text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
from a cohort study of 120 young ( 18 to 20 years of age ) male military students with low initial refractive error ( less than or equal to +/- 1d , spherical equivalent ) , estimates were made of the short-term ( 5 months ) effect of two forms of optical treatment to prevent school-related myopia . | NA | {
"id": "C0034951",
"name": "refractive error",
"pos": [
99,
115
]
} | {
"id": "C0027092",
"name": "myopia",
"pos": [
292,
298
]
} |
eighty percent of the hormone-dependent tumors and 97 % of the hormone-independent tumors tested elicited angiogenesis . | NA | {
"id": "C0027661",
"name": "hormone-dependent tumors",
"pos": [
22,
46
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
83,
89
]
} |
utilizing dextrans of restricted sizes ( 10,000 , 70,000 , 500,000 daltons ) , modified with regard to charge ( neutral , polycationic , polyanionic ) and an anti-dextran murine iga myeloma , w3129 , the authors have examined a model that may be used in the study of the combined effect of size and charge on renal depos... | NA | {
"id": "C0011806",
"name": "dextrans",
"pos": [
10,
18
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
163,
170
]
} |
the specificity of the antiserum was enhanced by consecutive fibronectin and chondroitin sulfate-dermatan sulfate proteoglycan ( cs-ds proteoglycan ) affinity chromatography . | NA | {
"id": "C0033689",
"name": "chondroitin sulfate",
"pos": [
77,
96
]
} | {
"id": "C0033692",
"name": "proteoglycan",
"pos": [
135,
147
]
} |
carboxypeptidase n ( ec 3.4.12.7 ) ( scpn ) is a plasma enzyme that efficiently inactivates the anaphylatoxins c3a and c4a and significantly reduces c5a spasmogenic activity by removing the c-terminal arginyl residue from each of these factors . | NA | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
96,
110
]
} | {
"id": "C0009510",
"name": "c3a",
"pos": [
111,
114
]
} |
the arginine analog dl-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid ( scpn-inh ) is a potent competitive inhibitor of scpn with a ki for this carboxypeptidase in serum of 2 x 10 ( -9 ) m . | NA | {
"id": "C0007075",
"name": "scpn",
"pos": [
77,
81
]
} | {
"id": "C0054755",
"name": "a",
"pos": [
162,
163
]
} |
when cobra venom factor ( cvf ) is infused into guinea pigs , it activates the alternative pathway of complement , thereby generating the anaphylatoxins c3a and c5a . | NA | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
138,
152
]
} | {
"id": "C0009510",
"name": "c3a",
"pos": [
153,
156
]
} |
in the controlled environment , the following studies were performed : ( 1 ) plasma and urine na+k+ and cl- , ( 2 ) plasma 17-ketosteroid and 17-hydroxysteroids , ( 3 ) plasma cortisol and acth , ( 4 ) urine steroids , ( 5 ) urinary excretion of aldosterone , ( 6 ) plasma activity of the renin ( pra ) in clinostatism a... | NA | {
"id": "C0020393",
"name": "hydroxysteroids",
"pos": [
145,
160
]
} | {
"id": "C0038317",
"name": "steroids",
"pos": [
208,
216
]
} |
when all variable were transformed to z-scores , summed for each subject and categorized by sum into upper and lower 50 % groups by gender , 87.5 % of the females ( n = 16 ) and 80 % of the males ( n = 20 ) were correctly classified as s or f subjects . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
132,
138
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
190,
195
]
} |
based upon a discriminant analysis performed by gender , dev was found to be the only significant predictor for females with dev , slp and wtratio being significant predictors for the males . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
48,
54
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
184,
189
]
} |
steroid secretion rates are based on measuring selected c18 , c19 , and c21 steroids in the venous effluent of testes perfused with a defined medium containing luteinizing hormone . | NA | {
"id": "C0038317",
"name": "steroid",
"pos": [
0,
7
]
} | {
"id": "C0033006",
"name": "c21 steroids",
"pos": [
72,
84
]
} |
these include pregnenolone , 17 alpha-hydroxypregnenolone , dehydroepiandrosterone , androstenediol , progesterone , 17 alpha-hydroxyprogesterone , androstenedione , testosterone , dihydrotestosterone , 3 alpha-androstanediol , and 3 beta-androstanediol . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
14,
26
]
} | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
29,
57
]
} |
vitamin d-deficient rats subjected to thyroparathyroidectomy ( tptx ) were used to evaluate in vivo the biological properties of native bovine parathyroid hormone ( bpth ) and chemically synthesized fragments and analogues of the hormone on several parameters of hormone action : calcium and phosphorus fluxes , generati... | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
396,
416
]
} | {
"id": "C2713074",
