text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
somatostatin-28 and somatostatin-14 suppression of arginine- , insulin- , and trh-stimulated gh and prl secretion in man . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
0,
15
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
20,
35
]
} |
gh and prl responses to arginine infusion and to the combined pituitary stimulation test ( 0.1 u/kg of insulin , 200 micrograms of trh , 100 micrograms of lhrh ) were compared in five normal men during infusions of somatostatin-14 ( ss-14 ) and somatostatin-28 ( ss-28 ) , and during control infusions of vehicle alone . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
215,
230
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
245,
260
]
} |
arginine ( 0.5 g/kg ) infused from 30 to 60 min induced an increase in gh secretion in all subjects and this increase was completely abolished in these same subjects when infused with ss-14 and ss-28 . | NA | {
"id": "C0037659",
"name": "ss-14",
"pos": [
184,
189
]
} | {
"id": "C0074854",
"name": "ss-28",
"pos": [
194,
199
]
} |
arginine-induced hyperglycaemia was significantly greater during infusion of ss-14 and further enhanced by infusion of ss-28 . | NA | {
"id": "C0037659",
"name": "ss-14",
"pos": [
77,
82
]
} | {
"id": "C0074854",
"name": "ss-28",
"pos": [
119,
124
]
} |
the prl increase was significantly inhibited by ss-28 but not by ss-14 and this greater efficacy was also indicated by administering different doses of ss-28 to one subject . | NA | {
"id": "C0037659",
"name": "ss-14",
"pos": [
65,
70
]
} | {
"id": "C0074854",
"name": "ss-28",
"pos": [
152,
157
]
} |
an i.v . bolus injection of 10 mg of metoclopramide significantly increased the plasma prl , plasma aldosterone and 18-hydroxycorticosterone , but the plasma renin activity , plasma deoxycorticosterone , corticosterone and cortisol remained unchanged . | NA | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
116,
140
]
} | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
204,
218
]
} |
spleen cells and peripheral blood mononuclear cells ( pbmc ) from mice , which had recovered from infection with plasmodium chabaudi , were induced to produce anti-p. chabaudi antibody by incubating the cells with p. chabaudi parasitized red cells in marbrook cultures . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
17,
51
]
} | {
"id": "C0007634",
"name": "the cells",
"pos": [
199,
208
]
} |
spleen cells and pbmc from mice infected 2-4 months previously gave higher antibody titres in culture than similar cells from mice infected a year previously . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
17,
21
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
115,
120
]
} |
there was a good correlation between the ability of spleen cells or pbmc to be stimulated to produce antibody in vitro and the ability of mice similar to the cell donors to resist a challenge infection . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
68,
72
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
158,
162
]
} |
the lines were antigen specific ( i.e . responded to the allergen used to raise them and not to other antigens ) and required that the antigen was presented by autologous cells ( i.e . they were restricted ) . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
57,
65
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
135,
142
]
} |
these data identify ips as an agent for the study of aberrant immune regulation in autoimmune diseases and suggest that it may have potential therapeutic value in sle . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
83,
102
]
} | {
"id": "C0024141",
"name": "sle",
"pos": [
163,
166
]
} |
to elucidate the mechanism of hyporesponsiveness in the infected group rigorous adherent cell depletion , by adherence to plastic followed by a nylon wool column , was utilized . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
122,
129
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
144,
149
]
} |
expression of cfa/i , detected by agglutination of human erythrocytes was progressively lost during in vitro culture with antisera containing antibodies specific for cfa/i but , unlike k88 , cfa/i was re-expressed during further culture in the absence of antibody . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
122,
130
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
255,
263
]
} |
in contrast , only five to six per cent of sera from patients with other autoimmune diseases : lupus erythematosis or pernicious anaemia , had increased levels of anti-tubulin antibodies . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
