text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the right hand junction of the type i sequence with the unique dna is identical to the right hand junction of the type i sequences with rdna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
63,
66
]
} | {
"id": "C0012933",
"name": "rdna",
"pos": [
136,
140
]
} |
oriented dna films prepared by the wet-spinning technique have been complexed with several ligands : the anthracycline antibiotic violamycin bi , the dipeptide l-carnosine , and the oligopeptide antibiotic netropsin . | NA | {
"id": "C0012512",
"name": "dipeptide",
"pos": [
150,
159
]
} | {
"id": "C0007267",
"name": "carnosine",
"pos": [
162,
171
]
} |
in baby hamster kidney cells stably transformed with recombinant dna containing the human epsilon-globin gene and in cos 7 cells transiently transfected with dna containing the epsilon-globin gene , hypersensitive sites can be demonstrated . | NA | {
"id": "C0012931",
"name": "recombinant dna",
"pos": [
53,
68
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
158,
161
]
} |
in this gddna , the ( + ) and the ( shorter ) ( - ) strand carry different genetic markers in such a way , that a rigorous selection can be applied for phage carrying the markers of the ( - ) strand . | NA | {
"id": "C0017393",
"name": "genetic markers",
"pos": [
75,
90
]
} | {
"id": "C0005516",
"name": "markers",
"pos": [
171,
178
]
} |
for introduction of the mutation , a synthetic oligonucleotide with partial homology to a target site within the single stranded dna region is annealed to the gddna . | NA | {
"id": "C0012935",
"name": "single stranded dna",
"pos": [
113,
132
]
} | {
"id": "C0012854",
"name": "gddna",
"pos": [
159,
164
]
} |
at 4 weeks of age the effect of oil was not significant with 30 or 20 % dietary protein ( no measurements were made in chicks fed 35 or 25 % protein ) . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
72,
87
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
141,
148
]
} |
this applies to antimitochondria antibody type 3 ( anti m3 ) in the lupus-like syndrome caused by venocuran , to antimitochondria antibody type 6 ( anti m6 ) in iproniazide-induced hepatitis , to anti-insulin antibody found after treatment with methimazole , and to anti liver/kidney microsome antibody type 2 ( anti lkm... | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
33,
41
]
} | {
"id": "C0021644",
"name": "anti-insulin antibody",
"pos": [
196,
217
]
} |
in addition , we placed these upstream inserted aug codons into each of the three possible translation reading frames so that translation occurring in these frames terminates prior to , within , or downstream of the galk initiation codon , respectively . | NA | {
"id": "C0009221",
"name": "codons",
"pos": [
52,
58
]
} | {
"id": "C0242610",
"name": "initiation",
"pos": [
221,
231
]
} |
monoclonal antibodies specific for aflatoxin b1 , aflatoxin b2 , aflatoxin m1 , and the major aflatoxin-dna adducts were obtained following fusion of mouse sp-2 myeloma cells with spleen cells of mice immunized with aflatoxin b1 covalently bound to bovine gamma globulin . | NA | {
"id": "C0085181",
"name": "aflatoxin m1",
"pos": [
65,
77
]
} | {
"id": "C0001734",
"name": "aflatoxin",
"pos": [
216,
225
]
} |
mechanism of toxin secretion by vibrio cholerae investigated in strains harboring plasmids that encode heat-labile enterotoxins of escherichia coli . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
13,
18
]
} | {
"id": "C0014372",
"name": "enterotoxins",
"pos": [
115,
127
]
} |
if2 alpha contains two adjacent regions ( residues 104-155 and 167-214 ) that are rich in alanine and charged amino acids and that show striking periodicities in their sequences . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
90,
97
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
110,
121
]
} |
dna molecules created by fusing a 365-base-pair segment of yeast dna encoding the galactose-regulated upstream promoter element ( gal ) to a set of derivatives that systematically delete sequences upstream from the his3 gene are introduced in single copy back into the yeast genome precisely at the his3 locus and then a... | NA | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
0,
13
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
333,
334
]
} |
when an il-2-free source of bgdf was used with the antigenic stimulus , addition of r-il-2 did not augment the response , nor did removal of il-2 from the crude lymphokine mixture diminish the bgdf activity . | NA | {
"id": "C0021764",
"name": "il-2",
"pos": [
8,
12
]
} | {
"id": "C0021759",
"name": "il-2",
"pos": [
141,
145
]
} |
when an il-2-free source of bgdf was used with the antigenic stimulus , addition of r-il-2 did not augment the response , nor did removal of il-2 from the crude lymphokine mixture diminish the bgdf activity . | NA | {
"id": "C0021764",
"name": "il-2",
"pos": [
8,
12
]
} | {
