text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
to study the metabolic acidosis that occurs during the diarrhea of cholera , we examined the serum anion gap in 21 patients with hypovolemic shock due to vibrio cholerae infection . | NA | {
"id": "C0042636",
"name": "due to vibrio",
"pos": [
147,
160
]
} | {
"id": "C0008354",
"name": "cholerae",
"pos": [
161,
169
]
} |
measurements of serum electrolytes , as well as divalent cations and the anionic contributions of serum proteins , lactate , phosphate , and serum creatinine , were made at the time of admission , after rehydration , and during convalescence . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
73,
80
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
125,
134
]
} |
to the extent that the difference in concordance rates between monozygotic and dizygotic twins indicates genetic susceptibility , the results of this study show a major genetic component in susceptibility to multiple sclerosis . | NA | {
"id": "C0314657",
"name": "genetic susceptibility",
"pos": [
105,
127
]
} | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
190,
204
]
} |
complementary dna for a novel human interleukin ( bsf-2 ) that induces b lymphocytes to produce immunoglobulin . | NA | {
"id": "C0021764",
"name": "interleukin",
"pos": [
36,
47
]
} | {
"id": "C0021760",
"name": "bsf-2",
"pos": [
50,
55
]
} |
the primary sequence of bsf-2 deduced from the cdna reveals that bsf-2 is a novel interleukin consisting of 184 amino acids . | NA | {
"id": "C0021760",
"name": "bsf-2",
"pos": [
24,
29
]
} | {
"id": "C0021764",
"name": "interleukin",
"pos": [
82,
93
]
} |
these ligands have been used to demonstrate high affinity dissociation constant ( approximately 10 ( -10 ) m ) specific binding sites on pig chondrocytes and synovial fibroblasts , human dermal fibroblasts and murine osteoblasts ( 3,000-5,000 sites per cell ) . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
141,
153
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
253,
257
]
} |
these ligands have been used to demonstrate high affinity dissociation constant ( approximately 10 ( -10 ) m ) specific binding sites on pig chondrocytes and synovial fibroblasts , human dermal fibroblasts and murine osteoblasts ( 3,000-5,000 sites per cell ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
167,
178
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
253,
257
]
} |
three splicing complexes formed with a yeast pre-messenger rna during in vitro splicing can be resolved by non-denaturing gel electrophoresis after incubation in the presence of non-specific competitor rna . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
49,
62
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
202,
205
]
} |
here we report that microinjection of purified protein kinase c into swiss 3t3 fibroblasts pretreated with the phorbol ester phorbol 12,13-dibutyrate ( pdbu ) restores the mitogenic response of the cells to pdbu , directly establishing the involvement of protein kinase c in this response . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
79,
90
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
236,
239
]
} |
sm-fesv does not induce haematopoietic malignancies in spite of the fact that its viral oncogene , v-fms , codes for a glycoprotein related to the receptor for the mononuclear phagocyte colony stimulating factor , csf-1 . | NA | {
"id": "C0009392",
"name": "colony stimulating factor",
"pos": [
186,
211
]
} | {
"id": "C0079784",
"name": "csf-1",
"pos": [
214,
219
]
} |
if the water activity is reduced on addition of salt or organic solvents , transformation occurs to a-dna or , in dnas with alternating purine-pyrimidine sequences , to the left-handed z-dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
102,
105
]
} | {
"id": "C0043442",
"name": "left-handed",
"pos": [
173,
184
]
} |
in crystal structure analyses of oligonucleotides , the free oxygen atoms of adjacent phosphate groups along the polynucleotide chain in b-dna are found at least 6.6 a apart and individually hydrated whereas they are as close as 5.3 a in a-dna and 4.4 a in z-dna , and bridged by water molecules . | NA | {
"id": "C0028953",
"name": "oligonucleotides",
"pos": [
33,
49
]
} | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
113,
127
]
} |
we suggest that this more economical hydration in a- and z-dna compared with b-dna is the underlying cause of b -- -- a and b -- -- z transitions . | NA | {
"id": "C0043442",
"name": "z-dna",
"pos": [
57,
62
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
79,
82
]
} |
in mammalian cells , haemin is degraded to carbon monoxide and bilirubin by the enzyme haeme oxygenase . | NA | {
"id": "C0018988",
"name": "haemin",
"pos": [
21,
27
]
} | {
"id": "C0018966",
"name": "haeme",
"pos": [
87,
92
]
} |
