text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
d-isomers of the branched-chain amino acids , i.e. , leucine , isoleucine and valine ( leu , ile , val ) are utilized relatively well by chicks but poorly by rats . | NA | {
"id": "C0002521",
"name": "branched-chain",
"pos": [
17,
31
]
} | {
"id": "C0042285",
"name": "val",
"pos": [
99,
102
]
} |
prepregnancy body weight and gestational weight gain have an independent but cumulative influence on the birth weight . | NA | {
"id": "C0005910",
"name": "body weight",
"pos": [
13,
24
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
105,
117
]
} |
also the proportion of infants with birth-weight greater than 2500 g is higher in average ( 6.2 % ) and under-weight ( 4.4 % ) groups than in those over-weight ( 1.8 % ) . | NA | {
"id": "C0005612",
"name": "birth-weight",
"pos": [
36,
48
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
153,
159
]
} |
also the proportion of infants with birth-weight greater than 2500 g is higher in average ( 6.2 % ) and under-weight ( 4.4 % ) groups than in those over-weight ( 1.8 % ) . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
42,
48
]
} | {
"id": "C0497406",
"name": "over-weight",
"pos": [
148,
159
]
} |
lipoxygenase product formation by colonic epithelium as measured by hydroxyeicosatetraenoic acid ( hete ) and leukotriene b4 ( ltb4 ) production ( 5-hete greater than 12-hete greater than 15-hete greater than ltb4 ) accounted for 58 % of the total colonic production of these moieties , whereas epithelium accounted for ... | NA | {
"id": "C0044800",
"name": "12-hete",
"pos": [
167,
174
]
} | {
"id": "C0020349",
"name": "hete",
"pos": [
191,
195
]
} |
while phenylethanolamine n-methyltransferase ( pnmt ) immunoreactive cells largely corresponded to the intensely stained anp-like immunoreactive cells , suggesting that adrenaline cells contained a large amount of anp-like substance , noradrenaline cells contained a smaller amount of this substance than adrenaline cell... | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
235,
248
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
305,
315
]
} |
mr tomography is an important imaging method which is superior to sonography or ct in demonstrating complications resulting from the bleeding , such as effusions and haemarthroses . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
133,
141
]
} | {
"id": "C0018924",
"name": "haemarthroses",
"pos": [
166,
179
]
} |
the addition of phenobarbital ( pb ) to a sulphonylurea ( su ) regimen may improve glycemic control in patients with non- insulin dependent diabetes mellitus ( niddm , type ii ) . | NA | {
"id": "C0011849",
"name": "non",
"pos": [
117,
120
]
} | {
"id": "C0011860",
"name": "niddm",
"pos": [
160,
165
]
} |
pharmacological activities ( hypnotic , anticonvulsant and convulsant activities , acute toxicity and pentobarbital ( pb ) synergism ) of n-allyl , n'-methyl derivatives of barbiturates and related n-allyl substituted compounds were studied in mice . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
102,
115
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
173,
185
]
} |
indications for surgery have become rare since the availability of l-dopa , perhaps too rare for the slowly progressive forms with predominant tremor poorly relieved by dopa-therapy , surgery has a curative and probably preventive effect on the involuntary movements of limbs induced by this treatment . | NA | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
67,
73
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
169,
173
]
} |
[ difficult diagnosis of a rapidly developing post-traumatic tumor of the thymus region . encysted hematoma or intracystic hemorrhage ? ] . | NA | {
"id": "C0018944",
"name": "hematoma",
"pos": [
99,
107
]
} | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
123,
133
]
} |
pyroglobulins have been mainly found in patients with lymphoproliferative diseases ( especially waldenstrom 's macroglobulinemia , with or without cryoglobulinemia ) , systemic lupus erythematosus , and neoplasia . | NA | {
"id": "C0024314",
"name": "lymphoproliferative",
"pos": [
54,
73
]
} | {
"id": "C0024419",
"name": "waldenstrom 's macroglobulinemia",
"pos": [
96,
128
]
} |
an enzyme-linked immunosorbent assay ( elisa ) using wells coated with normal platelets has been tested in order to quantitate cell-bound immune complexes ( ics ) by measuring the uptake of alkaline phosphatase-conjugated antibodies to igg in the immune complexes . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
138,
154
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
222,
232
]
} |
among ctd , systemic lupus erythematosus ( sle ) , rheumatoid arthritis ( ra ) and sjogren 's syndrome are the diseases most frequently involved in the presence of cryoglobulins ( 8-48 % ) . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
