text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
mononuclear cell conditioned factor ( mncf ) medium ( 5 % ) stimulated a 100-fold increase in basal human dermal fibroblast pge2 release over 48 h as compared with fibroblasts that were incubated with control medium ( conditioned medium prepared without cells ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
164,
175
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
254,
259
]
} |
fibroblasts pretreated with control medium released pge2 only modestly in response to 1 nm bradykinin for 1 h ( basal , 50 +/- 7 pg pge2/micrograms protein ; stimulated , 104 +/- 12 pg pge2/micrograms protein ) , whereas cells that had been pretreated with mncf showed a greatly facilitated bradykinin-induced release of... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
0,
11
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
221,
226
]
} |
a kinetic study of microsomal cyclooxygenase prepared from fibroblasts pretreated with mncf showed a threefold increase in the maximum velocity ( vmax ) but the same michaelis constant ( km ) as control-treated cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
59,
70
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
211,
216
]
} |
no such augmentation or induction of cytolytic activity was found with anti-t3 pretreatment when syngeneic cells or inappropriate allogeneic cells ( hla-a , b antigens different from the original priming stimulus ) were used as target cells and pretreatment of memory cells with anti-t4 or anti-t8 did not induce cytolyt... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
107,
112
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
130,
146
]
} |
pharmacokinetics and urinary excretion of clavulanic acid after oral administration of amoxicillin and potassium clavulanate . | NA | {
"id": "C0055860",
"name": "clavulanic acid",
"pos": [
42,
57
]
} | {
"id": "C0137997",
"name": "potassium clavulanate",
"pos": [
103,
124
]
} |
the pharmacokinetics and urinary excretion of clavulanic acid were studied in eight healthy adult volunteers after oral administration of 500 mg amoxicillin and 125 mg potassium clavulanate . | NA | {
"id": "C0055860",
"name": "clavulanic acid",
"pos": [
46,
61
]
} | {
"id": "C0137997",
"name": "potassium",
"pos": [
168,
177
]
} |
biochemically , there are elevated levels of protoporphyrin in erythrocytes and acetate-substituted porphyrins in the plasma , urine , and feces . | NA | {
"id": "C0033733",
"name": "protoporphyrin",
"pos": [
45,
59
]
} | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
100,
110
]
} |
oral rinses which included ( 1 ) an acidic calcium phosphate solution containing 0.7 m ca , 1.9 m po4 , and saturated with respect to cahpo4 . 2h2o , and with a ph of 2.0 , followed by ( 2 ) a 0.52 m fluoride solution , from naf or snf2 , were provided to rats once daily for seven days . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
200,
208
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
225,
228
]
} |
the effects of epinephrine , norepinephrine , and carbachol on oxygen consumption in rat sublingual gland slices . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
15,
26
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
29,
43
]
} |
epinephrine and carbachol , but not norepinephrine , significantly stimulated oxygen consumption in rat sublingual gland slices . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
36,
50
]
} |
excretion and peripheral metabolism of 1 , 2-3h-testosterone and androgens in rats following intoxication with organophosphorous insecticides . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
0,
9
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
25,
35
]
} |
the effects of methylbromphenvinfos ( mbfv ) and fenitrothion on androgen levels , excretion and peripheral metabolism were studied in male rats . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
83,
92
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
108,
118
]
} |
it is recommended that sheep with lantana poisoning be treated orally with 500 g of activated charcoal in 4 1 of electrolyte solution , and that cattle be given 2 kg of charcoal in 20 1 of electrolyte solution . | NA | {
"id": "C0001275",
"name": "activated charcoal",
"pos": [
84,
102
]
} | {
"id": "C0007955",
"name": "charcoal",
"pos": [
169,
177
]
} |
nuclear pk reactive with protamine as substrate was increased within 1-1/2 h after t3 administration , reaching a peak of 130 % of the control value at 5 h and returning to the normal level by 48 h . | NA | {
"id": "C0028589",
"name": "nuclear pk",
"pos": [
0,
10
]
} | {
"id": "C0033603",
"name": "protamine",
"pos": [
25,
34
]
} |
