text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the results indicates that the kidney can inactivate angiotensin and that high doses of angiotensin ii can produce myocardial and renal lesions . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
53,
64
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
88,
102
]
} |
cardiac myxoma arises from multipotential mesenchymal cells in the endocardium of the atrial septum which may develop into smooth muscle cells , fibroblasts , cartilage cells and endotherial cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
145,
156
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
191,
196
]
} |
both ocular and pulmonary lesions were observed to respond well to treatment with corticosteroid hormone . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
82,
96
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
97,
104
]
} |
the most common side effects included fever , chills , asthenia , anorexia , and weight loss , and leukopenia , granulocytopenia , and lymphopenia occurred frequently . | NA | {
"id": "C0023530",
"name": "leukopenia",
"pos": [
99,
109
]
} | {
"id": "C0001824",
"name": "granulocytopenia",
"pos": [
112,
128
]
} |
the contractility of the right atrium , a heart region known to be unaffected by ischemia , was studied in rats with experimental left ventricular infarction . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
81,
89
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
147,
157
]
} |
in particular , the role played by axonal transport in the course of diseases of the optic nerve ( papilledema ) , elevation of iop and retinopathies with vascular origins is summarized . | NA | {
"id": "C0029132",
"name": "the",
"pos": [
16,
19
]
} | {
"id": "C0030353",
"name": "papilledema",
"pos": [
99,
110
]
} |
the 6-hour exposure to head-down tilt at -- 15 degrees was accompanied by an increased blood content of adrenaline and noradrenaline , thus indicating the activation of the sympathoadrenal system . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
104,
114
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
119,
132
]
} |
the exposure also led to an increase of the content of serotonin and left the content of 5-hydroxytryptophan , tryptophan , histamine and histidine unchanged . | NA | {
"id": "C0000578",
"name": "hydroxytryptophan",
"pos": [
91,
108
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
111,
121
]
} |
traces of three nitrosamines ( n-nitrosodimethylamine , n-nitrosodipropylamine , and n-nitrosomorpholine ) were found in a single sample of ain-76 mineral mix . | NA | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
16,
28
]
} | {
"id": "C0012431",
"name": "n-nitrosodimethylamine",
"pos": [
31,
53
]
} |
( b ) in immunodiffusion , the predominant amyloid fibril protein from wal isolated in pure form from formalin-fixed tissues precipitated in a line of identity with anti-aa and a purified and chemically identified protein aa from another patient . | NA | {
"id": "C1456454",
"name": "amyloid",
"pos": [
43,
50
]
} | {
"id": "C0002716",
"name": "aa",
"pos": [
222,
224
]
} |
( c ) amyloid fibril protein from wal had a molecular weight of 8000 to 9000 in sodium dodecyl sulfate polyacrylamide gel electrophoresis and , thus , is in the same range as the commonly found protein aa . | NA | {
"id": "C1456454",
"name": "amyloid",
"pos": [
6,
13
]
} | {
"id": "C0002716",
"name": "aa",
"pos": [
202,
204
]
} |
comparison of 3h- and 125i-radioimmunoassay and gas chromatography/mass spectrometry for the determination of delta 9-tetrahydrocannabinol and cannabinoids in blood and serum . | NA | {
"id": "C0039663",
"name": "delta 9-tetrahydrocannabinol",
"pos": [
110,
138
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
143,
155
]
} |
rats were injected s.c. with clomiphene ( cl ) , zuclomiphene ( zuc ) or enclomiphene ( enc ) on days 1,3 , and 5 of life and the stimulation of the reproductive tract and estrogen receptor binding was observed . | NA | {
"id": "C0009008",
"name": "clomiphene",
"pos": [
29,
39
]
} | {
"id": "C0087182",
"name": "zuclomiphene",
"pos": [
49,
61
]
} |
rats were injected s.c. with clomiphene ( cl ) , zuclomiphene ( zuc ) or enclomiphene ( enc ) on days 1,3 , and 5 of life and the stimulation of the reproductive tract and estrogen receptor binding was observed . | NA | {
"id": "C0009008",
"name": "clomiphene",
"pos": [
29,
39
]
} | {
"id": "C0086213",
"name": "enclomiphene",
"pos": [
73,
85
]
} |
uterine weight and dna content were increased significantly by day 7 in animals treated with clomiphene or zuclomiphene . | NA | {
"id": "C0009008",
"name": "clomiphene",
"pos": [
93,
103
]
} | {
"id": "C0087182",
"name": "zuclomiphene",
"pos": [
107,
119
]
} |
uterine epithelial hypertrophy was present in all groups by day 10 and hyperplasia was present in the animals treated with zuc and cl . | NA | {
"id": "C0087182",
