text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in anticipation of problems associated with portal hypertension in pregnancy , prophylactic splenorenal shunt was performed during the second trimester . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
67,
76
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
135,
151
]
} |
nontransformed cells [ bovine aortic endothelial cells , adult human gingival fibroblasts ( strains 423 and 1101 ) , fetal rat skin ( strain 921-k ) and muscle fibroblasts ] required longer exposure to induce inhibition than did neoplastic cells [ rat 3-methylcholanthrene-induced fibrosarcoma cell lines ( mca-6 and mca... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
78,
89
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
537,
542
]
} |
nonspecific and unregulated delivery of retinoids to biologic membranes apparently leads to vitamin a ( retinoid ) toxicity . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
92,
101
]
} | {
"id": "C0035339",
"name": "retinoid",
"pos": [
104,
112
]
} |
these procedures fractionate complex mixtures of retinoids and carotenoids into only three fractions , e.g. , retinoids , carotenes , and xanthophylls . | NA | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
63,
74
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
110,
119
]
} |
these procedures fractionate complex mixtures of retinoids and carotenoids into only three fractions , e.g. , retinoids , carotenes , and xanthophylls . | NA | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
63,
74
]
} | {
"id": "C0949636",
"name": "xanthophylls",
"pos": [
138,
150
]
} |
information about the intake of specific species of retinoids or carotenoids is not available and could not be calculated from existing food tables . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
52,
61
]
} | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
65,
76
]
} |
limited applications of new separation techniques and chemical instrumentation have demonstrated the potential for generating detailed analytic information in regard to the retinoid and carotenoid contents of foods . | NA | {
"id": "C0035339",
"name": "retinoid",
"pos": [
173,
181
]
} | {
"id": "C0007271",
"name": "carotenoid",
"pos": [
186,
196
]
} |
nhl with a predominance of t-suppressor ( ts ) lymphocytes include the immunoblastic lymphadenopathy like t-cell lymphoma ( okt-3 , okt-8 , okt-11 ) and some lymphoepitheloid ( lennert ) lymphomas . | NA | {
"id": "C0024305",
"name": "nhl",
"pos": [
0,
3
]
} | {
"id": "C0079772",
"name": "t-cell lymphoma",
"pos": [
106,
121
]
} |
we measured basal and dexamethasone-suppressed plasma acth in 246 patients with bronchogenic carcinoma ( 105 with small-cell carcinoma ) ; | NA | {
"id": "C0007121",
"name": "bronchogenic carcinoma",
"pos": [
80,
102
]
} | {
"id": "C0149925",
"name": "small-cell carcinoma",
"pos": [
114,
134
]
} |
the peripheral metabolism depends ultimately upon a prevalence of thyroid gland stimulation ( thyrotoxicosis ) or glandular destruction ( hypothyroidism ) and this is true for overt thyroid disease under antithyroid drug therapy or any other therapy . | NA | {
"id": "C0020676",
"name": "hypothyroidism",
"pos": [
138,
152
]
} | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
182,
197
]
} |
it can therefore be concluded that the preflight diet should be supplemented with methionine and aspartic acid , and the flight and postflight diets with 7 essential amino acids plus cystine , arginine , proline and aspartic acid . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
82,
92
]
} | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
156,
177
]
} |
the metabolism of estrone sulfate and dehydroisoandrosterone sulfate to the free , unconjugated steroids , estrone and dehydroisoandrosterone , was demonstrated in more than thirty different tissues from male and female balb/c mice . | NA | {
"id": "C0057277",
"name": "dehydroisoandrosterone sulfate",
"pos": [
38,
68
]
} | {
"id": "C0011185",
"name": "dehydroisoandrosterone",
"pos": [
119,
141
]
} |
the results can be summarized as follows : the ac of the leydig cell tumors was stimulated by isoproterenol , epinephrine , norepinephrine , dopamine , glucagon , pge1 , pgf2 alpha and lh/hcg . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
110,
121
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
124,
138
]
} |
after 72 h acth-cells cultured in the presence of acth converted 18.5 % of the pregnenolone substrate to 17-hydroxycorticosteroids ( cortisol plus 11-deoxycortisol ) while acth-cells cultured in the absence of acth converted a maximum of 1.6 % . | NA | {
"id": "C0000163",
"name": "17-hydroxycorticosteroids",
"pos": [
105,
130
]
} | {
"id": "C0010139",
"name": "11-deoxycortisol",
"pos": [
147,
163
]
} |
two procedures of the timm sulphide-silver method for the ultrastructural location of heavy metals and a sulphide-osmium procedure proposed here were applied to studying the timm-reacting axonal boutons of the lizard cerebral cortex . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