both proteins ( tg and albumin ) were poorly iodinated in hurthle carcinoma tissue , and the iodination of albumina seemed to be more severely impaired . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
5,
13
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
107,
114
]
} |
edema patients demonstrated greater orthostatic weight gain , greater upright epinephrine values , and greater supine and upright norepinephrine values than did the control group . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
78,
89
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
130,
144
]
} |
in edema patients there was a greater supine and posture related norepinephrine and epinephrine to dopamine ratio than in normal controls . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
65,
79
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
84,
95
]
} |
hla phenotyping of the reported patient demonstrated neither of the two genetic markers previously noted among chinese with thyrotoxic periodic paralysis , indicating that these haplotypes do not serve as markers for the disorder in blacks . | NA | {
"id": "C0017393",
"name": "genetic markers",
"pos": [
72,
87
]
} | {
"id": "C0005516",
"name": "markers",
"pos": [
205,
212
]
} |
absorption of antisera with egg-grown a/porcine/shope/1/33 influenza virus eliminated cross-reactive antibodies so that specific detection of anti-equine influenza a1 or a2 antibodies was possible . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
14,
22
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
173,
183
]
} |
the glycosyl 1-phosphate units are novel types of antigenic determinants and antigens with such determinants should be useful for investigating the interactions of antigens with homologous antibodies . | NA | {
"id": "C0003316",
"name": "antigens",
"pos": [
77,
85
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
164,
172
]
} |
a monoclonal antibody defining the lewis blood group determinant was used to immobilize antigen in sera of patients with adenocarcinoma of the gastrointestinal tract , and a second radiolabeled antibody , which defines a gastrointestinal cancer-associated antigen ( gica ) , was used to detect the immobilized antigen . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
2,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
194,
202
]
} |
monoclonal antibodies of igg and igm classes were used in the first step , and colloidal gold-labelled anti-mouse igg antibody and peroxidase-labelled anti-mouse igm antibody ( mu chain-specific ) in the second step . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
0,
10
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
166,
174
]
} |
cases of squamous cell carcinoma in situ ( bowen 's disease ) revealed increased staining for involucrin with staining of dyskeratotic cells at all levels in the epithelium . | NA | {
"id": "C0007137",
"name": "squamous cell carcinoma",
"pos": [
9,
32
]
} | {
"id": "C0006079",
"name": "bowen 's disease",
"pos": [
43,
59
]
} |
using immunoblot techniques 3 selected sera were shown to bind to high-molecular-weight ( hmw ) kif proteins which had been extracted from 2 different epidermal cell preparations , that is , human callus or epidermis from which the sc had been removed by tape-stripping . | NA | {
"id": "C0010803",
"name": "kif",
"pos": [
96,
99
]
} | {
"id": "C0021769",
"name": "kif proteins",
"pos": [
96,
108
]
} |
immunoblot experiments , which are more sensitive than indirect immunofluorescence , demonstrated the absorption of anti-kif protein antibodies of the 3 test sera on callus kif and 2 of the sera on kif obtained from epidermis without sc . | NA | {
"id": "C0010803",
"name": "kif",
"pos": [
121,
124
]
} | {
"id": "C0021769",
"name": "kif protein",
"pos": [
121,
132
]
} |
this was shown by the lack of staining of the respective hmw kif proteins with the postabsorption sera . | NA | {
"id": "C0010803",
"name": "kif",
"pos": [
61,
64
]
} | {
"id": "C0021769",
"name": "kif proteins",
"pos": [
61,
73
]
} |
rodent epidermal langerhans cells demonstrate greater histochemical specificity for adp than for atp and amp . | NA | {
"id": "C0001459",
"name": "adp",
"pos": [
84,
87
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
105,
108
]
} |
rodent epidermal langerhans cells demonstrate greater histochemical specificity for adp than for atp and amp . | NA | {
"id": "C0001480",
"name": "atp",
"pos": [
97,
100
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
105,
108
]
} |
langerhans cells ( lcs ) in mammalian epidermis possess the ectoenzyme ca++/mg++-dependent adenosine triphosphatase ( atpase ) , which has served as a useful histochemical marker for these dendritic cells in a variety of tissue preparations . | NA | {
"id": "C0001477",
"name": "ca",
"pos": [
71,
73
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
118,
124
]
} |
