text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
proinsulin is converted to insulin during the maturation of secretory vesicles by the action of two proteases and conversion is inhibited by ionophores that disrupted intracellular h+ gradients . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
0,
10
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
27,
34
]
} |
since the concentration of anti-proinsulin igg binding in secretory vesicles is inversely proportional to the conversion of proinsulin to insulin , we were able to determine that maturing secretory vesicles had to reach a critical ph before proinsulin conversion occurred . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
35,
42
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
241,
251
]
} |
cultured human embryonic lung fibroblasts were used as a model to study the effects of transforming growth factor-beta ( tgf beta ) on the plasminogen activator ( pa ) activity released by nontumorigenic cells into the culture medium . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
30,
41
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
204,
209
]
} |
i.e. , heparan sulfate pg , the minor labeled component ( 15 % ) , remained pericellular while chondroitin sulfate ( cs ) pg , the predominately labeled pg ( 85 % ) , was associated with collagen fibrils as `` '' trails '' '' of 50-60-nm particles when viewed by scanning electron microscopy . | NA | {
"id": "C0033689",
"name": "chondroitin sulfate",
"pos": [
95,
114
]
} | {
"id": "C0033692",
"name": "pg",
"pos": [
153,
155
]
} |
it is phosphorylated in the presence of phorbol ester ( phorbol-12-o-tetradecanoylphorbol-13-acetate ) and its phosphorylation requires ca2+ ; | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
40,
53
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
64,
100
]
} |
the presence of cdna , encoding the t-pa signal peptide preceding the remaining portion of t-pa , suffices to achieve secretion of ( mutant ) t-pa into the medium . | NA | {
"id": "C0032144",
"name": "t-pa",
"pos": [
36,
40
]
} | {
"id": "C0032143",
"name": "t-pa",
"pos": [
142,
146
]
} |
deleting specific segments of t-pa h-chain cdna and subsequent transient expression in mouse ltk- cells of t-pa deletion-mutant proteins did not affect the formation of a stable complex between mutant t-pa and pai . | NA | {
"id": "C0032143",
"name": "t-pa",
"pos": [
30,
34
]
} | {
"id": "C0032144",
"name": "t-pa",
"pos": [
201,
205
]
} |
in the case of fibroblasts , pni- [ 125i ] -thrombin complexes that form in solution bind to the cells as a consequence of a receptor-mediated clearance process [ low et al , proc natl acad sci usa 78:2340 , 1981 ] . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
15,
26
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
97,
102
]
} |
a gas chromatographic technique is described for measuring various volatile sulphur compounds ( h2s , cos , cs2 , thiols , sulphides , disulphides ) in air at the parts per trillion level . | NA | {
"id": "C0038776",
"name": "sulphur compounds",
"pos": [
76,
93
]
} | {
"id": "C0038734",
"name": "thiols",
"pos": [
114,
120
]
} |
the separations were achieved by reversed-phase chromatography ( separon si c18 ) using methanol , methanol-water , methanol-0.1 m formic acid and ethanol-0.01 m aqueous phosphoric acid mixtures as mobile phases . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
88,
96
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
147,
154
]
} |
analysis of trichothecene mycotoxins in human blood by capillary column gas chromatography-ammonia chemical ionization mass spectrometry . | NA | {
"id": "C0017110",
"name": "gas",
"pos": [
72,
75
]
} | {
"id": "C0002607",
"name": "ammonia",
"pos": [
91,
98
]
} |
capillary column gas chromatography-ammonia chemical ionization mass spectrometry was found to be an excellent technique for the trace detection and identification of underivatized trichothecene mycotoxins . | NA | {
"id": "C0017110",
"name": "gas",
"pos": [
17,
20
]
} | {
"id": "C0002607",
"name": "ammonia",
"pos": [
36,
43
]
} |
separation of furosemide , phenylbutazone and oxyphenbutazone in plasma by direct injection onto internal surface reversed-phase columns with systematic optimization of selectivity . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
27,
41
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
46,
61
]
} |
ion pairing using either anionic or cationic surfactants was possible in the presence of the non-ionic surfactants . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
0,
3
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
25,
32
]
} |
the resulting per-o-acetyl carboxypentafluorobenzyl esters provided excellent negative-ion mass spectra with intense and diagnostic anions . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
87,
90
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
132,
138
]
} |
