text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
aggregated c-reactive protein ( crp ) , an acute phase reactant , binds to and influences the functional activities of human mononuclear leukocytes . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
11,
29
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
43,
63
]
} |
we had previously demonstrated that c-reactive protein ( crp ) , an acute phase reactant , when aggregated or coupled to a ligand , interacts with monocytes and certain human peripheral blood lymphocytes . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
36,
54
]
} | {
"id": "C0001347",
"name": "acute phase",
"pos": [
68,
79
]
} |
binding of chemoattractants to their receptors on phagocytes activates a guanine nucleotide regulatory ( n ) protein through the substitution of gtp for gdp on n . | NA | {
"id": "C0018328",
"name": "guanine",
"pos": [
73,
80
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
145,
148
]
} |
binding of chemoattractants to their receptors on phagocytes activates a guanine nucleotide regulatory ( n ) protein through the substitution of gtp for gdp on n . | NA | {
"id": "C0018328",
"name": "guanine",
"pos": [
73,
80
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
153,
156
]
} |
the metabolism of apolipoprotein b was examined in four lipoprotein subclasses of sf 60-400 ( large very low density lipoprotein ( vldl ) ) , sf 20-60 ( small vldl ) , sf 12-20 ( intermediate density lipoprotein ( idl ) ) , and sf 0-12 ( low density lipoprotein ( ldl ) ) before and during bezafibrate therapy . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
21,
32
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
159,
163
]
} |
the metabolism of apolipoprotein b was examined in four lipoprotein subclasses of sf 60-400 ( large very low density lipoprotein ( vldl ) ) , sf 20-60 ( small vldl ) , sf 12-20 ( intermediate density lipoprotein ( idl ) ) , and sf 0-12 ( low density lipoprotein ( ldl ) ) before and during bezafibrate therapy . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
21,
32
]
} | {
"id": "C0065063",
"name": "intermediate density lipoprotein",
"pos": [
179,
211
]
} |
the choline-linked fraction contained high arachidonic acid contents in 1-o-alkyl-2-acyl- ( 18 % ) and 1,2-diacyl-sn-glycero-3-phosphocholine ( 11 % ) , with smaller amounts in 1-o-alk-1'-enyl-2-acyl species , whereas the arachidonic acid content of the ethanolamine-linked fraction was high in 1-o-alk-1'-enyl-2-acyl ( ... | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
4,
11
]
} | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
127,
141
]
} |
we have called them type c cells ( containing cells with some of the properties of osteoclasts ) and type b cells ( containing osteoblast-like cells , as well as fibroblasts , chondrocytes and other stromal cells ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
27,
32
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
162,
173
]
} |
we have called them type c cells ( containing cells with some of the properties of osteoclasts ) and type b cells ( containing osteoblast-like cells , as well as fibroblasts , chondrocytes and other stromal cells ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
27,
32
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
176,
188
]
} |
this effect could be mimicked if fibroblasts replaced b cells and cell contact was essential for this response . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
33,
44
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
66,
70
]
} |
the serum lipoproteins were fractionated by density gradient ultracentrifugation into very low density lipoproteins ( vldl ) , low density lipoproteins ( ldl ) , and into the high density lipoprotein ( hdl ) subfractions 2 and 3 ( hdl2 , hdl3 ) . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
10,
22
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
86,
115
]
} |
various inhibitors of phenylethanolamine n-methyltransferase ( pnmt ) , the enzyme which catalyses the conversion of noradrenaline to adrenaline , were administered to freely moving ovariectomized rats bearing an atrial cannula . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
117,
130
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
134,
144
]
} |
