text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
a comparison of the 50 k keratin sequence with the partial sequences known for other intermediate-filament proteins indicates that the keratins may be the most distantly related of this class of 80- to 100-a filamentous proteins . | NA | {
"id": "C0021769",
"name": "intermediate-filament",
"pos": [
85,
106
]
} | {
"id": "C0010803",
"name": "keratins",
"pos": [
135,
143
]
} |
it consists of two components : ( 1 ) a dermal equivalent made up of fibroblasts in a collagen matrix that is contracted and modified by the resident cells , and ( 2 ) an epidermis that develops from keratinocytes `` '' plated '' '' on the dermal equivalent . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
69,
80
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
150,
155
]
} |
although keratinocytes in liquid simulate many of the typical and important characteristics observed in these cells in vivo , the conditions required to reproduce other important functions of keratinocytes have not yet been defined . | NA | {
"id": "C0022567",
"name": "liquid",
"pos": [
26,
32
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
110,
115
]
} |
at high levels of vitamin a and other retinoids ( 3 x 10 ( -6 ) m ) attachment of human keratinocytes to 3t3-coated plastic dishes is mildly inhibited . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
18,
27
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
38,
47
]
} |
in the early proliferative phase , the stromal cells had the characteristics of mesenchymal cells but in the early secretory phase , they resembled fibroblasts . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
3,
6
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
148,
159
]
} |
when okumura 's method of classification according to temperature sensitivity is applied , the choriocarcinoma cells may be regarded as having the characteristics of adenocarcinoma . | NA | {
"id": "C0008497",
"name": "choriocarcinoma",
"pos": [
95,
110
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
166,
180
]
} |
a statistically significant correlation was found between the position of the main peak and the occurrence of secondary trophoblastic disease from hydatidiform mole . | NA | {
"id": "C2931618",
"name": "trophoblastic disease",
"pos": [
120,
141
]
} | {
"id": "C0020217",
"name": "hydatidiform",
"pos": [
147,
159
]
} |
histological grading of hydatidiform mole did not show a good correlation with regard to the occurrence of secondary trophoblastic disease from hydatidiform mole . | NA | {
"id": "C2931618",
"name": "trophoblastic disease",
"pos": [
117,
138
]
} | {
"id": "C0020217",
"name": "hydatidiform mole",
"pos": [
144,
161
]
} |
however , incorporation of 14c-proline into collagen hydroxyproline was elevated only in elastase-treated lungs over the period of 21 to 360 days . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
31,
38
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
53,
67
]
} |
the results indicated that the presence of hb f , hb s , and hb c did not affect the glyco hb determinations . | NA | {
"id": "C0015936",
"name": "hb",
"pos": [
43,
45
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
91,
93
]
} |
the sum of the squared correlation coefficients with these latter uncorrelated variables equaled 0.87 and partial correlation coefficient analyses demonstrated an increase in the correlation of the ascitic fluid protein with the serum albumin concentration when corrected for serum globulin and ( s-asc ) a ( r = 0.97 ; ... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
212,
219
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
235,
242
]
} |
of other steroids investigated , progesterone in high concentrations ( 3 x 10 ( -6 mol/l ) suppressed to a small extent the functional activity of the hypothalamus in vitro but 17 alpha-hydroxyprogesterone , 11 alpha-hydroxyprogesterone , 11 alpha , 17 alpha-dihydroxyprogesterone and 11-epicortisol had no effect on the... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
33,
45
]
} | {
"id": "C0002328",
"name": "dihydroxyprogesterone",
"pos": [
259,
280
]
} |
the most extensive staining for iga and igg in the myometrium and endometrium occurred during pro-oestrus and plasma cells of both isotype were concentrated around the uterine glands and lumen in high numbers at this time . | NA | {
"id": "C0020852",
"name": "igg",
"pos": [
40,
43
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
131,
138
]
} |
however , it markedly increased the dopamine turnover rate of primed rats , thus reversing the inhibitory action of oestradiol benzoate on the dopaminergic system of the poah . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
36,
44
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
143,
155
]
} |