using a chemical detection method , a search for previously unknown peptides that possess the c-terminal amide structure in extracts of brain and intestine was carried out and a number of novel neuropeptides and hormonal peptides , designated neuropeptide y , phi , peptide yy , galanin and neuropeptide k were isolated ... | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
194,
207
]
} | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
243,
257
]
} |
using a chemical detection method , a search for previously unknown peptides that possess the c-terminal amide structure in extracts of brain and intestine was carried out and a number of novel neuropeptides and hormonal peptides , designated neuropeptide y , phi , peptide yy , galanin and neuropeptide k were isolated ... | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
194,
207
]
} | {
"id": "C0060993",
"name": "galanin",
"pos": [
279,
286
]
} |
we have discovered striking homology between p-glycoprotein and the hlyb protein , a 66k escherichia coli membrane protein required for the export of haemolysin ( protein of mr 107k ) . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
106,
122
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
163,
170
]
} |
these findings indicate that genetically diverse hiv-1 isolates carry both variable and widely conserved antigenic epitopes for neutralizing antibodies . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
105,
114
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
115,
123
]
} |
recognition of cells that express nucleoprotein by ctl does not depend on a definite signal sequence within the protein , and the epitopes recognized can be defined with short synthetic peptides in vitro . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
34,
47
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
112,
119
]
} |
isosorbide-5-mononitrate ( is-5-mn ) , the main metabolite of isosorbide dinitrate shows antianginal efficacy and is being used increasingly as a drug for practical therapy . | NA | {
"id": "C0064079",
"name": "isosorbide-5-mononitrate",
"pos": [
0,
24
]
} | {
"id": "C0022252",
"name": "isosorbide dinitrate",
"pos": [
62,
82
]
} |
the accumulation of 3-methoxytyramine ( 3-mt ) , the o-methylated metabolite of dopamine ( da ) , in rat striatum was used to assess the effects of drugs on dopaminergic activity . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
80,
88
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
157,
169
]
} |
adrenaline 1 nmol/l increased overflow , but at high concentrations it reduced it , just as noradrenaline did at all concentrations . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
92,
105
]
} |
unlike various neuropeptides ( substance p , kassinin , neurokinin a , cholecystokinin octapeptide , somatostatin , vasoactive intestinal polypeptide ) only the calcitonin gene-related peptide ( cgrp ) closely mimicked , both qualitatively and quantitatively , the capsaicin-induced relaxations . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
15,
28
]
} | {
"id": "C0006669",
"name": "cgrp",
"pos": [
195,
199
]
} |
the substance p antagonists ( d-pro2 , d-trp7,9 ) sp ( 10 and 30 microm ) and ( arg5 , d-trp7,9 , nle11 ) sp5-11 ( 1 and 10 microm ) competitively antagonized both the contractile effects of substance p and eledoisin , and the inhibition by the tachykinins of the electrically-evoked release of [ 3h ] acetylcholine . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
4,
15
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
245,
256
]
} |
intraventricular administration of histamine ( ha ; 2.5 and 5 micrograms ) caused a significant increase of plasma adrenaline and noradrenaline levels in conscious , freely-moving male rats . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
115,
125
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
130,
143
]
} |
the increase of adrenaline was more rapid ( 5 min after injection ) and greater than that of noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
16,
26
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
93,
106
]
} |
in contrast , it was ineffective on plasma adrenaline at 5 min and plasma noradrenaline increase . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
43,
53
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
74,
87
]
} |
ranitidine , an h2-receptor antagonist , did not modify adrenaline response but enhanced the ha-induced increase of plasma noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
56,
66
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
123,
136
]
} |
selective iodination of whole cells followed by electrophoresis and autoradiography indicated that of the major proteins , only 25 % of neuronal and 60 % of astroglial and oligodendroglial membrane proteins were exposed outside the cell surface . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
112,
120
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
189,
206
]
} |