"id": "C0021758",
"name": "bgdf",
"pos": [
193,
197
]
} |
the delta and gamma subunit genes are encoded by the same dna strand and are very closely linked , there being only 740 base pairs between the last codon of delta and the initiator codon of gamma . | NA | {
"id": "C0009221",
"name": "codon",
"pos": [
148,
153
]
} | {
"id": "C0242610",
"name": "initiator codon",
"pos": [
171,
186
]
} |
the amounts of prostaglandins ( pgf2 alpha and pge ) and cyclic gmp ( cgmp ) measured in the media were found to vary with the cycle in the ch dog . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
15,
29
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
47,
50
]
} |
and ( b ) naloxone at lower concentrations ( 3 x 10 ( -7 ) , 3 x 10 ( -6 ) , and 3 x 10 ( -5 ) m ) augmented the vasoconstrictor effects of epinephrine and norepinephrine without altering kcl- or serotonin-induced constriction . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
140,
151
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
156,
170
]
} |
naloxone 's augmenting effect on norepinephrine-induced constriction was abolished when the specimens were incubated with 10 ( -5 ) m normetanephrine , while naloxone ( 3 x 10 ( -5 ) m ) still augmented the constriction even when the specimens were incubated with 10 ( -5 ) m cocaine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
33,
47
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
134,
149
]
} |
mopidamole potentiated the growth inhibitory effect of hfif in cultures of es-1 malignant melanoma cells , lncap prostatic carcinoma cells , rt-4 transitional carcinoma cells , ht-29 colon adenocarcinoma cells and in diploid fibroblast cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
99,
104
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
225,
235
]
} |
administration of a benzodiazepine , chlordiazepoxide ( cdp ) , prior to exposure to inescapable shock prevented both the long-term analgesia and the shuttle-escape deficit typically observed following inescapable shock . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
20,
34
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
37,
53
]
} |
calcium antagonists , of which the best known are verapamil , nifedipine and diltiazem , are a powerful group of cardioactive agents with a clinical spectrum of indications rather similar to those of beta-adrenoceptor blockade , including angina of effort , angina at rest , hypertension and supraventricular tachycardia... | NA | {
"id": "C0002962",
"name": "angina of effort",
"pos": [
239,
255
]
} | {
"id": "C0002965",
"name": "angina at rest",
"pos": [
258,
272
]
} |
stress response was measured biochemically ( plasma concentrations of epinephrine , norepinephrine and dopamine ) , physiologically by monitoring heart rate and blood pressure and subjectively ( by visual analogue scales ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
70,
81
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
84,
98
]
} |
in addition this communication presents data indicating ( 1 ) wide variability in the extent of na+ adsorption among different isolated proteins and even among different samples of the same protein , ( 2 ) auto-cooperativity in the ph titration and na+ adsorption , and ( 3 ) selectivity of the liberated fixed anionic g... | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
311,
318
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
353,
357
]
} |
treatment of d rat with drugs that stimulate serotonergic neurons of receptors ( tryptophan , 5-hydroxytryptophan , quipazine , femoxetine ) resulted in d-s reversal . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
81,
91
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
94,
113
]
} |
these myopathies reveal a varying severity of a proximal , distal or generalized muscular involvement indicating a progressive myopathy or recurrent episodes of weakness , pain , cramps and stiffness combined with exercise . | NA | {
"id": "C0026848",
"name": "myopathy",
"pos": [
127,
135
]
} | {
"id": "C0026821",
"name": "cramps",
"pos": [
179,
185
]
} |
acute effects of naloxone and naltrexone , but lack of delayed effects , on exploratory behavior in the rat . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
17,
25
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
30,
40
]
} |
the opiate antagonists naloxone and naltrexone ( 0.5 and 2 mg/kg ) were administered once , 30 min before the first session . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
23,
31
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
36,
46
]
} |
during the initial 10 min of the first session naloxone and naltrexone decreased the number of head-poke responses without reducing locomotor activity and rearing . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
47,
55
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
60,
70
]
} |
