text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
furthermore , we demonstrate that a met-enkephalin analog ( d-ala2-mephe4-met- ( o ) -ol-enkephalin , fk 33-824 , sandoz , basel , switzerland : damme ) inhibits in a dose-dependent manner the acrosome reaction induction . | NA | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
36,
50
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
89,
99
]
} |
furthermore , we demonstrate that a met-enkephalin analog ( d-ala2-mephe4-met- ( o ) -ol-enkephalin , fk 33-824 , sandoz , basel , switzerland : damme ) inhibits in a dose-dependent manner the acrosome reaction induction . | NA | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
36,
50
]
} | {
"id": "C0949300",
"name": "damme",
"pos": [
145,
150
]
} |
g adbpde = 0.149 x g ad org . matter x 0.80 x 0.72 ( adbpde = apparently digestible pure bacteria protein at the duodenum , dependent on energy release in the reticulo-rumen ; g adbpdn = g cp x ( degradation quotacp ) x 0.80 x 0.72 ( adbpdn = apparently digestible pure bacteria protein at the duodenum , dependent on cp... | NA | {
"id": "C0004627",
"name": "bacteria protein",
"pos": [
89,
105
]
} | {
"id": "C0033684",
"name": "cp",
"pos": [
515,
517
]
} |
the most significant lesions of the underlying dura matter are observed in cases of large focal lmh and hematomas . | NA | {
"id": "C0019080",
"name": "lmh",
"pos": [
96,
99
]
} | {
"id": "C0018944",
"name": "hematomas",
"pos": [
104,
113
]
} |
to study the frequency of association between two common colonic disease in our midst , chagasic megacolon and diverticular disease , we reviewed the barium enemas of 243 patients aged more than 35 years . | NA | {
"id": "C0009373",
"name": "colonic disease",
"pos": [
57,
72
]
} | {
"id": "C0025160",
"name": "megacolon",
"pos": [
97,
106
]
} |
an intraocular-lens abrasion test , vital dye staining , and scanning electron microscopy were used for an in vitro comparison of endothelial protection offered by four viscous solutions of 1 % sodium hyaluronate ( healon ) , 3 % sodium hyaluronate ( amvisc ) , 4 % chondroitin sulfate ( viscoat ) , and 2 % methylcellul... | NA | {
"id": "C0020196",
"name": "hyaluronate",
"pos": [
201,
212
]
} | {
"id": "C0087000",
"name": "sodium",
"pos": [
230,
236
]
} |
the role of opioid peptides such as beta-endorphin and the enkephalins in the control of development of respiration in the newborn is discussed . | NA | {
"id": "C0205753",
"name": "opioid",
"pos": [
12,
18
]
} | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
59,
70
]
} |
more than half of the trainees developed a variety of arrhythmias , including pvc , svpc , a-v dissociation , s-a block , and atrial fibrillation ( af ) . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
54,
65
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
126,
145
]
} |
in the present study , we have quantified the effects of other anticholinergic drugs on increments in core temperature and have derived the following potencies relative to atropine : imipramine 0.004 , amitriptyline 0.02 , chlorpromazine 0.1 , atropine 1 , l-hyoscyamine 2 , atropine methyl nitrate 4 , and scopolamine 1... | NA | {
"id": "C0004259",
"name": "atropine",
"pos": [
172,
180
]
} | {
"id": "C0596004",
"name": "l-hyoscyamine",
"pos": [
257,
270
]
} |
in the present study , we have quantified the effects of other anticholinergic drugs on increments in core temperature and have derived the following potencies relative to atropine : imipramine 0.004 , amitriptyline 0.02 , chlorpromazine 0.1 , atropine 1 , l-hyoscyamine 2 , atropine methyl nitrate 4 , and scopolamine 1... | NA | {
"id": "C0004259",
"name": "atropine",
"pos": [
172,
180
]
} | {
"id": "C0128170",
"name": "atropine methyl nitrate",
"pos": [
275,
298
]
} |
the time course of cyclic amp alterations was correlated with the changes in adenine nucleotide and protein biosynthesis . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
19,
29
]
} | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
77,
95
]
} |
in isoproterenol-elicited cardiac hypertrophy , the elevation of the cyclic amp content was one of the earliest metabolic alterations preceding the enhancement of the biosynthesis of adenine nucleotides and proteins . beta-receptor blockade with propranolol abolished the increase in adenine nucleotide synthesis . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
69,
79
]
} | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
284,
302
]
} |
in triiodothyronine-elicited hypertrophy , the cyclic amp level was increased very early , but beta-receptor blockade did not prevent hypertrophy nor the enhancement of cardiac adenine nucleotide biosynthesis , although the positive chronotropic and inotropic effects of triiodothyronine were abolished . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
47,
57
]
} | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
177,
195
]
} |
comparison of the sequence of chicken enolase with the two yeast enolase isoenzyme sequences shows that the enzyme is strongly conserved , with 60 % of the residues identical . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
73,
82
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
108,
114
]
} |
methane mono-oxygenase was shown to be well adapted to the oxidation of methane compared with other straight-chain alkanes . | NA | {
"id": "C0025617",
"name": "methane",
"pos": [
0,
7
]
} | {
"id": "C0002065",
"name": "alkanes",
"pos": [
115,
122
]
} |
the phorbol ester , phorbol 13-myristate 12-acetate ( pma ) inhibits by 80 % both inositol phosphate accumulation and increased precursor incorporation . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
4,
17
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
20,
27
]
} |
the best p-nitrophenyl ester substrates were benzyloxycarbonyl-tyr p-nitrophenyl ester ( kcat./km 3,536,000 m-1 x s-1 ) , benzyloxycarbonyl-leu p-nitrophenyl ester ( kcat./km 2,250,000 m-1 x s-1 ) and benzyloxycarbonyl-phe p-nitrophenyl ester ( kcat./km 1,000,000 m-1 x s-1 ) consistent with a preference for aliphatic o... | NA | {
"id": "C0031453",
"name": "phe",
"pos": [
16,
19
]
} | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
322,
342
]
} |
the mean rate of the reaction is 1.57 +/- 0.38 ( s.d . ) nmol of bilirubin degraded/min per mg of mitochondrial protein ( munits/mg of protein ) . | NA | {
"id": "C0949610",
"name": "mitochondrial protein",
"pos": [
98,
119
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
135,
142
]
} |
the primary structure of component 8c-1 , a subunit protein of intermediate filaments in wool keratin . | NA | {
"id": "C0021769",
"name": "protein",
"pos": [
52,
59
]
} | {
"id": "C0010803",
"name": "keratin",
"pos": [
94,
101
]
} |
the protein has an unusual amino acid composition : 42 % of the residues are alanine and only 14 of the 20 common amino acid residues are present . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
77,
84
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
114,
124
]
} |
a high loading efficiency was demonstrated for small impermeants ( cyclic gmp , atp , arsenazo iii ) as well as proteins ( albumin ) ; | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
112,
120
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
123,
130
]
} |
diffuse surface immunofluorescence and brighter intracellular immunofluorescence in granules were observed in these cells in the first few days of culture , but by the fourth day no immuno-positive cells remained and the fibroblasts that grew to confluence were somewhat different in morphology . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
116,
121
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
221,
232
]
} |
the interaction of bovine factor ix , its activation intermediate , factor ix alpha , and its activation products , factor ixa alpha and factor ixa beta , with acidic phospholipid vesicles of various compositions . | NA | {
"id": "C0015491",
"name": "factor ix",
"pos": [
26,
35
]
} | {
"id": "C0015494",
"name": "factor ixa",
"pos": [
137,
147
]
} |
the interactions of bovine factor ix , its activation intermediate , factor ix alpha , and its activation products , factor ixa alpha and factor ixa beta , with phospholipid vesicles , of mean radius of approx . | NA | {
"id": "C0015491",
"name": "factor ix",
"pos": [
27,
36
]
} | {
"id": "C0015494",
"name": "factor ixa",
"pos": [
138,
148
]
} |
for factor ix , factor ix alpha , factor ixa alpha and factor ixa beta , the dissociation constants , at saturating levels of ca2+ , are independent of the ps concentration in the vesicle after levels of 20-30 % ( w/w ) have been reached , and attain minimum values of approx . | NA | {
"id": "C0015491",
"name": "factor ix",
"pos": [
4,
13
]
} | {
"id": "C0015494",
"name": "factor ixa",
"pos": [
55,
65
]
} |
