text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the synthesis and regulation of pregnancy-specific beta 1-glycoprotein ( ps beta g ) in secondary placental cells and human fibroblasts was studied in vitro . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
108,
113
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
124,
135
]
} |
the secondary placental cells , however , produced considerably higher levels of ps beta g than did the human fibroblasts in both the absence and presence of inducers . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
24,
29
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
110,
121
]
} |
the synthesis of ps beta g in the secondary placental cells and human fibroblasts was induced by sodium butyrate and 5-bromo-2'-deoxyuridine ( brdurd ) but was not affected by agents that increase intracellular camp concentrations and retinoic acid . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
54,
59
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
70,
81
]
} |
the synthesis of two other placental markers , human chorionic gonadotropin ( hcg ) and the alpha subunit of hcg ( hcg alpha ) , was also studied in both types of cells . | NA | {
"id": "C0018062",
"name": "human chorionic",
"pos": [
47,
62
]
} | {
"id": "C0017963",
"name": "alpha subunit",
"pos": [
92,
105
]
} |
the presence of ps beta g in secondary placental cells and human fibroblasts suggests that ps beta g may be associated with growth and maintenance of nontransformed cells in vitro . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
49,
54
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
65,
76
]
} |
these data suggest that human renal cell carcinomas have a new isozyme of ace differing in part immunologically from the enzyme of normal kidney . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
63,
70
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
121,
127
]
} |
the acinar , papillary and bronchiolo-alveolar carcinomas were well or moderately differentiated and the solid adenocarcinomas were poorly differentiated tumours secreting mucus in intracytoplasmic vacuoles . | NA | {
"id": "C0007120",
"name": "bronchiolo-alveolar",
"pos": [
27,
46
]
} | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
111,
126
]
} |
apart from normal and inflamed parotid glands , different kinds of tumours were studied with regard to amylase : acinic cell tumours , adenocarcinomas , adenoidcystic carcinomas , salivary duct carcinomas , mucoepidermoid tumours and squamous cell carcinomas . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
135,
150
]
} | {
"id": "C0010606",
"name": "adenoidcystic carcinomas",
"pos": [
153,
177
]
} |
amino acid analysis showed a very low sulfur amino acid content and relatively high content of aspartic and glutamic acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0002527",
"name": "sulfur amino acid",
"pos": [
38,
55
]
} |
thus , the microsomal proteins needed for assembly may be determined by the nature of the precursor protein itself . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
22,
30
]
} | {
"id": "C0033665",
"name": "precursor protein",
"pos": [
90,
107
]
} |
this normal cellular homologue of the amv leukemogenic protein , p110proto-amv , was not present in normal fibroblasts , mav-1 infected fibroblasts , or , interestingly , in some leukemic myeloblasts . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
12,
20
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
136,
147
]
} |
progesterone receptor-monoclonal antibody complexes were labeled with radioactive progesterone , suggesting that antibody does not prevent hormone binding . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
22,
41
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
113,
121
]
} |
covalent as well as noncovalent binding of polycyclic aromatic hydrocarbons to nucleic acids should decrease the local concentration of water as a result of the insertion of the hydrophobic hydrocarbon into the dna and thereby increase the exposure of the dna h bonds to na+ attack . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
79,
92
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
256,
259
]
} |
the immunoaffinity column-purified protein from these cells also bound to dna and was indistinguishable from the purified protein from mc29-transformed fibroblasts . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
152,
163
]
} |
leukocyte preparations convert the hydroperoxy icosatetraenoic acids 5 ( s ) -hpete and 15 ( s ) -hpete to the unstable leukotriene epoxides lta4 and 14,15-lta4 . | NA | {
"id": "C0023545",
"name": "leukotriene",
"pos": [
120,
131
]
} | {
"id": "C0125631",
"name": "lta4",
"pos": [
156,
160
]
} |
