text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
cholesteryl oleate was the predominant cholesteryl ester present in lymph d less than 1.006 g/ml lipoproteins and it was the predominant cholesteryl ester formed from exogenous radiolabeled cholesterol . | NA | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
39,
56
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
190,
201
]
} |
although estrogen did not affect the concentrations of free or esterified cholesterol in the liver , the hormone increased the amount of cholesterol esterified with 20-carbon fatty acids and caused a corresponding decrease in cholesterol esterified with 18 carbon fatty acids . | NA | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
63,
85
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
226,
237
]
} |
using specific radioimmunoassays for human apolipoproteins a-i and a-ii , the major apoproteins of high density lipoproteins , for apolipoproteins c-ii and c-iii , major apoproteins of very low density lipoproteins , and for apolipoprotein b , the major apoprotein of low density lipoproteins , we found immunoreactivity... | NA | {
"id": "C0003593",
"name": "apolipoprotein b",
"pos": [
225,
241
]
} | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
336,
351
]
} |
using specific radioimmunoassays for human apolipoproteins a-i and a-ii , the major apoproteins of high density lipoproteins , for apolipoproteins c-ii and c-iii , major apoproteins of very low density lipoproteins , and for apolipoprotein b , the major apoprotein of low density lipoproteins , we found immunoreactivity... | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
84,
94
]
} | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
336,
351
]
} |
acylcoenzyme a : cholesterol acyltransferase ( acat ) activity in jejunum and ileum was decreased significantly in animals fed the plant sterol alone . | NA | {
"id": "C0008380",
"name": "cholesterol acyltransferase",
"pos": [
17,
44
]
} | {
"id": "C0001390",
"name": "acat",
"pos": [
47,
51
]
} |
mathur . beta-sitosterol : esterification by intestinal acylcoenzyme a : cholesterol acyltransferase ( acat ) and its effect on cholesterol esterification . | NA | {
"id": "C0008380",
"name": "cholesterol acyltransferase",
"pos": [
73,
100
]
} | {
"id": "C0001390",
"name": "acat",
"pos": [
103,
107
]
} |
effect of removal of lipoproteins of different composition on hepatic 3-hydroxy-3-methylglutaryl coenzyme a reductase activity and hepatic very low density lipoprotein secretion . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
21,
33
]
} | {
"id": "C0023825",
"name": "very low",
"pos": [
139,
147
]
} |
to explore the role of triglycerides further , the effect of these lipoprotein particles on vldl secretion was determined . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
67,
78
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
92,
96
]
} |
effect of removal of lipoproteins of different composition on hepatic 3-hydroxy-3-methylglutaryl coenzyme a reductase activity and hepatic very low density lipoprotein secretion . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
21,
33
]
} | {
"id": "C0023825",
"name": "very low density lipoprotein",
"pos": [
139,
167
]
} |
mass spectra have been obtained on molecular species of intact diacyl phosphatidylcholine by means of ammonia gas-induced chemical ionization . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
102,
109
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
110,
113
]
} |
a retrospective study was conducted to define the incidence of ventricular ectopic beats with exit block ( concealed extrasystoles ) . | NA | {
"id": "C0151636",
"name": "ventricular",
"pos": [
63,
74
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
117,
130
]
} |
of 53 holters reviewed for parasystole 12 were suggestive of , and five indicated this dysrhythmia . | NA | {
"id": "C0206068",
"name": "parasystole",
"pos": [
27,
38
]
} | {
"id": "C0003811",
"name": "dysrhythmia",
"pos": [
87,
98
]
} |
collectively , these data provide evidence that the hla-d region contains at least six loci encoding distinct alpha and beta chains for the hla-sb , hla-dr , and hla-ds molecules . | NA | {
"id": "C0019754",
"name": "hla-d",
"pos": [
52,
57
]
} | {
"id": "C0019759",
"name": "hla-sb",
"pos": [
140,
146
]
} |
collectively , these data provide evidence that the hla-d region contains at least six loci encoding distinct alpha and beta chains for the hla-sb , hla-dr , and hla-ds molecules . | NA | {
"id": "C0019754",
"name": "hla-d",
"pos": [
52,
57
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
149,
155
]
} |
collectively , these data provide evidence that the hla-d region contains at least six loci encoding distinct alpha and beta chains for the hla-sb , hla-dr , and hla-ds molecules . | NA | {
"id": "C0019754",
"name": "hla-d",
"pos": [
52,
57
]
} | {
"id": "C0019761",
"name": "hla-ds",