73,
92
]
} | {
"id": "C0024141",
"name": "lupus erythematosis",
"pos": [
95,
114
]
} |
the serological abnormalities in rheumatoid vasculitis differed quantitatively as well as qualitatively from other ra patients . | NA | {
"id": "C0240903",
"name": "rheumatoid",
"pos": [
33,
43
]
} | {
"id": "C0003873",
"name": "ra",
"pos": [
115,
117
]
} |
surface staining of parietal cells was not abolished by absorption with dog or rat hepatocytes , dog or rat kidney cells , human fibroblasts or human ab red blood cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
29,
34
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
129,
140
]
} |
there is a consensus amongst clinical immunologists that an effort should be made to define , for non-specialists , criteria and indications for administering immunoglobulin ( gammaglobulin , immune serum globulin [ isg ] ) to patients . | NA | {
"id": "C0021027",
"name": "immunoglobulin",
"pos": [
159,
173
]
} | {
"id": "C0017007",
"name": "gammaglobulin",
"pos": [
176,
189
]
} |
in the absence of kininogen , activation of prekallikrein to kallikrein is grossly defective , which may in part account for the diminished response of the renin-angiotensin system to changes in sodium balance and posture . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
44,
57
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
61,
71
]
} |
the oxygen toxicity has a pulmonary and respiratory expression : clinical , histological and biochemical data show that death is related to the asphyxia generated by acute pulmonary edema . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
120,
125
]
} | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
144,
152
]
} |
fifty consecutive patients with severe chest trauma were studied prospectively to evaluate the frequency of significant cardiac injury and to determine what diagnostic studies were useful . | NA | {
"id": "C0039980",
"name": "chest trauma",
"pos": [
39,
51
]
} | {
"id": "C0018805",
"name": "of",
"pos": [
105,
107
]
} |
bowen 's disease is a squamous cell carcinoma characterized by isolated , grouped or confluent nodules , either flat , scaling , or crusted , with an arcuate or serpiginous configuration . | NA | {
"id": "C0006079",
"name": "bowen 's disease",
"pos": [
0,
16
]
} | {
"id": "C0007137",
"name": "squamous cell carcinoma",
"pos": [
22,
45
]
} |
fibroblasts from the patient showed the fragile x in 8 % to 12 % of cells , and fibroblasts from the normal individual showed no fragile x expression . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
68,
73
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
80,
91
]
} |
the current study asked : does regular antacid therapy have a favorable influence on the natural history of symptomatic reflux esophagitis , ie , does therapy heal or otherwise change esophagitis so that painful episodes are either less frequent , less severe , or both ? | NA | {
"id": "C0014869",
"name": "reflux esophagitis",
"pos": [
120,
138
]
} | {
"id": "C0014868",
"name": "esophagitis",
"pos": [
184,
195
]
} |
a significant increase in fraction free cloxacillin in maternal plasma occurred during pregnancy already from the 2nd trimester compared to the controls ( p less than 0.01 ) and was most pronounced at delivery ( median values 0.126 and 0.069 , respectively ) . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
87,
96
]
} | {
"id": "C0032980",
"name": "2nd",
"pos": [
114,
117
]
} |
however , because of potential side effects associated with retinoids , isotretinoin should be reserved for those patients who are unresponsive to conventional therapy , including topical and systemic antibiotics . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
60,
69
]
} | {
"id": "C0022265",
"name": "isotretinoin",
"pos": [
72,
84
]
} |
in men the order of frequency was : dichromate , phenyl-isopropyl-p-phenylene diamine , n-phenyl-cyclohexyl-p-phenylene diamine ( as concomitant allergy ? ) , cobalt ( as concomitant allergy ? ) , p-phenylene diamine , chloramphenicol , formaldehyde , phenylbutazone , balsam of peru , mercury amidochlorate , mercury bi... | NA | {
"id": "C0031468",
"name": "phenylene diamine",
"pos": [
68,
85
]
} | {
"id": "C0048678",
"name": "p-phenylene diamine",
"pos": [
197,
216
]
} |
autoantibodies against vasopressin ( avp ) -producing cells of the human pituitary gland as well as conventional antibodies were determined in 67 patients with central diabetes insipidus and in 141 controls without diabetes insipidus using an immunofluorescence technique . | NA | {