86,
98
]
} | {
"id": "C0029383",
"name": "osmium",
"pos": [
114,
120
]
} |
plasma catecholamines are off-line extracted using aluminum oxide and then on-line enriched on cation exchange enrichment hplc columns and back-eluted using a potassium enriched mobile phase for further separation by ion-pair , reverse phase hplc . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
95,
101
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
217,
220
]
} |
the salient features of this method are ( 1 ) the on-line combination of distinct hplc retention mechanisms for enrichment and separation of the catecholamines to yield optimal assay specificity , ( 2 ) a lower working limit of detection of 25 pg norepinephrine and epinephrine per milliliter plasma based upon an assaye... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
247,
261
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
266,
277
]
} |
the advantages of this method relative to other hplc-ec assays for plasma norepinephrine and epinephrine are discussed as are the general considerations to be addressed when defining performance characteristics of an assay . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
74,
88
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
93,
104
]
} |
in addition , this method will detect at least one example from every described class of calcium-binding protein , including lectins and gamma-carboxyglutamic acid containing calcium-binding proteins . | NA | {
"id": "C0006732",
"name": "calcium-binding",
"pos": [
89,
104
]
} | {
"id": "C0029419",
"name": "gamma-carboxyglutamic acid containing",
"pos": [
137,
174
]
} |
the research findings tend to oppose the notions that young children should not receive information , that all children benefit equally from the same type and timing of preparation , that a child who has had a previous experience requires less preparation , and that a one-time pre-admission program provides adequate pr... | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
54,
68
]
} | {
"id": "C0008059",
"name": "child",
"pos": [
190,
195
]
} |
when ffa was injected as a small bolus the fractional rates of ffa disappearance and of ffa incorporation into triacylglycerol in the different fat pads , observed during a 60-min period , were the same ( about 5 min or less ) regardless of the region of the fat pad studied ( distal or proximal epididymal fat pad ) , t... | NA | {
"id": "C0015684",
"name": "ffa",
"pos": [
5,
8
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
88,
91
]
} |
the leukotrienes are acyclic eicosanoids that arise through the 5-lipoxygenase pathway from eicosatrienoic , eicosatetraenoic , and eicosapentaenoic acid . | NA | {
"id": "C0013725",
"name": "eicosanoids",
"pos": [
29,
40
]
} | {
"id": "C0000545",
"name": "eicosapentaenoic acid",
"pos": [
132,
153
]
} |
reaction of lta4 , another lipoxygenase metabolite of arachidonic acid , with glutathione yields peptidolipid leukotrienes , ltc4 , ltd4 , and lte4 ; | NA | {
"id": "C0125631",
"name": "lta4",
"pos": [
12,
16
]
} | {
"id": "C0023545",
"name": "leukotrienes",
"pos": [
110,
122
]
} |
genetic animal models of epilepsy comprise genetically predisposed animal species in which seizures either occur spontaneously or in response to sensory stimulation . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
25,
33
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
91,
99
]
} |
models with idiopathic spontaneous recurrent seizures are epileptic dogs , tottering mice , and rats with spike-wave absence ( petit mal ) seizures . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
58,
67
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
139,
147
]
} |
the occurrence of seronegative but virus-positive persons without clinical symptoms suggests that assays other than those detecting antibody to virus , perhaps based on detection of viral antigens or immune complexes , may be required to identify all infected individuals . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
132,
140
]
} | {
"id": "C0003313",
"name": "immune",
"pos": [
200,
206
]
} |
other effective anions were cl- , no3- and formate while f- , hco3-cio4- , propionate , so42- and po43- were ineffective . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
16,
22
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
113,
114
]
} |
somatostatin-20 : a novel nh2-terminally extended form of somatostatin isolated from porcine duodenum together with somatostatin-28 and somatostatin-25 . | NA | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
0,
12
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
116,
131
]
} |
the substances were determined to be nh2-terminally extended forms of somatostatin , i.e . somatostatin-28 , somatostatin-25 and somatostatin-20 . | NA | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
