text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
amino acid studies in the transformation of proteins of the hen 's egg to tissue proteins during incubation . | NA | {
"id": "C0013700",
"name": "proteins",
"pos": [
44,
52
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
81,
89
]
} |
oxygen dissociation curves in sickle cell anemia and in subjects with the sickle cell trait . | NA | {
"id": "C0002895",
"name": "sickle cell anemia",
"pos": [
30,
48
]
} | {
"id": "C0037054",
"name": "sickle",
"pos": [
74,
80
]
} |
the formation of lysine and glutamic acid decarboxylases was not enhanced by an increased acidity during growth while increased oxygen tension was inhibitory to amino acid decarboxylase synthesis in these fecal cultures . | NA | {
"id": "C0017785",
"name": "glutamic acid decarboxylases",
"pos": [
28,
56
]
} | {
"id": "C0007054",
"name": "decarboxylase",
"pos": [
172,
185
]
} |
comparative clinical and electrocyclic observations on twin brothers concordant as to schizophrenia , with periodic manifestations of folie a deux phenomena . | NA | {
"id": "C0036341",
"name": "schizophrenia",
"pos": [
86,
99
]
} | {
"id": "C0036939",
"name": "folie a deux",
"pos": [
134,
146
]
} |
control of bilharziasis : a simple device for measuring copper concentration in natural waters treated with copper sulphate . | NA | {
"id": "C0009968",
"name": "copper",
"pos": [
56,
62
]
} | {
"id": "C0056301",
"name": "copper sulphate",
"pos": [
108,
123
]
} |
[ three cases of successful surgery of aortic coarctation with other congenital malformations of the heart ] . | NA | {
"id": "C0003492",
"name": "of",
"pos": [
14,
16
]
} | {
"id": "C0018798",
"name": "congenital",
"pos": [
69,
79
]
} |
[ penicillin v ( phenoxymethylpenicillin a peroral acid resistant penicillin ; comparative studies on blood levels following oral administration of penicillin v and g ] . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
2,
12
]
} | {
"id": "C0030840",
"name": "penicillin",
"pos": [
148,
158
]
} |
[ medical therapy in the treatment of various types of stuttering ; an attempt to systematize speech disorders ] . | NA | {
"id": "C0038506",
"name": "stuttering",
"pos": [
55,
65
]
} | {
"id": "C0037822",
"name": "speech disorders",
"pos": [
94,
110
]
} |
[ excretion of free corticoids in urine of scorbutic guinea pigs in relation to the excretion of 17-ketosteroids ] . | NA | {
"id": "C0001617",
"name": "corticoids",
"pos": [
20,
30
]
} | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
97,
112
]
} |
[ fixation of lime in aqueous medium by synthetic calcium phosphates having an apatite structure ( pseudoapatites ) ] . | NA | {
"id": "C0006712",
"name": "calcium phosphates",
"pos": [
50,
68
]
} | {
"id": "C0003522",
"name": "apatite",
"pos": [
105,
112
]
} |
[ effect of external temperature and of various quantities of dietary proteins on body weight and on certain indices of liver metabolism and their relation to the problem of optimal protein content in food ] . | NA | {
"id": "C0012177",
"name": "dietary proteins",
"pos": [
62,
78
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
182,
189
]
} |
both osteoblasts and osteoclasts were recovered in aspirated bone marrow material in other instances of metabolic bone diseases associated with increased bone repair and bone resorption-in hyperparathyroidism , osteoblastic malignant lesions , rickets , hemolytic anemia in children , and in normal infants in the growth... | NA | {
"id": "C0005944",
"name": "of metabolic bone diseases",
"pos": [
101,
127
]
} | {
"id": "C0035579",
"name": "rickets",
"pos": [
244,
251
]
} |
since there is a relatively high incidence of malignant diseases on the soles of the feet and the genitalia , routine removal of nevi developing in those areas is recommended . `` `` juvenile melanomas '' '' are active , cellular nevi occurring in prepubertal children . | NA | {
"id": "C0027960",
"name": "nevi",
"pos": [
129,
133
]
} | {
"id": "C0206737",
"name": ", cellular ne",
"pos": [
219,
232
]
} |
immunodiagnosis and chemotherapy of clonorchiasis sinensis , with especial reference to efficacy of chloroquine including a note on negative effect of oxychloroquine . | NA | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
100,
111
]
} | {
"id": "C0020336",
"name": "oxychloroquine",
"pos": [
151,
165
]
} |
the fast green stain of alfert and geschwind for nuclear basic protein is shown to obey the beer-lambert laws when used on purified histone . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
49,
56
]
} | {
"id": "C0019652",
"name": "histone",
"pos": [
132,
139
]
} |
the removal of fluorine from dilute solutions of sodium fluoride and stannous fluoride by powdered dental enamel . | NA | {
"id": "C0016327",
"name": "fluorine",
"pos": [
15,
23
]
} | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