the amount of protein bound per vesicle particle is independent of the ps content , above 20 % ps , for factor ix and factor ixa beta , with values of approx . | NA | {
"id": "C0015491",
"name": "factor ix",
"pos": [
104,
113
]
} | {
"id": "C0015494",
"name": "factor ixa",
"pos": [
118,
128
]
} |
antagonistic effects of hexose 1,6-bisphosphates and fructose 2,6-bisphosphate on the activity of 6-phosphofructokinase purified from honey-bee flight muscle . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
24,
30
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
53,
61
]
} |
however , in the presence of suitable hydrogen acceptors , such as dichlorophenolindophenol , it catalyzes an artificial reaction , the oxidative decarboxylation of 2-oxoacids to the corresponding carboxylic acids . | NA | {
"id": "C0022618",
"name": "oxoacids",
"pos": [
167,
175
]
} | {
"id": "C0007066",
"name": "carboxylic acids",
"pos": [
197,
213
]
} |
acetylcholinesterases , butyrylcholinesterases , and carboxylesterases appear to form kinetically a homologous enzyme series with respect to many substrates and inhibitors . | NA | {
"id": "C0008429",
"name": "butyrylcholinesterases",
"pos": [
24,
46
]
} | {
"id": "C0007067",
"name": "carboxylesterases",
"pos": [
53,
70
]
} |
the present paper evaluates the interaction of aprophen with acetylcholinesterases , butyrylcholinesterases , and carboxylesterases with respect to protecting the enzyme from organophosphate and carbamate inhibition , accelerating pralidoxime iodide ( 2-pam ) regeneration of the diisopropylphospho-enzyme , and comparin... | NA | {
"id": "C0008429",
"name": "butyrylcholinesterases",
"pos": [
85,
107
]
} | {
"id": "C0007067",
"name": "carboxylesterases",
"pos": [
114,
131
]
} |
the present paper evaluates the interaction of aprophen with acetylcholinesterases , butyrylcholinesterases , and carboxylesterases with respect to protecting the enzyme from organophosphate and carbamate inhibition , accelerating pralidoxime iodide ( 2-pam ) regeneration of the diisopropylphospho-enzyme , and comparin... | NA | {
"id": "C0008429",
"name": "butyrylcholinesterases",
"pos": [
85,
107
]
} | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
439,
459
]
} |
in 120-hr cultures , theophylline , ibmx , rolipram and ro 20-1724 , all stimulated the release of stable calcium , inorganic phosphate and the lysosomal enzymes , beta-glucuronidase and beta-n-acetylglucosaminidase from mouse calvarial bones . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
21,
33
]
} | {
"id": "C0000096",
"name": "ibmx",
"pos": [
36,
40
]
} |
sterols more polar than cholesterol were also detected in treated fibroblasts and in the cells which underwent chase experiments ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
66,
77
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
89,
94
]
} |
the choleresis coursed with increases in the biliary output of sodium and unaccounted anions , whereas those of chloride , bicarbonate and bile acids were unaffected . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
86,
92
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
112,
120
]
} |
the hepatic values of cytoplasmatic and mitochondrial nadh/nad ratios and of adenine nucleotide concentrations suggest that the increase in blood lactate results rather from a fall in its hepatic utilization that from an increase in its production . | NA | {
"id": "C0027270",
"name": "nad",
"pos": [
54,
57
]
} | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
77,
95
]
} |
chloroquine also enhanced the cytotoxic activity of vincristine , daunorubicin and doxorubicin and , to a lesser extent , teniposide ( vm-26 ) in the cem/vlb100 cells . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
66,
78
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
83,
94
]
} |
catecholaminergic agonists competed for these binding sites in the order l-isoproterenol greater than l-epinephrine greater than l-norepinephrine , which is typical for beta 2-adrenergic receptors . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
104,
115
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
131,
145
]
} |
the binding of trifluoperazine to calmodulin and the two adducts was determined using a hummel-dreyer procedure , and binding of the phenothiazine was found to be characterized by apparent positive cooperativity and an apparent limiting stoichiometry of about seven binding sites per protein molecule . | NA | {