the observation that both naloxone and naltrexone were effective in the present procedure suggests that the effects of naloxone and naltrexone reported here are a function of opiate antagonist properties of these drugs . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
26,
34
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
132,
142
]
} |
in order to investigate this hypothesis in relation to the hyperphagia produced by benzodiazepines , the effects of chlordiazepoxide were compared with those of the gaba agonists progabide and muscimol and the gaba antagonists picrotoxin and bicuculline . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
83,
98
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
116,
132
]
} |
hepatic tuberculosis was confirmed in 96 patients presenting with the features of liver disease , only 14 of whom had other concomitant hepatic pathology . | NA | {
"id": "C0041313",
"name": "hepatic tuberculosis",
"pos": [
0,
20
]
} | {
"id": "C0023895",
"name": "the",
"pos": [
119,
122
]
} |
thus , the half-life for the metabolism of methanethiol to sulfate was 1.21 hr and for the elimination of sulfate in the urine was 8.47 hr . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
29,
39
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
91,
102
]
} |
the plasma concentrations of glutathione and glutathione disulfide were measured in rats following the administration of diquat , metronidazole , nitrofurantoin , doxorubicin , dimethylnitrosamine or carbon tetrachloride . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
29,
40
]
} | {
"id": "C0061516",
"name": "glutathione disulfide",
"pos": [
45,
66
]
} |
[ 5-alpha steroid reductase and 17-beta steroid oxidoreductase activity in human fibroblasts . comparison between cells of normal individuals and patients with different types of male pseudohermaphroditism ] . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
81,
92
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
114,
119
]
} |
a drastic reduction in tissue noradrenaline , adrenaline , and dopamine levels occurred after sympathectomy , and fluorescence microscopy showed a complete loss of adrenergic nerve fibers . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
30,
43
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
46,
56
]
} |
significant elevations not only of coproporphyrin but also of some other porphyrins were found in many patients with liver disease . | NA | {
"id": "C0009988",
"name": "coproporphyrin",
"pos": [
35,
49
]
} | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
73,
83
]
} |
cell-free synovial fluid ( sf ) obtained from patients with rheumatoid arthritis contains a helper factor ( s ) capable of augmenting the generation of plaque-forming cells ( pfc ) in pokeweed mitogen ( pwm ) -stimulated normal peripheral blood mononuclear cells ( pbmc ) . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
134,
137
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
228,
262
]
} |
an increase in the level of adohcy was observed already after 1 h of incubation but was more pronounced after 4 h of preincubation with the adenosine derivatives . | NA | {
"id": "C0036001",
"name": "adohcy",
"pos": [
28,
34
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
140,
149
]
} |
hypercalcaemic patients could not be separated from normocalcaemic patients regarding any other determined biochemical variable , or regarding the incidence of osteonecrosis of weight-bearing joints , which was found in 18 % of transplanted patients , and which was the only cause of major symptomatic bone disease obser... | NA | {
"id": "C0029445",
"name": "osteonecrosis",
"pos": [
160,
173
]
} | {
"id": "C0005940",
"name": "of",
"pos": [
281,
283
]
} |
in a study of signs of progressive secondary hyperparathyroidism ( hpt ) in a random sample of patients with chronic renal disease , symptomatic bone disease occurred only in transplanted patients with osteonecroses of major joints . | NA | {
"id": "C0005940",
"name": "bone disease",
"pos": [
145,
157
]
} | {
"id": "C0029445",
"name": "osteonecroses",
"pos": [
202,
215
]
} |
according to this linear disease model , a psychopathological syndrome , expanded with course of illness over a specified period of time ( small disease entity ) and with the etiopathogenesis ( etiopathogenetical-syndromatological disease entity ) , can progress to the full disease entity . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
62,
70
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
275,
282
]
} |
the treatment of narcolepsy comprises advice in appropriate daily regimen , nutrition and vocational orientation as well as medication by stimulating agents for hypersomnolence and by tricyclic drugs for cataplexy . | NA | {
"id": "C0027404",
"name": "narcolepsy",
"pos": [
17,
27
]
} | {
"id": "C0007384",
"name": "cataplexy",
"pos": [
204,
213
]
} |