"name": "25 ( oh ) d3",
"pos": [
419,
431
]
} |
there was greater net release of phenylalanine , tyrosine , alanine , total nonessential amino acids , total amino acids , potassium , and phosphorus from the perfused hemicorpus of uremic rats and greater release of citrulline from sham rats . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
39,
46
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
109,
120
]
} |
initial coupling occurs between the g/f regulatory protein and the catalytic unit ( naf but not hormonal activation ) followed within hours of birth by coupling to the hormone receptor . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
38,
39
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
84,
87
]
} |
the na+-dependent uptake of citrate by luminal membrane vesicles was influenced by the presence of na+salt anions of different permeabilities in the order : chloride greater than sulfate greater than gluconate . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
107,
113
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
157,
165
]
} |
the na+-dependent uptake of citrate by luminal membrane vesicles was influenced by the presence of na+salt anions of different permeabilities in the order : chloride greater than sulfate greater than gluconate . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
107,
113
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
179,
186
]
} |
urine from normotensive volunteers and patients with systemic lupus erythematosus glomerulonephropathy was sequentially concentrated by negative-pressure ultrafiltration , dialyzed against distilled water , and extracted into the chloroform phase of a mixture of organic solvents ( chloroform : methanol : water , 1:1:0.... | NA | {
"id": "C0790233",
"name": "distilled water",
"pos": [
189,
204
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
306,
311
]
} |
while the activities of complex ii ( succinate-coq reductase ) and iv ( cytochrome c oxidase ) were completely stable , that of complex i ( nadh-coq reductase ) decreased markedly , but largely only after 20 min of ischemia or autolysis . | NA | {
"id": "C0283592",
"name": "complex ii",
"pos": [
24,
34
]
} | {
"id": "C0038615",
"name": "succinate",
"pos": [
37,
46
]
} |
systolic blood pressure in the 6-ohda-treated doca/nacl group ( 139 +/- 4 mmhg ) was lower ( p less than 0.001 ) than in the merlis-doca/nacl group ( 183 +/- 7 mmhg ) . | NA | {
"id": "C0011710",
"name": "doca",
"pos": [
46,
50
]
} | {
"id": "C0813203",
"name": "doca",
"pos": [
132,
136
]
} |
at ta = 20 degrees c the mean increase in metabolic rate was 0.73 w . kg-1 for epinephrine ( 80 micrograms . kg-1 ) , 0.42 w . kg-1 for norepinephrine ( 150 micrograms . kg-1 ) , and 1.16 w . kg-1 for glucagon ( 0.75 micrograms . kg-1 ) ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
79,
90
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
136,
150
]
} |
norepinephrine ( ne ) increased from 139 +/- 24 to 280 +/- 43 pg/ml ( p less than 0.05 , n = 8 ) and epinephrine ( e ) from 70 +/- 26 to 360 +/- 107 pg/ml ( p less than 0.02 , n = 8 ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
101,
112
]
} |
while fetal arterial glucose concentration continued to increase linearly as a function of maternal arterial glucose concentration during maternal hyperglycemia , the umbilical venoarterial difference in blood glucose concentration did not , and umbilical glucose extraction approached a plateau at approximately 0.063 m... | NA | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
201,
217
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
357,
364
]
} |
the authors report the occurrence of a severe confusional state ( dsm-iii delirium ) in a patient who received bilateral sinusoidal ect . | NA | {
"id": "C0009676",
"name": "confusional state",
"pos": [
46,
63
]
} | {
"id": "C0011206",
"name": "delirium",
"pos": [
74,
82
]
} |
it was sensitive to pronase but resistant to glycosidase , phospholipase c , neuraminidase , ribonuclease , and deoxyribonuclease , indicating that it was a protein . | NA | {
"id": "C0017976",
"name": "glycosidase",
"pos": [
45,
56
]
} | {
"id": "C0027803",
"name": "neuraminidase",
"pos": [
77,
90
]
} |
trophoblast membranes were solubilized using three classes of detergents : zwitterionic ( sulfobetaine14 ) , non-ionic ( triton x-100 ) , and anionic ( deoxycholate ) . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
82,
87
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
142,
149
]
} |
the results revealed three major proteins which were identified as placental alkaline phosphatase , albumin , and transferrin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
33,
41
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
100,
107
]
} |