70,
82
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
91,
106
]
} |
studies into the distribution of sulfate residues in hs after selective deamination of the glucosamine units within the glycosaminoglycan ( gag ) -chain , demonstrated that o-sulfate groups are preferentially located in relatively small deamination products : tetrasaccharides and disaccharides . | NA | {
"id": "C0019143",
"name": "hs",
"pos": [
53,
55
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
120,
137
]
} |
the presence of a large number of nerves containing npy suggest that this active neuropeptide may play a role in control of genital function . | NA | {
"id": "C0027893",
"name": "npy",
"pos": [
52,
55
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
81,
93
]
} |
of the exogenously added tachykinins , both eledoisin ( 8 times ) and physalaemin ( 3 times ) were more potent bronchoconstrictors than sp . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
25,
36
]
} | {
"id": "C0038585",
"name": "sp",
"pos": [
136,
138
]
} |
pretreatment with the sp-analogues shifted concentration-response curves to the tachykinins to the right , eledoisin being most readily antagonized . | NA | {
"id": "C0038585",
"name": "sp",
"pos": [
22,
24
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
80,
91
]
} |
it is concluded that if a tachykinin contributes to non-cholinergic bronchoconstriction , an eledoisin-like peptide is a more likely candidate than sp itself . | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
26,
36
]
} | {
"id": "C0038585",
"name": "sp",
"pos": [
148,
150
]
} |
plasma concentrations of vasopressin ( antidiuretic hormone ) , a powerful pressor agent and primary regulator of body fluid homeostasis , are elevated in a dose-related fashion to increases in exercise intensity . | NA | {
"id": "C0003779",
"name": "vasopressin",
"pos": [
25,
36
]
} | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
39,
59
]
} |
significant ( p less than 0.05 ) decreases were observed in ve ( ventilation ) ( 13 % ) , epinephrine ( 37 % ) , norepinephrine ( 26 % ) , and blood lactate ( 28 % ) , with no change in oxygen uptake ( vo2 ) , carbon dioxide production ( vco2 ) , or respiratory exchange ratio ( r ) during hyperoxia at the same absolute... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
90,
101
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
113,
127
]
} |
however , at the same relative power outputs ( nvo2n vs hvo2h ) no significant changes in ve , epinephrine , norepinephrine , or blood lactate were observed when hyperoxia and normoxia were compared . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
95,
106
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
109,
123
]
} |
tissue culture assay was used for the detection of cytotoxin ( toxin b ) and ileal loop test for enterotoxin ( toxin a ) . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
97,
108
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
111,
116
]
} |
the filamentous ascomycete aspergillus awamori secretes large amounts of glucoamylase upon growth in medium containing starch , glucose , or a variety of hexose sugars and sugar polymers . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
128,
135
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
154,
160
]
} |
rnas homologous to these loci have been identified by rna transfer hybridization , and the specific rnas which are associated with the rna+ phenotype have been mapped . | NA | {
"id": "C0035711",
"name": "rna transfer",
"pos": [
54,
66
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
135,
138
]
} |
we isolated from human lymphocytes a cdna clone whose gene is inducible by the phorbol ester 12-o-tetradecanoyl-phorbol-13-acetate as well as by the t-cell mitogen phytohemagglutinin . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
79,
92
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
112,
119
]
} |
in vivo gangliosides are found only in cell membranes or in lipoproteins , where they represent a small mole percent of total lipids , and there is little information about the transfer of gangliosides from lipoproteins to cells in vivo . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
126,
132
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
207,
219
]
} |
among the monosaccharides and glycosides tested for inhibition of precipitation , methyl alpha-d-mannose was most active and about 3.3 times as active as d-mannopyranose ( dman ) and only 1/200 as active as acid hapten or the carbohydrate moiety of clps prepared from s1119.3 ( expressed as a monosaccharide of mol . wt ... | NA | {
"id": "C0017977",
"name": "glycosides",
"pos": [
30,
40
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
344,
356
]
} |
