text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
it is concluded that there is a significant interaction between the aldehydes and guanethidine which may have implications for someone undergoing treatment with guanethidine for hypertension while being exposed to acetaldehyde and related compounds from ethanol and tobacco smoke . | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
68,
77
]
} | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
214,
226
]
} |
disposition , elimination and metabolism of o-ethyl o-4-nitrophenyl phenylphosphonothioate after subchronic dermal application in male cats . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
14,
25
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
30,
40
]
} |
the metabolism , distribution , and excretion of the insecticide o-ethyl o-4-nitrophenyl phenylphosphonothioate ( epn ) were studied in the male cat . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
4,
14
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
36,
45
]
} |
the enzymic activities , reduced cytochrome p-450 : co and ethylisocyanide binding difference spectra and electrophoretic mobilities of the induced microsomal proteins were comparable to those observed after administration of the classical inducer of microsomal aryl hydrocarbon hydroxylase , 3-methylcholanthrene . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
33,
49
]
} | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
262,
290
]
} |
the main proteinase inhibitor from rhodactis rhodostoma is composed of 48 amino acids and inhibits trypsin , kallikrein and chymotrypsin , whereas the semipure inhibitor from rhadianthus koseirensis has very low affinity for serine proteases and does not inhibit chymotrypsin . | NA | {
"id": "C0041236",
"name": "trypsin",
"pos": [
99,
106
]
} | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
225,
241
]
} |
the main proteinase inhibitor from rhodactis rhodostoma is composed of 48 amino acids and inhibits trypsin , kallikrein and chymotrypsin , whereas the semipure inhibitor from rhadianthus koseirensis has very low affinity for serine proteases and does not inhibit chymotrypsin . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
225,
241
]
} | {
"id": "C0008742",
"name": "chymotrypsin",
"pos": [
263,
275
]
} |
the lai test and the amoebic gel diffusion ( agd ) test were performed on 20 patients admitted to hospital with amoebic liver abscess ( ala ) and 24 control subjects with no demonstrable clinical amoebiasis . | NA | {
"id": "C0023886",
"name": "amoebic liver abscess",
"pos": [
112,
133
]
} | {
"id": "C0002438",
"name": "amoebiasis",
"pos": [
196,
206
]
} |
the second bolivian zymodeme , bolivian z2 , was related to brazilian z2 but differed from all the brazilian zymodemes in the occurrence of typical heterozygous isozyme patterns in five out of 12 enzyme loci . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
161,
168
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
196,
202
]
} |
[ membrane potential , permeability coefficients and the ratio of the influx/efflux rates for alkaline cations across the muscle fiber membrane of the frog in a bi-ionic system ] . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
103,
110
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
164,
169
]
} |
the influx/efflux rate constants ratio for all of the cations tested did not obey the ussing criterion for independent passive movement of ion across membrane . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
54,
61
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
139,
142
]
} |
it is suggested that some relationship may exist between sag cell ( glycoprotein hormone precursor cells ? ) tumors -- or at least part of them -- and glycoprotein hormone cell lines . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
61,
65
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
89,
104
]
} |
in the periphery of each cartilagelike island was a perichondriumlike structure exhibiting transitional features from fibroblastic cells to chondrocytic cells . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
118,
130
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
153,
158
]
} |
this response as reflected in the expressed prostatic secretion is specific for the infecting organism and immunoglobulin a is the major antibody class involved . | NA | {
"id": "C0020835",
"name": "immunoglobulin a",
"pos": [
107,
123
]
} | {
"id": "C0021017",
"name": "antibody class",
"pos": [
137,
151
]
} |
prolactin cell hyperplasia occurred in nearly equal percentages ( 17-23 % ) in normal pituitaries and in areas adjacent to gh- , prolactin- or acth-secreting adenomas or adjacent to inactive adenomas . | NA | {
"id": "C1306214",
"name": "acth-secreting adenomas",
"pos": [
143,