the titer , immunoglobulin class , and staining pattern of smooth muscle antibodies ( sma ) were assayed by indirect immunofluorescence in 15 patients with threatened abortion , 46 patients with spontaneous abortion , and 45 normal pregnant women in the first trimester to investigate possible abnormality of humoral imm... | NA | {
"id": "C0000821",
"name": "threatened abortion",
"pos": [
156,
175
]
} | {
"id": "C0000786",
"name": "spontaneous abortion",
"pos": [
195,
215
]
} |
in eight patients the sinus healed after application of fibrin adhesive , even when a fistula to the vagina was present . | NA | {
"id": "C0016169",
"name": "sinus",
"pos": [
22,
27
]
} | {
"id": "C0042253",
"name": "fistula",
"pos": [
86,
93
]
} |
activated carbon beads in which 5 % activated carbon powder was embedded in 4 % agarose were prepared by the emulsion technique . | NA | {
"id": "C0001275",
"name": "activated carbon",
"pos": [
0,
16
]
} | {
"id": "C0975493",
"name": "activated carbon powder",
"pos": [
36,
59
]
} |
in the assay , production of atp from carbamoyl phosphate and adp by carbamate kinase is coupled to the formation of nadph , using glucose , hexokinase , nadp+ , and glucose-6-phosphate dehydrogenase . | NA | {
"id": "C0006960",
"name": "carbamoyl",
"pos": [
38,
47
]
} | {
"id": "C0006948",
"name": "carbamate",
"pos": [
69,
78
]
} |
effects of chlorphentermine and phentermine on the pulmonary disposition of 5-hydroxytryptamine in the rat in vivo . | NA | {
"id": "C0008283",
"name": "chlorphentermine",
"pos": [
11,
27
]
} | {
"id": "C0031447",
"name": "phentermine",
"pos": [
32,
43
]
} |
further , the effects of cp were compared with those of phentermine ( p ) , the nonchlorinated congener . | NA | {
"id": "C0008283",
"name": "cp",
"pos": [
25,
27
]
} | {
"id": "C0031447",
"name": "phentermine",
"pos": [
56,
67
]
} |
acute febrile neutrophilic dermatosis , so called sweet 's syndrome is a distinct dermatological disease defined by constant clinical and histological features : eruption of painful , tender , raised erythematous plaques of face and neck with fever . | NA | {
"id": "C0037274",
"name": "dermatological disease",
"pos": [
82,
104
]
} | {
"id": "C0015230",
"name": "eruption",
"pos": [
162,
170
]
} |
a variety of cells , endothelial , fibroblastic and smooth muscle are observed next to the pericytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
13,
18
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
35,
47
]
} |
in this study , the amounts of siga and secretory component ( sc ) in oral secretions and sera were measured in 20 patients with oropharyngeal carcinoma and 22 appropriate control subjects in order to elucidate the involvement of the secretory immune system as it related to oropharyngeal carcinoma . | NA | {
"id": "C0020838",
"name": "siga",
"pos": [
31,
35
]
} | {
"id": "C0036538",
"name": "secretory component",
"pos": [
40,
59
]
} |
the most important development in determining successful organ transplantation has been the improved understanding of the immune response and the interactions between antigens , antibody , immune complexes , complement component , lymphocytes and macrophages . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
178,
186
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
189,
205
]
} |
the aminoglycosides , spectinomycin , second and third generation cephalosporins are highly effective and on epidemiological grounds , should replace penicillin as the first choice antibiotic . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
4,
19
]
} | {
"id": "C0001268",
"name": "spectinomycin",
"pos": [
22,
35
]
} |
a disordered sensorium , a cardinal sign of lactic acidosis , is commonly attributed to the acidosis resulting from increased production and decreased utilization of lactate . | NA | {
"id": "C0001125",
"name": "lactic acidosis",
"pos": [
44,
59
]
} | {
"id": "C0001122",
"name": "acidosis",
"pos": [
92,
100
]
} |
240 and 183 strains of non-ppng and ppng isolated in 1981 were studied for their susceptibility to ceftriaxone and cefotaxime respectively . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
99,
110
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
115,
125
]
} |
initial studies indicate that lsa may be a useful marker in cancer of the prostate , bladder , breast , lung , colon , ovary and in leukemia , lymphoma , hodgkins disease and melanoma . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
143,
151
]
} | {
"id": "C0019829",
"name": "hodgkins disease",
"pos": [
154,
170
]
} |
the visceral protein mass is decreased in kwashiorkor and is approximated by study of the liver transport proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
13,
20
]
} | {
"id": "C0007292",
"name": "transport proteins",
"pos": [
96,
114
]
} |