substantial differences were found both within populations according to gender and age , and between populations with respect to : the extent of death from violence , the proportion such deaths were of all deaths and the ratio of male to female mortality from this cause . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
72,
78
]
} | {
"id": "C0086582",
"name": "male",
"pos": [
240,
244
]
} |
blood plasma renin activity , blood adrenaline and noradrenaline concentrations , and the kallikrein-kinin system were studied in 48 patients with chronic renal failure ( crf ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
36,
46
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
51,
64
]
} |
[ cardiomyopathies , nonspecific myocarditis and alcoholic heart lesions ( data from the clinical study of 100 patients ) ] . | NA | {
"id": "C0878544",
"name": "cardiomyopathies",
"pos": [
2,
18
]
} | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
33,
44
]
} |
of these , 14 patients had hypertrophic cardiomyopathy ( cmp ) of the obstructive type , 21 hypertrophic non-obstructive cmp ( symmetrical , apical , septal ) , 15 congestive cmp , 34 nonspecific myocarditis , and 16 alcoholic lesion of the heart . | NA | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
40,
54
]
} | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
196,
207
]
} |
study of blood progesterone and diurnal urine pregnanediol revealed that progesterone level substantially increased in the initial stage of cor pulmonale formation ( in respiratory failure without heart decompensation ) . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
15,
27
]
} | {
"id": "C0033004",
"name": "pregnanediol",
"pos": [
46,
58
]
} |
meanwhile as heart insufficiency and pulmonary hypertension in patients with chronic nonspecific lung diseases augmented , blood progesterone and excretion of pregnanediol dramatically fell . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
129,
141
]
} | {
"id": "C0033004",
"name": "pregnanediol",
"pos": [
159,
171
]
} |
since the condensed preskeletal rudiments are spared by the haemorrhage , resorption of the hematoma results in limb defects which may be limited to the soft tissues . | NA | {
"id": "C0019080",
"name": "haemorrhage",
"pos": [
60,
71
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
92,
100
]
} |
an episode of exercise induced asthma will usually be followed by a period during which further exercise will not induce asthma . | NA | {
"id": "C0004099",
"name": "exercise induced asthma",
"pos": [
14,
37
]
} | {
"id": "C0004096",
"name": "asthma",
"pos": [
121,
127
]
} |
as the duration of bronchoconstriction induced by inhaled histamine phosphate is greater than five minutes , a study was carried out to determine whether this leads to a cumulative effect when histamine is inhaled at five minute intervals as in standardised procedures . | NA | {
"id": "C0062740",
"name": "histamine phosphate",
"pos": [
58,
77
]
} | {
"id": "C0019588",
"name": "histamine",
"pos": [
193,
202
]
} |
when conventional forms of treatment such as grooming , skin-hygienic measures and antibiotics fail or relapses occur , immunotherapy with a staphylococcal vaccine or toxoid might be considered . | NA | {
"id": "C0042210",
"name": "vaccine",
"pos": [
156,
163
]
} | {
"id": "C0040555",
"name": "toxoid",
"pos": [
167,
173
]
} |
in studies with experimental animals it was shown alpha-toxoid was superior to other staphylococcal toxoids or vaccines in preventing skin lesions . | NA | {
"id": "C0040555",
"name": "toxoid",
"pos": [
56,
62
]
} | {
"id": "C0038167",
"name": "staphylococcal toxoids",
"pos": [
85,
107
]
} |
in studies with experimental animals it was shown alpha-toxoid was superior to other staphylococcal toxoids or vaccines in preventing skin lesions . | NA | {
"id": "C0040555",
"name": "toxoid",
"pos": [
56,
62
]
} | {
"id": "C0042210",
"name": "vaccines",
"pos": [
111,
119
]
} |
further , the study demonstrates the utility of comparative population analysis in identifying and characterizing alleles encoded by the hla-d region and provides additional evidence of heterogeneity within the family of serologically-defined hla-dr haplotypes . | NA | {
"id": "C0019754",
"name": "hla-d",
"pos": [
137,
142
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
243,
249
]
} |
polyclonal and monoclonal antibodies against rat liver nuclear lamins have been used to evaluate the immunological cross-reactivity of lamins with a given antibody in a variety of animal and plant cells . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
15,
36
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
155,
163
]
} |
the binding of 125i-tyr8-bradykinin was reversible and saturable , and demonstrated high specificity for tyr8-bradykinin , bradykinin and lys-bradykinin , but was not displaced by unrelated peptides angiotensin i , angiotensin ii , arg8-vasopressin and oxytocin . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