determination of digoxin , digoxigenin and dihydrodigoxigenin in urine by extraction , derivatization and high-performance liquid chromatography . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
17,
24
]
} | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
50,
61
]
} |
ovulation induction with human menopausal gonadotropin compared to human urinary follicle-stimulating hormone results in a significant shift in follicular fluid androgen levels without discernible differences in granulosa-luteal cell function . | NA | {
"id": "C0025326",
"name": "human menopausal gonadotropin",
"pos": [
25,
54
]
} | {
"id": "C0524639",
"name": "human urinary",
"pos": [
67,
80
]
} |
these findings raise the questions of whether maternal smbp levels influence the amount of igf-i available for the fetal-placental unit and whether igf-ii participates in glucose homeostasis in the fetus . | NA | {
"id": "C0037657",
"name": "igf-i",
"pos": [
91,
96
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
148,
154
]
} |
we developed a highly sensitive and specific assay for hcg using monoclonal antibodies ( mabs ) directed against a 37-amino acid synthetic polypeptide analogous to the carboxyl-terminus ( ctp ) of beta hcg . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
55,
58
]
} | {
"id": "C0106132",
"name": "beta hcg",
"pos": [
197,
205
]
} |
we compared the gnrh agonist [ 6-d- ( 2-naphthyl ) alanine ] gnrh acetate ( nafarelin , syntex ) administered as a single sc injection of 0.2 microgram/kg to gnrh infused iv in a dose of 2 micrograms/kg x h for 3 h and assessed the response of plasma steroid intermediates in estradiol ( e2 ) biosynthesis . | NA | {
"id": "C0064906",
"name": "nafarelin",
"pos": [
76,
85
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
158,
162
]
} |
although serum lh and fsh levels increased to similar peaks 3 h after commencing gnrh and nafarelin testing , they rose faster ( p less than 0.01 at 1 h ) and remained elevated longer ( p less than 0.05 at 24 h ) after nafarelin administration . | NA | {
"id": "C0023610",
"name": "gnrh",
"pos": [
81,
85
]
} | {
"id": "C0064906",
"name": "nafarelin",
"pos": [
219,
228
]
} |
however , plasma e2 increased later after nafarelin , but not after gnrh , rising from a baseline level of 30 +/- 6 ( +/- sem ) to 115 +/- 13 pg/ml at 24 h ( p less than 0.001 ) . | NA | {
"id": "C0064906",
"name": "nafarelin",
"pos": [
42,
51
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
68,
72
]
} |
the greater effectiveness of nafarelin than gnrh in stimulating e2 secretion appears to be related to the more prolonged gonadotropin response . | NA | {
"id": "C0064906",
"name": "nafarelin",
"pos": [
29,
38
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
44,
48
]
} |
to further elucidate the site of action of opioids on the pituitary-adrenal axis , we studied the effect of d-ala2 , mephe4 , met- ( o ) enkephalin-ol ( sandoz , fk 33-824 ) on plasma acth and beta-endorphin immunoreactivity and serum cortisol in 7 normal subjects and 11 patients with cushing 's syndrome ( cushing 's d... | NA | {
"id": "C0001622",
"name": "cushing 's disease",
"pos": [
308,
326
]
} | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
371,
390
]
} |
peripheral blood mononuclear cells from patients with acquired immune deficiency syndrome ( aids ) and aids-related complex ( arc ) , asymptomatic homosexuals , and healthy heterosexuals were analyzed for the proportions and numbers of leu 7+ cells and double-labeled leu 2+7+ cells and for the natural killer functions ... | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
0,
34
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
277,
282
]
} |
it is proposed that clinical features of prefrontal syndromes need not imply the presence of selective structural or biochemical damage to prefrontal cortex , and that a structurally diffuse cns disease often masquerades as a selective frontal-lobe disease . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
52,
61
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
249,
256
]
} |
sodium dodecyl sulfate-polyacrylamide gel electrophoresis and isoelectric focusing gel banding patterns , in conjunction with protein and carbohydrate assays and lectin binding studies , confirmed that this antigen is a highly glycosylated glycoprotein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
126,
133
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
162,
168
]
} |
the lower limit of sensitivity of the assay was about 10 pg of protein as determined with purified influenza a nucleoprotein expressed by recombinant dna . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
63,
70
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
111,
124
]
} |
the sensitivity and specificity of the elisa with whole-cell and the lps-i antigens in the detection of phase-specific antibody revealed that avirulent phase ii cells induced an immune response to phase i antigenic epitopes . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