during this phase of rapid myelination the proportions of c 16:0 and c 18:0 fatty acids decreased whereas the relative amounts of long chain and unsaturated fatty acids increased in most lipid classes . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
76,
87
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
145,
168
]
} |
further studies are being conducted on bmn , including also other markers ( ca 125 , ca 199 ) , with monoclonal antibodies , beta-endorphins and prostaglandins in neurological diseases , including multiple sclerosis . | NA | {
"id": "C0041366",
"name": "bmn",
"pos": [
39,
42
]
} | {
"id": "C0005516",
"name": "markers",
"pos": [
66,
73
]
} |
acute administration of n6 ( l-phenylisopropyl ) adenosine ( l-pia ; 0.01-0.178 mg/kg , s.c. ) , n6-cyclohexyladenosine ( cha ; 0.01-0.178 mg/kg , s.c. ) , 2-chloroadenosine ( 2-ca ; 0.32-0.56 mg/kg , s.c. ) , n6-cycloheptyladenosine ( chpa ; 0.032-1.0 mg/kg , s.c. ) , n6-phenyladenosine ( pa ; 0.1-1.0 mg/kg , s.c. ) ,... | NA | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
156,
173
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
403,
412
]
} |
dynorphin and [ d-ala2-d-leu ] enkephalin ( dadle ) were administered directly into the cerebrolateral ventricles of rats and effects on various indices of sensorimotor function and retention of a passive avoidance task were measured . | NA | {
"id": "C0014294",
"name": "leu ] enkephalin",
"pos": [
25,
41
]
} | {
"id": "C0079286",
"name": "dadle",
"pos": [
44,
49
]
} |
brief incubations with either acetylcholinesterase or trypsin cleaved chromogranin a to yield two chromogranin-immunoreactive polypeptides which were similar in molecular weight to two of the major endogenous chromogranin polypeptides . | NA | {
"id": "C0055633",
"name": "chromogranin a",
"pos": [
70,
84
]
} | {
"id": "C0008586",
"name": "chromogranin",
"pos": [
209,
221
]
} |
more prolonged digestion of chromogranin a with acetylcholinesterase produced a large number of peptides which were similar to some of the endogenous chromogranin peptides in their elution profile by high performance liquid chromatography . | NA | {
"id": "C0055633",
"name": "chromogranin a",
"pos": [
28,
42
]
} | {
"id": "C0008586",
"name": "chromogranin",
"pos": [
150,
162
]
} |
they also suggest that acetylcholinesterase , an enzyme found in chromaffin cells , may process chromogranin a to yield lower molecular weight chromogranins in bovine chromaffin cells . | NA | {
"id": "C0055633",
"name": "chromogranin a",
"pos": [
96,
110
]
} | {
"id": "C0008586",
"name": "chromogranins",
"pos": [
143,
156
]
} |
capsaicin induced release of multiple tachykinins ( substance p , neurokinin a and eledoisin-like material ) from guinea-pig spinal cord and ureter . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
38,
49
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
52,
63
]
} |
capsaicin induced release of multiple tachykinins ( substance p , neurokinin a and eledoisin-like material ) from guinea-pig spinal cord and ureter . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
38,
49
]
} | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
66,
78
]
} |
when wheat germ agglutinin conjugated with horseradish peroxidase ( wga-hrp ) is injected into a hindlimb nerve it is first transported to motoneuronal somata and then , transneuronally , to interneurones in several spinal segments . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
43,
65
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
68,
75
]
} |
in contrast , etorphine , dadl ( [ d-ala2 , d-leu5 ] -enkephalin ) and dago ( [ d-ala2 , mephe4 , gly-ol5 ] -enkephalin ) , up to 1 microm concentrations failed to affect pi turnover in both cell lines . | NA | {
"id": "C0525773",
"name": "dago",
"pos": [
71,
75
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
109,
119
]
} |
maternal weight gained during the dosing period was decreased in a dose-related manner , but there were no dose-related differences in offspring body weights . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
9,
15
]
} | {
"id": "C0005911",
"name": "differences",
"pos": [
120,
131
]
} |
hydrocortisone was shown to decrease in the derma of young animals the number of fibroblasts , which actively produce collagen , and to increase the number of fibrocytes and degenerating cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
81,
92
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
187,
192
]
} |
this led us to use systemic tetracycline ( oral tetracycline hydrochloride 1 g daily divided into 4 doses ) as adjunctive therapy in treating 18 patients with persistent corneal epithelial defects . | NA | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
28,
40
]
} | {
"id": "C0546879",
"name": "tetracycline hydrochloride",
"pos": [
48,
74
]
} |
