text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the concentrations of the higher molecular weight crystallins ( hm- , alpha- and beta h-crystallin ) seem to increase with age while those of the lower molecular weight ( beta l- and gamma-crystallin ) decrease . | NA | {
"id": "C0010422",
"name": "crystallins",
"pos": [
50,
61
]
} | {
"id": "C0005203",
"name": "beta",
"pos": [
171,
175
]
} |
the concentrations of the higher molecular weight crystallins ( hm- , alpha- and beta h-crystallin ) seem to increase with age while those of the lower molecular weight ( beta l- and gamma-crystallin ) decrease . | NA | {
"id": "C0010422",
"name": "crystallins",
"pos": [
50,
61
]
} | {
"id": "C0017030",
"name": "gamma-crystallin",
"pos": [
183,
199
]
} |
the hypothesis that aging of articular chondrocytes at a cellular level results from loss of dna repair capability was studied by measuring unscheduled dna synthesis ( uds ) . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
39,
51
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
57,
65
]
} |
the intact antibiotics latamoxef , cephamandole , and cefoperazone , which contain the side chain , did not inhibit the reaction at concentrations up to 2 mmol/l . | NA | {
"id": "C0007541",
"name": "cephamandole",
"pos": [
35,
47
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
54,
66
]
} |
following a consequent outline of his communication , the author subsequently describes his experiences , the possibilities of managing and personal techniques available in case of operative problems or postoperative complications such as bleeding , haematoma , dermal necrosis or scar formation or infection . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
239,
247
]
} | {
"id": "C0018944",
"name": "haematoma",
"pos": [
250,
259
]
} |
despite the presence of recognizable somatotropes , the ectopic anterior pituitary does not appear to secrete significant amounts of gh , making the intact rat bearing multiple pituitary grafts an excellent model of chronic hyperprolactinemia . | NA | {
"id": "C0032016",
"name": "anterior",
"pos": [
64,
72
]
} | {
"id": "C0037663",
"name": "gh",
"pos": [
133,
135
]
} |
in ordinary hanks ' medium , theophylline and 3-isobutyl-1-methylxanthine ( ibmx ) dose-dependently inhibited the antigen-induced histamine release but these drugs were ineffective in ca2+-free medium . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
29,
41
]
} | {
"id": "C0000096",
"name": "3-isobutyl-1-methylxanthine",
"pos": [
46,
73
]
} |
thermodynamic complex formation constants are reported for the substrates 1-adamantaneamine ( amantadine ) , 1-adamantaneammonium ion , 1-adamantanemethylamine , 1-adamantane-methylammonium ion , 1-adamantanecarboxylic acid , 1-adamantane-carboxylate ion , 1-adamantaneacetic acid and 1-adamantaneacetate ion . | NA | {
"id": "C0002403",
"name": "amantadine",
"pos": [
94,
104
]
} | {
"id": "C0001392",
"name": "adamantane",
"pos": [
287,
297
]
} |
chronic continuous infusion of norepinephrine ( ne ) or epinephrine ( epi ) subcutaneously in rats resulted in rapid elevation of systolic blood pressure ( sbp ) by 40 mm hg . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
31,
45
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
56,
67
]
} |
the maternal serum concentrations of human chorionic gonadotropin , pregnancy-specific beta-l-glycoprotein , placental lactogen , progesterone , 17-hydroxyprogesterone , estradiol and estriol were measured in 13 women who smoked marijuana regularly throughout pregnancy . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
130,
142
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
145,
167
]
} |
of the total lipids synthesized from acac and glucose , respectively , phospholipid plus monoglyceride accounted for 64 % and 77 % , triglyceride 13 % and 13 % , diglyceride plus cholesterol 11 % and 4 % , fatty acids 9 % and 4 % , and cholesteryl esters 3 % and 1 % . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
179,
190
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
236,
254
]
} |
analysis of the lipoprotein profile showed that the excess of plasma cholesterol with the restricted cholesterol-rich diet corresponded to an increase in the concentration of very low density lipoprotein ( vldl ) and low density lipoproteins ( ldl ) without any additional changes in the composition of these lipoprotein... | NA | {
"id": "C0023825",
"name": "very low density lipoprotein",
"pos": [
175,
203
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
309,
321
]
} |
the increase in cholesterol turnover rate induced by the cholesterol-rich diet was accentuated by dietary restriction , whereas rabbits on standard restricted diet showed a slight decrease . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
16,
27
]
} | {
"id": "C0008395",
"name": "cholesterol",
"pos": [
57,
68
]
} |