49,
64
]
} |
stimulation of the sweat glands in the hairy skin of the dog by adrenaline , noradrenaline , acetylcholine , mecholyl and pilocarpine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
64,
74
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
77,
90
]
} |
[ response of neurogenic adrenaline and arterenol dilatation of vessels of skeletal muscles to novocaine , atropine and physostigmine , with a contribution to the problem of existence of vasodilatating nerves ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
25,
35
]
} | {
"id": "C0028351",
"name": "arterenol",
"pos": [
40,
49
]
} |
[ the knowledge of washable oil-in-water ointments . 7. studies on the effect of oil-water emulsifier on diffusion capacity of water from washable ointments ] . | NA | {
"id": "C0991882",
"name": "oil-in-water ointments",
"pos": [
28,
50
]
} | {
"id": "C1875574",
"name": "oil-water",
"pos": [
81,
90
]
} |
twenty patients with advanced malignant melanoma refractory to conventional chemotherapy , were entered into a phase ii study of epirubicin , one of the new doxorubicin analogues . | NA | {
"id": "C0014582",
"name": "epirubicin",
"pos": [
129,
139
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
157,
168
]
} |
mitoxantrone ( 1,4-dihydroxy-5,8-bis [ 2- [ ( 2-hydroxyethyl ) amino ] ethyl ) amino ) -9 , 10 anthracenedione dihydrochloride , nsc 301,739 ) is a new aminoanthraquinone derivative with clinical activity in the treatment of advanced breast cancer ( 1 , 2 ) , lymphoma ( 3 ) , and acute leukemia ( 4 ) . | NA | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
0,
12
]
} | {
"id": "C0003174",
"name": "anthracenedione",
"pos": [
95,
110
]
} |
idarubicin ( idr ) is a new analog of daunorubicin ( dnr ) selected for clinical trials because of its outstanding activity in experimental leukemias of mice and in several experimental models when compared to dnr and doxorubicin . | NA | {
"id": "C0020789",
"name": "idarubicin",
"pos": [
0,
10
]
} | {
"id": "C0011015",
"name": "dnr",
"pos": [
210,
213
]
} |
idarubicin ( idr ) is a new analog of daunorubicin ( dnr ) selected for clinical trials because of its outstanding activity in experimental leukemias of mice and in several experimental models when compared to dnr and doxorubicin . | NA | {
"id": "C0011015",
"name": "dnr",
"pos": [
53,
56
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
218,
229
]
} |
twenty-three patients with metastatic colorectal carcinoma were treated with 4'-epi-doxorubicin ( epirubicin , 4'-epi-dx ) 90 mg/m2 i.v . every 4 weeks . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
84,
95
]
} | {
"id": "C0014582",
"name": "4",
"pos": [
144,
145
]
} |
although certain antigens ( epitopes ) are destroyed in the procedure , it appears that about two-thirds of the polypeptides retain antigenicity . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
17,
25
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
28,
36
]
} |
we have investigated a number of enzymes contributing to hypoxanthine production in ureaplasma urealyticum , as part of an ongoing effort to identify a comparative profile of isozyme activities in this species . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
33,
40
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
175,
182
]
} |
there was no significant difference in body weight , but at 7 days the mean bursa to body weight ratio of infected birds was significantly less ( p less than 0.01 ) than that of the control birds and microscopic changes were seen in some bursae . | NA | {
"id": "C0005911",
"name": "difference",
"pos": [
25,
35
]
} | {
"id": "C0005910",
"name": "body",
"pos": [
85,
89
]
} |
restriction endonuclease-digested dnas of the organisms were hybridized with nick-translated probes consisting of defined portions of the rrnb rrna operon of escherichia coli and with a recombinant plasmid pmc5 constructed of pbr325 and an insert containing m. capricolum genes for 23s , 5s and most of the 16s rrna gene... | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
143,
147
]
} | {
"id": "C0035702",
"name": "16s rrna",
"pos": [
307,
315
]
} |
host dna has been digested with restriction enzymes , and recombinant dna clones of ai fragments in coliphage m13 vectors have been used as probes to detect viral dna sequences integrated into spiroplasmas . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
5,
8
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
157,
166
]
} |
thus , to a first approximation , membrane lipid order in the liquid-crystalline state is directly proportional , and membrane lipid fluidity inversely proportional , to the gel to liquid-crystalline phase transition temperature . | NA | {
"id": "C0025249",
"name": "membrane lipid",
"pos": [
34,
48
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
127,