75,
83
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
215,
223
]
} |
the decrease was independent of serum titers of immunoglobulin g to purified viral antigen but did correlate with decreased proliferation of t lymphocytes to virus and myelin antigens . | NA | {
"id": "C0003342",
"name": "viral antigen",
"pos": [
77,
90
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
175,
183
]
} |
mitoxantrone , a new antineoplastic anthracenedione drug , suppressed the development of experimental allergic encephalomyelitis ( eae ) in rats when administered during the incubation period . | NA | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
0,
12
]
} | {
"id": "C0003174",
"name": "anthracenedione",
"pos": [
36,
51
]
} |
we postulate that the partially purified antigenic determinant is a glioma-associated determinant of highly restricted expression and is presented in hapten-carrier form by the glioma cells . | NA | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
41,
62
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
150,
156
]
} |
the ontogenic switch from fetal to adult hemoglobin could result from discontinuous events , such as replacement of fetal erythroid progenitor cells by adult ones , or gradual modulation of the hemoglobin program of a single progenitor cell pool . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
41,
51
]
} | {
"id": "C0019016",
"name": "hemoglobin",
"pos": [
194,
204
]
} |
lpl activity was removed from php by elution through immunoaffinity columns containing antibodies to apolipoprotein ( apo ) b and apo e . | NA | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
101,
115
]
} | {
"id": "C0003595",
"name": "apo",
"pos": [
130,
133
]
} |
since lipoproteins in php have undergone prior in vivo lipolysis , lpl activity in php may be bound to remnants of chylomicrons and very low density lipoproteins . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
6,
18
]
} | {
"id": "C0023825",
"name": "very low density",
"pos": [
132,
148
]
} |
the interaction of factor xiia with factor xi was investigated using two monoclonal antibodies , one ( 3cl ) directed against the heavy chain of factor xia and the other ( 5f4 ) against its light chain . | NA | {
"id": "C0015522",
"name": "factor xi",
"pos": [
19,
28
]
} | {
"id": "C0015524",
"name": "factor xia",
"pos": [
145,
155
]
} |
radioreceptor assay for insulin using guinea pig kidney membrane revealed that the binding activities of the normal component insulin , the abnormal component insulin and her pancreatic insulin containing both components were 100 , 5 , and 50 % of standard human insulin , respectively . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
24,
31
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
257,
270
]
} |
the biological activities of the normal component , the abnormal component and her pancreatic insulin to stimulate glucose oxidation in rat adipocytes were found to be 100 , 8 , and 60 % of standard human insulin , respectively . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
94,
101
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
199,
212
]
} |
since dietary protein increases urinary dopamine ( da ) excretion in animals , this study was undertaken to assess the role of da production in the acute changes in renal function following protein ingestion in man . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
6,
21
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
190,
197
]
} |
samples were subjected to crossed immunoelectrophoresis into homologous antiserum through an intermediate gel containing antibody to whole human serum to screen out serum derived components . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
72,
81
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
121,
129
]
} |
x resolves as two bands on sodium dodecyl sulphate-polyacrylamide gel electrophoresis ( sds-page ) with molecular weights of 81 k and 89 k and its major antigenic epitope is associated with disulphide bonds . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
153,
162
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
163,
170
]
} |
for this purpose , 36 pairs of contralateral periodontal pockets in 10 subjects with moderately advanced periodontitis were assessed for the degree of gingival inflammation , probing pocket depths , bleeding on probing , attachment levels and the amount of supragingival plaque . | NA | {
"id": "C0031094",
"name": "periodontal pockets",
"pos": [
45,
64
]
} | {
"id": "C0031099",
"name": "periodontitis",
"pos": [
105,
118
]
} |
doxycycline is a synthetic tetracycline compound whose main advantages over tetracycline hydrochloride are increased oral absorption , prolonged serum half-life and decreased gastrointestinal side-effects . | NA | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
27,
39
]
} | {
"id": "C0546879",
