text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in electron microscopy , the constituent cells combined ultrastructural characteristics of both fibroblasts and smooth muscle cells. , immunoperoxidase method showed that anti-smooth muscle antibodies binded to the cytoplasm of the bundle forming cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
41,
46
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
96,
107
]
} |
results with purified mumps virus proteins demonstrated that the antigen-antibody reactions that partake in the c.a.-elisa are mainly associated with the nucleoprotein antigen . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
34,
42
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
154,
167
]
} |
a review of the current literature concerning development of nitrate tolerance in the treatment of angina pectoris suggests that : development of nitrate tolerance is a clinical reality development of tolerance do not seem to differ for nitroglycerin , isosorbide-dinitrate or isosorbide-5-mononitrate a high nitrate dos... | NA | {
"id": "C0022252",
"name": "isosorbide-dinitrate",
"pos": [
253,
273
]
} | {
"id": "C0064079",
"name": "isosorbide-5-mononitrate",
"pos": [
277,
301
]
} |
this suggests the presence of a negative capillary charge barrier restricting anionic solutes , which also could be experimentally verified ( study i & ii ) , but the importance of this barrier is not yet fully clear . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
78,
85
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
194,
195
]
} |
upiiip was found to be significantly elevated in acute hepatitis , chronic hepatitis , liver cirrhosis , hepatocellular carcinoma and other liver diseases , in which the elevation of spiiip has been reported by others . | NA | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
87,
102
]
} | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
140,
154
]
} |
substance p , a neuropeptide of the tachykinin group , inhibits measles virus replication in cell culture and partially blocks viral fusion activity assayed in the haemolysis system . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
0,
11
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
36,
46
]
} |
in 30 patients with atopic dermatitis and 40 with allergic contact dermatitis in the chronic stage intracutaneous tests were performed with 0.1 ml histamine 1:10,000 in affected and non-affected skin . | NA | {
"id": "C0011615",
"name": "atopic dermatitis",
"pos": [
20,
37
]
} | {
"id": "C0011603",
"name": "dermatitis",
"pos": [
67,
77
]
} |
several variables were significantly ( p less than 0.05 ) more common in the vt group : age older than 60 years , previous ami , history of angina pectoris , occurrence of vt or ventricular fibrillation in the coronary care unit , left ventricular ejection fraction less than 30 % , rales greater than bibasilar in the c... | NA | {
"id": "C0039231",
"name": "vt",
"pos": [
77,
79
]
} | {
"id": "C0042514",
"name": "vt",
"pos": [
172,
174
]
} |
three radionuclide angiographic patterns were recognized in patients with non-q infarction : no wall motion abnormalities ( n = 8 ) , single-segment wall motion abnormalities ( n = 10 ) and multiple-segment wall motion abnormalities ( n = 9 ) . | NA | {
"id": "C0000768",
"name": "abnormalities",
"pos": [
108,
121
]
} | {
"id": "C0000772",
"name": "multiple",
"pos": [
190,
198
]
} |
cardiac arrest occurred without symptoms in 38 % of the patients with sudden cardiac arrest and was the first expression of coronary artery disease in 4 % of the entire study group . | NA | {
"id": "C0018790",
"name": "cardiac arrest",
"pos": [
0,
14
]
} | {
"id": "C0018799",
"name": "the",
"pos": [
158,
161
]
} |
systemic and coronary hemodynamic effects of the new dihydropyridine calcium antagonist nisoldipine were studied over a 30-minute period in 12 patients with angina pectoris . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium",
"pos": [
53,
76
]
} | {
"id": "C0028116",
"name": "nisoldipine",
"pos": [
88,
99
]
} |
new 2-site labeled monoclonal antibody techniques were used to measure serially plasma levels of brain-type creatine kinase ( ck-bb ) , heart-type creatine kinase ( ck-mb ) and muscle-type creatine kinase ( ck-mm ) during a 20-hour postoperative period in 24 infants after deep hypothermia and total circulatory arrest u... | NA | {
"id": "C0010289",
"name": "ck-bb",
"pos": [
126,
131
]
} | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
189,
204
]
} |
