text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in rat lungs perfused in situ with krebs-henseleit bicarbonate buffer containing 4.5 % ( w/v ) bovine serum albumin , 5.6 mm-glucose , plasma concentrations of 19 amino acids and 690 microm- [ u-14c ] -phenylalanine and equilibrated with o2/n2/co2 ( 4:15:1 ) , protein synthesis , calculated based on the specific radioa... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
163,
174
]
} | {
"id": "C0035714",
"name": "aminoacyl-trna",
"pos": [
331,
345
]
} |
the addition of ionophore a23187 to the atpase assay , to allow continuous ca2+ recycling during the assay time , reveals the presence of a substantial ca2+-stimulated atpase with vmax . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
40,
46
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
152,
155
]
} |
enzyme activity and radioactivity were cleared from plasma identically , with first-order kinetics , with a half-life of about 30 min . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
90,
98
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
108,
117
]
} |
affinity labelling of the membrane proteins using [ 3h ] bilirubin-woodward 's reagent k complex did not define individual proteins . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
26,
43
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
123,
131
]
} |
replacement of rat blood with defined perfusion media deprived the liver of rat serum proteins ( albumin , immunoglobulin a ) and resulted in a rapid decline in the amounts of these proteins in bile . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
97,
104
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
182,
190
]
} |
after fractionation of rabbit bone marrow into dividing ( early ) and non-dividing ( late ) erythroid cells , the adenylate cyclase activity of membrane ghosts was assayed in the presence of guanine nucleotides ( ( gtp and its analogue p [ nh ] ppg ( guanosine 5'- [ beta , gamma-imido ] triphosphate ) ) ) , the beta-ad... | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
191,
210
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
215,
218
]
} |
no significant change in binding affinity for gtp and p [ nh ] ppg during erythroblast development was observed : the dissociation constants of both guanine nucleotides were almost identical with early and late erythroblast membrane preparations [ 2-3 ( x 10 ( -7 ) m ] . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
46,
49
]
} | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
149,
168
]
} |
the non-metabolizable amino acids alpha-aminoisobutyric acid ( aib ) and cycloleucine and the poorly metabolizable amino acid d-alanine potently stimulated hepatic ornithine decarboxylase ( odc ) activity in starved rats . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
22,
32
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
128,
135
]
} |
gsh peroxidase , gssg reductase , gsh s-transferase , and gamma-glutamyltranspeptidase activities were measured in the supernatant of 13 human early pregnancy placenta homogenates . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
17,
21
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
34,
37
]
} |
the metabolism of collagen in male rats by treatment with bleomycin was studied following the injection of [ 3h ] proline and the determination of specific and total activity of [ 3h ] hydroxyproline in skin collagen fractions and urine . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
114,
121
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
185,
199
]
} |
it was found that this was accompanied by a decrease in urinary excretion of total hydroxyproline and [ 3h ] hydroxyproline during the first 12 hr after the administration of [ 3h ] proline . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
83,
97
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
182,
189
]
} |
tmpyp and its ni derivative increase the viscosity of linear dna , cause unwinding and reverse coiling of superhelical dna , and induce a separate downfield peak in the 31p nmr spectrum of dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
61,
64
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
191,
192
]
} |
since the synthesized proteins include cytosolic precursors of mitochondrial proteins , our results strongly suggest that import of proteins from the cytosol into mitochondria influences the half-life of proteins in these organelles . | NA | {
"id": "C0949610",
"name": "mitochondrial proteins",
"pos": [
63,
85
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
204,
212
]
} |
we have tested this hypothesis by manipulating the fatty acid composition of an escherichia coli mutant that is unable to synthesize unsaturated fatty acids . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
51,
61
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
133,
156
]