"id": "C0687720",
"name": "central diabetes insipidus",
"pos": [
160,
186
]
} | {
"id": "C0011848",
"name": "diabetes insipidus",
"pos": [
215,
233
]
} |
for this purpose there is a diphtheria toxoid of behringwerke for adults with only 5 iu toxoid/0.5 ml , which , however , after single application produced an antitoxic immunity ( greater than or equal to 0.1 iu/ml ) in previously sensitized subjects ( 17 of 49 ) . | NA | {
"id": "C0012551",
"name": "diphtheria toxoid",
"pos": [
28,
45
]
} | {
"id": "C0040555",
"name": "toxoid",
"pos": [
88,
94
]
} |
epinephrine ( e ) and norepinephrine ( ne ) released tsh over a 2-h period in a dose-dependent and stereospecific manner ( ed50 = 1 and 700 nm for the ( - ) and ( +/- ) stereoisomers of e ; 7 and 600 nm for the active and inactive stereoisomers of ne respectively ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
248,
250
]
} |
dihydroxyphenylalanine ( dopa ) and catecholamines ( ca ) concentrations were determined in plasma collected from chronically cannulated fetal and maternal sheep from days 125-140 of gestation . | NA | {
"id": "C0013023",
"name": "dihydroxyphenylalanine",
"pos": [
0,
22
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
36,
50
]
} |
dopamine ( da ) , norepinephrine , and epinephrine were determined simultaneously by the same radioenzymatic incubation procedure , followed by solvent extraction and two-dimensional thin layer chromatography . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
18,
32
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
39,
50
]
} |
the dopa level in the fetal circulation was 10-25 times higher than that of da , 5-10 times higher than that of norepinephrine , and 100 times higher than that of epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
112,
126
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
163,
174
]
} |
furthermore , dopa was the only ca that was significantly ( p less than 0.05 ) higher in fetal ( 3.5-4.5 ng/ml ) than in maternal plasma ( 1-1.5 ng/ml ) . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
14,
18
]
} | {
"id": "C0007412",
"name": "ca",
"pos": [
51,
53
]
} |
the effects of two intraventricular ( ivt ) 2-min pulses delivered 80 min apart of vehicle ( artificial cerebrospinal fluid ) , dopamine , norepinephrine , or epinephrine ( e ) on lh release were assessed . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
139,
153
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
159,
170
]
} |
in 3-4 days , a near-confluent monolayer of polygonal-shaped cells with less than 10 % fibroblasts was achieved . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
61,
66
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
87,
98
]
} |
the potency order of different adrenergic agonists was d , l-isoproterenol greater than l-norepinephrine greater than l-epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
90,
104
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
120,
131
]
} |
neuropeptides in the thyroid gland : distribution of substance p and gastrin/cholecystokinin and their effects on the secretion of iodothyronine and calcitonin . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
0,
13
]
} | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
149,
159
]
} |
when the nutrient medium ( minimum essential medium ) was supplemented with various hormones or free fatty acids , the long-chain fatty acids ( c14-c20 ) caused a decrease in the rate of 3h incorporation to a variable degree depending on the species of fatty acid . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
96,
112
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
253,
263
]
} |
sorbic acid and potassium sorbate are widely used generally recognized as safe ( gras ) food additives with an extremely high ( 25 mg/kg ) acceptable daily intake level . | NA | {
"id": "C0037686",
"name": "sorbic acid",
"pos": [
0,
11
]
} | {
"id": "C0032841",
"name": "potassium sorbate",
"pos": [
16,
33
]
} |
at the end of the bicycling test , plasma dopamine ( da ) , norepinephrine ( ne ) and epinephrine ( e ) concentrations increased similarly in both groups . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
60,
74
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
86,
97
]
} |
blood glutamine and blood alanine both show rises linearly related to power output during exercise , suggesting that if these amino acids are sinks for ammonia then the process of ammonia incorporation is saturated at high workloads . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