besides immunological cross-reactivity , relatedness between all four immune-precipitated proteins was indicated by a greater than 50 % tryptic peptide homology , suggesting that the mr 230,000 component represents a precursor protein that is cleaved within the infected erythrocyte into proteins with mr of approximatel... | NA | {
"id": "C0033665",
"name": "precursor protein",
"pos": [
217,
234
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
288,
296
]
} |
evidence is presented that m phi complement receptors ( cr3 ) mediate igm-dependent enhancement of flavivirus replication in the presence of complement . | NA | {
"id": "C0034793",
"name": "complement receptors",
"pos": [
33,
53
]
} | {
"id": "C0079785",
"name": "cr3",
"pos": [
56,
59
]
} |
at the non-permissive temperature ( 41 degrees c ) , there was no viral rna synthesis or ifn induction by u.v.-treated virions except for ts-3 ( rna+ ) , which did synthesize rna at 41 degrees c , and whose u.v.-treated virions did induce ifn at this temperature . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
66,
75
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
175,
178
]
} |
two cases of recurrent major depression , three cases of dysthymic disorder ( depressive neurosis ) , and one of adjustment disorder with depressed mood beginning in childhood or adolescence have been identified in the 133 subjects of the new york longitudinal study . | NA | {
"id": "C0013415",
"name": "dysthymic disorder",
"pos": [
57,
75
]
} | {
"id": "C0011581",
"name": "depressive neurosis",
"pos": [
78,
97
]
} |
the levels of m-enk-arg6-phe7 in various structures of the rat brain were compared with the levels of several other opioid peptides , including methionine-enkephalin ( m-enk ) , leucine-enkephalin ( l-enk ) , dynorphin 1-13 , and alpha-neoendorphin , which were also measured by ria . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
116,
131
]
} | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
209,
218
]
} |
both ca2+-atpase and atp-dependent ca2+ uptake require calmodulin for maximal activity ( kcm for atpase = 60 nm ; kcm for uptake = 50 nm ) . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
5,
8
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
97,
103
]
} |
structure-activity relationships examined with synthetic formylated or acetylated peptides indicated no significant effects for di- or tripeptides if the second substituent was ala , ser , asn , or thr , but the activity was reduced 0.5-fold for leu , a branched-chain amino acid . | NA | {
"id": "C0023401",
"name": "leu",
"pos": [
246,
249
]
} | {
"id": "C0002521",
"name": "branched-chain amino acid",
"pos": [
254,
279
]
} |
the enzyme readily degrades a number of neuropeptides including substance p , neurotensin , thyrotropin-releasing hormone , and luteinizing hormone-releasing hormone . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
40,
53
]
} | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
78,
89
]
} |
anhydrous ammonia was mixed with the gas containing [ 15o ] o2 , and after preheating to about 200 degrees c was carried through an oven containing a pt catalyst kept at about 310 degrees c . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
10,
17
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
37,
40
]
} |
ligand : zinc ratios equal to or less than 3:1 were optimal for amino acids and dipeptides such as l-glutamate , glycine , l-histidine , l-tryptophan and glycylglycine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
64,
75
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
160,
167
]
} |
ligand : zinc ratios equal to or less than 3:1 were optimal for amino acids and dipeptides such as l-glutamate , glycine , l-histidine , l-tryptophan and glycylglycine . | NA | {
"id": "C0012512",
"name": "dipeptides",
"pos": [
80,
90
]
} | {
"id": "C0017984",
"name": "glycylglycine",
"pos": [
154,
167
]
} |
the dietary effect of omega-3 type highly polyunsaturated fatty acid concentrate ( pufa mix ) was investigated on cholesterol and triglyceride levels in the serum and liver , and high density lipoprotein cholesterol ( hdl-cholesterol ) levels in the serum . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
114,
125
]
} | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
218,
233
]
} |
bleeding from the femoral vein did not produce a hematoma unless venous pressure was elevated by venous occlusion . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
0,
8
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
49,
57
]
} |
a closed circuit television movement detector was used to study mandibular movement in the form of tooth tapping , in subjects with no apparent dental disease or malocclusion . | NA | {
"id": "C0040435",
"name": "dental",
"pos": [
144,
150
]
} | {
"id": "C0024636",
"name": "malocclusion",
"pos": [
162,
174
]
} |
these data indicate that , except with severe mucosal injury and secondary monosaccharide intolerance , glucose polymers of the dextrose equivalents tested are suitable carbohydrate sources for infants recovering from acute diarrhea . | NA | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