} |
the plasma concentration of pcp in rats with napcp ( 1.4 mm ) in their drinking water was highest ( 270 microm ) in the period that the animals were kept in the dark and consumed food and water . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
71,
85
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
188,
193
]
} |
influence of hypoxia on the metabolism and excretion of misonidazole by the isolated perfused rat liver -- a model system . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
28,
38
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
43,
52
]
} |
the intracellular levels of s-adenosylhomocysteine ( sah ) , an inhibitor of sam-mediated methylations , were increased by adding adenosine ( 100 microm ) , l-homocysteine thiolactone ( l-hct , 10 microm ) , and erythro-9- ( 2-hydroxy-3-nonyl ) -adenine ( ehna , 10 microm ) , an inhibitor of adenosine deaminase , to hu... | NA | {
"id": "C0036002",
"name": "an",
"pos": [
61,
63
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
293,
302
]
} |
one group of macrolides including previously studied compounds ( oleandomycin , erythromycin and troleandomycin ) , as well as several other erythromycin derivatives , showed induction of microsomal enzymes and formation of inactive cytochrome p-450-metabolite complexes in vivo ; | NA | {
"id": "C0028923",
"name": "oleandomycin",
"pos": [
65,
77
]
} | {
"id": "C0041165",
"name": "troleandomycin",
"pos": [
97,
111
]
} |
this formation increased in the order : oleandomycin , erythromycin ethylsuccinate , erythromycin stearate , erythromycin itself , erythromycin propionate , erythromycin estolate and troleandomycin . | NA | {
"id": "C0028923",
"name": "oleandomycin",
"pos": [
40,
52
]
} | {
"id": "C0041165",
"name": "troleandomycin",
"pos": [
183,
197
]
} |
this formation increased in the order : oleandomycin , erythromycin ethylsuccinate , erythromycin stearate , erythromycin itself , erythromycin propionate , erythromycin estolate and troleandomycin . | NA | {
"id": "C0014810",
"name": "erythromycin ethylsuccinate",
"pos": [
55,
82
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
157,
169
]
} |
this formation increased in the order : oleandomycin , erythromycin ethylsuccinate , erythromycin stearate , erythromycin itself , erythromycin propionate , erythromycin estolate and troleandomycin . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
55,
67
]
} | {
"id": "C0014809",
"name": "erythromycin estolate",
"pos": [
157,
178
]
} |
troleandomycin and , to a lesser extent , erythromycin and oleandomycin formed cytochrome p-450-metabolite complexes when incubated in vitro with 1 mm nadph and microsomes from rats pretreated with troleandomycin or phenobarbital , but not with microsomes from control rats or rats treated with 3-methylcholanthrene . | NA | {
"id": "C0028923",
"name": "oleandomycin",
"pos": [
2,
14
]
} | {
"id": "C0041165",
"name": "troleandomycin",
"pos": [
198,
212
]
} |
serum beta-2-microglobulin ( beta 2m ) levels , incidence and levels of anti-beta 2m autoantibodies , and quantity of circulating macromolecular complexes containing beta 2m were studied in patients with felty 's syndrome ( fs ) , joint-restricted rheumatoid arthritis ( ra ) , and healthy controls . | NA | {
"id": "C0015773",
"name": "felty 's syndrome",
"pos": [
204,
221
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
248,
268
]
} |
circulating complexes containing beta 2m , prepared by precipitation in 3 % polyethylene glycol , were detected in 65 % of fs and 35 % of ra patients . | NA | {
"id": "C0015773",
"name": "fs",
"pos": [
123,
125
]
} | {
"id": "C0003873",
"name": "ra",
"pos": [
138,
140
]
} |
detection of anti-beta 2m antibodies in a significant part of complexes containing beta 2m suggests the presence of specific immune complexes in this fraction of fs and ra patients . | NA | {
"id": "C0015773",
"name": "fs",
"pos": [
162,
164
]
} | {
"id": "C0003873",
"name": "ra",
"pos": [
169,
171
]
} |
apolipoproteins ( apo a-1 and apo b ) were measured by rocket immunoelectrophoresis in 53 patients 40-59 years of age with coronary heart disease . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
0,
15
]
} | {
"id": "C0003593",
"name": "apo b",
"pos": [
30,
35
]
} |
ls fibroblasts grown in suspension culture fix c3 on their surface when they are incubated with human or guinea pig complement as shown by reacting te cells with fitc-labelled anti c3c sera or immunoglobulins . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
3,
14
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
151,
156
]
} |
ccl4 does not enhance the decrease in total glutathione ( tg ) during the incubation time , so gsh loss is mainly due to its oxidation to gssg . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
95,
98
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
138,
142
]
} |
