text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
congenital mesoblastic nephroma ( cmn ) is an unusual renal tumor , similar in some respects to wilms ' tumor and reported only in infants . | NA | {
"id": "C0022665",
"name": "renal tumor",
"pos": [
54,
65
]
} | {
"id": "C0027708",
"name": "wilms",
"pos": [
96,
101
]
} |
prostatic tissue levels and serum levels of ceftizoxime ( czx ) , cefoperazone ( cpz ) and cefotaxime ( ctx ) , after intravenous administration were studied in 82 patients with prostatic hypertrophy , who underwent transurethral surgery . | NA | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
44,
55
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
91,
101
]
} |
cholesteryl ester storage disease and wolman disease : phenotypic variants of lysosomal acid cholesteryl ester hydrolase deficiency . | NA | {
"id": "C0008384",
"name": "cholesteryl ester storage disease",
"pos": [
0,
33
]
} | {
"id": "C0043208",
"name": "wolman disease",
"pos": [
38,
52
]
} |
the lysosomal enzyme responsible for cholesteryl ester hydrolysis , acid cholesteryl ester hydrolase , or acid lipase ( e.c.3.1.1.13 ) plays an important role in cellular cholesterol metabolism . | NA | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
37,
54
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
171,
182
]
} |
loss of the activity of this enzyme in tissues of individuals with both wolman disease and cholesteryl ester storage disease is believed to play a causal role in these conditions . | NA | {
"id": "C0043208",
"name": "wolman disease",
"pos": [
72,
86
]
} | {
"id": "C0008384",
"name": "cholesteryl ester storage",
"pos": [
91,
116
]
} |
the objectives of our studies were not only to directly compare and contrast the clinical features of wolman disease and cholesteryl ester storage disease but also to determine the reasons ( s ) for the varied phenotype expression of acid cholesteryl ester hydrolase deficiency . | NA | {
"id": "C0043208",
"name": "wolman disease",
"pos": [
102,
116
]
} | {
"id": "C0008384",
"name": "cholesteryl ester storage disease",
"pos": [
121,
154
]
} |
in addition , fibroblasts from both wolman disease and cholesteryl ester storage disease were able to utilize exogenously supplied enzyme , suggesting that neither disease was due to defective enzyme delivery by the mannose-6-phosphate receptor pathway . | NA | {
"id": "C0043208",
"name": "wolman disease",
"pos": [
36,
50
]
} | {
"id": "C0008384",
"name": "cholesteryl ester storage disease",
"pos": [
55,
88
]
} |
coculture and cell fusion of fibroblasts from wolman disease and cholesteryl ester storage disease subjects did not lead to correction of the enzyme deficiency , indicating that these disorders are allelic . | NA | {
"id": "C0043208",
"name": "wolman disease",
"pos": [
46,
60
]
} | {
"id": "C0008384",
"name": "cholesteryl ester storage disease",
"pos": [
65,
98
]
} |
the human monomeric enzyme was detected in chinese hamster-human cell hybrids by a thermal denaturation assay that selectively inactivated the chinese hamster isozyme , while the thermostable human enzyme retained activity . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
159,
166
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
198,
204
]
} |
abnormalities in the cell-division cycle in roberts syndrome fibroblasts : a cellular basis for the phenotypic characteristics ? | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
61,
72
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
77,
85
]
} |
a modification of the emit-tox qualitative serum barbiturate assay ( syva company , palo alto , ca ) was evaluated for measuring pentobarbital concentrations . | NA | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
49,
60
]
} | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
129,
142
]
} |
specificity for pentobarbital with respect to other barbiturates and assay interference from other drugs were evaluated in vitro . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
16,
29
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
52,
64
]
} |
pooled human serum that contained low , medium , and high concentrations of gentamicin sulfate ( approximately 2.5 , 5 , and 10 micrograms/ml of gentamicin ) were analyzed for actual gentamicin concentration by fia . | NA | {
"id": "C0546866",
"name": "gentamicin sulfate",
"pos": [
76,
94