"pos": [
162,
168
]
} |
covalently , cross-linked immune complexes were prepared with multivalent 2-nitro-4-azidophenyl x human serum albumin ( nap x hsa ) and antibodies to nap at five times antigen excess . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
26,
42
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
136,
146
]
} |
antibody plus complement treatment , using a monoclonal antibody that recognizes an antigen present on nk cells , removed much of the cytotoxic activity , and a density gradient fraction enriched for nk cells yielded cells of increased virus-specific cytotoxicity . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
45,
64
]
} |
the ab1 ' antibodies differed from balb/c ab1 by lower relative binding to five of eight tested dex , and by expressing the igh4b allotype determinants on the igg1 antibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
10,
20
]
} | {
"id": "C0021006",
"name": "allotype",
"pos": [
130,
138
]
} |
one provides major histocompatibility complex-restricted help for plaque-forming cell responses by drw 1+ allogeneic b cells ; | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
81,
85
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
106,
116
]
} |
we have used panels of monoclonal antibodies to circumsporozoite ( cs ) proteins of plasmodium falciparium , p. vivax , and p. knowlesi to determine the number of topographically independent epitopes of these antigens . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
191,
199
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
209,
217
]
} |
further analysis of these clones suggests ( a ) that the allo i-ad mhc epitopes recognized by these clones are not shared with self-i-a epitopes , ( b ) that the virus or bp antigens do not cross-react with dba/2 minor h antigens , ( c ) that these clones recognize different determinants on the dba/2 minor h antigens ,... | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
71,
79
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
437,
445
]
} |
the simultaneous determination of the catalytic activities in serum of monoamine oxidase ( ec 1.4.3.4 ) and n-acetyl-beta-d-glucosaminidase ( ec 3.2.1.30 ) was performed in patients with various non-liver diseases , acute hepatitis and fibroproliferative liver disorders ( cirrhosis and fibrosis ) and the predictive val... | NA | {
"id": "C0023895",
"name": "liver disorders",
"pos": [
255,
270
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
273,
282
]
} |
it was found that the incidence of the positive result is extremely low ( 0.024 , 5/207 ) in patients suffering from a great variety of non-liver and liver diseases ( except cirrhosis ) but rather great in liver cirrhotic subjects ( 0.44 , 18/41 ) . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
150,
164
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
174,
183
]
} |
a gaschromatographic method is presented for the determination of thiopental ( and of its metabolite pentobarbital ) in cases of severe head injuries treated by induction of therapeutic barbiturate coma . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
101,
114
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
186,
197
]
} |
a procedure is described for the determination of the following 19 metabolites in 200 mg gastrocnemius muscle from guinea pig : glucose 1-phosphate and 6-phosphate , fructose 6-phosphate , fructose 1,6-bisphosphate , glyceraldehyde 3-phosphate , dihydroxyacetone phosphate , 3-phospho- and 2-phosphoglyceric acid , phosp... | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
422,
430
]
} | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
433,
451
]
} |
current data document appreciable alterations in the metabolism or excretion of warfarin , theophylline , phenytoin , lidocaine , certain beta-adrenoceptor antagonists , certain benzodiazepines , and probably narcotic analgesics and procainamide . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
53,
63
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
67,
76
]
} |
reaction product in the secretory tubules was localized coincident with that reported for sodium-potassium activated adenosine triphosphatase ( na-k-atpase ) : along the highly amplified basolateral plasma membranes of the epithelial cells . | NA | {
"id": "C0001473",
"name": "adenosine triphosphatase",
"pos": [
117,
141
]
} | {
"id": "C0001479",
"name": "na-k-atpase",
"pos": [
144,
155
]
} |
serotonin or its agonist 5-methoxytryptamine can stimulate hamster sperm acrosome reactions in a more direct manner than catecholamines . | NA | {
"id": "C0036751",
"name": "serotonin",
"pos": [
0,
9
]
} | {
"id": "C0000589",
"name": "methoxytryptamine",
"pos": [
27,
44
]
} |
serotonin ( 50 microm ) or its agonist 5-methoxytryptamine ( 5 microm ) stimulated the acrosome reactions of golden hamster sperm within 15 min after addition to sperm capacitated in vitro for 4.5 h . | NA | {