the changes in fatty acid composition in the total lipid extract ( decreased palmitoleic , oleic and arachidonic acids and increased linoleic and docosahexaenoic acids ) from the diabetic animals were present in both the major phosphoglycerides , phosphatidylcholine and phosphatidylethanolamine , with very little chang... | NA | {
"id": "C0162448",
"name": "phosphoglycerides",
"pos": [
227,
244
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
247,
266
]
} |
the changes in fatty acid composition in the total lipid extract ( decreased palmitoleic , oleic and arachidonic acids and increased linoleic and docosahexaenoic acids ) from the diabetic animals were present in both the major phosphoglycerides , phosphatidylcholine and phosphatidylethanolamine , with very little chang... | NA | {
"id": "C0162448",
"name": "phosphoglycerides",
"pos": [
227,
244
]
} | {
"id": "C0031618",
"name": "phosphatidylethanolamine",
"pos": [
271,
295
]
} |
non-anthracite coal dusts containing sio2 crystalline phases ( alpha-quartz ) as an admixture -- exhibit fibrogenic effects on white rats ' lungs -- proportional to free silica content . | NA | {
"id": "C0034387",
"name": "quartz",
"pos": [
69,
75
]
} | {
"id": "C0037098",
"name": "silica",
"pos": [
170,
176
]
} |
the outward pathways of glycine from the total body free glycine pool are conversion to other amino acids and oxidation to excretory end products ( 30 % to 42 % ) and incorporation into protein , which accounts for 45 % to 61 % of glycine n loss from the metabolic pool . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
94,
99
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
231,
238
]
} |
these results indicate that the effect of chronic exercise on lipids and lipoproteins can be mimicked by acute prolonged exercise . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
62,
68
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
73,
85
]
} |
metabolism of pyruvate , branched-chain alpha-keto acids , acetoacetate and , to a lesser extent beta-hydroxybutyrate , were all inhibited by cyclopropane carboxylate . | NA | {
"id": "C0022618",
"name": "keto acids",
"pos": [
46,
56
]
} | {
"id": "C0000988",
"name": "acetoacetate",
"pos": [
59,
71
]
} |
despite the use of a wide variety of dose regimens and pretreatments , no recipient developed either insulitis , hyperglycemia , or glucose intolerance . | NA | {
"id": "C0020456",
"name": "hyperglycemia",
"pos": [
113,
126
]
} | {
"id": "C0271650",
"name": "glucose intolerance",
"pos": [
132,
151
]
} |
no dietary-induced changes were noted in either the fasting or postprandial values of glucose cholesterol , chylomicron-tg , low-density lipoprotein-cholesterol , high-density lipoprotein ( hdl ) -cholesterol , hdl2-cholesterol , or hdl3-cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
94,
105
]
} | {
"id": "C0023824",
"name": "low-density lipoprotein-cholesterol",
"pos": [
125,
160
]
} |
no dietary-induced changes were noted in either the fasting or postprandial values of glucose cholesterol , chylomicron-tg , low-density lipoprotein-cholesterol , high-density lipoprotein ( hdl ) -cholesterol , hdl2-cholesterol , or hdl3-cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
94,
105
]
} | {
"id": "C0023822",
"name": "high-density",
"pos": [
163,
175
]
} |
a mixture of glutamate , aspartate , and alanine at concentrations given in the hydrolysate reproduced the full amino acid effect . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
41,
48
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
112,
122
]
} |
our findings suggest that biochemical abnormalities associated with primary hyperparathyroidism , like hypercalcemia , hypophosphatemia , and elevated parathyroid hormone levels may cause and sustain a form of endogenous insulin resistance , which consequently leads to hyperinsulinemia and to impaired glucose tolerance... | NA | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
221,
239
]
} | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
270,
286
]
} |
the inhibiting activity of various human serum lipoprotein classes and their lipid components on the infectivity of rhabdoviruses has been studied . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
47,
58
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
77,
82
]
} |
four local anaesthetics ( las ) , amethocaine and procaine ( esters ) and cinchocaine and lignocaine ( amides ) have been assessed in terms of their ability to induce turbidity increases in non-growing cells of escherichia coli suspended in a carbohydrate free defined medium ( cfm ) or distilled water or in 0.2 m phosp... | NA | {
"id": "C0012050",
"name": "cinchocaine",
"pos": [
74,
85
]
} | {
"id": "C0002482",
"name": "amides",
"pos": [
103,
109
]
} |
the protection conferred by this factor was mainly cell mediated but immune serum enhanced this immunity despite the fact that no antibodies were detected in it . | NA | {