stress was voluntarily mentioned by respondents as a major cause of pain in headaches , backaches , stomach pains , and menstrual pains , but not for muscle , joint or dental pains . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
68,
72
]
} | {
"id": "C0018681",
"name": "headaches",
"pos": [
76,
85
]
} |
when compared with 43.0 +/- 9.4 dark neurons , which were seen in animals without alkaloid treatment , colchicine , vinblastine and vincristine significantly reduced the transsynaptic degeneration by 86 , 43 , and 78 % , respectively . | NA | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
82,
90
]
} | {
"id": "C0009262",
"name": "colchicine",
"pos": [
103,
113
]
} |
[ heterogeneity of populations of the mollusc bithynia inflata according to the degree of trematode infestation in opisthorchiasis foci ] . | NA | {
"id": "C0040820",
"name": "trematode infestation",
"pos": [
90,
111
]
} | {
"id": "C0029106",
"name": "opisthorchiasis",
"pos": [
115,
130
]
} |
experiments to investigate the linked metabolism of l-serine and l-alanine by moniliformis moniliformis in vitro were carried out by incubating adult worms aerobically for 3 h at 37 degrees c in tyrode 's solution containing l- [ u-14c ] alanine and other amino acids . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
67,
74
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
256,
267
]
} |
when present in the medium with serine and no other amino acids , alanine was largely metabolized as before but additional alanine , believed to originate from serine , was excreted . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
52,
63
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
123,
130
]
} |
as it occurs with most of 3rd generation cephalosporins , ceftriaxone has few , if any , interactions with penicillinase-type beta-lactamases , such as tem-1 , tem-2 or pit-2 . | NA | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
107,
120
]
} | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
126,
141
]
} |
conversely , ceftriaxone , as cefotaxime , shows a high affinity for chromosomally-mediated cephalosporinases ( indole-positive proteus , enterobacter , pseudomonas ... ) , which is characterized by ki values ranging from about 0.05 to 1 microm . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
13,
24
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
30,
40
]
} |
within these beta-lactamases , the hydrolysis of ceftriaxone , as that of cefotaxime , is always low , but significant . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
49,
60
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
74,
84
]
} |
then few beta-lactamases are able to hydrolyze more efficiently cefotaxime , as cefuroxime , such as those produced by p vulgaris and k oxytoca . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
64,
74
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
80,
90
]
} |
within these enzymes , ceftriaxone is also hydrolyzed , in a way quite similar to that of cefotaxime . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
23,
34
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
90,
100
]
} |
the rheumatic diseases , including juvenile rheumatoid arthritis , the spondyloarthropathies , rheumatic fever , lupus erythematosus , dermatomyositis , and the various vasculitis syndromes all can cause arthritis ; | NA | {
"id": "C0035436",
"name": "rheumatic",
"pos": [
4,
13
]
} | {
"id": "C0003864",
"name": "arthritis",
"pos": [
204,
213
]
} |
we conclude that child restraint devices are effective in reducing motor vehicle accident fatalities and injuries in young children and the child restraint law has been effective in increasing child restraint usage and in reducing childhood death and injury in new mexico . | NA | {
"id": "C0728836",
"name": "young",
"pos": [
117,
122
]
} | {
"id": "C0008059",
"name": "child",
"pos": [
231,
236
]
} |
the first method depends on the dye-salt formation method using tropeolin ooo as the anionic dye and 1,2-dichloroethane as solvent for the extraction of the formed ion pairs . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
85,
92
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
164,
167
]
} |
channel openings caused by gtp faded by removing mg2+ , while gtp-gamma s-induced openings persisted steadily even when both mg2+ and gtp-gamma s were removed . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
27,
30
]
} | {
"id": "C0079469",
"name": "gtp-gamma s",
"pos": [
134,
145
]
} |
in contrast to the case of gtp-induced channel openings , the gtp-gamma s-induced openings were not inhibited by the a promoter of pertussis toxin with nad . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
27,
30
]
} | {
"id": "C0079469",
"name": "gtp-gamma s",
"pos": [
62,
73
]
} |
phycobilisomes , the major light-harvesting complexes of cyanobacteria are multimolecular structures made up of chromophoric proteins called phycobiliproteins and non chromophoric linker polypeptides . | NA | {
