text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
ethanol markedly inhibited leucyl-trna synthetase , and it inhibited phe- and glu-trna synthetases to some extent , but had only a small effect on several other aminoacyl-trna synthetases , elongation factors 1 and 2 , ribosomes , or the formation of eukaryotic initiation factor 2 . gtp . met-trnar ternary complex . | NA | {
"id": "C0017811",
"name": "glu-trna synthetases",
"pos": [
78,
98
]
} | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
161,
187
]
} |
purification and characterization of a cell-aggregating factor ( clusterin ) , the major glycoprotein in ram rete testis fluid . | NA | {
"id": "C0055966",
"name": "clusterin",
"pos": [
65,
74
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
89,
101
]
} |
the fibroblasts synthesized shortened pro-alpha 2 ( i ) chains and these shortened chains accounted for all the pro-alpha 2 ( i ) chains synthesized by the cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
4,
15
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
156,
161
]
} |
the mrna for the 67k gbp is found in fibroblasts that are treated by either alpha- , beta- , or gamma-interferon , but it is not detected in untreated cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
37,
48
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
151,
156
]
} |
1 ) the cells have different amounts of post-translational modifying enzymes , 2 ) the rate of prolylhydroxylation of different procollagen types is varied , and 3 ) the rate of chain association of pro-alpha chains of different collagen types is modulated . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
128,
139
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
229,
237
]
} |
gtp and guanylyl-5'-imidodiphosphate stimulated yeast adenylate cyclase , while a gdp analog , guanosine-5'-o- ( 2-thiodiphosphate ) , competitively inhibited this stimulation . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
0,
3
]
} | {
"id": "C0018366",
"name": "guanylyl",
"pos": [
8,
16
]
} |
if eif-2 x gdp is actually the complex released , then gef is absolutely required for eif-2 to cycle and it is therefore a new eukaryotic initiation factor . | NA | {
"id": "C0013729",
"name": "eif-2",
"pos": [
3,
8
]
} | {
"id": "C1136317",
"name": "eukaryotic initiation factor",
"pos": [
127,
155
]
} |
direct measurement of [ 3h ] guanine nucleotide release from oocyte membranes preloaded with [ 3h ] gtp demonstrated that treatment with either progesterone or 2',5'-dideoxyadenosine slows the rate of nucleotide exchange . | NA | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
29,
47
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
100,
103
]
} |
peptide fragments of acth- ( 1-39 ) which were formed during in vitro incubation of the peptide with membrane preparations were isolated by high pressure liquid chromatography and characterized by determination of amino acid composition and nh2- terminal residue . | NA | {
"id": "C0030935",
"name": "peptide fragments",
"pos": [
0,
17
]
} | {
"id": "C0030956",
"name": "peptide",
"pos": [
88,
95
]
} |
this is observed both in the absence of intravesicular cations and in the presence of intravesicular k or rb ions . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
55,
62
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
109,
113
]
} |
rather , their uncoupler-like activity derives from their ability to form lipophilic ion pairs with certain anions . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
85,
88
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
108,
114
]
} |
glycosidase treatment did not reduce the antiviral activity of ifn-gamma in cultures of human fibroblasts and in bat lung cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
94,
105
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
122,
127
]
} |
the horseradish peroxidase-catalyzed n-demethylation reaction could be supported by a variety of hydroperoxides , peroxides , and peracids . | NA | {
"id": "C0020281",
"name": "hydroperoxides",
"pos": [
97,
111
]
} | {
"id": "C0031180",
"name": "peroxides",
"pos": [
114,
123
]
} |
polyacrylamide gel electrophoresis studies using 125i-factor xii as a marker show that the appearance of amidolytic activity correlates with factor xii cleavage , that activation goes to completion and that virtually all factor xiia formed is present as the two-chain , 80,000 mr form , alpha-factor xiia . | NA | {