75,
89
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
169,
181
]
} |
following incubation of the roots , in the presence of normal human gingival fibroblasts for varying periods of time , cells were assayed for viability by radioactive label ( 51cr ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
77,
88
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
119,
124
]
} |
the purpose of this investigation is to elucidate the relationship between the time course of pharmacologic effects and drug disposition after administration of metformin , an oral antidiabetic drug of biguanides . | NA | {
"id": "C0025598",
"name": "metformin",
"pos": [
161,
170
]
} | {
"id": "C0005382",
"name": "biguanides",
"pos": [
202,
212
]
} |
isdn was rapidly denitrated , giving rise to isosorbide-5-mononitrate ( 5-ismn ) as a major metabolite , and 2-ismn as a minor metabolite . | NA | {
"id": "C0022252",
"name": "isdn",
"pos": [
0,
4
]
} | {
"id": "C0064079",
"name": "5-ismn",
"pos": [
72,
78
]
} |
the findings support the concept that the concentrations of isdn , 2-ismn and 5-ismn in the blood are inversely related to the rates of denitration , and that the vascular activity of the nitrates of isosorbide relates to the rates of their dinitration . | NA | {
"id": "C0022252",
"name": "isdn",
"pos": [
60,
64
]
} | {
"id": "C0064079",
"name": "5-ismn",
"pos": [
78,
84
]
} |
the findings support the concept that the concentrations of isdn , 2-ismn and 5-ismn in the blood are inversely related to the rates of denitration , and that the vascular activity of the nitrates of isosorbide relates to the rates of their dinitration . | NA | {
"id": "C0022252",
"name": "isdn",
"pos": [
60,
64
]
} | {
"id": "C0022251",
"name": "isosorbide",
"pos": [
200,
210
]
} |
the findings support the concept that the concentrations of isdn , 2-ismn and 5-ismn in the blood are inversely related to the rates of denitration , and that the vascular activity of the nitrates of isosorbide relates to the rates of their dinitration . | NA | {
"id": "C0064079",
"name": "5-ismn",
"pos": [
78,
84
]
} | {
"id": "C0022251",
"name": "isosorbide",
"pos": [
200,
210
]
} |
the zinc ion is coordinated to two theophylline anions and a molecule of ethylenediamine in a tetrahedral arrangement . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
9,
12
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
48,
54
]
} |
to elucidate the details of the esterase activity of human serum albumin , the reaction of n-trans-cinnamoylimidazoles with albumin was investigated kinetically at various phs at 25 degrees . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
53,
72
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
124,
131
]
} |
the prodrug , 3-pentanoyloxymethyl-5,5-diphenylhydantoin when administered in tributyrin gave superior oral phenytoin bioavailability in rats when compared with sodium phenytoin administered as an aqueous solution . | NA | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
108,
117
]
} | {
"id": "C0237417",
"name": "sodium phenytoin",
"pos": [
161,
177
]
} |
the rapid reaction of human serum albumin with trinitrobenzenesulfonate ( i ) and the location of the reactive site were investigated to characterize the chemical modification of albumin by i . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
22,
41
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
179,
186
]
} |
these include alkanoic acids of various chain length and branching ( some solid at room temperature ) , cholesterol , and cholesteryl esters . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
104,
115
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
122,
140
]
} |
a desorption technique utilizing polyethylene glycol 4000 was used as a means of obtaining satisfactory spectra of ampicillin and amoxicillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
115,
125
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
130,
141
]
} |
therefore , furosemide binding by human albumin was examined using albumin fluorescence quenching by both the method of levine and the method of steiner et al . | NA | {
"id": "C0304925",
"name": "human albumin",
"pos": [
34,
47
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
67,
74
]
} |
a commercial antacid suspension containing aluminum hydroxide and magnesium hydroxide products was used as a model sample to study the use of a californium-252 thermal neutron activation as a method for quantifying aluminum content as well as for the simultaneous assay of aluminum and magnesium . | NA | {
"id": "C0024476",
"name": "magnesium",
"pos": [
66,
75
]
} | {
"id": "C0024467",
"name": "magnesium",
"pos": [
286,
295
]
} |
combined glc-mass spectrometry revealed that an unidentified sparteine isomer was the major component of an alkaloid extract of the aboveground portions of lupinus argenteus pursh . var . stenophyllus ( rydb . ) | NA | {
"id": "C0037760",