"name": "tetracycline hydrochloride",
"pos": [
76,
102
]
} |
in order to identify the source of cortical afferents , injections of retrograde tracers such as wheat germ agglutinin conjugated with horseradish peroxidase ( wga-hrp ) , or the fluorescent substances fast blue or nuclear yellow , were placed in different parts of the parahippocampal cortex . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
135,
157
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
160,
167
]
} |
the development of projections from somatic motor-sensory areas of neocortex to the diencephalon and brainstem was studied by using the orthograde transport of wheat germ agglutinin conjugated to horseradish peroxidase ( wga-hrp ) in a series of pouch-young opossums . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
196,
218
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
221,
228
]
} |
we correlated the level of vitiligo antibodies to the extent of depigmentation in thirty-two patients with vitiligo . | NA | {
"id": "C0162835",
"name": "depigmentation",
"pos": [
64,
78
]
} | {
"id": "C0042900",
"name": "vitiligo",
"pos": [
107,
115
]
} |
these results suggest that there is a relation between the incidence and level of vitiligo antibodies and the extent of depigmentation in vitiligo . | NA | {
"id": "C0162835",
"name": "depigmentation",
"pos": [
120,
134
]
} | {
"id": "C0042900",
"name": "vitiligo",
"pos": [
138,
146
]
} |
in this study , the differences in lesion remineralization and fluoride uptake after brushing with a 300 ppm f or a 1000 ppm f dentifrice ( as naf ) were investigated . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
63,
71
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
143,
146
]
} |
the present study can not support the presumption that the fluoride content of regular naf dentifrices can be lowered to 300 ppm f without undesirable effects on lesion arrest and remineralization . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
59,
67
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
87,
90
]
} |
single vessel disease was more common in group i ( aneurysm ) compared with groups ii and iii ( no aneurysm ) ( chi 2 ( 4 ) = 12.8 ; probability value equal to 0.012 ) . | NA | {
"id": "C0042373",
"name": "vessel disease",
"pos": [
7,
21
]
} | {
"id": "C0002940",
"name": "aneurysm",
"pos": [
99,
107
]
} |
the intracoronary administration of 3 mg isosorbide dinitrate produced a 24.7 +/- 11 % increase in coronary diameter ( p = ns versus pre- and postaspirin isosorbide in group 1b ) . | NA | {
"id": "C0022252",
"name": "isosorbide dinitrate",
"pos": [
41,
61
]
} | {
"id": "C0022251",
"name": "isosorbide",
"pos": [
154,
164
]
} |
the types of arrhythmia induced on day 24 were sustained ventricular tachycardia with a mean cycle length of 207 ms in six cases ( five monomorphic , one polymorphic ) , and ventricular fibrillation in three cases . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
13,
23
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
174,
198
]
} |
marked fetal bradycardia in the midtrimester of pregnancy is shown for the first time to be caused by transducer pressure on the maternal abdominal wall . | NA | {
"id": "C0032980",
"name": "midtrimester",
"pos": [
32,
44
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
48,
57
]
} |
in patients with extensive myocardial infarction , particularly anterior infarction , moderate intensity anticoagulation started soon after hospital admission reduces the rate of embolism . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
27,
48
]
} | {
"id": "C0340293",
"name": "anterior infarction",
"pos": [
64,
83
]
} |
atherosclerosis complicated by thromboembolism is the main cause of obstructive arterial disease in the legs . | NA | {
"id": "C0003850",
"name": "atherosclerosis",
"pos": [
0,
15
]
} | {
"id": "C0003838",
"name": "obstructive",
"pos": [
68,
79
]
} |
in the crohn 's disease leucocytes , incorporation of both labelled fatty acids into the phosphatidylcholine fraction was significantly lower than in controls , whereas the amount of both fatty acids remaining in the leucocytes as free fatty acids was increased by 70 % . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
68,
79
]
} | {
"id": "C0015688",
"name": "free fatty",
"pos": [
231,
241
]
} |
subsequently , she developed urticaria , angioedema , and respiratory and systemic symptoms on contact with potatoes , ingestion of potatoes , and exposure to cooking potatoes or potato pollen . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
29,
38
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
41,
51
]
} |
a total of 20 different preparations were studied for protein and carbohydrate content , presence of endotoxins , mycotoxins , and hemolytic toxins . | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
114,
124
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
141,
147
]
} |
