text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
at different stages of bed rest and recovery the content of lipoprotein fractions and lipids of different classes in serum was measured by thin-layer chromatography . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
60,
71
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
86,
92
]
} |
multiple chromosome abnormalities are found in this cell line , some in the same area of the genome in which abnormalities were found in other human hepatomas . | NA | {
"id": "C0000772",
"name": "multiple",
"pos": [
0,
8
]
} | {
"id": "C0000768",
"name": "abnormalities",
"pos": [
109,
122
]
} |
the albumin-injected rats developed slight but significant increases in blood pressure , serum albumin , plasma volume , and urine urea nitrogen compared to the saline injected controls . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
4,
11
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
89,
102
]
} |
effects of phenylbutazone and oxyphenbutazone on acidic drug detection in high performance thin layer chromatographic systems . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
11,
25
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
30,
45
]
} |
we investigated the ability of phenylbutazone and oxyphenbutazone to mask or interfere with the detection of acidic drugs of high performance thin layer chromatography . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
31,
45
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
50,
65
]
} |
three medications ( diclofenac , fenoprofen , ibuprofen ) were potentially masked by phenylbutazone and one ( sulindac ) was potentially masked by oxyphenbutazone . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
85,
99
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
147,
162
]
} |
in each case , metabolites of these agents were detectable for at least 24 hr after drug administration and detection was not interfered with by phenylbutazone or oxyphenbutazone . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
145,
159
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
163,
178
]
} |
here i present evidence to show that pd may result from a primary loss of active tachykinin , probably substance p ( sp ) in the substantia nigra ( sn ) , and that this loss leads to a secondary degeneration of the dopaminergic neurones . | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
81,
91
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
103,
114
]
} |
between 1975 and 1986 , aspirin or aspirin with dipyridamole has been used for anticoagulation in children receiving a mechanical aortic valve at the university of california , san francisco . | NA | {
"id": "C0004057",
"name": "aspirin",
"pos": [
24,
31
]
} | {
"id": "C0732279",
"name": "aspirin",
"pos": [
35,
42
]
} |
fifty-one patients ( ages 1 to 23 years , mean 12.9 years ) were treated with aspirin ( n = 45 ) or aspirin with dipyridamole ( n = 6 ) and observed a mean of 36.5 months ( range 3 to 100 months ) . | NA | {
"id": "C0004057",
"name": "aspirin",
"pos": [
78,
85
]
} | {
"id": "C0732279",
"name": "aspirin",
"pos": [
100,
107
]
} |
these results show that children with mechanical aortic valves in normal sinus rhythm can be safely treated with aspirin ( or aspirin with dipyridamole ) with little risk of thromboembolic events , valve thrombosis , or valve failure . | NA | {
"id": "C0004057",
"name": "aspirin",
"pos": [
113,
120
]
} | {
"id": "C0732279",
"name": "aspirin",
"pos": [
126,
133
]
} |
as such it promises to be very useful to discriminate amongst the wide range of antibodies to various kinds of materials produced by hybridomas by detecting monoclonal antibodies directed against factors contained in well-defined tissues in which one is interested . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
80,
90
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
157,
167
]
} |
the tracers are , horseradish peroxidase ( hrp ) , wheat germ agglutinin ( wga ) , cholera toxin subunit b ( ctb ) , wheat germ agglutinin-horseradish peroxidase conjugate ( wga-hrp ) , cholera toxin subunit b-horseradish peroxidase conjugate ( ctb-hrp ) , fast blue ( fb ) , diamidino yellow ( dy ) , and rhodamine micr... | NA | {
"id": "C0078473",
"name": "wheat germ agglutinin-horseradish peroxidase conjugate",
"pos": [
117,
171
]
} | {
"id": "C0019941",
"name": "hrp",
"pos": [
249,
252
]
} |
these subjects were then given an infusion of prostacyclin , in the form of epoprostenol sodium salt ( dialysis ii : prostacyclin , 5 ng x kg-1 x min-1 ) , followed by an infusion of prostacyclin and heparin ( dialysis iii : heparin regimen 2,500 u/h ) . | NA | {
"id": "C0354594",
"name": "epoprostenol sodium",
"pos": [
76,
95
]
} | {
"id": "C0033567",