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
183,
193
]
} |
the interactions of cefmenoxime with beta-lactamases in comparison with cefotaxime , moxalactam , cefoperazone , and ceftazidime have been determined . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
20,
31
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
72,
82
]
} |
within these data , the cephalosporins could be classified into three groups : ( 1 ) those with high affinity for the cephalosporinases and very poor affinity for the penicillinase ( cefmenoxime , cefotaxime , and moxalactam ) ; | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
183,
194
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
197,
207
]
} |
the frequency of painful crises , leg ulceration , aseptic necrosis of bone and acute chest syndrome was similar in hbs-beta o + alpha-thalassemia patients and controls with sickle cell anemia ( hbss ) , hbss-alpha-thalassemia and hbs-beta o-thalassemia . | NA | {
"id": "C0742343",
"name": "acute chest syndrome",
"pos": [
80,
100
]
} | {
"id": "C0002895",
"name": "sickle cell anemia",
"pos": [
174,
192
]
} |
prospective management of exstrophy of the cloaca and myelocystocele following prenatal ultrasound recognition of neural tube defects in identical twins . | NA | {
"id": "C0025312",
"name": "myelocystocele",
"pos": [
54,
68
]
} | {
"id": "C0027794",
"name": "neural tube defects",
"pos": [
114,
133
]
} |
the capacity of lung explant cultures to synthesize collagen can be estimated by determining the content of [ 3h ] hydroxyproline in protein following incubation with [ 3h ] proline . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
115,
129
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
174,
181
]
} |
the technique requires acid hydrolysis followed by quantitative separation of hydroxyproline from proline for scintillation counting and is often restricted to methods that can accommodate large samples because of relatively low specific radioactivity . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
78,
92
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
98,
105
]
} |
under isocratic conditions hydroxyproline is completely resolved from proline with quantitative recovery of the 3h cpm applied to the column . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
27,
41
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
70,
77
]
} |
a fast-heating probe and chemical ionization have been used to obtain mass spectra of the synthetic glycerophospholipids 1,2-diacyl-sn-glycero-3-phosphocholine , 1,2-diacyl-sn-glycero-3-phosphoethanolamine , and 1-monoacyl-2-lyso-sn-glycero-3-phosphocholine . | NA | {
"id": "C0162448",
"name": "glycerophospholipids",
"pos": [
100,
120
]
} | {
"id": "C0031618",
"name": "phosphoethanolamine",
"pos": [
186,
205
]
} |
a quantitative determination by capillary gas-liquid chromatography of neutral and amino sugars ( as o-methyloxime acetates ) , and a study on hydrolytic conditions for glycoproteins and polysaccharides in order to increase sugar recoveries . | NA | {
"id": "C0002531",
"name": "amino sugars",
"pos": [
83,
95
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
224,
229
]
} |
a single hydrolytic step for carbohydrate-containing biological material ( less than or equal to 2.5 x 10 ( -3 ) m sugar solution in 4 n trifluoroacetic acid at 125 degrees c for 1 h ) has been developed , and results have been compared with those obtained with standard hydrolytic conditions in order to ensure complete... | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
115,
120
]
} | {
"id": "C0002531",
"name": "amino sugars",
"pos": [
332,
344
]
} |
flavin mononucleotide sensitized and polyoxyethylene ( 20 ) sorbitan trioleate micelle-enhanced gas/solution chemiluminescence for direct continuous monitoring of sulfur dioxide in the atmosphere . | NA | {
"id": "C0017110",
"name": "gas",
"pos": [
96,
99
]
} | {
"id": "C0038777",
"name": "sulfur dioxide",
"pos": [
163,
177
]
} |
the observed elements include sodium , potassium , magnesium , calcium , phosphorus , iron , manganese , zinc , copper , boron , silicon , thallium , vanadium , aluminium , mercury and gold . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
13,
21
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
73,
83
]
} |