"name": "sparteine",
"pos": [
61,
70
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
108,
116
]
} |
after isolation , this alkaloid was characterized as the least common of the known sparteine isomers , ( - ) -alpha-isosparteine . | NA | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
23,
31
]
} | {
"id": "C0037760",
"name": "sparteine",
"pos": [
119,
128
]
} |
the antidiabetic action of phenformin and other related biguanides can be explained in terms of competition between these molecules and insulin to coordinate cationic oligoelements together with their ability to form hydrogen bonds between the biguanide moiety and insulin itself . | NA | {
"id": "C0031404",
"name": "phenformin",
"pos": [
27,
37
]
} | {
"id": "C0005382",
"name": "biguanide",
"pos": [
244,
253
]
} |
the cephalosporin antibiotics cephaloridine and cefazolin were examined for their effects on the transport of a prototype anion , [ 3h ] p-aminohippurate ( pah ) and a prototype cation , n1- [ 3h ] methylnicotinamide ( nmn ) in basolateral membrane vesicles and brush border membrane vesicles ( bbmv ) . | NA | {
"id": "C3536856",
"name": "cephalosporin antibiotics",
"pos": [
4,
29
]
} | {
"id": "C0007727",
"name": "cephaloridine",
"pos": [
30,
43
]
} |
low doses ( 0.2-3 nmol ) of both [ d-ala2 , mephe4 , gly- ( ol ) 5 ] enkephalin ( dago , mu-agonist ) and [ d-ala2 , d-leu5 ] enkephalin ( dadl , delta-agonist ) caused dose-dependent increases in blood pressure and heart rate which were naloxone reversible . | NA | {
"id": "C0525773",
"name": "dago",
"pos": [
82,
86
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
126,
136
]
} |
a short-term pretreatment of rats ( n = 7 ) with phenobarbital resulted in small but significant increases in the rates of metabolism of both barbiturates , whereas treatment of rats with 3-methylcholanthrene ( n = 5 ) resulted in a reversed effect . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
49,
62
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
142,
154
]
} |
to initiate studies of benzodiazepine tolerance and physical dependence , a reproducible animal model has been developed utilizing chlordiazepoxide in rats . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
23,
37
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
131,
147
]
} |
in an attempt to produce chronic , selective , pharmacological blockade of brain angiotensin ii ( aii ) receptors , we infused saralasin ( 1sar , 8ala-angiotensin ii ) , a competitive aii receptor antagonist , into the cerebral ventricles of rats for 5 days . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
127,
136
]
} | {
"id": "C0003009",
"name": "angiotensin",
"pos": [
151,
162
]
} |
aii , suggesting that i.c.v . saralasin acts as an agonist at central aii receptors in rats maintained on a high sodium intake . | NA | {
"id": "C0003009",
"name": "aii",
"pos": [
0,
3
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
30,
39
]
} |
the apparent agonistic activity of saralasin may limit its usefulness in assessing the physiological role of the central effects of aii . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
35,
44
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
132,
135
]
} |
stimulation of the sympathoadrenomedullary axis at the pressor period elicited by 1 nm dermorphin was evident by high circulating levels of epinephrine and norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
140,
151
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
156,
170
]
} |
tolerance develops to morphine bradycardia after s.c. infusions of morphine sulfate ( e.g. , 74 nmol/hr/rat s.c. for 2 days elevated the morphine ed50 by 22 times ) , but not after central infusions of morphine at doses which are sufficient to produce physical dependence and tolerance to morphine analgesia . | NA | {
"id": "C0066814",
"name": "morphine",
"pos": [
22,
30
]
} | {
"id": "C0026549",
"name": "morphine",
"pos": [
289,
297
]
} |
the effect of dibekacin is similar to that of the other aminoglycosides , but it would seem to be less nephrotoxic than gentamicin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
56,
71
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
120,
130
]
} |
[ effects of ca2+ and calmodulin inhibitors on lipolysis induced by epinephrine , norepinephrine , caffeine and acth in rat epididymal adipose tissue ] . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
68,
79
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
82,
96
]
} |
the effects of ca2+ and calmodulin inhibitors on lipolysis induced by epinephrine , norepinephrine , caffeine and acth in rat epididymal adipose tissue were investigated . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
70,
81
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
84,
98
]
} |
omission of ca2+ from the incubation medium slightly depressed lipolysis induced by epinephrine , norepinephrine and acth . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