data are presented that lead to an alternative model for the organization and molecular dynamics of lipid molecules near the ca2+-stimulated , mg2+-dependent adenosinetriphosphatase ( ca2+-atpase ; atp phosphohydrolase , ec 3.6.1.3 ) of sarcoplasmic reticulum . | NA | {
"id": "C0001477",
"name": "ca2",
"pos": [
125,
128
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
198,
218
]
} |
data are presented that lead to an alternative model for the organization and molecular dynamics of lipid molecules near the ca2+-stimulated , mg2+-dependent adenosinetriphosphatase ( ca2+-atpase ; atp phosphohydrolase , ec 3.6.1.3 ) of sarcoplasmic reticulum . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
125,
128
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
198,
218
]
} |
growth of human diploid fibroblasts in the presence of 5-bromodeoxyuridine , followed by flow cytometric analysis of dna-specific fluorescence with hoechst 33258 dye , allows quantitation of the proportion of cells that have not cycled , as well as those in g1 and g2 of two subsequent cell cycles . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
24,
35
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
209,
214
]
} |
the cell cycle kinetics of human diploid fibroblasts at all population doubling levels reveal two components : cycling cells showing a probabilistic rate of g1/s transition , and a variable proportion of noncycling cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
41,
52
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
215,
220
]
} |
interferon ( 100-5,000 units/ml ) induced an acceleration of myotube formation and creatine kinase ( ck ; ec 2.7.3.2 ) isoenzyme transition from ck-bb to ck-mm . | NA | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
83,
98
]
} | {
"id": "C0010289",
"name": "ck-bb",
"pos": [
145,
150
]
} |
interferon ( 100-5,000 units/ml ) induced an acceleration of myotube formation and creatine kinase ( ck ; ec 2.7.3.2 ) isoenzyme transition from ck-bb to ck-mm . | NA | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
83,
98
]
} | {
"id": "C0010291",
"name": "ck-mm",
"pos": [
154,
159
]
} |
administration of deoxycorticosterone raised the level of active kallikrein in urine without affecting the concentration of prekallikrein . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
65,
75
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
124,
137
]
} |
the total kallikrein level ( active kallikrein together with prekallikrein ) , however , returned to normal because dex elevated the prekallikrein level . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
10,
20
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
133,
146
]
} |
demonstration of a neurotrophic factor for the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
62,
82
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
87,
108
]
} |
they were sacrificed 48 hr after denervation , and the acetylcholinesterase ( acetylcholine acetylhydrolase , ec 3.1.1.7 ) and butyrylcholinesterase ( acylcholine acylhydrolase , ec 3.1.1.8 ) contents of the superior cervical ganglia were compared with those of similarly denervated control ganglia . | NA | {
"id": "C0001044",
"name": "acetylcholine",
"pos": [
55,
68
]
} | {
"id": "C0008429",
"name": "acylcholine",
"pos": [
151,
162
]
} |
these findings demonstrate the presence of an endogenous neurotrophic factor for the maintenance of ganglionic acetylcholinesterase and butyrylcholinesterase . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
111,
131
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
136,
157
]
} |
in partial reactions of protein chain initiation , vanadate concentrations that inhibit protein synthesis have no detectable effect on the formation of eukaryotic initiation factor eif-2-promoted ternary complex with met-trnaf and gtp and on the assembly of 40s ribosomal subunit-met-trnaf complexes . | NA | {
"id": "C1136317",
"name": "eukaryotic initiation factor",
"pos": [
152,
180
]
} | {
"id": "C0013729",
"name": "eif-2",
"pos": [
181,
186
]
} |
although the extracts of vsv-infected cells can also support the synthesis of vsv proteins , rna replication is not dependent on de novo protein synthesis but utilizes the preformed soluble proteins present in the infected cell at the time the extract is prepared . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
65,
74
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
190,
198
]
} |
this high specific activity reagent was then used in an attempt to identify proteases in rat islets of langerhans involved in the conversion of proinsulin to insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
144,
154
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