among the monosaccharides and glycosides tested for inhibition of precipitation , methyl alpha-d-mannose was most active and about 3.3 times as active as d-mannopyranose ( dman ) and only 1/200 as active as acid hapten or the carbohydrate moiety of clps prepared from s1119.3 ( expressed as a monosaccharide of mol . wt ... | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
226,
238
]
} | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
293,
307
]
} |
the precipitability of the antibodies in this serum was greatly reduced after absorption with clps and the precipitin reaction was completely inhibited by the carbohydrate moiety of lps ( o-antigen ) s1119.3 demonstrating that the common antigenic determinants ( hapten ) of b. abortus lps reacting with these precipitat... | NA | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
188,
197
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
387,
390
]
} |
the precipitability of the antibodies in this serum was greatly reduced after absorption with clps and the precipitin reaction was completely inhibited by the carbohydrate moiety of lps ( o-antigen ) s1119.3 demonstrating that the common antigenic determinants ( hapten ) of b. abortus lps reacting with these precipitat... | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
238,
260
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
263,
269
]
} |
interactions of polymeric mcpc 870 and mopc 384 mouse iga myeloma proteins with a streptococcal cell wall tetraheteroglycan ( t4-antigen ) , salmonella tranoroa lipopolysaccharide ( lps ) , s. telaviv lps and its lipid a free polysaccharide were examined by the quantitative precipitin method . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
182,
185
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
213,
220
]
} |
possible applications include identification of b-cell precursors lacking conventional markes , a molecular classification of lymphomas and a precise distinction between monoclonal and polyclonal lymphoproliferative disorders . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
126,
135
]
} | {
"id": "C0024314",
"name": "lymphoproliferative",
"pos": [
196,
215
]
} |
metabolic control should achieve a glucose excretion of less than 5 % of the consumed carbohydrates , a 2-h postprandial blood sugar of less than 200 mg/dl ( 140-200 mg/dl ) and a hbalc-concentration below 8 % ( = less than + 3 sd ) . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
35,
42
]
} | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
121,
132
]
} |
the effect of l-ethionine , the ethyl analog of the essential amino acid methionine , on the sos system of escherichia coli was studied . | NA | {
"id": "C0002525",
"name": "essential amino acid",
"pos": [
52,
72
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
73,
83
]
} |
a class of arabinosyladenine ( araa ) -resistant mutants of baby hamster kidney ( bhk 21/c13 ) cells exhibits multiple phenotypes : resistance to araa and deoxyadenosine , extreme sensitivity to adenosine ( ado ) and varying degrees of deficiency in adenosine kinase ( ak ) activity . | NA | {
"id": "C0042646",
"name": "araa",
"pos": [
31,
35
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
250,
259
]
} |
trichomonad proteins present in cell-free supernatants from logarithmic phase cultures of a pathogenic strain of trichomonas vaginalis were detected with enzyme-linked immunosorbent assay employing antibody from mice and rabbit antisera . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
198,
206
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
228,
236
]
} |
in addition to blocking the dopamine reuptake mechanism , amphetamine also augments dopaminergic function by augmenting dopamine release directly into the synapse . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
84,
96
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
120,
128
]
} |
human tumour necrosis factor has about 30 % homology in its amino acid sequence with lymphotoxin , a lymphokine that has similar biological properties . | NA | {
"id": "C0024320",
"name": "lymphotoxin",
"pos": [
85,
96
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
101,
111
]
} |
a novel mammalian neuropeptide , the tachykinin substance k , is specified by a discrete genomic segment . | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
37,
47
]
} | {
"id": "C0038581",
"name": "substance k",
"pos": [
48,
59
]
} |
recombinant phage included those with a 9.5-kb proviral dna and viral dna permuted with respect to the single ecori site . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
56,
59
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
64,
73
]
} |
this blocking effect was specific , as other monoclonal antibodies -- such as antibody to histocompatibility locus antigen ( hla ) class ii or anti-t-cell natural killer ( tnk ) target -- directed at other surface structures strongly expressed on activated cultured t4+ cells , did not prevent lav infection . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
45,
55
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