"id": "C0036751",
"name": "serotonin",
"pos": [
0,
9
]
} | {
"id": "C0000589",
"name": "methoxytryptamine",
"pos": [
41,
58
]
} |
epinephrine ( 70 microm ) , norepinephrine ( 50 microm ) , and dopamine ( 25 microm ) were unable to stimulate acrosome reactions even at 30 min under the same conditions , even though previous studies had demonstrated stimulation by these catecholamines at the same concentrations when present from the start of the cap... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
28,
42
]
} |
antibody-induced patching of the viral antigens did not result in co-patching of the thy-1.1 antigens . | NA | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
33,
47
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
93,
101
]
} |
these results may help to explain apparent discrepancies previously reported between experiments utilizing direct binding of igg proteins and those using rosetting of antibody-coated srbc to examine fc receptor properties and indicate that immune complexes of virus and antibody resemble aggregated immunoglobulins with ... | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
240,
256
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
379,
387
]
} |
in addition , viral messenger rna activity was found to be associated only with non-polyadenylated rna species when assayed in an in vitro translation system . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
20,
33
]
} | {
"id": "C0035668",
"name": "non-polyadenylated rna",
"pos": [
80,
102
]
} |
analysis by hybridization and oligonucleotide mapping showed that the two larger duplexes contained complementary ( c ) rnas that were transcribed from the l and m segments of viral rna while the crnas contained in the two smaller duplexes were both transcribed from the s rna segment . | NA | {
"id": "C0035736",
"name": "viral",
"pos": [
176,
181
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
273,
276
]
} |
the virus-induced enzyme was partially purified , free of the constitutive cell isozyme , by fractionation of infected cell extracts with ammonium sulphate . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
18,
24
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
80,
87
]
} |
these results demonstrate that the virus-induced enzyme differs antigenically , as well as biochemically , from the constitutive cell isozyme and lend further support to the hypothesis that the enzyme is virus-coded . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
134,
141
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
194,
200
]
} |
in the context of a review of adult cases of gender disturbance , a clinical study was pursued on the status of fathers , father-substitutes , and older male siblings for 46 boys with deviations in male role development . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
45,
51
]
} | {
"id": "C0086582",
"name": "male",
"pos": [
198,
202
]
} |
significantly fewer male role models were found in the family backgrounds of the severely gender-disturbed boys as compared to the mild-to-moderately gender-disturbed boys . | NA | {
"id": "C0086582",
"name": "male",
"pos": [
20,
24
]
} | {
"id": "C0079399",
"name": "gender",
"pos": [
150,
156
]
} |
contrary to prediction , loading rats with tryptamine , tryptophan or methanol failed to produce any rise in endogenous monoamine oxidase inhibitor output , whilst ethanol administration resulted in a significantly decreased excretion . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
70,
78
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
164,
171
]
} |
these groups of slowly transported proteins are therefore similar to those transported much more slowly in other mammalian nerves , with the exception that no proteins with molecular weight similar to the neurofilament proteins could be detected . | NA | {
"id": "C0007292",
"name": "transported proteins",
"pos": [
23,
43
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
219,
227
]
} |
for example , the glycine content of the substantia nigra , which is believed to utilize this amino acid as a neurotransmitter , decreased preictally . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
18,
25
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
94,
99
]
} |
comparison with the fluorescence spectrum of the bovine brain s100-a ' protein ( alpha'beta ) , which contains a tryptophan residue in the alpha ' subunit , enables us to demonstrate that the recent report describing an abnormal fluorescence spectrum for the bovine brain s100-b protein may result from a contamination o... | NA | {
"id": "C3658228",
"name": "s100-b protein",
"pos": [
272,
286
]
} | {
"id": "C0027758",
"name": "s100",
"pos": [
340,
344
]
} |
a diagnosis of chronic asymmetrical spinal muscular atrophy , as opposed to that of classical motor neurone disease , is favoured by an age of onset under 40 years , an absence of pyramidal signs or bulbar involvement after 3 years or more of symptoms , and depressed or absent tendon reflexes . | NA | {