132
]
} |
the lactoperoxidase-mediated radioiodination applied to study the transbilayer distribution of phosphatidylcholine ( pc ) in the membranes revealed that the pc in cells grown with dopc is almost equally distributed in the outer and inner leaflets of m. gallisepticum membranes , while the pc in dppc-grown cells is prefe... | NA | {
"id": "C0000039",
"name": "dppc",
"pos": [
295,
299
]
} | {
"id": "C1959616",
"name": "egg-pc",
"pos": [
371,
377
]
} |
blood glucose and plasma insulin responses to the meal with mashed potatoes were greater than to that with polished rice ( p less than 0.01 ) , which also produced a greater glucose response than that with white beans ( p less than 0.01 ) . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
0,
13
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
174,
181
]
} |
the specificities detected by these sublines included : ( a ) a specificity found on a subset of cells positive for drw6 which was inhibited by monoclonal antibodies against ds ( dc ) , the human homologue of the murine ia-encoded molecules , ( b ) another drw6-associated specificity blocked by an mt2-like antibody , a... | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
308,
316
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
364,
385
]
} |
these results show that more than one ie-like , as well as the ds/dc ( ia-like ) molecules , carry distinctive antigenic epitopes that can be recognized by allogeneic t cells . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
111,
120
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
121,
129
]
} |
the relative proportions of the newly synthesized glycosaminoglycans , including the low amounts of heparin , are similar to those found in isolation of endogenous lung glycosaminoglycans . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
100,
107
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
169,
187
]
} |
besides diarrhea , the chief finding was a nephrotic-like syndrome , in that there was edema , hypoproteinemia , and proteinuria . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
29,
36
]
} | {
"id": "C0013604",
"name": "edema",
"pos": [
87,
92
]
} |
the addition of nongerminal cells such as lymphocytes and fibroblasts were also not effective in stimulating abp secretion . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
58,
69
]
} |
resting cell studies demonstrated that 14c-labeled valine , threonine , leucine , isoleucine and alanine , but not lysine , were efficiently incorporated into protylonolide , indicating that these amino acids are metabolized to lower fatty acids . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
97,
104
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
197,
208
]
} |
the in vitro synergism of ps-5 combined with various penicillins and cephalosporins in antimicrobial activity was examined in detail against beta-lactam-resistant gram-negative bacteria . | NA | {
"id": "C0030842",
"name": "penicillins",
"pos": [
53,
64
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
141,
152
]
} |
introduction of a hydroxyl group into the thiazole ring nitrogen of cephalosporins belonging to the cefotiam and cefotaxime families gave rise to products , better described by the tautomeric n-oxide form , which proved particularly active against gram-negative bacteria . | NA | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
100,
108
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
113,
123
]
} |
intralitter variation in birth weight and total litter weight tended to be increased by folic acid administration . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
25,
37
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
55,
61
]
} |
litter size and weight at birth , litter size and weight at 42 d and pig survival to 42 d were analyzed . | NA | {
"id": "C0005612",
"name": "weight",
"pos": [
16,
22
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
50,
56
]
} |
there were significant differences in litter weight born and differences that approached significance ( p less than .10 ) for litter size at 42 d and litter weight at 21 d . | NA | {
"id": "C0005911",
"name": "differences",
"pos": [
23,
34
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
157,
163
]
} |
the traits studied were : number farrowed ( nb ) , litter birth weight ( lbwt ) , average pig birth weight ( bwt ) , litter size at 21 d ( n21 ) , litter weight at 21 d ( l21wt ) and average pig weight at 21 d ( wt21 ) . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
58,
70
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
195,
201
]
} |
most of the evidence points to the involvement of two families of neuropeptides in the control of feed intake in sheep : the opioid peptides , which include enkephalins , endorphins and dynorphins , and cholecystokinin ( cck ) peptides , of which cck-8 is the primary brain form . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