51,
71
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
83,
102
]
} |
studies were made on the carcinogenic activity of butylated hydroxyanisole ( bha ) in rats , mice , and hamsters and the effect of the antioxidants bha , butylated hydroxytoluene ( bht ) , ethoxyquin ( eq ) , sodium l-ascorbate ( sa ) , ascorbic acid ( aa ) , sodium erythorbate ( se ) , propyl gallate ( pg ) , and alph... | NA | {
"id": "C0887557",
"name": "sodium",
"pos": [
209,
215
]
} | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
237,
250
]
} |
studies were made on the carcinogenic activity of butylated hydroxyanisole ( bha ) in rats , mice , and hamsters and the effect of the antioxidants bha , butylated hydroxytoluene ( bht ) , ethoxyquin ( eq ) , sodium l-ascorbate ( sa ) , ascorbic acid ( aa ) , sodium erythorbate ( se ) , propyl gallate ( pg ) , and alph... | NA | {
"id": "C0012200",
"name": "diethylnitrosamine",
"pos": [
475,
493
]
} | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
624,
635
]
} |
results obtained by others with fibroblasts and lymphocytes from individuals with the mediterranean variant of g6pdh deficiency also indicate that a reduction in the nadph cellular pool confers resistance to benzo ( a ) pyrene . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
32,
43
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
172,
180
]
} |
in the calculation of non-protein bound testosterone , the actual serum albumin concentration can be replaced by a fixed albumin concentration ( r=0.99 ; p less than 0.001 ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
26,
33
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
121,
128
]
} |
after 12 h of ischaemia the infarct size in the control group was fully comparable with that in the haemodiluted group : 28 +/- 3 and 27 +/- 4 ( percentage of the left ventricle , mean +/- sem ) , respectively . | NA | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
14,
23
]
} | {
"id": "C0021308",
"name": "infarct",
"pos": [
28,
35
]
} |
comparisons between ferritin , lactoferrin and c-reactive protein in the various groups supported the concept that ferritin behaves in part as an acute phase reactant and that hypoferraemia in inflammation is due to deviation of iron into ferritin stores . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
47,
65
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
146,
166
]
} |
it might , in some patients , be due to interaction of the igg with antibody or immune complex binding to platelets . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
68,
76
]
} | {
"id": "C0003313",
"name": "immune complex",
"pos": [
80,
94
]
} |
4 young thalassemic children ( 1-2 yr of age ) studied had high erythropoietic activity ranging from 661 to 5793 milliunits/ml -- significantly different from normal children of the same age . | NA | {
"id": "C0728836",
"name": "young",
"pos": [
2,
7
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
166,
174
]
} |
in healthy , haematologically normal subjects excretion of the test dose was greater following a hydroxocobalamin flushing dose than following a cyanocobalamin flushing dose , and to a lesser extent this was also true in patients requiring investigation . | NA | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
97,
113
]
} | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
145,
159
]
} |
there were occasional discrepant results , but in general it appears that , although reference values differ , hydroxocobalamin is a suitable replacement for cyanocobalamin in the schilling test . | NA | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
111,
127
]
} | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
158,
172
]
} |
it is concluded that pseudothrombocytopenia and various thrombocytopathies provide a significant confounding factor in the management of patients with alleged thrombocytopenia . | NA | {
"id": "C0005818",
"name": "thrombocytopathies",
"pos": [
56,
74
]
} | {
"id": "C0040034",
"name": "thrombocytopenia",
"pos": [
159,
175
]
} |
the binding of 125i-labelled anti-bovine serum albumin ( bsa ) -bsa immune complexes ( ic ) , giving a final molar antibody to antigen ratio of 1:1 , to monocytes isolated from 18 patients with systemic lupus erythematosus ( sle ) and from 10 normal healthy donors was quantitatively investigated . | NA | {
"id": "C0003313",
"name": "immune",
"pos": [
68,
74
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
115,
123
]
} |
between 1944 and 1947 the mortality statistics for the danish population show an epidemic increase of liver diseases : subacute necrosis and cirrhosis . | NA | {
"id": "C0023895",
"name": "of liver diseases",
"pos": [
99,
116