"id": "C0026847",
"name": "spinal muscular atrophy",
"pos": [
36,
59
]
} | {
"id": "C0085084",
"name": "motor neurone disease",
"pos": [
94,
115
]
} |
these ultrastructural changes are compared and correlated with the reports of clinical manifestations of rhabdomyolysis and myoglobinuria . | NA | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
105,
119
]
} | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
124,
137
]
} |
because the abnormalities persist for the 7 day duration of these observations , and because many of these were observed in the pre-marathon biopsies , we conclude that both the intensive training for , and the marathon itself , induce inflammation and fiber necrosis which are manifested in the clinical symptoms for rh... | NA | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
318,
332
]
} | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
337,
350
]
} |
at autopsy , spongiform encephalopathy was demonstrated , and inoculation of brain tissue into 4 squirrel monkeys and 1 capuchin monkey resulted in the development of kuru . | NA | {
"id": "C0162534",
"name": "spongiform encephalopathy",
"pos": [
13,
38
]
} | {
"id": "C0022802",
"name": "kuru",
"pos": [
167,
171
]
} |
pathological changes of the cerebral arteries were studied in 30 dogs after subarachnoid injections of saline , fresh autologous blood , epinephrine , blood plus epinephrine , norepinephrine , or blood plus norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
137,
148
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
207,
221
]
} |
blood plus epinephrine produced marked changes in the internal elastic lamina and tortuosities of the nuclei of smooth-muscle cells , while norepinephrine and blood plus norepinephrine produced only minor changes . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
11,
22
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
170,
184
]
} |
the magnitude of bf within individual tumor foci generally could be related to tumor size , location ( intraparenchymal versus extraparenchymal ) , and the presence of necrosis or cysts ; | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
38,
43
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
180,
185
]
} |
after a 1-wk course of hyperalimentation with albumin , furosemide , and protein , repeat radiographs showed reduction in bowel gas . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
46,
53
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
73,
80
]
} |
serum albumin , protein , total and high density lipoprotein ( hdl ) -cholesterol , triglyceride , urinary and liver ascorbic acid , liver cholesterol and total lipids were increased in rats fed pcb . | NA | {
"id": "C0023822",
"name": "high",
"pos": [
36,
40
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
139,
150
]
} |
serum total cholesterol and low density lipoprotein ( ldl ) plus very low density lipoprotein ( vldl ) -cholesterol , and liver total lipids , and cholesterol were significantly higher , and serum hdl-cholesterol and triglyceride were significantly lower in the cholesterol-fed group as compared to pcb-fed rats . | NA | {
"id": "C0023826",
"name": "very low density lipoprotein",
"pos": [
65,
93
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
262,
273
]
} |
addition of km to a cholesterol diet significantly depressed serum total cholesterol and ldl plus vldl-cholesterol , liver cholesterol and total lipids . | NA | {
"id": "C0023826",
"name": "vldl-cholesterol",
"pos": [
98,
114
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
123,
134
]
} |
the relative biological value ( rbv ) of iron in egg yolk was compared with that of iron in ferrous sulfate in prophylactic assays with weanling rats . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
41,
45
]
} | {
"id": "C0060282",
"name": "ferrous sulfate",
"pos": [
92,
107
]
} |
response of dietary iron was calculated as the regression of hemoglobin iron gain on iron intake and the nutritional quality of egg iron relative to that of ferrous sulfate iron was evaluated by slope-ratio analysis . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
20,
24
]
} | {
"id": "C0060282",
"name": "ferrous sulfate iron",
"pos": [
157,
177
]
} |
the presence of ascorbic acid during heat treatment of the diets significantly increased rbv of yolk iron from 64 to 92 % in experiment 2 , and increased it to a value equivalent to that of ferrous sulfate in experiment 3 . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
101,
105
]
} | {
"id": "C0060282",
"name": "ferrous sulfate",
"pos": [
190,
205
]
} |
rabbits were fed three semipurified diets , namely a cholesterol-free soy protein diet , a cholesterol-free casein diet or a diet containing soy protein plus cholesterol ( 2 g/kg ) . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