166
]
} | {
"id": "C0001430",
"name": "adenomas",
"pos": [
191,
199
]
} |
acth cell hyperplasia was found in 13 % of the normal pituitaries , in 14 % of the cases with prolactin secreting adenomas , in 58 % of the cases with acth producing adenomas and in 40 % of the pituitaries with gh secreting adenomas . | NA | {
"id": "C0033375",
"name": "prolactin secreting adenomas",
"pos": [
94,
122
]
} | {
"id": "C0001430",
"name": "adenomas",
"pos": [
224,
232
]
} |
macrophages and also to some extent fibroblasts have the ability to endocytose collagen and cell debris including split off portions of smooth muscle cell cytoplasm . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
36,
47
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
150,
154
]
} |
the results of this analysis indicate that sv101 contains nondefective viral dna as well as defective viral dna of the following sizes : 5.0 , 4.3 , 3.7 , 3.4 , and 1.5 kb . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
71,
80
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
108,
111
]
} |
despite a considerable amount of viral dna rearrangement which accompanies subcloning , anchorage-independent subclones of sv101 retain defective viral dna , especially the 4.3- and 3.7-kb monomers . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
33,
42
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
152,
155
]
} |
h protein , a minor protein of tmv virions , contains sequences of the viral coat protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
2,
9
]
} | {
"id": "C0042736",
"name": "viral",
"pos": [
71,
76
]
} |
virions of two strains of tobacco mosaic virus ( u1 and cc ) have associated with them a small amount of a minor protein called h protein ( a. asselin and m. zaitlin , 1978 , virology 91 , 173-181 ) , now known to be related to the viral coat protein ( c.w . collmer , v.m . vogt , and m. zaitlin , 1983 , virology 126 ,... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
113,
120
]
} | {
"id": "C0042736",
"name": "viral",
"pos": [
232,
237
]
} |
viral dna from papillomas , which consists mostly of unit-sized form i and form ii dna and from carcinomas in which large oligomeric forms predominate was separated into fractions containing viral plasmids of different size and conformation . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
0,
9
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
83,
86
]
} |
these antibodies together with monoclonal antibodies to the different antigenic regions of the h3 ha were used in immunoprecipitation and elisa binding studies to show that antigenic changes accompanied the conformational change in the ha . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
6,
16
]
} | {
"id": "C0003250",
"name": "antibodies",
"pos": [
42,
52
]
} |
increase in content of methemoglobin as well as the ratio between amount of this hemoglobin and fetal hemoglobin were observed in erythrocytes of children with hypothyrosis . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
26,
36
]
} | {
"id": "C0015936",
"name": "fetal hemoglobin",
"pos": [
96,
112
]
} |
excretion of adrenaline was increased in patients with chronic recurrent pancreatitis , excretion of noradrenaline tended to decrease although the content of this amine exceeded 1.5-2-fold its normal concentration in individual patients ; | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
13,
23
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
101,
114
]
} |
quantitative estimation of native and treated with 4 % formaldehyde albumin , pepsin , lysozyme , histone , gelatin and other proteins was carried out using four procedures -- biurete , lowry-folin , ninhydrin and coomassy r-250 . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
68,
75
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
126,
134
]
} |
an approach of dehydrogenase fractions to the micells of nonionic detergents during enzyme gel electrophoresis led to an increase in colour intensity of individual isoenzymes and to redistribution of the isoenzyme spectrum as a result of catalytic effect of the detergents . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
84,
90
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
204,
213
]
} |
content of tryptophane , tyrosine , serotonin , noradrenaline , adrenaline and dopamine was studied in blood serum and various brain regions of rats with genetically determined spontaneous form of hypertension . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
48,
61
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
64,
74
]
} |
changes in serum lipoprotein pattern and in total content of low density lipoproteins ( ldl ) and very low density lipoproteins ( vldl ) were studied in blood and liver tissues of rats during physical exercise and restoration . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