"name": "prostacyclin",
"pos": [
183,
195
]
} |
norepinephrine and epinephrine inhibited the capacity of gamma interferon and lipopolysaccharide to stimulate il-1 production from mouse peritoneal macrophages . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
19,
30
]
} |
this , coupled with the capacity of norepinephrine and epinephrine to enhance intracellular camp levels in macrophages , strongly suggested that the catecholamine-induced suppression of il-1 production may be mediated by elevated intracellular camp levels . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
36,
50
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
55,
66
]
} |
human t cell hybridomas producing cytotoxic lymphokines : induction of lymphotoxin release and killer cell activity by anti-cd3 monoclonal antibody or lectins and phorbol ester . | NA | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
44,
55
]
} | {
"id": "C0024320",
"name": "lymphotoxin",
"pos": [
71,
82
]
} |
the phorbol ester , phorbol 12-myristate 13-acetate ( pma ) in combination with phytohemagglutinin or concanavalin a , were required for maximal release of lt and il-2 . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
4,
17
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
20,
27
]
} |
this human t cell hybrid line offers an inducible model system for the simultaneous study of the molecular events regulating the production of growth inhibitory/cytotoxic ( lt ) and growth promoting ( il-2 ) lymphokines and cytotoxic t cell function . | NA | {
"id": "C0024320",
"name": "lt",
"pos": [
75,
77
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
208,
219
]
} |
the engulfment of yeast cells was depressed by colchicine ( p = 0.031 ) but not by the lumicolchicines . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
47,
57
]
} | {
"id": "C0024096",
"name": "lumicolchicines",
"pos": [
87,
102
]
} |
this syndrome also includes elements of premature ageing ( i.e. , a markedly shortened lifespan and premature occurrence of diseases associated with ageing ) . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
5,
13
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
124,
132
]
} |
when human diploid fibroblasts , tig-1 , reached the end of their proliferative lifespan in vitro , they still could synthesize proteins with molecular weight of about 70,000 , 85,000 and 116,000 following the heat shock at 46 degrees c for 10 min as well as young cells did so . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
19,
30
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
265,
270
]
} |
these results raise the further possibility that the aca , or related antiphospholipid antibodies , may play a part in progressive coronary vessel disease . | NA | {
"id": "C0162596",
"name": "aca",
"pos": [
53,
56
]
} | {
"id": "C0162595",
"name": "antiphospholipid antibodies",
"pos": [
70,
97
]
} |
it can also be caused by other forms of trauma , including blunt trauma , but rarely does it occur without trauma . | NA | {
"id": "C0043253",
"name": "blunt trauma",
"pos": [
59,
71
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
107,
113
]
} |
membrane phospholipids were labelled with [ 3h ] inositol and their conversion to [ 3h ] labelled inositol phosphate was measured in the presence of li+ ( 10 mm ) . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
49,
57
]
} | {
"id": "C0021554",
"name": "inositol",
"pos": [
98,
106
]
} |
however , the adenosine analogues , l-n6-phenylisopropyladenosine and 5 ' n-ethylcarboxamidoadenosine which , like muscarinic agonists depress cardiac contractility , did not affect inositol phosphate accumulation at concentrations up to 10 ( -4 ) m . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
14,
23
]
} | {
"id": "C0031484",
"name": "l",
"pos": [
207,
208
]
} |
however , the adenosine analogues , l-n6-phenylisopropyladenosine and 5 ' n-ethylcarboxamidoadenosine which , like muscarinic agonists depress cardiac contractility , did not affect inositol phosphate accumulation at concentrations up to 10 ( -4 ) m . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
14,
23
]
} | {
"id": "C0050789",
"name": "5 ' n-ethylcarboxamidoadenosine",
"pos": [
70,
101
]
} |
different opioid peptides , related to the enkephalins , dynorphins and beta-endorphin have also been detected in tissues outside the cns including the adrenal medulla and in pheochromocytomas . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
10,
25
]
} | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
43,
54
]
} |
different opioid peptides , related to the enkephalins , dynorphins and beta-endorphin have also been detected in tissues outside the cns including the adrenal medulla and in pheochromocytomas . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