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
141,
150
]
} |
prolactinoma in women was diagnosed at a significantly younger age ( 34.3 years ) than in men ( 54.2 years ) or than non-secreting adenoma in both sexes ( 52.1 years ) . | NA | {
"id": "C0033375",
"name": "prolactinoma",
"pos": [
0,
12
]
} | {
"id": "C0001430",
"name": "adenoma",
"pos": [
131,
138
]
} |
isoelectric focusing of hb and hb chains showed the absence of hba , the presence of rapid bart 's and h hb and the presence of an alpha chain variant alpha q-thailand , alpha 74 asp -- -- his ( confirmation by fingerprinting of hb ) . | NA | {
"id": "C0019016",
"name": "hba",
"pos": [
63,
66
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
229,
231
]
} |
whereas a protracted inhibitory activity is observed in haemophiliacs after replacement therapy ( isoantibodies ) as well as in acquired haemophilia ( autoantibodies ) , immediate inhibition is characteristic of antibodies directed against phospholipids . | NA | {
"id": "C0022144",
"name": "isoantibodies",
"pos": [
98,
111
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
212,
222
]
} |
the t4 cell count using the full blood method is a precise test for evaluation of t4 cell elimination by hiv infection and the immune deficiency thus developing . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
105,
118
]
} | {
"id": "C0021051",
"name": "immune deficiency",
"pos": [
127,
144
]
} |
use of quick-freeze dsc on membranes of mixed lipid composition supports the existence of nonrandom distributions of lipids ( domains ) in fluid bilayers . | NA | {
"id": "C0025249",
"name": "membranes",
"pos": [
27,
36
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
117,
123
]
} |
the duration of postoperative functional starvation in malnourished patients without complications increased to an average of 22 days following a complication and was further prolonged after a complication . | NA | {
"id": "C0038187",
"name": "starvation",
"pos": [
41,
51
]
} | {
"id": "C0162429",
"name": "malnourished",
"pos": [
55,
67
]
} |
of 14 different antibiotics studied , we conclude that carbenicillin , mezlocillin , piperacillin , cefbuperazone and cefoxitin as single drugs and timentin ( ticarcillin with clavulanic acid ) and clindamycin with gentamicin and co-trimoxazole ( trimethoprium and sulfamethoxazole ) achieved therapeutic levels . | NA | {
"id": "C0041044",
"name": "co-trimoxazole",
"pos": [
230,
244
]
} | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
265,
281
]
} |
we conclude that preoperative serum ipth measurement is a very sensitive diagnostic test for primary hyperparathyroidism , but postoperative serum ipth measurement is not a good predictor for persistent or recurrent hyperparathyroidism . | NA | {
"id": "C0221002",
"name": "primary",
"pos": [
93,
100
]
} | {
"id": "C0020502",
"name": "hyperparathyroidism",
"pos": [
216,
235
]
} |
the neurological syndromes which play the key role in the clinical picture of the disease were distinguished . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
17,
26
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
82,
89
]
} |
the data indicate that the use of the panel of the simplest tests of immunological phenotyping provides in many cases sufficient information for differential diagnosis of reactive lymphadenopathies and malignant lymphoproliferative diseases as well as for diagnosing the early stage of lymphosarcoma leukemization . | NA | {
"id": "C0024314",
"name": "lymphoproliferative diseases",
"pos": [
212,
240
]
} | {
"id": "C0024299",
"name": "lymphosarcoma",
"pos": [
286,
299
]
} |
it was shown that leucocytes could compensate the manifestations of thrombocytopenia and thrombocytopathy in chronic myeloproliferative diseases . | NA | {
"id": "C0040034",
"name": "thrombocytopenia",
"pos": [
68,
84
]
} | {
"id": "C0005818",
"name": "thrombocytopathy",
"pos": [
89,
105
]
} |
lipid composition of platelet membranes and thromboxane a2 ( txa2 ) generation by platelets were investigated in eighty-seven anginal patients ( forty-two with resting angina in active phase and forty-five with effort stable angina or rest angina in inactive phase ) and in forty-five clinically healthy subjects of simi... | NA | {
"id": "C0002962",
"name": "angina",
"pos": [
126,
132
]
} | {
"id": "C0002965",
"name": "rest",
"pos": [
235,
239
]
} |
plasma lipids , content of cholesterol , total phospholipids ( and their saturated and unsaturated fatty acids ) and the different phospholipid fractions in platelet membrane were not different in the three groups . | NA | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
47,
60
]
} | {
"id": "C0771648",
"name": "phospholipid fractions",
"pos": [
131,
153
]
} |