66,
79
]
} | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
125,
140
]
} |
most of the evidence points to the involvement of two families of neuropeptides in the control of feed intake in sheep : the opioid peptides , which include enkephalins , endorphins and dynorphins , and cholecystokinin ( cck ) peptides , of which cck-8 is the primary brain form . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
125,
140
]
} | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
157,
168
]
} |
most of the evidence points to the involvement of two families of neuropeptides in the control of feed intake in sheep : the opioid peptides , which include enkephalins , endorphins and dynorphins , and cholecystokinin ( cck ) peptides , of which cck-8 is the primary brain form . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
125,
140
]
} | {
"id": "C0014242",
"name": "endorphins",
"pos": [
171,
181
]
} |
most of the evidence points to the involvement of two families of neuropeptides in the control of feed intake in sheep : the opioid peptides , which include enkephalins , endorphins and dynorphins , and cholecystokinin ( cck ) peptides , of which cck-8 is the primary brain form . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
125,
140
]
} | {
"id": "C0013355",
"name": "dynorphins",
"pos": [
186,
196
]
} |
mutation to high level resistance to nitrofurantoin of a strain of escherichia coli carrying an r-plasmid conferring resistance to gentamicin , kanamycin and other antibiotics resulted in greatly increased resistance to the two aminoglycosides but not the other antibiotics . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
131,
141
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
228,
243
]
} |
mutation to high level resistance to nitrofurantoin of a strain of escherichia coli carrying an r-plasmid conferring resistance to gentamicin , kanamycin and other antibiotics resulted in greatly increased resistance to the two aminoglycosides but not the other antibiotics . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
144,
153
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
228,
243
]
} |
during acute incubations , luteinizing hormone provoked rapid and concentration-dependent increases in the incorporation of 32po4 into phosphatidic acid , phosphatidylinositol , and the polyphosphoinositides . | NA | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
155,
175
]
} | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
186,
207
]
} |
similarly , luteinizing hormone provoked increases in labeling of phosphatidylinositol and the polyphosphoinositides when granulosa cells were incubated with myo- [ 2-3h ] inositol . | NA | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
66,
86
]
} | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
95,
116
]
} |
these results demonstrate that : ( a ) luteinizing hormone has selective effects on phospholipid metabolism in rat granulosa cells which involve phosphatidic acid , phosphatidylinositol , and the polyphosphoinositides , ( b ) luteinizing hormone increases net levels of phosphatidylinositol and presumably phosphatidic a... | NA | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
165,
185
]
} | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
332,
353
]
} |
first , canine chylomicron remnants , which contained apo-b48 as their primary apoprotein constituent , were generated by the hydrolysis of chylomicrons with milk lipoprotein lipase . | NA | {
"id": "C0443616",
"name": "chylomicron remnants",
"pos": [
15,
35
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
140,
152
]
} |
the configuration bears sufficient similarity to that of protoporphyrin ix so that a common nomenclature may be used ( smith k. m. ( ed ) ( 1975 ) porphyrins and metalloporphyrins , pp . 3-5 , elsevier/north-holland biomedical press , amsterdam ) . | NA | {
"id": "C0033733",
"name": "protoporphyrin ix",
"pos": [
57,
74
]
} | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
169,
179
]
} |
the configuration bears sufficient similarity to that of protoporphyrin ix so that a common nomenclature may be used ( smith k. m. ( ed ) ( 1975 ) porphyrins and metalloporphyrins , pp . 3-5 , elsevier/north-holland biomedical press , amsterdam ) . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
147,
157
]
} | {
"id": "C0025541",
"name": "metalloporphyrins",
"pos": [
162,
179
]
} |
inhibition of the serine proteases leukocyte elastase , pancreatic elastase , cathepsin g , and chymotrypsin by peptide boronic acids . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
18,
34
]
} | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
56,
75
]
} |