10,
25
]
} | {
"id": "C0013355",
"name": "dynorphins",
"pos": [
57,
67
]
} |
determination of plasma [ 18f ] -6-fluorodopa during positron emission tomography : elimination and metabolism in carbidopa treated subjects . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
84,
95
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
100,
110
]
} |
in 67 patients ( mean age 51 years , range 26-79 ) , at diagnosis of primary haemochromatosis ( ph ) , grade iii or iv liver iron overload was present in all cases , cirrhosis in 85 % , transferrin saturation greater than 80 % in 75 % , serum ferritin greater than 1000 micrograms/l in 84 % , and overt diabetes in 48 % ... | NA | {
"id": "C0018995",
"name": "haemochromatosis",
"pos": [
77,
93
]
} | {
"id": "C0282193",
"name": "iron overload",
"pos": [
125,
138
]
} |
the fenamates ( flufenamic acid , meclofenamic acid , mefenamic acid , tolfenamic acid ) are , with the exception of mefenamic acid , not as widely prescribed as other groups of nsaids . | NA | {
"id": "C1955898",
"name": "fenamates",
"pos": [
4,
13
]
} | {
"id": "C0016282",
"name": "flufenamic acid",
"pos": [
16,
31
]
} |
the fenamates ( flufenamic acid , meclofenamic acid , mefenamic acid , tolfenamic acid ) are , with the exception of mefenamic acid , not as widely prescribed as other groups of nsaids . | NA | {
"id": "C1955898",
"name": "fenamates",
"pos": [
4,
13
]
} | {
"id": "C0025042",
"name": "meclofenamic acid",
"pos": [
34,
51
]
} |
the fenamates ( flufenamic acid , meclofenamic acid , mefenamic acid , tolfenamic acid ) are , with the exception of mefenamic acid , not as widely prescribed as other groups of nsaids . | NA | {
"id": "C1955898",
"name": "fenamates",
"pos": [
4,
13
]
} | {
"id": "C0025152",
"name": "mefenamic acid",
"pos": [
117,
131
]
} |
in this review , adverse reactions and interactions associated with the use of the newer cephalosporins and cephamycins are surveyed ; | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
89,
103
]
} | {
"id": "C0007736",
"name": "cephamycins",
"pos": [
108,
119
]
} |
monoclonal antibodies designed for a specific antigen resolved the problem of polyclonality and cross-reactivity of traditional antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
128,
138
]
} |
with a history of potentially toxic ingestion of an adsorbable drug , a charcoal stool following administration of oral activated charcoal should be a minimum requirement for discharge of the patient . | NA | {
"id": "C0007955",
"name": "charcoal",
"pos": [
72,
80
]
} | {
"id": "C0001275",
"name": "activated charcoal",
"pos": [
120,
138
]
} |
ethylene glycol is metabolised more rapidly than methanol , via alcohol dehydrogenase to glycolaldehyde which is rapidly metabolised to glycolate , the metabolite mainly responsible for the metabolic acidosis in ethylene glycol poisoning . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
49,
57
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
64,
71
]
} |
ethanol is also metabolised by alcohol dehydrogenase , but has a much higher affinity for this enzyme than methanol and ethylene glycol . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
0,
7
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
107,
115
]
} |
presence of ethanol will therefore inhibit formation of toxic metabolites from methanol and ethylene glycol . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
12,
19
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
79,
87
]
} |
a three-factor analysis of variance ( 2 x 2 x 2 ) demonstrated that there was a significant ( p less than 0.05 ) gender effect ( males greater than females ) , but no steroid or exercise main effects for tc . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
113,
119
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
150,
155
]
} |
antiserum 18d recognized the junction between the insulin b-chain and c-peptide and provided fivefold greater sensitivity than our previously reported hpi assay . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
70,
79
]
} | {
"id": "C0033362",
"name": "hpi",
"pos": [
151,
154
]
} |
this assay will be useful for confirming the diagnosis of insulin-secreting tumor in patients suspected of recurrent fasting hypoglycemia and in physiologic studies of proinsulin secretion . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
58,
65
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
168,
178
]
} |
this study examined the possibility that dopaminergic binding sites exist in the human adrenal cortex using [ 3h ] spiperone , a butyrophenone with high affinity for dopaminergic receptors of the d2 subtype . | NA | {
"id": "C0037956",
"name": "spiperone",
"pos": [
115,
124
]
} | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