"id": "C0020960",
"name": "immune serum",
"pos": [
69,
81
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
130,
140
]
} |
the breath hydrogen test is a sensitive , non-invasive method for detecting sucrose malabsorption , whether due to a primary deficiency or secondary to other bowel disorders . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
84,
97
]
} | {
"id": "C0021831",
"name": "bowel disorders",
"pos": [
158,
173
]
} |
earlier findings indicated that several other cannabinoids in addition to delta 1-tetrahydro-cannabinol ( thc ) were able to stimulate the synthesis of prostaglandins in cell culture systems . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
46,
58
]
} | {
"id": "C0006865",
"name": "cannabinol",
"pos": [
93,
103
]
} |
molecular activities of a reconstituted aryl hydrocarbon hydroxylase ( ec 1.14.14.1 ) containing , respectively , cytochrome p-450i , p-450iia , and p-450iib were 0.224 , 0.250 , and 0.395 ( moles per minute per mole of cytochrome p-450 ) , and were estimated to be one-tenth that of cytochrome p-448 induced in rat live... | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
114,
130
]
} | {
"id": "C0003927",
"name": "aryl",
"pos": [
423,
427
]
} |
furthermore , similar peptide maps were obtained following digestion with alpha-chymotrypsin and papain , and each isozyme yielded a single immunoprecipitin band upon reaction with the immunoglobulin g fraction from rabbits immunized with the phenobarbital-induced enzyme . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
115,
122
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
265,
271
]
} |
four distinct classes of antibiotics , the aminoglycosides , tetracyclines , lincomycin-clindamycin , and peptides , were examined in intact bc3h-1 cells for their capacity to influence the relationship between agonist binding to the cholinergic receptor and the response elicited . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
77,
87
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
88,
99
]
} |
the most potent inhibitors were the peptides of the polymyxin-colistin class , which at submicromolar concentrations noncompetitively blocked agonist-elicited na+ permeability . | NA | {
"id": "C0032539",
"name": "polymyxin",
"pos": [
52,
61
]
} | {
"id": "C0009316",
"name": "colistin",
"pos": [
62,
70
]
} |
it is concluded that the pituitary dopamine receptors negatively coupled with an adenylate cyclase are the classical d2 receptors involved in prolactin secretion . | NA | {
"id": "C0034798",
"name": "dopamine receptors",
"pos": [
35,
53
]
} | {
"id": "C0058698",
"name": "d2 receptors",
"pos": [
117,
129
]
} |
since the phenothiazines have been implicated as anticalmodulin drugs and inhibit contractile activity in smooth muscle , we examined the effects of the phenothiazine , fluphenazine , on isometric tension development and phosphorylation of phosphorylase and the phosphorylatable light chain ( p-light chain ) of myosin i... | NA | {
"id": "C0031436",
"name": "phenothiazines",
"pos": [
10,
24
]
} | {
"id": "C0016368",
"name": "fluphenazine",
"pos": [
169,
181
]
} |
the relief of product inhibition of bp metabolism , the stimulation of the formation of bp 7,8-dihydrodiol-9,10-oxides ( de ) , and the corresponding dna adducts were all dependent to varying extents on dna concentration . | NA | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
150,
161
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
203,
206
]
} |
we have analyzed the responses of four different glucocorticoid-inducible proteins , tyrosine aminotransferase [ l-tyrosine:2-oxoglutarate aminotransferase ( ec 2.6.1.5 ) ] , glutamine synthetase [ l-glutamate : ammonia ligase ( ec 6.3.1.2 ) ] , a secreted glycoprotein belt i , and the mouse mammary tumor virus ( mmtv ... | NA | {
"id": "C0041487",
"name": "tyrosine aminotransferase",
"pos": [
85,
110
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
139,
155
]
} |
it disappears readily in the presence of very low concentrations ( ki less than 1 nm ) of benzomorphan opiates ( bremazocine , cyclazocine , and ethylketocyclazocine ) yet it is relatively insensitive to inhibition by mu- and delta-agonists . | NA | {
"id": "C0010526",
"name": "cyclazocine",
"pos": [
127,
138
]
} | {
"id": "C0079314",
"name": "ethylketocyclazocine",
"pos": [
145,
165
]
} |
equilibrium dialysis was used to test the ability of the dihydropyridines nitrendipine , felodipine , and nicardipine to inhibit the binding of [ 3h ] chlorpromazine , [ 14c ] pimozide , and 45ca2+ to calmodulin . | NA | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
57,
73
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
74,
86
]
} |
equilibrium dialysis was used to test the ability of the dihydropyridines nitrendipine , felodipine , and nicardipine to inhibit the binding of [ 3h ] chlorpromazine , [ 14c ] pimozide , and 45ca2+ to calmodulin . | NA | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