the present study is devoted to the biliary excretion of some beta-lactam antibiotics ( 6 derived from the penicillin group : penicillin g , ampicillin , metampicillin , carbenicillin , mezlocillin , apalcillin and 9 from the cephalosporin group : cephalothin , cephaloridine , cephacetrile , cefalexin , cefazolin , cef... | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
107,
119
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
157,
167
]
} |
the present study is devoted to the biliary excretion of some beta-lactam antibiotics ( 6 derived from the penicillin group : penicillin g , ampicillin , metampicillin , carbenicillin , mezlocillin , apalcillin and 9 from the cephalosporin group : cephalothin , cephaloridine , cephacetrile , cefalexin , cefazolin , cef... | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
107,
119
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
170,
183
]
} |
the present study is devoted to the biliary excretion of some beta-lactam antibiotics ( 6 derived from the penicillin group : penicillin g , ampicillin , metampicillin , carbenicillin , mezlocillin , apalcillin and 9 from the cephalosporin group : cephalothin , cephaloridine , cephacetrile , cefalexin , cefazolin , cef... | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
141,
151
]
} | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
186,
197
]
} |
the present study is devoted to the biliary excretion of some beta-lactam antibiotics ( 6 derived from the penicillin group : penicillin g , ampicillin , metampicillin , carbenicillin , mezlocillin , apalcillin and 9 from the cephalosporin group : cephalothin , cephaloridine , cephacetrile , cefalexin , cefazolin , cef... | NA | {
"id": "C3536856",
"name": "cephalosporin",
"pos": [
226,
239
]
} | {
"id": "C0007727",
"name": "cephaloridine",
"pos": [
262,
275
]
} |
the present study is devoted to the biliary excretion of some beta-lactam antibiotics ( 6 derived from the penicillin group : penicillin g , ampicillin , metampicillin , carbenicillin , mezlocillin , apalcillin and 9 from the cephalosporin group : cephalothin , cephaloridine , cephacetrile , cefalexin , cefazolin , cef... | NA | {
"id": "C3536856",
"name": "cephalosporin",
"pos": [
226,
239
]
} | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
278,
290
]
} |
the present study is devoted to the biliary excretion of some beta-lactam antibiotics ( 6 derived from the penicillin group : penicillin g , ampicillin , metampicillin , carbenicillin , mezlocillin , apalcillin and 9 from the cephalosporin group : cephalothin , cephaloridine , cephacetrile , cefalexin , cefazolin , cef... | NA | {
"id": "C0007735",
"name": "cephalothin",
"pos": [
248,
259
]
} | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
278,
290
]
} |
the present study is devoted to the biliary excretion of some beta-lactam antibiotics ( 6 derived from the penicillin group : penicillin g , ampicillin , metampicillin , carbenicillin , mezlocillin , apalcillin and 9 from the cephalosporin group : cephalothin , cephaloridine , cephacetrile , cefalexin , cefazolin , cef... | NA | {
"id": "C0007716",
"name": "cefalexin",
"pos": [
293,
302
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
344,
352
]
} |
these copolymers contain the element silicon as siloxane bonds in side branches of the main polymer chain , which is made of carbon-to-carbon bonds . | NA | {
"id": "C0013879",
"name": "element",
"pos": [
29,
36
]
} | {
"id": "C0007009",
"name": "carbon",
"pos": [
135,
141
]
} |
we also studied liver tissue and serum from a patient with haemochromatosis and from a child with iron overload of unknown origin . | NA | {
"id": "C0018995",
"name": "haemochromatosis",
"pos": [
59,
75
]
} | {
"id": "C0282193",
"name": "iron overload",
"pos": [
98,
111
]
} |
the effect of 2 % cholesterol feeding on changes throughout postnatal development of total , free , and esterified cholesterol in neonatal chick liver and kidneys was studied . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
18,
29
]
} | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
104,
126
]
} |
the increase observed in the hepatic cholesterol content after supplementation of the diet with 2 % cholesterol was mainly due to the accumulation of esterified cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
37,
48
]
} | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
150,
172
]
} |