53,
64
]
} | {
"id": "C0008395",
"name": "diet",
"pos": [
125,
129
]
} |
chronic catheters were implanted 8 weeks postpartum and 7 experiments were performed on these nonlactating vitamin b-12-depleted sheep ( de-b12 : 340 +/- 30 ng vitamin b-12 per gram wet liver ) prior to repletion by intramuscular injection of hydroxocobalamin . | NA | {
"id": "C0042845",
"name": "vitamin b-12",
"pos": [
107,
119
]
} | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
243,
259
]
} |
in addition , liver copper levels were significantly affected by both dietary selenium and liver glycogen content indicating a significant copper-selenium and copper-glycogen interaction in trout . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
91,
105
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
166,
174
]
} |
these results showed that overall , entry of riboflavin into hepatocytes occurs predominantly by a facilitated diffusion process followed by rapid trapping by flavokinase-catalyzed phosphorylation to fmn . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
45,
55
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
200,
203
]
} |
this organism occurs in high numbers in periodontitis lesions of patients with localized juvenile periodontitis ( periodontosis ) . | NA | {
"id": "C0031099",
"name": "periodontitis",
"pos": [
40,
53
]
} | {
"id": "C0031106",
"name": "periodontosis",
"pos": [
114,
127
]
} |
xylazine , another alpha 2-agonist , which , unlike both clonidine and phentolamine , is not a substituted 2-imidazoline compound , failed to enhance the response in the bladder to nanc nerve stimulation . | NA | {
"id": "C0009014",
"name": "clonidine",
"pos": [
57,
66
]
} | {
"id": "C1449836",
"name": "imidazoline",
"pos": [
109,
120
]
} |
the incidence of headache pain was twice as high in the cmd group than in the comparison group ( p less than .001 ) . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
17,
25
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
26,
30
]
} |
thirty-three patients with headache pain were treated for a 4-week period with occlusal splint therapy . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
27,
35
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
36,
40
]
} |
radiological , and particularly arteriographic examinations in a 28-year-old man investigated for a malabsorption syndrome with exsudative enteropathy demonstrated the presence of a complex anomaly of mesenteric artery and vein vascularization . | NA | {
"id": "C0024523",
"name": "malabsorption syndrome",
"pos": [
100,
122
]
} | {
"id": "C0021831",
"name": "enteropathy",
"pos": [
139,
150
]
} |
ca2+ -antagonist drugs can be divided into three main classes based on their interaction with the 3h-nim binding site : class i has one site law of mass action-displacement isotherms with 3h-nim , class ii exhibits complex biphasic inhibition profiles and class iii drugs increase the affinity of 1,4 dihydropyridines fo... | NA | {
"id": "C0028094",
"name": "3h-nim",
"pos": [
98,
104
]
} | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
301,
317
]
} |
3'-amino-2',3'-dideoxyribonucleosides of thymine , uracil , and 5-iodouracil ( 1-3 ) were synthesized from the corresponding 2'-deoxyribonucleosides via the threo-3'-chloro and the erythro-3'-azido derivatives . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
41,
48
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
70,
76
]
} |
sodium-chloride transport in the medullary thick ascending limb of henle 's loop : evidence for a sodium-chloride cotransport system in plasma membrane vesicles . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
7,
15
]
} | {
"id": "C0037494",
"name": "sodium-chloride",
"pos": [
98,
113
]
} |
the stimulation of sodium uptake by chloride was seen in the presence of a chloride gradient directed into the vesicle and when the vesicles were equilibrated with nacl , kcl plus valinomycin so that no chemical or electrical gradients existed across the vesicle ( tracer exchange experiments ) . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
36,
44
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
164,
168
]
} |
apart from its rather long repeat unit , the characteristics of this dna appear to be quite similar to those of complex satellite dnas from other organisms . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
69,
72
]
} | {
"id": "C0012934",
"name": "satellite dnas",
"pos": [
120,
134
]
} |
the 2.4 x 10 ( 3 ) nucleotide rna , which is the same size as the previously identified surface antigen messenger rna , hybridized with probes covering the surface antigen gene but not with probes corresponding to the core antigen gene . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
30,
33
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
104,
117
]
} |