84,
95
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
98,
112
]
} |
lipolysis induced by epinephrine , norepinephrine , caffeine and acth was strongly depressed when ca2+-deficient tissue was incubated in ca2+-free ringer solution . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
21,
32
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
35,
49
]
} |
in ca2+-deficient tissue , the addition of 0.75mm ca2+ apparently restored lipolysis induced by epinephrine , norepinephrine and acth , whereas that by caffeine was restored to only approximately 89 % . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
96,
107
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
110,
124
]
} |
these results strongly support the possible key role that the redistribution and influx of ca2+ may play in lipolysis induced by epinephrine , norepinephrine , caffeine and acth , and further suggest that calmodulin may affect lipolysis . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
129,
140
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
143,
157
]
} |
they were categorized according to five perceived weight groups with category one being underweight and category five being overweight . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
50,
56
]
} | {
"id": "C0497406",
"name": "overweight",
"pos": [
124,
134
]
} |
the two nucleosides with the purine joined at the n-9 position , namely , 6 and 8 , are easily distinguished from the other two nucleosides ( 7 and 9 ) , having n-7 junctions , by their nmr spectra . | NA | {
"id": "C0034136",
"name": "nucleosides",
"pos": [
8,
19
]
} | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
128,
139
]
} |
in five of the six variants , the 3 ' end of the vsg messenger rna differs from that of the corresponding basic copy gene by multiple point mutations , insertions and deletions , starting at positions varying from 16 nucleotides upstream to 113 downstream of the last codon of the mature protein . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
53,
66
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
268,
273
]
} |
pro13 , met43 and all the glu , gln , lys and arg , where only one or two resonances of c beta h2 and in some cases c gamma h2 could be identified . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
26,
29
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
32,
35
]
} |
by combined use of amino acid analysis , chemical sequence determination for the n-terminal decapeptide and two-dimensional 1h nuclear magnetic resonance at 500 mhz the amino acid sequence of bull seminal inhibitor iib was found to coincide with that of the isoinhibitor iia , except that the n-terminal tripeptide pyrl-... | NA | {
"id": "C0017984",
"name": "gly2",
"pos": [
320,
324
]
} | {
"id": "C0012512",
"name": "dipeptide",
"pos": [
356,
365
]
} |
satellite dna is not detectably linked to other dna and no transcripts of this dna are found in t. brucei . | NA | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
0,
13
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
79,
82
]
} |
these data indicate that the interaction of trnaphe with poly ( u ) -programmed 30 s ribosomes is primarily a result of contacts in the anticodon arm region and not with other parts of the transfer rna . | NA | {
"id": "C0003284",
"name": "anticodon",
"pos": [
136,
145
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
189,
201
]
} |
clathrin was purified from seven different bovine tissues using immunoaffinity columns prepared from a monoclonal antibody specific for the heavier light chain ( lca ) of bovine brain clathrin . | NA | {
"id": "C0008905",
"name": "clathrin",
"pos": [
0,
8
]
} | {
"id": "C0530079",
"name": "heavier",
"pos": [
140,
147
]
} |
replicative intermediates isolated from escherichia coli cells infected with p2 gene b mutants were circular dna molecules with single-stranded dna tails , as opposed to the double-stranded dna tails of wild-type replicative intermediates . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
100,
112
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
174,
193
]
} |
replicative intermediates isolated from escherichia coli cells infected with p2 gene b mutants were circular dna molecules with single-stranded dna tails , as opposed to the double-stranded dna tails of wild-type replicative intermediates . | NA | {
"id": "C0012935",
"name": "dna",
"pos": [
109,
112
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
174,
193
]
} |
human simian virus 80 ( sv80 ) cells transformed by simian virus 40 ( sv40 ) synthesize substantial quantities of the sv40 large t-antigen ( henderson & livingston , 1974 ; tjian , 1978 ) and cytoplasmic , poly ( a ) -containing rna species that exhibit spliced structures characteristic of the sv40 , early messenger rn... | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
229,
232
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
308,
321
]
} |