158,
165
]
} |
the two predominant labeled proteins were mainly soluble rather than membrane bound , and they exhibited patterns of competition with various inhibitors that were similar to the pattern shown by the conversion of proinsulin to insulin in vitro . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
213,
223
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
227,
234
]
} |
it is optimally active at ph 6.5 with 0.2 mm divalent cation and 0.2 m monovalent cation . | NA | {
"id": "C0007448",
"name": "divalent cation",
"pos": [
45,
60
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
82,
88
]
} |
the number of deuterium recoils due to neutron capture by hydrogen would also be decreased . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
14,
23
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
58,
66
]
} |
lecithin : cholesterol acyltransferase-mediated modification of discoidal peripheral lymph high density lipoproteins : possible mechanism of formation of cholesterol-induced high density lipoproteins ( hdlc ) in cholesterol-fed dogs . | NA | {
"id": "C0023822",
"name": "cholesterol",
"pos": [
11,
22
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
212,
223
]
} |
our study has revealed that ( i ) monocytes , or a monocyte substitute such as the phorbol ester tetradecanoylphorbol 13-acetate , are required for transferrin receptor expression after mitogen exposure ; | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
83,
96
]
} | {
"id": "C0039654",
"name": "tetradecanoylphorbol",
"pos": [
97,
117
]
} |
correlation of this protein sequence data with the nucleotide sequence of the tsr gene [ boyd , a. , kendall , k. & simon , m.i . ( 1983 ) nature ( london ) 301 , 623-626 ] suggests that cheb-dependent modification of mcpi is the enzymatic deamidation of glutamine to methyl-accepting glutamic acid . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
255,
264
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
285,
298
]
} |
pretreatment of erythrocyte ghosts with the cytosolic factor resulted in a 5- to 15-fold activation of adenylate cyclase in the presence or absence of naf , 5'-guanylyl imidodiphosphate , or isoproterenol and gtp . | NA | {
"id": "C0018366",
"name": "guanylyl imidodiphosphate",
"pos": [
160,
185
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
209,
212
]
} |
we demonstrate that the level of mrna for this enzyme is under developmental control and suggest a structural model for the protein kinase-mediated regulation of the mammalian liver isozyme . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
47,
53
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
182,
189
]
} |
the amino acid sequences of rat liver lysosomal thiol endopeptidases , cathepsins b and h , are presented and compared with that of the plant thiol protease papain . | NA | {
"id": "C0010661",
"name": "thiol protease",
"pos": [
142,
156
]
} | {
"id": "C0030346",
"name": "papain",
"pos": [
157,
163
]
} |
thioredoxins are small redox proteins , alternating between the s-s ( oxidized ) and sh ( reduced ) states , that function in a number of important biochemical processes , including dna synthesis , dna replication , and enzyme regulation . | NA | {
"id": "C0039938",
"name": "thioredoxins",
"pos": [
0,
12
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
29,
37
]
} |
these antibodies were found to be directed against antigens on the surface of mouse b 16 melanoma cells but not on normal mouse cells such as 3t3 fibroblasts . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
115,
121
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
146,
157
]
} |
although the composition of gags was similar in all cultures , consisting of approximately 60 % chondroitin and 40 % heparin or heparan sulfate , the degree of sulfation of the heparin or heparan sulfate molecules was markedly decreased in cultures grown on collagen . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
28,
32
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
96,
107
]
} |
although the composition of gags was similar in all cultures , consisting of approximately 60 % chondroitin and 40 % heparin or heparan sulfate , the degree of sulfation of the heparin or heparan sulfate molecules was markedly decreased in cultures grown on collagen . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
28,
32
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
177,
184
]
} |
although the composition of gags was similar in all cultures , consisting of approximately 60 % chondroitin and 40 % heparin or heparan sulfate , the degree of sulfation of the heparin or heparan sulfate molecules was markedly decreased in cultures grown on collagen . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