129,
142
]
} |
these six amino acids plus aspartic acid , glutamic acid , and glycine supported growth of e. corrodens in a medium containing only inorganic salts and vitamins . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
10,
21
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
63,
70
]
} |
both p. aeruginosa and p. aureofaciens grew upon dihydrouracil , dihydrothymine , uridine and cytidine as either a sole nitrogen or carbon source while uracil , thymine and cytosine served only as sole nitrogen sources for both pseudomonads . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
56,
62
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
161,
168
]
} |
from these results it was concluded that ruthenium red stains the o-specific polysaccharide chains of lps . | NA | {
"id": "C0069180",
"name": "o-specific polysaccharide",
"pos": [
66,
91
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
102,
105
]
} |
electron microscopy showed the abundance of fibroblasts with conspicuous collagen and reticulin fibers together with numerous cells sharing the characteristics of both fibroblasts and smooth muscle cells ( myofibroblasts ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
126,
131
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
209,
220
]
} |
these results indicate that the anf receptor from bovine adrenal cortex is a membrane protein with a total molecular weight of 110,000-130,000 and suggest that the native protein contains only one single polypeptide chain . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
77,
93
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
171,
178
]
} |
these results suggest that the effect of eccles ' anions is profoundly modified by their counter-ions and that na+ and ammonium are acting through distinct sites on the glycine receptor . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
50,
56
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
97,
101
]
} |
the order of apparent binding affinities in a series of nucleoside 5'-triphosphates was gtp gamma s greater than gtp approximately bupgtp greater than dgtp approximately itp much greater than atp , values which were 30-100 times higher than affinities of the corresponding 5'-diphosphates . | NA | {
"id": "C0079469",
"name": "gtp",
"pos": [
88,
91
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
152,
155
]
} |
ly195115-sensitive pde measured in the various membrane fractions correlated well with the sarcoplasmic reticulum marker ca2+-atpase ( r = 0.94 ; p less than 0.001 ) , but not with na+ , k+-atpase or azide-sensitive atpase . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
181,
183
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
216,
222
]
} |
the immunoglobulin-adenovirus recombinant is helper independent in infecting human fibroblastic and b- and t-cell lines and expresses mu in a cell-type-specific manner . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
83,
95
]
} | {
"id": "C0007634",
"name": "cell-type",
"pos": [
142,
151
]
} |
in contrast , after transfection of these chimeric promoter recombinants into 293 cells ( which constitutively express the eia proteins ) , we found that their relative levels of transcription are similar and markedly different from those observed when they are cotransfected into hela cells with eia protein-producing r... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
127,
135
]
} | {
"id": "C0034861",
"name": "protein",
"pos": [
301,
308
]
} |
this autonomous low-molecular-weight dna species could be specifically amplified by cycloheximide treatment and was shown by isopycnic centrifugation in cesium chloride-ethidium bromide to consist predominantly of covalently closed circular dna molecules . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
37,
40
]
} | {
"id": "C0012925",
"name": "circular",
"pos": [
232,
240
]
} |
as judged by positive hybridization-translation and northern blot analyses , the central linked gene encodes a keratin , k17 , which is expressed in abundance with k14 and two other type i keratins in cultured human epidermal cells . | NA | {
"id": "C0010803",
"name": "keratin",
"pos": [
111,
118
]
} | {
"id": "C1179970",
"name": "type i keratins",
"pos": [
182,
197
]
} |
when cultured in the presence of retinoic acid , p19 ( ras+ ) cells differentiated and developed into the same spectrum of differentiated cell types as the parental p19 cells ( namely , neurons , astrocytes , and fibroblast-like cells ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
62,
67
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
213,
223
]
} |