57,
73
]
} | {
"id": "C0015772",
"name": "felodipine",
"pos": [
89,
99
]
} |
at dihydropyridine concentrations near the limit of solubility ( 10 microm ) , the only significant effect in these three binding experiments was a 26 % inhibition of [ 14c ] pimozide binding to calmodulin by nicardipine , indicating that the dihydropyridines do not bind to the same site on calmodulin as chlorpromazine... | NA | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
209,
220
]
} | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
243,
259
]
} |
cytotoxicity , as measured by cell-plating efficiency , correlates linearly with the level of dna breakage induced by both agents ( hgcl2 , r = 0.97 ; x-rays , r = 0.99 ) , although a substantial difference in axis intercepts of the two linear regression lines indicates that a higher level of dna damage was required by... | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
94,
97
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
370,
371
]
} |
analysis of the dna sequences of the 5 ' end of the clones demonstrated that although beta- and gamma-actin genes start with a methionine codon ( met-asp-asp-asp and met-glu-glu-glu , respectively ) , the alpha-actin gene starts with a methionine codon followed by a cysteine codon ( met-cys-asp-glu-asp-glu ) . | NA | {
"id": "C0242610",
"name": "starts",
"pos": [
222,
228
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
276,
281
]
} |
human peripheral blood mononuclear cells were isolated on a large scale by leukapheresis of either individual donors or pooled cell concentrates supplied by a local blood bank . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
6,
40
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
127,
131
]
} |
based on the sensitivity of the assays employed , these results indicate the complement-mediated membrane damage is not enhanced by covalent breakdown of membrane phospholipids , but is entirely caused by physical action of the membrane attack complex . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
77,
87
]
} | {
"id": "C0009545",
"name": "membrane attack complex",
"pos": [
228,
251
]
} |
immunodiffusion showed that 50 k lacked some of the cea epitopes , and that normal spleen contained an antigen identical to 50 k . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
56,
64
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
103,
110
]
} |
these results suggest that the observed affinity of complex mixtures of antibody for antigens containing multiple epitopes calculated from scatchard plots may not be related to the affinity or avidity of any of the antibody species for a given epitope . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
85,
93
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
244,
251
]
} |
an antiserum to s. mutans mt573 ( serotype e ) contained antibody predominantly to lta , whereas , anti-s. mutans mt703 ( serotype e ) reacted with both dextran and lta ; | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
3,
12
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
57,
65
]
} |
irradiation at 4.4 j/m2 caused a transient increase in the number of cells synthesizing dna and a decrease in the rate of dna synthesis relative to mock-irradiated controls . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
88,
91
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
159,
160
]
} |
we previously developed a quantitative assay for measuring the induction of ouabain-resistant ( ouar ) variants in transformable c3h/20t1/2 cl 8 mouse fibroblasts following treatment of the cells with chemical carcinogens . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
151,
162
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
190,
195
]
} |
these studies show that both spontaneous and chemically induced high level ouar phenotypes of c3h/10t1/2 cl 8 mouse fibroblasts can be transferred via microcell-mediated chromosome transfer , and provide strong genetic evidence that chemically induced ouar phenotypes of c3h/10t1/2 cl 8 cells arise from mutations at oua... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
116,
127
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
287,
292
]
} |
the present results do not indicate that hepatocytes take an 'intermediate ' position between existing in vitro and in vivo activation systems , although they do suggest that these mouse hepatocyte preparations activate the nitrosamines dmna and mena in a quantitatively or qualitatively different way than do mouse-live... | NA | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
224,
236
]
} | {
"id": "C0012431",
"name": "dmna",
"pos": [
237,
241
]
} |
these results are direct evidence that benzo [ alpha ] pyrene adducts in dna are acted upon by the same repair enzyme as those that handle uv-induced lesions in dna . | NA | {
"id": "C0242958",
