text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
paired comparisons of the glycaemic response to the five legumes with those of the seven other starchy foods ( breads , spaghetti , rice , cornflakes , oatmeal porridge and potatoes ) showed that the mean peak rise in blood glucose concentration and mean area under the glucose curve after beans were 23 and 28 % lower ,... | NA | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
215,
231
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
270,
277
]
} |
in sham-operated rats , intravenous administration of 14c-very low density lipoprotein triglycerides ( with labelled esterified fatty acids ) caused an initial decrease and subsequent increase in plasma 14c-lipids of both very low density lipoproteins ( vldl ) ( density less than 1.006 ) and lipoproteins of density gre... | NA | {
"id": "C0023825",
"name": "very low",
"pos": [
58,
66
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
293,
305
]
} |
insulin treatment in sham-operated animals decreased circulating 14c-lipids in vldl and in lipoproteins of density greater than 1.019 , while intermediate density ( 1.006-1.019 ) lipoproteins increased . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
69,
75
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
179,
191
]
} |
insulin treatment in sham-operated animals decreased circulating 14c-lipids in vldl and in lipoproteins of density greater than 1.019 , while intermediate density ( 1.006-1.019 ) lipoproteins increased . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
79,
83
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
179,
191
]
} |
insulin treatment in these rats enhanced the disappearance from circulation of 14c-vldl and of lipoproteins of density greater than 1.019 , as well as the appearance of 14c-intermediate density lipoproteins . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
83,
87
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
194,
206
]
} |
antitumor antibody was another mediator that induced tumor lysis in cooperation with pmns ( antibody-dependent pmn-mediated cytolysis ) . | NA | {
"id": "C0003251",
"name": "antitumor",
"pos": [
0,
9
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
92,
100
]
} |
a variety of liver diseases including chronic hepatitis and cirrhosis were seen in the livers of a majority of the ducks from chi-tung . | NA | {
"id": "C0023895",
"name": "of liver diseases",
"pos": [
10,
27
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
60,
69
]
} |
aromatic amino acids and tryptophan increased more in cirrhotics as a result of their decreased liver function . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
0,
20
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
25,
35
]
} |
branched-chain amino acid response to protein ingestion significantly correlated with blood glucose response to oral glucose ( r = 0.714 ) , and with insulin resistance during the glucose tolerance test , when assessed by the insulinogenic index ( r = 0.628 ) . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
86,
99
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
180,
187
]
} |
twenty days following the administration of the hormone the newly-formed mass of fibroblast-like cells penetrated the underlying cartilage , split it and formed a direct communication with the marrow cavity . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
22,
25
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
81,
91
]
} |
hence , it seems very possible that if a corticosteroid hormone is administered to newborn animals it possesses the capacity to affect the normal differentiative pathway of pre-chondroblasts and shift their developmental pathway toward the fibroblastic cell line . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
41,
55
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
56,
63
]
} |
to further evaluate thyroid function in patients with liver disease , we have measured total and free t3 and t4 , thyroxine binding globulin , basal and thyrotropin releasing hormone-stimulated thyrotropin and thyroglobulin antibodies in 33 patients with liver cirrhosis , in 22 with chronic hepatitis and in 30 healthy ... | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
54,
67
]
} | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
255,
270
]
} |
simultaneous administration of 50 mg sodium ascorbate ( vitamin c ) /kg body weight inhibited the nitrosation by about 80 % while 50 mg alpha-tocopherol acetate ( vitamin e ) /kg body weight reduced the nitrosation by about a half . | NA | {
"id": "C0887557",
"name": "sodium ascorbate",
"pos": [
37,
53
]
} | {
"id": "C0003968",
"name": "vitamin c",
"pos": [
56,
65
]
} |
simultaneous administration of 50 mg sodium ascorbate ( vitamin c ) /kg body weight inhibited the nitrosation by about 80 % while 50 mg alpha-tocopherol acetate ( vitamin e ) /kg body weight reduced the nitrosation by about a half . | NA | {