"id": "C0136979",
"name": "phycobilisomes",
"pos": [
0,
14
]
} | {
"id": "C0070980",
"name": "phycobiliproteins",
"pos": [
141,
158
]
} |
we report here the isolation and nucleotide sequence of the genes , cpea and cpeb , which in calothrix pcc 7601 encode the alpha and beta subunits of phycoerythrin , one of the major phycobiliproteins . | NA | {
"id": "C0031789",
"name": "phycoerythrin",
"pos": [
150,
163
]
} | {
"id": "C0070980",
"name": "phycobiliproteins",
"pos": [
183,
200
]
} |
we describe a method for the construction of large dna fragment libraries in plasmid vectors , in which complementary , single-stranded extensions are ligated onto both vector and insert dna using un-phosphorylated adaptor oligonucleotides . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
12,
13
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
187,
190
]
} |
our results demonstrate that the glu 111 -- -- gln , glu 144 -- -- gln and arg 145 -- -- lys -mutants adopt a very similar conformation as the wild type enzyme , but have by two orders of magnitude smaller specific activities than the wild type enzyme , mainly due to a reduction of the vmax-value . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
33,
36
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
67,
70
]
} |
the victims who survive are left with paralysis , disfigurement , loss of sight and hearing , seizures , epilepsy , psychiatric disorders , amnesia -- in short , significant and often permanent impairment . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
94,
102
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
105,
113
]
} |
initial management of the patient with blunt cardiac trauma is the same as for any trauma patient : stabilization of airway , breathing , and circulation . | NA | {
"id": "C0043253",
"name": "blunt",
"pos": [
39,
44
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
83,
89
]
} |
[ infection and inflammation of the urinary tract : various cases of urinary tract infections investigated with the thomas ' test during forced water loading ] . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
2,
11
]
} | {
"id": "C0042029",
"name": "of urinary tract",
"pos": [
66,
82
]
} |
two highly differentiated acidophil prolactin-cell adenomas with hyperprolactinemia ( group i ) , 8 large cell chromophobe adenomas with hyperprolactinemia ( group ii ) , and 2 small cell chromophobe adenomas ( group iii ) , one of which was combined with hyperprolactinemia , were studied immunohistologically . | NA | {
"id": "C0033375",
"name": "prolactin-cell adenomas",
"pos": [
36,
59
]
} | {
"id": "C0001430",
"name": "adenomas",
"pos": [
200,
208
]
} |
two highly differentiated acidophil prolactin-cell adenomas with hyperprolactinemia ( group i ) , 8 large cell chromophobe adenomas with hyperprolactinemia ( group ii ) , and 2 small cell chromophobe adenomas ( group iii ) , one of which was combined with hyperprolactinemia , were studied immunohistologically . | NA | {
"id": "C0001430",
"name": "adenomas",
"pos": [
51,
59
]
} | {
"id": "C0001432",
"name": "chromophobe adenomas",
"pos": [
188,
208
]
} |
comparison of large cell chromophobe adenomas ( group ii ) , and small cell chromophobe adenomas ( group iii ) revealed significantly larger relative volumes of nuclei and of mitochondria but smaller volumes of rough endoplasmic reticulum and of golgi fields in the small cell chromophobe adenomas . | NA | {
"id": "C0001430",
"name": "adenomas",
"pos": [
37,
45
]
} | {
"id": "C0001432",
"name": "chromophobe adenomas",
"pos": [
277,
297
]
} |
in spite of the low quantity of small cell chromophobe adenomas and of acidophil prolactin cell adenomas , our data demonstrate that there exist distinct and significant light microscopical and ultrastructural differences between the three adenoma types . | NA | {
"id": "C0033375",
"name": "prolactin cell adenomas",
"pos": [
81,
104
]
} | {
"id": "C0001430",
"name": "adenoma",
"pos": [
240,
247
]
} |
statistical analyses of results by the method of lee and wesley indicated that the incidence of complete and partial regression ( cr and pr ) observed with d-trp-6-lh-rh was not significantly different from that recorded in previous studies for another lh-rh analog , buserelin . | NA | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
164,
169
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
268,
277
]
} |
the effect of estramustine [ estradiol 3-n-bis ( 2-chloroethyl ) carbamate ] on the human prostatic tumor cell line 1013l was investigated . | NA | {
"id": "C0014921",
"name": "estramustine",
"pos": [
14,
26
]
} | {
"id": "C0014912",
"name": "estradiol",
"pos": [
29,
38
]
} |
during the hours immediately following an hypertensive burst or a cerebral ischemia induced by the intracarotid administration of microspheres , damage to the blood brain barrier can be observed with molecules of low molecular weight , such as angiotensin , whereas albumin or large proteins will not yet have been able ... | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