17,
28
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
98,
127
]
} |
[ anti-tumor activity of the polysaccharide mannan , and its effect on the dynamics of cyclic nucleotides in tissue ] . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
29,
43
]
} | {
"id": "C0024727",
"name": "mannan",
"pos": [
44,
50
]
} |
mice with transplantable harding-passey melanoma were treated with polysaccharide mannan ( 50 mg/kg ) , cyclophosphamide ( 20 and 100 mg/kg ) and their combinations . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
67,
81
]
} | {
"id": "C0024727",
"name": "mannan",
"pos": [
82,
88
]
} |
study of the spectrum of acid proteases of dog gastric juice secreted in response to different stimuli in health and atophan gastric ulcer has shown that gastric juice may contain up to 17 proteases as evaluated from relative electrophoretic mobility of protease fractions . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
30,
39
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
254,
262
]
} |
these studies demonstrate that the intravenous immunoglobulin preparation srk-ig has retained functional activity and may have potential value for prophylaxis or therapy of certain bacteria infections . | NA | {
"id": "C0085297",
"name": "intravenous",
"pos": [
35,
46
]
} | {
"id": "C0021027",
"name": "immunoglobulin",
"pos": [
47,
61
]
} |
[ correlations between plasma levels of kininogen and prekallikrein , plasma renin and urinary excretion of adrenaline and noradrenaline in patients with arterial hypertension ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
108,
118
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
123,
136
]
} |
18 pregnancies ( 2.6 % ) ended with a miscarriage or missed abortion up to the 28th week of gestation following amniocentesis . | NA | {
"id": "C0000786",
"name": "miscarriage",
"pos": [
38,
49
]
} | {
"id": "C0000814",
"name": "missed abortion",
"pos": [
53,
68
]
} |
this figure must be compared with 56 cases ( 7.5 % of 741 women originally referred for amniocentesis ) of miscarriage or missed abortion before amniocentesis could be carried out . | NA | {
"id": "C0000786",
"name": "miscarriage",
"pos": [
107,
118
]
} | {
"id": "C0000814",
"name": "missed abortion",
"pos": [
122,
137
]
} |
among the peripheral tumours alveolar cell carcinoma and adenocell carcinoma are the longest delayed , followed by small ( oat ) cell carcinoma , polymorph cell carcinoma and squamous cell carcinoma . | NA | {
"id": "C0262584",
"name": "oat",
"pos": [
123,
126
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
189,
198
]
} |
the concentration in free fatty acids decreased in which the fatty acid pattern is unchanged essentially . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
21,
37
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
61,
71
]
} |
the relative amounts of common antigens present in each strain were estimated primarily by calculating the percent of fluorescence reduction recorded for organisms stained with their homologous conjugates , nonadsorbed and adsorbed with the homologous and heterologous antigens ( strains ) . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
31,
39
]
} | {
"id": "C0003333",
"name": "heterologous antigens",
"pos": [
256,
277
]
} |
the nature of chondropathia patellae as an insertion tendopathy is discussed , taking the lack of concomitance of chondropathy and chondromalacia into consideration as well as the findings in the group of patients examined . | NA | {
"id": "C0008475",
"name": "chondropathia patellae",
"pos": [
14,
36
]
} | {
"id": "C0007302",
"name": "chondropathy",
"pos": [
114,
126
]
} |
the causes of death were related to the liver disease in 136 cases ( 28.6 % ) ( bleeding from esophagical varices in 60 cases = 44 % of cirrhosis , and coma hepatic in 48 cases = 35 % of cirrhoses ) . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
40,
53
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
136,
145
]
} |
the prognosis of epidural haemorrhages is more favourable for such children than for older children and adults . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
67,
75
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
85,
99
]
} |
studies have been made on the ionic and osmotic indices of the blood , as well as on the content of water and electrolytes in different tissues of rats from 2 age groups ( adult animals over 90 days and 18-24 days old ones ) in the course of water deprivation within 7 days . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
30,
35
]
} | {
"id": "C0013832",
"name": "electrolytes",
"pos": [
110,
122
]
} |
the athena scale , neurovegetative indices as well as those of adrenaline , noradrenaline , dopamine , and dopa excretion were used for delirium gravity estimation . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