"name": "zuc",
"pos": [
123,
126
]
} | {
"id": "C0009008",
"name": "cl",
"pos": [
131,
133
]
} |
the binding of estrogen in preparations of human peripheral blood mononuclear cells , as well as by splenic and thymic cells is demonstrated by three different approaches ( dextran-coated charcoal method , whole cell assay , and gel filtration on a sepharose 4b column ) . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear",
"pos": [
49,
77
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
119,
124
]
} |
when products were analysed in the incubation of deoxycorticosterone with the mitochondrial suspension containing a larger amount of cytochrome p-450 , the formation of 18-hydroxycorticosterone was observed in addition to the formation of corticosterone and 18-hydroxy-11-deoxycorticosterone . | NA | {
"id": "C0011710",
"name": "deoxycorticosterone",
"pos": [
49,
68
]
} | {
"id": "C0000173",
"name": "18-hydroxy-11-deoxycorticosterone",
"pos": [
258,
291
]
} |
when products were analysed in the incubation of deoxycorticosterone with the mitochondrial suspension containing a larger amount of cytochrome p-450 , the formation of 18-hydroxycorticosterone was observed in addition to the formation of corticosterone and 18-hydroxy-11-deoxycorticosterone . | NA | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
169,
193
]
} | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
277,
291
]
} |
the result suggests that the pathway via 18-hydroxy-11-deoxycorticosterone substantially participates in the formation of 18-hydroxycorticosterone from deoxycorticosterone . | NA | {
"id": "C0000173",
"name": "18-hydroxy-11-deoxycorticosterone",
"pos": [
41,
74
]
} | {
"id": "C0011710",
"name": "deoxycorticosterone",
"pos": [
152,
171
]
} |
the perturbation of this network by an artificial means , such as the addition of triton x-100 , revealed that the detergent ( 0.02 % ) facilitated the production of 18-hydroxycorticosterone from deoxycorticosterone , regardless of its inhibitory effect on the production of corticosterone and 18-hydroxy-11-deoxycortico... | NA | {
"id": "C0011710",
"name": "deoxycorticosterone",
"pos": [
196,
215
]
} | {
"id": "C0000173",
"name": "18-hydroxy-11-deoxycorticosterone",
"pos": [
294,
327
]
} |
determination of prostaglandin e2 and the main prostaglandin e metabolite by micro high-performance liquid chromatography using fluorescence derivatization with dansyl hydrazine . | NA | {
"id": "C0012472",
"name": "prostaglandin e2",
"pos": [
17,
33
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
47,
62
]
} |
a micro high-performance liquid chromatographic method for the determination of prostaglandin e2 ( pge2 ) and the main prostaglandin e metabolite ( pgemt ) in rat organs and human urine has been developed . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
99,
103
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
119,
134
]
} |
the standard deviation of the method was +/- 6.5 % for pge2 , and +/- 8.4 % for pgemt . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
55,
59
]
} | {
"id": "C0033559",
"name": "pgemt",
"pos": [
80,
85
]
} |
the detection and simultaneous quantitation of less than 10 ng of pge2 and pgemt is possible . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
66,
70
]
} | {
"id": "C0033559",
"name": "pgemt",
"pos": [
75,
80
]
} |
the proposed method is suitable for the pharmacological analysis of pge2 and pgemt in various rat tissues and human urine . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
68,
72
]
} | {
"id": "C0033559",
"name": "pgemt",
"pos": [
77,
82
]
} |
on the other hand , a diphenylhydantoin-induced increase in the total number of specific benzodiazepine binding sites seems of minor importance since clonazepam ( with a high affinity for these sites ) and chlordiazepoxide ( with a low affinity ) were equipotent in the enhancement of the combined treatment efficacy . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
89,
103
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
206,
222
]
} |
( c5-c9 ) f-aa may be involved in the pathogenesis of idiopathic addison 's disease and may be regarded as a marker for individuals in whom idiopathic adrenal insufficiency is likely to develop . | NA | {
"id": "C0001403",
"name": "addison 's disease",
"pos": [
65,
83
]
} | {
"id": "C0001623",
"name": "adrenal insufficiency",
"pos": [
151,
172
]
} |
hla type and islet cell antibody status in family with ( diabetes insipidus and mellitus , optic atrophy , and deafness ) didmoad syndrome . | NA | {
"id": "C0011848",
"name": "diabetes insipidus",
"pos": [
57,
75
]
} | {
"id": "C0043207",
"name": "didmoad syndrome",
"pos": [
122,
138
]
} |
the proportion of open neural-tube defects ( ontd ) terminated as a result of serum screening was 56.1 % ( 66.6 % for anencephaly and 40.7 % for open spina bifida ) . | NA | {
"id": "C0027794",
"name": "neural-tube defects",
"pos": [
23,
42