new 2-site labeled monoclonal antibody techniques were used to measure serially plasma levels of brain-type creatine kinase ( ck-bb ) , heart-type creatine kinase ( ck-mb ) and muscle-type creatine kinase ( ck-mm ) during a 20-hour postoperative period in 24 infants after deep hypothermia and total circulatory arrest u... | NA | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
108,
123
]
} | {
"id": "C0010291",
"name": "ck-mm",
"pos": [
207,
212
]
} |
bmis that are independent of stature and still highly correlated to weight ( r = 0.89-0.98 ) over all ages and distributions of fatness and leanness are w/s2 in men and both w/s and w/s1.5 in women . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
68,
74
]
} | {
"id": "C0039870",
"name": "leanness",
"pos": [
140,
148
]
} |
effects of isocaloric changes in dietary fat on plasma lipoproteins and lipids and enzymes of erythrocytes and leucocytes were assessed . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
55,
67
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
72,
78
]
} |
stimulated by the suggestion that water fluoride greater than 1 mg/l may protect against osteoporosis , we studied bone mass of women in three rural communities with differing mineral content of the water supply . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
34,
39
]
} | {
"id": "C0026157",
"name": "mineral",
"pos": [
176,
183
]
} |
oral administration of vitamin e ( 100 mg tocopherol x kg-1 x day-1 ) as tocopheryl polyethylene glycol 1000 succinate ( tpgs ) to a child with congenital hepatic cholestasis ( unresponsive to oral administration of dl-alpha-tocopheryl acetate ) promoted an increase of tocopherol in plasma and adipose tissue while toco... | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
23,
32
]
} | {
"id": "C0078373",
"name": "tocopheryl acetate",
"pos": [
598,
616
]
} |
oral administration of vitamin e ( 100 mg tocopherol x kg-1 x day-1 ) as tocopheryl polyethylene glycol 1000 succinate ( tpgs ) to a child with congenital hepatic cholestasis ( unresponsive to oral administration of dl-alpha-tocopheryl acetate ) promoted an increase of tocopherol in plasma and adipose tissue while toco... | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
23,
32
]
} | {
"id": "C0994472",
"name": "dl-alpha-tocopheryl acetate",
"pos": [
589,
616
]
} |
among these were 64 ( 24 % ) mucoepidermoid tumors ( all degrees of differentiation ) , 50 ( 18 % ) adenocarcinomas , 40 ( 15 % ) malignant mixed tumors , 39 ( 14 % ) adenoid cystic carcinomas , 37 ( 14 % ) undifferentiated , 21 ( 8 % ) acinic , and 20 ( 7 % ) squamous cell carcinomas . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
100,
115
]
} | {
"id": "C0010606",
"name": "adenoid cystic carcinomas",
"pos": [
167,
192
]
} |
a variety of monoclonal anti-iga-subclass reagents were applied , which proved to be specific in control experiments on blastoid cells generated by pokeweed mitogen stimulation of blood mononuclear cells and frozen tissue sections of normal jejunum . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
129,
134
]
} | {
"id": "C1321301",
"name": "blood mononuclear",
"pos": [
180,
197
]
} |
this theory was the basis for the treatment of three patients with abnormal condyles , one suffering from hemifacial microsomia , one patient with a unilateral condylar fracture followed by displacement and secondary resorption of the condyle , and one patient with bilateral loss of condylar cartilage as a result of tr... | NA | {
"id": "C0016658",
"name": "fracture",
"pos": [
169,
177
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
318,
324
]
} |
a case of small intestinal obstruction in an 82-yr-old woman caused by an ileoileal intussusception is reported . | NA | {
"id": "C0021843",
"name": "of",
"pos": [
7,
9
]
} | {
"id": "C0021933",
"name": "intussusception",
"pos": [
84,
99
]
} |
cocultivation of the patient 's fibroblasts with either an immortal chinese hamster cell line or with a human male fibroblast strain carrying a t ( 4 ; 6 ) ( p14 ; q21 ) translocation showed that the phenomenon was not corrected or induced by a diffusible factor or by cell-to-cell contact . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
32,
42
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
277,
281
]
} |
plasma cholinesterase was estimated to have been inhibited by an average of 15.6 % ( p less than 0.01 ) , and rbc cholinesterase by 5.6 % ( p less than 0.01 ) . | NA | {
"id": "C0008429",
"name": "plasma cholinesterase",
"pos": [
0,
21
]
} | {
"id": "C0001044",
"name": "rbc cholinesterase",