small but significant differences were also found in the esterified cholesterol content in kidneys between control and cholesterol-fed animals . | NA | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
57,
79
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
119,
130
]
} |
igg antibodies to either whole organisms or to crf were found in sera obtained from patients with chronic mucocutaneous candidiasis ( cmcc ) or digestive candidiasis , as well as in healthy control sera . | NA | {
"id": "C0006845",
"name": "chronic mucocutaneous candidiasis",
"pos": [
98,
131
]
} | {
"id": "C0006840",
"name": "candidiasis",
"pos": [
154,
165
]
} |
igm anti-ssf in the absence of igg anti-ssf were found in sera of patients with recent digestive candidiasis , and low levels of igm and igg ab were detected in sera of cmcc patients . | NA | {
"id": "C0006840",
"name": "candidiasis",
"pos": [
97,
108
]
} | {
"id": "C0006845",
"name": "cmcc",
"pos": [
169,
173
]
} |
we evaluated the in vitro synergistic activity at clinically attainable concentrations of combinations of aminoglycoside and beta-lactam antibiotics against 30 gentamicin-resistant clinical isolates of gram-negative bacilli . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
106,
120
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
160,
170
]
} |
growth of the strains in the presence of 50 u of polymyxin b per ml was characterized by a doubling time of 120 min , whereas the doubling time in the absence of polymyxin was 60 min . | NA | {
"id": "C0032535",
"name": "polymyxin b",
"pos": [
49,
60
]
} | {
"id": "C0032539",
"name": "polymyxin",
"pos": [
162,
171
]
} |
we postulate that these alterations are part of an adaptive response by the strains to the presence of polymyxin in the growth medium and reflect a resistance mechanism distinct from the mechanism affording polymyxin b resistance when these strains are initially exposed to the antibiotic . | NA | {
"id": "C0032539",
"name": "polymyxin",
"pos": [
103,
112
]
} | {
"id": "C0032535",
"name": "polymyxin b",
"pos": [
207,
218
]
} |
the addition of the aminoglycoside gentamicin to intact cells in the presence of npn led to a shift in the fluorescence emission maximum from 460 to 420 nm . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
20,
34
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
35,
45
]
} |
four patients infected with pseudomonas aeruginosa were treated with the triple therapy of carboxypenicillin ( carbenicillin or ticarcillin ) , aminoglycoside ( gentamicin or tobramycin ) , and rifampin . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
144,
158
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
161,
171
]
} |
comparative activities of the beta-lactamase inhibitors ytr 830 , sodium clavulanate , and sulbactam combined with amoxicillin or ampicillin . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
115,
126
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
130,
140
]
} |
the antimicrobial activities of bmy-28142 , cefbuperazone ( bmy-25182 ; formerly t-1982 ) , and cefpiramide ( wy-44635 ; formerly sm-1652 ) were compared with those of cefmenoxime , cefoperazone , cefotaxime , ceftizoxime , and moxalactam . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
168,
179
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
197,
207
]
} |
the antimicrobial activities of bmy-28142 , cefbuperazone ( bmy-25182 ; formerly t-1982 ) , and cefpiramide ( wy-44635 ; formerly sm-1652 ) were compared with those of cefmenoxime , cefoperazone , cefotaxime , ceftizoxime , and moxalactam . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
197,
207
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
210,
221
]
} |
however , bmy-28142 , cefbuperazone , cefmenoxime , cefotaxime , ceftizoxime , and moxalactam were equivalent in activity and rate of killing against members of the family enterobacteriaceae . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
38,
49
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
52,
62
]
} |
however , bmy-28142 , cefbuperazone , cefmenoxime , cefotaxime , ceftizoxime , and moxalactam were equivalent in activity and rate of killing against members of the family enterobacteriaceae . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
52,
62
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
65,
76
]
} |
the isolates exhibited a bimodal distribution for several heavy metals including mercury , whose resistance is often plasmid mediated . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