28,
32
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
188,
203
]
} |
several of these hybrid lines showed reactivity with monoclonal antibodies known to be specific for human myeloid cells , whereas interlineage chinese hamster fibroblast-human chronic myeloid leukemia hybrids failed to react with these antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
53,
74
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
236,
246
]
} |
the patterns of hybridization were highly polymorphic but one endonuclease , bamhi , defined sequences unique to all hla-dw/dr specificities 1-8 except hla-dw/dr 2 and 6 ; | NA | {
"id": "C0019754",
"name": "hla-dw",
"pos": [
117,
123
]
} | {
"id": "C0019764",
"name": "hla",
"pos": [
152,
155
]
} |
both activities were eliminated by a highly specific neutralizing antibody against mouse interferon-gamma , but not by antibody against interferon-alpha and -beta . | NA | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
53,
74
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
119,
127
]
} |
it was concluded from these data that the priming activity in hybridoma culture supernates was attributable to interferon-gamma and that this mediator is one form of the lymphokine macrophage-activating factor . | NA | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
170,
180
]
} | {
"id": "C0079786",
"name": "macrophage-activating factor",
"pos": [
181,
209
]
} |
we have identified many clones that express p. falciparum antigens by immunological screening in situ with antibodies from immune human sera that inhibit p. falciparum growth in vitro . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
107,
117
]
} | {
"id": "C0020960",
"name": "immune",
"pos": [
123,
129
]
} |
lysis of nucleated cells by complement was studied to determine whether the lytic process by c5b-9 conforms to a one-hit mechanism as in the case of erythrocytes . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
28,
38
]
} | {
"id": "C0009545",
"name": "c5b-9",
"pos": [
93,
98
]
} |
the pore is anion selective , differing from porins of other gram-negative bacteria studied so far but resembling the voltage-dependent anion-selective channel of the outer membrane of mitochondria . | NA | {
"id": "C0071728",
"name": "gram-negative bacteria",
"pos": [
61,
83
]
} | {
"id": "C1506024",
"name": "voltage-dependent anion",
"pos": [
118,
141
]
} |
the combined effect of copper and insulin significantly decreased peak blood glucose at 30 min and increased the incorporation of [ 14c ] glucose into lipid in the epididymal fat pad when compared to either copper or insulin alone . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
71,
84
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
138,
145
]
} |
catecholamine-induced thermogenesis is significantly diminished in bio 14.6 cardiomyopathic hamsters as demonstrated by a reduced increase in oxygen consumption of these hamsters in response to administered isoproterenol . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
0,
13
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
207,
220
]
} |
responsiveness to ct was examined by giving porcine or salmon ct iv and measuring serum ca 1-3 hr later . | NA | {
"id": "C0006668",
"name": "ct",
"pos": [
18,
20
]
} | {
"id": "C0073994",
"name": "salmon",
"pos": [
55,
61
]
} |
determination of plasma lipoproteins by a sensitive agarose gel electrophoretic technique demonstrated : ( a ) in the patients with two prebeta bands an intensification of the fast prebeta lipoprotein fraction after growth hormone administration ; | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
24,
36
]
} | {
"id": "C0023825",
"name": "prebeta",
"pos": [
181,
188
]
} |
in progressive multifocal leukoencephalopathy there is an opportunistic and lytic infection of oligodendrocytes of the central nervous system leading to subacute demyelinating disease . | NA | {
"id": "C0023524",
"name": "progressive multifocal leukoencephalopathy",
"pos": [
3,
45
]
} | {
"id": "C0011303",
"name": "demyelinating disease",
"pos": [
162,
183
]
} |
because fasting and ketogenic diets decrease seizure susceptibility in epileptics , their anticonvulsant effects were studied using sound-induced seizures in the magnesium-deficient rat . | NA | {
"id": "C0014544",
"name": "seizure",
"pos": [
45,
52
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
146,
154
]
} |
plasma taken by jugular catheter showed that non-coping rats , compared with coping rats , had significantly higher peak norepinephrine ( ne ) and epinephrine ( e ) concentrations and significantly longer elevation of these catecholamines after footshock . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
121,