the lungs were perfused with krebs henseleit buffer containing no protein ( khb ) , containing 1 g/100 ml bovine albumin ( khab ) or containing albumin together with 100 micrograms/ml soluble fibronectin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
66,
73
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
144,
151
]
} |
[ auranofin ( ridaura ) . a new peroral agent containing gold used in the treatment of rheumatoid arthritis ] . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
2,
11
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
57,
61
]
} |
genotoxicity and cytotoxicity of selected pyrrolizidine alkaloids , a possible alkenal metabolite of the alkaloids , and related alkenals . | NA | {
"id": "C0034335",
"name": "pyrrolizidine alkaloids",
"pos": [
42,
65
]
} | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
105,
114
]
} |
these observations show that in blood , cs2 binds ( in the form of al cs2 ) mainly to hemoglobin and to a small extent to other blood proteins . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
86,
96
]
} | {
"id": "C0005832",
"name": "blood proteins",
"pos": [
128,
142
]
} |
cadmium ( cd ) was administered as cdcl2 , cd-cys , cd-partial structural peptide of metallothionein ( mt ) ii , cd-mt i , and cd-mt ii to rats , and the distribution of and nephropathy caused by the corresponding cd compounds were examined . | NA | {
"id": "C0054412",
"name": "cdcl2",
"pos": [
35,
40
]
} | {
"id": "C0303174",
"name": "cd compounds",
"pos": [
214,
226
]
} |
no significant change in the ratio of liver weight to body weight was observed at 8 weeks ; | NA | {
"id": "C0005911",
"name": "change in",
"pos": [
15,
24
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
54,
65
]
} |
the high degree of correlation between i50 and the partition coefficients of the alcohols suggested that their interaction with membrane lipids is important for the inhibition of pah uptake , and also that pah ( but not tea ) transport is affected by alteration of the lipid environment of the membrane . | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
128,
143
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
269,
274
]
} |
congruent with these observations , much more n-acetyl-d-cysteine ( 47 % of dose ) was recovered unchanged in 24 hr urine than n-acetyl-l-cysteine ( 6.1 % of dose ) . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
57,
65
]
} | {
"id": "C0001047",
"name": "n-acetyl-l-cysteine",
"pos": [
127,
146
]
} |
it appears from these results that the 6-mp-induced muscle atrophy occurs only after treatment during the neonatal period and that the atrophy may be species-specific . | NA | {
"id": "C0026846",
"name": "muscle atrophy",
"pos": [
52,
66
]
} | {
"id": "C0333641",
"name": "atrophy",
"pos": [
135,
142
]
} |
the dose-response rat hepatic cytosolic receptor-binding avidities , aryl hydrocarbon hydroxylase ( ahh ) and ethoxyresorufin o-deethylase ( erod ) induction potencies in rat hepatoma h-4-ii e cells in culture were determined for 29 polynuclear aromatic hydrocarbons . | NA | {
"id": "C0003927",
"name": "aryl",
"pos": [
69,
73
]
} | {
"id": "C0059735",
"name": "ethoxyresorufin o-deethylase",
"pos": [
110,
138
]
} |
although most effective suppression of the humoral anti-dnp response was seen in animals receiving their single dose of suppressive antibody 2 weeks before first exposure to antigen , suppression of the igg response was evident at all intervals examined up to 232 days in mice given monoclonal antibody between 0.1 day a... | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
132,
140
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
283,
302
]
} |
these results are consistent with previous studies suggesting that the in vivo elaboration of lymphokines during allogeneic cellular interactions leads to an increase in cr , rbf , and vp . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
113,
123
]
} | {
"id": "C0007634",
"name": "cr",
"pos": [
170,
172
]
} |
the biochemical nature of the reactive epitopes was investigated by determining the binding ability of the mcabs to protease- or glycosidase-treated antigen preparations . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
39,
47
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
149,
156
]
} |
one of the three monomorphic mcabs recognized a protein-defined epitope , while the other two antibodies detected epitopes in which carbohydrates were involved . | NA | {
"id": "C0003250",
"name": "mcabs",
"pos": [
29,
34
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
94,
104
]
} |
the value of cystometry in the diagnosis of recurrent urinary incontinence is to differentiate between urge and stress incontinence . | NA | {
"id": "C0042024",
"name": "urinary incontinence",
"pos": [
54,
74
]
} | {
"id": "C0042025",
"name": "stress incontinence",
"pos": [
112,
131
]
} |