these findings lead us to the proposal that the majority of the cytoplasmic poly ( a ) rna in echinoderm eggs and early embryos is similar in form to rnas that occur in the nucleus rather than to the messenger rna of later cells . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
87,
90
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
200,
213
]
} |
the circular dna is resistant to the action of escherichia coli exonuclease iii and t7 exonuclease , but becomes sensitive to these nucleases after treatment with pronase showing the presence of a protein that binds non-covalently to the ends of the dna to circularize it as well as protect it from digestion with exonuc... | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
4,
16
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
250,
253
]
} |
examination of dna from mature phage particles reveals that a circular dna species is present in at least 0.1 to 1 % of the population . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
15,
18
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
62,
74
]
} |
the operative mortality was 3.4 percent for the group with stable angina and 15 percent for the unstable group.at follow-up , 73 percent of the patients had no angina . | NA | {
"id": "C0340288",
"name": "stable",
"pos": [
59,
65
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
160,
166
]
} |
these observations further indicate that the fibroblasts migrate from the interior regions of the gel matrix and eventually form a monolayer of cells encapsulating the contracted collagen disc . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
45,
56
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
144,
149
]
} |
the 104-s antibody also weakly precipitated the 130,000-molecular-weight herpes simplex virus type 1 ( hsv-1 ) glycoprotein gc from both infected cell extracts and purified preparations obtained through the use of monoclonal antibody-containing immunoadsorbent columns . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
10,
18
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
214,
233
]
} |
bacterial infection and male infertility : absence of immunoglobulin a with specificity for common escherichia coli 0-serotypes in seminal fluid of infertile men . | NA | {
"id": "C0021364",
"name": "male infertility",
"pos": [
24,
40
]
} | {
"id": "C0021359",
"name": "infertile",
"pos": [
148,
157
]
} |
ultracentrifugation of plasma lipoproteins revealed a marked increase in chylomicron + vldl ( very low density lipoprotein ) fraction . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
30,
42
]
} | {
"id": "C0008731",
"name": "chylomicron",
"pos": [
73,
84
]
} |
ultracentrifugation of plasma lipoproteins revealed a marked increase in chylomicron + vldl ( very low density lipoprotein ) fraction . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
30,
42
]
} | {
"id": "C0023825",
"name": "very low density lipoprotein",
"pos": [
94,
122
]
} |
the combination of a systemic virus infection , epithelial alterations that impaired clearance mechanisms , and immunologic dysfunction is likely to contribute to the inability of rabbits given mv to survive their gram-negative infection . | NA | {
"id": "C0243026",
"name": "systemic",
"pos": [
21,
29
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
228,
237
]
} |
binding of dmba from simple bile salt solution was greatest with delipidated bran greater than acid lignin greater than alpha-cellulose greater than unprocessed bran . | NA | {
"id": "C0023705",
"name": "lignin",
"pos": [
100,
106
]
} | {
"id": "C0007648",
"name": "alpha-cellulose",
"pos": [
120,
135
]
} |
cultures of x/gf or c57bl/6j embryonic fibroblasts were exposed to the chemical carcinogens 7,12-dimethylbenz [ a ] anthracene and benzo [ a ] pyrene to test whether the cells of the x/gf mouse are themselves resistant to oncogenesis . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
39,
50
]
} | {
"id": "C0007634",
"name": "the cells",
"pos": [
166,
175
]
} |
approximately 5 % of the patients had high-titer melanoma lda that was unchanged by surgical removal of the tumor , and 15 % had melanoma lda revealed in their sera only after the sera had been treated to dissociate immune complexes . | NA | {
"id": "C0003241",
"name": "lda",
"pos": [
58,
61
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
216,
232
]
} |
while some retrospective studies have found an association between high caffeine intake and fetal death , stillbirth , premature birth , and birth defects , others have not . | NA | {
"id": "C0015927",
"name": "fetal death",
"pos": [
92,
103
]
} | {
"id": "C0595939",
"name": "stillbirth",
"pos": [
106,
116
]
} |
the importance of certain oligopeptides ( angiotensin ii , bradykinin , renin , and delta-sheep-producing peptide ) in the genesis of cardiovascular disorders observed in the stimulation of the emotiogenic zones of the ventromedial hypothalamus has been elucidated . | NA | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