"id": "C0015525",
"name": "factor xii",
"pos": [
54,
64
]
} | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
293,
304
]
} |
rigorous analysis of kinetic data establishes that , between 0.02 and greater than 90 % of the reaction , the activation of factor xii is described by a mechanism of autoactivation of factor xii by factor xiia . | NA | {
"id": "C0015525",
"name": "factor xii",
"pos": [
124,
134
]
} | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
198,
209
]
} |
these findings suggest that the concentrations of factor xii and factor xiia bound to the sulfatide surface determine the rate of autoactivation . | NA | {
"id": "C0015525",
"name": "factor xii",
"pos": [
50,
60
]
} | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
65,
76
]
} |
thus , sulfatide-dependent activation of purified factor xii is not due to contaminating proteases and is described by a second order mechanism of autoactivation due to the action of surface-bound factor xiia on surface-bound factor xii . | NA | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
197,
208
]
} | {
"id": "C0015525",
"name": "factor xii",
"pos": [
226,
236
]
} |
enzyme fully modified with 2-azido-amp was isolated and observed to have a similar conformation and to undergo similar ligand-induced conformational changes as the native enzyme-amp complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
0,
6
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
171,
177
]
} |
trifluoroacetyl dipeptide anilides have been synthesized and used to map the s ' subsites of porcine pancreatic elastase and human leucocyte elastase . | NA | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
101,
120
]
} | {
"id": "C0064833",
"name": "human leucocyte elastase",
"pos": [
125,
149
]
} |
the surface charge of isolated apolipoprotein a-i , apo-a-ii , apo-c-ii , and apo-c-iii2 as well as of liposomes from synthetic highly purified phospholipids and isolated very low density lipoprotein ( vldl ) particles from different donors ( n = 35 ) was determined by polyelectrolyte titration . | NA | {
"id": "C0052190",
"name": "apo-c-ii",
"pos": [
63,
71
]
} | {
"id": "C0003594",
"name": "apo-c",
"pos": [
78,
83
]
} |
the differences between experimental and calculated results for apo-c-ii and apo-c-iii2 are believed to result from `` '' polyelectrolyte '' '' effects of neighboring charged centers within the protein molecule causing a decrease of dissociation of carboxylic residues . | NA | {
"id": "C0052190",
"name": "apo-c-ii",
"pos": [
64,
72
]
} | {
"id": "C0003594",
"name": "apo-c",
"pos": [
77,
82
]
} |
dna molecules with topological knots can be detected in a reaction mixture of circular dna and type ii dna topoisomerase purified from the embryos of drosophila melanogaster . | NA | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
0,
13
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
78,
90
]
} |
similar to the dna knotting reaction by bacteriophage t4-induced topoisomerase ( liu , l. f. , liu , c. c. , and alberts , b. m. ( 1980 ) cell 19 , 697-707 ) , the knotting reaction by the drosophila topoisomerase ii requires a high ratio of enzyme/dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
15,
18
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
251,
252
]
} |
amber mutations occurring within the bacteriorhodopsin gene were localized by replacing the beta-galactosidase region of each mutant plasmid with a beta-galactosidase region which was known to be unmutated . | NA | {
"id": "C0005220",
"name": "beta-galactosidase",
"pos": [
92,
110
]
} | {
"id": "C0016955",
"name": "galactosidase",
"pos": [
153,
166
]
} |
our results indicate that the tsb201 nucleoproteins consist of capsid proteins , with varying extents of polymerization , held to chromatin by electrostatic bonds . | NA | {
"id": "C0028612",
"name": "nucleoproteins",
"pos": [
37,
51
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
130,
139
]
} |
the accumulation of these nucleoproteins is consistent with a simian virus 40 morphogenetic pathway wherein the capsid proteins are added gradually to the 75 s chromatin . | NA | {
"id": "C0028612",
"name": "nucleoproteins",
"pos": [
26,
40
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
160,
169
]
} |
