit and the intact hemoglobin molecule required a minimum of 40 and 4 microm peroxide , respectively , in order to form these crosslinks . | NA | {
"id": "C0020281",
"name": "hydrogen",
"pos": [
79,
87
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
202,
210
]
} |
this study suggests that dmso can inhibit metabolism of other sulfoxides in man and may antagonize the therapeutic efficacy of sulindac . | NA | {
"id": "C0012403",
"name": "dmso",
"pos": [
25,
29
]
} | {
"id": "C0038771",
"name": "sulfoxides",
"pos": [
62,
72
]
} |
the percentage of dietary cholesterol absorbed was calculated by dividing the rate of appearance of exogenous cholesterol radioactivity in lymph by the rate of infusion of dietary cholesterol radioactivity at a time when lymph cholesterol specific activity was constant relative to that of diet . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
18,
37
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
227,
238
]
} |
our data demonstrated that there was not a simple one-to-one relationship between the amount of isotopic dietary cholesterol absorbed from the intestinal lumen and the mass of cholesterol moved into lymph via the intestine . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
105,
124
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
176,
187
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.