26,
33
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
126,
137
]
} |
twelve patients developed presumed non-a , non-b hepatitis ( five of these were hospitalized and three were jaundiced ) , and all 12 had received clotting factors from pooled plasma ( fibrinogen , factor viii , factor ix complex ) from different manufacturers . | NA | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
146,
162
]
} | {
"id": "C0015506",
"name": "factor viii",
"pos": [
197,
208
]
} |
twelve patients developed presumed non-a , non-b hepatitis ( five of these were hospitalized and three were jaundiced ) , and all 12 had received clotting factors from pooled plasma ( fibrinogen , factor viii , factor ix complex ) from different manufacturers . | NA | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
146,
162
]
} | {
"id": "C0015491",
"name": "factor ix complex",
"pos": [
211,
228
]
} |
it is acidic and contains three remarkably homologous repeating units of approximately 100 amino acids , each possessing a potential lipoyl binding site and a region that is characteristically rich in alanine and proline residues . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
91,
102
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
201,
208
]
} |
the rate of quenching of the fluorescence of pyridoxal 5'-phosphate in the active site of the beta 2 subunit of tryptophan synthase from escherichia coli was measured to estimate the accessibility of the coenzyme to the small molecules iodide and acrylamide . | NA | {
"id": "C0034266",
"name": "pyridoxal 5",
"pos": [
45,
56
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
204,
212
]
} |
as the alpha subunit binds to the beta 2 subunit , the tryptophan residue , which is within 2.2 nm of the active site of the beta 2 subunit , probably rotates with respect to the plane of the ring of the coenzyme , such that fluorescence energy transfer from tryptophan to pyridoxal phosphate is greatly reduced . | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
204,
212
]
} | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
273,
292
]
} |
electrophoretic analysis has established the presence of unique mitochondrial and cytosolic isoenzymes for many of the enzymes , e.g . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
92,
102
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
119,
126
]
} |
improvements in the isolation procedure and the analytical equipment enabled the detection of seven novel sialic acids in bovine submandibular gland glycoprotein : n-acetyl-8-o-acetylneuraminic acid , n-acetyl-8,9-di-o-acetylneuraminic acid , n-acetyl-7,8,9-tri-o-acetylneuraminic acid , n-glycoloyl-7-o-acetylneuraminic... | NA | {
"id": "C0037025",
"name": "sialic acids",
"pos": [
106,
118
]
} | {
"id": "C0067762",
"name": "n",
"pos": [
459,
460
]
} |
in addition , the sialic acids already known to occur in this tissue , namely n-acetylneuraminic acid , n-acetyl-7-o-acetylneuraminic acid , n-acetyl-9-o-acetylneuraminic acid , n-acetyl-7,9-di-o-acetylneuraminic acid , n-glycoloylneuraminic acid , and n-glycoloyl-9-o-acetylneuraminic acid could be identified . | NA | {
"id": "C0037025",
"name": "sialic",
"pos": [
18,
24
]
} | {
"id": "C0067762",
"name": "n",
"pos": [
303,
304
]
} |
the highest activities of both enzymes were found in freshly isolated chick-embryo tendon and cartilage cells , intermediate activities in confluent cultures of human skin and lung fibroblasts and mouse 3t6 fibroblasts , and the lowest values in three human sarcoma cell lines , the difference in protein disulphide isom... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
104,
109
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
430,
441
]
} |
a great similarity was also found between the changes in the two enzyme activities measured per cell during the growth of 3t6 fibroblast cultures from the early logarithmic phase to the stationary phase . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
96,
100
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
126,
136
]
} |
the data suggest that protein disulphide isomerase may be involved in the formation of intra-chain and inter-chain disulphide bonds in procollagens , but there is no collagen type-related variation in this enzyme activity of a magnitude that would explain the marked differences in the rates of formation of inter-chain ... | NA | {
"id": "C0033235",