we report here the preparation of monoclonal antibodies to partially purified 34-kda protein and to a heretofore unrecognized phosphoprotein that is not a pp60src target . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
85,
92
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
126,
140
]
} |
although the biologic effects of the 1,25- ( oh ) 2d3 hormone in 3t6 fibroblasts are as yet unknown , the present findings support previous work with 1,25- ( oh ) 2d3 receptors and suggest that this cell represents a good model for the study of nuclear events associated with the molecular action of 1,25- ( oh ) 2d3 . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
69,
80
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
199,
203
]
} |
the reaction products in the medium were ceramide and a mixture of water-soluble compounds such as phosphorylcholine and choline . | NA | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
99,
116
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
121,
128
]
} |
prostaglandin e ( pge ) receptor density in hepatic plasma membranes can be down-regulated by in vivo exposure to the 16,16-dimethyl analog of pge2 , and this is associated with desensitization of pge-sensitive adenylate cyclase . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
143,
147
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
197,
200
]
} |
these results indicate that mg2+ is not essential for the turnover of the calcium pump atpase . | NA | {
"id": "C0001476",
"name": "calcium pump",
"pos": [
74,
86
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
87,
93
]
} |
the possibilities that the alpha-hfa preparation was contaminated by rabbit kallikrein or that the human high mr kininogen preparation was contaminated by human prekallikrein were excluded by using specific antibodies ( igg ) against these proteins . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
76,
86
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
161,
174
]
} |
collectively , these results implicate a role for dietary vitamin d3 in maintaining a specified composition and topology of both the brush-border membrane proteins as well as its associated cytoskeletal core proteins , which is possibly important for intestinal calcium transport . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
155,
163
]
} | {
"id": "C0010852",
"name": "cytoskeletal",
"pos": [
190,
202
]
} |
for study of the time order of glycosylation , formation of complex oligosaccharides and proteolytic maturation as well as the site of proteolytic maturation of cathepsin d , fibroblasts were subjected to pulse-chase labeling , and cathepsin d was isolated from either total cell extracts or subcellular fractions by imm... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
175,
186
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
295,
299
]
} |
rce-t1 cells are virogenic when fused with chicken embryo fibroblasts ( cef ) and do not produce infectious virus as demonstrated by the absence of detectable virus in culture fluid from these cells alone . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
58,
69
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
193,
198
]
} |
to determine whether this group of proteins was sufficient for the assembly of the native beaded nucleoprotein structure , we dissociated 30s hnrnp purified from mouse ascites cells into their component proteins and rna by treatment with the ionic detergent sodium deoxycholate and then reconstituted this complex by add... | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
97,
110
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
203,
211
]
} |
addition of suitable concentrations of preformed purine bases ( mainly adenine ) , completely removes the block of the g1-s transition produced either by the excess of oxidizable substrates or by antimycin a . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
49,
55
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
71,
78
]
} |
the cellular density of transformed cells within the fpcl was eight times greater than that of fpcl made with normal rat cells . | NA | {
"id": "C0016030",
"name": "fpcl",
"pos": [
53,
57
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
110,
116
]
} |
normal rat fibroblasts elongated and flattened more , and organized the collagen matrix to a greater degree , than did transformed cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
11,
22
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
131,
136
]
} |
