text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
mea explants were incubated for 5 min in the presence of cucl2 ( ionic ) or copper complexed to histidine ( cuhis ) at a concentration of 200 microm each and then for 15 min in the presence of 10 microm pge2 . | NA | {
"id": "C0056593",
"name": "cucl2",
"pos": [
57,
62
]
} | {
"id": "C0009968",
"name": "copper",
"pos": [
76,
82
]
} |
nimodipine , a calcium channel blocker with high affinity for central dihydropyridine ca2+ channels , produced a dose-dependent suppression of electrically induced seizures in the rabbit . | NA | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
0,
10
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
70,
85
]
} |
the first property was studied using non-hydrolysable gtp analogs ( guanosine 5'-o- ( 3-thio-triphosphate ) or gtp gamma s , and guanosine 5'-imido diphosphate or gpp ( nh ) p ) . | NA | {
"id": "C0018353",
"name": "guanosine",
"pos": [
68,
77
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
111,
122
]
} |
the first property was studied using non-hydrolysable gtp analogs ( guanosine 5'-o- ( 3-thio-triphosphate ) or gtp gamma s , and guanosine 5'-imido diphosphate or gpp ( nh ) p ) . | NA | {
"id": "C0018353",
"name": "guanosine",
"pos": [
68,
77
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
163,
175
]
} |
these results imply that , even in the presence of the high endogenous gtp concentration normally present in the cell ( 10 ( -3 ) m ) , gtp gamma s may bind to the gtp-binding protein . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
71,
74
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
136,
147
]
} |
such an interpretation is consistent with the in vitro competition experiments between gtp and gtp gamma s for adenylate cyclase activation . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
87,
90
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
95,
106
]
} |
experiments were designed using conscious sprague-dawley rats to determine the blood pressure ( bp ) and heart rate ( hr ) responses to intravenous doses of ( 1 ) the adrenal catecholamines noradrenaline ( na ) and adrenaline ( a ) , ( 2 ) adrenal pentapeptides methionine enkephalin ( me ) and leucine enkephalin ( le )... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
193,
203
]
} | {
"id": "C0028351",
"name": "na",
"pos": [
445,
447
]
} |
an electrophysiological study was made of the effects of four adenosine analogues , 2-chloroadenosine ( 2-cia ) , 5'-n-ethylcarboxamidoadenosine ( neca ) , l-n6-phenylisopropyladenosine ( l-pia ) , and 2- ( p-methoxyphenyl ) -adenosine ( cv-1674 ) on neurotransmitter release in the mouse phrenic nerve - hemidiaphragm p... | NA | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
84,
101
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
226,
235
]
} |
an electrophysiological study was made of the effects of four adenosine analogues , 2-chloroadenosine ( 2-cia ) , 5'-n-ethylcarboxamidoadenosine ( neca ) , l-n6-phenylisopropyladenosine ( l-pia ) , and 2- ( p-methoxyphenyl ) -adenosine ( cv-1674 ) on neurotransmitter release in the mouse phrenic nerve - hemidiaphragm p... | NA | {
"id": "C0050789",
"name": "5",
"pos": [
114,
115
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
226,
235
]
} |
an electrophysiological study was made of the effects of four adenosine analogues , 2-chloroadenosine ( 2-cia ) , 5'-n-ethylcarboxamidoadenosine ( neca ) , l-n6-phenylisopropyladenosine ( l-pia ) , and 2- ( p-methoxyphenyl ) -adenosine ( cv-1674 ) on neurotransmitter release in the mouse phrenic nerve - hemidiaphragm p... | NA | {
"id": "C0031484",
"name": "l",
"pos": [
4,
5
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
226,
235
]
} |
the maternal and fetal blood ethanol concentration-time curves were virtually superimposable , which indicated unimpeded bidirectional placental transfer of ethanol in the maternal-fetal unit . | NA | {
"id": "C0684262",
"name": "blood ethanol concentration",
"pos": [
23,
50
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
157,
164
]
} |
the present findings indicate that selective antagonists , such as l-649,923 , may be useful for defining the role of leukotrienes in diseases such as bronchial asthma . | NA | {
"id": "C0006261",
"name": "diseases",
"pos": [
134,
142
]
} | {
"id": "C0004096",
"name": "asthma",
"pos": [
161,
167
]
} |
a variety of selective and nonselective inhibitors of cyclooxygenase or 5-lipoxygenase were shown to affect active tension in a manner consistent with the conclusion that a cyclooxygenase product , probably prostaglandin f ( pgf2 alpha ) and not thromboxanes was chiefly responsible . | NA | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
207,
222
]
} | {
"id": "C0012471",
"name": "pgf2 alpha",
"pos": [
225,
235
]
} |
chemical studies involving smith degradation , acid hydrolysis , and n-acetylation revealed that the polysaccharide product has a backbone made up of trisaccharide repeating units comprising glucose , n-acetylmannosaminuronic acid , and n-acetylglucosamine and that the main oligosaccharide moieties of the glycolipids w... | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
101,
115
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
275,
290
]
} |
chemical studies involving smith degradation , acid hydrolysis , and n-acetylation revealed that the polysaccharide product has a backbone made up of trisaccharide repeating units comprising glucose , n-acetylmannosaminuronic acid , and n-acetylglucosamine and that the main oligosaccharide moieties of the glycolipids w... | NA | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
150,
163
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
275,
290
]
} |
lesions were characterized by a neutrophilic bronchitis and bronchiolitis with alveolitis in the surrounding tissue . | NA | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
45,
55
]
} | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
60,
73
]
} |
this naturalistic pilot study of desipramine hydrochloride treatment in elderly dsm iii diagnosed depressives demonstrated that therapeutic response was related to desipramine plasma levels and that a desipramine plasma concentration of 200 nmol/l significantly differentiated responders from non-responders . | NA | {