58,
70
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
81,
88
]
} |
cephalexin , cephradine , and cefsulodin were the least active , with mics of 25 to 125 micrograms/ml . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
0,
10
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
13,
23
]
} |
the in vitro activities of the new spectinomycin analog u-63366 and four new quinolone derivatives , rosoxacin , norfloxacin , ofloxacin , and ciprofloxacin , were compared with those of penicillin , tetracycline , thiamphenicol , cefotaxime , ceftriaxone , and spectinomycin against 222 beta-lactamase-negative and 25 b... | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
231,
241
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
244,
255
]
} |
beta-lactamase production and mic determinations for penicillin , methicillin , and cephalothin were assessed for 67 strains of staphylococcus saprophyticus and correlated with results of disk diffusion susceptibility testing . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
53,
63
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
66,
77
]
} |
criteria presently used to define susceptibility of staphylococcus aureus to penicillin and oxacillin by disk diffusion are inappropriate for s. saprophyticus . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
77,
87
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
92,
101
]
} |
the susceptibility of 46 clinical isolates of bacteroides bivius to amoxicillin , cefotaxime , cefoxitin , ceftizoxime , cephaloridine , cephalothin , moxalactam , penicillin g , amoxicillin plus clavulanic acid in a ratio of 2:1 , carbenicillin , cefamandole , and ceftazidime was determined by an agar dilution techniq... | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
82,
92
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
107,
118
]
} |
the susceptibility of 46 clinical isolates of bacteroides bivius to amoxicillin , cefotaxime , cefoxitin , ceftizoxime , cephaloridine , cephalothin , moxalactam , penicillin g , amoxicillin plus clavulanic acid in a ratio of 2:1 , carbenicillin , cefamandole , and ceftazidime was determined by an agar dilution techniq... | NA | {
"id": "C0007727",
"name": "cephaloridine",
"pos": [
121,
134
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
266,
277
]
} |
the susceptibility of 46 clinical isolates of bacteroides bivius to amoxicillin , cefotaxime , cefoxitin , ceftizoxime , cephaloridine , cephalothin , moxalactam , penicillin g , amoxicillin plus clavulanic acid in a ratio of 2:1 , carbenicillin , cefamandole , and ceftazidime was determined by an agar dilution techniq... | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
164,
176
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
232,
245
]
} |
in vitro and in vivo antibacterial activities of mt-141 , a new semisynthetic cephamycin , compared with those of five cephalosporins . | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
78,
88
]
} | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
119,
133
]
} |
the in vitro effect of three cephalosporins ( cefodizime , cefotaxime , and ceftizoxime ) on the growth of the following lymphocytes or their derivatives was tested : l 5178y mouse lymphoma cells , molt-4 cells , and murine splenic lymphocytes . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
59,
69
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
76,
87
]
} |
however , molt-4 cell growth was significantly stimulated by 0.3 to 20 microm cefotaxime and cefodizime but was not influenced by ceftizoxime . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
78,
88
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
130,
141
]
} |
there was , however , a significant correlation between change in mood and change in weight , with weight loss being associated with improved mood state and weight gain with increased disturbance . | NA | {
"id": "C0005911",
"name": "change in weight",
"pos": [
75,
91
]
} | {
"id": "C0043094",
"name": "weight gain",
"pos": [
157,
168
]
} |
a variety of substituted matrices were synthesized using d- or dl-phenylglycine , norleucine , ampicillin , or amoxycillin as ligands , all of which retained penicillin acylase at high concentrations of ammonium sulfate or sodium sulfate . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