135
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
147,
158
]
} |
different groups of mice were assessed for sleep time , waking blood alcohol concentration ( bac ) , and waking brain ethanol concentration ( brec ) at 03.00 , 09.00 , 15.00 , or 21.00 hr . | NA | {
"id": "C0684262",
"name": "blood alcohol",
"pos": [
63,
76
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
118,
125
]
} |
ss animals given the 4.1 g/kg dose showed circadian variations for waking bac and waking brec , but not for sleep time . | NA | {
"id": "C0684262",
"name": "bac",
"pos": [
74,
77
]
} | {
"id": "C0001962",
"name": "brec",
"pos": [
89,
93
]
} |
ss mice given the 5.0 g/kg dose slept longer than those given the 4.1 g/kg dose and did not show circadian variations for sleep time , waking bac , or waking brec . | NA | {
"id": "C0684262",
"name": "bac",
"pos": [
142,
145
]
} | {
"id": "C0001962",
"name": "brec",
"pos": [
158,
162
]
} |
similar experiments on tumour-bearing mice showed a decrease of t1 in the tumour , the spleen , the kidneys , and the liver . | NA | {
"id": "C0027659",
"name": "experiments",
"pos": [
8,
19
]
} | {
"id": "C0027651",
"name": "tumour",
"pos": [
74,
80
]
} |
these results suggest that saralasin was acting as an angiotensin ii agonist in the kidney , but as an antagonist elsewhere . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
27,
36
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
54,
68
]
} |
deductions from previous experiments in the literature of the renal function of angiotensin ii , based on its supposed inhibition by saralasin , may not be justified . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
80,
94
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
133,
142
]
} |
the effects of adrenaline and noradrenaline on membrane potential and glucose-induced electrical activity were studied in micro-dissected mouse islets of langerhans . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
15,
25
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
30,
43
]
} |
hypoxic cells irradiated in the presence of the nitroimidazoles ( e.g. , misonidazole ) are sensitized at ultrahigh dose rates in a dose-modifying manner , similar to that observed at conventional dose rates . | NA | {
"id": "C0028179",
"name": "nitroimidazoles",
"pos": [
48,
63
]
} | {
"id": "C0026218",
"name": "misonidazole",
"pos": [
73,
85
]
} |
these effects were studied by in vivo determination of single-strand dna breaks by alkaline sucrose gradient sedimentation using the daba fluorescent technique to detect the dna . | NA | {
"id": "C0012935",
"name": "single-strand dna",
"pos": [
55,
72
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
174,
177
]
} |
the specific activity of nonexchangeable tritium in these amino acids relative to the specific activity of tritium in the tissue water of mice ranged from 0.04 for phenylalanine and threonine to 1.0 for glycine and alanine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
58,
69
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
203,
210
]
} |
the specific activity of nonexchangeable tritium in these amino acids relative to the specific activity of tritium in the tissue water of mice ranged from 0.04 for phenylalanine and threonine to 1.0 for glycine and alanine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
58,
69
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
215,
222
]
} |
v-79 chinese hamster fibroblasts in monolayer culture were exposed to ultraviolet radiation at 313 , 334 , 365 , 380 , and 405 nm in the presence of either misonidazole or para-nitroacetophenone , drugs which act as both photosensitizers and radiosensitizers of cell killing . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
21,
32
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
262,
266
]
} |
differences in replicon behavior between x-irradiation-sensitive l5178y mouse lymphoma cells and a-t fibroblasts using dna fiber autoradiography . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
87,
92
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
101,
112
]
} |
replicon behavior in radiosensitive ataxia telangiectasia ( a-t ) fibroblasts and mouse lymphoma l5178y ( ls ) cells was studied by dna fiber autoradiography . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
66,
77
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
111,
116
]
} |
gamma-irradiated or nonirradiated fibroblasts were infected with either nonirradiated or irradiated ad 2 , and 48 hr after infection cells were examined for the presence of viral structural antigens ( vag ) using immunofluorescent staining . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
34,
45
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