the effect of these drugs on the level of dopamine , noradrenaline and adrenaline in the hypothalamus ( including preoptic area ) was assessed . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
53,
66
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
71,
81
]
} |
using the ed50 and the first three stimuli as control , the effects of morphine ( 10 nmol/l-l mmol/l ) , d-ala2-mephe4-met-enkephalin- ( o5 ) -ol ( damme ; 10 nmol/l-0.1 mmol/l ) and naloxone ( 10 nmol/l-10 mumol/l ) on the response to the next three stimuli were compared . | NA | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
119,
133
]
} | {
"id": "C0949300",
"name": "damme",
"pos": [
148,
153
]
} |
in normal rats , administration of proteases did not have significant effects on urinary protein excretion , serum creatinine , or renal morphology , nor did protease affect anti-rabbit igg antibody production in rats injected with heymann antibody . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
35,
44
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
158,
166
]
} |
serum amyloid a ( saa ) is a major acute-phase reactant and apoprotein of high density lipoprotein ( hdl ) . | NA | {
"id": "C0002723",
"name": "serum amyloid a",
"pos": [
0,
15
]
} | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
35,
55
]
} |
the peptide portion of the antigen was an alanine and proline-rich molecule that lacked aromatic and sulfur-containing amino acids . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
42,
49
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
119,
130
]
} |
to gain insight into the process of lymphomagenesis in aids and to investigate a possible pathogenetic relationship between las and nhl , we investigated the clonality of the b or t lymphoid populations by ig or t beta gene rearrangement analysis , the presence of rearrangements involving the c-myc oncogene locus , and... | NA | {
"id": "C0024305",
"name": "nhl",
"pos": [
132,
135
]
} | {
"id": "C0079731",
"name": "b-nhl",
"pos": [
400,
405
]
} |
our data indicate that multiple clonal b cell expansions are present in a significant percentage of las ( approximately 20 % ) and b-nhl ( 60 % ) biopsies . c-myc rearrangements/translocations are detectable in 9 of our 10 nhls , but not in any of the las cases . | NA | {
"id": "C0079731",
"name": "b-nhl",
"pos": [
131,
136
]
} | {
"id": "C0024305",
"name": "nhls",
"pos": [
223,
227
]
} |
the antigenic epitopes shared by human complement proteins and mouse lymphocyte pfp are limited to cysteine-rich domains . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
4,
13
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
14,
22
]
} |
in this study , we show that etaf and il-1 are identical by the following criteria : both normal and malignant human keratinocytes contain mrnas identical to monocytic il-1 alpha and il-1 beta mrna , as determined by an s1 nuclease protection assay ; | NA | {
"id": "C0021755",
"name": "il-1",
"pos": [
38,
42
]
} | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
168,
178
]
} |
while human monocytes produce a large excess of il-1 beta after appropriate stimulation , these data suggest that il-1 alpha is a major ( and may be the predominant ) form of il-1 produced by human keratinocytes . | NA | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
114,
124
]
} | {
"id": "C0021755",
"name": "il-1",
"pos": [
175,
179
]
} |
they were mapped on the viral genome by northern blot hybridization to subgenomic probes , by cdna hybridization to viral dna fragments and by s1 analysis of unlabelled and 3 ' and 5 ' end-labelled dna fragments . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
116,
125
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
198,
201
]
} |
nucleocapsid protein and phosphoprotein were found in every diseased brain area , whereas haemagglutinin ( h ) protein was detected in two , fusion ( f ) protein in three and m protein only in one sspe case . | NA | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
25,
39
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
177,
184
]
} |
the results may indicate the existence of a presynaptic npy receptor on the noradrenaline and/or adrenaline nerve terminals , which may enhance the presynaptic alpha 2-adrenoreceptor function to inhibit 3h-na release . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
79,
89
]
} | {
"id": "C0028351",
"name": "na",
"pos": [
206,
208
]
} |