25,
35
]
} | {
"id": "C0022474",
"name": "lys-bradykinin",
"pos": [
138,
152
]
} |
we present a fully automated high-pressure liquid chromatographic ( hplc ) assay for simultaneous quantitation of five antiepileptic drugs [ ethosuximide ( es ) , primidone , phenobarbital , phenytoin , and carbamazepine ] and their major metabolites [ phenylethylmalondiamide ( pema ) , carbamazepine-10,11-dihydro-10,1... | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
163,
172
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
175,
188
]
} |
estimated on the basis of the values of buoyant density ( p ) and the melting temperature ( tmelt . ) the content of guanine-cytosine pairs ( gc pairs ) in the viral dna varies from 61 up to 65 mol % , and in the insect cell dna -- from 38 up to 40 mol % . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
160,
169
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
225,
228
]
} |
the enzyme of mitochondrial fraction shows the activity at low ( 0,03-0.05 mm ; isoenzyme i ) and high ( 5 mm ; isoenzyme ii ) concentrations of the substrate . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
4,
10
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
112,
121
]
} |
[ the health status of the youngest school children . a study of 486 children from the kindergarten and first classes in the district of karlebo during the 1982-83 school year ] . | NA | {
"id": "C0728836",
"name": "of",
"pos": [
20,
22
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
69,
77
]
} |
short-lived radioactive carbon , 11c , ( t 1/2 = 20 min ) was incorporated into an essential amino acid [ 11c-methyl ] -l-methionine , to form a true biological amino acid tracer with external detectability . | NA | {
"id": "C0002525",
"name": "essential amino acid",
"pos": [
83,
103
]
} | {
"id": "C0025646",
"name": "l-methionine",
"pos": [
120,
132
]
} |
in addition to congenital ocular defects , other abnormalities may be manifest including multiple system involvement with embryonic mortality , fetal death , mummification , abortion , dysmaturity , premature birth , full-term stillbirth , or nonviable or viable neonate . | NA | {
"id": "C0015927",
"name": "fetal death",
"pos": [
144,
155
]
} | {
"id": "C0595939",
"name": "stillbirth",
"pos": [
227,
237
]
} |
circulating concentrations of 25-hydroxyvitamin d2 ( 25ohd2 ) and 25-hydroxyvitamin d3 ( 25ohd3 ) provide , respectively , a measure of the contributions of the diet and sunshine to the overall vitamin d status . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
66,
86
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
89,
95
]
} |
ultrastructurally the lacunar matrix contained bundles of fine fibrils without the typical collagen periodicity which might indicate synthesis of a defective procollagen . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
91,
99
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
158,
169
]
} |
these findings are discussed in relation to the 'no reflow ' phenomenon after ischemia in general . | NA | {
"id": "C0232347",
"name": "no reflow",
"pos": [
49,
58
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
78,
86
]
} |
electrophoretic size analyses of chicken dna digested with restriction enzymes indicate that dna fragments totaling over 50 kb hybridize with viral ets dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
41,
44
]
} | {
"id": "C0012939",
"name": "viral",
"pos": [
142,
147
]
} |
polyacrylamide gel electrophoresis of complementary ( c ) dnas transcribed in the presence of dideoxynucleotides reveals that the sgrnas from type and nd18 have almost identical sequences for at least 160 nt adjacent to the 5 ' side of the poly ( a ) region . | NA | {
"id": "C0599651",
"name": "dideoxynucleotides",
"pos": [
94,
112
]
} | {
"id": "C0028630",
"name": "nt",
"pos": [
214,
216
]
} |
the results in this study suggest that using monospecific antisera other than anti-igg alone , one can detect additional antibodies involved in the immune destruction of platelets . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
58,
66
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
121,
131
]
} |
malignant ventricular arrhythmias are a key element in sudden cardiac death and prevention of sudden death remains to be a major challenge for cardiologists . | NA | {
"id": "C0085298",
"name": "sudden cardiac death",
"pos": [
55,
75
]
} | {
"id": "C0011071",
"name": "sudden death",
"pos": [
94,
106
]
} |
the glutathione conjugates are further metabolized by cleavage of the glycine and glutamate residues to give cysteine conjugates or n-acetylcysteine conjugates by acetylation in mammals . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
109,
117
]
} | {
"id": "C0001047",
"name": "n-acetylcysteine",
"pos": [
132,
148
]
} |