to determine the effect of glucose on the reduced rate of protein and albumin synthesis of fasted rats , free and membrane-bound polyribosomes were isolated quantitatively from liver of starved rats ( 42-66 h ) at different intervals after a single feeding of glucose and after giving glucose ad libitum for 24 h . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
58,
65
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
70,
77
]
} |
these findings suggest that the effect of glucose on the restoration of protein and albumin synthesis is a sole post-transcriptional event . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
72,
79
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
84,
91
]
} |
the adrenal catecholamines ( norepinephrine and epinephrine ) and their conversion enzymes ( pnmt , comt ) were comparatively investigated in : ( 1 ) rats fed a diet deprived of vitamin a , inducing a rapid and severe deficiency ; | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
29,
43
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
48,
59
]
} |
this rabbit antiserum and one of the monoclonal antibodies immunoprecipitated a set of heavy chains not bound by the other 3 antibodies . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
12,
21
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
125,
135
]
} |
this rabbit antiserum and one of the monoclonal antibodies immunoprecipitated a set of heavy chains not bound by the other 3 antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
37,
58
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
125,
135
]
} |
uses of monoclonal antibodies in cancer treatment include the administration of unconjugated antibodies or of antibodies coupled to drugs , toxins , or radioisotopes , and the use of monoclonal antibodies in vitro to eradicate residual malignant cells . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
19,
29
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
183,
204
]
} |
in both sexes , these agents can either cause mucosal urogenital tract infection ( urethritis , cervicitis ) or spread contiguously or hematogenously to produce epididymitis , endometritis , pelvic inflammatory disease or disseminated gonococcal infection . | NA | {
"id": "C0014179",
"name": "endometritis",
"pos": [
176,
188
]
} | {
"id": "C0242172",
"name": "pelvic inflammatory disease",
"pos": [
191,
218
]
} |
separation of the main components of the nebramycin complex of apramycin , kanamycin b and tobramycin was achieved in the form of their 2,4-dinitrophenyl derivatives . | NA | {
"id": "C0027521",
"name": "nebramycin",
"pos": [
41,
51
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
91,
101
]
} |
the following biochemical indices were determined : the level of total protein , the ratio of the protein fractions ( albumins , alpha 1- , alpha 2 , beta- and gamma-globulins ) , the contents of urea , urea nitrogen , residual nitrogen , total , free and bound cholesterol . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
71,
78
]
} | {
"id": "C0001924",
"name": "albumins",
"pos": [
118,
126
]
} |
the effect of doxorubicin , carminomycin and rubomycin on some immunological reactions was studied comparatively on mice . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
14,
25
]
} | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
45,
54
]
} |
the effect of doxorubicin , carminomycin and rubomycin on some immunological reactions was studied comparatively on mice . | NA | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
28,
40
]
} | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
45,
54
]
} |
[ effect of rubomycin and carminomycin on suppressor cells participating in the regulation of the immune response ] . | NA | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
12,
21
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
26,
38
]
} |
the effect of rubomycin and carminomycin on induction of suppressor cells in immunization of mice with high doses ( 2 . 10 ( 9 ) cells ) of sheep red blood cells ( srbc ) or with the allogeneic spleen cells was studied . | NA | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
14,
23
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
28,
40
]
} |
the effect of rubomycin and carminomycin on induction of suppressor cells in immunization of mice with high doses ( 2 . 10 ( 9 ) cells ) of sheep red blood cells ( srbc ) or with the allogeneic spleen cells was studied . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
68,
73
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
183,
193
]
} |
cephamycins , which have a methoxy group at the 7 alpha position of their cephalosporin nuclei , were highly stable against hydrolysis by a beta-lactamase purified from a clinical isolate of morganella morganii , whereas their 7 alpha-h analogs were rapidly hydrolyzed by the enzyme . | NA | {
"id": "C0007736",
"name": "cephamycins",
"pos": [
0,
11
]
} | {
"id": "C3536856",
"name": "cephalosporin",
"pos": [
74,
87