inhibition of the serine proteases leukocyte elastase , pancreatic elastase , cathepsin g , and chymotrypsin by peptide boronic acids . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
18,
34
]
} | {
"id": "C0008742",
"name": "chymotrypsin",
"pos": [
96,
108
]
} |
inhibition of the serine proteases leukocyte elastase , pancreatic elastase , cathepsin g , and chymotrypsin by peptide boronic acids . | NA | {
"id": "C0064833",
"name": "leukocyte elastase",
"pos": [
35,
53
]
} | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
56,
75
]
} |
this type of inhibition has not been observed previously for synthetic inhibitors or serine proteases and in this study it was observed only for peptide boronic acids which satisfy the primary specificity requirements of the protease . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
85,
101
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
225,
233
]
} |
the initial trimming of glucosyl and mannosyl units from the high-mannose oligosaccharides of the hcg precursors occurred more rapidly for free alpha and cg-alpha than for free beta and cg-beta . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
98,
101
]
} | {
"id": "C0017963",
"name": "cg-alpha",
"pos": [
154,
162
]
} |
the initial trimming of glucosyl and mannosyl units from the high-mannose oligosaccharides of the hcg precursors occurred more rapidly for free alpha and cg-alpha than for free beta and cg-beta . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
98,
101
]
} | {
"id": "C0106132",
"name": "cg-beta",
"pos": [
186,
193
]
} |
the branch specificity of bovine colostrum and calf thymus udp-gal : n-acetylglucosaminide beta-1 -- -- 4-galactosyltransferase toward several branched oligosaccharides , which form part of the complex-type n-glycans of glycoproteins , was investigated . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
152,
168
]
} | {
"id": "C0032594",
"name": "glycans",
"pos": [
209,
216
]
} |
this effect is not produced by insulin , trypsin inhibitor , lysozyme , ribonuclease , myoglobin , cytochrome c , ovalbumin , or bovine albumin . | NA | {
"id": "C0029923",
"name": "ovalbumin",
"pos": [
114,
123
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
136,
143
]
} |
the change in the rate of formation of 3h2o from [ 5-3h ] glucose was slower to develop ( commencing at approximately 30 s ) than changes in cyclic amp concentration , hexose-6-p concentration , and the phosphorylase a/ ( a + b ) ratio which were maximal at 24 s . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
58,
65
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
168,
174
]
} |
epinephrine plus propranolol ( alpha-adrenergic combination ) treatment of the perfused heart also led to increases in glucose uptake , detritiation of [ 5-3h ] glucose , and the formation of lactate , but these occurred without significant changes in cyclic amp concentration , hexose-6-p concentration , or the phospho... | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
119,
126
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
279,
285
]
} |
fluorescence intensity of these enzyme species and the amount of phosphoenzyme permitted the simulation using the reaction mechanism including enzyme-atp complex , adp-sensitive phosphoenzyme , k+-sensitive phosphoenzyme , and k+-bound enzyme . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
32,
38
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
236,
242
]
} |
the concentration of insulin required for 50 % inhibition was 2-5 pm , whereas approximately 200 pm of proinsulin was required to achieve the same inhibition of transcription . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
21,
28
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
103,
113
]
} |
to investigate the basis for the preferential incorporation of apo-b and apo-ii into nascent vldl , the relative affinities of the apoproteins for vldl were compared by measuring their capacities to transfer from vldl into other lipoprotein or nonlipoprotein density classes . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
93,
97
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
247,
258
]
} |
culture medium containing [ 3h ] leucine-labeled vldl was incubated with plasma deficient in lipoproteins of rho less than 1.006 g/ml . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
49,
53
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
93,
105
]
} |
adp-ribosylation of gi alpha , in the presence of g beta gamma and photolyzed ( but not dark ) rhodopsin was increased by guanosine 5'-o- ( 2-thiodiphosphate ) or gdp , but not by ( beta , gamma-methylene ) guanosine triphosphate or guanosine 5'-o- ( 3-thiotriphosphate ) . | NA | {
"id": "C0018353",
"name": "guanosine triphosphate",
"pos": [
207,
229
]
} | {
"id": "C0079469",
"name": "guanosine 5",
"pos": [
233,
244
]
} |