all the adrenergic agonists tested were found to stimulate smc growth , with an activity classified by decreasing order as follows : norepinephrine greater than epinephrine greater than isoproterenol . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
133,
147
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
161,
172
]
} |
effective functional compartmentation of atp could result from the binding of creatine kinase to cellular organelles ( e.g. , myofibrils and mitochondria ) such that high energy charge at the myofibrils is maintained by the reverse creatine kinase reaction , while phosphocreatine is synthesized mainly at the mitochondr... | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
78,
86
]
} | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
265,
280
]
} |
phosphocreatine was present in all cells , but the regulation of energy metabolism and energy shuttle by creatine-phosphocreatine-creatine kinase could be operative only in the cells where the mitochondrial creatine kinase is present . | NA | {
"id": "C0010287",
"name": "creatine",
"pos": [
7,
15
]
} | {
"id": "C0914594",
"name": "mitochondrial creatine kinase",
"pos": [
193,
222
]
} |
after prolonged exposure of mouse epididymal epithelial cells to a solution of osmium tetroxide , reduced osmium compounds were detected in the golgi cisternae and in the cytoplasm adjacent to the golgi complex . | NA | {
"id": "C0029385",
"name": "osmium tetroxide",
"pos": [
79,
95
]
} | {
"id": "C0206372",
"name": "osmium compounds",
"pos": [
106,
122
]
} |
recoveries of nd , dzp and czp ( as nd ) are essentially quantitative at all levels investigated . | NA | {
"id": "C0012010",
"name": "dzp",
"pos": [
19,
22
]
} | {
"id": "C0011279",
"name": "nd",
"pos": [
36,
38
]
} |
lipoprotein compositional analysis showed that estrogen administration caused significant increases in all vldl and hdl constituents ( protein , cholesterol , phospholipid , and triglyceride ) as well as vldl apolipoprotein ( apo ) b ( 118.9 % increase ) and hdl apoa-i ( 27.4 % increase ) . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
0,
11
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
204,
208
]
} |
to explore the effect of puberty on the somatomedins ( sms ) , a group of insulin-like peptides which mediate the action of gh on skeletal tissue , we measured sm-c/insulin-like growth factor-i ( sm-c/igf-i ) and igf-ii by specific rias in 110 adolescents between the ages of 10 and 18 yr . | NA | {
"id": "C0037657",
"name": "somatomedins",
"pos": [
40,
52
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
213,
218
]
} |
to explore the effect of puberty on the somatomedins ( sms ) , a group of insulin-like peptides which mediate the action of gh on skeletal tissue , we measured sm-c/insulin-like growth factor-i ( sm-c/igf-i ) and igf-ii by specific rias in 110 adolescents between the ages of 10 and 18 yr . | NA | {
"id": "C0037657",
"name": "somatomedins",
"pos": [
40,
52
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
213,
219
]
} |
given acutely iv , verapamil in amounts sufficient to produce plasma concentrations of approximately 200 ng/ml significantly blunted the pressor action of angiotensin ii in six normal subjects but did not alter increments in plasma aldosterone or cortisol in response to either angiotensin or acth compared to paired con... | NA | {
"id": "C0003009",
"name": "angiotensin",
"pos": [
155,
166
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
278,
289
]
} |
six hips were abnormal on naked eye examination in fetuses with polycystic kidneys , multiple deformities , or cyclopia . | NA | {
"id": "C0022680",
"name": "polycystic kidneys",
"pos": [
64,
82
]
} | {
"id": "C0000772",
"name": "multiple",
"pos": [
85,
93
]
} |
the antigen used was purified from the cell wall of candida albicans strain a and contained greater than 96 % polysaccharide mannan . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
110,
124
]
} | {
"id": "C0024727",
"name": "mannan",
"pos": [
125,
131
]
} |
the antibody production to mannan was specific , since an antigenically unrelated polysaccharide ( pneumococcal antigen s iii ) did not bind to methylated bovine serum albumin-mannan-induced blast cells and did not induce antimannan antibody-containing cells . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
82,
96
]
} | {
"id": "C0024727",
"name": "mannan",
"pos": [
226,
232
]
} |