we conclude from these studies that adp demonstrates greater specificity for lc surface polyphosphatase activity than atp and that the inadvertent inclusion of amp during identification procedures for epidermal cell suspensions will falsely identify cells other than lcs . | NA | {
"id": "C0001459",
"name": "adp",
"pos": [
36,
39
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
160,
163
]
} |
we conclude from these studies that adp demonstrates greater specificity for lc surface polyphosphatase activity than atp and that the inadvertent inclusion of amp during identification procedures for epidermal cell suspensions will falsely identify cells other than lcs . | NA | {
"id": "C0001480",
"name": "atp",
"pos": [
118,
121
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
160,
163
]
} |
these characteristics distinguished the enzyme from the intestinal isoenzyme that is found in normal swine skin but were similar to those exhibited by the porcine placental isoenzyme of alkaline phosphatase . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
40,
46
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
173,
182
]
} |
it is suggested that collagenolytic activity for the ovulatory process started to intensiby 6hrs and ended 3hrs prior to ovulation and pgs are necessary for the enzymatic activation of dnp peptidase and bana hydrolase . | NA | {
"id": "C0030940",
"name": "peptidase",
"pos": [
189,
198
]
} | {
"id": "C0020289",
"name": "hydrolase",
"pos": [
208,
217
]
} |
other malignant tumours that can occur in children include melanoma and other mesenchymal tumours , including undifferentiated sarcoma , fibrosarcoma , osteogenic sarcomas and ewing sarcoma . | NA | {
"id": "C0029463",
"name": "osteogenic sarcomas",
"pos": [
152,
171
]
} | {
"id": "C0553580",
"name": "ewing sarcoma",
"pos": [
176,
189
]
} |
osseous disorders of the temporal bone , such as eosinophilic granuloma and hand-schuller-christian disease , should be included as a differential diagnosis ( lewis , 1979 ) . | NA | {
"id": "C0005940",
"name": "disorders of",
"pos": [
8,
20
]
} | {
"id": "C0014461",
"name": "eosinophilic",
"pos": [
49,
61
]
} |
quantitative alterations of lipid and lipoprotein composition appear in the bb wistar rat when compared to the wistar rat , but some of the changes are more pronounced in the spontaneously diabetic bb wistar rat . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
28,
33
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
38,
49
]
} |
isolate f-14 formed ursocholic acid ( uc ) and 7-ketodeoxycholic acid ( 7-kdc ) from cholic acid ( ca ) , and ursodeoxycholic acid ( udc ) and 7-ketolithocholic acid ( 7-klc ) from chenodeoxycholic acid ( cdc ) in whole cell cultures , but did not transform deoxycholic acid ( dc ) . | NA | {
"id": "C0042105",
"name": "ursodeoxycholic acid",
"pos": [
110,
130
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
258,
274
]
} |
isolate f-14 formed ursocholic acid ( uc ) and 7-ketodeoxycholic acid ( 7-kdc ) from cholic acid ( ca ) , and ursodeoxycholic acid ( udc ) and 7-ketolithocholic acid ( 7-klc ) from chenodeoxycholic acid ( cdc ) in whole cell cultures , but did not transform deoxycholic acid ( dc ) . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
181,
202
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
258,
274
]
} |
we previously showed that immunization of guinea pigs with reductively glucosylated guinea pig low density lipoprotein ( ldl ) or albumin resulted in the formation of antibodies specific for the glucosylated protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
130,
137
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
208,
215
]
} |
the present studies were done to determine if modifications of homologous ldl or albumin , other than addition of carbohydrate , would also render these proteins immunogenic . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
81,
88
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
153,
161
]
} |
however , antibodies generated against guinea pig albumin ( or fibrinogen ) modified in the same ways reacted primarily with the modified protein used as immunogen , and not with the free lysine derivative , or with other similarly modified proteins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
50,
57
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
241,
249
]
} |
we have isolated an unusual acidic glycolipid which was detected in the lower phase of the folch partition of the total lipid extract of human liver during a routine isolation of glycosphingolipids . | NA | {
"id": "C0017950",
"name": "glycolipid",
"pos": [
35,
45
]
} | {
"id": "C0017978",
"name": "glycosphingolipids",
"pos": [
179,
197
]
} |