133,
138
]
} |
rejoining followed biphasic kinetics , with 70 % of the breaks disappearing with a half-life of about 3 min . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
28,
36
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
83,
92
]
} |
ct is sensitive and specific for the diagnosis of hemoperitoneum and can estimate the extent and probable source of bleeding . | NA | {
"id": "C0019065",
"name": "hemoperitoneum",
"pos": [
50,
64
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
116,
124
]
} |
an in vitro examination of the effects of radiopaque contrast media anions , cations , additives , and ionic strength on ionic calcium level using ion-specific electrodes was made . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
68,
74
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
147,
150
]
} |
an in vitro examination of the effects of radiopaque contrast media anions , cations , additives , and ionic strength on ionic calcium level using ion-specific electrodes was made . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
77,
84
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
147,
150
]
} |
at the same iodine concentration the anions diatrizoate , iothalamate , metrizoate , and ioxaglate reduced ionic calcium by essentially the same amount . | NA | {
"id": "C0021966",
"name": "iodine",
"pos": [
12,
18
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
37,
43
]
} |
at the same iodine concentration the anions diatrizoate , iothalamate , metrizoate , and ioxaglate reduced ionic calcium by essentially the same amount . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
37,
43
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
107,
112
]
} |
these results , together with our data concerning mycocardial infarction ( 27-29,31 ) , make it necessary to reconsider the role of cardiomyocyte hyperplasia in different experimental and pathological conditions , paying special attention to the proliferative behavior of the atrial muscle cells . | NA | {
"id": "C0020507",
"name": "hyperplasia",
"pos": [
146,
157
]
} | {
"id": "C0030660",
"name": "pathological conditions",
"pos": [
188,
211
]
} |
the intramyocardial concentration of utp and uracil nucleotides rose during the early phase of hypertrophy , while the atp and adenine nucleotide pools were depleted . | NA | {
"id": "C0042010",
"name": "utp",
"pos": [
37,
40
]
} | {
"id": "C0041921",
"name": "uracil nucleotides",
"pos": [
45,
63
]
} |
these factors are kallikrein for kinins and converting enzyme for the renin-angiotensin system , 9-ketoreductase and phospholipase for kinin and prostaglandin systems , and hageman factors for coagulation , fibrinolysis , and kininogenesis systems . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
18,
28
]
} | {
"id": "C0005789",
"name": "factors",
"pos": [
181,
188
]
} |
sodium nitroprusside ( nitroprusside ) and ne elevated the cgmp and camp , respectively , in both hioxsa and hypoxia . | NA | {
"id": "C0037533",
"name": "sodium",
"pos": [
0,
6
]
} | {
"id": "C0028193",
"name": "nitroprusside",
"pos": [
23,
36
]
} |
various buffers ( 0.2 m acetate , ph 4.2 ; 0.01 m phosphate with 0.15 m sodium chloride , ph 7.2 ; 0.15 m borate , ph 8.2 and 0.025 m carbonate , ph 9.6 ) were used as coating buffers with brucella abortus alkali treated lipopolysaccharide on two types of plastic matrices . | NA | {
"id": "C0007026",
"name": "carbonate",
"pos": [
134,
143
]
} | {
"id": "C0002055",
"name": "alkali",
"pos": [
206,
212
]
} |
repeat fiberoptic bronchoscopy ( fb ) is indicated in patients with recurrent , unexplained hemoptysis to localize and/or diagnose the source of bleeding . | NA | {
"id": "C0019079",
"name": "hemoptysis",
"pos": [
92,
102
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
145,
153
]
} |
by evaluating the pathophysiology of the underlying disease , it is possible to choose between merely replacing the removed volume by non-protein fluids or rather to introduce plasma protein components into the patient 's circulation by substituting with purified or enriched proteins such as albumin , clotting factors ... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
276,
284
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
293,
300
]
} |
from a series of 400 cases of lumbar spine phlebography by selective catheterisation , 4 serious thrombo-embolic episodes were observed , including 2 cases of severe pulmonary embolism which responded favourably to medical treatment . | NA | {
"id": "C0013922",
"name": "embolic",
"pos": [
105,
112
]
} | {
"id": "C0034065",
"name": "pulmonary embolism",
"pos": [
166,
184
]
} |
for the experimental diet , an additive containing 75 parts/10 ( 6 ) fluoride as ( naf ) and 50 parts/10 ( 6 ) magnesium ( as mgo ) was mixed into the above composition . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