prepregnancy weight status and weight gain during pregnancy are major independent variables associated with infant birth weight . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
13,
19
]
} | {
"id": "C0005612",
"name": "infant birth weight",
"pos": [
108,
127
]
} |
multiple regression analysis revealed that the influence of prenatal weight gain and birth weight varied depending on prepregnancy weight status . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
85,
97
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
131,
137
]
} |
dye reagent containing 0.5 % phenol gave optimal colour yield with most of the proteins investigated and an improved assay response of ovalbumin , ribonuclease , lysozyme , insulin , pepsin and chymotrypsinogen-a relative to bovine albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
79,
87
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
232,
239
]
} |
dye reagent containing 0.5 % phenol gave optimal colour yield with most of the proteins investigated and an improved assay response of ovalbumin , ribonuclease , lysozyme , insulin , pepsin and chymotrypsinogen-a relative to bovine albumin . | NA | {
"id": "C0029923",
"name": "ovalbumin",
"pos": [
135,
144
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
232,
239
]
} |
we have examined the acute ( 0-3 h ) effect of intracisternally administered 5,7-dihydroxytryptamine ( dht ) and 6-hydroxydopamine ( 6-ohda ) on blood pressure , heart rate , renal nerve activity , plasma adrenaline , plasma noradrenaline and plasma vasopressin in conscious rabbits . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
205,
215
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
225,
238
]
} |
all 3 manoeuvres resulted in elevation of blood pressure , heart rate and plasma noradrenaline and adrenaline concentrations . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
81,
94
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
99,
109
]
} |
we conclude that short-term , pharmacological doses of progesterone significantly reduce plasma concentrations of cholesterol , triglycerides , ldl cholesterol , and ldl apo b in men . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
114,
125
]
} | {
"id": "C0023824",
"name": "ldl cholesterol",
"pos": [
144,
159
]
} |
choledocholithiasis caused jaundice in only 7.1 % of the patients , reflecting the relatively low prevalence of gallstones in this population . | NA | {
"id": "C0701818",
"name": "choledocholithiasis",
"pos": [
0,
19
]
} | {
"id": "C0008350",
"name": "gallstones",
"pos": [
112,
122
]
} |
we recommend looking for pericardial effusion or pericarditis in patients with ibd and chest symptoms , and for ibd in obscure cases of these cardiac disorders . | NA | {
"id": "C0031039",
"name": "pericardial effusion",
"pos": [
25,
45
]
} | {
"id": "C0018799",
"name": "of",
"pos": [
133,
135
]
} |
in search of a practical biochemical test that will reflect hepatic steatosis , we assessed the significance of serum cholinesterase activity in 48 patients with nonalcoholic fatty liver , 16 obese subjects without fatty liver , 30 cases of chronic persistent hepatitis , 38 cases of chronic active hepatitis , and 20 ca... | NA | {
"id": "C0400966",
"name": "nonalcoholic fatty liver",
"pos": [
162,
186
]
} | {
"id": "C0015695",
"name": "fatty liver",
"pos": [
215,
226
]
} |
using this method we found a 1:3 likelihood of wound infection with a 5 % chance of severe infection when a single pathogenic species was cultured , and a 1:2 likelihood of wound infection with a 10 % chance of severe infection when two or more pathogenic species were cultured . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
53,
62
]
} | {
"id": "C0043241",
"name": "wound infection",
"pos": [
173,
188
]
} |
forty-one strains of adenovirus type 19/37 ( ad19/37 ) mainly isolated from patients with keratoconjunctivitis or conjunctivitis between 1974 and 1984 were re-evaluated by serum neutralization ( sn ) , haemagglutination inhibition ( hi ) and dna restriction analysis . | NA | {
"id": "C0022573",
"name": "keratoconjunctivitis",
"pos": [
90,
110
]
} | {
"id": "C0009763",
"name": "conjunctivitis",
"pos": [
114,
128
]
} |
however , by add-back experiments and the use of blocking antibodies , a monoclonal antibody against the il 2 receptor or antibodies against murine ifn-gamma , we demonstrated that ctl induction from mature thymocytes ( l3t4- , lyt-2+ ) requires cdf activity in addition to il 2 and ifn-gamma . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
73,
92
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
122,
132
]
} |
competitive radioimmunoassays performed with 125i-labeled monoclonal antibodies and purified antigen defined at least two distinct epitopes on sm-97 . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
93,
100
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
131,
139
]
} |