"id": "C0040979",
"name": "trifluoperazine",
"pos": [
15,
30
]
} | {
"id": "C3536886",
"name": "phenothiazine",
"pos": [
133,
146
]
} |
we tested the in vitro effects of 5 different h2-receptor antagonists cimetidine ( c ) , oxmetidine ( o ) , ranitidine ( r ) , famotidine ( f ) and nizatidine ( n ) on arylhydrocarbon-hydroxylase , 7-ethoxycoumarin-o-deethylase and 7-ethoxy-resorufin-o-deethylase activity using liver microsomes from man as well as from... | NA | {
"id": "C0003927",
"name": "arylhydrocarbon-hydroxylase",
"pos": [
168,
195
]
} | {
"id": "C0000644",
"name": "7-ethoxycoumarin-o-deethylase",
"pos": [
198,
227
]
} |
we tested the in vitro effects of 5 different h2-receptor antagonists cimetidine ( c ) , oxmetidine ( o ) , ranitidine ( r ) , famotidine ( f ) and nizatidine ( n ) on arylhydrocarbon-hydroxylase , 7-ethoxycoumarin-o-deethylase and 7-ethoxy-resorufin-o-deethylase activity using liver microsomes from man as well as from... | NA | {
"id": "C0003927",
"name": "arylhydrocarbon-hydroxylase",
"pos": [
168,
195
]
} | {
"id": "C0059735",
"name": "7-ethoxy-resorufin-o-deethylase",
"pos": [
232,
263
]
} |
the effects of methyl 2,6-dimethyl-4- ( 2-nitrophenyl ) -5- ( 2-oxo-1,3,2-dioxaphosphorinan-2- yl ) -1,4- dihydropyridine 3-carboxylate ( dhp-218 ) , a new dihydropyridine calcium antagonist , on vascular smooth muscles , cardiac muscles and [ 3h ] -nitrendipine binding to the cardiac muscle and brain membranes were in... | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
106,
121
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
250,
262
]
} |
displacement of [ 3h ] -nitrendipine binding : the pattern of displacement of [ 3h ] -nitrendipine binding by dhp-218 was very similar to that of other 1,4-dihydropyridines but this compound was about 70 times less potent than nifedipine in [ 3h ] -nitrendipine displacement capacity . | NA | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
156,
172
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
249,
261
]
} |
as part of safety evaluation and drug development , 1,4-dihydroxy-5,8-bis [ [ 2- [ ( 2-hydroxyethyl ) amino ] -ethyl ] amino ] -9,10-anthracenedione dihydrochloride ( mitoxantrone , nsc 301739 , cl 232,315 , novantrone ) was tested in the mammalian test systems to determine its mutagenic potential . | NA | {
"id": "C0003174",
"name": "anthracenedione",
"pos": [
133,
148
]
} | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
167,
179
]
} |
also , enhancement of endogenous gaba action through local injection of the benzodiazepines chlordiazepoxide and midazolam or of pentobarbital resulted in anti-aversive effects . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
76,
91
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
92,
108
]
} |
also , enhancement of endogenous gaba action through local injection of the benzodiazepines chlordiazepoxide and midazolam or of pentobarbital resulted in anti-aversive effects . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
76,
91
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
113,
122
]
} |
however , the amino-acid residues involved in metal binding , the half-cystine residues forming the intermolecular disulfide bridge , one of the arginine and some glycine and proline residues are conserved in all eleven cu-zn superoxide dismutases . | NA | {
"id": "C0002520",
"name": "amino-acid",
"pos": [
14,
24
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
163,
170
]
} |
there was a marked decrease in the rates of interaction of the pittsburgh mutant with both human neutrophil elastase and porcine pancreatic elastase , the inhibitor being converted into lower molecular mass fragments after interaction with either enzyme . | NA | {
"id": "C0064833",
"name": "human neutrophil elastase",
"pos": [
91,
116
]
} | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
129,
148
]
} |
after this , the enzyme is able to bind the lectin even at ph 8 where no interaction takes place between the dissolved proteins . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
44,
50
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
119,
127
]
} |
with a modified boyden chamber , water-soluble components from a 4 m guanidinium chloride extract of demineralized adult bovine bone matrix were found to stimulate the directional migration of these chick embryonic limb bud mesenchymal cells as well as embryonic muscle-derived fibroblasts and cells derived from embryon... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