dna reannealing studies demonstrated that lyme disease spirochetes represent a new species of borrelia , exhibiting a 31-59 percent dna homology with the three species of north american borreliae . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
0,
3
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
193,
194
]
} |
during the course of the 20th century , the impact of sex differences in mortality from the infectious and parasitic diseases has declined , as has the contribution from maternal mortality . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
92,
102
]
} | {
"id": "C0030499",
"name": "parasitic diseases",
"pos": [
107,
125
]
} |
systematic relativization of individual protein clearances by reference to albumin ( or transferrin ) clearance requires the application of special calculations to find out the regression coefficients relevant to functional diagnosis . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
40,
47
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
75,
82
]
} |
moreover , they suggest that both hyperinsulinemia and high concentrations of counterregulatory substances might play a role in the pathogenesis of insulin resistance in subjects suffering from chronic liver disease . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
34,
50
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
148,
166
]
} |
although the significance of these findings is far from clear , the occurrence of small vessel hemoconcentration in male patients with diabetes mellitus may be relevant to the pathophysiology of vascular complications of diabetes . | NA | {
"id": "C0011849",
"name": "diabetes mellitus",
"pos": [
135,
152
]
} | {
"id": "C0342257",
"name": "of",
"pos": [
218,
220
]
} |
the effect of daily injections of d-ser- ( tbu ) 6-lrh-ea10 ( gnrh analogue ( gnrh-a ) 100 micrograms sc ) on serum testosterone ( t ) , 17 alpha-hydroxyprogesterone ( 17ohp ) and oestradiol-17 beta ( e2 ) was studied in 4 men . | NA | {
"id": "C0045010",
"name": "17 alpha-hydroxyprogesterone",
"pos": [
137,
165
]
} | {
"id": "C0020387",
"name": "17ohp",
"pos": [
168,
173
]
} |
the intratesticular concentrations of progesterone , 20 alpha-dihydroprogesterone , 17 alpha-hydroxyprogesterone and testosterone were measured both basally and after lh stimulation . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
38,
50
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
53,
81
]
} |
our data support the hypothesis that from local mesenchymal cells originates a pool of poorly differentiated reticulum cells that can give rise to stromal stationary reticulum cells ( myofibroblast-like cells , fibroblast-like cells , pericyte-like cells and dendritic cells ) . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
187,
197
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
269,
274
]
} |
maternal dietary fat did not influence fetal weight , sartorius muscle weight , length , composition , cellularity or satellite cell content . | NA | {
"id": "C0751992",
"name": "fetal weight",
"pos": [
39,
51
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
71,
77
]
} |
the virulence-enhancing interaction of baker 's yeast and different iron preparations ( ferric ammonium citrate and iron dextran ) was tested in mice challenged with salmonella typhi and vibrio cholerae ( inaba and ogawa ) strains . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
68,
72
]
} | {
"id": "C0022092",
"name": "iron dextran",
"pos": [
116,
128
]
} |
size of the hematoma and the presence of blood in the csf did not represent evident signs in differentiating benign from unfavourable brainstem hematomas or hemorrhages . | NA | {
"id": "C0018944",
"name": "hematomas",
"pos": [
144,
153
]
} | {
"id": "C0019080",
"name": "hemorrhages",
"pos": [
157,
168
]
} |
in 4 patients , the effect was compared with that of methohexital , another barbiturate known to have excitatory effects upon epileptic activity . | NA | {
"id": "C0025668",
"name": "methohexital",
"pos": [
53,
65
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
76,
87
]
} |
in the hippocampi of epileptic patients immunoreactive astrocytes were found , the number of which was increasing with the severity of the manifest convulsions . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
21,
30
]
} | {
"id": "C0036572",
"name": "convulsions",
"pos": [
148,
159
]
} |
by their s-100 reactivity and their distribution fsc are comparable to glial cells of the central and schwann and satellite cells of the peripheral nervous system ( pns ) as well as to supportive cells in neuroendocrine organs and related tumors ( e.g. , pheochromocytomas , paragangliomas , carcinoids ) . | NA | {
"id": "C0031511",
"name": "pheochromocytomas",
"pos": [
255,
272
]
} | {
"id": "C0030421",
"name": "paragangliomas",
"pos": [
275,
289
]
} |
the transplants retained the histological and immunohistochemical picture of the original tissue and maintained synthesis of human chorionic gonadotropin ( hcg ) , pregnancy-specific beta 1-glycoprotein ( sp1 ) , gnrh and placental proteins pp5 , pp11 and pp12 for 5 weeks . | NA | {