]
} | {
"id": "C0002902",
"name": "anencephaly",
"pos": [
118,
129
]
} |
tolerance to morphine and dadl was determined by inhibition to the tail flick response after intrathecal administration of cumulative doses of morphine sulfate and dadl . | NA | {
"id": "C0026549",
"name": "morphine",
"pos": [
13,
21
]
} | {
"id": "C0066814",
"name": "morphine sulfate",
"pos": [
143,
159
]
} |
the results indicate that there exists two separate types of opioid receptor , mu- and delta-opioid receptor in the spinal cord of rats . | NA | {
"id": "C0034801",
"name": "opioid receptor",
"pos": [
61,
76
]
} | {
"id": "C0140057",
"name": "delta-opioid receptor",
"pos": [
87,
108
]
} |
dose-related alterations in the levels of prostaglandins ( pgf2 alpha and pge ) and thromboxane b2 ( txb2 ) were observed in the urine of unanesthetized rats following whole-body gamma radiation . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
42,
56
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
74,
77
]
} |
various postulated indices of central dopaminergic activity - cerebrospinal fluid ( csf ) dopamine ( da ) , dihydroxy-phenylacetic acid ( dopac ) , homovanillic acid ( hva ) , noradrenaline ( na ) , plasma na , serum prolactin , serum dopamine-hydroxylase ( dbh ) , and platelet monoamine oxidase ( mao ) activity - were... | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
38,
50
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
235,
243
]
} |
the labeling of choline glycerophospholipid ( cgp ) from radioactive cytidine-5'-diphosphate choline ( cdp-choline ) in vitro shows a maximum at ph 8.0 ( using hepes [ 4- ( 2-hydroxyethyl ) -piperazine-1-ethane-2-sulfonic acid ] as a buffer ) and is stimulated by mn2+ , mg2+ and diacylglycerol . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
16,
23
]
} | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
103,
114
]
} |
to determine the physiochemical behavior of xenobiotic hydrocarbons in simulated intestinal content , we examined the partition of 7,12-dimethylbenzanthracene ( dmba ) , 3-methyl cholanthrene ( mc ) , benzo ( a ) pyrene , and a polychlorinated biphenyl compound ( pcb , aroclor 1242 ) between an emulsified oil phase and... | NA | {
"id": "C0005580",
"name": "biphenyl compound",
"pos": [
244,
261
]
} | {
"id": "C0032447",
"name": "pcb",
"pos": [
264,
267
]
} |
the occurrence rate of an unfavorable outcome as determined by histological evidence of cirrhosis was 6 % versus 44 % ( p less than 0.01 ) in carriers with active viral infection ( greater than 1 ng/ml of hbv-dna ) and in patients with absent or low levels of viral dna ( less than 1 pg/ml ) , respectively . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
209,
212
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
260,
269
]
} |
finally , monoclonal antibodies open up lines of investigation , such as the examination of correlations between the monoclonal antibody 's inhibition of t-cell proliferation and the antibody 's corresponding ia epitope-binding characteristics , that it would be impossible to approach using conventional alloantisera . | NA | {
"id": "C0003250",
"name": "monoclonal antibody 's",
"pos": [
117,
139
]
} | {
"id": "C0003241",
"name": "antibody 's",
"pos": [
183,
194
]
} |
it was found that ( i ) modifications of the nucleotide sequence , apart from the commonly accepted promoter region , both upstream and downstream of the rna initiation point greatly influenced the efficiency of promoters in vivo , ( ii ) a recombinant dna composed of one of the promoter-probe plasmids and a tandem of ... | NA | {
"id": "C0012931",
"name": "recombinant dna",
"pos": [
241,
256
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
422,
425
]
} |
it was found that ( i ) modifications of the nucleotide sequence , apart from the commonly accepted promoter region , both upstream and downstream of the rna initiation point greatly influenced the efficiency of promoters in vivo , ( ii ) a recombinant dna composed of one of the promoter-probe plasmids and a tandem of ... | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
253,
256
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
424,
425
]
} |
after incubation of 32p-labeled linear dna ( form iii ) with bromouracil-labeled circular dna ( form i-form ii mixture ) in the presence of reca protein , mg++ and atp , about 10 % of the 32p-counts band at an intermediate density in cscl equilibrium gradient . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
39,
42
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
81,
93
]
} |
the suppression of cell-division lasted for six generations whether markers near the origin ( gln , ilv ) or terminus ( his , trp ) of chromosome replication were used , despite a 50-fold difference in transduction frequencies for these markers . | NA | {
"id": "C0017393",
"name": "markers",
"pos": [
68,
75
]
} | {
"id": "C0005516",
"name": "markers",