"id": "C1999896",
"name": "alpha-tocopherol acetate",
"pos": [
136,
160
]
} | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
163,
172
]
} |
fasting blood glucose , fasting insulin , sum of blood glucose and glucose elimination rate during an intravenous glucose tolerance test remained normal in the duct-ligated and ethibloc-occluded animals . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
8,
21
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
114,
121
]
} |
ornithine , an amino acid not incorporated into protein and produced from arginine in the urea cycle , is an albumin-stimulating amino acid and is the precursor of the polyamines , and we have shown that the polyamine spermine promotes bound polysome aggregation . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
48,
55
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
109,
116
]
} |
to test the concept that ureogenesis with its generation of ornithine might play a key role in albumin synthesis regulation via the polyamine pathway , isolated livers from fasted donors were perfused with ornithine , alpha-difluoromethyl ornithine ( dfmo ) , and spermine . | NA | {
"id": "C0029277",
"name": "ornithine",
"pos": [
60,
69
]
} | {
"id": "C0002260",
"name": "alpha-difluoromethyl",
"pos": [
218,
238
]
} |
it can be further deduced that the earliest ancestral ctt haemoglobins were monomers and that a branch to all extant dimeric ctt haemoglobins emerged later in phylogeny near the base of chironomidae , but perhaps still before chironomus itself evolved . | NA | {
"id": "C0019046",
"name": "haemoglobins",
"pos": [
58,
70
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
209,
210
]
} |
5 ) comparative studies with a variety of carbohydrates indicated that isolation media based on disaccharides are inferior to those based on monosaccharides in the preparation of functionally intact mitochondria from rat liver . | NA | {
"id": "C0007004",
"name": "carbohydrates",
"pos": [
42,
55
]
} | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
141,
156
]
} |
the amino-acid composition was determined and isoleucine and alanine were identified as the only n-terminal amino-acid residues . | NA | {
"id": "C0002520",
"name": "amino-acid",
"pos": [
4,
14
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
61,
68
]
} |
the author differentiates between two major types of the disorder , the generalized and partial epilepsies , and describes different kinds of seizures in epileptic patients . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
142,
150
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
154,
163
]
} |
1 two cases of drug-induced rhabdomyolysis , one of them presenting with acute myoglobinuric renal failure are described . | NA | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
28,
42
]
} | {
"id": "C0027080",
"name": "myoglobinuric",
"pos": [
79,
92
]
} |
1 the complexing agents in established clinical use are the polyaminopolycarboxylic acid edta ( ethylenediamine tetraacetate ) and the thiols bal ( 2 , 3-dimercaptopropanol ) and d-penicillamine . | NA | {
"id": "C0038734",
"name": "thiols",
"pos": [
135,
141
]
} | {
"id": "C0012383",
"name": "dimercaptopropanol",
"pos": [
154,
172
]
} |
liposomes containing l2c antigens were as antigenic as intact tumour cells in the elicitation of delayed-type hypersensitivity responses in strain-2 guinea-pigs previously immunized against l2c tumours . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
25,
33
]
} | {
"id": "C0003335",
"name": "antigenic",
"pos": [
42,
51
]
} |
the systemic secretion of a serine protease , rat mast-cell protease ii ( rmcpii ) , a major product of rat mucosal mast cells ( mmc ) , was measured by a sensitive enzyme-linked immunosorbent assay ( elisa ) in the sera of naive and primed rats challenged with the nematode n. brasiliensis . | NA | {
"id": "C0036734",
"name": "serine protease",
"pos": [
28,
43
]
} | {
"id": "C0147080",
"name": "mast-cell protease ii",
"pos": [
50,
71
]
} |
binding of soluble r-igg anti-bovine serum albumin ( bsa ) ic , prepared at molar antigen : antibody ( ag : ab ) ratio of 2:1 and 12:1 , showed quite different behaviour , the ic binding with association constants almost 10-fold lower than the affinity of monomeric r-igg , but binding six- to seven-fold as many igg mol... | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
92,
100
]
} | {
"id": "C0003313",
"name": "ic",
"pos": [
263,
265
]
} |
various amounts of thyroglobulin ( 5-500 micrograms ) were used to immunize low ( dba/2 and c57bl/6 ) and high ( akr ) responder mice to observe the possible role of different thyroglobulin epitopes ( or of their density ) on the development of thyroiditis , to determine whether the h-2 control is observed for various ... | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
190,
198
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
331,