central dopaminergic ( da ) function in children and adults was assessed by monitoring plasma-free levels of the dopamine metabolite homovanillic acid ( phva ) before and after a single oral dose and chronic oral administration of debrisoquin . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
8,
20
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
113,
121
]
} |
we have indeed defined d1 and d2 receptors those da receptors associated or unassociated to the generation of cyclic amp , respectively . | NA | {
"id": "C0058698",
"name": "d2 receptors",
"pos": [
30,
42
]
} | {
"id": "C0034798",
"name": "da receptors",
"pos": [
49,
61
]
} |
thirteen subjects with essential hypertension controlled on oral enalapril ( 20 mg/day ) therapy were entered into a protocol to assess serially 24-hour blood pressure , the renin-angiotensin-aldosterone system , angiotensin-converting enzyme activity , and plasma and urine enalaprilat drug levels , following both chro... | NA | {
"id": "C0014025",
"name": "enalapril",
"pos": [
65,
74
]
} | {
"id": "C0014027",
"name": "enalaprilat",
"pos": [
394,
405
]
} |
results indicate that systolic and diastolic blood pressures remain well controlled following cessation of oral enalapril and replacement with intravenous enalaprilat . | NA | {
"id": "C0014025",
"name": "enalapril",
"pos": [
112,
121
]
} | {
"id": "C0014027",
"name": "enalaprilat",
"pos": [
155,
166
]
} |
enalaprilat drug levels , following oral enalapril and intravenous enalaprilat , remained above the therapeutic levels required for angiotensin-converting enzyme inhibition . | NA | {
"id": "C0014025",
"name": "enalapril",
"pos": [
0,
9
]
} | {
"id": "C0014027",
"name": "enalaprilat",
"pos": [
67,
78
]
} |
however , therapeutic enalaprilat levels can probably be achieved with one fourth of the total cumulative dose of enalapril , administered as enalaprilat at 6-hour intervals . | NA | {
"id": "C0014025",
"name": "enalapril",
"pos": [
22,
31
]
} | {
"id": "C0014027",
"name": "enalaprilat",
"pos": [
142,
153
]
} |
however , immunoreactive plasma angiotensin ii concentrations were not suppressed below pretreatment values , suggesting that chronic enalapril/acute enalaprilat therapy controls blood pressure through a nonangiotensin-mediated antihypertension mechanism . | NA | {
"id": "C0014025",
"name": "enalapril",
"pos": [
134,
143
]
} | {
"id": "C0014027",
"name": "enalaprilat",
"pos": [
150,
161
]
} |
the cost of monitoring is high , not only in financial terms , but also in terms of the time devoted to machines , electrodes , and sensors , and in terms of complications such as shearing , infections , vasospasm , hematomas , and even fatal hemorrhage . | NA | {
"id": "C0018944",
"name": "hematomas",
"pos": [
216,
225
]
} | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
243,
253
]
} |
clones of tumor chondrocytes were established in agarose and were examined over 2-3 weeks for evidence that the cells were accumulating a proteoglycan-rich extracellular matrix , as determined by positive staining by alcian blue , and were undergoing cell division . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
16,
28
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
112,
117
]
} |
these results suggest that the chondrocytes from the rat chondrosarcoma form a homogeneous cell population with respect to their ability to synthesize an extra-cellular matrix and divide . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
31,
43
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
160,
164
]
} |
graft necrosis followed by cellular proliferation suggested that a different population of cells other than the native pt fibroblasts may be inhabiting the graft . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
91,
96
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
122,
133
]
} |
one pattern showed intact basal lamina with associated periductal stromal cells consisting entirely of fibroblasts , the other pattern showed disruption of basal lamina by gaps and malignant cell protrusions with associated stromal cells consisting of both fibroblasts and myofibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
74,
78
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
276,
287
]
} |
we investigated the pathophysiology underlying defective bone mineralization in two individuals and examined the effects of 1,25-dihydroxyvitamin d ( 1,25 ( oh ) 2d , calcitriol ) therapy on the clinical and biochemical abnormalities . | NA | {