]
} |
these 7 alpha-substituted cephalosporins , except for cephamycins , also had greatly reduced affinities for target proteins , i.e. , penicillin-binding proteins , of beta-lactam antibiotics . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
26,
40
]
} | {
"id": "C0007736",
"name": "cephamycins",
"pos": [
54,
65
]
} |
in contrast , delta psi was -142 mv anaerobically , gentamicin uptake was essentially nonexistent , and the aminoglycoside had no effect on viability . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
52,
62
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
108,
122
]
} |
79:6693-6697 , 1982 ) , indicating that the relationship between delta psi and gentamicin uptake is gated , and suggest that diminution of delta psi may be an important factor in aminoglycoside resistance under anaerobic conditions . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
79,
89
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
179,
193
]
} |
the pp n. gonorrhoeae isolates were extremely susceptible to ceftriaxone , ceftizoxime , and cefotaxime , highly susceptible to moxalactam and cefoperazone , and less susceptible to cefoxitin , ceforanide , and cefonicid ( geometric mean minimal inhibitory concentrations were 0.002 , 0.003 , 0.007 , 0.03 , 0.07 , 0.6 ,... | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
61,
72
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
93,
103
]
} |
the pp n. gonorrhoeae isolates were extremely susceptible to ceftriaxone , ceftizoxime , and cefotaxime , highly susceptible to moxalactam and cefoperazone , and less susceptible to cefoxitin , ceforanide , and cefonicid ( geometric mean minimal inhibitory concentrations were 0.002 , 0.003 , 0.007 , 0.03 , 0.07 , 0.6 ,... | NA | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
75,
86
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
93,
103
]
} |
although this in vitro study showed pp n. gonorrhoeae isolates to be comparatively more susceptible to ceftriaxone , ceftizoxime , and cefotaxime than to the other antibiotics , these results may not correlate with clinical efficacy . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
103,
114
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
135,
145
]
} |
although this in vitro study showed pp n. gonorrhoeae isolates to be comparatively more susceptible to ceftriaxone , ceftizoxime , and cefotaxime than to the other antibiotics , these results may not correlate with clinical efficacy . | NA | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
117,
128
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
135,
145
]
} |
we have shown that thienamycin , penicillin g , and ampicillin are the most active beta-lactam antibiotics against listeria spp . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
33,
45
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
52,
62
]
} |
moxalactam was used as initial , empirical therapy in 69 patients with a variety of serious bacterial infections , 32 % of which were accompanied by bacteremia . | NA | {
"id": "C0004623",
"name": "bacterial infections",
"pos": [
92,
112
]
} | {
"id": "C0004610",
"name": "bacteremia",
"pos": [
149,
159
]
} |
pseudomonas stutzeri and paracoccus denitrificans rapidly reduced nitrate , nitrite , and nitrous oxide and were able to grow anaerobically when any of these nitrogen oxides were present in the medium . | NA | {
"id": "C0028215",
"name": "nitrous oxide",
"pos": [
90,
103
]
} | {
"id": "C0028167",
"name": "of",
"pos": [
149,
151
]
} |
the regulation of glucose 6-phosphatase in hepatic microsomes by thyroid and corticosteroid hormones has been studied following the administration of 3,3',5-triiodo-l-thyronine and/or triamcinolone to hypophysectomized rats . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
77,
91
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
92,
100
]
} |
the ph profiles for the dissociation constants of iodoacetate from the free enzyme and the enzyme-imidazole complex and of imidazole from the free enzyme and the binary enzyme-iodoacetate complex were determined . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
76,
82
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
169,
175
]
} |
when allophycocyanin 's nonexchangeable hydrogens were replaced by deuteriums , it was more readily dissociated to monomers . | NA | {
"id": "C0020275",
"name": "hydrogens",
"pos": [
40,
49
]
} | {
"id": "C0011744",
"name": "deuteriums",
"pos": [
67,
77
]
} |
we report in this manuscript that glutamic acid , glutamine , aspartic acid , and gamma-aminobutyric acid as well as inorganic phosphate and adenosine nucleotides are also active components of the heat-stable factor . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
34,
47
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
50,
59
]
} |