other investigators have shown that lipid x has some of the activities of lipid a in vitro and can inhibit the lethal toxicity of lps in vivo . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
74,
81
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
130,
133
]
} |
experiments were performed to assess the capacity of lectin ( con a ) , ionomycin , phorbol ester ( pma ) , and recombinant il 2 to mediate proliferation as well as the expression of cell surface il 2 receptors , two lymphokine genes , il 2 and ifn-gamma , and the c-myc proto-oncogene in cloned t cell populations . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
84,
97
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
100,
103
]
} |
the phorbol ester pma alone induced neither proliferation nor lymphokine gene expression but potentiated lectin and ionomycin-mediated signals . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
4,
17
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
18,
21
]
} |
in vitro phosphorylation studies with partially purified plasma membranes from resting b cells revealed that bsf1 interaction with membrane receptors stimulates a membrane-associated protein kinase that phosphorylates an endogenous protein of 44 kda . | NA | {
"id": "C0025252",
"name": "membrane",
"pos": [
64,
72
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
232,
239
]
} |
in view of the biphasic immune response after antigen presentation , the purpose of this study was to determine the presence of ica and antibodies against the 64,000 islet antigen after separation of igm from igg to prevent interference between the two antibody classes . | NA | {
"id": "C0003241",
"name": "ica",
"pos": [
128,
131
]
} | {
"id": "C0021017",
"name": "antibody",
"pos": [
253,
261
]
} |
a syngeneic monoclonal antibody to murine meth-a sarcoma ( hepss-1 ) recognizes heparan sulfate glycosaminoglycan ( hs-gag ) : cell density and transformation dependent alteration in cell surface hs-gag defined by hepss-1 . | NA | {
"id": "C0019143",
"name": "hs-gag",
"pos": [
116,
122
]
} | {
"id": "C0017973",
"name": "hs-gag",
"pos": [
196,
202
]
} |
the following evidence indicates that hepss-1 specifically recognizes an epitope present in heparan sulfate glycosaminoglycan ( hs-gag ) . | NA | {
"id": "C0019143",
"name": "hs-gag",
"pos": [
128,
134
]
} | {
"id": "C0017973",
"name": "hs-gag",
"pos": [
128,
134
]
} |
second , hs-gag but not seven other types of gag ( hyaluronic acid , heparin , chondroitin , chondroitin 4-sulfate , chondroitin 6-sulfate , dermatan sulfate , and keratan sulfate ) inhibited hepss-1 binding to meth-a cells . | NA | {
"id": "C0019143",
"name": "hs-gag",
"pos": [
9,
15
]
} | {
"id": "C0017973",
"name": "hs-gag",
"pos": [
9,
15
]
} |
second , hs-gag but not seven other types of gag ( hyaluronic acid , heparin , chondroitin , chondroitin 4-sulfate , chondroitin 6-sulfate , dermatan sulfate , and keratan sulfate ) inhibited hepss-1 binding to meth-a cells . | NA | {
"id": "C0017973",
"name": "hs-gag",
"pos": [
9,
15
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
69,
76
]
} |
second , hs-gag but not seven other types of gag ( hyaluronic acid , heparin , chondroitin , chondroitin 4-sulfate , chondroitin 6-sulfate , dermatan sulfate , and keratan sulfate ) inhibited hepss-1 binding to meth-a cells . | NA | {
"id": "C0017973",
"name": "hs-gag",
"pos": [
9,
15
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
117,
128
]
} |
second , hs-gag but not seven other types of gag ( hyaluronic acid , heparin , chondroitin , chondroitin 4-sulfate , chondroitin 6-sulfate , dermatan sulfate , and keratan sulfate ) inhibited hepss-1 binding to meth-a cells . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
79,
90
]
} | {
"id": "C0011602",
"name": "dermatan sulfate",
"pos": [
141,
157
]
} |
from the binding analysis of hepss-1 to various modified hs-gag and whale omega-heparin , it is additionally suggested that hepss-1 recognizes an epitope closely related to o-sulfated and n-acetylated glucosamine . | NA | {
"id": "C0019143",
"name": "hs-gag",
"pos": [
57,
63
]
} | {
"id": "C0017973",
"name": "hs-gag",
"pos": [
57,
63
]
} |
from the binding analysis of hepss-1 to various modified hs-gag and whale omega-heparin , it is additionally suggested that hepss-1 recognizes an epitope closely related to o-sulfated and n-acetylated glucosamine . | NA | {
"id": "C0017973",
"name": "hs-gag",
"pos": [
57,
63
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
80,
87
]
} |
thus hepss-1 is a first monoclonal antibody to hs-gag and seems to be useful to elucidate changes in cell surface hs-gag in normal cell growth and cell transformation . | NA | {
"id": "C0019143",
"name": "hs-gag",
"pos": [
47,
53
]
} | {
"id": "C0017973",
"name": "hs-gag",
"pos": [
114,
120
]
} |
we have previously reported that igm monoclonal antibodies ( mab ) that recognize surface carbohydrate determinants shared between schistosomula , cercariae , and miracidia block antibody/complement dependent killing of schistosomula in vitro . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