338
]
} |
( 4 ) analysis of antigen antibody complexes by size-exclusion high pressure liquid chromatography showed bw6 and b7 antibodies could form tetramolecular complexes with papain-solubilized hla-b7 . | NA | {
"id": "C0003313",
"name": "antigen antibody complexes",
"pos": [
18,
44
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
117,
127
]
} |
supine plasma concentration of norepinephrine ( pne ) , epinephrine ( pe ) , and aldosterone ( pa ) , plasma renin activity ( pra ) , and blood volume ( bv ) were measured in 25 normotensive and 11 hypertensive patients with biopsy-proven glomerulonephritis who had serum creatinine concentrations of less than 1.6 mg/dl... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
31,
45
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
56,
67
]
} |
kinetics were linear between 20 and 60 mg , and the half-life of nifedipine tablets was close to 10 hours . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
0,
8
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
52,
61
]
} |
to elucidate the mechanisms involved in calcium-mediated blood pressure ( bp ) control , plasma norepinephrine ( ne ) , epinephrine , renin activity , and angiotensin ii ( aii ) levels and the cardiovascular pressor responsiveness to ne and aii were assessed before and during acute mild hypercalcemia or short-term calc... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
99,
110
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
388,
390
]
} |
in normal subjects , systolic bp and plasma ne and epinephrine concentrations were increased significantly ( p less than 0.05 ) during an acute rise in serum ca of 3.1 mg/dl ( intermediate rate ca infusion , 0.05 mg/kg/min for 3 hours ) , but not following an increase of 1 mg/dl ( low rate ca infusion , 0.034 mg/kg/min... | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
44,
46
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
51,
62
]
} |
cholesterol and ldl-cholesterol fell significantly ( p less than 0.001 ) to `` '' supranormal '' '' values , hdl-cholesterol and triglycerides remained almost constant . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
0,
11
]
} | {
"id": "C0023824",
"name": "ldl-cholesterol",
"pos": [
16,
31
]
} |
cholesterol and ldl-cholesterol fell significantly ( p less than 0.001 ) to `` '' supranormal '' '' values , hdl-cholesterol and triglycerides remained almost constant . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
0,
11
]
} | {
"id": "C0023822",
"name": ", hdl-cholester",
"pos": [
107,
122
]
} |
at a protein concentration of 2 micrograms/ml , m. hyopneumoniae membranes , prepared from freeze-thaw lysed cells , were capable of inducing cytopathic effect in mrc-5 fibroblasts within 24 h . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
109,
114
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
169,
180
]
} |
in addition , the sulfhydryl ( thiol ) compounds cysteamine , cysteine , and acetylcysteine strikingly reduced the secretory response and the guanylate cyclase response to st . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
62,
70
]
} | {
"id": "C0001047",
"name": "acetylcysteine",
"pos": [
77,
91
]
} |
the results indicate that the detoxification is probably due to multiple effects of the ionizing radiation on bacterial lipopolysaccharides , and the action involves ( i ) the destruction of polysaccharide moieties and possibly ( ii ) the alteration of lipid a component of the endotoxin molecule . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
120,
139
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
253,
260
]
} |
the results indicate that the detoxification is probably due to multiple effects of the ionizing radiation on bacterial lipopolysaccharides , and the action involves ( i ) the destruction of polysaccharide moieties and possibly ( ii ) the alteration of lipid a component of the endotoxin molecule . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
120,
139
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
278,
287
]
} |
the cold agglutinin antibodies in group b type iii and s. pneumoniae type xiv antiserum reacted with erythrocytes at higher temperatures ( up to 31 degrees c ) than did group c antibodies ( up to 14 degrees c ) . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
78,
87
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
177,
187
]
} |
measurements of the incorporation of glucose from glucosyl-labeled sucrose into glucan by cell-associated glucosyltransferase enzyme activity and the thermal labilities of catalytic and receptor functions , as well as the binding of labeled dextrans to the cells , provide evidence that neither dextranase nor glucosyltr... | NA | {
"id": "C0011806",
"name": "dextrans",
"pos": [
241,
249
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
358,
365
]
} |