"name": "procollagens",
"pos": [
135,
147
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
357,
365
]
} |
a double-blind , cross-over study was performed in 23 consecutive patients with unstable angina at rest in order to compare the efficacy of verapamil ( 480 mg/day ) and propranolol ( 240 mg/day ) in reducing the number of anginal crises and nitroglycerin ( ntg ) consumption . | NA | {
"id": "C0002965",
"name": "angina at rest",
"pos": [
89,
103
]
} | {
"id": "C0002962",
"name": "anginal",
"pos": [
222,
229
]
} |
the results of analysis of 99mtc-pyrophosphate ( 99mpyp ) , taken as a representative of the group of compounds having an organic p-o-p bond , and of the three diphosphonate compounds : methylene diphosphonate ( mdp ) , 2,3-dicarboxy propane diphosphonate ( dpd ) and ethane-1-hydroxy-1 , 1-diphosphonate ( ehdp ) , whic... | NA | {
"id": "C0066351",
"name": "methylene diphosphonate",
"pos": [
186,
209
]
} | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
291,
304
]
} |
the presence of the parent drug as a major component in rat plasma following intravenous administration and its absence after oral administration indicated that the elimination of bromocriptine proceeded almost entirely by metabolism in the liver . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
165,
176
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
223,
233
]
} |
in both species , dl 111-it was rapidly metabolized and excreted when given intravenously or subcutaneously in aqueous vehicles ( half-lives = 15-45 min . ) , whereas the kinetics were prolonged when it was administered in oily formulations ( half-lives = 7-10 h ) . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
171,
179
]
} | {
"id": "C0018517",
"name": "half-lives",
"pos": [
243,
253
]
} |
using lymph node cells from a patient with malignant melanoma of the cervical region , a consistent pattern of increased immunoglobulin binding to three human melanoma cell lines in contrast to a human colonic adenocarcinoma and a human skin-derived fibroblast line was demonstrated . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
17,
22
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
250,
260
]
} |
oral treatment with dfmo ( 2 % aqueous solution as sole drinking fluid , equivalent to 4 g dfmo/kg/day ) decreased markedly the odc activity and the putrescine and spermidine concentrations of the primary tumor , and stimulated s-adenosyl-l-methionine decarboxylase activity . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
149,
159
]
} | {
"id": "C0037871",
"name": "concentrations",
"pos": [
175,
189
]
} |
odc activity and putrescine and spermidine concentrations were similarly markedly reduced in the metastatic lung by dfmo treatment . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
17,
27
]
} | {
"id": "C0037871",
"name": "concentrations",
"pos": [
43,
57
]
} |
then , after 5 or 30 min , the subjects ingested , either activated charcoal suspension ( 50 g charcoal ) , syrup of ipecac , or , only after 5 min , water 300 ml . | NA | {
"id": "C0001275",
"name": "activated charcoal",
"pos": [
58,
76
]
} | {
"id": "C0007955",
"name": "charcoal",
"pos": [
95,
103
]
} |
however , the npbid of t and b cell preparations were indistinguishable by ( a ) the susceptibility of raid binding by the cells to inhibition by hapten or by antibodies to the variable regions of lambda light chains ( anti-v lambda ) and by ( b ) the ability of anti-v lambda and of monoclonal antibodies to the constan... | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
159,
169
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
284,
305
]
} |
eamg is an autoimmune disease induced by immunization with the purified acetylcholine receptor protein ( achr ) and is considered to be a good model for the human disease myasthenia gravis . | NA | {
"id": "C0752087",
"name": "eamg",
"pos": [
0,
4
]
} | {
"id": "C0026896",
"name": "disease myasthenia gravis",
"pos": [
163,
188
]
} |
phentolamine , which is considered a specific alpha-adrenoceptor antagonist , was tested for antagonist properties at presynaptic dopamine receptors and presynaptic alpha 2-adrenoceptors present on sympathetic nerve terminals in isolated right cat atria . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptor",
"pos": [
46,
64
]
} | {
"id": "C0001639",
"name": "alpha 2-adrenoceptors",
"pos": [
165,
186
]
} |
aminooxyacetic acid ( aoaa ) , baclofen , and tetrahydroisoxazolopyridineol ( thip ) ( gaba mimetics ) lengthened ethanol narcosis , while picrotoxin shortened ethanol narcosis . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