63,
73
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
76,
89
]
} |
all subjects were then stratified according to blood glucose values 2 h after an oral glucose load ( after load ) : only those with blood glucose after load greater than 200 mg/dl displayed a significant decrease in btbv ( 9.7 +/- 3.8 beats/min ) compared to those found normal at the glucose tolerance test ( p less tha... | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
53,
60
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
132,
145
]
} |
because of the widespread long-term clinical use of luteinizing hormone-releasing hormone ( lrh ) agonists , the possibility of antibody development to one of these , ( d-ser- ( butt ) 6 ) lrh ( 1-9 ) nonapeptide-ethylamide ( buserelin ) , has been studied by examining sera from experimental animals and humans receivin... | NA | {
"id": "C0023610",
"name": "lrh",
"pos": [
92,
95
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
384,
393
]
} |
serum from one of the animals immunized against unconjugated buserelin and from 9 of the animals immunized against conjugated buserelin had the capacity to bind 125i-labelled lrh . | NA | {
"id": "C0006456",
"name": "buserelin",
"pos": [
61,
70
]
} | {
"id": "C0023610",
"name": "lrh",
"pos": [
175,
178
]
} |
we conclude that the possibility of circulating antibodies being produced to buserelin or their interfering with the action of endogenous lrh is extremely low . | NA | {
"id": "C0006456",
"name": "buserelin",
"pos": [
77,
86
]
} | {
"id": "C0023610",
"name": "lrh",
"pos": [
138,
141
]
} |
plasma concentrations and anterior pituitary content of growth hormone ( rgh ) , thyroid stimulating hormone ( rtsh ) , and rat prolactin ( rprl ) as well as the plasma concentrations of triiodothyronine ( t3 ) , thyroxine ( t4 ) and somatomedin a ( sm-a ) have been determined in intact , castrated or hysterectomized a... | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
26,
44
]
} | {
"id": "C0040160",
"name": "thyroid stimulating hormone",
"pos": [
81,
108
]
} |
our results provide further evidence that isolated deficiency of 1 alpha,25 ( oh ) 2d may cause osteomalacia or rickets . | NA | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
96,
108
]
} | {
"id": "C0035579",
"name": "rickets",
"pos": [
112,
119
]
} |
the effects of the hypoglycaemia sulphonylurea glibenclamide ( hb419 ) and the non-metabolizable leucine analogue beta-2-aminobicyclo ( 2.2.1 ) heptane-2-carboxylic acid ( bch ) on insulin release and endogenous substrate metabolism were studied in isolated rat islets . | NA | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
33,
46
]
} | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
47,
60
]
} |
treatment with natural prostaglandins and especially prostaglandin analogues administered by non-invasive routes seems to be an attractive alternative to methods in current use . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
23,
37
]
} | {
"id": "C0033568",
"name": "prostaglandin analogues",
"pos": [
53,
76
]
} |
in the follicular phase of the menstrual cycle pgs increased the labelling with [ 3h ] glucosamine but reduced the labelling with [ 3h ] hydroxyproline , [ 3h ] proline and [ 3h ] glycine . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
137,
151
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
161,
168
]
} |
the availability of norethindrone ( net ) in serum was studied in 8 women after daily administration of a combination oral contraceptive pill ( minovlarr ) containing 1 mg norethindrone acetate ( neta ) and 50 micrograms ethinyl estradiol ( ee2 ) from day 5 to day 25 of the menstrual cycle . | NA | {
"id": "C0028356",
"name": "norethindrone",
"pos": [
20,
33
]
} | {
"id": "C0068980",
"name": "norethindrone acetate",
"pos": [
172,
193
]
} |
acuity determinations with preferential looking proved useful for evaluation of the effects of amblyopia treatment in young children ( 0-3 years ) with esotropia and for monitoring visual development in children operated early for congenital cataract . | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
118,
132
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
203,
211
]
} |
we have also used these methods successfully for diagnostic acuity determinations in very young children or in older but mentally retarded children with suspected visual impairment . | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
90,
104
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
139,
147
]
} |
over the years more and more fractures were caused by slight trauma whereas the more severe trauma - even if increasing somewhat in risk - contributed a smaller fraction of the injuries . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