most of the p19 ( ras+ ) -derived differentiated cells contained relatively low levels of p21ej and were nontransformed , whereas certain cells with fibroblast-like morphology continued to express the ha-rasej-1 gene at high levels and were transformed ( i.e. , immortal and anchorage independent ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
49,
54
]
} | {
"id": "C0016030",
"name": "cells",
"pos": [
138,
143
]
} |
fibroblasts derived from p19 cells did not become transformed following transfection of the ha-rasej-1 oncogene , suggesting that transformation of the fibroblast cells only occurred if the oncogene was present and expressed during the early stages of the developmental lineage . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
29,
34
]
} | {
"id": "C0016030",
"name": "fibroblast cells",
"pos": [
152,
168
]
} |
the ability of the encoded p21 's to autophosphorylate , bind guanine nucleotides , and hydrolyze gtp was assessed . | NA | {
"id": "C0018328",
"name": "guanine",
"pos": [
62,
69
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
98,
101
]
} |
by comparison of the coding sequences of different p21 proteins recognized by this monoclonal antibody , a highly conserved amino acid region between positions 70 and 81 was found to be the most likely site for the epitope detected by the y13-259 antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
83,
102
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
247,
255
]
} |
introduction of the hla-b8 gene failed to restore antigen expression by hla-b-null mutant .174 , providing evidence that , unlike mutants exemplified by .53 , .144 , and .184 , some hla antigen loss mutants are deficient in a trans-acting function needed for class i antigen expression . | NA | {
"id": "C0019746",
"name": "hla-b8",
"pos": [
20,
26
]
} | {
"id": "C0019737",
"name": "antigen",
"pos": [
267,
274
]
} |
introduction of the hla-b8 gene failed to restore antigen expression by hla-b-null mutant .174 , providing evidence that , unlike mutants exemplified by .53 , .144 , and .184 , some hla antigen loss mutants are deficient in a trans-acting function needed for class i antigen expression . | NA | {
"id": "C0019737",
"name": "antigen",
"pos": [
50,
57
]
} | {
"id": "C0019721",
"name": "hla antigen",
"pos": [
182,
193
]
} |
comparison of the ltr sequences possessed by two particular vl30 dna elements revealed a pattern of extensively homologous dna segments adjacent to only distantly related dna sequences . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
65,
68
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
173,
174
]
} |
we conclude that the v-erb-b protein spans the plasma membrane in a manner similar or identical to that of the epidermal growth factor receptor , even though the viral transforming protein does not possess the signal peptide that is thought to direct insertion of the receptor into the membrane . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
29,
36
]
} | {
"id": "C0042736",
"name": "viral",
"pos": [
162,
167
]
} |
in vitro the enzyme cleaved host chlorella nuclear dna but not viral dna because host dna contains gatc and pbcv-1 dna contains gmatc sequences . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
63,
72
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
115,
118
]
} |
to reduce the constitutive transposase activity observed for the icarus element , we attenuated the translational efficiency of the transposase rna by inserting the transposon 5 neomycin resistance gene between the hsp70 promoter and the p-element sequences . | NA | {
"id": "C0013879",
"name": "element",
"pos": [
72,
79
]
} | {
"id": "C0031705",
"name": "p-element",
"pos": [
238,
247
]
} |
f2 had a deletion of the codon for alanine at amino acid residue-5 in the invertase signal and an addition of a methionine codon located between the coding sequences for the invertase signal and mature huifn-alpha 2 . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
35,
42
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
46,
56
]
} |
when the proteins encoded by the mutant ras genes were overproduced in escherichia coli , several mutant proteins that lacked met-72 failed to bind y13-259 in a western blot . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
9,
17
]
} | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
98,
113
]
} |
the phorbol ester 12-o-tetradecanoylphorbol-13-acetate ( tpa ) induced megakaryoblastic differentiation and c-sis expression in the human hematopoietic stem cell line k-562 . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
4,
17
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
18,
54
]
} |
it was bound to antibodies against a peptide corresponding to the carboxy terminus of medium t and released from the immune complex with an excess of the same peptide . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
16,
26
]
} | {