31,
39
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
87,
91
]
} |
the effects of cell ploidy on the biochemical characteristics of cultured cells were compared using human diploid vs tetraploid fibroblasts isolated with a non-selective method . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
128,
139
]
} |
we here studied the protein kinase activity and in vitro phosphorylable sites of non-histone nuclear proteins , 0.4 m nacl extracts ( mostly chromosomal proteins ) from chick embryo fibroblasts ( cef ) , infected or not with a schmidt ruppin strain subgroup a of rous sarcoma virus ( rsv ) . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
85,
92
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
93,
109
]
} |
we here studied the protein kinase activity and in vitro phosphorylable sites of non-histone nuclear proteins , 0.4 m nacl extracts ( mostly chromosomal proteins ) from chick embryo fibroblasts ( cef ) , infected or not with a schmidt ruppin strain subgroup a of rous sarcoma virus ( rsv ) . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
93,
109
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
153,
161
]
} |
in the lens epithelium on its capsule , preferential synthesis of alpha b2 vs alpha a2 crystallin subunits and synthesis of beta-crystallins ( mainly beta bp ) were observed . | NA | {
"id": "C0010422",
"name": "crystallin",
"pos": [
87,
97
]
} | {
"id": "C0005203",
"name": "beta-crystallins",
"pos": [
124,
140
]
} |
among these proteins , both mr 45 000 and mr 57 000 proteins are probably constituents of the water-soluble cytoskeletal proteins , respectively actin and vimentin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
12,
20
]
} | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
108,
129
]
} |
the process of cell-substratum adhesion of balb/c 3t3 fibroblasts on fibronectin ( fn ) -coated substrata was compared with that of cells adhering to substrata coated with the heparan sulfate ( hs ) -binding protein , platelet factor four ( pf4 ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
54,
65
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
132,
137
]
} |
within 2 h of spreading , cells on fn developed typical fibroblastic morphologies , whereas those on pf4 lacked polygonal orientations and formed numerous broadly spread lamellae . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
26,
31
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
56,
68
]
} |
and ( 3 ) monoclonal antibodies are valuable tools in 'mapping ' the orientation of cell surface molecules like fibronectin by measuring adhesive responses to antibody-coated substrata . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
10,
31
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
159,
167
]
} |
due to the effect of quartz , the lipid and phospholipid content of the lung significantly increases , the ratio of phospholipid fractions alters ; | NA | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
44,
56
]
} | {
"id": "C0771648",
"name": "of phospholipid fractions",
"pos": [
113,
138
]
} |
experiments on white rats were made to examine the action of sodium selenite alone and combined with tocopherol acetate ( vitamin e ) as well as that of a tincture prepared from the grass of the selenium-containing plant astragal on lipid peroxidation during liver poisoning with carbon tetrachloride and tetracycline co... | NA | {
"id": "C0078373",
"name": "tocopherol acetate",
"pos": [
101,
119
]
} | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
122,
131
]
} |
two-dimensional gel electrophoresis ( ief ) analysis of short-term [ 32p ] orthophosphate-labelled intermediate-sized filament proteins ( keratins and vimentin ) from transformed mitotic amnion cells ( ama ) , have shown that these proteins are modified coordinately and that the half life of the phosphate is about 13 m... | NA | {
"id": "C0021769",
"name": "intermediate",
"pos": [
99,
111
]
} | {
"id": "C0010803",
"name": "keratins",
"pos": [
331,
339
]
} |
two-dimensional gel electrophoresis ( ief ) analysis of short-term [ 32p ] orthophosphate-labelled intermediate-sized filament proteins ( keratins and vimentin ) from transformed mitotic amnion cells ( ama ) , have shown that these proteins are modified coordinately and that the half life of the phosphate is about 13 m... | NA | {
"id": "C0021769",
"name": "intermediate",
"pos": [
99,
111
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