the medium-chain acyl-coa ester fraction was increased whereas coenzyme a ( coa ) , acetyl-coa , and the long chain acyl-coa fractions were decreased by valproic acid . | NA | {
"id": "C0009226",
"name": "coenzyme a",
"pos": [
63,
73
]
} | {
"id": "C0001374",
"name": "acyl-coa",
"pos": [
116,
124
]
} |
the medium-chain acyl-coa ester fraction was increased whereas coenzyme a ( coa ) , acetyl-coa , and the long chain acyl-coa fractions were decreased by valproic acid . | NA | {
"id": "C0001026",
"name": "acetyl-coa",
"pos": [
84,
94
]
} | {
"id": "C0001374",
"name": "acyl-coa",
"pos": [
116,
124
]
} |
not only the overall reaction of enzyme complex but the individual reactions catalyzed by enzyme components , pyruvate dehydrogenase , and dihydrolipoamide acetyltrasferase , were reduced after preincubation . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
33,
47
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
90,
96
]
} |
a total of 130 patients with melanocytic nevus and 427 cases of melanoma without histologic evidence of a nevus ( denovo ) were studied . | NA | {
"id": "C0027962",
"name": "melanocytic nevus",
"pos": [
29,
46
]
} | {
"id": "C0027960",
"name": "nevus",
"pos": [
106,
111
]
} |
the therapeutic response was more complete in the seven patients with psoriatic arthritis than in in six subjects with uncomplicated psoriasis . | NA | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
70,
89
]
} | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
133,
142
]
} |
the cellular localization of glial s-100 protein was investigated in paraffin-embedded sections of cutaneous histiocytosis x and in a variety of cutaneous infiltrative disorders , including juvenile xanthogranuloma , necrobiotic xanthogranuloma , papular xanthoma , eruptive histiocytoma , and reticulohistiocytosis . | NA | {
"id": "C0019621",
"name": "histiocytosis x",
"pos": [
109,
124
]
} | {
"id": "C0019618",
"name": "reticulohistiocytosis",
"pos": [
294,
315
]
} |
venous blood mononuclear cells from 42 children with primary immunodeficiency disorders and from controls matched for age were studied for lymphocyte subpopulations by e rosetting , surface immunoglobulin , and a panel of anti t cell monoclonal antibodies ( okt series ) . | NA | {
"id": "C1321301",
"name": "blood mononuclear cells",
"pos": [
7,
30
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
229,
233
]
} |
her life began in vienna as the youngest child of sigmund freud , and her early work with children was in austria . | NA | {
"id": "C0728836",
"name": "youngest child of",
"pos": [
32,
49
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
90,
98
]
} |
fn was also observed on the surface of both fibroblast-like and macrophage-like pannus cells , suggesting that it was secreted by these cells and that the secreted fn might facilitate the spreading of the pannus cells over the cartilage matrix . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
44,
54
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
212,
217
]
} |
individuals who have suffered severe trauma , such as burns , have a high incidence of infection associated with impaired host resistance . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
37,
43
]
} | {
"id": "C0006434",
"name": "burns",
"pos": [
54,
59
]
} |
although coronary vasospasm has not been clearly documented in patients with recurrent rest angina after infarction , a primary decrease in coronary blood flow is the most likely cause of this syndrome since the ischemia occurs at rest , at a time when myocardial oxygen demands are not elevated . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
105,
115
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
212,
220
]
} |
sixty patients without organic heart disease presenting with chest pain suggestive of angina pectoris and angiographically normal coronary arteries underwent clinical , hemodynamic and metabolic investigation . | NA | {
"id": "C0008031",
"name": "chest pain",
"pos": [
61,
71
]
} | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
86,
101
]
} |
these results confirm that about 30 per cent of patients investigated for chest pain suggestive of angina pectoris who have angiographically normal coronary arteries , develop signs of myocardial ischemia during atrial pacing . | NA | {
"id": "C0008031",
"name": "chest pain",
"pos": [
74,
84
]
} | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
99,
114
]
} |
however , it may give risk to hypo or hyperthyroidism and so , should not be used in patients with a history or thyroid disorders . | NA | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
38,
53
]
} | {
"id": "C0040128",
"name": "thyroid",
"pos": [
112,
119
]
} |
the electron microscopic examination of two cases of lymphomatoid papulosis revealed a mixed cellular infiltrate consisting of lymphoid cells with t-cell features , histiocyte-like cells and some fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