"pos": [
110,
128
]
} |
protection against exercise-induced asthma with this drug has been variable , but ipratropium has been found particularly useful in psychogenic asthma . | NA | {
"id": "C0004099",
"name": "exercise-induced asthma",
"pos": [
19,
42
]
} | {
"id": "C0004096",
"name": "asthma",
"pos": [
144,
150
]
} |
more recently , other neuropeptides ( substance p , neurokinin a , and calcitonin gene-related peptide ) have been localized in nerves in airways . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
22,
35
]
} | {
"id": "C0006669",
"name": "calcitonin gene-related peptide",
"pos": [
71,
102
]
} |
to further investigate the relationship between piroxicam and gastrointestinal bleeding , a 14-month prospective case study was undertaken of all patients hospitalized in tromso , norway , for hematemesis , melena , or perforation . | NA | {
"id": "C0017181",
"name": "gastrointestinal",
"pos": [
62,
78
]
} | {
"id": "C0018926",
"name": "hematemesis",
"pos": [
193,
204
]
} |
to further investigate the relationship between piroxicam and gastrointestinal bleeding , a 14-month prospective case study was undertaken of all patients hospitalized in tromso , norway , for hematemesis , melena , or perforation . | NA | {
"id": "C0017181",
"name": "gastrointestinal",
"pos": [
62,
78
]
} | {
"id": "C0025222",
"name": "melena",
"pos": [
207,
213
]
} |
eight patients ( 4 males , 4 females ) were affected with a previously undefined multiple congenital anomalies/mental retardation syndrome which was designated the cardio-facio-cutaneous ( cfc ) syndrome and which includes congenital heart defects , characteristic facial appearance , ectodermal abnormalities , and grow... | NA | {
"id": "C0000772",
"name": "multiple congenital anomalies",
"pos": [
81,
110
]
} | {
"id": "C0000768",
"name": "abnormalities",
"pos": [
296,
309
]
} |
six glycogen storage diseases ( resulting from deficiencies of acid maltase , phosphorylase , phosphofructokinase , phosphoglycerate kinase , phosphoglycerate mutase , and lactate dehydrogenase ) and one mitochondrial myopathy ( cytochrome c oxidase deficiency ) are reviewed to illustrate : clinical heterogeneity , bio... | NA | {
"id": "C0017919",
"name": "glycogen storage diseases",
"pos": [
4,
29
]
} | {
"id": "C0017921",
"name": "deficiencies of acid maltase",
"pos": [
47,
75
]
} |
a plan of an investigation combining dna and conventional techniques is outlined that is suitable for centers not actively engaged in molecular genetics research , based on the detection of molecular deletions , the most efficient use of multiple dna polymorphisms , and the integration of this data with creatine kinase... | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
247,
250
]
} |
steroid receptor concentrations correlated negatively with the duration of clomiphene citrate therapy , which implies a time-dependent suppressive effect of clomiphene citrate on measurable cytosolic estradiol and progesterone receptor concentrations during the luteal phase of the cycle . | NA | {
"id": "C0034840",
"name": "steroid receptor",
"pos": [
0,
16
]
} | {
"id": "C0034833",
"name": "progesterone receptor",
"pos": [
214,
235
]
} |
a significant reduction of the ratios of the steroidal pairs 17 alpha-hydroxyprogesterone-progesterone ( 17 alpha-hydroxylase ) and androstenedione-17 alpha-hydroxyprogesterone ( 17,20-desmolase ) was observed after human chorionic gonadotropin injection ( p less than 0.001 ) . | NA | {
"id": "C0020387",
"name": "alpha-hydroxyprogesterone",
"pos": [
64,
89
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
164,
176
]
} |
we examined the effect of an isolated fraction of follicular fluid , termed follicle regulatory protein , on the production of estrogen , progesterone , and 20 alpha-dihydroprogesterone by cultured rat ovarian granulosa cells . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
138,
150
]
} | {
"id": "C0012311",
"name": "20",
"pos": [
157,
159
]
} |
we examined whether cholesterol substrate in the form of high-density lipoprotein or low-density lipoprotein could overcome the follicle regulatory protein inhibition of progesterone and 20 alpha-dihydroprogesterone production stimulated by follicle-stimulating hormone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
170,
182
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
187,
215
]
} |
increases in cholesterol-esterifying activity uniformly exceeded increases in cholesteryl ester hydrolytic activity in congruence with net accumulation of cholesteryl ester . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