"name": "adducts",
"pos": [
62,
69
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
161,
164
]
} |
several monoclonal antibodies ( mcabs ) elicited against the nicotinic acetylcholine receptor ( achr ) from torpedo react also with skeletal muscle achr . | NA | {
"id": "C0034830",
"name": "nicotinic",
"pos": [
61,
70
]
} | {
"id": "C0034792",
"name": "achr",
"pos": [
148,
152
]
} |
effects of leukocyte interferon on clinical symptoms and hormone levels in patients with mid-gut carcinoid tumors and carcinoid syndrome . | NA | {
"id": "C0007095",
"name": "carcinoid tumors",
"pos": [
97,
113
]
} | {
"id": "C0024586",
"name": "carcinoid syndrome",
"pos": [
118,
136
]
} |
in this dna lesion , the glutamine codon cag at the beta 39 position is mutated to tag , which results in a stop codon and premature termination of the beta-globin chain . | NA | {
"id": "C0009221",
"name": "codon",
"pos": [
35,
40
]
} | {
"id": "C0242611",
"name": "stop codon",
"pos": [
108,
118
]
} |
hla-d region beta-chain dna endonuclease fragments differ between hla-dr identical healthy and insulin-dependent diabetic individuals . | NA | {
"id": "C0019754",
"name": "hla-d",
"pos": [
0,
5
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
66,
72
]
} |
we have previously shown that a fraction from the nuclei of s phase ( dna-synthesizing ) chinese hamster embryo fibroblasts ( chef/18 cells ) can be obtained that has a number of the enzyme activities required for dna biosynthesis , and can catalyse the incorporation of labelled precursors into dna ( refs 1-4 , also se... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
112,
123
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
134,
139
]
} |
the thyroid mrna encodes a precursor to the hormone calcitonin whereas that in neural tissues generates a novel neuropeptide , referred to as calcitonin gene-related peptide ( cgrp ) . | NA | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
52,
62
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
112,
124
]
} |
the thyroid mrna encodes a precursor to the hormone calcitonin whereas that in neural tissues generates a novel neuropeptide , referred to as calcitonin gene-related peptide ( cgrp ) . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
112,
124
]
} | {
"id": "C0006669",
"name": "calcitonin gene-related peptide",
"pos": [
142,
173
]
} |
in autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus ( sle ) , autoantibodies are generated against a variety of macromolecules . | NA | {
"id": "C0004364",
"name": "autoimmune disorders",
"pos": [
3,
23
]
} | {
"id": "C0024141",
"name": "systemic lupus",
"pos": [
57,
71
]
} |
the distribution , metabolism and elimination into the urine of ( 14c ) -tetrahydronorharmane ( thn ) as well as of ( 14c ) -6-hydroxy-tetrahydronorharmane ( 6-oh-thn ) are investigated in female and male rats . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
19,
29
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
34,
45
]
} |
activated complement and anaphylatoxins increase the in vitro production of prostacyclin by rabbit aorta endothelium . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
10,
20
]
} | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
25,
39
]
} |
the effect of activated human serum complement and highly purified anaphylatoxins on the production of prostacyclin ( pgi2 ) by endothelium of the isolated rabbit aorta was investigated . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
36,
46
]
} | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
67,
81
]
} |
the results indicated that complement activation with endotoxin ( lps ) or cobra venom factor ( cvf ) led to the generation of principles that stimulated pgi2 formation . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
54,
63
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
66,
69
]
} |
muscimol , gaba and ( +/- ) -baclofen bound in vitro to these gaba sites with ic50 , 44 , 49 and 431 nm respectively . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
29,
37
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
62,
66
]
} |
however the degree of alpha 1-adrenoceptor selectivity differs from each enantiomer , and the enantiomeric activity ratios differ for each alpha-adrenoceptor subtype . | NA | {
"id": "C0001638",
"name": "alpha 1-adrenoceptor",
"pos": [
22,
42
]
} | {
"id": "C0034784",
"name": "alpha-adrenoceptor",
"pos": [
139,
157
]
} |
the areas were superfused with artificial csf and the release of the endogenous catecholamines dopamine , noradrenaline and adrenaline was determined in the superfusates . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
106,
119
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
124,
134
]
} |
it was observed that at low bp concentrations selectively cells with fibroblasts morphology were intensely stained for ggt . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
58,
63