if the transmembrane dimension of a protein hydrophobic surface differs from the equilibrium thickness of its lipid bilayer environment , will protein monomers aggregate to decrease the protein-lipid contact surface area ? | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
36,
43
]
} | {
"id": "C0025252",
"name": "protein",
"pos": [
186,
193
]
} |
the conformations of some related oligoribonucleotides in solution were investigated immunochemically with antisera specific for two synthetic oligonucleotide sequences , a-a-u and a-a-u-u . | NA | {
"id": "C0028956",
"name": "oligoribonucleotides",
"pos": [
34,
54
]
} | {
"id": "C0028953",
"name": "oligonucleotide",
"pos": [
143,
158
]
} |
in a concentration-dependent fashion oleate activated or inhibited the ( ca2+ + mg2+ ) -atpase , or ca2+ pump atpase , of membranes isolated from human red blood cells ( rbc 's ) . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
88,
94
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
100,
103
]
} |
in cases with repeated epileptic convulsions , numerous fibrous astrocytes were seen in the affected portion of the gray matter , suggesting that they were the results of the repeated convulsions . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
23,
32
]
} | {
"id": "C0036572",
"name": "convulsions",
"pos": [
184,
195
]
} |
the pharmacokinetics of lidocaine in dogs were investigated following the intravenous and intramuscular administration of single doses of lidocaine hydrochloride . | NA | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
24,
33
]
} | {
"id": "C0546869",
"name": "lidocaine",
"pos": [
138,
147
]
} |
these latter proteins migrated with apparent molecular weights of 52k , 50k , 48.5k , 45k , 37.5k , and 35k , and all were phosphoproteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
13,
21
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
123,
138
]
} |
a molecularly cloned fragment of amphotroph dna was ligated to the 2.4-kilobase-pair f-mulv dna , and an 8.3-kilobase-pair hybrid f-mulv-amphotroph dna was subcloned into a new plasmid ( p5a25-h ) . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
148,
151
]
} |
the gene d5 product ( gpd5 ) of bacteriophage t5 is a dna-binding protein that binds preferentially to double-stranded dna and is essential for t5 dna replication , yet it inhibits dna synthesis in vitro . | NA | {
"id": "C0033684",
"name": "gene",
"pos": [
4,
8
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
54,
73
]
} |
however , in c57bl lmg , substantial amounts of mumtv rna were present , whereas very little viral rna was detected in balb/c lmg . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
54,
57
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
93,
102
]
} |
no viral proteins were detected in run-off reactions that permit completion of nascent polypeptide synthesis with polysomes from c57bl lmg , and sensitive radioimmunoassays failed to detect any mumtv proteins in these tissues . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
3,
17
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
200,
208
]
} |
precursor polyproteins containing translational products of the gag gene of moloney murine leukemia virus were purified by gel electrophoresis and cleaved into large fragments by hydroxylamine , mild acid hydrolysis , or cyanogen bromide . | NA | {
"id": "C0032583",
"name": "polyproteins",
"pos": [
10,
22
]
} | {
"id": "C0017279",
"name": "products",
"pos": [
48,
56
]
} |
this assay was based upon our previous observation that the fraction of herpesviral dna-binding protein which can be eluted from nuclei with dnase i represents proteins associated with progeny viral dna ( d . | NA | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
84,
103
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
160,
168
]
} |
we also present supportive evidence for the binding of the wild-type protein to intracellular viral dna by showing that a monoclonal antibody coprecipitated virus-specific dna sequences with the major dna-binding protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
69,
76
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
201,
220
]
} |
although an initiation codon is located early ( codon 4 ) in the open reading frame , it is likely that splicing yields an mrna on which translation initiates at the same aug as that of the gag gene to produce a nascent polypeptide in which gp85 is preceded by a 62-amino-acid-long leader peptide . | NA | {
"id": "C0242610",
"name": "initiation codon",
"pos": [
12,
28
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
48,
53
]
} |
both the prototype strain and the immunosuppressive strain grow in and form plaques on monolayers of simian virus 40-transformed human fibroblasts , a finding that has allowed the comparison of several aspects of their virus-host cell interactions . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
135,
146
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