stimulation of donor lymphocytes for 7 d in vitro with irradiated leukemia cells , leukemia cells plus allogeneic irradiated lymphocytes , or a pool of irradiated lymphocytes from 10 donors , did not activate any cytotoxic cells able to destroy the hla identical leukemic blasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
75,
80
]
} | {
"id": "C3485979",
"name": "cells",
"pos": [
223,
228
]
} |
endotoxin ( salmonella enteritidis lipopolysaccharide ( lps ) w or escherichia coli 0111 : b4 lps w , 0.01-1.0 micrograms/ml ) was added to culture dishes for 4-6 h . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
0,
9
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
94,
97
]
} |
so far there have been few investigations on gfa protein in relation to scrapie and analogous spongiform encephalopathies although there has been a need for an unequivocal method for the discrimination of different types of glia in these diseases . | NA | {
"id": "C0036457",
"name": "scrapie",
"pos": [
72,
79
]
} | {
"id": "C0162534",
"name": "spongiform encephalopathies",
"pos": [
94,
121
]
} |
coal tar phototherapy for psoriasis reevaluated : erythemogenic versus suberythemogenic ultraviolet with a tar extract in oil and crude coal tar . | NA | {
"id": "C0039315",
"name": "tar",
"pos": [
5,
8
]
} | {
"id": "C0009137",
"name": "crude coal tar",
"pos": [
130,
144
]
} |
suberythemogenic uvb was also used adjunctively to compare the effects of a 5 % concentration of a tar extract in an oil base to 5 % crude coal tar in petrolatum or the oil base without tar . | NA | {
"id": "C0039315",
"name": "tar",
"pos": [
99,
102
]
} | {
"id": "C0009137",
"name": "crude coal tar",
"pos": [
133,
147
]
} |
the direct bilateral comparison of equal concentrations of tar extract in oil base versus crude coal tar in petrolatum in a suberythemogenic uv photo regimen revealed no statistical differences between treatments . | NA | {
"id": "C0039315",
"name": "tar",
"pos": [
59,
62
]
} | {
"id": "C0009137",
"name": "crude coal tar",
"pos": [
90,
104
]
} |
the significant , elemental alterations included an increase in phosphorus and calcium in the involved skin regions . | NA | {
"id": "C0013879",
"name": "elemental",
"pos": [
18,
27
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
64,
74
]
} |
the glycolipids are comprised of simple glycosphingolipids ( 17.2 % ) , mainly lactosyl- and glucosylceramides , and of neutral and sulfated glyceroglucolipids ( 82.8 % ) . | NA | {
"id": "C0017950",
"name": "glycolipids",
"pos": [
4,
15
]
} | {
"id": "C0017978",
"name": "glycosphingolipids",
"pos": [
40,
58
]
} |
the glycolipids are composed of simple glycosphingolipids ( 7.1 % ) , and of neutral and sulfated glyceroglucolipids ( 92.9 % ) . | NA | {
"id": "C0017950",
"name": "glycolipids",
"pos": [
4,
15
]
} | {
"id": "C0017978",
"name": "glycosphingolipids",
"pos": [
39,
57
]
} |
in addition , function of nonischemic , noninfarcted myocardium was studied at the base of the left ventricle in those with exercise-induced anteroapical ischemia ( n = 4 ) and those with anteroapical infarction ( n = 4 ) . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
154,
162
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
201,
211
]
} |
during exercise , there is an interplay between regional dysfunction from ischemia or infarction and regional hyperfunction of nonischemic myocardium which determines global performance . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
74,
82
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
86,
96
]
} |
infarct size was significantly less ( p less than 0.005 ) in pgi2-treated dogs compared with the control group , both as percent of left ventricle ( 8.1 versus 17.7 % ) and as percent of the hypoperfused zone ( 39.8 versus 77.3 % ) . | NA | {
"id": "C0021308",
"name": "infarct",
"pos": [
0,
7
]
} | {
"id": "C0022116",
"name": "hypoperfused",
"pos": [
191,
203
]
} |
a whole virus vaccine , a surface-antigen subunit adsorbed vaccine , or an aqueous surface-antigen subunit vaccine . | NA | {
"id": "C0042210",
"name": "vaccine",
"pos": [
14,
21
]
} | {
"id": "C0887892",
"name": "subunit",
"pos": [
99,
106
]
} |
these results suggest that b cells bearing receptors for an epitope undergo an initial triggering in response to polyvalent epitope regardless of the t dependence and/or immunogenicity of the antigen . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