29,
38
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
92,
98
]
} |
significant improvements in eia after the training periods were found in all training groups , but basal asthma improved most in group 3 , probably due to the basal treatment with dscg . | NA | {
"id": "C0004099",
"name": "eia",
"pos": [
28,
31
]
} | {
"id": "C0004096",
"name": "asthma",
"pos": [
105,
111
]
} |
these findings suggest that immunological mechanisms , possibly involving antibody to hepatocyte membrane components and immune complexes , may be involved in the pathogenesis of progressive liver disease in biliary atresia . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
74,
82
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
121,
137
]
} |
the mean intraindividual plasma/urine correlation was r = 0.70 ( p less than 0.001 ) for adrenaline and r = 0.40 ( p less than 0.05 ) for noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
89,
99
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
138,
151
]
} |
cooling was induced by ingestion of ice while the subjects were immersed in water of a temperature prone to elicit only minor cutaneous thermal reflexes . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
36,
39
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
76,
81
]
} |
a series of 113 patients with cervical lymph node metastases from an unknown primary tumour is reported . | NA | {
"id": "C0027627",
"name": "metastases",
"pos": [
50,
60
]
} | {
"id": "C0027667",
"name": "unknown",
"pos": [
69,
76
]
} |
among adp-ribosylated proteins , the 48k protein was the major substrate for the adp-ribosylation , and the content of this protein was estimated to be about 15 pmol/mg membrane protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
22,
29
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
169,
185
]
} |
the lack of cleavage at lysine leading to the release of kallidin instead of bradykinin is due to the inability of porcine pancreatic kallikrein to accommodate an arg-pro leaving group . | NA | {
"id": "C0022474",
"name": "kallidin",
"pos": [
57,
65
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
77,
87
]
} |
kallidin and bradykinin are separated from each other and ballast substances by gradient elution technique ( phosphate buffer , acetonitrile ) and column switching . | NA | {
"id": "C0022474",
"name": "kallidin",
"pos": [
0,
8
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
13,
23
]
} |
bradykinin showing up later in the reaction mixture must be due to impurities of kininogen which convert kallidin to bradykinin . | NA | {
"id": "C0022474",
"name": "kallidin",
"pos": [
105,
113
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
117,
127
]
} |
comparative influence of the ca-ionophore a 23187 , bradykinin , kallidin and eledoisin on the rabbit pulmonary vasculature with special reference to arachidonate metabolism . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
52,
62
]
} | {
"id": "C0022474",
"name": "kallidin",
"pos": [
65,
73
]
} |
in a model of isolated rabbit lungs , perfused with isoionic and isooncotic fluid in a recirculating system , the ca-ionophore a 23187 , bradykinin , ( kallidin ) , and eledoisin all evoke a reversible and reproducible increase in pulmonary vascular resistance , partly with biphasic characteristics . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
137,
147
]
} | {
"id": "C0022474",
"name": "kallidin",
"pos": [
152,
160
]
} |
inhibition of thromboxane-synthetase ( imidazole ) , cyclooxygenase ( indomethacin ) phospholipase activity ( mepacrine ) , and interference with the ca-calmodulin-complex ( trifluoperazine ) each suppresses the increase in resistance due to a 23187 or eledoisin completely and the increase due to bradykinin or kallidin... | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
298,
308
]
} | {
"id": "C0022474",
"name": "kallidin",
"pos": [
312,
320
]
} |
( 1 ) activation of prekallikrein by factor xii , ( 2 ) activation of factor xii by plasma kallikrein and ( 3 ) activation of prekallikrein by factor xiia . | NA | {
"id": "C0015525",
"name": "factor xii",
"pos": [
37,
47
]
} | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
143,
154
]
} |
the concave upward curve due to an autocatalytic activation was not observed even after the addition of factor xiia to factor xii preparation . | NA | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
104,
115
]
} | {
"id": "C0015525",
"name": "factor xii",
"pos": [
119,
129
]
} |
( 3 ) the rates of activation of prekallikrein by factor xii and by factor xiia were approximately the same at higher concentration of prekallikrein . | NA | {
"id": "C0015525",
"name": "factor xii",
"pos": [
50,
60
]
} | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