78,
86
]
} |
metallothioneins ( mts ) , small cysteine-rich proteins , bind to and are inducible by heavy metals such as zinc , cadmium and copper . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
87,
99
]
} | {
"id": "C0043481",
"name": "zinc",
"pos": [
108,
112
]
} |
metallothioneins ( mts ) , small cysteine-rich proteins , bind to and are inducible by heavy metals such as zinc , cadmium and copper . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
87,
99
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
115,
122
]
} |
metallothioneins ( mts ) , small cysteine-rich proteins , bind to and are inducible by heavy metals such as zinc , cadmium and copper . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
87,
99
]
} | {
"id": "C0009968",
"name": "copper",
"pos": [
127,
133
]
} |
it was shown quantitatively that of the four ionic species of the ligands commonly present at physiological ph , the cation governs beta 2-adrenoceptor affinity . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
45,
50
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
117,
123
]
} |
the possibility that the yohimbine-induced increase in the da turnover rate was produced by a direct blockade of da autoreceptors , was investigated under conditions where influences other than those elicited via da autoreceptors are thought to be eliminated , i.e . in rats treated with reserpine or gamma-butyrolactone... | NA | {
"id": "C0724441",
"name": "induced",
"pos": [
35,
42
]
} | {
"id": "C0035179",
"name": "reserpine",
"pos": [
288,
297
]
} |
from the order of potency : cyclohexyladenosine greater than ( - ) phenylisopropyladenosine [ - ) pia ) greater than 5'-n-ethylcarboxamideadenosine ( neca ) greater than 2-chloradenosine greater than ( + ) phenylisopropyladenosine greater than adenosine , the inhibitory adenosine receptor may be classified as a1- ( r1-... | NA | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
67,
91
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
271,
280
]
} |
adenosine and 2-chloroadenosine were equipotent in producing a dose-dependent inhibition of the amplitude of the compound action potential . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
0,
9
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
14,
31
]
} |
at the highest concentration tested ( 1 mm ) adenosine and 2-chloroadenosine produced about 30 % decrease in the amplitude of the compound action potential . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
45,
54
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
59,
76
]
} |
bay k 8644 ( 1-100 nmol/l ) was less effective at reversing the effects of nisoldipine ( 10 nmol/l ) , a slowly dissociating dihydropyridine , than the effects of nifedipine . | NA | {
"id": "C0028116",
"name": "nisoldipine",
"pos": [
75,
86
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
125,
140
]
} |
bay k 8644 ( 1-100 nmol/l ) was less effective at reversing the effects of nisoldipine ( 10 nmol/l ) , a slowly dissociating dihydropyridine , than the effects of nifedipine . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
125,
140
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
163,
173
]
} |
effect of electroconvulsive treatment on cerebral opioid receptors in the rat : changes in delta but not mu receptors . | NA | {
"id": "C0034801",
"name": "opioid receptors",
"pos": [
50,
66
]
} | {
"id": "C0066908",
"name": "mu receptors",
"pos": [
105,
117
]
} |
an antiserum rich in antibodies to a format determinant of s82 was passed through each column , and , by means of affinity purification , two homogeneous populations of anti-format antibodies were obtained , each with a binding affinity of 1 x 10 ( 8 ) m-1 for s82 . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
3,
12
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
181,
191
]
} |
general aspects of metabolic features of the most prominent cns intermediate filament proteins , the 200,000 ( 200k ) , 150,000 ( 150k ) , and 70,000 ( 70k ) dalton proteins of the neuron , and the glial fibrillary acidic protein ( gfap ) have been explored using the incubated spinal cord slice from the rat . | NA | {
"id": "C0021769",
"name": "intermediate",
"pos": [
64,
76
]
} | {
"id": "C0017626",
"name": "glial fibrillary acidic protein",
"pos": [
198,
229
]
} |
the interaction was specific since neither basic protein , nor albumin bound to an affinity column consisting of bp bound to agarose . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
49,
56
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
63,
70
]
} |
the authors defined the morbidity index of late epilepsy ( mi ) on the ground of notified cases in the population aged over 20 years ( with first seizure past the age of 20 years ) comprising 228273 individuals ( 125453 living in towns and 102820 living in villages ) in the years 1979-1980 . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
48,
56