69,
77
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
83,
86
]
} |
by using isolated human complement factors c3 , b and d , agarose beads were coated with c3b . | NA | {
"id": "C0009506",
"name": "complement",
"pos": [
24,
34
]
} | {
"id": "C0009511",
"name": "c3b",
"pos": [
89,
92
]
} |
in a study to determine the epidemiological situation of n. gonorrhoeae ( ng ) in switzerland , 149 strains isolated from different regions over the period september 1981 to february 1982 were analyzed for sensitivity to various antibiotics ( minimum inhibitory concentration [ mic ] for penicillin g , ampicillin , cefu... | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
288,
300
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
303,
313
]
} |
the 2 cases reported here indicate that on ultrasound examination uninfected simple and echinococcal cysts can sometimes show a pseudosolid internal consistency like that of a neoplasm , probably owing to floating crystals or particles . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
101,
106
]
} | {
"id": "C0027651",
"name": "neoplasm",
"pos": [
176,
184
]
} |
human fibroblasts expressed all three antigens , and no cross-reactivity with chinese hamster or mouse cells was found . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
6,
17
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
103,
108
]
} |
it is important to differentiate between these two pathologic conditions because the operation required for the treatment of the two diseases is of a different order of magnitude . | NA | {
"id": "C0030660",
"name": "pathologic",
"pos": [
51,
61
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
133,
141
]
} |
in order to assess the role of endogenous prostaglandins in the pathogenesis of stress ulceration , we measured the amounts of prostaglandin e ( pge ) generated by gastric mucosal samples from rats exposed to cold restraint stress . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
42,
56
]
} | {
"id": "C0033559",
"name": "prostaglandin",
"pos": [
127,
140
]
} |
these findings may have a bearing on the protease-antiprotease theory of the development of pulmonary emphysema , lmi possibly playing a part in the protection of peripheral lung tissue against proteolytic destruction by enzymes liberated from granulocytes or migrating alveolar macrophages . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
41,
49
]
} | {
"id": "C0030940",
"name": "proteolytic",
"pos": [
194,
205
]
} |
a marked reduction of alpha 2-antiplasmin was seen after both 0.5 and 1 mg of streptokinase treatment but were not seen in rabbits infused with plasminogen activator . | NA | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
78,
91
]
} | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
144,
165
]
} |
from these data it is concluded , that infections of soft tissue have markedly decreased from 7 to 2 % while secondary wound healing without purulent infection has fallen from 21 % to 5 % . | NA | {
"id": "C0149778",
"name": "infections",
"pos": [
39,
49
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
150,
159
]
} |
analysis of the restriction elements for the recognition of viral antigens , demonstrated that most clones recognized antigens associated with but not identical to serologically defined hla-dr specificities . | NA | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
60,
74
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
118,
126
]
} |
the percentage of esterified cholesterol was not significantly different from that of the controls , and no significant differences in the cholesterol ester fatty acid composition were observed . | NA | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
18,
40
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
139,
150
]
} |
in addition , total hepatic thiobarbituric acid-reactive substances ( assayed as malondialdehyde ) were significantly increased in the pbb-dosed animals . | NA | {
"id": "C0162781",
"name": "thiobarbituric acid-reactive substances",
"pos": [
28,
67
]
} | {
"id": "C0024643",
"name": "malondialdehyde",
"pos": [
81,
96
]
} |
generally , prolonged heavy-metal ingestion at these levels resulted in impaired energy metabolism ( e.g. , decreased atp , pcr ; increased pj , adp concentrations ) and altered essential mineral composition ( e.g. , calcium , magnesium , zinc , and to a lesser extent , sodium and potassium ; copper levels were unaffec... | NA | {
"id": "C0347988",
"name": "heavy-metal",
"pos": [
22,
33
]
} | {
"id": "C0043481",
"name": "zinc",
"pos": [
239,
243
]
} |
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