230,
234
]
} |
therapy of the second tumor depends on the interval between the 2 tumors as well as on histologic differentiation of the second tumor . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
66,
72
]
} | {
"id": "C0085183",
"name": "second tumor",
"pos": [
121,
133
]
} |
chromatin with nascent ribonuclear protein ( rnp ) fibers representing transcription of ribosomal dna ( top ) and nonribosomal dna ( bottom ) . | NA | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
88,
101
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
127,
130
]
} |
this observation led us to determine the maximal amounts of calcium and phosphate that can be added to parenteral nutrition solutions without the precipitation of calcium phosphate and to determine the optimal ratio of calcium to phosphate in these solutions . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
60,
67
]
} | {
"id": "C0006711",
"name": "calcium",
"pos": [
219,
226
]
} |
however , experience with long-term total parenteral nutrition in preterm infants , awareness of the acute and life-threatening effects of body phosphate depletion , and an unmeasured endogenous enteric calcium secretion all suggest that a ca/p ratio of approximately 3.0 provides a safer compromise between the acute an... | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
203,
210
]
} | {
"id": "C0006711",
"name": "ca/p",
"pos": [
240,
244
]
} |
in order to investigate sudden cardiac death at exertion ( sports , and light work in daily life ) , 226 cases of sudden death during sports and 1,729 autopsy cases of sudden death were studied , and exercise tests were performed on 138 patients with various cardiac diseases . | NA | {
"id": "C0085298",
"name": "sudden cardiac death",
"pos": [
24,
44
]
} | {
"id": "C0011071",
"name": "sudden death",
"pos": [
168,
180
]
} |
this study was designed to investigate the relationships of myocardial concentrations of norepinephrine ( ne ) and cyclic amp ( c-amp ) to the development of ventricular fibrillation ( vf ) with reference to the effects of a premedication of dibutyryl cyclic amp ( dbc-amp ) and propranolol in dogs with experimental myo... | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
115,
125
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
242,
262
]
} |
in dogs premedicated with dbc-amp an increase of c-amp was observed in both the ischemic and the non-ischemic zones in association with an increased incidence of vf . | NA | {
"id": "C0012054",
"name": "dbc-amp",
"pos": [
26,
33
]
} | {
"id": "C0001455",
"name": "c-amp",
"pos": [
49,
54
]
} |
the clinical effects of antibiotics ( lincomycin , cefotaxime , ceftizoxime , piperacillin , fosfomycin , cefmenoxime , cefotetan , cefbuperazone , cefpiramide and ceftazidime ) were evaluated in gynecologic infections . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
51,
61
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
64,
75
]
} |
the clinical effects of antibiotics ( lincomycin , cefotaxime , ceftizoxime , piperacillin , fosfomycin , cefmenoxime , cefotetan , cefbuperazone , cefpiramide and ceftazidime ) were evaluated in gynecologic infections . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
51,
61
]
} | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
106,
117
]
} |
during the period from may through july 1981 , a comparative study was carried out on the antibacterial activities of cefotaxime ( ctx ) and ceftizoxime ( czx ) , cefoperazone ( cpz ) , latamoxef ( lmox ) , cefotiam ( ctm ) , cefmetazole ( cmz ) and cefazolin ( cez ) . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
118,
128
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
141,
152
]
} |
during the period from may through july 1981 , a comparative study was carried out on the antibacterial activities of cefotaxime ( ctx ) and ceftizoxime ( czx ) , cefoperazone ( cpz ) , latamoxef ( lmox ) , cefotiam ( ctm ) , cefmetazole ( cmz ) and cefazolin ( cez ) . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
118,
128
]
} | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
207,
215
]
} |
with regard to gram-negative bacteria , ctx and czx showed the best antibacterial activities for all of the species , except for p. aeruginosa . | NA | {
"id": "C0007554",
"name": "ctx",
"pos": [
40,
43
]
} | {
"id": "C0007560",
"name": "czx",
"pos": [
48,
51
]
} |
all of the 65 strains were inhibited by low concentration of rifampicin , metronidazole , vancomycin , ampicillin and amoxicillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
103,
113
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
118,
129
]
} |
wide variations in susceptibility of c. difficile strains to erythromycin , clindamycin and lincomycin were found . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
76,
87
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
92,
102
]
} |
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