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
146,
153
]
} |
although there was no case of metastatic brain tumor having a dna histogram of primary tumor in the same case , dna patterns of metastatic brain tumors might be related to those of primary tumors because of the similarity of the histograms . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
60,
65
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
112,
115
]
} |
ontogenetic development of the pro-enkephalin b ( = pro-dynorphin ) opioid peptide system in the rat pituitary . | NA | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
56,
65
]
} | {
"id": "C0205753",
"name": "opioid peptide",
"pos": [
68,
82
]
} |
arterial plasma concentrations of unconjugated catecholamines increased simultaneously with the rise in blood pressure following gnrh injection : the half-maximal pressor dose of gnrh ( 0.1 nmol x kg-1 ) caused a 3-fold increase in plasma noradrenaline and a 20-fold increase in plasma adrenaline concentrations . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
239,
252
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
286,
296
]
} |
hormones and tumours in central nervous system ( cns ) : steroid receptors in primary spinal cord tumours . | NA | {
"id": "C0085136",
"name": "tumours",
"pos": [
13,
20
]
} | {
"id": "C0037930",
"name": "spinal cord tumours",
"pos": [
86,
105
]
} |
on the basis of the studies reported on steroid receptors in brain tumours , cytoplasmic and nuclear estrogen ( er ) and progesterone ( pr ) receptors have been examined in forty primary spinal cord tumours : fifteen neurinomas , three neurofibromas , nine meningiomas , nine ependymomas , two astrocytomas , one oligode... | NA | {
"id": "C0034840",
"name": "steroid receptors",
"pos": [
40,
57
]
} | {
"id": "C0034833",
"name": "progesterone",
"pos": [
121,
133
]
} |
intravenous administration of beta-carboline-3-carboxylate methyl ester ( beta-ccm ) produced convulsions at small doses ( 0.03 mg/kg ) in adult chickens , homozygous for the epileptic gene . | NA | {
"id": "C0036572",
"name": "convulsions",
"pos": [
94,
105
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
175,
184
]
} |
in unstressed rats , morphine , pentobarbital , diazepam and alprazolam were without effect on plasma norepinephrine ( ne ) and epinephrine ( e ) levels . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
102,
116
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
128,
139
]
} |
applied to [ leu ] enkephalin , the new methodology resulted in antisera of high affinity ( k eff 0.1 x 10 ( 12 ) m-1 ) which recognized only enkephalin-like pentapeptides . | NA | {
"id": "C0014294",
"name": "leu ] enkephalin",
"pos": [
13,
29
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
142,
152
]
} |
striatal met- and leu-enkephalin contents were determined after 1 , 3 , 6 , 9 and 12 months of treatment , and one week after the drug withdrawal following a 12-month treatment , enkephalin levels were significantly increased with slight fluctuations in some months and returned to normal one week after the last neurole... | NA | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
18,
32
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
179,
189
]
} |
our findings confirm previous observations that prolonged disturbances in functions of the dopaminergic mechanism result in specific disturbances in the endogenous opioid peptide content , release and biosynthesis , and demonstrate that enkephalins are one of the factors with take part in the mechanism of neuroleptic a... | NA | {
"id": "C0205753",
"name": "opioid peptide",
"pos": [
164,
178
]
} | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
237,
248
]
} |
in a group of 8 conscious dogs the octapeptide of cck was infused intravenously in its sulfated ( cck-8s ) or nonsulfated ( cck-8ns ) form and in addition the tetrapeptide of cck ( cck-4 ) was given at increasing infusion rates of 50 , 200 and 500 pmol/kg . h , respectively . | NA | {
"id": "C0037167",
"name": "octapeptide",
"pos": [
35,
46
]
} | {
"id": "C0008328",
"name": "cck",
"pos": [
181,
184
]
} |
although the lowest concentration of ethanol exerted no effect on 45ca2+ ion activity , an intermediate concentration caused mixed effects in either enhancing or suppressing the efflux into the perfusate of this cation . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
30,
33
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
212,
218
]
} |
ultrastructural immunocytochemical study of the dopaminergic innervation of the rat lateral septum with anti-dopamine antibodies . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
48,
60
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
109,
117
]
} |
the dopaminergic innervation of the rat lateral septum has been investigated at ultrastructural level by immunocytochemistry using the unlabelled peroxidase-anti-peroxidase method with anti-dopamine antibodies . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