"id": "C0012328",
"name": "dihydroxyvitamin d",
"pos": [
129,
147
]
} | {
"id": "C0006674",
"name": "calcitriol",
"pos": [
167,
177
]
} |
the strong red fluorescence of the cysticercus of taenia solium depends on the presence of several porphyrins in the vesicular fluid of the parasite : probably protoporphyrin ix , coproporphyin i or iii , and 2 decarboxylated porphyrins intermediate between uroporphyrin and coproporphyrin . | NA | {
"id": "C0033733",
"name": "protoporphyrin ix",
"pos": [
160,
177
]
} | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
226,
236
]
} |
the strong red fluorescence of the cysticercus of taenia solium depends on the presence of several porphyrins in the vesicular fluid of the parasite : probably protoporphyrin ix , coproporphyin i or iii , and 2 decarboxylated porphyrins intermediate between uroporphyrin and coproporphyrin . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
99,
109
]
} | {
"id": "C0042093",
"name": "uroporphyrin",
"pos": [
258,
270
]
} |
the strong red fluorescence of the cysticercus of taenia solium depends on the presence of several porphyrins in the vesicular fluid of the parasite : probably protoporphyrin ix , coproporphyin i or iii , and 2 decarboxylated porphyrins intermediate between uroporphyrin and coproporphyrin . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
99,
109
]
} | {
"id": "C0009988",
"name": "coproporphyrin",
"pos": [
275,
289
]
} |
these findings suggest either that septum formation and branch initiation proceed independently of synthesis of new proteins or that proteins related to these processes are synthesized too transiently or in amounts too small to be detected under the conditions of the experiments . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
99,
108
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
133,
141
]
} |
this was reported several years ago , and has continued to be a consistent finding , prompting us to attempt hydrostatic barium enema reductions of recurrent intussusceptions in infants and children and also in older children with a first intussusception . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
190,
198
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
211,
225
]
} |
hypoxanthine and the catecholamines , dopamine , norepinephrine and epinephrine were determined in umbilical venous cord plasma in 27 term babies delivered vaginally . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
49,
63
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
68,
79
]
} |
in these babies norepinephrine ( 3710 +/- 3888 vs 789 +/- 718 pg/ml , p less than 0.01 ) and epinephrine ( 298 +/- 229 vs 148 +/- 116 pg/ml , p less than 0.05 ) were significantly elevated as well , in contrast to dopamine levels ( 188 +/- 94 vs 169 +/- 134 pg/ml n. s. ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
16,
30
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
93,
104
]
} |
however , enhanced tdr3h incorporation in treated cells was not correlated with an overall increase of the fibroblast population compared with control cultures as evidenced by cell counts and microscopic examination . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
50,
55
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
107,
117
]
} |
thirty-two patients had no sodium hyaluronate ( healon ) and 36 patients had healon injected into the anterior chamber prior to the laser surgery . | NA | {
"id": "C0087000",
"name": "sodium hyaluronate",
"pos": [
27,
45
]
} | {
"id": "C0020196",
"name": "healon",
"pos": [
77,
83
]
} |
the population and first-encounter patient distributions were equivalent except for gender : relatively more males than females received service . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
84,
90
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
122,
127
]
} |
when this compound was treated with secondary amines , good yields of mannich bases could be isolated . | NA | {
"id": "C0002508",
"name": "amines",
"pos": [
46,
52
]
} | {
"id": "C0024728",
"name": "mannich bases",
"pos": [
70,
83
]
} |
the synthesis of a series of n-1,4-disubstituted-1,4-dihydro-5h-tetrazol-5-one piperidinyl derivatives of fentanyl , carfentanil , and sufentanil is described . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
106,
114
]
} | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
135,
145
]
} |
synthesis and renal vasodilator activity of some dopamine agonist 1-aryl-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diols : halogen and methyl analogues of fenoldopam . | NA | {
"id": "C0005034",
"name": "benzazepine",
"pos": [
97,
108
]
} | {
"id": "C0060180",
"name": "fenoldopam",
"pos": [
153,
163
]
} |
latent chiral characters of nifedipine derivatives with the identical ester groups were assigned by comparison of their puckering modes of 1,4-dihydropyridine ( dhp ) rings with those found in 3a x hcl or 3a x hbr . | NA | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
28,
38
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
143,
158
]
} |
identification of the anion exchange protein of ehrlich cells : a kinetic analysis of the inhibitory effects of 4,4'-diisothiocyano-2,2'-stilbene-disulfonic acid ( dids ) and labeling of membrane proteins with 3h-dids . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
37,
44
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
187,
204
]
} |
ion substitution experiments showed that the rectified current was carried mostly by cations moving from cell to mucosa . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
0,
3
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
85,
92
]
} |
both the rate of synthesis and the accumulation of rna directed by t7 rna polymerase can reach levels comparable with those for ribosomal rnas in a normal cell . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
51,
54
]
} | {
"id": "C0035701",
"name": "ribosomal rnas",
"pos": [
128,
142
]
} |
the hybrid genes have been inserted into a p-element transformation vector and the constructs introduced into cultured drosophila kc cells by calcium phosphate-mediated transfection , or into the germ-lines of flies by p-element-mediated transformation . | NA | {
"id": "C0013879",
"name": "element",
"pos": [
45,
52
]
} | {
"id": "C0031705",
"name": "p-element",
"pos": [
219,
228
]
} |
this suggests that hypersensitivity of dna in chromatin reflects a greater accessibility of the dna rather than its altered conformation . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
39,
42
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
131,
132
]
} |
a new membrane-associated dna replication protein , the gene 69 product of bacteriophage t4 , shares a patch of homology with the escherichia coli dnaa protein . | NA | {
"id": "C0025252",
"name": "membrane",
"pos": [
6,
14
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
152,
159
]
} |
published experimental data on topoisomer distributions in circular dna molecules are interpreted to estimate the torsional rigidity of dna in solution . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
59,
71
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
136,
139
]
} |
the relaxed nucleoprotein is gradually supercoiled into nucleosomal chromatin in the s-150 , via a pathway that requires atp and is blocked by novobiocin , and this process is accompanied by the appearance of mature histones h3 and h4 . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
12,
25
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
68,
77
]
} |
diethylpyrocarbonate ( depc ) carbethoxylates z-dna to an increased extent because the reactive n-7 atoms of purine residues appear structurally more accessible on z-dna as opposed to b-dna . | NA | {
"id": "C0043442",
"name": "z-dna",
"pos": [
46,
51
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
186,
189
]
} |
the ribonucleoprotein organization of snrnps is summarized and discussed in view of our current knowledge on snrna sequences protected by proteins . | NA | {
"id": "C0035544",
"name": "ribonucleoprotein",
"pos": [
4,
21
]
} | {
"id": "C0142661",
"name": "snrnps",
"pos": [
38,
44
]
} |
one of the globular domains is assigned to the light chain ( b-chain ) of the activated molecule , which is homologous to trypsin and other serine proteases . | NA | {
"id": "C0041236",
"name": "trypsin",
"pos": [
122,
129
]
} | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
140,
156
]
} |
we propose that nucleotide selection during ongoing dna synthesis results largely from the different relative rates of forward ( beta ) and backward ( -alpha ) reactions involving the [ dnan x dnmp x ppi ] intermediate : the forward ( incorporation ) reaction is expected to predominate for the correct nucleotide , wher... | NA | {