278,
289
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
294,
299
]
} |
arterial pressure and heart rate , and plasma noradrenaline and adrenaline concentrations were measured throughout the induction sequence . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
46,
59
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
64,
74
]
} |
two main cell types , spindle-shaped and large flattened cells , were identified in fibroblast cultures from synovial tissue explants . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
57,
62
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
84,
94
]
} |
these observations suggest that the biogenesis of acute alcoholic fatty liver in rats involves first the formation of membrane-free lipoproteins of vldl size in the cytoplasm and subsequently their fusion to pre-existing lipid globules . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
132,
144
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
148,
152
]
} |
these observations suggest that the biogenesis of acute alcoholic fatty liver in rats involves first the formation of membrane-free lipoproteins of vldl size in the cytoplasm and subsequently their fusion to pre-existing lipid globules . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
132,
144
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
221,
226
]
} |
we report three homosexual men who developed malaise , fever and a roseola-like exanthema which disappeared over 2 weeks . | NA | {
"id": "C0015231",
"name": "roseola",
"pos": [
67,
74
]
} | {
"id": "C0015230",
"name": "exanthema",
"pos": [
80,
89
]
} |
variant translocation t ( 8 ; 22 ) and abnormalities of chromosome 15 ( q22 ) and 17 ( q12-21 ) in a burkitt 's lymphoma/leukaemia with disseminated intravascular coagulation . | NA | {
"id": "C0040715",
"name": "translocation",
"pos": [
8,
21
]
} | {
"id": "C0008626",
"name": "abnormalities of chromosome",
"pos": [
39,
66
]
} |
cytogenetic investigation revealed a variant burkitt 's translocation t ( 8 ; 22 ) ( q24 ; q11 ) involving the lambda light chain gene region and abnormalities of chromosomes 15 and 17 with breakpoints at q22 and q12 respectively , similar to those observed in the t ( 15 ; 17 ) in acute promyelocytic leukaemia . | NA | {
"id": "C0040715",
"name": "translocation",
"pos": [
56,
69
]
} | {
"id": "C0008626",
"name": "abnormalities of chromosomes",
"pos": [
146,
174
]
} |
we conclude that nomifensine can induce in vivo the production of rbc drug- and/or metabolite-dependent antibodies , autoantibodies , or both in the same patient . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
104,
114
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
117,
131
]
} |
the nmr spectra of the enzyme in native and cyanide forms in h2o indicated that the fifth ligand of the heme iron is the histidyl imidazole with an anionic character and that the sixth coordination site is possibly vacant . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
44,
51
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
148,
155
]
} |
the sodium dodecyl sulfate driven dissociation reactions of daunorubicin ( 1 ) , mitoxantrone ( 2 ) , ametantrone ( 3 ) , and a related anthraquinone without hydroxyl groups on the ring or side chain ( 4 ) from calf thymus dna , poly [ d ( g-c ) ] 2 , and poly [ d ( a-t ) ] 2 have been investigated by stopped-flow kine... | NA | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
81,
93
]
} | {
"id": "C0003174",
"name": "anthraquinone",
"pos": [
136,
149
]
} |
it is our conclusion that factor xa when acting in prothrombinase on prothrombin is profoundly protected from inhibition by antithrombin iii in the absence as well as in the presence of heparin . | NA | {
"id": "C0015520",
"name": "factor xa",
"pos": [
26,
35
]
} | {
"id": "C0015518",
"name": "prothrombinase",
"pos": [
51,
65
]
} |
chemically , the lectin was a metalloglycoprotein , composed of 84.0 % protein , 15.8 % carbohydrate , and 0.19 % calcium . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
17,
23
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
71,
78
]
} |
the monosaccharide specificity of the lectin was investigated with the sugar inhibition of the precipitin reaction in gels . | NA | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