266,
273
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
283,
291
]
} |
the determination of the intensity of hydroxyproline excretion can be used for the assessment of a degree of compensation of metabolic processes and the efficacy of therapeutic measures in diabetes mellitus . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
53,
62
]
} | {
"id": "C0025519",
"name": "metabolic processes",
"pos": [
125,
144
]
} |
the ratio of lipid and lipoprotein fractions depending on a degree of compensation , duration of disease and the presence of complications was disturbed in the blood serum and erythrocytic membranes of the diabetic children . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
13,
18
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
23,
34
]
} |
[ case of the syndrome of diabetes mellitus , diabetes insipidus , optic nerve atrophy , deafness and bladder atony ( didmoad syndrome ) ] . | NA | {
"id": "C0011848",
"name": "diabetes insipidus",
"pos": [
46,
64
]
} | {
"id": "C0043207",
"name": "didmoad syndrome",
"pos": [
118,
134
]
} |
neurohypophysial hormones stimulate the motility of tunica albuginea , epididymis , and vas deferens acting through oxytocin ( ot ) and v1 vasopressin receptors . | NA | {
"id": "C0032017",
"name": "neurohypophysial hormones",
"pos": [
0,
25
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
116,
124
]
} |
the nuclease resistance of these nucleoprotein acceptor sites from chromatin is a property similar to the nuclear matrix binding sites suggesting a relationship between these two classes of nuclear acceptor sites . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
33,
46
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
67,
76
]
} |
the laccase ( benzenediol : oxygen oxidoreductase , ec 1.10.3.2 ) gene from neurospora crassa was cloned and part of its nucleotide sequence corresponding to the carboxyl-terminal region of the protein has been determined . | NA | {
"id": "C0064566",
"name": "laccase",
"pos": [
4,
11
]
} | {
"id": "C0030016",
"name": "ec 1",
"pos": [
52,
56
]
} |
the presence of an initiator codon immediately preceding the codon for the nh2-terminal serine residue and of a terminator codon immediately following the codon for asp-109 , the cooh-terminal residue , suggests that prothymosin alpha is synthesized without formation of a larger precursor polypeptide . | NA | {
"id": "C0242610",
"name": "initiator codon",
"pos": [
19,
34
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
155,
160
]
} |
the presence of an initiator codon immediately preceding the codon for the nh2-terminal serine residue and of a terminator codon immediately following the codon for asp-109 , the cooh-terminal residue , suggests that prothymosin alpha is synthesized without formation of a larger precursor polypeptide . | NA | {
"id": "C0242611",
"name": "terminator codon",
"pos": [
112,
128
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
155,
160
]
} |
polyclonal and monoclonal anti-ifn-beta antibodies inhibit the increase in class i hla gene expression ( hla-b7 mrna ) in tnf-treated fs-4 cells suggesting that tnf-induced ifn-beta 2 mediates the enhancing effect of tnf on hla gene expression in human fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
139,
144
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
253,
264
]
} |
this region is followed by a c-terminal domain that is similar in size to the corresponding domains of the other steroid receptors and v-erba and shows striking amino acid homology with the glucocorticoid receptor and significant homology with the estrogen receptor . | NA | {
"id": "C0034840",
"name": "steroid receptors",
"pos": [
113,
130
]
} | {
"id": "C0034804",
"name": "estrogen receptor",
"pos": [
248,
265
]
} |
i have found that hsv-1 ( kos ) dna digested to completion with the restriction enzyme xba i is as efficient as intact viral dna in supporting the in vivo replication of cotransfected plasmids containing oris . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
32,
35
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
119,
128
]
} |
the diversity of the genes encoding mammalian proteoglycan peptide cores was explored using a cdna clone that encodes the partial sequence of a cell surface/pericellular matrix-localized chondroitin sulfate proteoglycan . | NA | {
"id": "C0033692",
"name": "proteoglycan",
"pos": [
46,
58
]
} | {
"id": "C0033689",
"name": "chondroitin sulfate proteoglycan",
"pos": [
187,
219
]
} |
competition studies made with tachykinins and substance p analogues indicated that the characteristics of the 125i-labeled bolton-hunter labeled substance p binding sites on glial cells were identical to those on rat brain synaptosomes . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