"pos": [
237,
244
]
} |
these results are interpreted to suggest that the recf pathway directs integration of single-stranded hfr dna into the recipient chromosome whereas the recbc pathway catalyses the exchange of largely double stranded dna . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
86,
101
]
} | {
"id": "C0012854",
"name": "double stranded dna",
"pos": [
200,
219
]
} |
the lipid content of salmonella typhimurium was examined after growth in the presence of benzylpenicillin , ampicillin , mecillinam and tetracycline in nutrient broth and a defined medium with either glucose , acetate or glycerol as the sole carbon source . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
89,
105
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
108,
118
]
} |
oligopeptides bind nearly equally well to both enzymes , and a peptide chloromethylketone is much more reactive to thiolsubtilisin than to subtilisin . | NA | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
0,
13
]
} | {
"id": "C0030956",
"name": "peptide",
"pos": [
63,
70
]
} |
the suspension of intact rhizobium lupini bacteroids in phosphate buffer solution ph 7.8 was shown to catalyse the biosynthesis from sucrose and ammonium of some amino acids , such as alanine , aspartic and glutamic acids , glycine and serine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
162,
173
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
184,
191
]
} |
the suspension of intact rhizobium lupini bacteroids in phosphate buffer solution ph 7.8 was shown to catalyse the biosynthesis from sucrose and ammonium of some amino acids , such as alanine , aspartic and glutamic acids , glycine and serine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
162,
173
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
224,
231
]
} |
the yield of alanine and aspartic acid was 2.5-3 times higher than that of other amino acids , which were formed in almost equal quantities . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
13,
20
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
81,
92
]
} |
two types of dna fragments attached to the nuclear skeleton and protected from staphylococcal nuclease digestion by the nuclear skeleton 's proteins were found in ehrlich ascites carcinoma cells : ( i ) long ( approximately 10 kb ) satellite dna fragments and ( ii ) short ( approximately 140 b. p. ) main band dna fragm... | NA | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
232,
245
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
311,
314
]
} |
regulation of human histone gene expression : kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mrnas during the hela cell cycle . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
46,
54
]
} | {
"id": "C0018517",
"name": "half-lives",
"pos": [
119,
129
]
} |
the protein binds equally well to form i dna of phi x174 or the plasmid pbr322 , but has a higher affinity for a hybrid plasmid containing a cloned region of drosophila melanogaster satellite dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
41,
44
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
194,
195
]
} |
the amount of the metabolically active uracil pool , estimated as 11 pmol/10 ( 7 ) heterotrophically growing cells , decreased to almost zero during light-induced rna synthesis and could be changed by preloading with uracil or thymine . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
39,
45
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
227,
234
]
} |
the earliest responses of cellular rna metabolism to adenovirus infection were , however , the rapid and apparently coordinate reductions in the levels of newly synthesized 28s rrna and cellular mrna sequences entering the cytoplasm . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
35,
38
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
177,
181
]
} |
sparse cultures of fibroblasts that assemble only minimal amounts of extracellular matrix were extracted under mild conditions with triton x-100 which remove most of the lipids and soluble cellular proteins . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
19,
30
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
189,
197
]
} |
blot hybridization analysis of dna from micrococcal nuclease digests of erythrocyte nuclei showed that 5s dna has the same average nucleosome repeat length , 192 +/- 4 base pairs , as two xenopus satellite dnas and bulk erythrocyte chromatin . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
31,
34
]
} | {
"id": "C0012934",
"name": "satellite dnas",
"pos": [
196,
210
]
} |
the binding of antibody was also tested by cross linking with paraformaldehyde : dopamine , serotonin , tryptamine , 5-methoxytryptamine etc. , to serum albumin . | NA | {
"id": "C0036751",
"name": "serotonin",
"pos": [
92,
101
]
} | {
"id": "C0000589",
"name": "5-methoxytryptamine",
"pos": [
117,
136
]
} |