with the solvent systems commonly used for thin-layer chromatography of glycosphingolipids , this glycolipid has a mobility similar to gbose3cer , one of the major glycosphingolipids in human liver . | NA | {
"id": "C0017950",
"name": "glycolipid",
"pos": [
98,
108
]
} | {
"id": "C0017978",
"name": "glycosphingolipids",
"pos": [
164,
182
]
} |
the first mobile phase , hexane-2-propanol-acetic acid 100:0.5:01 , resulted in incomplete separation of cholesteryl ester and triglyceride but excellent separations of fatty acids and cholesterol . | NA | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
105,
122
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
185,
196
]
} |
bendaline , like tiadenol , clofibrate and clofibric acid generally inhibits : a ) some hyperlipemias and lipoidoses induced by either an increased exogenous supply of lipids or the stimulation of cholesterol synthesis or mobilization of lipids ; | NA | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
28,
38
]
} | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
43,
57
]
} |
during these experiments , we observed that if a tumor was `` '' cured '' '' by radiation therapy , it required inoculation of a larger number of cells to establish a second tumor . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
49,
54
]
} | {
"id": "C0085183",
"name": "a second tum",
"pos": [
165,
177
]
} |
on the other hand , if a second tumor was already established , less tumor cells were needed to establish a third tumor . | NA | {
"id": "C0085183",
"name": "second tumor",
"pos": [
25,
37
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
114,
119
]
} |
we investigated the capacity of bacterial endotoxin ( lipopolysaccharide , lps ) to modify the oxidative metabolic response to membrane stimulation of human neutrophils . | NA | {
"id": "C0014264",
"name": "bacterial endotoxin",
"pos": [
32,
51
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
75,
78
]
} |
the suppression observed here , which is anti-self from the point of view of the added ctl clone , appears to be triggered by precursor cells in the mlr responder population recognizing mhc determinants on cells from the added ctl clone . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
126,
141
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
206,
211
]
} |
to assess the role of ia epitopes in conferring specificity for the immune response to nominal antigen , we compared the insulin response of mice with a defined mutation in the i-ab beta gene , the b6.c-h-2bm12 ( bm12 ) , with that of wild-type h-2b c57bl/6 ( b6 ) mice . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
25,
33
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
95,
102
]
} |
the potentiating effect of a purine was dependent upon the activity of the appropriate phosphoribosyl transferase : a gpt mutant strain was not potentiated by guanine but remained fully sensitive to the addition of adenine . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
29,
35
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
215,
222
]
} |
a 960 bp restriction fragment ( hinfi e ) of a class ii defective hsv-1 ang dna has been sequenced using the viral dna rather than molecularly cloned dna . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
109,
118
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
150,
153
]
} |
two monoclonal antibodies reacted with the spike protein and two reacted with the membrane protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
49,
56
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
82,
98
]
} |
the reactions of the monoclonal antibodies showed that one ( s1 ) of the two glycopolypeptides associated with the spike protein has a strain-specific region involved in neutralization and haemagglutination , and the membrane protein has antigenic determinants which are present on the three strains of ibv tested ( m41 ... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
121,
128
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
217,
233
]
} |
a method for extraction of cellular cmv dna is described which uses cmv dna released into the hirt supernatant after precipitation of cellular dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
143,
146
]
} |
although transferrin reacts with the vanadate anion , studies on the transferrin model compound ethylenebis ( o-hydroxyphenylglycine ) indicate that at ph 9.5 , the vanadium is binding at the metal-binding site as a dioxovanadium ( v ) cation coordinated to two phenolic residues at each binding site . | NA | {
"id": "C0042305",
"name": "vanadate",
"pos": [
37,
45
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
46,
51
]
} |
therapeutic response of absence seizures in patients of an epilepsy clinic for adolescents and adults . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
32,
40
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