4,
18
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
71,
76
]
} |
the pyruvate dehydrogenase component ( e1 ) of the pyruvate dehydrogenase complex catalyzes the decomposition of 3-fluoropyruvate to co2 , fluoride anion , and acetate . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
139,
147
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
148,
153
]
} |
the other analogues studied ( gtp gamma f , gtp gamma ome , gtp gamma oph , and gtp gamma s ) differ from gtp in containing a substituent on the gamma-phosphorus atom or at a nonbridging gamma-oxygen atom . | NA | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
80,
91
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
106,
109
]
} |
the order of effectiveness of these analogues in binding to transducin was gtp gamma s greater than gtp much greater than gppnhp greater than gtp gamma oph greater than gtp gamma ome greater than gppch2p greater than gtp gamma f a second assay measured the effectiveness of gtp gamma s , gppnhp , and gppch2p in eluting ... | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
75,
78
]
} | {
"id": "C0079469",
"name": "gtp gamma",
"pos": [
274,
283
]
} |
the order of effectiveness of these analogues in promoting the transducin-mediated activation of the phosphodiesterase was gtp gamma s greater than gtp much greater than gppnhp greater than gtp gamma oph much greater than gppch2p greater than gtp gamma ome greater than gtp gamma f gtp gamma s was more than a 1000 times... | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
123,
126
]
} | {
"id": "C0079469",
"name": "gtp gamma",
"pos": [
334,
343
]
} |
the thiol of the gizzard myosin heavy chain , which reacts most rapidly with n-ethylmaleimide ( malnet ) , has been located in the subfragment 2 region of myosin rod by fragmentation of [ 14c ] -malnet-labeled myosin with papain and chymotrypsin . | NA | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
25,
43
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
210,
216
]
} |
the rate of increase of mg2+-activated adenosinetriphosphatase ( atpase ) activity , which reflects the loss of ability of myosin to assume the folded , 10s conformation , and the rate of loss of k+-edta-activated activity produced by malnet are both accelerated 5- to 10-fold on addition of atp . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
24,
27
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
65,
71
]
} |
the nonspecific inhibition of viral protein synthesis in infected cells may reflect the role of n , ns , and/or l proteins in the replication and transcription of viral rna or result from duplex formation between the oligomers and complementary , plus-strand viral rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
169,
172
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
259,
268
]
} |
the active-site lysine of rhodopsin was readily modified and prevented from regenerating with 11-cis-retinal and with o-salicylaldehyde and o-phthalaldehyde/mercaptoethanol , two sterically similar aromatic aldehyde containing reagents which react by entirely different mechanisms . | NA | {
"id": "C0028752",
"name": "o-phthalaldehyde",
"pos": [
140,
156
]
} | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
207,
215
]
} |
equilibrium techniques were used to determine the equilibrium free energies of unfolding for the mutant proteins to permit comparison with the wild-type protein . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
97,
112
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
153,
160
]
} |
by using thiols to reduce accessible photoprobes , we have modified the photoaffinity technique so that it tests the accessibility of the leading end of nascent rna to small molecules in solution , as a function of rna chain length . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
161,
164
]
} | {
"id": "C0887909",
"name": "function",
"pos": [
203,
211
]
} |
studies by ultracentrifugation , turbidity measurements , and chemical cross-linking experiments showed that the acto-30-kda peptide complex was dissociated almost completely by the gamma-phosphoryl group containing ligands atp , 5'-adenylyl imidodiphosphate , and pyrophosphate , to a lesser extent by adp , and not at ... | NA | {
"id": "C0001480",
"name": "atp",
"pos": [
224,
227
]
} | {
"id": "C0001506",
"name": "adenylyl",
"pos": [
233,
241
]
} |