e. coli j5 is a udp-galactose-4-epimerase-deficient mutant of e. coli 0111b4 , and its lps , therefore , contains mainly lipid a , as it lacks the polysaccharide side chains . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
87,
90
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
121,
128
]
} |
when lipid a and the polysaccharide fraction were isolated from 0111b4 lps , it was shown that lipid a had the same deleterious effect on pmn function as did j5 lps and that the lps fraction had no effect . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
5,
12
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
178,
181
]
} |
we hypothesize that the lipid a portion of lps is toxic for pmn due to the induction of toxic oxygen species by the pmn . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
24,
31
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
43,
46
]
} |
purified p. aeruginosa pyocyanine , a low-molecular-weight phenazine pigment present in culture supernatant , was strongly inhibitory for lymphocyte proliferation . | NA | {
"id": "C0034211",
"name": "pyocyanine",
"pos": [
23,
33
]
} | {
"id": "C0031375",
"name": "phenazine",
"pos": [
59,
68
]
} |
extraction of pyocyanine and phenazine pigments from inhibitory p. aeruginosa supernatants eliminated their inhibitory activity . | NA | {
"id": "C0034211",
"name": "pyocyanine",
"pos": [
14,
24
]
} | {
"id": "C0031375",
"name": "phenazine",
"pos": [
29,
38
]
} |
inhibitors were recovered from reverse-phase chromatographic cartridges by both chloroform and methanol elution , indicating that pyocyanine and other phenazine pigments present in p. aeruginosa supernatants are responsible for the inhibition of lymphocyte proliferation . | NA | {
"id": "C0034211",
"name": "pyocyanine",
"pos": [
130,
140
]
} | {
"id": "C0031375",
"name": "phenazine",
"pos": [
151,
160
]
} |
immunoglobulin m ( igm ) appeared to be the major class of antibody responsible for the c. albicans-agglutinating activity of the immune sera . | NA | {
"id": "C0020861",
"name": "immunoglobulin m",
"pos": [
0,
16
]
} | {
"id": "C0021017",
"name": "class",
"pos": [
50,
55
]
} |
the new enterotoxin was still produced by the cured strain , demonstrating that the gene ( s ) encoding the toxin was not located on prb1 or prb2 and was most likely on the bacterial chromosome . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
8,
19
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
108,
113
]
} |
in mice inoculated intracerebrally , virus antigen was present mainly in choroid plexus , hippocampal nuclei , and meninges , but in mice inoculated intraperitoneally , central nervous system infection was marked by antigen accumulation in cortical nuclei and thalamus . | NA | {
"id": "C0003342",
"name": "virus antigen",
"pos": [
37,
50
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
216,
223
]
} |
the proportion of mrha strains was significantly higher in patients with symptomatic uti ( 75 % ) than in women with non-significant bacteriuria ( 30 % , p less than 0.001 ) , pregnant women with asymptomatic uti ( 34 % , p less than 0.0001 ) and healthy controls ( 0 % ) . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
133,
144
]
} | {
"id": "C0042029",
"name": "uti",
"pos": [
209,
212
]
} |
the proportion of msha strains was significantly lower in patients with symptomatic uti ( 22 % ) than in women with non-significant bacteriuria ( 46 % , p less than 0.001 ) and pregnant women with asymptomatic uti ( 52 % , p less than 0.01 ) . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
132,
143
]
} | {
"id": "C0042029",
"name": "uti",
"pos": [
210,
213
]
} |
in vitro effects of the retinoids 13-cis-retinoic acid ( ro4-3780 ) and etretinate ( ro 10-9359 ) on dna synthesis and the fine structure of different guinea pig and human lymphoid cells were tested . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
24,
33
]
} | {
"id": "C0022265",
"name": "13-cis-retinoic acid",
"pos": [
34,
54
]
} |
the lai response of peripheral blood mnc was examined after the subcutaneous isografting of 1 x 10 ( 7 ) x-irradiated dmh-w49 colon carcinoma cells . | NA | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
20,
36
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
142,
147
]
} |
peripheral blood mononuclear cells ( mnc ) of rats , which had received a subcutaneous inoculation of either viable or x-irradiated syngeneic dmh-w49 colon carcinoma cells , were investigated sequentially for sensitization against tumor-associated antigens by a new micro-glass-tube leukocyte adherence inhibition ( lai ... | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
0,
34
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
166,
171
]
} |
the expression of thy-1 was examined on fresh frozen sections of melanoma and control skin lesions using a monoclonal antibody to thy-1 and immunoperoxidase-labelled second antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
107,
126
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