in order to answer the question whether these proteins are associated with igm and/or igd ig-complexes were separated with regard to their isotype and analyzed separately by 2d-sds-page . | NA | {
"id": "C0020843",
"name": "igd",
"pos": [
86,
89
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
139,
146
]
} |
ih the 88 children with congenital heart defects , and in 20 with an extreme left-axis deviation previous to surgery , an angle of -60 degrees to -90 degrees was found , most often in children with complete a-v canals of down 's syndrome ( as well as in children with transposition of the great arteries , univentricular... | NA | {
"id": "C0040761",
"name": "transposition of the great arteries",
"pos": [
268,
303
]
} | {
"id": "C0018798",
"name": "malformations of the heart",
"pos": [
348,
374
]
} |
aging of skeletal muscle in the hindleg of the mouse is accompanied by a progressive increase in the amount of the interstitial tissue and especially that of lipid cells and fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
164,
169
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
174,
185
]
} |
optimal hydrolysis of aluronate oligosaccharides was observed at ph 3.0 for trisaccharide and ph 2.0 for tetra- and hexasaccharide , respectively . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
32,
48
]
} | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
76,
89
]
} |
persistent pulmonary hypertension of the newborn is a syndrome consisting of severe hypoxemia and pulmonary hypertension that appears within hours of birth . | NA | {
"id": "C0031190",
"name": "persistent pulmonary hypertension of the newborn",
"pos": [
0,
48
]
} | {
"id": "C0020542",
"name": "pulmonary hypertension",
"pos": [
98,
120
]
} |
it has been observed that gh secretion is in part controlled by hypothalamic gh release-inhibiting factors , two forms of which , somatostatin-14 ( ref . 5 ) and somatostatin-28 ( refs 6-9 ) , have been characterized . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
130,
145
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
162,
177
]
} |
apparently , nifedipine and the novel compounds bind to the same specific dihydropyridine binding sites in or near the calcium channel . | NA | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
13,
23
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
74,
89
]
} |
cloned genes for the different polypeptide chains of one of the human ia antigens , hla-dr , have been used for the co-transformation of mouse l cells . | NA | {
"id": "C0019754",
"name": "human ia",
"pos": [
64,
72
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
84,
90
]
} |
moreover , since the hydrolysis of glutamine is mediated by glutaminase ( ec 3.5.1.2 ) , and calcium does not activate the purified enzyme , an indirect phosphate-dependent effect of calcium on glutaminase is most likely . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
93,
100
]
} | {
"id": "C0006711",
"name": "phosphate",
"pos": [
153,
162
]
} |
norepinephrine , histamine and adenosine or 2-chloroadenosine caused increased swelling of the slices associated with an increased na+ and cl- content . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
31,
40
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
44,
61
]
} |
the results are discussed also with respect to the pharmacological pretreatment with two biological substances which may modulate amino acid ( l-alanine ) and phospholipid metabolism ( cdp-choline ) . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
130,
140
]
} | {
"id": "C0001898",
"name": "l-alanine",
"pos": [
143,
152
]
} |
with increase of glycine , the cerebral levels of glutamine and serine also increased , but that of glutamic acid decreased . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
50,
59
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
100,
113
]
} |
amino acids significantly elevated were aspartate , glutamine , glycine , histidine , ornithine , phenylalanine , phosphoethanolamine and taurine , whereas 1-methyl histidine and 3-methyl histidine were specifically detected in uremic rats . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
0,
11
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
64,
71
]
} |
levels of oxytocin throughout the neurohypophysis did not change in parallel with vasopressin demonstrating relatively selective responses of the neurohypophyseal hormones . | NA | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
10,
18
]
} | {
"id": "C0032017",
"name": "neurohypophyseal hormones",
"pos": [
146,
171
]
} |
this history is needed to identify the course of what may be several important factors that lead to the pathological condition in this disease . | NA | {
"id": "C0030660",
"name": "pathological condition",
"pos": [
104,
126
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
135,
142
]
} |