urine and bladder washouts were taken from 77 patients with histologically proven bladder tumors , 152 patients after resection of the tumor and 100 patients without tumor of the urinary tract . | NA | {
"id": "C0005695",
"name": "bladder",
"pos": [
10,
17
]
} | {
"id": "C0042076",
"name": "tumor",
"pos": [
166,
171
]
} |
there was significant alteration of the acinar cells with disruption of the cells from the basement membrane , as well as vacuolization and change in fibroblast shape and density . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
47,
52
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
150,
160
]
} |
no difference was observed in the antibody titres of animals treated twice with 5 mg selenium as sodium selenate . | NA | {
"id": "C0036581",
"name": "selenium",
"pos": [
85,
93
]
} | {
"id": "C0074765",
"name": "sodium selenate",
"pos": [
97,
112
]
} |
it was found that the replication of the virus in chick embryo fibroblasts was inhibited when the cells were treated with 1 mm theophylline . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
63,
74
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
98,
103
]
} |
the replacement of sinusoidal cells from bone-marrow was greatly accelerated after liver damage had been induced by sublethal doses of endotoxin ( lps ) , and proliferation was also enhanced after treatment with lps . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
135,
144
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
212,
215
]
} |
it is postulated that the gfap immunostaining within neoplastic cells of mullerian origin may be a reflection of the phenotypic diversity of intermediate filament proteins that can be expressed by malignant neoplastic cells , that the polypeptides of gfap may be heterogeneous , that there may be an ontogenic relationsh... | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
141,
171
]
} | {
"id": "C0017626",
"name": "gfap",
"pos": [
251,
255
]
} |
during the first few weeks of infection , dna from the bone marrow contained as many as 0.5 copies of viral dna per haploid genome . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
42,
45
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
102,
111
]
} |
in contrast , neither splenic nor thymic dna contained significant levels of viral dna sequences even though infected birds developed titers of circulating virus between 10 ( 5 ) and 10 ( 6 ) iu/ml of plasma . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
41,
44
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
77,
86
]
} |
[ possibility of using tumor markers , pituitary gonadotropic hormones and prolactin in the diagnosis of breast cancer ] . | NA | {
"id": "C0018066",
"name": "pituitary gonadotropic hormones",
"pos": [
39,
70
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
75,
84
]
} |
[ mallory-weiss syndrome in a patient with a heart defect of the tetralogy of fallot type ] . | NA | {
"id": "C0018798",
"name": "heart defect",
"pos": [
45,
57
]
} | {
"id": "C0039685",
"name": "of",
"pos": [
75,
77
]
} |
four patients are presented aged over 65 years in whom a state of cardiogenic shock was present due to myocardial infarction of the following localization : anterior in two and posterior in two . | NA | {
"id": "C0036980",
"name": "cardiogenic",
"pos": [
66,
77
]
} | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
103,
124
]
} |
discussing the findings , observations and literature , the difference between psoriatic enteropathy , malabsorption in systemic amyloidosis and pseudomembranous enteritis in amyloidosis is shown . | NA | {
"id": "C0021831",
"name": "enteropathy",
"pos": [
89,
100
]
} | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
103,
116
]
} |
thus , prevention of acute myocardial infarction would have been possible only in about half of the patients with impending myocardial infarction due to the short duration of preceding angina . | NA | {
"id": "C0002965",
"name": "impending",
"pos": [
114,
123
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
185,
191
]
} |
the types of arrhythmia induced on day 24 were sustained ventricular tachycardia with a mean cycle length of 207 ms in 6 cases ( 5 monomorphic , 1 polymorphic ) , and ventricular fibrillation in 3 cases . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
13,
23
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
167,
191
]
} |
distant ischemia was distinguished from peri-infarctional ischemia by the presence of transient thallium defects in , or slow thallium washout from myocardium not supplied by the infarct-related coronary artery . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
8,
16
]
} | {
"id": "C0021308",
"name": "infarct",
"pos": [
179,
186
]
} |