the stimulatory and inhibitory regulatory components of adenylyl cyclase ( ns and ni ) , purified to apparent homogeneity without the use of regulatory ligands such as mg , naf , and guanyl-5'-yl imidodiphosphate , were tested for gtpase activity by incubating them with [ gamma-32p ] gtp and measuring 32pi liberation u... | NA | {
"id": "C0018366",
"name": "guanyl-5",
"pos": [
183,
191
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
285,
288
]
} |
isotopic dilution studies indicate that the gtp binding site has a relative affinity for guanine nucleotides in the order gtp = gtp gamma s greater than gdp = gmp-p ( nh ) p greater than gdp beta s with the highest difference ( gtp versus gdp beta s ) being about 10-fold . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
89,
108
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
239,
242
]
} |
isotopic dilution studies indicate that the gtp binding site has a relative affinity for guanine nucleotides in the order gtp = gtp gamma s greater than gdp = gmp-p ( nh ) p greater than gdp beta s with the highest difference ( gtp versus gdp beta s ) being about 10-fold . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
89,
108
]
} | {
"id": "C0018346",
"name": "gmp",
"pos": [
159,
162
]
} |
isotopic dilution studies indicate that the gtp binding site has a relative affinity for guanine nucleotides in the order gtp = gtp gamma s greater than gdp = gmp-p ( nh ) p greater than gdp beta s with the highest difference ( gtp versus gdp beta s ) being about 10-fold . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
89,
108
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
228,
231
]
} |
isotopic dilution studies indicate that the gtp binding site has a relative affinity for guanine nucleotides in the order gtp = gtp gamma s greater than gdp = gmp-p ( nh ) p greater than gdp beta s with the highest difference ( gtp versus gdp beta s ) being about 10-fold . | NA | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
128,
139
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
228,
231
]
} |
kinetoplast dna , the mitochondrial dna in trypanosomatids , is a network of thousands of interlocked circles . | NA | {
"id": "C0064360",
"name": "kinetoplast dna",
"pos": [
0,
15
]
} | {
"id": "C0012929",
"name": "mitochondrial dna",
"pos": [
22,
39
]
} |
the amino acids determined so far include arg , asp , cys , glu , met , trp , and asn-gly . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
4,
15
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
86,
89
]
} |
in an attempt to mimic possible host-tumor cell interactions that could account for the elevated gag levels in vivo , tumor cells were cocultured with fibroblasts , but no stimulation above the amount made by the tumor cells alone plus that by the fibroblasts alone was observed . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
124,
129
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
248,
259
]
} |
a high-performance liquid chromatographic method for the determination of prostaglandin e1 ( pge1 ) incorporated in white petrolatum , white ointment , hydrophilic petrolatum and plastibase was investigated . | NA | {
"id": "C0031262",
"name": "white petrolatum",
"pos": [
116,
132
]
} | {
"id": "C0282297",
"name": "hydrophilic petrolatum",
"pos": [
152,
174
]
} |
a method has been developed for the derivatization of both catecholamines ( dopamine , noradrenaline and adrenaline ) and their 3-o-methylated metabolites ( 3-methoxytyramine , normetanephrine and metanephrine ) in a single run . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
87,
100
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
105,
115
]
} |
a method has been developed for the derivatization of both catecholamines ( dopamine , noradrenaline and adrenaline ) and their 3-o-methylated metabolites ( 3-methoxytyramine , normetanephrine and metanephrine ) in a single run . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
87,
100
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
177,
192
]
} |
a method has been developed for the derivatization of both catecholamines ( dopamine , noradrenaline and adrenaline ) and their 3-o-methylated metabolites ( 3-methoxytyramine , normetanephrine and metanephrine ) in a single run . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
90,
100
]
} | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
197,
209
]
} |
the exchange of deuterium for hydrogen in the aromatic ring under derivatization conditions was found to be limited . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
16,
25
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
30,
38
]
} |
a procedure for the simultaneous analysis of brain pipecolic acid , proline , gamma-aminobutyric acid and glycine -- amino acids with potent inhibitory actions on the central nervous system -- was developed . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