lipid peroxidation seems to have a great importance in the kinetics of gsh decrease and gssg formation , at least `` '' in vitro '' '' . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
71,
74
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
88,
92
]
} |
4 ) as to relation of sss to seizure types of epilepsy , complex partial seizures showed significantly higher incidence of sss ( 25.2 % ) than simple partial seizures ( 7.5 % ) and generalized tonic-clonic seizures ( 6.5 % ) . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
29,
36
]
} | {
"id": "C0014544",
"name": "types",
"pos": [
37,
42
]
} |
evaluation of cumulative properties of three new nondepolarizing neuromuscular blocking drugs bw a444u , atracurium and vecuronium . | NA | {
"id": "C2917437",
"name": "nondepolarizing neuromuscular",
"pos": [
49,
78
]
} | {
"id": "C0242531",
"name": "vecuronium",
"pos": [
120,
130
]
} |
the interaction of three new non-depolarizing neuromuscular blocking agents -- atracurium , vecuronium and duador -- on human red cell acetylcholinesterase ( ache ; ec 3.1.1.7 ) and human plasma butyrylcholinesterase ( buche ; ec 3.1.1.8 ) was investigated . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
135,
155
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
195,
216
]
} |
the neuromuscular effects of three new nondepolarizing neuromuscular blocking drugs , atracurium , vecuronium and duador , were investigated in surgical patients under balanced anaesthesia . | NA | {
"id": "C2917437",
"name": "neuromuscular",
"pos": [
4,
17
]
} | {
"id": "C0242531",
"name": "vecuronium",
"pos": [
99,
109
]
} |
we describe two patients who developed generalized pustular psoriasis after taking phenylbutazone and oxyphenbutazone respectively , and discuss the possible pharmacological mechanism of this effect . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
83,
97
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
102,
117
]
} |
as leukaemic cells differentiated along myeloid ( acute promyelocytic ) or monocytoid ( acute myelomonocytic ) pathways , their cholesterol-synthetic rates diverged and approached those of their respective mature cellular counterparts , the neutrophil or the peripheral blood monocyte . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
213,
221
]
} | {
"id": "C1321301",
"name": "peripheral blood monocyte",
"pos": [
259,
284
]
} |
the phenylalanyl-trna synthetases from escherichia coli , saccharomyces cerevisiae , neurospora crassa , and turkey liver activate a number of phenylalanine analogues ( tyrosine , leucine , methionine , p-fluorophenylalanine , beta-phenylserine , beta-thien-2-ylalanine , 2-amino-4-methylhex-4-enoic acid , mimosine , n-... | NA | {
"id": "C0030137",
"name": "p-fluorophenylalanine",
"pos": [
203,
224
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
344,
357
]
} |
however , the data suggest that the cleavage of hmg-coa is at least partially reversible and indicate that enolization of acetyl-coa may be dependent upon a conformational change of hmg-coa lyase , induced by binding of acetoacetate , in a manner analogous to the keto acid dependent tritium exchange catalyzed by malate... | NA | {
"id": "C0000988",
"name": "acetoacetate",
"pos": [
220,
232
]
} | {
"id": "C0022618",
"name": "keto acid",
"pos": [
264,
273
]
} |
removal of purine bases from phi x174 single-stranded dna leads to increased reversion frequency of amber mutations when this dna is copied in vitro with purified dna polymerases . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
38,
57
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
163,
166
]
} |
fate of an intervening sequence ribonucleic acid : excision and cyclization of the tetrahymena ribosomal ribonucleic acid intervening sequence in vivo . | NA | {
"id": "C0035668",
"name": "ribonucleic acid",
"pos": [
32,
48
]
} | {
"id": "C0035701",
"name": "ribosomal ribonucleic acid",
"pos": [
95,
121
]
} |
we conclude that splicing is not a rate-limiting step in rrna maturation and that the ivs rna is quickly degraded after its excision . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
57,
61
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
90,
93
]
} |
the isoenzyme differs by only four residues from the most abundant enzyme , lacking the carboxylate at position 71 ( asn for glu ) . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
4,
13
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
67,
73
]
} |
the results strongly support the notion that the nicotinic acchr contains multiple binding sites for cholinergic ligands . | NA | {
"id": "C0034830",
"name": "nicotinic acchr",
"pos": [
49,
64
]
} | {
"id": "C0034792",
"name": "binding sites",
"pos": [
83,
96
]
} |
the inactivation is highly specific since pyridoxine and pyridoxamine 5'-phosphate , analogues of pyridoxal 5'-phosphate , which lack an aldehyde group , caused little or no inhibition even at high concentrations . | NA | {