37,
58
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
179,
187
]
} |
our results suggest that ctl exhibiting the traditional fmr vs gcsa pattern of reactivity are directed against a tumor-associated antigen and not against virus-encoded antigens , and that ctl directed against mulv-encoded antigens demonstrate extensive cross-reactivity , including the ability to lyse akv-infected cells... | NA | {
"id": "C0003342",
"name": "virus",
"pos": [
154,
159
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
222,
230
]
} |
however , the following paper demonstrates that in immunoassays where antibodies or other proteins are bound directly to the nitrocellulose , 0.05 % tween 20 may dissociate these proteins from the membrane . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
90,
98
]
} | {
"id": "C0025252",
"name": "proteins",
"pos": [
179,
187
]
} |
in this new method lymphoblastoid cells are cultured in semisolid agarose in close physical association with human fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
34,
39
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
115,
126
]
} |
from these results it is concluded that the antiserum probably contains two populations of antibodies , one of which binds bivalently to the plates at all concentrations of immobilised hapten . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
44,
53
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
91,
101
]
} |
a rapid , sensitive immunoradiometric assay has been developed for human pregnancy-associated plasma protein a ( papp-a ) using a purified mouse monoclonal antibody as the tracer and a rabbit polyclonal antibody to this protein in the solid-phase antibody preparation . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
145,
155
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
247,
255
]
} |
they were then tested for the binding with tubular polypeptides fixed on a solid support , and the bound antibody representing anti-pre-s1 was detected by monoclonal antibody to human igm/mu or igg/gamma labeled with horseradish peroxidase . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
105,
113
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
155,
165
]
} |
in order to determine whether leu-3+8+ and/or leu-3+8- t cells are present in cell-mediated immune reactions in vivo , we studied the immunohistology of allergic contact dermatitis in 8 biopsies from 8 patients with positive patch tests and 3 biopsies from 2 patients with rhus dermatitis . | NA | {
"id": "C0162820",
"name": "allergic contact dermatitis",
"pos": [
153,
180
]
} | {
"id": "C0032342",
"name": "rhus",
"pos": [
273,
277
]
} |
the enzyme was assayed both in vivo and in vitro using a spin-labeled quaternary ammonium compound as the substrate , under saturating conditions in free radical substrate . | NA | {
"id": "C0037914",
"name": "spin-labeled",
"pos": [
57,
69
]
} | {
"id": "C0016693",
"name": "free radical",
"pos": [
149,
161
]
} |
sebaceous wax esters and epidermal acylceramides were isolated from skin surface lipid obtained from children and from young adults . | NA | {
"id": "C0043076",
"name": "wax",
"pos": [
10,
13
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
81,
86
]
} |
on the same subjects , 2 measures of sebum secretion rate were obtained , namely the sustainable wax ester secretion rate ( wesr ) on the forehead and the ratio of wax esters/ ( cholesterol + cholesterol esters ) [ we/ ( ch + ce ) ] in the surface lipid . | NA | {
"id": "C0043076",
"name": "wax",
"pos": [
97,
100
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
248,
253
]
} |
out of the following separated fractions : cholesterol , cholesterol ester , free fatty acid , glycolipids , and ceramide , 2 daily topical applications of ceramide fraction induced a significant and the highest increase in the conductance value as compared with ge/squalane base . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
43,
54
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
57,
74
]
} |
the elder brother 's radiograph on admission showed cardiomegaly with a cardiothoracic ratio of 60 % , and his electrocardiogram showed left ventricular hypertrophy and tall , peaked t waves in the precordial leads . | NA | {
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
52,
64
]
} | {
"id": "C0149721",
"name": "left ventricular hypertrophy",
"pos": [
136,
164
]
} |
the effects of postburn serum ( pbs ) on the production of colony-stimulating factor ( csf ) was evaluated in 13 burned patients by adding pbs to normal peripheral blood mononuclear cells ( mnc ) and assaying the mnc-conditioned media for csf content . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
153,
187
]
} | {
"id": "C0007634",
"name": "the mnc",
"pos": [
209,
216
]
} |
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