106,
113
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
117,
128
]
} |
this methodology employs alumina chromatography and toluene solvent extraction to separate the catecholamine , iso , from the o-methylated derivative , meoiso . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
95,
108
]
} | {
"id": "C0022245",
"name": "iso",
"pos": [
155,
158
]
} |
human sera from pneumocystis carinii-infected patients and specific rabbit antisera have antibodies against the cyst form of the organism . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
75,
83
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
89,
99
]
} |
the in vitro activities of two cephamycins , cefotetan and cefoxitin , against 107 anaerobic bacteria were evaluated . | NA | {
"id": "C0007736",
"name": "cephamycins",
"pos": [
31,
42
]
} | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
45,
54
]
} |
the in vitro activities of two cephamycins , cefotetan and cefoxitin , against 107 anaerobic bacteria were evaluated . | NA | {
"id": "C0007736",
"name": "cephamycins",
"pos": [
31,
42
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
59,
68
]
} |
a hypothesis is presented in which the enzyme itself is the major determinant of phosphorylcreatine content by virtue of its ability to act as an intracellular binding protein for creatine derived from extracellular fluid , and also for cellular adp . | NA | {
"id": "C0031634",
"name": "phosphorylcreatine",
"pos": [
81,
99
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
180,
188
]
} |
to estimate the possible intra-blood-brain barrier ( bbb ) production of iga we have calculated an iga index : csf-iga/serum-iga : csf-albumin/serum-albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
135,
142
]
} | {
"id": "C0036773",
"name": "serum-albumin",
"pos": [
143,
156
]
} |
preincubation of aortic segments with 3h-factor ixa and von willebrand factor ( vwf ) /factor viii , followed by washing and addition of factor x , resulted in formation of factor xa . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
137,
145
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
173,
182
]
} |
mrna activity profiles were produced by two-dimensional gel electrophoretic separation of radioactively labeled products of an in vitro reticulocyte lysate system which had been programmed by hepatic rna . | NA | {
"id": "C0035696",
"name": "mrna",
"pos": [
0,
4
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
200,
203
]
} |
to elucidate the mechanism of this phenomenon , we studied three degrees of increasing severity of cda ( groups cda-1 , 2 , and 3 ) produced by one or two peritoneal dialyses against 0.15 m nahco3 and electrolyte infusions of different cl and hco3 content in sprague-dawley rats ; | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
190,
196
]
} | {
"id": "C0005367",
"name": "hco3",
"pos": [
243,
247
]
} |
extracellular fluid ( ecf ) volume was assessed by blood pressure , hematocrit , plasma protein concentration , and 125i-albumin space ; | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
88,
95
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
121,
128
]
} |
endo f alone removed 69 % of total hexose and d-galactose , and 71 % of sialic acid . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
35,
41
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
48,
57
]
} |
this methyl-b12 was decreased by exposure of fibroblasts in culture to nitrous oxide as was observed with control cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
45,
56
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
114,
119
]
} |
exposure of control fibroblasts during culture , but not of fibroblasts from this patient , to nitrous oxide significantly reduced the holoenzyme activity of methionine synthetase assayed in cell extracts . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
20,
31
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
191,
195
]
} |
skf 82526-j , or fenoldopam , a benzazepine derivative , is a selective dopamine-1 ( da-1 ) agonist devoid of activity at dopamine-2 , alpha- or beta-adrenergic receptors . | NA | {
"id": "C0060180",
"name": "fenoldopam",
"pos": [
17,
27
]
} | {
"id": "C0005034",
"name": "benzazepine",
"pos": [
32,
43
]
} |
to assess the role of elevated counterregulatory hormones in this response , we simultaneously infused cortisol ( 6 mg/m2 per h ) , glucagon ( 4 ng/kg per min ) , epinephrine ( 0.6 microgram/m2 per min ) , and norepinephrine ( 0.8 micrograms/m2 per min ) for 72 h into five obese subjects receiving only intravenous gluc... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
163,
174
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
210,
224
]
} |
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