"id": "C0034272",
"name": "pyridoxine",
"pos": [
42,
52
]
} | {
"id": "C0034266",
"name": "pyridoxal 5",
"pos": [
98,
109
]
} |
selected nucleoside 5'-triphosphates were converted to 2',5'-oligonucleotides with the following order of efficiency for the nucleoside : 8-azaadenosine greater than adenosine = 2-chloroadenosine greater than sangivamycin greater than toyocamycin greater than formycin greater than 3-ribosyladenine greater than ribaviri... | NA | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
178,
195
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
524,
533
]
} |
sarcoplasmic reticulum calcium adenosinetriphosphatase ( ca2+-atpase ) was solubilized to monomeric form with the nonionic detergent n-dodecyl octaethylene glycol monoether ( c12e8 ) . | NA | {
"id": "C0916181",
"name": "sarcoplasmic reticulum calcium adenosinetriphosphatase",
"pos": [
0,
54
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
57,
60
]
} |
zwittergent 3-12 solubilizes free chains of heparan sulfate but not heparan sulfate proteoglycan from either class of sites . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
44,
59
]
} | {
"id": "C0062503",
"name": "heparan sulfate proteoglycan",
"pos": [
68,
96
]
} |
the pure enzyme was able to reduce fad , fmn , riboflavin , flavodoxin isolated from megasphaera elsdenii , menadione and horse heart cytochrome c as well as various artificial electron acceptors . | NA | {
"id": "C0016388",
"name": "fmn",
"pos": [
41,
44
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
47,
57
]
} |
270 mhz 1h-nmr studies establish that cys-4 and methylamide nh groups are solvent-shielded , using hydrogen-deuterium exchange , solvent and temperature dependence of chemical shifts and nitroxide radical-induced broadening as diagnostic criteria . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
99,
107
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
108,
117
]
} |
the perfused heart efficiently extracted and metabolized unesterified fatty acid and the fatty acid released during lipolysis of the recirculating triacylglycerol . | NA | {
"id": "C0015688",
"name": "unesterified fatty acid",
"pos": [
57,
80
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
89,
99
]
} |
on the basis of these results , we propose that the pattern of 18-carbon unsaturated fatty acids in the triacylglycerols of all 'oil'-producing seeds is a direct reflection of the fatty acids in the acyl-coa pool . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
73,
96
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
180,
191
]
} |
specific radioactivity determinations showed that lymph c-iii-0 , c-iii-3 , and c-iii-2,1 apolipoproteins rapidly reached values identical to those of corresponding plasma c apolipoproteins and the interrelationship between the curves were consistent with precursor-product relationships in which all , or most , of the ... | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
90,
105
]
} | {
"id": "C0003594",
"name": "c apolipoproteins",
"pos": [
172,
189
]
} |
specific radioactivity determinations showed that lymph c-iii-0 , c-iii-3 , and c-iii-2,1 apolipoproteins rapidly reached values identical to those of corresponding plasma c apolipoproteins and the interrelationship between the curves were consistent with precursor-product relationships in which all , or most , of the ... | NA | {
"id": "C0003594",
"name": "c apolipoproteins",
"pos": [
172,
189
]
} | {
"id": "C0052191",
"name": "apolipoprotein c-iii",
"pos": [
336,
356
]
} |
these data suggest that protease-antiprotease complexes are associated with bronchial mucins and that reducing agents or apma activate proteases . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
24,
32
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
135,
144
]
} |
the biologic properties of two major proteoglycans of bovine aorta , heparan sulfate proteoglycan and chondroitin sulfate-dermatan sulfate proteoglycan were compared . | NA | {
"id": "C0033692",
"name": "proteoglycans",
"pos": [
37,
50
]
} | {
"id": "C0033689",
"name": "chondroitin sulfate",
"pos": [
102,
121
]
} |
twelve acutely manic patients , newly admitted from the emergency room , were treated wih clonazepam or lithium carbonate in a double-blind cross-over design : half the patients chosen randomly received 10 days of treatment with clonazepam followed immediately by 10 days of treatment with lithium , while the others rec... | NA | {
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
104,
121
]
} | {
"id": "C0023870",
"name": "lithium",
"pos": [
290,
297
]
} |
this was partially confirmed by the present study , and leads to the hypothesis that excitation of seizure-inhibiting activity , including activity of the dopamine system , may be related to the emergence of a psychotic state , and to the inverse relationship between epilepsy and the psychotic state in temporal lobe ep... | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