60,
67
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
192,
199
]
} |
therefore , a nonimmunogenic polyvalent epitope-bearing molecule can deliver either an initial triggering signal or a tolerogenic signal , depending on the presence of anti-id antibody , and it is as efficient as a complete immunogen . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
40,
47
]
} | {
"id": "C0003320",
"name": "immunogen",
"pos": [
224,
233
]
} |
these results could not be ascribed to differences in antibody class or binding characteristics , because scatchard analysis demonstrated that these two igg2a antibodies have comparable avidity and that t cells bind each antibody in equivalent amounts . | NA | {
"id": "C0021017",
"name": "antibody class",
"pos": [
54,
68
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
221,
229
]
} |
although the cellular lineage of most fetal hematopoietic cells could be identified by this panel of reagents , a considerable number of fetal liver and bone marrow cells did not express any of these antigens , suggesting the possibility that they might represent early hematopoietic progenitor cells . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
13,
21
]
} | {
"id": "C0018956",
"name": "hematopoietic progenitor cells",
"pos": [
270,
300
]
} |
after 5-24 wk , antinuclear , anti-ss dna , thymocytotoxic , and rheumatoid factor-like antibodies were detected in association with hypergammaglobulinemia and with the occurrence of circulating immune complexes and cryoglobulins . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
88,
98
]
} | {
"id": "C0003313",
"name": "circulating",
"pos": [
183,
194
]
} |
we also measured antibodies to the s24 determinant in rabbit antisera to human , monkey , dog , bovine , and the large and small forms of rat mbp . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
17,
27
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
61,
69
]
} |
demonstration of wehi-3 growth factor activity , mast cell growth factor activity , p cell-stimulating factor activity , colony-stimulating factor activity , and histamine-producing cell-stimulating factor activity . | NA | {
"id": "C0021757",
"name": "p cell-stimulating",
"pos": [
84,
102
]
} | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
121,
146
]
} |
in addition , homogeneous il 3 had colony-stimulating factor activity , although only approximately 2 % of the total csf activity found in con a cm was associated with il 3 . | NA | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
35,
60
]
} | {
"id": "C0021757",
"name": "il 3",
"pos": [
168,
172
]
} |
the capacity of the hybridoma-derived maf ( mafh ) to induce tumoricidal activity increased 10 ( 3 ) to 10 ( 4 ) -fold when the lymphokine was encapsulated into liposomes . | NA | {
"id": "C0079786",
"name": "maf",
"pos": [
38,
41
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
128,
138
]
} |
of the three monoclonal antibodies that failed to react with bm12 cells , two antibodies ( 25-9-17 and 34-5-3 ) were found to bind the same steric site on iab molecules ( cluster i ) . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
13,
34
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
78,
88
]
} |
mononuclear cells , nylon wool-filtered cells , plastic-nonadherent cells , and plastic-adherent cells from normal donors were radiolabeled by using 125i and lactoperoxidase . | NA | {
"id": "C0028736",
"name": "nylon",
"pos": [
20,
25
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
80,
87
]
} |
studies with partially purified c3 convertase decay-accelerating factors from eh stroma demonstrated that these membrane proteins could not account for the observed surface regulation of cp activity because these proteins do not affect the rate of c2 cleavage by eac14 . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
112,
129
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
213,
221
]
} |
the interaction of c3b bound to pneumococci with factor h ( beta 1h globulin ) , factor i ( c3b/c4b inactivator ) , and properdin factor b of the human complement system . | NA | {
"id": "C0056207",
"name": "factor h",
"pos": [
49,
57
]
} | {
"id": "C0005157",
"name": "beta",
"pos": [
60,
64
]
} |
the interaction of c3b bound to pneumococci with factor h ( beta 1h globulin ) , factor i ( c3b/c4b inactivator ) , and properdin factor b of the human complement system . | NA | {