"id": "C0033002",
"name": "pregnancy-specific beta 1-glycoprotein",
"pos": [
164,
202
]
} | {
"id": "C0032974",
"name": "placental proteins",
"pos": [
222,
240
]
} |
electron-microscopically two main cell types were identified : myofibroblasts and fibroblasts , the former dominating in cellular areas , the latter dominating in collagenized areas . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
66,
77
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
121,
129
]
} |
the majority of the carcinomas were localized to the palate and 3/4 of these were verrucous carcinomas , with or without anaplastic transformation to infiltrating squamous cell carcinomas . | NA | {
"id": "C0007097",
"name": "carcinomas",
"pos": [
20,
30
]
} | {
"id": "C0206706",
"name": "verrucous carcinomas",
"pos": [
82,
102
]
} |
a general theory for the precipitin reaction is formulated , assuming it to be a three-stage process : 1st stage formation of immune complexes , 2nd stage precipitation due to coalescence of antibody-rich immune complexes , and 3rd stage fc-mediated immune precipitation . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
191,
199
]
} | {
"id": "C0003313",
"name": "immune",
"pos": [
250,
256
]
} |
acetazolamide inhibits nahco3 and most of the remaining nacl reabsorption in the proximal tubules ( bicarbonate-dependent reabsorption ) but raises distal transcellular nacl reabsorption . | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
23,
29
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
100,
111
]
} |
an unexpected finding was that muscle lactate after contraction to fatigue was lower ( 30 % , p less than 0.01 ) and muscle ph was higher ( 6.80 +/- 0.06 vs. 6.61 +/- 0.12 , p less than 0.01 ) in the trained subjects than in the sedentary controls . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
14,
21
]
} | {
"id": "C0015672",
"name": "fatigue",
"pos": [
67,
74
]
} |
the ratio dopamine/noradrenaline in renal venous plasma ( approximately 0.15 ) was not influenced by varying the rns parameters but was significantly enhanced ( to about 0.25 ) by pretreatment with guanethidine according to a procedure previously used to demonstrate renal dopaminergic vasodilation . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
10,
18
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
273,
285
]
} |
the high ratio of dopamine/noradrenaline in kidney tissue ( with a preferential distribution of dopamine to the cortex ) and the dopamine outflow to renal venous plasma during rns support the existence of specific dopaminergic nerves in the dog kidney . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
18,
26
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
214,
226
]
} |
on the other hand , ionic ( doc ) and anionic ( sds ) detergents strongly increased the uptake of na and other amines into pl . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
20,
25
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
38,
45
]
} |
the 30-min accumulation of 3h-labelled branched-chain amino acids was ostensibly higher than the increase in their total concentrations in incubated slices , which apparently bespeaks lively homoexchange of endogenous intracellular and labelled extracellular amino acids . | NA | {
"id": "C0002521",
"name": "branched-chain amino",
"pos": [
39,
59
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
259,
270
]
} |
the brain bcaa contents became higher , and the brain methionine and tyrosine levels and the ratio of glutamine to glutamic acid in the brain diminished after administering the bcaa-enriched solution . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
102,
111
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
115,
128
]
} |
glucosamine and muramic acid and also significant amounts of glycine together with three major amino acids ; | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
61,
68
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
95,
106
]
} |
anorexia nervosa is an eating disorder which affects people of all classes and ages but in particular adolescent girls . | NA | {
"id": "C0003125",
"name": "anorexia nervosa",
"pos": [
0,
16
]
} | {
"id": "C0013473",
"name": "eating disorder",
"pos": [
23,
38
]
} |
at posttreatment , reductions were achieved in weight , percent overweight , and skinfold , with greater changes observed for the eight-week group than for the four-week group . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
47,
53
]
} | {
"id": "C0497406",
"name": "overweight",
"pos": [
64,
74
]
} |
ct scan and renal arteriography pointed out right renal cyst , but the tumor was separate from the right kidney at operation . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
56,
60
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
71,
76
]
} |
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