173,
183
]
} |
in the 1 h drug exposure experiments six drugs , doxorubicin ( dx ) , 4'-deoxydoxorubicin ( deodx ) , 4'epidoxorubicin ( epidx ) , 4'-o-methyldoxorubicin ( o-dx ) , n-trifluoroacetyldoxorubicin-14-valerate ( ad-32 ) and 5-fluorouracil ( fura ) were studied , while in continuous drug exposure experiments four of the abo... | NA | {
"id": "C0014582",
"name": "4'epidoxorubicin",
"pos": [
102,
118
]
} | {
"id": "C0013089",
"name": "dx",
"pos": [
354,
356
]
} |
the results obtained demonstrate that this new antitumor anthracycline develops a lower acute cardiotoxic effect and suggest that 4'-epi-doxorubicin is endowed with a reduced chronic cardiotoxicity as compared to doxorubicin . | NA | {
"id": "C0014582",
"name": "4",
"pos": [
130,
131
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
213,
224
]
} |
the possible effects of conalbumin ( a glycoprotein closely resembling lactoferrin ) on iron transport across the brush border of intestinal cells of the rat were evaluated in vitro . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
39,
51
]
} | {
"id": "C0022942",
"name": "lactoferrin",
"pos": [
71,
82
]
} |
conalbumin , a glycoprotein derived from eggwhite , has the property , like lactoferrin , of binding iron ions . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
15,
27
]
} | {
"id": "C0022942",
"name": "lactoferrin",
"pos": [
76,
87
]
} |
in order to clarify the pathophysiological significance of the fibrinogen ( fgdp ) -protamine complex , the interaction between fibrinogen and protamine sulphate was studied in vitro and in vivo . | NA | {
"id": "C0033603",
"name": "protamine",
"pos": [
84,
93
]
} | {
"id": "C0033602",
"name": "protamine",
"pos": [
143,
152
]
} |
an increased incidence in nafcillin ( semisynthetic penicillins ) resistant staphylococcus aureus ( sr-sa ) , which peaked in january 1980 , was noted in columbus children 's hospital ( cch ) , columbus , ohio . | NA | {
"id": "C0027324",
"name": "nafcillin",
"pos": [
26,
35
]
} | {
"id": "C0030842",
"name": "penicillins",
"pos": [
52,
63
]
} |
in this study , the glycosaminoglycans present in bruch 's membrane were identified and found to be heparan sulfate with small amounts of chondroitin and/or dermatan sulfate and hyaluronic acid . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
20,
38
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
100,
115
]
} |
in this study , the glycosaminoglycans present in bruch 's membrane were identified and found to be heparan sulfate with small amounts of chondroitin and/or dermatan sulfate and hyaluronic acid . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
20,
38
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
138,
149
]
} |
in this study , the glycosaminoglycans present in bruch 's membrane were identified and found to be heparan sulfate with small amounts of chondroitin and/or dermatan sulfate and hyaluronic acid . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
138,
149
]
} | {
"id": "C0011602",
"name": "dermatan sulfate",
"pos": [
157,
173
]
} |
the y79 cells , which characteristically grow as a suspension culture , were found to attach directly to the fibroblasts and pigment epithelium on the flask surface . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
8,
13
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
109,
120
]
} |
in summary , both fibroblast and pigment epithelium functioned as an effective carrier cell layer for retinoblastoma cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
18,
28
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
117,
122
]
} |
these results were taken as evidence that the two functional subunits of the hsv-tk enzyme complex , amp : dthd ( deoxythymidine ) phosphotransferase and atp : dthd kinase , catalyze highly reversible enzyme reactions . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
84,
98
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
201,
207
]
} |
sixty-one previously reported cases of systemic bacillus infections are reviewed according to type of infection ( endocarditis , meningitis or pulmonary infection ) , and the underlying conditions , ways of acquiring the infection , clinical picture and mortality are discussed . | NA | {
"id": "C0243026",
"name": "systemic",
"pos": [
39,
47
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
221,
230
]
} |
the combination of aromatic retinoid with methotrexate was successfully used in the treatment of two patients with a particularly severe course of psoriasis , one having psoriatic erythroderma coupled with psoriatic arthritis and the other psoriatic erythroderma . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
147,
156
]
} | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
206,
225
]
} |