"id": "C0033453",
"name": "properdin factor b",
"pos": [
120,
138
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
152,
162
]
} |
in the present study , we examined the interactions of c3b bound to pneumococcal capsules , to pneumococcal cell walls , and to the surface of sheep erythrocytes ( e ) with the serum control proteins , factor h ( beta 1h globulin ) ( h ) and factor i ( c3b/4b inactivator ) ( i ) , and with factor b ( b ) of the alterna... | NA | {
"id": "C0056207",
"name": "factor h",
"pos": [
202,
210
]
} | {
"id": "C0005157",
"name": "beta",
"pos": [
213,
217
]
} |
induction of granulocyte histaminase release by particle-bound complement c3 cleavage products ( c3b , c3bi ) and igg . | NA | {
"id": "C0009506",
"name": "complement c3",
"pos": [
63,
76
]
} | {
"id": "C0009511",
"name": "c3b",
"pos": [
103,
106
]
} |
lectin precipitation using antilectin conjugates or bead-bound lectins indicated that many of the labeled surface components are glycoproteins including the two major proteins precipitated by rabbit antisera . | NA | {
"id": "C0023206",
"name": "lectins",
"pos": [
63,
70
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
167,
175
]
} |
purified clostridium histolyticum collagenase was also able to mimic the enhancing effect of schistosome proteases , suggesting involvement of a collagenase-like activity of the enzymes in the eosinophil stimulation . | NA | {
"id": "C0009053",
"name": "clostridium histolyticum collagenase",
"pos": [
9,
45
]
} | {
"id": "C0162745",
"name": "collagenase",
"pos": [
145,
156
]
} |
the failure to induce enhancement was not due to inefficient antigen binding in vivo , because monoclonal antibodies were as effective as conventional b10.d2 anti-b10.a serum in the induction of acute antibody-mediated graft rejection , and in the opsonization of 51cr-labeled b10.a leukocytes injected into b10.d2 recip... | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
95,
116
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
342,
350
]
} |
in the present study , rats treated with this antibody showed a parallel decrease in nk activity and in the frequency of large granular lymphocytes ( lgl ) in the spleen and peripheral blood , indicating that the antiserum-induced depression of nk activity in these sites was probably caused by an elimination of most ef... | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
46,
54
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
213,
222
]
} |
these results indicate that the three rat monoclonal antibodies define different antigens present on macrophages at different stages of activation for tumor cytotoxicity , and that these antibodies should prove to be useful probes for analyzing the mechanism of activation of macrophages for tumor cytotoxicity . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
42,
63
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
187,
197
]
} |
the antidecapeptide antibodies induced by all three immunogens shared the same fine specificities and immunoglobulin isotype composition . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
20,
30
]
} | {
"id": "C0021017",
"name": "immunoglobulin isotype",
"pos": [
102,
124
]
} |
murine fetal liver and adult bone marrow cells identified by monoclonal 14.8 antibody were enriched on antibody-coated polystyrene petri dishes . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
61,
71
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
103,
111
]
} |
the enriched cells did not contain significant numbers of committed granulocyte-macrophage progenitor cells or putative hemopoietic stem cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
13,
18
]
} | {
"id": "C0018956",
"name": "hemopoietic stem cells",
"pos": [
120,
142
]
} |
the present studies describe the preparation and characterization of rabbit anti-idiotypic antibody against human igm anti-igg autoantibodies ( rheumatoid factors , rf ) that bear the `` '' internal image '' '' of the human igg-fc fragment , and hence react specifically with the majority of rf from patients with rheuma... | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
127,
141
]
} | {
"id": "C0035448",
"name": "f",
"pos": [
67,
68
]
} |
the anti-idiotype dose dependently blocked the binding to igg of igm-rf in 83 % of sera from multiple patients with rheumatoid arthritis , sjogren 's syndrome , and macroglobulinemia . | NA | {
"id": "C0003873",