"id": "C0011529",
"name": "dnmp",
"pos": [
193,
197
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
400,
411
]
} |
equal amounts of aminoacyl-trna isoacceptors with contrasting isotopes were added in pairs to reticulocyte lysates and allowed to incorporate their amino acids into rabbit globin . | NA | {
"id": "C0035714",
"name": "aminoacyl-trna",
"pos": [
17,
31
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
148,
159
]
} |
there is little evidence that adjacent bases or codons in messenger rna affect the trnas preferred in the translation of most sites . | NA | {
"id": "C0009221",
"name": "codons",
"pos": [
48,
54
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
58,
71
]
} |
preparative hybridization of x. laevis 18 s ribosomal rna restriction fragments of ribosomal dna , followed by fingerprinting analysis on rna recovered from the hybrids , allowed each methylated oligonucleotide to be mapped to a specific region within 18 s ribosomal rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
54,
57
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
257,
270
]
} |
the locations of most of the methyl groups in human 18 s ribosomal rna were deduced from the high degree of correspondence between methylated oligonucleotides from human and x. laevis 18 s rna , together with knowledge of the human 18 s ribosomal dna sequence . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
57,
70
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
189,
192
]
} |
the computed epitopes occur in homologous positions in all the immunoglobulin domains , and most of the beta-sheet surfaces on the domains are poorly antigenic . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
13,
21
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
150,
159
]
} |
variable domain epitopes ( idiotypes ) involve both hypervariable and framework residues , and only about 25 % of the hypervariable residues are strongly antigenic . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
16,
24
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
154,
163
]
} |
the increase in diphosphoglycerate binding by this hemoglobin was in good agreement with that expected from the dimer-tetramer dissociation constant over a wide range of hemoglobin concentrations . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
51,
61
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
189,
190
]
} |
using a closed chest embolization procedure , autoradiographic ( 141-cerium at onset of ischemia ) microsphere risk zone analysis and tetrazolium staining , the ability of nifedipine to influence collateral flow , energy metabolism and infarct size over 48 h was assessed in the dog . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
88,
96
]
} | {
"id": "C0021308",
"name": "infarct",
"pos": [
236,
243
]
} |
the results indicate : nifedipine may still afford some small degree of protection up to 48 h of elapsed ischemia , ( infarct size as a percent of risk zone size was 86.1 +/- 3.0 in control vs 70.4 +/- 4.5 in drug group ( p less than 0.025 n = 9 in each group ) , 'salvage ' in both the control and the nifedipine-treate... | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
105,
113
]
} | {
"id": "C0021308",
"name": "infarct",
"pos": [
118,
125
]
} |
residue levels of the chlorinated hydrocarbons p , p'-ddt ( 2,2-bis ( p-chlorophenyl ) -1,1,1-trichloroethane ) , p , p'-dde ( 2,2-bis ( p-chlorophenyl ) -1,1-dichloroethane ) , hexachlorobenzene ( hcb ) , alpha- , beta- , and gamma-hexachlorocyclohexane ( hch ) , aldrin , dieldrin , and polychlorinated biphenyls ( pcb... | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
22,
46
]
} | {
"id": "C0040904",
"name": "trichloroethane",
"pos": [
94,
109
]
} |
residue levels of the chlorinated hydrocarbons p , p'-ddt ( 2,2-bis ( p-chlorophenyl ) -1,1,1-trichloroethane ) , p , p'-dde ( 2,2-bis ( p-chlorophenyl ) -1,1-dichloroethane ) , hexachlorobenzene ( hcb ) , alpha- , beta- , and gamma-hexachlorocyclohexane ( hch ) , aldrin , dieldrin , and polychlorinated biphenyls ( pcb... | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
22,
46
]
} | {
"id": "C0011038",
"name": "p , p",
"pos": [
47,
52
]
} |