13,
24
]
} | {
"id": "C0008387",
"name": "cholesteryl",
"pos": [
155,
166
]
} |
the uptake of 3-o-methyl-d- [ u-14c ] glucose was not affected by a prior loading of the cells with the unlabeled hexose and its release from prelabeled cells was observed in the absence of any concentration gradient across the plasma membrane . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
38,
45
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
114,
120
]
} |
when d-glucose was measured by an enzymic procedure in cells incubated for 30 min at 37 degrees c in the presence of 50.0 mm d-glucose , the apparent distribution space of the hexose remained lower than the intracellular water space . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
7,
14
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
176,
182
]
} |
thus attempts were made to characterize voltage-activated inward and outward membrane currents and to examine to what extent these were affected by both long-term and acute exposure to the phorbol ester 12-o-tetradecanoylphorbol-13-acetate ( tpa ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
189,
202
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
203,
239
]
} |
however , certain proglumide derivatives had a much higher affinity for the pancreatic cck receptor than for the cck receptor mediating gallbladder contraction . | NA | {
"id": "C0250571",
"name": "a",
"pos": [
14,
15
]
} | {
"id": "C0034791",
"name": "cck receptor",
"pos": [
113,
125
]
} |
the contribution of amino acids other than glutamine to renal ammoniagenesis was investigated in renal tubules obtained from control rats and rats with metabolic acidosis by incubating 2.5 mm [ 5-15n ] glutamine , [ 2-15n ] glutamine , [ 15n ] glutamate , [ 15n ] aspartate , [ 15n ] alanine , or [ 15n ] glycine , eithe... | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
284,
291
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
443,
454
]
} |
the contribution of amino acids other than glutamine to renal ammoniagenesis was investigated in renal tubules obtained from control rats and rats with metabolic acidosis by incubating 2.5 mm [ 5-15n ] glutamine , [ 2-15n ] glutamine , [ 15n ] glutamate , [ 15n ] aspartate , [ 15n ] alanine , or [ 15n ] glycine , eithe... | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
305,
312
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
443,
454
]
} |
to test the hypothesis that acute oali produces a significant injury to the heart , the lv mechanics of pentobarbital-anesthetized dogs with ( n = 6 ) and without ( n = 6 ) oali were evaluated . | NA | {
"id": "C0242488",
"name": "acute oali",
"pos": [
28,
38
]
} | {
"id": "C0273115",
"name": "oali",
"pos": [
173,
177
]
} |
other experiments demonstrated that ach elicited a prompt elevation of circulating norepinephrine and epinephrine in these turtles and led to the hypothesis that the renin response to ach was secondary to the release of endogenous catecholamines . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
83,
97
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
102,
113
]
} |
taken as a whole , these data suggest that in this primitive species renin activity is elevated by endogenous catecholamines even though isoproterenol , a classical beta-adrenergic agonist , is without effect . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
110,
124
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
137,
150
]
} |
by use of isotopic balance models , the fraction of water lost via fractionating routes was estimated from the isotopic abundances of body water , local drinking water , and dietary solids . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
52,
57
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
153,
167
]
} |
although pentobarbital effectively reduces environmental influences , barbiturates affect hemodynamic and hormonal responses and preclude normal daily feeding and activity patterns . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
9,
22
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
70,
82
]
} |
for the hangover condition , they flew 14 hours after drinking enough ethanol mixed with diet soft drinks to attain a blood alcohol concentration of 100 mg/dl . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
70,
77
]
} | {
"id": "C0684262",
"name": "blood alcohol concentration",
"pos": [
118,
145
]
} |
the purified component , denoted antigen 19/20 iia , seemed to be representative for the allergenic activity of the major allergen . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