"name": "rheumatoid",
"pos": [
116,
126
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
139,
158
]
} |
the t cell hybridoma fs7-20 , produced by the fusion of normal b10.br t cells to the akr thymoma bw5147 , was found when stimulated with concanavalin a ( con a ) to produce the lymphokines : interleukin 2 ( il 2 ) , interferon-gamma ( ifn gamma ) , macrophage-activating factor ( maf ) , ia induction factor iaif ) , and... | NA | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
177,
188
]
} | {
"id": "C0079786",
"name": "macrophage-activating factor",
"pos": [
249,
277
]
} |
most importantly , both maf could be differentiated serologically by a rabbit anti-lymphokine antiserum that selectively inhibited maf 96 but not maf 7.1.2 e8 activity . | NA | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
83,
93
]
} | {
"id": "C0079786",
"name": "maf",
"pos": [
146,
149
]
} |
isolated dog mastocytoma cells sensitized with dog anti-ragweed ige and challenged with ragweed antigen generate the c-6 peptide leukotriene ( lt ) constituents of the slow-reacting substance of anaphylaxis ( srs-a ) , ltc4 and ltd4 , and the potent leukocyte chemotactic factor , ltb4 , as well as 15-hydroxyeicosatetra... | NA | {
"id": "C0023545",
"name": "leukotriene",
"pos": [
129,
140
]
} | {
"id": "C0038091",
"name": "of",
"pos": [
192,
194
]
} |
isolated dog mastocytoma cells sensitized with dog anti-ragweed ige and challenged with ragweed antigen generate the c-6 peptide leukotriene ( lt ) constituents of the slow-reacting substance of anaphylaxis ( srs-a ) , ltc4 and ltd4 , and the potent leukocyte chemotactic factor , ltb4 , as well as 15-hydroxyeicosatetra... | NA | {
"id": "C0038091",
"name": "of",
"pos": [
161,
163
]
} | {
"id": "C0023542",
"name": "ltc4",
"pos": [
219,
223
]
} |
isolated dog mastocytoma cells sensitized with dog anti-ragweed ige and challenged with ragweed antigen generate the c-6 peptide leukotriene ( lt ) constituents of the slow-reacting substance of anaphylaxis ( srs-a ) , ltc4 and ltd4 , and the potent leukocyte chemotactic factor , ltb4 , as well as 15-hydroxyeicosatetra... | NA | {
"id": "C0038091",
"name": "of",
"pos": [
161,
163
]
} | {
"id": "C0023544",
"name": "ltd4",
"pos": [
228,
232
]
} |
isolated dog mastocytoma cells sensitized with dog anti-ragweed ige and challenged with ragweed antigen generate the c-6 peptide leukotriene ( lt ) constituents of the slow-reacting substance of anaphylaxis ( srs-a ) , ltc4 and ltd4 , and the potent leukocyte chemotactic factor , ltb4 , as well as 15-hydroxyeicosatetra... | NA | {
"id": "C0020349",
"name": "hydroxyeicosatetraenoic acid",
"pos": [
302,
330
]
} | {
"id": "C0044800",
"name": "12-hete",
"pos": [
345,
352
]
} |
thus , the precursors of p cells and probably of at least the t cell-dependent subset of mast cells appear to be generated in the bone marrow and seed as non-granulated cells via the blood to peripheral tissues such as spleen , lymph node , and mucosal surfaces . | NA | {
"id": "C0018956",
"name": "precursors",
"pos": [
11,
21
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
169,
174
]
} |
in seven individuals ( mean 601 eggs/g ) , the depletion of adherent cells from peripheral blood mononuclear cells ( pbmc ) increased blastogenic responses to soluble worm antigenic preparation ( swap ) from a stimulation index ( si ) of 3.2 +/- 1.0 to 11.0 +/- 3.0 ( p less than 0.01 ) . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
43,
46
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
80,
114
]
} |
antibodies to the allergen dpt 12 from dermatophagoides pteronyssinus have been demonstrated in commercially obtained rabbit anti-human ige , igg and iga antisera and in a commercially obtained rabbit anti-mouse igg1 antiserum using either double or triple antibody radioimmunoassays . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
217,
226
]
} |
to better understand the functional significance of individual keratin species , we have generated three monoclonal antikeratin antibodies to different subsets of keratins and used these antibodies to localize specific keratins in normal human epidermis by a combination of immunohistochemical and biochemical techniques... | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
105,
115
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
187,
197
]
} |
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