residue levels of the chlorinated hydrocarbons p , p'-ddt ( 2,2-bis ( p-chlorophenyl ) -1,1,1-trichloroethane ) , p , p'-dde ( 2,2-bis ( p-chlorophenyl ) -1,1-dichloroethane ) , hexachlorobenzene ( hcb ) , alpha- , beta- , and gamma-hexachlorocyclohexane ( hch ) , aldrin , dieldrin , and polychlorinated biphenyls ( pcb... | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
22,
46
]
} | {
"id": "C0005038",
"name": "gamma-hexachlorocyclohexane",
"pos": [
227,
254
]
} |
residue levels of the chlorinated hydrocarbons p , p'-ddt ( 2,2-bis ( p-chlorophenyl ) -1,1,1-trichloroethane ) , p , p'-dde ( 2,2-bis ( p-chlorophenyl ) -1,1-dichloroethane ) , hexachlorobenzene ( hcb ) , alpha- , beta- , and gamma-hexachlorocyclohexane ( hch ) , aldrin , dieldrin , and polychlorinated biphenyls ( pcb... | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
22,
46
]
} | {
"id": "C0002011",
"name": "aldrin",
"pos": [
265,
271
]
} |
residue levels of the chlorinated hydrocarbons p , p'-ddt ( 2,2-bis ( p-chlorophenyl ) -1,1,1-trichloroethane ) , p , p'-dde ( 2,2-bis ( p-chlorophenyl ) -1,1-dichloroethane ) , hexachlorobenzene ( hcb ) , alpha- , beta- , and gamma-hexachlorocyclohexane ( hch ) , aldrin , dieldrin , and polychlorinated biphenyls ( pcb... | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
22,
46
]
} | {
"id": "C0012141",
"name": "dieldrin",
"pos": [
274,
282
]
} |
incubation of the parasites in the presence of neuraminidase from clostridium perfringens or vibrio cholerae or in the presence of proteolytic enzymes ( trypsin or protease ) did not interfere with the surface charge . | NA | {
"id": "C0030940",
"name": "proteolytic enzymes",
"pos": [
131,
150
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
164,
172
]
} |
the proteins derived from these plasmids indicated that the linear gene order for viral proteins encoded in segment a is beta , gamma 2 , and gamma 1 . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
4,
12
]
} | {
"id": "C0042736",
"name": "gene",
"pos": [
67,
71
]
} |
one of the latter monoclonal antibodies also immunoprecipitated large t but not small t of simian virus 40 , suggesting that the site recognized by this antibody may be functionally important . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
18,
39
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
153,
161
]
} |
the sequences spanning the junction between the termini present in concatemeric dna was also determined and compared with that expected when the two ends of the mature dna were juxtaposed . | NA | {
"id": "C1257941",
"name": "concatemeric dna",
"pos": [
67,
83
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
168,
171
]
} |
large proportions of the mutant src proteins exist in soluble complexes with cellular proteins p50 and p90 , even though the src proteins are myristylated . | NA | {
"id": "C1564139",
"name": "mutant",
"pos": [
25,
31
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
129,
137
]
} |
amoxicillin ( 51.4 reactions per 1000 patients exposed ) , trimethoprim-sulfamethoxazole ( 33.8/1000 ) , and ampicillin ( 33.2/1000 ) had the highest reaction rates . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
0,
11
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
109,
119
]
} |
there was no significant difference in the frequency of fcd , bda , and apocrine metaplasia between the cases of liver cirrhosis and those without any hepatic disorders ( controls ) . | NA | {
"id": "C0023890",
"name": "of liver cirrhosis",
"pos": [
110,
128
]
} | {
"id": "C0023895",
"name": "hepatic",
"pos": [
151,
158
]
} |
[ nursing of patients with difficulties in deglutition . assistance at independent oral feeding by a patient with difficulty in swallowing due to esophageal disease -- nursing of an aged patient following surgery of esophageal cancer ] . | NA | {
"id": "C0011168",
"name": "difficulty in swallowing",
"pos": [
114,
138
]
} | {
"id": "C0014852",
"name": "esophageal",
"pos": [
216,
226
]
} |
the pulmonary hyperventilation ( hv ) test was carried out in 31 coronary patients with stable angina and 11 patients with spontaneous ( angiospastic ) angina . | NA | {
"id": "C0340288",
"name": "stable angina",
"pos": [
88,
101
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
152,
158
]
} |
coli lipopolysaccharide endotoxin ( lps ) to adult male munich-wistar rats ( n = 18 ) resulted in a progressive fall in rbf and gfr from 6.9 +/- 0.2 se and 1.1 +/- 0.05 ml/min to minimal values at 50 minutes of 3.8 +/- 0.4 and 0.32 +/- 0.08 ( p less than 0.05 ) , respectively , without a fall in mean arterial pressure ... | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