33,
40
]
} | {
"id": "C0002092",
"name": "allergenic",
"pos": [
89,
99
]
} |
species-specific enzyme-linked immunosorbent assays ( elisa ) for major excrement allergens ( dp42 , df6 and dm6 ) of d. pteronyssinus , d. farinae and d. microceras in house dust were established , using immunoabsorbed , monospecific rabbit antibodies , coupled to horse radish peroxidase . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
82,
91
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
169,
179
]
} |
the ability of azelastine and selected antiallergic drugs to inhibit srs-a ( leukotriene ) -mediated acute lung anaphylaxis in guinea pigs ( konzett-rossler method ) was investigated . | NA | {
"id": "C0038091",
"name": "srs-a",
"pos": [
69,
74
]
} | {
"id": "C0023545",
"name": "leukotriene",
"pos": [
77,
88
]
} |
the induction characteristics of thiopentone , etomidate and methohexitone have been compared to those of propofol ( 2,6 di-isopropyl phenol ) in unpremedicated patients . | NA | {
"id": "C0033487",
"name": "propofol",
"pos": [
106,
114
]
} | {
"id": "C0031428",
"name": "phenol",
"pos": [
134,
140
]
} |
study entry criteria were : hypodynamic septic shock ( mean arterial pressure less than 50 mmhg and cardiac index less than 3.5 l/min ) despite a highly positive fluid balance ( greater than +2,000 ml during the last 12 h ) and use of catecholamines ( greater than 15 mcg/kg/min dobutamine ) . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
235,
249
]
} | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
279,
289
]
} |
thus , the data indicate that in cyst epithelium keratin filaments are highly organized and may confer the structural strength necessary for cells lining cyst lumina . | NA | {
"id": "C0014511",
"name": "cyst epithelium",
"pos": [
33,
48
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
154,
158
]
} |
felodipine is a new dihydropyridine calcium antagonist , and in hypertension it is a much more effective `` '' third-line '' '' drug than hydralazine . | NA | {
"id": "C0015772",
"name": "felodipine",
"pos": [
0,
10
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonist",
"pos": [
20,
54
]
} |
nifedipine , on the other hand , is the established dihydropyridine calcium antagonist that has been increasingly used to treat hypertension . | NA | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
0,
10
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonist",
"pos": [
52,
86
]
} |
although more long-term , follow-up studies supporting our results are needed , we suggest that a post-adenotonsillectomy drop in immunoglobulin and siga levels may predispose children to a constellation of disorders . | NA | {
"id": "C0020835",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0020838",
"name": "siga",
"pos": [
149,
153
]
} |
a preliminary study ( n = 13 samples ) showed that analysis of total fatty acids ( tfa ) and of phospholipids ( pl ) was more discriminatory than analysis of free fatty acids ( ffa ) , triglycerides ( tg ) or esterified cholesterol ( ec ) . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
69,
80
]
} | {
"id": "C0015688",
"name": "free",
"pos": [
158,
162
]
} |
a dna-hybridization dot-blot technique was developed to detect the presence of pseudorabies virus ( prv ) dna in porcine tissue . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
0,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
106,
109
]
} |
five groups of 12 sheep each were given gentamicin im : group i , 2 mg of gentamicin sulfate/kg once ; | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
40,
50
]
} | {
"id": "C0546866",
"name": "gentamicin sulfate",
"pos": [
74,
92
]
} |
the endotoxin inoculation comprised 10 micrograms of escherichia coli o26 : b6 lipopolysaccharide injected into one of the rear quarters ( mammae ) . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
4,
13
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
79,
97
]
} |
at 10 days , lungs from bleomycin-treated rats showed multifocal interstitial and intraalveolar fibrosis , a nearly 2-fold increase in total lung hydroxyproline , and a 3-fold increase in the incorporation of [ 3h ] proline into bacterial collagenase-sensitive protein . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
146,
160
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
216,
223
]
} |