95,
105
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
111,
122
]
} |
the relative cross-reactivity of each toxin ( relative to afm1 ) with amw-1 , as determined by the amount of aflatoxin necessary to cause 50 % inhibition of enzyme activity , was 12 , greater than 40 , 12 , and greater than 40 for b1 , b2 , g1 , and g2 , respectively . | NA | {
"id": "C0085181",
"name": "afm1",
"pos": [
58,
62
]
} | {
"id": "C0001734",
"name": "aflatoxin",
"pos": [
109,
118
]
} |
menadione was found to cause a dose-dependent decrease in intracellular glutathione ( gsh ) level by three different mechanisms : ( a ) oxidation of gsh to glutathione disulfide ( gssg ) accounted for 75 % of the total gsh loss ; | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
180,
184
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
219,
222
]
} |
l-aspartate semialdehyde , an amino acid analog of l-homoserine , proved to be an alternative substrate of homoserine kinase ( km = 0.68 mm ) , and was subsequently used as a probe of its kinetic mechanism . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
30,
40
]
} | {
"id": "C0019892",
"name": "homoserine",
"pos": [
107,
117
]
} |
a mixed-function oxidase mechanism , similar to the biliverdin-forming reaction catalyzed by animal cell-derived microsomal heme oxygenase , was indicated by requirements for o2 and a reduced pyridine nucleotide . | NA | {
"id": "C0020364",
"name": "mixed-function oxidase",
"pos": [
2,
24
]
} | {
"id": "C0018969",
"name": "heme",
"pos": [
124,
128
]
} |
the group-specific polysaccharide of the group b streptococcus was isolated by nitrous acid extraction followed by gel filtration on sepharose 6b and chromatography on deae-bio-gel a . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
19,
33
]
} | {
"id": "C0036681",
"name": "sepharose",
"pos": [
133,
142
]
} |
each material isolated from insulin-treated human placental plasma membranes and mononuclear cells shared a number of important characteristics of putative second messengers of insulin action as follows : ( i ) heat and acid stability ; | NA | {
"id": "C0795635",
"name": "insulin",
"pos": [
28,
35
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
177,
184
]
} |
naf-activated preparations were also subjected to gel filtration in the presence of chaps , in which case both the catalytic activity and g/f emerged in the activated state . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
0,
3
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
140,
141
]
} |
naf and guanine nucleotide sensitivity could be reconstituted in nonactivated preparations of c by g/f in the presence of naf or guanylylimidodiphosphate . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
2,
3
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
122,
125
]
} |
a preparation containing both factor a and factor b did not protect the following key carbohydrate-metabolizing enzymes from thermal inactivation : glucokinase , glucose-6-phosphatase ( solubilized or nonsolubilized forms ) , pyruvate kinase , glucose-6-p dehydrogenase , muscle-type phosphofructokinase , or the minor l... | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
112,
119
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
345,
352
]
} |
the activation by pyridoxal-5'-p is specific , as 1 mm pyridoxal , pyridoxine , pyridoxine-5'-p , pyridoxamine , pyridoxamine-5'-p , or 4-pyridoxic acid did not stimulate the pentapeptide carboxylation rate . | NA | {
"id": "C0034266",
"name": "pyridoxal",
"pos": [
18,
27
]
} | {
"id": "C0034272",
"name": "pyridoxine",
"pos": [
80,
90
]
} |
similarly , anion-exchange chromatographic analysis of the water-soluble products released from [ 32p ] pip indicated that inorganic phosphate was the sole 32p-labeled product . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
12,
17
]
} | {
"id": "C0031603",
"name": "inorganic phosphate",
"pos": [
123,
142
]
} |
these results suggest that thylakoid-bound ribosomes are the main sites of synthesis of thylakoid proteins and stromal-free ribosomes are that of stromal proteins , and that thylakoids and stroma contain mrnas for the stromal and the thylakoid proteins , respectively , in a form not functioning in the chloroplasts . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
75,
84
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