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
69,
80
]
} |
at relatively higher concentrations of bp all the cells with fibroblasts morphology were eliminated and ggt positive areas were observed in cells with epithelial cell morphology . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
61,
72
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
140,
145
]
} |
cholesterol , cholesteryl esters , free fatty acids and triacylglycerols were found in the fraction of neutral lipids . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
0,
11
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
14,
32
]
} |
the isolated antibodies from the 21s cic and the eluate showed restricted reactivity against autologous aml cells . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
13,
23
]
} | {
"id": "C0003313",
"name": "cic",
"pos": [
37,
40
]
} |
to further clarify the mechanism of the suppressed responses to mitogens , pbmc or nonphagocytic cells from uremic patients were cocultured with control t cells in the presence of pha , or the effects of adherent cells from uremic patients on pha responses of autologous or allogeneic control t cells were studied . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
75,
79
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
189,
192
]
} |
hepatic cytosolic aldehyde dehydrogenase ( aldh ) of 14 day old neonates maintained on et was increased from water controls without a concomitant change in specific activities of mitochondrial aldh or or liver alcohol dehydrogenase ( adh ) . | NA | {
"id": "C0001985",
"name": "aldehyde dehydrogenase",
"pos": [
18,
40
]
} | {
"id": "C2827577",
"name": "mitochondrial aldh",
"pos": [
179,
197
]
} |
this study suggests ( 1 ) the n-terminal amino acids of ang ii are important for the acth stimulatory action of ang ii , ( 2 ) [ sar1 , ala8 ] ang ii and [ sar1 , gly8 ] ang ii are specific ang ii antagonists at the pituitary level towards the acth releasing effect of ang ii , and ( 3 ) corticosterone inhibits the in v... | NA | {
"id": "C0003018",
"name": "ang ii",
"pos": [
56,
62
]
} | {
"id": "C0003009",
"name": "ang ii",
"pos": [
351,
357
]
} |
stereo depth electroencephalography ( eeg ) is of proven benefit in lateralizing and localizing seizure origin in select cases of epilepsy . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
96,
103
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
130,
138
]
} |
the distribution of the neuropeptides vasoactive intestinal polypeptide , cholecystokinin octapeptide , substance p , neurotensin , methionine-enkephalin and somatostatin has been mapped immunocytochemically in the bed nucleus of the stria terminalis , one of the major sites of termination for efferent projections from... | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
24,
37
]
} | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
118,
129
]
} |
the recorded potentials were lower in the eyes with silicone oil compared to those in which the retinas were reattached without silicone . | NA | {
"id": "C0037111",
"name": "silicone oil",
"pos": [
52,
64
]
} | {
"id": "C0037114",
"name": "silicone",
"pos": [
128,
136
]
} |
the occurrence of crossreacting antibodies in both anti-suscept and anti-resist antisera further suggests that mimicked haemolymph-like antigens include at least some which are common to both snail stocks . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
32,
42
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
80,
88
]
} |
the composition and the pathway of the different lipoprotein classes ( chylomicrons , vldl , ldl , hdl ) are reviewed , as also the main pathological perturbations that attack them . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
49,
60
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
71,
83
]
} |
the authors present a historical review of the epidemiologic and pathophysiologic data which have supported the relations between the clinical complications of atherosclerosis on one hand , plasma lipids ( cholesterol and triglycerides ) , lipoproteins ( on electrophoretic basis ) , lipoproteins lipids ( separated by u... | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
240,
252
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
297,
303
]
} |
at the time children with suspected hypopituitarism are seen with a subnormal growth rate , it is expected that testing will demonstrate growth hormone ( hgh ) deficiency . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
137,
151
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
154,
157
]
} |
results indicated that patients with cancer pain appear to be similar in terms of intensity of the pain and the kind of pain which they experience with respect to sensory , affective , and evaluative qualities . | NA | {
"id": "C0596240",
"name": "cancer pain",
"pos": [
37,
48
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
120,
124
]