"id": "C0003313",
"name": "immune complex",
"pos": [
117,
131
]
} |
however , the introduction of a ras oncogene together with a selectable neomycin resistance marker into refs allowed killing of the normal nontransfected cells and the outgrowth of colonies of ras transformants , 10 % of which survived crisis and became tumorigenic . | NA | {
"id": "C0016030",
"name": "refs",
"pos": [
104,
108
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
132,
138
]
} |
rat embryo fibroblast cell line 6 was transfected with plasmid pt24 , which contains the activated human bladder c-ha-ras oncogene , and the cells were grown continuously in the absence or presence of the tumor promoters 12-o-tetradecanoyl phorbol-13-acetate ( tpa ) or teleocidin . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
11,
21
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
141,
146
]
} |
ansamitocin , another benzenoid ansamycin , and naphthalenoid ansamycins such as streptovaricin and rifamycins did not show this effect . | NA | {
"id": "C0140575",
"name": "ansamycin",
"pos": [
32,
41
]
} | {
"id": "C0038430",
"name": "streptovaricin",
"pos": [
81,
95
]
} |
ansamitocin , another benzenoid ansamycin , and naphthalenoid ansamycins such as streptovaricin and rifamycins did not show this effect . | NA | {
"id": "C0140575",
"name": "ansamycin",
"pos": [
32,
41
]
} | {
"id": "C0035609",
"name": "rifamycins",
"pos": [
100,
110
]
} |
the immune complex prepared by mixing the herbimycin-treated cell extracts with antibody against p60src was inactive in vitro in phosphorylating the complex itself . | NA | {
"id": "C0003313",
"name": "immune complex",
"pos": [
4,
18
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
80,
88
]
} |
human gamma interferon genomic dna was introduced into nih 3t3 fibroblasts by calcium phosphate precipitation and was not expressed in these cells at the cytoplasmic mrna or protein level . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
63,
74
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
141,
146
]
} |
altogether , these observations suggest that , in contrast with the model of fibroblast growth mentioned above , el2 cells require the presence of a single growth factor ( egf ) for induction of dna synthesis , and the expression of myc and fos proto-oncogenes may represent an obligatory step in the pathway of commitme... | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
77,
87
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
297,
300
]
} |
therefore , in infected cells , the mutant icp4 gene product appears to be the primary defect which leads to the block in nuclear localization of the other proteins . | NA | {
"id": "C1564139",
"name": "mutant",
"pos": [
36,
42
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
156,
164
]
} |
proteinase a shows substantial homology to mammalian aspartyl proteases , such as pepsin , renin , and cathepsin d . | NA | {
"id": "C0078989",
"name": "aspartyl proteases",
"pos": [
53,
71
]
} | {
"id": "C0030909",
"name": "pepsin",
"pos": [
82,
88
]
} |
proteinase a shows substantial homology to mammalian aspartyl proteases , such as pepsin , renin , and cathepsin d . | NA | {
"id": "C0078989",
"name": "aspartyl proteases",
"pos": [
53,
71
]
} | {
"id": "C0035094",
"name": "renin",
"pos": [
91,
96
]
} |
proteinase a shows substantial homology to mammalian aspartyl proteases , such as pepsin , renin , and cathepsin d . | NA | {
"id": "C0078989",
"name": "aspartyl proteases",
"pos": [
53,
71
]
} | {
"id": "C0007427",
"name": "cathepsin d",
"pos": [
103,
114
]
} |
when maximally ribosome associated , this protein was found to be on the small subunit in a 1:1 stoichiometric ratio with other ribosomal proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
42,
49
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
128,
146
]
} |
we used computerized microdensitometry of 2-dimensional protein profiles to measure the relative rates of synthesis and abundance of the individual tm isoforms and actin , the two major structural constituents of microfilaments . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
56,
63
]
} | {
"id": "C0597298",
"name": "isoforms",
"pos": [
151,
159
]
} |
the presence in normal chicken embryo fibroblasts and in chicken kidney of two transcripts , 3.7 and 3.9 kilobases in length , that hybridize with a yes-specific dna probe , as well as the two proteins recognized by anti-yes igg , suggests either differential splicing of cellular yes gene transcripts or the existence o... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
38,
49
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
272,
280
]
} |
in a second class , the rate of synthesis of odc polypeptide per odc mrna was at least four- to eightfold higher than that in wild-type cells . | NA | {