99,
106
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
318,
326
]
} |
it is thought that in order for copper to bind with the same number of sites as does occur with nickel , ligands of the form cucl-cucl2 are generated . | NA | {
"id": "C0009968",
"name": "copper",
"pos": [
32,
38
]
} | {
"id": "C0056593",
"name": "cucl2",
"pos": [
130,
135
]
} |
castration produced a significant reduction in the levels of reduced ( gsh ) and oxidized ( gssg ) glutathione and glutathione reductase activity in the prostate . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
92,
96
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
115,
126
]
} |
the number of colonies per 10 ( 6 ) lymphocytes plated ( corrected colony count , cc ) was significantly higher when 2.5 x 10 ( 5 ) or less pb mnc were cultured than when 5 or 10 x 10 ( 5 ) cells were cultured . | NA | {
"id": "C1321301",
"name": "pb mnc",
"pos": [
140,
146
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
190,
195
]
} |
as dopamine and homovanillic acid concentrations were not altered in these csf samples , this finding of reduced cgmp suggests a cholinergic-dopaminergic imbalance in schizophrenia , with a reduction of the former and consequently a relative dominance of the latter . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
3,
11
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
141,
153
]
} |
of those interviewed , none fulfilled diagnostic criteria for anorexia nervosa , but half showed eating disorder of clinical severity . | NA | {
"id": "C0003125",
"name": "anorexia nervosa",
"pos": [
62,
78
]
} | {
"id": "C0013473",
"name": "eating disorder",
"pos": [
97,
112
]
} |
birth weight , placental weight , head circumference , and apgar score were not significantly different and there were no stillbirths in either group . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
0,
12
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
25,
31
]
} |
chest wall mapping of st segment changes , inverted u waves , and q waves using 16 electrocardiographic electrodes was performed at rest and during and after bicycle ergometry in 150 patients presenting with chest pain suggestive of angina . | NA | {
"id": "C0008031",
"name": "chest pain",
"pos": [
208,
218
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
233,
239
]
} |
forty four babies , of less than 32 weeks ' gestation , were either randomly given 25 mg/kg vitamin e ( dl-alpha-tocopherol acetate ) intramuscularly after birth ( day 0 ) and on days 1 , 2 , and 3 or served as controls . | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
92,
101
]
} | {
"id": "C0994472",
"name": "dl-alpha-tocopherol acetate",
"pos": [
104,
131
]
} |
the neuronotrophic factors appeared to be proteins immunologically distinct from mouse submaxillary nerve growth factor . | NA | {
"id": "C0027754",
"name": "neuronotrophic factors",
"pos": [
4,
26
]
} | {
"id": "C0027752",
"name": "nerve growth factor",
"pos": [
100,
119
]
} |
endogenous levels of putative amino acid neurotransmitters ( glycine , glutamic acid , aspartic acid , and gaba ) in medial and sulcal prefrontal cortex of the rat were analyzed using gas liquid chromatography . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
30,
40
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
61,
68
]
} |
circulating norepinephrine ( ne ) and epinephrine ( e ) levels were used as indices of sympathetic fiber and adrenal medulla activities , respectively , under basal conditions and during a 1-min bilateral carotid occlusion ( co ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
12,
26
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
38,
49
]
} |
it is concluded that calcium carbimide is a more specific inhibitor of hepatic aldehyde dehydrogenase enzymes than disulfiram . | NA | {
"id": "C2917344",
"name": "inhibitor",
"pos": [
58,
67
]
} | {
"id": "C0012772",
"name": "disulfiram",
"pos": [
115,
125
]
} |
these seizures precede and differ in motor seizure pattern from a second clonic-tonic seizure produced by hyperthermia in both epileptic and carrier ( heterozygote , epi , epi ) chicks . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
6,
14
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
127,
136
]
} |
these data suggest that epileptic chicks may provide a suitable model for studies on febrile convulsions . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
24,
33
]
} | {
"id": "C0009952",
"name": "febrile convulsions",
"pos": [
85,
104
]
} |
intussusception in the newborn is a unique clinical entity , and one of the most unusual causes of intestinal obstruction in infants . | NA | {
"id": "C0021933",
"name": "intussusception",
"pos": [
0,
15
]
} | {
"id": "C0021843",
"name": "of",
"pos": [
96,
98
]
} |