} |
the value of urinary pregnanediol determinations as an indication for the use of progesterone in the treatment of threatened abortion . | NA | {
"id": "C0033004",
"name": "pregnanediol",
"pos": [
21,
33
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
81,
93
]
} |
[ liver diseases in children , with special reference to epidemic hepatitis and the tropical diseases of the liver ] . | NA | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
66,
75
]
} | {
"id": "C0023895",
"name": "the",
"pos": [
105,
108
]
} |
the most marked hyperproteinemias which developed were caused principally by increases in the host 's own globulin and to a lesser extent by the presence of foreign protein in the circulation . | NA | {
"id": "C0017649",
"name": "globulin",
"pos": [
106,
114
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
165,
172
]
} |
the effects of epinephrine , norepinephrine , and acetylcholine on the electrogram of the isolated frog heart . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
15,
26
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
29,
43
]
} |
the results of the study suggested that the average size of the reactions is related to the prevalence in the past of tuberculosis in cattle , and this was again the case in the analysis of the campaign material : smaller reactions were found in counties long free of cattle tuberculosis , larger reactions in counties w... | NA | {
"id": "C0041296",
"name": "tuberculosis",
"pos": [
118,
130
]
} | {
"id": "C0041307",
"name": "in",
"pos": [
332,
334
]
} |
the present report , while regarded as preliminary , has possible implications for tuberculosis control studies in countries where very little is known about the prevalence of bovine tuberculosis . | NA | {
"id": "C0041296",
"name": "tuberculosis",
"pos": [
83,
95
]
} | {
"id": "C0041307",
"name": "bovine",
"pos": [
176,
182
]
} |
the determination of iodide-iodate activity in sodium radio-iodide ( i131 ) by automatic scanning of paper chromatograms . | NA | {
"id": "C0021966",
"name": "iodide",
"pos": [
21,
27
]
} | {
"id": "C0037521",
"name": "sodium",
"pos": [
47,
53
]
} |
phosphoglucomutase , hexose isomerase , and a phosphatase for fructose-1,6-diphosphate also appear to be present in arbacia eggs . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
21,
27
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
62,
70
]
} |
the rate of appearance of the non-virus proteins in newly infected cultured leaf tissue at various times after inoculation has been determined by immunochemical techniques and by direct isolation of the proteins . | NA | {
"id": "C0042736",
"name": "virus proteins",
"pos": [
34,
48
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
203,
211
]
} |
it is likely that one or more of these proteins represents small protein units which occur in the tmv nucleoprotein.as they exist in the infected leaf , the non-virus proteins are probably no longer available to the biochemical processes which lead to tmv synthesis . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
39,
47
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
102,
115
]
} |
net protein value of blood fibrin for the albino rat : evaluation of nitrogen balance and carcass analysis methods . | NA | {
"id": "C0005832",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
27,
33
]
} |
a procedure for estimating the racemisation of adrenaline or noradrenaline in dilute solution by means of an ion exchanger . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
47,
57
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
61,
74
]
} |
[ two cases of superacute meningococcal purpura resembling clinically the purpura fulminans , treated by cortisone and cured ] . | NA | {
"id": "C0034150",
"name": "purpura",
"pos": [
40,
47
]
} | {
"id": "C0085650",
"name": "purpura",
"pos": [
74,
81
]
} |
[ clinico-biological study of infantile liver diseases with special reference to minor hepatic insufficiency in children ] . | NA | {
"id": "C0023895",
"name": "of",
"pos": [
27,
29
]
} | {
"id": "C1306571",
"name": "hepatic insufficiency",
"pos": [
87,
108
]
} |
[ cysts of the ascending mandibular ramus , with comments on the differential diagnosis between cysts and tumors resembling cysts ] . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
106,
112
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
124,
129
]
} |
pyridoxal phosphate as the coenzyme of the mammalian decarboxylase for l-cysteine sulphinic and l-cysteic acids . | NA | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
0,
19
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
27,
35
]
} |
[ cancer , tobacco , wine and alcohol ; analysis of their influence , if such should be the case ] . | NA | {
"id": "C0043188",
"name": "wine",
"pos": [
21,
25
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
30,
37
]
} |
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