"id": "C0007054",
"name": "odc",
"pos": [
45,
48
]
} | {
"id": "C0029282",
"name": "odc",
"pos": [
65,
68
]
} |
this change in activity was associated with modification of the rate of synthesis and degradation of odc but no change in the level of odc mrna . | NA | {
"id": "C0007054",
"name": "odc",
"pos": [
101,
104
]
} | {
"id": "C0029282",
"name": "odc",
"pos": [
135,
138
]
} |
dna molecules with stable cruciform structures were generated by heteroduplexing this dna fragment with mutants altered within the palindromic sequence ( c. nobile and r. g. martin , int . virol. , in press ) . | NA | {
"id": "C1258072",
"name": "dna",
"pos": [
0,
3
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
86,
89
]
} |
the conservation of the repetitive rnp consensus sequence suggests an important function and a common evolutionary origin for messenger rnp and heterogeneous nuclear rnp proteins . | NA | {
"id": "C0035668",
"name": "rnp",
"pos": [
35,
38
]
} | {
"id": "C0035696",
"name": "messenger rnp",
"pos": [
126,
139
]
} |
while the v-myc vector by itself had no apparent effect on lymphoid culture establishment and growth , infection with the v-ha-ras vector or coinfection with both v-myc and v-ha-ras vectors led to the appearance of growth-stimulated cell populations . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
103,
112
]
} | {
"id": "C0275524",
"name": "coinfection",
"pos": [
141,
152
]
} |
the synthesis of each surface protein was greatly reduced within 1 h and undetectable by 2 h after a shift to the temperature at which the protein is not expressed . | NA | {
"id": "C0025252",
"name": "surface protein",
"pos": [
22,
37
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
139,
146
]
} |
surface protein synthesis resumed by the end of 1 h after a shift to the temperature at which the protein is expressed . | NA | {
"id": "C0025252",
"name": "surface protein",
"pos": [
0,
15
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
98,
105
]
} |
mf30 was found to bind with high specificity to hldh5 when the enzyme was adsorbed onto a polystyrene plate but did not recognize the isoenzyme when in solution . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
63,
69
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
134,
143
]
} |
when used as capture antibodies adsorbed on plastic at equal concns , the best monoclonal antibodies were 1/8- less than 1/16 as effective as their polyclonal counterparts in binding iodinated bovine immunoglobulins ; | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
21,
31
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
79,
100
]
} |
structurally diverse dextrans from leuconostoc mesenteroides and related bacteria have been used extensively in fundamental immunochemical studies such as induction and characterization of anti-dextran antibodies , as well as in studies of their interaction with pneumococcal antisera , normal bovine serum , concanavali... | NA | {
"id": "C0011806",
"name": "dextrans",
"pos": [
21,
29
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
326,
333
]
} |
structurally diverse dextrans from leuconostoc mesenteroides and related bacteria have been used extensively in fundamental immunochemical studies such as induction and characterization of anti-dextran antibodies , as well as in studies of their interaction with pneumococcal antisera , normal bovine serum , concanavali... | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
276,
284
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
380,
390
]
} |
proper interpretation of past and future studies necessitates pointing out previous inadequacies of dextran structural data and detailing more recently acquired structural information on the dextrans . | NA | {
"id": "C0086140",
"name": "dextran",
"pos": [
100,
107
]
} | {
"id": "C0011806",
"name": "dextrans",
"pos": [
191,
199
]
} |
phosphorus depleted or heparin treated experimental animals develop impairment of mineralisation as manifested by rickets or osteomalacia . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
114,
121
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
125,
137
]
} |
zs rnase ( 10 micrograms/ml ) caused 50 % inhibition of mlc reaction whereas pancreatic ribonuclease ( a rnase ) was 10 times less effective . | NA | {
"id": "C0035541",
"name": "pancreatic",
"pos": [
77,
87
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
105,
110
]
} |
aneuploidy represents the predominant type of chromosomal abnormality found in human newborns with birth defects . | NA | {
"id": "C0002938",
"name": "aneuploidy",
"pos": [
0,
10
]
} | {
"id": "C0008626",
"name": "of chromosomal abnormality",
"pos": [
43,
69
]
} |
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