since isomerization of an all-trans-retinoid to an 11-cis-retinoid could conceivably occur via the aldehyde , alcohol , or ester forms of vitamin a , it is important to determine the oxidation state of the retinoid that is isomerized in vivo . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
138,
147
]
} | {
"id": "C0035339",
"name": "retinoid",
"pos": [
206,
214
]
} |
in accordance with the results of classical experiments performed in vitro with calf thymus chromatin and the fish protamine salmine , we have observed that this highly basic , small molecular weight protamine can not cause major displacement of histones from nucleosomal core particles at concentrations several times h... | NA | {
"id": "C0036107",
"name": "salmine",
"pos": [
125,
132
]
} | {
"id": "C0033603",
"name": "protamine",
"pos": [
200,
209
]
} |
this distinct electrophoretic mobility probably arises from significant differences in the amino acid composition of the chicken form , which , although lower in serine and particularly in lysine , has a much higher glutamine/glutamate and arginine content , and also a higher proline , glycine , and histidine content ,... | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
91,
101
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
287,
294
]
} |
four amino acid residues ( leu , glu , phe , and his ) greatly increased -beta s , and another four ( asn , gly , ser , and thr ) decreased it . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
5,
15
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
108,
111
]
} |
in the presence of 1.6 m glycylglycine ethyl ester , trypsin removes the carboxyl-terminal glycylglycine of ubiquitin and replaces it with the dipeptide ester . | NA | {
"id": "C0017984",
"name": "glycylglycine",
"pos": [
25,
38
]
} | {
"id": "C0012512",
"name": "dipeptide",
"pos": [
143,
152
]
} |
in temperature studies , below 47 degrees c , the decrease in the activation rate was not related to the thermal denaturation of enzyme or substrate , nor to the choice of activator enzyme ( factor xiia or kallikrein ) , nor to the species of factor xii ( human or bovine ) but to a behavior , designated a thermal trans... | NA | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
191,
202
]
} | {
"id": "C0015525",
"name": "factor xii",
"pos": [
243,
253
]
} |
the locus of the catalysis is accessible from the cytoplasmic side of the membrane and is not at site i , where various anions bind and shift the pka of the deprotonation . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
24,
25
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
120,
126
]
} |
neither is it at site ii , where a few specific anions ( like chloride ) bind to the all-trans pigment . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
48,
54
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
62,
70
]
} |
rabbits immunized with adp-ribose chemically conjugated to carrier proteins developed antibodies reactive against guanine nucleotide binding proteins ( g proteins ) that had been mono-adp-ribosylated by bacterial toxins . | NA | {
"id": "C0007292",
"name": "carrier proteins",
"pos": [
59,
75
]
} | {
"id": "C0086376",
"name": "g",
"pos": [
152,
153
]
} |
luminal cl- replacement by a non-permeant anion ( isethionate ) attenuated the dip which was , however , exaggerated by a permeant anion ( nitrate ) . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
42,
47
]
} | {
"id": "C0028125",
"name": "nitrate",
"pos": [
139,
146
]
} |
a feature that also emerges from these studies is that most cells apparently responding to or infiltrating a tumour do not necessarily participate in its destruction , and it is in this area that experimental tumour systems have particular value . | NA | {
"id": "C0027651",
"name": "tumour",
"pos": [
109,
115
]
} | {
"id": "C0027659",
"name": "experimental tumour",
"pos": [
196,
215
]
} |
furthermore , it is seen that the combination of fourier transform infrared spectroscopy and hydrogen-deuterium exchange is a powerful technique for revealing small differences in protein secondary structure . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
93,
101
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
102,
111
]
} |
cytochrome b5 reconstituted with specifically deuterated hemins has led to the assignment of the resolved 6,7 beta-propionate protons and heme meso protons . | NA | {
"id": "C0018988",
"name": "hemins",
"pos": [