there are three reported cases of young children with pericardial effusion as the initial manifestation of acute lymphocytic leukemia , but no reported cases due to nonlymphocytic leukemia , as in this child . | NA | {
"id": "C0728836",
"name": "of young children",
"pos": [
31,
48
]
} | {
"id": "C0008059",
"name": "child",
"pos": [
202,
207
]
} |
the diagnosis of glioblastoma multiforme ( gbm ) was made only when one or more foci of coagulation necrosis involving astrocytic tumor cells were identified histologically . | NA | {
"id": "C0017636",
"name": "glioblastoma multiforme",
"pos": [
17,
40
]
} | {
"id": "C0004114",
"name": "astrocytic tumor",
"pos": [
119,
135
]
} |
the secretion of human chorionic gonadotropin and its subunits was examined by a heterologous hcg/hcg-beta radioimmunoassay and homologous radioimmunoassays of the alpha- and beta-subunit in patients with nonseminomatous testicular germ cell tumors . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotropin",
"pos": [
17,
45
]
} | {
"id": "C0106132",
"name": "hcg",
"pos": [
98,
101
]
} |
the melanotic neuroectodermal tumor of infancy ( mnti ) is a rare , usually benign , pigmented neuroectodermal tumor which most often involves the maxilla . | NA | {
"id": "C0206094",
"name": "melanotic neuroectodermal tumor of infancy",
"pos": [
4,
46
]
} | {
"id": "C0206093",
"name": "neuroectodermal tumor",
"pos": [
95,
116
]
} |
differences in conditions of drug exposure , such as concurrent exposure to lectin or inclusion of protein , may alter the in vitro sensitivity of lymphocyte cfc to some drugs . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
76,
82
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
99,
106
]
} |
after 48 hr of treatment with 10 mm alpha-difluoromethylornithine , the putrescine and spermidine contents of both resistant and sensitive cells were less than 5 % of control levels , but the spermine level was slightly elevated . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
72,
82
]
} | {
"id": "C0037871",
"name": "contents",
"pos": [
98,
106
]
} |
after 48 hr of treatment with 10 mm alpha-difluoromethylornithine , the putrescine and spermidine contents of both resistant and sensitive cells were less than 5 % of control levels , but the spermine level was slightly elevated . | NA | {
"id": "C0037871",
"name": "contents",
"pos": [
98,
106
]
} | {
"id": "C0037874",
"name": "level",
"pos": [
201,
206
]
} |
dfmo given in the drinking water decreased spermidine levels , but dfmo treatment by any route did not alter the spermine levels of mouse epidermis . | NA | {
"id": "C0037871",
"name": "levels",
"pos": [
54,
60
]
} | {
"id": "C0037874",
"name": "levels",
"pos": [
122,
128
]
} |
isozyme profiles for 32 enzyme systems were studied in tumors induced by two strains of polyoma virus ( 2pta and lid1 ) , in two conventional mouse strains ( c3h/bida and nih ) , and in athymic ( nude ) mice of two genetic backgrounds ( c3h/hes nu/nu and nih nu/nu ) . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
0,
7
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
24,
30
]
} |
yac-1 lymphoma cells , both when cultured in vitro and when passaged in ascites form in vivo , synthesize gangliosides ( means of 22.1 and 14.7 nmol lipid-bound sialic acid isolated per 10 ( 8 ) cells , respectively ) with potent inhibitory effects on mitogen- and antigen-induced lymphoproliferation : 10 to 30 nmol hig... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
15,
20
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
506,
522
]
} |
monoclonal antibodies to carcinoembryonic antigen : ionic strength as a factor in the selection of antibodies for immunoscintigraphy . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
99,
109
]
} |
childhood cancers , most cutaneous t-cell and all non-t-cell leukemias and lymphomas , myeloid leukemias , hodgkin 's disease , and solid tumors were not associated with htlv . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
75,
84
]
} | {
"id": "C0019829",
"name": "hodgkin 's",
"pos": [
107,
117
]
} |
cloning and frequency analysis of haemopoietic stem cells producing cfc over weeks in long-term marrow cultures . | NA | {
"id": "C0018956",
"name": "haemopoietic stem cells",
"pos": [
34,
57
]
} | {
"id": "C0007634",
"name": "cfc",
"pos": [
68,
71
]
} |
using adherent marrow cell layers devoid of stem cells , in vitro cloning and the determination of the frequency of murine haemopoietic stem cells were performed by means of limiting dilution . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
22,
26
]
} | {
"id": "C0018956",
"name": "haemopoietic stem cells",
"pos": [
123,
146
]
} |
addition of as few as 2.5 x 10 ( 5 ) cultured ( anti-i-a + c treated to remove gamma-rcs ) cells causes significant inhibition of the responses of both syngeneic and allogeneic spleen cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
91,
96