in speculating about mechanisms that might give rise to t-cell epitopes appearing within different hla-dr frameworks , we return to the hypothesis expressed above that suggests that gene-conversion-like events might be involved in shuffling the hypervariable segments of hla-d region exons into alternative hla-d region ... | NA | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
99,
105
]
} | {
"id": "C0019754",
"name": "hla-d",
"pos": [
307,
312
]
} |
in normotensive pregnancy urinary kallikrein excretion remained unchanged during the late third trimester until delivery ( 12.6 +/- 1.7 ncat in 24 hours in preterm , 10.8 +/- 1.2 before delivery ) . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
16,
25
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
90,
105
]
} |
in contrast to the reports of other workers who have studied the fatty-acid composition of platelet membranes after feeding various fish oil supplements , in the rat heart the major effect of tuna fish oil is an increase in the proportion of dha rather than epa in the cardiac phospholipids . | NA | {
"id": "C0016157",
"name": "fish oil",
"pos": [
132,
140
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
202,
205
]
} |
when grown to high density in a serum-poor medium , these cells differentiated further into typical multinucleated myotubes that expressed the m isoform of creatine kinase and increased levels of surface antigen 5.1h11 , creatine kinase , and nicotinic acetylcholine receptors , but no detectable thy 1 antigen . | NA | {
"id": "C0010291",
"name": "m",
"pos": [
36,
37
]
} | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
221,
236
]
} |
mri scans demonstrated multiple lesions in 21 patients whereas ep studies showed multiple abnormalities in 14 patients ( 4 of whom had only somatosensory ep abnormalities ) . | NA | {
"id": "C0000772",
"name": "multiple abnormalities",
"pos": [
81,
103
]
} | {
"id": "C0000768",
"name": "abnormalities",
"pos": [
157,
170
]
} |
it was shown that by the level of the mutagenic effect the antibiotics might be arranged as follows with respect to the decrease in their activity : carminomycin -- -- doxorubicin -- -- daunomycin . | NA | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
149,
161
]
} | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
186,
196
]
} |
it was shown that by the level of the mutagenic effect the antibiotics might be arranged as follows with respect to the decrease in their activity : carminomycin -- -- doxorubicin -- -- daunomycin . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
168,
179
]
} | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
186,
196
]
} |
toxicity of doxorubicin prepared with an original chemical method from rubomycin ( daunomycin ) was studied on albino rats and dogs . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
12,
23
]
} | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
83,
93
]
} |
the results suggest that antigenic epitopes are shared among similar pbps from related species and even among different pbps within the same species . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
25,
34
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
35,
43
]
} |
difloxacin ( a-56619 ) and a-56620 , two novel fluoroquinolones , were tested in comparison with ciprofloxacin , cefoxitin , and combined clindamycin and gentamicin in the treatment of experimentally induced intraabdominal abscess associated with bacteroides fragilis . | NA | {
"id": "C0949665",
"name": "fluoroquinolones",
"pos": [
47,
63
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
97,
110
]
} |
insulin infusion had no effect on food intake or body weight of the obese rats relative to their saline-infused controls ( change in body weight : saline ( n = 5 ) , -14 +/- 23 g ; | NA | {
"id": "C0005910",
"name": "body weight",
"pos": [
49,
60
]
} | {
"id": "C0005911",
"name": "change in",
"pos": [
123,
132
]
} |
growth experiments and oxygen uptake rates with other chlorinated aromatic compounds revealed a high degree of specificity of the initial dioxygenase . cis-1,2-dihydroxycyclohexa-3,5-diene oxidoreductase and 1,2-pyrocatechase , but not 2,3-pyrocatechase , were found in cell extracts , while 3,6-dichlorocatechol and ( 2... | NA | {
"id": "C0599874",
"name": "dioxygenase",
"pos": [
138,
149
]
} | {
"id": "C0054859",
"name": "pyrocatechase",
"pos": [
240,
253
]
} |
on the distributive pattern of acetylcholinesterase ( ache ) and butyrylcholinesterase ( bche ) in the medulla oblongata of the golden hamster ( mesocricetus auratus ) . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
31,
51
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