136,
141
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
196,
207
]
} |
the trichothecenes nivalenol , fusarenon-x and t-2 toxin provoked a marked toxicity as especially expressed by cell cycle delay . | NA | {
"id": "C0040952",
"name": "trichothecenes",
"pos": [
4,
18
]
} | {
"id": "C0039185",
"name": "t-2",
"pos": [
47,
50
]
} |
the cellular sensitization of the tumor-bearer was not correlated with the localization and the histologic type of the tumor . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
34,
39
]
} | {
"id": "C0027652",
"name": "histologic type of",
"pos": [
96,
114
]
} |
patients with pain of more than a year 's duration , who had undergone multiple surgical operations for pain control , who used tranquilizers , or who were not working because of pain , demonstrated a generally lower rate of treatment success , although the differences were not statistically significant . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
14,
18
]
} | {
"id": "C0474368",
"name": "working",
"pos": [
160,
167
]
} |
plain skull x-rays showed fractures in only 2 patients and in 6 cases trivial head injuries indicated a more severe trauma . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
26,
35
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
116,
122
]
} |
the permeability and level of energy supply of transendothelial transport were found to depend on the kind of the main pathological process and type of death . | NA | {
"id": "C0030660",
"name": "pathological process",
"pos": [
119,
139
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
152,
157
]
} |
the variables significantly associated with the presence of ocular hypertension were family history of glaucoma , myopic refractive error , absence of liquor intake , history of nonocular surgery , high income , and history of high bp . | NA | {
"id": "C0027092",
"name": "myopic",
"pos": [
114,
120
]
} | {
"id": "C0034951",
"name": "refractive error",
"pos": [
121,
137
]
} |
in the present work we compare the properties of the unmodified and two major modified isozymes , which collectively account for 90 % of the hgprt enzyme activity in cell lysates . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
87,
95
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
147,
153
]
} |
in a previous report we provided evidence that the three major hypoxanthine-guanine phosphoribosyltransferase ( hgprt ; ec 2.4.2.8 ) isozymes in human erythroid cells are derived by posttranslational modification of a single enzyme [ johnson , g . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
133,
141
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
225,
231
]
} |
in the experiments reported here we provide further evidence that the modified isozymes have a catalytic activity that is at least as great as that of the unmodified enzyme . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
79,
87
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
166,
172
]
} |
employing the dihydrostreptomycin sensitivity of the moda gene product , it is shown that the moda gene controls the synthesis of one of these proteins ( laccase iii ) at a posttranscriptional level . | NA | {
"id": "C0033684",
"name": "gene product",
"pos": [
58,
70
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
117,
126
]
} |
we have found that the m activity is carried by a major membrane glycoprotein that is similar but not identical to the human mm glycoprotein ( glycophorin a ) . | NA | {
"id": "C0025248",
"name": "membrane glycoprotein",
"pos": [
56,
77
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
128,
140
]
} |
structural similarities to the human antigens strongly suggest that the amino terminus bears the major antigenic determinants of the molecule , and the occurrence in this region of numerous , albeit rare , variants among humans and in chimpanzees indicates that the corresponding coding sequence of the structural gene i... | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
37,
45
]
} | {
"id": "C0003316",
"name": "antigenic",
"pos": [
103,
112
]
} |
binding of thyroxine to the nuclear non-histone protein and induction of mitochondrial alpha-glycerophosphate dehydrogenase activity . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
28,
35
]
} | {
"id": "C0019652",
"name": "histone",
"pos": [
40,
47
]
} |
after administration of 2.4 micrograms of t4/100 g body weight to hypothyroid rats for 7 days , t4 and t3 concentrations in serum and in the liver nuclear non-histone protein ( nhp ) were all increased to the hyperthyroid range . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
147,
154
]
} | {
"id": "C0019652",
"name": "histone",
"pos": [
159,
166
]
} |
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