as the cyst contained no hair follicles nor any sebaceous or sweat glands , it was histologically classified as an epidermoid cyst . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
7,
11
]
} | {
"id": "C0014511",
"name": "epidermoid cyst",
"pos": [
115,
130
]
} |
phenylethanolamine n-methyltransferase , the enzyme responsible for converting noradrenaline to adrenaline , is shown to be inhibited in vivo by p-chlorophenylalanine and in vitro by its metabolite , p-chlorophenylethylamine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
79,
92
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
96,
106
]
} |
supraventricular extrasystoles ( se , 11.55 % ) , atrial fibrillation ( af , 10.44 % ) and ventricular extrasystoles ( ve , 8.91 % ) were the most frequent arrhythmias , followed by sinus bradycardia ( sb , 2.04 % ) , sinus arrhythmia ( sa , 1.35 % ) , atrial flutter ( afl , 1.09 % ) and junctional rhythms ( jr , 0.20 ... | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
156,
167
]
} | {
"id": "C0003813",
"name": "sinus arrhythmia",
"pos": [
218,
234
]
} |
supraventricular extrasystoles ( se , 11.55 % ) , atrial fibrillation ( af , 10.44 % ) and ventricular extrasystoles ( ve , 8.91 % ) were the most frequent arrhythmias , followed by sinus bradycardia ( sb , 2.04 % ) , sinus arrhythmia ( sa , 1.35 % ) , atrial flutter ( afl , 1.09 % ) and junctional rhythms ( jr , 0.20 ... | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
156,
167
]
} | {
"id": "C0004239",
"name": "atrial flutter",
"pos": [
253,
267
]
} |
treatment of rats with gamma-vinyl-gaba , an inhibitor of gaba-transaminase , caused a dose- and time-related increase in brain gaba concentrations concomitant with increases in the concentrations of total gaba and homocarnosine in the csf . | NA | {
"id": "C0048044",
"name": "gamma-vinyl-gaba",
"pos": [
23,
39
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
206,
210
]
} |
dopamine , norepinephrine and epinephrine applied to the isolated superfused frog spinal cord had complex effects on the terminals of primary afferent fibers . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
11,
25
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
30,
41
]
} |
at necropsy 84.8 % were attributed to ischaemic heart disease , 7.1 % to myocarditis , 4.7 % to cardiomyopathy and 3.4 % to valvular disease . | NA | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
73,
84
]
} | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
96,
110
]
} |
the plasma androstenedione , urinary 17-ketosteroids , and 17-hydroxycorticosteroids , as well as the computed axial tomography scan of the adrenal glands were normal . | NA | {
"id": "C0002860",
"name": "androstenedione",
"pos": [
11,
26
]
} | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
37,
52
]
} |
twenty-four postmenopausal women were studied and the estrogens ingested were either conjugated estrogens ( 0.3 or 0.6 mg ) , piperazine estrone sulfate ( 0.6 or 1.2 mg ) , or micronized estradiol ( 1 mg ) . | NA | {
"id": "C0014939",
"name": "estrogens",
"pos": [
54,
63
]
} | {
"id": "C0014938",
"name": "conjugated estrogens",
"pos": [
85,
105
]
} |
some important physiological aspects of the two peptide hormones -- parathyroid hormone and calcitonin -- should be discussed within this article . | NA | {
"id": "C0597192",
"name": "peptide",
"pos": [
48,
55
]
} | {
"id": "C0030520",
"name": "parathyroid hormone",
"pos": [
68,
87
]
} |
the concentration of lactoferrin , a non-heme iron binding glycoprotein , was determined in more than 1500 edta plasma samples by a 2-site solid phase immunoradiometric assay to assess the significance of lactoferrin in plasma and to investigate applications for this assay . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
59,
71
]
} | {
"id": "C0022942",
"name": "lactoferrin",
"pos": [
205,
216
]
} |
all strains were susceptible to erythromycin , clindamycin , chloramphenicol , furazolidone , aminoglycosides ( including gentamicin ) , cefotaxime and nf-thienamycin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
94,
109
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
122,
132
]
} |
[ effect of corticosteroid hormones on the free amino acid content of the spleen in severe mechanical injury ] . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
12,
26
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
27,
35
]
} |
though there were no differences of glycogen content between glucose or galactose feeding in this previously fasted group , combined intravenous glucose and enteric galactose administration produced the greatest effect on hepatic glycogen synthesis . | NA | {
"id": "C0017911",
"name": "glycogen",
"pos": [
36,
44
]
} | {
"id": "C0023902",
"name": "hepatic",
"pos": [
222,
229
]
} |
intrahepatic fructose 1 , 6-diphosphate and phosphoenolpyruvate levels were increased among previously fasted pups fed enteric monosaccharides compared to completely starved control pups , whereas intrahepatic phosphoenolpyruvate and pyruvate levels were elevated after combined intravenous and enteric carbohydrate admi... | NA | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