68,
79
]
} |
however , at lower concentration of prekallikrein the rate of activation of prekallikrein by factor xii was shown to be a sigmoidal curve and slower than that by factor xiia . | NA | {
"id": "C0015525",
"name": "factor xii",
"pos": [
93,
103
]
} | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
162,
173
]
} |
functional kallikrein inhibition and prekallikrein levels have been studied during septic shock and septicemia in 13 patients using chromogenic peptide substrate assays . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
11,
21
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
37,
50
]
} |
during treatment a gradual increase in prekallikrein was observed in the survivors and functional kallikrein inhibition values remained in the normal range during the whole course . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
39,
52
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
98,
108
]
} |
only one patient ( with heart disease ) of the 27 patients in the second part of the study experienced an arrhythmia . | NA | {
"id": "C0018799",
"name": "heart disease",
"pos": [
24,
37
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
106,
116
]
} |
fewer side effects , especially reduced blood pressure or the occurrence of postural hypotension , developed during treatment with cu 32-085 . | NA | {
"id": "C0020649",
"name": "reduced blood pressure",
"pos": [
32,
54
]
} | {
"id": "C0020651",
"name": "postural",
"pos": [
76,
84
]
} |
three young children examined after trauma exhibited the characteristic spread appearance of the atlas , but fractures were excluded radiographically and clinically . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
36,
42
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
109,
118
]
} |
there was an association between instability and radial styloid fracture , and in five of nine colles fractures a separate radial styloid fragment was present , suggesting a component of avulsive force . | NA | {
"id": "C0034628",
"name": "radial",
"pos": [
49,
55
]
} | {
"id": "C0009353",
"name": "colles fractures",
"pos": [
95,
111
]
} |
arterial and coronary sinus levels of norepinephrine and epinephrine drawn early in ischemia were not elevated over baseline ; | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
38,
52
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
57,
68
]
} |
variables for the endpoint cardiogenic shock were cardiac arrest , age , congestive heart failure , previous mi , and nodal rhythm . | NA | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
27,
44
]
} | {
"id": "C0027051",
"name": "mi",
"pos": [
109,
111
]
} |
the induced arrhythmias were ventricular tachycardia ( 160 to 300 beats/min ) in 9 and ventricular fibrillation in 1 . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
12,
23
]
} | {
"id": "C0042510",
"name": "ventricular",
"pos": [
87,
98
]
} |
eight of the 23 patients with occlusion arrhythmias and 6 of the 10 with reperfusion arrhythmias had ventricular fibrillation or ventricular tachycardia . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
40,
51
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
101,
125
]
} |
all patients were previously in good health , and cardiac arrest was the initial manifestation of cardiac disease in all . | NA | {
"id": "C0018790",
"name": "cardiac arrest",
"pos": [
50,
64
]
} | {
"id": "C0018799",
"name": "the",
"pos": [
69,
72
]
} |
four patients with ventricular preexcitation whose syncope initially was attributed to an arrhythmia utilizing the accessory pathway are presented . | NA | {
"id": "C0032915",
"name": "ventricular preexcitation",
"pos": [
19,
44
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
90,
100
]
} |
serum levels of the circulating form of vitamin d3 , 25-hydroxycholecalciferol [ 25- ( oh ) d3 ] , were determined in 59 university students , 26 males and 33 females , aged 18 to 26 yr and in 24 elderly subjects , 13 males and 11 females , with a mean age of 62 +/- 13 yr . | NA | {
"id": "C0006657",
"name": "25-hydroxycholecalciferol",
"pos": [
53,
78
]
} | {
"id": "C2713074",
"name": "25",
"pos": [
81,
83
]
} |
no significant differences regarding any of the parameters studied was observed in relationship to the source of dietary protein , but compliance to the regimen was more difficult with the vegetable protein diet . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
113,
128
]
} | {
"id": "C0042439",
"name": "vegetable protein diet",
"pos": [
189,
211
]
} |
two hours from the start of the experiment each subject was given one of the following sugars : glucose , fructose , sucrose , galactose , lactose , or water alone . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
87,
93
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