244,
252
]
} |
the structures of the enzyme-substrate compounds of peroxidases and catalase determined by x-ray absorption spectroscopy are presented . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
52,
63
]
} | {
"id": "C0007367",
"name": "catalase",
"pos": [
68,
76
]
} |
the oligosaccharide moieties of components b and c are the disaccharide , n-acetyl-d-mannosaminuronyl- ( 1,3 ) -n-acetyl-d-glucosamine , and the trisaccharide , n-acetyl-d-mannosaminuronyl- ( 1,4 ) -n-acetyl-d-mannosaminuronyl++ +- ( 1 , 3 ) -n-acetyl-d-glucosamine , respectively , as determined by the complete degrada... | NA | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
4,
19
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
59,
71
]
} |
the oligosaccharide moieties of components b and c are the disaccharide , n-acetyl-d-mannosaminuronyl- ( 1,3 ) -n-acetyl-d-glucosamine , and the trisaccharide , n-acetyl-d-mannosaminuronyl- ( 1,4 ) -n-acetyl-d-mannosaminuronyl++ +- ( 1 , 3 ) -n-acetyl-d-glucosamine , respectively , as determined by the complete degrada... | NA | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
4,
19
]
} | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
145,
158
]
} |
in normal skin , cytokeratin polypeptides are expressed in different cell-type-specific patterns , in the keratinocytes of the different epidermal cell strata as well as in different lateral epithelial domains . | NA | {
"id": "C0007634",
"name": "cell-type",
"pos": [
69,
78
]
} | {
"id": "C0022567",
"name": "different",
"pos": [
173,
182
]
} |
a number of vitamin a analogs ( retinoids ) were used to manipulate the growth of epidermal keratinocytes in culture . | NA | {
"id": "C0042839",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
32,
41
]
} |
the retinoids used were the tmmp analog of ethyl retinoate ( ro 10-9359 ) , 13-cis retinoic acid , all trans retinoic acid and retinol ( trans ) . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
4,
13
]
} | {
"id": "C0022265",
"name": "13-cis retinoic acid",
"pos": [
76,
96
]
} |
uptake , elimination , and metabolism of 14c-picric acid and 14c-picramic acid in the american oyster ( crassostrea virginica ) . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
9,
20
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
27,
37
]
} |
the effects of cu 32-085 and bromocriptine on dose-response curves to sympathomimetic agents ( adrenaline , noradrenaline , methoxamine and clonidine ) , intravenously administered , were also studied . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
95,
105
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
108,
121
]
} |
cu 32-085 and bromocriptine reduced the pressor effect of adrenaline , noradrenaline and methoxamine and the hypotensive action of clonidine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
58,
68
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
71,
84
]
} |
a group of 23 consecutive patients with isolated mitral regurgitation confirmed by angiography , 8 of whom had normal and 15 abnormal coronary arteriographies , were compared with a control group of 27 subjects without valvular heart disease ( normal coronary arteriography in 7 cases , abnormal coronary arteriography i... | NA | {
"id": "C0026266",
"name": "mitral regurgitation",
"pos": [
49,
69
]
} | {
"id": "C0018824",
"name": "valvular heart disease",
"pos": [
219,
241
]
} |
the isolate oxidized elemental sulphur , thiosulphate and tetrathionate to sulphate in vitro in carbon-deficient medium , and also oxidized elemental sulphur to sulphate when inoculated into autoclaved soil supplemented with sulphur . | NA | {
"id": "C0039950",
"name": "thiosulphate",
"pos": [
41,
53
]
} | {
"id": "C0038720",
"name": "sulphate",
"pos": [
161,
169
]
} |
the isolate oxidized elemental sulphur , thiosulphate and tetrathionate to sulphate in vitro in carbon-deficient medium , and also oxidized elemental sulphur to sulphate when inoculated into autoclaved soil supplemented with sulphur . | NA | {
"id": "C0007009",
"name": "carbon",
"pos": [
96,
102
]
} | {
"id": "C0013879",
"name": "elemental",
"pos": [
140,
149
]
} |
the cytoplasm of the interstitial cells showed a structure similar to that of fibroblasts , and contained small numbers of lipid droplets . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
78,
89
]
} |