355,
363
]
} |
the introduction of the cordycepin analog of ( 2'-5 ' ) an , ( 2'-5 ' ) ppp ( 3'dap ) n3'da [ referred to as ( 2'-5 ' ) p33'dan ] , into mouse l929 cells and cultured human fibroblasts resulted in a dose-dependent inhibition of protein synthesis which was comparable to the inhibition observed by ( 2'-5 ' ) ppp ( ap ) n... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
148,
153
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
173,
184
]
} |
the results strongly indicate that the pre-penicillinase is processed by the globomycin-sensitive signal peptidase in e. coli , and the modification of precursor by lipid precedes removal of the signal peptide as it does with the membrane lipoproteins of e. coli . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
165,
170
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
239,
251
]
} |
this method was used to monitor the activity of plasminogen activator synthetized by fibroblastic cells ( bhk 21 c 13 ) either released in the supernatants or cell-associated . | NA | {
"id": "C0016030",
"name": "fibroblastic cells",
"pos": [
85,
103
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
159,
163
]
} |
gtp and its hydrolysis-resistant analogue , guanylylimidodiphosphate ( gppnhp ) , display a half-maximal stimulating effect at almost the same concentration ( 5 x 10 ( -6 ) m ) . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
0,
3
]
} | {
"id": "C0018366",
"name": "guanylylimidodiphosphate",
"pos": [
44,
68
]
} |
the effect of the deaminase is abolished by addition of the adenosine analogue , n6-phenylisopropyladenosine which is not metabolised by the deaminase . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
60,
69
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
84,
108
]
} |
all of these monoclonal antibodies to have the same basic specificity as shown by competition for binding to the main immunogenic region on the receptor , but these antibodies differ in fine specificity as shown by reaction with denatured receptor subunits and interspecies cross-reaction . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
13,
34
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
165,
175
]
} |
treatment of cyc- cells with islet-activating protein ( iap ) , which causes adp-ribosylation of an mr 40 000 polypeptide in cyc- membranes , abolishes adenylate cyclase inhibition by gtp and the peptide hormone , somatostatin , but not that induced by gtp gamma s . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
184,
187
]
} | {
"id": "C0079469",
"name": "induced",
"pos": [
242,
249
]
} |
dopamine , epinephrine , norepinephrine and serotonin all inhibit reserpine binding at concentrations similar to those required for inhibition of dopamine uptake . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
11,
22
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
25,
39
]
} |
the effect of various anions in destabilizing yeast nucleoprotein complexes followed the order f- less than cl- less than br- less than clo-4 congruent to cl3ccoo- . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
22,
28
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
95,
96
]
} |
although our knowledge of the initial steps in the transduction of hypertrophic stimuli to increased rna and protein synthesis is scanty , progress is being made in elucidating the control of nuclear rna synthesis in the normal and hypertrophied myocardium . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
101,
104
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
192,
203
]
} |
keratinocyte cell line cells produce increased levels of etaf activity after exposure to a variety of cell-damaging agents such as silica , endotoxin , phorbol myristate acetate , hydroxyurea , and mechanical disruption . | NA | {
"id": "C0022567",
"name": "cell",
"pos": [
13,
17
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
102,
106
]
} |
although clomiphene citrate is likely to remain the most common drug prescribed to anovulatory women , treatment programs with clomiphene have recently been modified with much improved success rates resulting . | NA | {
"id": "C0546859",
"name": "clomiphene citrate",
"pos": [
9,
27
]
} | {
"id": "C0009008",
"name": "clomiphene",
"pos": [
127,
137
]
} |
these values are very different from those of beta-d-galactosidase activity . beta-d-fucosides and beta-d-glucosides completely compete for a common active site in mixed-substrate experiments , while beta-d-galactosides only partially compete with both glycosides . | NA | {