117,
124
]
} |
indirect immunoperoxidase staining revealed presence of a keratin-type protein in the vast majority of carcinomas , including foci of small cell carcinomas . | NA | {
"id": "C0007097",
"name": "carcinomas",
"pos": [
103,
113
]
} | {
"id": "C0262584",
"name": "small cell carcinomas",
"pos": [
134,
155
]
} |
the segregation of small cell carcinomas from other groups continues to be justified on pragmatic grounds because these carcinomas constitute a group of predominantly small fast-replicating cells amenable to chemotherapy . | NA | {
"id": "C0262584",
"name": "small cell carcinomas",
"pos": [
19,
40
]
} | {
"id": "C0007097",
"name": "carcinomas",
"pos": [
120,
130
]
} |
the sheep red blood cell receptor was not blocked by monoclonal antibodies that bind to the classic t lymphocyte rosette receptor ( okt-11 and lyt-3 ) or by anti-human igg or antilambda antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
53,
74
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
186,
196
]
} |
incubation of whole blood from three asymptomatic hb zurich subjects with pap at a molar ratio of pap/hb of 1.3/1 produced a moderate to marked increase in methemoglobin ( mhb ) and heinz body formation accompanied by a slight to moderate decrease in levels of reduced glutathione . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
50,
52
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
156,
169
]
} |
increased muscle tone and muscular rigidity is frequently encountered in patients with dementia , however , and pathologic reflexes involving neck and proximal musculature have been described in dementia . | NA | {
"id": "C0026826",
"name": "increased muscle tone",
"pos": [
0,
21
]
} | {
"id": "C0026837",
"name": "muscular rigidity",
"pos": [
26,
43
]
} |
we believe that this is the first reported case of aortic insufficiency in systemic-onset juvenile chronic arthritis in which the pathologic condition of the valve can be attributed to the underlying disease . | NA | {
"id": "C0030660",
"name": "pathologic condition",
"pos": [
130,
150
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
200,
207
]
} |
headache intensity and relief scores over the following six hours were obtained and assessed by sums of pain intensity difference and values of pain relief scores analyses . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
0,
8
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
144,
148
]
} |
the current literature on the human pharmacokinetics of nitroglycerin , isosorbide dinitrate , and isosorbide mononitrates is briefly reviewed and evaluated . | NA | {
"id": "C0022252",
"name": "isosorbide dinitrate",
"pos": [
72,
92
]
} | {
"id": "C0064079",
"name": "isosorbide mononitrates",
"pos": [
99,
122
]
} |
the changes in the former are consistent with those previously described as craniotelencephalic dysplasia and those in the latter indicate primary developmental abnormalities of the central nervous system including septo-optic dysplasia , absent olfactory nerves , agenesis of the corpus callosum , and lissencephaly . | NA | {
"id": "C0497552",
"name": "developmental abnormalities of the",
"pos": [
147,
181
]
} | {
"id": "C0338503",
"name": "septo-optic",
"pos": [
215,
226
]
} |
internal anomalies include frequent absence of olfactory bulbs and tracts and dilatation of cerebral ventricles , heart defects ( pda , vsd , stenosis of aortic isthmus ) , hydroureter and hydronephrosis , renal hypoplasia , renal hypoplasia , and rarely renal cysts . | NA | {
"id": "C0018798",
"name": "heart defects",
"pos": [
114,
127
]
} | {
"id": "C0013274",
"name": "pda",
"pos": [
130,
133
]
} |
regulation of human fetal testicular secretion of testosterone : low-density lipoprotein-cholesterol and cholesterol synthesized de novo as steroid precursor . | NA | {
"id": "C0023824",
"name": "low-density",
"pos": [
65,
76
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
105,
116
]
} |
to examine left ventricular function in pregnancy complicated by preeclampsia , echocardiographic dimensions and left ventricular performance indices were determined in 42 preeclamptic patients , 25 normotensive third-trimester patients , and 25 nonpregnant patients . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
40,
49
]
} | {
"id": "C0032981",
"name": "third-trimester",
"pos": [
212,
227
]
} |
concentrations of norepinephrine , epinephrine , and dopamine did not change in the mother or fetus after ketamine , with the exception of maternal levels of epinephrine , which were significantly higher at 45 minutes than control values ( p less than 0.05 ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
18,
32
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
158,
169
]
} |
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