30,
41
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
145,
156
]
} |
animals trained to self-administer d-amphetamine , when given access to the l-try enriched diets , significantly reduced their daily amphetamine self-injection during exposure periods . | NA | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
35,
48
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
133,
144
]
} |
the dopac/da ratio is considered to be a measure of dopaminergic neuronal activity , thus suggesting a bilateral activation of the neostriatal dopaminergic afferents as a result of the motor performance . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
10,
12
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
143,
155
]
} |
these results indicate that the type of food ingested can influence dopaminergic responses to feeding , and argue against an exclusive role for motor or reward processes in determining da activity . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
68,
80
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
185,
187
]
} |
pre-session administration of doses of lithium chloride ( licl ) less than 3.0 meq/kg did not alter rates of responding whereas pairing either type of pellet with post-session injections of 1.8 meq/kg licl suppressed both lever pressing and consumption during subsequent sessions in which that pellet type was available ... | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
47,
55
]
} | {
"id": "C0065088",
"name": "licl",
"pos": [
201,
205
]
} |
the opiate antagonist naltrexone decreases glucose-stimulated insulin release , while the sensitivity of diabetic rats to naloxone-induced satiety is increased . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
22,
32
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
122,
130
]
} |
blood was drawn on the same days for estimation of norepinephrine , epinephrine , beta-endorphin , cortisol , and prolactin . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
51,
65
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
68,
79
]
} |
the action of crf can be potentiated by vasopressin , oxytocin , epinephrine , norepinephrine , vip , and angiotensin ii . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
65,
76
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
79,
93
]
} |
intracerebroventricular administration of crf in the rat produces prolonged elevations of plasma epinephrine , norepinephrine , glucose and glucagon ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
97,
108
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
111,
125
]
} |
the calcium antagonist dihydropyridine derivative nimodipine and its enantiomers bay n 5247 , bay n 5248 , as well as bay r 4407 ( calcium antagonist ( + ) -enantiomer of the calcium agonist dihydropyridine bay k 8644 ) do not exert antinociceptive effects in the rat as measured by the vocalization test in doses up to ... | NA | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
50,
60
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
191,
206
]
} |
younger children and white children were also shown to have significantly higher use rates than older children and black children . | NA | {
"id": "C1455726",
"name": "older",
"pos": [
96,
101
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
121,
129
]
} |
the effects on these of 25 mm concentrations of these monosaccharides , of alpha-methyl-glucoside and of the disaccharides sucrose , maltose , and lactose were measured . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
109,
122
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
123,
130
]
} |
the effects on these of 25 mm concentrations of these monosaccharides , of alpha-methyl-glucoside and of the disaccharides sucrose , maltose , and lactose were measured . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
109,
122
]
} | {
"id": "C0024658",
"name": "maltose",
"pos": [
133,
140
]
} |
cefotaxime , amikacin , cefuroxime and ceftazidime were the most effective drugs against enterobacter species , ps . aeruginosa , p. rettgeri and proteus mirabilis . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
0,
10
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
24,
34
]
} |
d-isomers of the branched-chain amino acids , i.e. , leucine , isoleucine and valine ( leu , ile , val ) are utilized relatively well by chicks but poorly by rats . | NA | {
"id": "C0002521",
"name": "branched-chain",
"pos": [
17,
31
]
} | {
"id": "C0023401",
"name": "leu",
"pos": [
87,
90
]
} |
d-isomers of the branched-chain amino acids , i.e. , leucine , isoleucine and valine ( leu , ile , val ) are utilized relatively well by chicks but poorly by rats . | NA | {
"id": "C0002521",
"name": "branched-chain",
"pos": [
17,
31
]
} | {
"id": "C0022192",
"name": "ile",
"pos": [
93,
96
]
} |
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