26,
39
]
} | {
"id": "C0030956",
"name": "peptide",
"pos": [
106,
113
]
} |
the increased plasma concentration in these lipoproteins is the cause of deposition of lipid in xanthomas and arterial wall , but the mechanism by which lipoprotein enters the cells in which lipid accumulates is not yet understood . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
44,
55
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
191,
196
]
} |
[ use of alpha-tocopherol acetate ( vitamin e ) and sodium nucleinate in the treatment of patients with stomach and duodenal ulcer ] . | NA | {
"id": "C1999896",
"name": "alpha-tocopherol acetate",
"pos": [
9,
33
]
} | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
36,
45
]
} |
experimentally induced gsd-like conditions have been described in the rat ( acarbose-induced gsd ii-like conditions , iodoacetate-induced symptoms of myophosphorylase ( gsd v ) and myophosphofructokinase ( gsd vii ) deficiency ) and the chicken ( ochratoxin a-induced symptoms of cyclic amp-dependent protein kinase defi... | NA | {
"id": "C0017921",
"name": "gsd ii",
"pos": [
93,
99
]
} | {
"id": "C0017919",
"name": "gsd",
"pos": [
206,
209
]
} |
the number of available estradiol binding sites in cytosol that are sensitive to agno3 correlate with ( a ) the number of estradiol-inhibitable binding sites found in the 8s region in low-salt sucrose gradients ( r = 0.9 ) but not with ( b ) estradiol-inhibitable binding in the 4s region ( r = 0.3 ) and thus , as expec... | NA | {
"id": "C0034803",
"name": "estradiol",
"pos": [
24,
33
]
} | {
"id": "C0034804",
"name": "estrogen binding sites",
"pos": [
384,
406
]
} |
the steroids progesterone ( p ) , androstenedione ( ad ) , pregnenolone ( pl ) , 5 alpha-dihydrotestosterone ( dht ) , dehydroepiandrosterone ( dhea ) , testosterone ( t ) , 11-deoxycorticosterone ( doc ) , 17-oh-progesterone ( 17-ohp ) , 17-oh-pregnenolone ( 17-pl ) , 11-deoxycortisol ( s ) , 18-oh-11-deoxycorticoster... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
13,
25
]
} | {
"id": "C0020387",
"name": "17-oh-progesterone",
"pos": [
207,
225
]
} |
the steroids progesterone ( p ) , androstenedione ( ad ) , pregnenolone ( pl ) , 5 alpha-dihydrotestosterone ( dht ) , dehydroepiandrosterone ( dhea ) , testosterone ( t ) , 11-deoxycorticosterone ( doc ) , 17-oh-progesterone ( 17-ohp ) , 17-oh-pregnenolone ( 17-pl ) , 11-deoxycortisol ( s ) , 18-oh-11-deoxycorticoster... | NA | {
"id": "C0376260",
"name": "17-oh-pregnenolone",
"pos": [
239,
257
]
} | {
"id": "C0373704",
"name": "pl",
"pos": [
573,
575
]
} |
the production of steroidogenic intermediates such as pregnenolone , progesterone , and 17 alpha-hydroxypregnenolone , as well as 17 alpha-hydroxyprogesterone , 11-deoxycortisol , and 11-deoxycorticosterone also was increased by short-term ( 12 h ) treatment with acth . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
54,
66
]
} | {
"id": "C0376260",
"name": "17",
"pos": [
130,
132
]
} |
acth also induced refractoriness in the production of other c21-steroids ( pregnenolone , progesterone , 17 alpha-hydroxypregnenolone , 17 alpha-hydroxyprogesterone , and 11-deoxycortisol ) as well as of c19-steroids ( dehydroepiandrosterone , androstenedione , and 11 beta-hydroxyandrostenedione ) . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
75,
87
]
} | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
105,
133
]
} |
adenylate cyclase activity in the basal state or in the presence of sodium fluoride , guanyl-5'-yl imidodiphosphate , or isoproterenol , with or without gtp , was not altered by the alloxan-induced diabetic state . | NA | {
"id": "C0018366",
"name": "guanyl-5",
"pos": [
86,
94
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
153,
156
]
} |
g. sylvestre therapy not only produced blood glucose homeostasis but also increased the activities of the enzymes affording the utilisation of glucose by insulin dependent pathways : it controlled phosphorylase levels , gluconeogenic enzymes and sorbitol dehydrogenase . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
39,
52
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
143,
150
]
} |
two kinships that were extensively studied and reported almost 20 years ago and used to show heterogeneity among kinships with peroneal muscular atrophy and to characterize hmsn i were investigated for linkage to various blood erythrocyte and lymphocyte ( hla ) antigens . | NA | {
"id": "C0007959",
"name": "peroneal muscular atrophy",
"pos": [
127,
152
]
} | {
"id": "C0027888",
"name": "hmsn i",
"pos": [
173,
179
]
} |
using this technique eleven crystallin fractions could be discerned : hm- , alpha- , three beta h- , two beta l- , beta s- and three gamma-crystallins . | NA | {
"id": "C0010422",
"name": "crystallin",
"pos": [
28,
38
]
} | {
"id": "C0017030",
"name": "gamma-crystallins",
"pos": [
133,
150
]
} |
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