4,
16
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
190,
198
]
} |
both crude brain membranes and a lentil lectin affinity purified brain glycoprotein fraction absorbed the antibody , suggesting that the antigen is a membrane bound glycoprotein . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
71,
83
]
} | {
"id": "C0025248",
"name": "membrane",
"pos": [
150,
158
]
} |
decreased gaba fluid levels have been identified in both severely epileptic patients and infants with febrile convulsions . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
66,
75
]
} | {
"id": "C0009952",
"name": "febrile convulsions",
"pos": [
102,
121
]
} |
six male graduate students , unrestricted in their lifestyle , collected their own urine over a seven-day period : it was analysed for cortisol , noradrenaline , adrenaline and dopamine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
146,
159
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
162,
172
]
} |
regression of hormone levels against self-assessed mood changes revealed correlations of ( 1 ) adrenaline accumulation with physical fatigue , ( 2 ) cortisol with alertness and ( 3 ) ratios of adrenaline , noradrenaline and dopamine with tenseness and irritability . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
95,
105
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
206,
219
]
} |
small cell carcinoma is just as operable as all other forms of bronchogenic carcinoma , if in addition chemotherapy and radiotherapy are administered . | NA | {
"id": "C0149925",
"name": "small cell carcinoma",
"pos": [
0,
20
]
} | {
"id": "C0007121",
"name": "bronchogenic carcinoma",
"pos": [
63,
85
]
} |
ischemic optic neuropathy , in its arteritic and idiopathic varieties , presents both diagnostic and therapeutic challenges to the clinician , specifically : the role of temporal artery biopsy in management of giant cell arteritis ; | NA | {
"id": "C0003860",
"name": "arteritic",
"pos": [
35,
44
]
} | {
"id": "C0039483",
"name": "giant cell arteritis",
"pos": [
210,
230
]
} |
as hydroxychloroquine and chloroquine appear to be better tolerated and less toxic than some other drugs used in the treatment of rheumatoid arthritis and systemic lupus erythematosus , there is a need for a simple , patient-administered test for early diagnosis of chloroquine retinopathy . | NA | {
"id": "C0020336",
"name": "hydroxychloroquine",
"pos": [
3,
21
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
266,
277
]
} |
a monoclonal antibody specific for neurofilaments ( antibody 4.3 f9 ) revealed , in comparison with normal controls , a preferential loss of large-type axons of the proximal segment of the orbital portion of the optic nerve as well as in the intracanalicular portion . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
2,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
52,
60
]
} |
afferent stimulation induced pain relief in acute oro-facial pain and its failure to induce sufficient pain reduction in dental and oral surgery . | NA | {
"id": "C0015468",
"name": "pain",
"pos": [
29,
33
]
} | {
"id": "C0040460",
"name": "pain",
"pos": [
103,
107
]
} |
they reviewed the literature on schistosomisis , fasciolasis , cestode infections ( hydatidoses and cysticercoses ) and nematode infections . | NA | {
"id": "C0007894",
"name": "cestode infections",
"pos": [
63,
81
]
} | {
"id": "C0013502",
"name": "hydatidoses",
"pos": [
84,
95
]
} |
these changes were similar to those found in non-pregnant sheep in response to sodium depletion or loading , with the additional finding of interstitial edema in the zona glomerulosa of sheep with twin fetuses . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
129,
136
]
} | {
"id": "C0013604",
"name": "interstitial edema",
"pos": [
140,
158
]
} |
the ontogeny of human antibody responses to pneumococcal polysaccharide antigens was studied by determining whether the age at immunization affects the level and/or immunoglobulin isotype of antibody produced . | NA | {
"id": "C0021017",
"name": "immunoglobulin isotype",
"pos": [
165,
187
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
191,
199
]
} |
since virtually no data were available on the rectal absorption profile of methadone in man , plasma concentrations of methadone were determined by means of hplc analysis after a single dose of 10 mg methadone hcl in a cross-over pilot study in five volunteers . | NA | {
"id": "C0025605",
"name": "methadone",
"pos": [
75,
84
]
} | {
"id": "C0721688",
"name": "methadone hcl",
"pos": [
200,
213
]
} |
purified e2 mrna was digested with rnase a or rnase t1 and the resulting oligonucleotides were resolved by two dimensional paper electrophoresis-homochromatography . | NA | {
"id": "C0014241",
"name": "rnase",
"pos": [
35,
40
]
} | {
"id": "C0018364",
"name": "rnase t1",
"pos": [
46,
54
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.