57,
63
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
138,
142
]
} |
calcium concentration and amylase secretion in guinea pig pancreatic acini : interactions between carbachol , cholecystokinin octapeptide and the phorbol ester , 12-o-tetradecanoylphorbol 13-acetate . | NA | {
"id": "C0031586",
"name": "phorbol",
"pos": [
146,
153
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
162,
198
]
} |
the effects of the phorbol ester , 12-o-tetradecanoylphorbol 13-acetate ( tpa ) on amylase secretion and cytoplasmic free calcium concentration ( [ ca2+ ] i ) were investigated in dispersed guinea pig pancreatic acini . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
19,
32
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
35,
71
]
} |
the effect of heparin was dose-dependent and specific ( it was not duplicated by other glycosaminoglycans ) . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
14,
21
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
87,
105
]
} |
in a spectrum from intact spores in a dormant state , only inorganic phosphate and polyphosphates are detected and nucleotides are no longer present in large amounts . | NA | {
"id": "C0031603",
"name": "inorganic phosphate",
"pos": [
59,
78
]
} | {
"id": "C0032575",
"name": "polyphosphates",
"pos": [
83,
97
]
} |
in the camp production assay , elh alpha-fsh beta hybrids exhibited dampened dose-response curves when compared to the ofsh alpha-fsh beta hybrids . | NA | {
"id": "C0060787",
"name": "fsh beta",
"pos": [
41,
49
]
} | {
"id": "C1268876",
"name": "alpha-fsh",
"pos": [
124,
133
]
} |
we have used this method to investigate the intraovarian secretion of catecholamines ( dopamine , norepinephrine , epinephrine ) , oxytocin , beta-endorphin and gamma-amino-butyric acid ( gaba ) during the estrous cycle . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
98,
112
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
115,
126
]
} |
epididymal sperm obtained at vasovasostomy lacked the mhs-5 epitope , a fact that , together with immunolocalization on ejaculated sperm , demonstrated that the mhs-5 antigen functions as a `` '' sperm-coating antigen . '' '' | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
60,
67
]
} | {
"id": "C0003320",
"name": "antige",
"pos": [
167,
173
]
} |
the enhanced effects of d2o on gj can not be accounted for by solvent viscosity alone and may be due to an increased hydration of the channels and/or the transport ions and by isotope effects of hydrogen-deuterium exchange on the channel protein that reduce gj . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
195,
203
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
204,
213
]
} |
the authors analyze the results of 50 computed angiographies made for osteosarcoma and ewing 's sarcoma . | NA | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
70,
82
]
} | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
87,
103
]
} |
patients were given an infection rank based on their numbers of abnormal laboratory indicators of infection . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
23,
32
]
} | {
"id": "C0022882",
"name": "laboratory",
"pos": [
73,
83
]
} |
interaction of leukocytes with cellulose particles is not affected by glucose , galactose , fructose , mannose , or cellobiose . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
31,
40
]
} | {
"id": "C0007630",
"name": "cellobiose",
"pos": [
116,
126
]
} |
a novel reagent gas , consisting of carbon tetrachloride in anhydrous ammonia , was used to achieve maximal sensitivity . | NA | {
"id": "C0017110",
"name": "gas",
"pos": [
16,
19
]
} | {
"id": "C0002607",
"name": "ammonia",
"pos": [
70,
77
]
} |
a combination of negative ion and deuterated ammonia reagent gas was used in making assignments and in demonstrating that the spectra observed were due to intact pgh2 and its stable pge2 and pgd2 isomers formed in the spectrometer . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
45,
52
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
61,
64
]
} |
slightly more of the patients who underwent a lumpectomy followed by radiotherapy had affective disorders , 38 % having an anxiety state , depressive illness , or both . | NA | {
"id": "C0525045",
"name": "affective disorders",
"pos": [
86,
105
]
} | {
"id": "C0011581",
"name": "depressive",
"pos": [
139,
149
]
} |
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