the occurrence of distant ischemia was found to be dependent on the severity of stenosis in non-infarct coronary vessels . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
26,
34
]
} | {
"id": "C0021308",
"name": "infarct",
"pos": [
96,
103
]
} |
12 ( 86 % ) of 14 patients with non-infarct stenosis of 75 % or greater had distant ischemia , but only 1 ( 4 % ) of 27 patients with a stenosis of less than 75 % in another vessel . | NA | {
"id": "C0021308",
"name": "infarct",
"pos": [
36,
43
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
84,
92
]
} |
in the presence of distant ischemia , peri-infarctional ischemia was in 11 patients ( 85 % ) associated with collaterals supplying the infarct zone , whereas in 13 ( 87 % ) of the patients with peri-infarctional ischemia only , incomplete obstruction of the infarct-vessel was observed . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
27,
35
]
} | {
"id": "C0021308",
"name": "infarct",
"pos": [
258,
265
]
} |
it is concluded that , by the distinction between peri-infarctional and distant ischemia , the presence of a significant stenosis in non-infarct vessels can be non-invasively predicted from tomographic thallium scintigraphy with dipyridamole . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
80,
88
]
} | {
"id": "C0021308",
"name": "infarct",
"pos": [
137,
144
]
} |
the intratumorous distribution of catecholaminergic tumour cells and s100 protein-positive elements of 8 neuroblastomas , 8 ganglioneuroblastomas and 2 ganglioneuromas were studied using catecholamine fluorescence and immunohistochemical staining , respectively . | NA | {
"id": "C0027819",
"name": "neuroblastomas",
"pos": [
105,
119
]
} | {
"id": "C0206718",
"name": "ganglioneuroblastomas",
"pos": [
124,
145
]
} |
the report indicates that any evidence of a tumour disease apart from the cysts must bei excluded . | NA | {
"id": "C0027651",
"name": "tumour",
"pos": [
44,
50
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
74,
79
]
} |
for both astrocytomas and glioblastomas there is a tendency for a decrease in the expression of gfap to be associated with a shorter preoperative history and with a shorter survival time . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
9,
21
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
26,
39
]
} |
whereas leukoplakias ( with or without dysplasia ) showed an homogeneous growth pattern , carcinomas and basaliomas demonstrated significantly higher proliferative activity in the tumor periphery . | NA | {
"id": "C0007097",
"name": "carcinomas",
"pos": [
90,
100
]
} | {
"id": "C0007117",
"name": "basaliomas",
"pos": [
105,
115
]
} |
mycobactins and exochelins from mycobacteria formed complexes with many heavy metals in the absence of iron . | NA | {
"id": "C0347988",
"name": "heavy",
"pos": [
72,
77
]
} | {
"id": "C0302583",
"name": "iron",
"pos": [
103,
107
]
} |
the enzyme inactivated not only penicillin derivatives ( including ureidopenicillins ) , but also first-generation cephalosporins and above all oxime-cephalosporins such as cefuroxime , cefotaxime and related derivatives . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
173,
183
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
186,
196
]
} |
moreover , it showed also a gradual transition in dna values from 1c to 2c , and very few nuclei with polyploid dna values . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
21,
22
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
112,
115
]
} |
this inhibition was caused by the binding of the allergen with anti-a-antibodies , which was indicative of the antigenic similarity between staphylococcus and group-specific factor a . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
49,
57
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
111,
120
]
} |
[ assessment of the specific activity of commercial allergen preparations made of house dust in the bacteriosorption reaction : a comparison with the results of the radioallergosorbent inhibition test ] . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
52,
60
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
82,
92
]
} |
this antiserum inhibited rast by 76 % and , therefore , contained antibodies to most of the allergenic determinants of hd . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
5,
14
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
66,
76
]
} |
the dopa oxidase activity of tyrosinase in the skin from albino and black mice was assayed using a technique based on the formation of two diastereomers of 5-s-cysteinyldopa when incubating tissue extracts with both l-dopa and d-dopa as substrates in the presence of cysteine . | NA | {
"id": "C0010665",
"name": "cysteinyldopa",
"pos": [
160,
173
]
} | {
"id": "C0010654",
"name": "cysteine",
"pos": [
267,
275
]
} |