59,
67
]
} |
responses of seizures to therapy is one of the most important prognostic factors in epilepsy . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
13,
21
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
84,
92
]
} |
because complications of the diabetic pregnancy include an increased risk of hypertension in the mother and sudden , unexplained fetal loss , two complications associated with abnormal clotting , the increase in fibrin catabolism in patients in tight metabolic control would suggest that events other than glucose regula... | NA | {
"id": "C0032962",
"name": "complications of",
"pos": [
8,
24
]
} | {
"id": "C0032969",
"name": "pregnancy",
"pos": [
368,
377
]
} |
these results suggest that some of cephalosporins such as ceftezole , cefotiam , cephacetrile and cefazolin provide epileptogenic activity at higher doses . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
35,
49
]
} | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
81,
93
]
} |
tritiated budesonide and beclomethasone 17 alpha,21-dipropionate ( bdp ) were incubated with the 9000g supernatant of human liver homogenate . | NA | {
"id": "C0004905",
"name": "beclomethasone",
"pos": [
25,
39
]
} | {
"id": "C0004906",
"name": "bdp",
"pos": [
67,
70
]
} |
when applied to the ganglia in the concentrations of 1-100 microm for 3-5 min , adrenaline , isoprenaline and noradrenaline produced an initial , short-lasting depression which was followed by a marked augmentation of the non-cholinergic e.p.s.p . lasting from minutes to over hours . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
80,
90
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
110,
123
]
} |
in oocytes exposed to the mitochondrial uncoupler dnp ( 2,4-dinitrophenol ) , the shape of the arsenazo iii absorbance spectrum was found to change . | NA | {
"id": "C0045511",
"name": "dnp",
"pos": [
50,
53
]
} | {
"id": "C0012466",
"name": "dinitrophenol",
"pos": [
60,
73
]
} |
although the absolute amounts of adrenaline and noradrenaline released in response to splanchnic nerve stimulation were significantly less in 24-48 h old calves , the ratio ( 3:2 ) was the same as that found in 2-5 week old animals and that in which the two amines are stored in the gland . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
33,
43
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
48,
61
]
} |
however , they also show that the ratio in which adrenaline and noradrenaline are released from the adrenal medullae provide no index of this process , as had previously been suggested . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
49,
59
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
64,
77
]
} |
15 min after the start of immersion , plasma epinephrine and norepinephrine were largely increased , plasma cortisol was moderately enhanced , while no change was observed in plasma insulin , t4 , t3 and tsh concentrations . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
45,
56
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
61,
75
]
} |
t4 concentration was decreased , cortisol did not change , noradrenaline tended to be higher , and epinephrine was increased . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
59,
72
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
99,
110
]
} |
negative correlations were found between colonic temperature and plasma epinephrine and between colonic temperature and plasma norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
72,
83
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
127,
141
]
} |
using 28 blood group markers , a prior association study between the trait defining susceptibility to affective disorder and the genetic marker was positive for haptoglobin gc , and properdinfactor b , confirming earlier findings . | NA | {
"id": "C0005516",
"name": "markers",
"pos": [
21,
28
]
} | {
"id": "C0017393",
"name": "genetic marker",
"pos": [
129,
143
]
} |
the nvas could be shown best in systems in which hyperimmune rabbit sera ( adsorbed with procyclic forms to eliminate antibodies against antigens common to bloodstream form and procyclic stages ) were reacted with trypanosomes characterized by heterologous variant-specific antigens ( vsas ) . | NA | {
"id": "C0003320",
"name": "nvas",
"pos": [
4,
8
]
} | {
"id": "C0003333",
"name": "heterologous",
"pos": [
244,
256
]
} |
metabolism of [ 3h ] pregnenolone to 17 alpha-hydroxypregnenolone and [ 3h ] progesterone to 17 alpha-hydroxyprogesterone occurred at low rates ( 1-7 % ) , suggesting the presence of c21 steroid 17 alpha-hydroxylase in skunk cl . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
21,
33
]
} | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
37,
65
]
} |