among them will be the realization of the biochemical and consequent biological differences between plutonium and radium , the first demonstration of carcinogenicity of the actinides , their behavior in bone , their relative toxicity , carcinogenesis after inhalation , the genesis of the `` '' king-size '' '' experimen... | NA | {
"id": "C0032259",
"name": "plutonium",
"pos": [
100,
109
]
} | {
"id": "C0025553",
"name": "actinides",
"pos": [
173,
182
]
} |
these factors include the chemical form ( s ) and solubility of plutonium in natural waters , its behavior in relation to natural processes ( geochemical and biological ) , its fate in water treatment systems , and its uptake by man from drinking water . | NA | {
"id": "C0043047",
"name": "waters",
"pos": [
85,
91
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
238,
252
]
} |
in groups of four , men and women in their 40s and 50s , some of them lean and some overweight , overate for 30 d by 1000 kcal/d ( 4186 kj/d ) more than they needed to maintain weight . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
84,
94
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
177,
183
]
} |
unoxidized insulin and proinsulin suspended by electrophoresis in polyacrylamide gels were fixed with bouin 's fluid and placed in aldehyde fuchsin for one hour . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
11,
18
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
23,
33
]
} |
because the unoxidized proteins were not stained by aldehyde fuchsin , it was concluded that neither insulin or proinsulin are responsible for the intense aldehyde fuchsin staining of unoxidized pancreatic b cell granules in tissue sections . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
101,
108
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
112,
122
]
} |
a series of controlled experiments was undertaken to test the effects of fixatives , oxidation and destaining procedures on aldehyde fuchsin staining of insulin , proinsulin and other proteins immobilized in polyacrylamide gels . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
153,
160
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
163,
173
]
} |
it was concluded that neither insulin nor proinsulin is likely to be responsible for the intense aldehyde fuchsin staining of unoxidized pancreatic b cell granules in tissue sections . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
30,
37
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
42,
52
]
} |
instead , our results suggest that viruses pick up mhc antigens from the host cell membrane according to the concentration of those antigens on the surface of the cells at the time of virus budding . | NA | {
"id": "C0003342",
"name": "viruses",
"pos": [
35,
42
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
132,
140
]
} |
human cord blood mononuclear cells from single donors were separated on minicolumns of peanut agglutinin ( pna ) coupled to sepharose beads to yield two fractions : unbound cells ( pna- , 78 % ) that were eluted with phosphate buffered saline , and bound cells ( pna+ , 22 % ) eluted with 0.2 m d-galactose . | NA | {
"id": "C1321301",
"name": "blood mononuclear cells",
"pos": [
11,
34
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
255,
260
]
} |
of 27 patients with carcinoma , 21 had squamous cell carcinoma , 4 had basal cell carcinoma and 2 had adenoid cystic carcinoma . | NA | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
20,
29
]
} | {
"id": "C0007117",
"name": "basal cell carcinoma",
"pos": [
71,
91
]
} |
there was a significant decrease in carotid body content of dopamine ( da ) , norepinephrine ( ne ) , and epinephrine ( e ) 1 h after ampt administration . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
78,
92
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
106,
117
]
} |
fifteen dogs with idiopathic epilepsy were included in a 9-month clinical trial to determine the therapeutic serum concentrations of primidone and its active metabolites , phenobarbital and phenylethylmalonamide . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
133,
142
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
172,
185
]
} |
serum phenobarbital was the best metabolite of primidone to use to assess therapeutic serum concentrations . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
6,
19
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
47,
56
]
} |
the final products of the catabolism of arginine that can be utilized as nitrogen sources by neurospora crassa are ammonium , glutamic acid , and glutamine . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
126,
139
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
146,
155
]
} |
the lipopolysaccharide and lipid a of r. sphaeroides , however , were found to be neither toxic in mice nor pyrogenic in rabbits . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
4,
22
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
27,
34
]
} |
the protein , which we designate dna-binding protein ii , is most probably a major histone-line protein of h. influenzae . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