127,
142
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
303,
315
]
} |
in contrast to the augmented hepatic glycogen and atp levels , there were no alterations of cerebral glycogen or atp after alimentation . | NA | {
"id": "C0023902",
"name": "hepatic glycogen",
"pos": [
29,
45
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
101,
109
]
} |
quantitation of this material from the cells of one of the sibs after isolation on a dowex column yielded 39.8 nmoles of free ( unbound ) sialic acid per mg protein whereas normal fibroblasts had 1 -- 2 nmoles per mg . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
39,
44
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
180,
191
]
} |
activity increased from a mean of 132 pmole/ ( mg protein . h ) x 10 ( -3 ) at 0 days gestation to 326 pmole/mg protein . h ) x 10 ( -3 ) in newborn animals between 1-4 days of age ( r = 0.571 , p less than 0.05 ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
50,
57
]
} | {
"id": "C0032974",
"name": "gestation",
"pos": [
86,
95
]
} |
in contrast to normal qualitative characteristics and to normal or only mildly elevated concentrations of total lipids , neutral lipids , phospholipids , and neutral glycosphingolipids , this study reports a significant elevation of acidic glycosphingolipids , gangliosides ( 387 versus 147 nmole lipid-bound sialic acid... | NA | {
"id": "C0600571",
"name": "acidic glycosphingolipids",
"pos": [
233,
258
]
} | {
"id": "C0017082",
"name": "gangliosides",
"pos": [
261,
273
]
} |
( 1 ) we find that resistance to cycloheximide is due to a transversion mutation resulting in the replacement of a glutamine by glutamic acid in position 37 of l29 . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
115,
124
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
128,
141
]
} |
the results further indicate that the single ribosomal protein of eukaryotic 5s rna-protein complexes interacts with the same region of the 5s rrna molecule as do the multiple protein components in complexes of prokaryotic origin . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
80,
83
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
143,
147
]
} |
results from experiments using both kinds of dna and all three enzymes showed that the 5 ' end of 45s rna mapped to a unique site 125 bases upstream from the hind iii site in the ribosomal dna gene . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
45,
48
]
} | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
179,
192
]
} |
we have analysed nuclear rna from t. thermophila by rna transfer hybridization using cloned rdna fragments . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
17,
28
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
52,
55
]
} |
this result explains why certain sites in mammalian dna are resistant to both mspi and hpaii and shows that this results from an idiosynchracy of mspi rather than a novel form of dna methylation at this site in mammalian cells . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
52,
55
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
218,
219
]
} |
we have developed a method of preparing yeast chromatin that facilitates the analysis of nucleoprotein organization . | NA | {
"id": "C0008546",
"name": "chromatin",
"pos": [
46,
55
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
89,
102
]
} |
the polymerizing and the primer terminus adding reactions of a homogenous e. coli dna polymerase i preparation , as measured by incorporation of [ 3h ] damp into the acid-insoluble fraction , were significantly poorer with uracil-containing template-primers than with thymine templates . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
223,
229
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
268,
275
]
} |
a nucleotide change in the anticodon of an escherichia coli serine transfer rna results in supd-amber suppression . | NA | {
"id": "C0003284",
"name": "anticodon",
"pos": [
27,
36
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
67,
79
]
} |
in comparison with that of psp3 , a delta-globin clone from the gene library of a normal japanese , the anubis delta-globin gene showed one base addition in the second exon at the codon for amino acid 55 , generating a termination codon at the new 59th codon . | NA | {
"id": "C0009221",
"name": "codon",
"pos": [
180,
185
]
} | {
"id": "C0242611",
"name": "termination codon",
"pos": [
219,
236
]
} |
the binding of mg2+ , spermine , and spermidine to wheat germ ribosomes was quantitated following equilibrium dialysis . | NA | {
"id": "C0037874",
"name": "spermine",
"pos": [
22,
30
]
} | {
"id": "C0037871",
"name": "wheat germ",
"pos": [
51,
61
]
} |
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