this review discusses those enas which are ribonucleoproteins ( rnps ) consisting of small rna molecules ( 80-400 nucleotides ) attached to non-histone proteins : these are called small nuclear ( sn ) or small cytoplasmic ( sc ) ribonucleoproteins according to their location in the cell and at least some are known to p... | NA | {
"id": "C0035544",
"name": "ribonucleoproteins",
"pos": [
43,
61
]
} | {
"id": "C0752106",
"name": "small",
"pos": [
204,
209
]
} |
the anion preference of or k+ efflux in nem-treated cells was br- greater than cl- greater than hco3- = f- much greater than i- = no3- = cns- , and hence consistent with a reported br- greater than cl- greater than no3- sequence of the volume-dependent k+cl- transport . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
4,
9
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
230,
231
]
} |
the anion preference of or k+ efflux in nem-treated cells was br- greater than cl- greater than hco3- = f- much greater than i- = no3- = cns- , and hence consistent with a reported br- greater than cl- greater than no3- sequence of the volume-dependent k+cl- transport . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
4,
9
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
166,
167
]
} |
in vitro translation experiments show that the salivary gland messenger rna population derived from a stock that fails to synthesize the group v rna does not direct the synthesis of a polypeptide similar in molecular weight to protein p4 . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
62,
75
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
145,
148
]
} |
such sequences constitute important functional domains of the rna and may contribute to the putative role of this rna region in the peptidyl transferase centre . | NA | {
"id": "C0887909",
"name": "functional",
"pos": [
36,
46
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
114,
117
]
} |
the properties have been determined of a recently identified form of bovine pancreatic trypsin inhibitor , with only two of the three disulphide bonds of the native protein , but possessing a native-like conformation . | NA | {
"id": "C0003641",
"name": "bovine",
"pos": [
69,
75
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
165,
172
]
} |
yeast enolase ( 2-phospho-d-glycerate hydrolyase , ec 4.2.1.11 ) has been crystallized by vapor diffusion and equilibrium dialysis of solutions of ammonium sulfate . | NA | {
"id": "C0031691",
"name": "enolase",
"pos": [
6,
13
]
} | {
"id": "C0020239",
"name": "hydrolyase",
"pos": [
38,
48
]
} |
titin comprises approximately 9 % of the myofibrillar mass , which means that it is the third most abundant protein in muscle . | NA | {
"id": "C0056248",
"name": "titin",
"pos": [
0,
5
]
} | {
"id": "C0026832",
"name": "protein",
"pos": [
108,
115
]
} |
high levels of radioactivity in free fatty acid in the hearts perfused with erucic acid suggest that a low rate of activation of the fatty acid to acyl-coa limits both oxidation and the formation of triacylglycerol . | NA | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
32,
47
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
133,
143
]
} |
these messenger rna classes are coordinately controlled , with each rna appearing in the third larval instar and disappearing at the time of puparium formation . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
6,
19
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
68,
71
]
} |
quantitation of base substitutions in eukaryotic 5s rrna : selection for the maintenance of rna secondary structure . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
52,
56
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
92,
95
]
} |
the 5.8s rna gene of eukaryotes is separated from the 26-28s rrna gene by the internal transcribed spacer 2 ( its 2 ) . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
9,
12
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
61,
65
]
} |
since the transcripts of rrna its 2 and mrna introns share some similarity , analogies have been made between the mechanisms of their removal during rna maturation . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
25,
29
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
149,
152
]
} |
furthermore , [ 3h ] -arachidonic acid was also rapidly released from prelabeled phospholipids concomitant with a decrease in radioactivity in various phospholipid fractions . | NA | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
81,
94
]
} | {
"id": "C0771648",
"name": "phospholipid fractions",
"pos": [
151,
173
]
} |
the concentrations of anaphylatoxins ( c4a , c3a , and c5a ) and other complement components ( c1inh , c4 , c3 , and c5 ) were determined in plasma using radioimmunoassay and rocket immunoelectrophoresis techniques . | NA | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