the present findings suggest that the interstitial cells are fibroblastic in nature and belong to the vitamin-a storing cell system , and that the wandering cells are macrophages derived from hematogenous monocytes . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
61,
73
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
157,
162
]
} |
although the initial time-course was different between butadiene monoxide and ethylene oxide ( with a high initial increase of ethylene oxide and a subsequent decrease ) an analysis at steady-state ( plateau concentrations ) revealed that only 29 % of the amounts of both epoxides which in theory are formed as primary m... | NA | {
"id": "C0015087",
"name": "ethylene oxide",
"pos": [
78,
92
]
} | {
"id": "C0014630",
"name": "epoxides",
"pos": [
272,
280
]
} |
cell survival after the combined action of manganese ( mncl2 ) and x-rays in synchronized chinese hamster cells . | NA | {
"id": "C0024706",
"name": "manganese",
"pos": [
43,
52
]
} | {
"id": "C0065642",
"name": "mncl2",
"pos": [
55,
60
]
} |
the pharmacokinetics of clofibric acid ( cpib , the active metabolite of clofibrate ) has been studied in two species of non-human primate after administration by two routes at three dose levels . | NA | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
24,
38
]
} | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
73,
83
]
} |
similar ic50 's and ic90 's ( concentrations causing 50 and 90 % inhibition ) were found for sisomicin , dibekacin , gentamicin , tobramycin , kanamycin b and netilmicin . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
93,
102
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
117,
127
]
} |
similar ic50 's and ic90 's ( concentrations causing 50 and 90 % inhibition ) were found for sisomicin , dibekacin , gentamicin , tobramycin , kanamycin b and netilmicin . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
93,
102
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
159,
169
]
} |
erythromycin estolate ( 0.5 mm ) , but not erythromycin base and erythromycin ethylsuccinate , induced 100 % cell death after 60 min incubation , and caused maximal inhibition of mitochondrial and microsomal ca2+ sequestration activities at 0.1 mm concentration . | NA | {
"id": "C0014806",
"name": "erythromycin base",
"pos": [
43,
60
]
} | {
"id": "C0014810",
"name": "erythromycin ethylsuccinate",
"pos": [
65,
92
]
} |
ester-sulphate contents ranged from 2.5 to 5.3 per cent with a higher value of 14.0 per cent being obtained for the most anionic fraction . | NA | {
"id": "C0038720",
"name": "sulphate",
"pos": [
6,
14
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
121,
128
]
} |
whey protein ( the non-phosphorylated protein group of bovine milk ) also at 2 per cent ( w/v ) in the drinking water produced a smaller reduction and only of fissure caries . | NA | {
"id": "C0078479",
"name": "whey protein",
"pos": [
0,
12
]
} | {
"id": "C0026138",
"name": "protein",
"pos": [
38,
45
]
} |
in the limit-dilution cultures of ly 2+ t cells the lgl originate from the single precursor cell and not from the irradiated filler cells . | NA | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
82,
96
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
132,
137
]
} |
promoting effect of beer and ethanol on anti-tumour cytotoxicity : unaffected growth of a transplantable rat tumour . | NA | {
"id": "C0004922",
"name": "beer",
"pos": [
20,
24
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
29,
36
]
} |
the effects of beer and alcohol ( 4.8 % ethanol v/v ) were studied on ( i ) the growth of a syngeneic colonic carcinoma transplantable in male d/a rats , ( ii ) levels of blood b and t-lymphocyte classes , ( iii ) antibody-dependent cellular cytotoxicity ( adcc ) , and ( iv ) direct lymphocyte anti-tumour cytotoxicity ... | NA | {
"id": "C0004922",
"name": "beer",
"pos": [
15,
19
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
40,
47
]
} |
beer and alcohol had no effect on tumour growth , but led to significant increases in non-specific anti-tumour cytotoxicity in the levels of blood lymphocytes labelled by the monoclonal antibody ox/8 ( cytotoxic/suppressor cells ) and in the levels of total t-lymphocytes ; | NA | {
"id": "C0004922",
"name": "beer",
"pos": [
0,
4
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
9,
16
]
} |
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