the dopa oxidase activity of tyrosinase in the skin from albino and black mice was assayed using a technique based on the formation of two diastereomers of 5-s-cysteinyldopa when incubating tissue extracts with both l-dopa and d-dopa as substrates in the presence of cysteine . | NA | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
216,
222
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
229,
233
]
} |
this stereospecific dopa-oxidation is indicative of the presence of tyrosinase and corresponds well with earlier determinations of the rates of oxidation for human tyrosinase , using l-dopa and d-dopa as substrates . | NA | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
183,
189
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
196,
200
]
} |
only mild symptoms of retinoid intoxication -- headache , hallucinations and vertebral pain -- were observed after ingestion of 800 mg isotretinoin among other drugs . | NA | {
"id": "C0035339",
"name": "retinoid",
"pos": [
22,
30
]
} | {
"id": "C0022265",
"name": "isotretinoin",
"pos": [
135,
147
]
} |
only mild symptoms of retinoid intoxication -- headache , hallucinations and vertebral pain -- were observed after ingestion of 800 mg isotretinoin among other drugs . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
47,
55
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
87,
91
]
} |
after 8 weeks of this regimen , gnrh-a , buserelin ( d-ser-tbu-ea-lhrh ) , 200 micrograms per day sc , was added and given for 8 weeks . | NA | {
"id": "C0006456",
"name": "buserelin",
"pos": [
41,
50
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
66,
70
]
} |
this case unequivocally documents autonomous dysfunction of the adrenal cortex in this rare form of cushing 's syndrome and the efficacy of ketoconazole in the treatment of acth-independent hypercortisolism . | NA | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
100,
119
]
} | {
"id": "C0001622",
"name": "hypercortisolism",
"pos": [
190,
206
]
} |
met-enk , however , was not secreted in proportion to either epinephrine ( e ) , norepinephrine ( ne ) or total cas ( e + ne ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
61,
72
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
122,
124
]
} |
in two patients who were normotensive , nifedipine prevented a rise in blood pressure but not in plasma epinephrine and norepinephrine following the iv injection of the dopamine-antagonist metoclopramide . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
104,
115
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
120,
134
]
} |
activated t cells were assayed by monoclonal antibodies against early ( 4f2 ) and late activation surface lymphocyte antigens ( different epitopes of class ii antigens ) . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
117,
125
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
138,
146
]
} |
metabolism of [ 3h ] testosterone and [ 3h ] epitestosterone was measured under standardized conditions in 1-4 growing ( anagen ) hair roots . | NA | {
"id": "C0039601",
"name": "testosterone",
"pos": [
21,
33
]
} | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
45,
60
]
} |
when the mean values of the 5 alpha-reduced metabolites from testosterone ( androstanedione and dihydrotestosterone ) or from epitestosterone ( epidihydrotesterone ) were compared in both groups , similar values were observed . | NA | {
"id": "C0039601",
"name": "testosterone",
"pos": [
61,
73
]
} | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
126,
141
]
} |
clinical findings were : height 183 cm , weight 62 kg , increased length of lower limbs , p2-a2 pilosity and micropenis . | NA | {
"id": "C0037088",
"name": "clinical findings",
"pos": [
0,
17
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
41,
47
]
} |
[ the pathophysiology of malignant lymphoma from the hematological point of view . 3. changes in peripheral blood lymphocyte count and the recovery of cell-mediated immune function after therapy of t- , b-malignant lymphomas and hodgkin 's disease ] . | NA | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
205,
224
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
229,
247
]
} |
the zone thickness , the chondrocyte number in a certain area and in the cell columns as well , and the volume density of the chondrocytes were determined . | NA | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
25,
36
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
73,
77
]
} |
the relationship between the number of amine groups and ototoxicity was studied using spermine , spermidine and 1,3-diaminopropane , which are polyamines with differing numbers of amine groups . | NA | {
"id": "C0032433",
"name": "polyamines",
"pos": [
143,
153
]
} | {
"id": "C0002508",
"name": "amine",
"pos": [
180,
185
]
} |
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