22,
36
]
} | {
"id": "C0009510",
"name": "c3a",
"pos": [
45,
48
]
} |
segmental xgp should be distinguished from focal xanthogranulomatous inflammation of the kidney , which is a distinct pathologic entity ( cortical location , no pelvic communication , absent pyelitis ) . | NA | {
"id": "C0027697",
"name": "inflammation of",
"pos": [
69,
84
]
} | {
"id": "C0034183",
"name": "pyelitis",
"pos": [
191,
199
]
} |
in an attempt to prove that myocarditis may be a cause of idiopathic cardiomyopathy , 10 cases with acute myocarditis were involved in a long-term follow-up study . | NA | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
28,
39
]
} | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
69,
83
]
} |
this was comparable to the percentage inhibited by some aminoglycosides ( gentamicin , tobramycin , amikacin and sisomicin ) ranging from 60 to 80 % . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
74,
84
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
113,
122
]
} |
comparison was made with the mic and mbc values of benzylpenicillin ( pcg ) and ampicillin ( abpc ) . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
51,
67
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
80,
90
]
} |
it is thus apparent that pcg showed the lowest values for both the mic and mbc , followed by ctx , ctrx and then des-ctx . | NA | {
"id": "C0007561",
"name": "ctrx",
"pos": [
99,
103
]
} | {
"id": "C0007554",
"name": "ctx",
"pos": [
117,
120
]
} |
similarly , the mbc 90 values of des-ctx were 0.78 and 0.39 micrograms/ml , while the other 3 antibiotics showed the same values with both the 10 ( 8 ) and 10 ( 6 ) cells/ml inocula : 0.10 micrograms/ml for ctx , 0.20 micrograms/ml for ctrx and 0.39 micrograms/ml for pcg . | NA | {
"id": "C0007554",
"name": "ctx",
"pos": [
37,
40
]
} | {
"id": "C0007561",
"name": "ctrx",
"pos": [
236,
240
]
} |
accordingly , ctx showed the lowest values , followed by ctrx and then pcg being about the same as des-ctx . | NA | {
"id": "C0007561",
"name": "ctrx",
"pos": [
57,
61
]
} | {
"id": "C0007554",
"name": "ctx",
"pos": [
103,
106
]
} |
accordingly , in terms of the mic 90 , ctx and ctrx showed the same values , but in terms of the mbc 90 ctx was superior . | NA | {
"id": "C0007561",
"name": "ctrx",
"pos": [
47,
51
]
} | {
"id": "C0007554",
"name": "ctx",
"pos": [
104,
107
]
} |
dopamine-induced shortening of sact was blocked by a beta-adrenoceptor blocker , propranolol , and an uptake blocker , imipramine , but not by a dopaminergic inhibitor , sulpiride . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
0,
8
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
145,
157
]
} |
this case seems to be most characterized by its very unusual urinary 17-ketosteroid ( ks ) fractionation , since markedly increased etiocholanolone was not accompanied by increments of either dhea or androsterone . | NA | {
"id": "C0000167",
"name": "17-ketosteroid",
"pos": [
69,
83
]
} | {
"id": "C0015124",
"name": "etiocholanolone",
"pos": [
132,
147
]
} |
this case seems to be most characterized by its very unusual urinary 17-ketosteroid ( ks ) fractionation , since markedly increased etiocholanolone was not accompanied by increments of either dhea or androsterone . | NA | {
"id": "C0000167",
"name": "17-ketosteroid",
"pos": [
69,
83
]
} | {
"id": "C0002865",
"name": "androsterone",
"pos": [
200,
212
]
} |
therefore , it seems plausible that the unique 17-ks fractionation of this patient would have ensued as a result of remarkably decreased c17-20 lyase activity sufficient to nullify the increased 17-oh-pregnenolone and that markedly increased etiocholanolone might have been converted from 11-deoxycortisol . | NA | {
"id": "C0000167",
"name": "17-ks",
"pos": [
47,
52
]
} | {
"id": "C0015124",
"name": "etiocholanolone",
"pos": [
242,
257
]
} |
by high performance liquid chromatography with a zorbax ods reversed-phase column , the retention times of materials a , c and d were found to be equal to those of materials a ' , c ' and d ' , and they were not equal to those of kallidin , methionyl-lysyl-bradykinin ( mlbk ) and bradykinin ( bk ) . | NA | {
"id": "C0022474",
"name": "lysyl-bradykinin",
"pos": [
251,
267
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
281,
291
]
} |
the lipophilic characters of 8 kinds of cardenolides , evaluated from rm or log k ' values by means of thin layer chromatography ( rf ) or high performance liquid chromatography ( retention time ) , increased in the order of ouabain , digoxin , digitoxigenin , digitoxigenin-monodigitoxoside , digitoxigenin-bis-digitoxo... | NA | {
"id": "C0012257",
"name": "digitoxigenin",
"pos": [
245,
258
]
} | {
"id": "C0012258",
"name": "digitoxin",
"pos": [
374,
383
]
} |
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