65,
86
]
} |
histochemical study on the distributive patterns of acetylcholinesterase ( ache ) and butyrylcholinesterase ( bche ) , amongst the constituents of the medulla oblongata of golden hamster ( mesocricetus auratus ) , viewed through the angle of the possible topographical and functional linkage of the two enzymes , have pr... | NA | {
"id": "C0001044",
"name": "ache",
"pos": [
75,
79
]
} | {
"id": "C0008429",
"name": "bche",
"pos": [
357,
361
]
} |
naturally , such results have led to a detailed discussion in the contribution culminating in a proposition that ache and bche ( amongst the locales studied ) seems to be intimately linked in the neuro-physiological functioning undergoing in the regions of the medulla oblongata of golden hamster . | NA | {
"id": "C0001044",
"name": "ache",
"pos": [
113,
117
]
} | {
"id": "C0008429",
"name": "bche",
"pos": [
122,
126
]
} |
furthermore , inhibition of forskolin-activated ac by gdp and its analog may be a useful index in analyzing the degree of guanine nucleotide potentiation of this enzyme . | NA | {
"id": "C0018340",
"name": "gdp",
"pos": [
54,
57
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
122,
140
]
} |
the postpubertal decline in constitutive cytochrome p-450p levels in female but not male rats was paralleled by a female-specific , age-dependent decline in the rate of digitoxin sugar cleavage ( i.e. , digitoxosyl oxidation of digitoxin to 15'-dehydrodigitoxin and digitoxosyl cleavage to digitoxigenin bisdigitoxoside ... | NA | {
"id": "C0012258",
"name": "digitoxin",
"pos": [
169,
178
]
} | {
"id": "C0012257",
"name": "digitoxigenin",
"pos": [
290,
303
]
} |
in the current study , we demonstrate that 1,25 ( oh ) 2d3 also regulates 25-hydroxyvitamin d3 [ 25 ( oh ) d3 ] metabolism in hl-60 cells . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
74,
94
]
} | {
"id": "C2713074",
"name": "25 ( oh ) d3",
"pos": [
97,
109
]
} |
the synthesis of both proteins appeared to be unaffected in the mutant , as the precursor forms of both proteins accumulated to the same extent when processing in vivo was blocked by cccp . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
4,
13
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
104,
112
]
} |
cellular thiols were rapidly depleted and glutathione ( gsh ) was converted to a quinone conjugate without oxidation to glutathione disulfide . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
56,
59
]
} | {
"id": "C0061516",
"name": "glutathione",
"pos": [
120,
131
]
} |
however , the disulfated disaccharide content of the dermatan sulfate chains was reduced by tunicamycin in a dose-dependent manner , implying that the n-linked oligosaccharides may be involved in the function of a sulfotransferase which is responsible for sulfation of the iduronic acid residues . | NA | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
25,
37
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
160,
176
]
} |
and the release rate of the soluble enzyme was greater than that of the membranous isozymes , indicating that the soluble enzyme might be a main source of the induced serum alp . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
83,
91
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
122,
128
]
} |
these experiments indicate that the 4-s protein does not appear to be a subunit of the 8-s protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
40,
47
]
} | {
"id": "C0599220",
"name": "subunit",
"pos": [
72,
79
]
} |
to identify residues which might impart transport capability to the intramembranous regions of transport proteins , we surveyed available data for the 9991 amino acids contained in the aqueous and intramembranous regions of 24 integral membrane proteins : 10 transport ( t ) proteins and 14 nontransport ( nt ) proteins ... | NA | {
"id": "C0007292",
"name": "transport",
"pos": [
40,
49
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
311,
319
]
} |
comparison of aqueous and membrane domain composition between protein categories revealed a statistically similar distribution of residues in aqueous domains , but significant differences in membrane domains : seven residues ( asn , asp , gln , glu , phe , pro , tyr ) were preferred in membrane regions of t proteins , ... | NA | {
"id": "C0025252",
"name": "membrane",
"pos": [
26,
34
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
309,
317
]
} |