24,
33
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
36,
39
]
} |
infusion of saralasin , an angiotensin ii ( aii ) antagonist , largely normalized these indices , including urinary protein excretion ( to approximately 35 mg/24 hrs per kidney ) , despite continued rvc . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
12,
21
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
27,
41
]
} |
the binding of huplt cp to gcw appears to be ionic in nature since heparin , a polyanion , prevents this binding in vitro . | NA | {
"id": "C0007447",
"name": "huplt cp",
"pos": [
15,
23
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
45,
50
]
} |
in experiments of in vitro binding of purified huplt cp to section of normal kidney treatment with heparin completely restores the normal pattern of colloidal iron staining suggesting ionic neutralization of gpa . | NA | {
"id": "C0007447",
"name": "huplt cp",
"pos": [
47,
55
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
184,
189
]
} |
these observations indicate that under these conditions the ionic interaction of huplt cp with gcw is only partially responsible for the loss of colloidal iron staining . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
60,
65
]
} | {
"id": "C0007447",
"name": "huplt cp",
"pos": [
81,
89
]
} |
the metabolism of catecholamines ( ca ) in non-selected patients with chronic renal failure and under hemodialysis ( crfh ) was studied by measuring the concentration of plasma free , sulfo- and glucuroconjugated ca , dopamine ( da ) , norepinephrine ( ne ) , and epinephrine ( epi ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
236,
250
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
264,
275
]
} |
our data demonstrate a statistically significant increase of free da and free ne concentration in crfh , while that of free epi was not different from controls . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
78,
80
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
124,
127
]
} |
suspecting that conjugated ca might be altered in crfh , plasma sulfo- and glucuro-conjugated da , ne and epi were also measured . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
99,
101
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
106,
109
]
} |
plasma concentration of glucuro-conjugated da and ne in crfh was not different from controls , while that of glucuro-conjugated epi was significantly increased . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
50,
52
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
128,
131
]
} |
on the basis of the test results it seems justified to aim for a minimal refractive error in the pseudophakic eye of about +/- 0.5 d in patients with hypermetropia or myopia up to 4 d , even if subjective aniseikonias of over 10 % can be proved . | NA | {
"id": "C0034951",
"name": "refractive",
"pos": [
73,
83
]
} | {
"id": "C0020490",
"name": "hypermetropia",
"pos": [
150,
163
]
} |
on the basis of the test results it seems justified to aim for a minimal refractive error in the pseudophakic eye of about +/- 0.5 d in patients with hypermetropia or myopia up to 4 d , even if subjective aniseikonias of over 10 % can be proved . | NA | {
"id": "C0034951",
"name": "refractive",
"pos": [
73,
83
]
} | {
"id": "C0027092",
"name": "myopia",
"pos": [
167,
173
]
} |
on the basis of the test results it seems justified to aim for a minimal refractive error in the pseudophakic eye of about +/- 0.5 d in patients with hypermetropia or myopia up to 4 d , even if subjective aniseikonias of over 10 % can be proved . | NA | {
"id": "C0034951",
"name": "refractive",
"pos": [
73,
83
]
} | {
"id": "C0003078",
"name": "aniseikonias",
"pos": [
205,
217
]
} |
nevertheless typical signs as capillary lengthening , capillary branching ( 53 % ) and haemorrhagic margin ( 75 % ) are of considerable differential-diagnostic value when it comes to distinguishing a case of thrombangiitis obliterans from a case of degenerative arterial occlusive disease . | NA | {
"id": "C0040021",
"name": "thrombangiitis obliterans",
"pos": [
208,
233
]
} | {
"id": "C0003838",
"name": "arterial occlusive",
"pos": [
262,
280
]
} |
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