33,
52
]
} |
both inner and outer membrane proteins of haemophilus influenzae type b were labeled by iodination procedures believed to be specific for exposed surface proteins only . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
30,
38
]
} | {
"id": "C0025252",
"name": "surface",
"pos": [
146,
153
]
} |
production of hydrogen peroxide in the heme oxygenase reaction did not appear to be due to the bimolecular dismutation of superoxide anions but rather seemed to be due to dissociation of a `` '' peroxo '' '' species formed on heme or intermediates of heme degradation . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
23,
31
]
} | {
"id": "C0038836",
"name": "superoxide anions",
"pos": [
122,
139
]
} |
the ca2+ concentration required for half-maximum activation of actomyosin atpase with troponin containing cardiac troponin i was slightly higher than that with troponin containing skeletal troponin i . | NA | {
"id": "C0041199",
"name": "troponin",
"pos": [
86,
94
]
} | {
"id": "C0077401",
"name": "troponin i",
"pos": [
189,
199
]
} |
after cholesterol feeding , the cholesterol content of lower density lipoproteins increased in all the animals . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
6,
17
]
} | {
"id": "C0023824",
"name": "cholesterol",
"pos": [
32,
43
]
} |
a polar amino acid , such as tyr , ser , gly , glu , asp , gln , or asn , in position p1 . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
8,
18
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
41,
44
]
} |
a polar amino acid , such as tyr , ser , gly , glu , asp , gln , or asn , in position p1 . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
47,
50
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
59,
62
]
} |
the release of factor v , and perhaps other sequestered coagulation factors , by these immunoreactive cells at an inflammatory site , coupled with the ability of these cells to effect thrombin generation may explain the relationship between extravascular fibrin deposition and mononuclear cell accumulation in the pathog... | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
56,
75
]
} | {
"id": "C0040018",
"name": "thrombin",
"pos": [
184,
192
]
} |
glcn-idua-glcn-idua-glcn the linkage positions and anomeric configurations were assumed to be the same as in the polysaccharides from which the oligosaccharides originated . | NA | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
113,
128
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
144,
160
]
} |
analyses of ovostatin-enzyme complexes by sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that the quarter-subunit of ovostatin was cleaved into several fragments by those enzymes . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
22,
28
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
189,
196
]
} |
these results led us to propose that ovostatin inhibits metalloproteinases in preference to proteinases of other classes in a manner similar to alpha 2-macroglobulin ; | NA | {
"id": "C0025543",
"name": "metalloproteinases",
"pos": [
56,
74
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
92,
103
]
} |
in the fungus podospora anserina , two mutants with ribosomes apparently lacking one ribosomal protein were investigated using immunological techniques to determine whether these proteins were indeed missing . | NA | {
"id": "C0035552",
"name": "ribosomal protein",
"pos": [
85,
102
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
179,
187
]
} |
antibodies directed against the wild type ribosomal proteins apparently absent in the mutants were raised from two-dimensional gel spots containing these proteins . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
42,
60
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
154,
162
]
} |
immunological results have revealed in both mutants the presence of strongly altered ribosomal proteins which co-migrate with other wild type proteins on two-dimensional gel . | NA | {
"id": "C0035552",
"name": "ribosomal",
"pos": [
85,
94
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
142,
150
]
} |
substrate amino acids protected at about the same concentration as their km , while glycine protected at its ki concentration . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
10,
21
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
84,
91
]
} |
ethanol markedly inhibited leucyl-trna synthetase , and it inhibited phe- and glu-trna synthetases to some extent , but had only a small effect on several other aminoacyl-trna synthetases , elongation factors 1 and 2 , ribosomes , or the formation of eukaryotic initiation factor 2 . gtp . met-trnar ternary complex . | NA | {
"id": "C0023414",
"name": "leucyl-trna synthetase",
"pos": [
27,
49
]
} | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
161,
187
]
} |
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