comparison of aqueous and membrane domain composition between protein categories revealed a statistically similar distribution of residues in aqueous domains , but significant differences in membrane domains : seven residues ( asn , asp , gln , glu , phe , pro , tyr ) were preferred in membrane regions of t proteins , ... | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
239,
242
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
245,
248
]
} |
we evaluated the anticancer effect of uft , which is composed of 1- ( 2-tetrahydrofuryl ) -5-fluorouracil ( tegafur ) and uracil in a molar ratio of 1:4 , for prostatic carcinoma ( du-145 ) in nude mice , and the effect of 5-fluorouracil ( 5-fu ) in vitro . | NA | {
"id": "C0016778",
"name": "tegafur",
"pos": [
108,
115
]
} | {
"id": "C0016360",
"name": "5-fu",
"pos": [
240,
244
]
} |
we evaluated the anticancer effect of uft , which is composed of 1- ( 2-tetrahydrofuryl ) -5-fluorouracil ( tegafur ) and uracil in a molar ratio of 1:4 , for prostatic carcinoma ( du-145 ) in nude mice , and the effect of 5-fluorouracil ( 5-fu ) in vitro . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
99,
105
]
} | {
"id": "C0016360",
"name": "5-fu",
"pos": [
240,
244
]
} |
the concentration of 5-fu in the tumor reached higher levels in the group administered uft in comparison with the tegafur group . | NA | {
"id": "C0016360",
"name": "fu",
"pos": [
23,
25
]
} | {
"id": "C0016778",
"name": "tegafur",
"pos": [
114,
121
]
} |
effects of psk on the immunologic responsiveness in tumor-bearing animals were investigated using syngeneic or allogeneic tumors in mice ( lewis lung carcinoma , b16 melanoma , meth a fibrosarcoma , adenocarcinoma 755 , x5563 plasmacytoma , colon 26 , mopc 31c myeloma , sarcoma 180 and ehrlich carcinoma ) , rats ( bc47... | NA | {
"id": "C0243038",
"name": "lewis lung carcinoma",
"pos": [
139,
159
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
329,
338
]
} |
a randomized clinical trial comparing epirubicin ( epi ) and doxorubicin ( dx ) was conducted in patients with advanced or recurrent breast cancer . | NA | {
"id": "C0014582",
"name": "epirubicin",
"pos": [
38,
48
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
61,
72
]
} |
the dosage employed was 60 mg/m2 for epi and 40 mg/m2 for dx at intervals of three weeks . | NA | {
"id": "C0014582",
"name": "epi",
"pos": [
37,
40
]
} | {
"id": "C0013089",
"name": "dx",
"pos": [
58,
60
]
} |
there were 40 patients entered into the epi group and 39 into the dx group . | NA | {
"id": "C0014582",
"name": "epi",
"pos": [
40,
43
]
} | {
"id": "C0013089",
"name": "dx",
"pos": [
66,
68
]
} |
the response rate was 56.3 % in the epi group ( 5 cr and 13 pr among 32 evaluable patients ) , and 35.5 % in the dx group ( 1 cr and 10 pr among 31 evaluable patients ) , and the difference between both groups was statistically significant ( p less than 0.05 ) by u-test . | NA | {
"id": "C0014582",
"name": "epi",
"pos": [
36,
39
]
} | {
"id": "C0013089",
"name": "dx",
"pos": [
113,
115
]
} |
the present study suggests that in human keratinocytes uvb irradiation induces the release of arachidonic acid from the cellular lipids and that the major source of the released arachidonic acid is phosphatidylethanolamine . | NA | {
"id": "C0022567",
"name": "uvb irradiation",
"pos": [
55,
70
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
120,
128
]
} |
changes in rates of sebum secretion were evaluated indirectly by measuring the ratio of wax esters/ ( cholesterol + cholesterol esters ) in the subjects ' skin surface lipid . | NA | {
"id": "C0043076",
"name": "wax",
"pos": [
88,
91
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
168,
173
]
} |
measurements of rheumatoid factor ( rf ) and antinuclear antibodies ( ana ) by conventional methods define subpopulations of patients with ra and in a few recent studies an association of human leucocyte antigens ( hla ) undoubtedly indicates the immunogenetic differences in the susceptibility of ra patients with diffe... | NA | {
"id": "C0003243",
"name": "antinuclear antibodies",
"pos": [
45,
67
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
335,
349
]
} |
in addition , recent intraoperative measurements of coronary reserve in individual obstructed vessels of patients with multivessel coronary disease performed with a suction doppler probe indicate that , in the intermediate range ( 10 % to 90 % diameter stenosis ) , percent stenosis measurements of coronary lesions by a... | NA | {
"id": "C0010068",
"name": "coronary disease",
"pos": [
131,
147
]
} | {
"id": "C0242231",
"name": "stenosis",
"pos": [
274,
282
]
} |
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