"id": "C0017765",
"name": "glucosides",
"pos": [
106,
116
]
} | {
"id": "C0017977",
"name": "glycosides",
"pos": [
253,
263
]
} |
these values are very different from those of beta-d-galactosidase activity . beta-d-fucosides and beta-d-glucosides completely compete for a common active site in mixed-substrate experiments , while beta-d-galactosides only partially compete with both glycosides . | NA | {
"id": "C0016956",
"name": "galactosides",
"pos": [
207,
219
]
} | {
"id": "C0017977",
"name": "glycosides",
"pos": [
253,
263
]
} |
the occurrence of lysozyme , neuraminidase and fourteen other glycosidases was investigated in the three lymphoma cell lines namalva , raji and daudi derived from a burkitt 's lymphoma and the lymphoblastoid cell line robinson from epstein-barr virus transformed normal peripheral blood lymphocytes . | NA | {
"id": "C0026794",
"name": "lysozyme",
"pos": [
18,
26
]
} | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
62,
74
]
} |
the occurrence of lysozyme , neuraminidase and fourteen other glycosidases was investigated in the three lymphoma cell lines namalva , raji and daudi derived from a burkitt 's lymphoma and the lymphoblastoid cell line robinson from epstein-barr virus transformed normal peripheral blood lymphocytes . | NA | {
"id": "C0027803",
"name": "neuraminidase",
"pos": [
29,
42
]
} | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
62,
74
]
} |
the effectiveness of gluconeogenic precursors in hepatocytes isolated from 18 day old chick embryos is : lactate much much greater than pyruvate greater than alanine = glutamine greater than glycerol and other amino acids . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
158,
165
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
210,
221
]
} |
male hepatocytes metabolized estradiol-17 beta , 17 alpha-ethinylestradiol and mestranol extremely rapidly ( t 1/2 = 40 , 60 and 300 min , respectively ) , whereas these were more stable in cultures of female hepatocytes ( t 1/2 = 120 , 150 and 640 min , respectively ) . | NA | {
"id": "C0015011",
"name": "ethinylestradiol",
"pos": [
58,
74
]
} | {
"id": "C0025506",
"name": "mestranol",
"pos": [
79,
88
]
} |
the level and rate of accumulation of vitellogenin mrna were 5-15 times higher in female than in male hepatocytes , mestranol and estradiol being more potent than 17 alpha-ethinylestradiol and diethylstilbestrol . | NA | {
"id": "C0025506",
"name": "mestranol",
"pos": [
116,
125
]
} | {
"id": "C0015011",
"name": "ethinylestradiol",
"pos": [
172,
188
]
} |
the expression and core protein structure of two proteoglycans , the major cartilage proteoglycan isolated from a rat chondrosarcoma and a small molecular weight chondroitin sulfate proteoglycan isolated from a rat yolk sac tumor , have been compared . | NA | {
"id": "C0033692",
"name": "proteoglycan",
"pos": [
49,
61
]
} | {
"id": "C0033689",
"name": "chondroitin sulfate proteoglycan",
"pos": [
162,
194
]
} |
these results indicate that the proteoglycan isolated from the yolk sac tumor is similar to the small chondroitin sulfate proteoglycan species found in cartilage and support the existence of at least two dissimilar and genetically independent chondroitin sulfate proteoglycan core proteins . | NA | {
"id": "C0033692",
"name": "proteoglycan",
"pos": [
32,
44
]
} | {
"id": "C0033689",
"name": "chondroitin sulfate proteoglycan",
"pos": [
243,
275
]
} |
the high mobility group or hmg proteins are nonhistone chromosomal proteins that have been found in relatively high amounts in nuclei of many tissues . | NA | {
"id": "C0019534",
"name": "hmg proteins",
"pos": [
27,
39
]
} | {
"id": "C0008600",
"name": "nonhistone chromosomal proteins",
"pos": [
44,
75
]
} |
both antagonists cause a significant delay of the cell division which , however , can be prevented by the addition of either 5-hydroxytryptophane , serotonin , or 5-methoxytryptamine . | NA | {
"id": "C0036751",
"name": "serotonin",
"pos": [
148,
157
]
} | {
"id": "C0000589",
"name": "5-methoxytryptamine",
"pos": [
163,
182
]
} |
therefore , it appears that the hyperinsulinemia seen in obese individuals may not be a simple function of insulin resistance , and that ability of insulin to stimulate glucose utilization is not significantly impaired in moderately obese subjects with normal glucose tolerance . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
32,
48
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
107,
125
]
} |
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