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
166,
176
]
} |
a partial reversal of the ability of the phorbol ester tumor promoter 12-o-tetradecanoyl-phorbol-13-acetate to reduce egf binding to the class of high affinity receptors occurred following pre-exposure of cells to fa . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
41,
54
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol-13-acetate",
"pos": [
70,
107
]
} |
clear dose-dependence was observed in the effect of bbn on the potential , but of the doses of sodium saccharin used , only 5 % saccharin caused a significantly higher potential than in the control group . | NA | {
"id": "C0917900",
"name": "sodium saccharin",
"pos": [
95,
111
]
} | {
"id": "C0036023",
"name": "saccharin",
"pos": [
128,
137
]
} |
spermidine levels increased as the number of u.v.b exposures was increased and spermine levels tended to decrease . | NA | {
"id": "C0037871",
"name": "levels",
"pos": [
11,
17
]
} | {
"id": "C0037874",
"name": "levels",
"pos": [
88,
94
]
} |
chromosomal proteins from rat liver have been assessed immunologically for changes in specific cytokeratins or primary tumor nonhistone proteins during treatment with an azo dye hepatocarcinogen ( 3'-methyl-4-dimethylaminoazobenzene ) , ( 3'-me-dab ) or the hepatotoxin alpha-naphthyl-iso-thiocyanate ( alpha-nit ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
12,
20
]
} | {
"id": "C0027642",
"name": "tumor",
"pos": [
119,
124
]
} |
pretreatment of normal human fibroblasts and human colon carcinoma cells with mnng allows chloroethylnitrosourea to produce dna interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
29,
40
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
167,
172
]
} |
arterial baroreflex sensitivity , plasma norepinephrine ( ne ) and epinephrine ( e ) , and pressor and depressor responses were assessed in 25 patients with essential hypertension and 29 normotensive control subjects . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
41,
55
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
67,
78
]
} |
there was neither a reduction in the ability of the lower limb to extract epinephrine nor an increased norepinephrine outflow from the limb . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
74,
85
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
103,
117
]
} |
to determine the value of alternation of qrs morphology in determining the site of origin of sustained narrow qrs supraventricular tachycardia ( svt ) , we retrospectively studied 163 distinct tachycardias in 161 patients ( ages 4 to 91 years ) in whom the site of origin of svt was proven by intracardiac electrophysiol... | NA | {
"id": "C0039231",
"name": "tachycardias",
"pos": [
193,
205
]
} | {
"id": "C0039240",
"name": "svt",
"pos": [
275,
278
]
} |
we conclude that the presence of qrs alternation during sustained narrow qrs svt is highly indicative of a retrograde accessory av pathway in the tachycardia circuit . | NA | {
"id": "C0039240",
"name": "svt",
"pos": [
77,
80
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
146,
157
]
} |
we infused pge2 into 15 late-gestation newborn lambs to determine which factors regulate the ability of the ductus arteriosus to respond to pge . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
11,
15
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
140,
143
]
} |
in the case of aspat , the human enzymes of mitochondrial ( m-aspat ) and cytosolic ( s-aspat ) origin were purified to homogeneity from liver and erythrocytes respectively and used to prepare isoenzyme-specific anti-sera in rabbits . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
33,
40
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
193,
202
]
} |
among those enzymes measured by immunochemical techniques and which have found diagnostic application , mention will be made of alkaline phosphatase ( with particular reference to the intestinal , placental , and regan isoenzymes ) , lactate dehydrogenase ( in which renewed interest has developed due to techniques for ... | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
219,
228
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
588,
594
]
} |
the amount of dpc in amniotic fluid samples assessed by mass spectrometry was compared with results for total phosphatidylcholine quantified by thin-layer chromatography . | NA | {
"id": "C0000039",
"name": "dpc",
"pos": [
14,
17
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
110,
129
]
} |
basal and stimulated secretion of n-terminal pro-opiocortin ( pro-gamma-msh ) , acth and lph from seven pituitary and three ectopic acth secreting tumours have been studied in vitro using a perfused isolated cell system . | NA | {
"id": "C0033195",
"name": "pro-opiocortin",
"pos": [
45,
59
]
} | {
"id": "C0023832",
"name": "lph",
"pos": [
89,
92
]
} |
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