"id": "C0700529",
"name": "desipramine hydrochloride",
"pos": [
33,
58
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
201,
212
]
} |
25 microm ) , and vitamin e ( dl-alpha-tocopherol acetate ; 100 microm ) , to tumor promoter-treated cultures prevented the inhibition of hepatocyte intercellular communication . | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
18,
27
]
} | {
"id": "C0994472",
"name": "dl-alpha-tocopherol acetate",
"pos": [
30,
57
]
} |
these results indicate that the dna adducts formed by dmcc in rat nasal mucosa dna are more readily expressed as cancer than those formed by bpl or mms . | NA | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
32,
43
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
79,
82
]
} |
all three drugs had a similar inhibitory effect on the different nuclear rna fractions and preferentially reduced nucleolar rna synthesis ( 44-49 % inhibition ) compared to heterogeneous rna synthesis ( 5 % inhibition ) . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
65,
76
]
} | {
"id": "C0035695",
"name": "heterogeneous rna",
"pos": [
173,
190
]
} |
the substitution of chlorine ions by other anions did not prevent the decrease in the rate of diastolic depolarisation due to alinidine but did prevent the effect on the action potential duration . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
29,
33
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
43,
49
]
} |
this might offer therapeutic advantage since the intracellular concentration of adenosine would thereby be increased , allowing an increased rate of incorporation of adenosine into the adenosine triphosphate pool in reoxygenated myocardium . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
80,
89
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
185,
207
]
} |
experiments are described which determined the actual fraction of both s-phases that the rat embryonic fibroblasts ( rat-1 ) cells had to traverse in order to show distinctive differential staining . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
103,
114
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
125,
130
]
} |
this requirement for macrophages could be replaced by the phorbol ester tumour promoter , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
58,
71
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
90,
126
]
} |
the distribution of enkephalin , an endogenous opioid , in tissues and cells of the developing and adult rat was determined by immunocytochemistry with antibodies to met- and leu-enkephalin . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
20,
30
]
} | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
175,
189
]
} |
allopurinol-treated animals have reduced levels of four pterins ( xanthopterin , isoxanthopterin , biopterin and sepiapterin ) as compared with the wild type . | NA | {
"id": "C0033992",
"name": "pterins",
"pos": [
56,
63
]
} | {
"id": "C0043329",
"name": "xanthopterin",
"pos": [
84,
96
]
} |
fifty-three grafts were examined from 3 to 231 days after implantation for myosin atpase , and for heavy chains of fast myosin . | NA | {
"id": "C0027096",
"name": "myosin atpase",
"pos": [
75,
88
]
} | {
"id": "C0027100",
"name": "heavy chains",
"pos": [
99,
111
]
} |
in all instances the authors found in addition to the differentiated cartilaginous component extensive areas formed by round or spindle-shaped non-differentiated mesenchymal elements which on electron microscopic examination had a striking resemblance with ewing 's sarcoma cells or resembled fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
274,
279
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
293,
304
]
} |
lincomycin and clindamycin are still effective against anaerobic bacteria , and their antibacterial activity has also been indicated against gram-positive aerobic cocci , chiefly staphylococcus aureus . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
0,
10
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
15,
26
]
} |
the present emergency due to epidemiological circulation of staphylococci , especially coagulase-negative , methicillin-resistant , and the question of the current validity of the lincosamides , induced us to study the activity of lincomycin and clindamycin against staphylococci belonging to different lyogroups in comp... | NA | {
"id": "C0065002",
"name": "lincosamides",
"pos": [
180,
192
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
231,
241
]
} |
the present emergency due to epidemiological circulation of staphylococci , especially coagulase-negative , methicillin-resistant , and the question of the current validity of the lincosamides , induced us to study the activity of lincomycin and clindamycin against staphylococci belonging to different lyogroups in comp... | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
231,
241
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
246,
257
]
} |
clindamycin showed good antibacterial activity while methicillan-resistant strains showed an increase in resistance to erythromycin and lincomycin . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
0,
11
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
136,
146
]
} |
moxalactam , cefotaxime , ceftazidime and ceftriaxone were revealed as being at least as effective as standard antibiotics in the treatment of meningitis . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
13,
23
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
42,
53
]
} |
when reacted with gsh nepbqi formed both a mono- and a diglutathione conjugate as well as gssg . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
18,
21
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
90,
94
]
} |
we report the first clinical use of a long-acting formulation of d-ser ( tbu ) 6-lhrh ethylamide ( buserelin ) using a novel polymer material . | NA | {
"id": "C0023610",
"name": "lhrh",
"pos": [
81,
85
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
99,
108
]
} |
performance tests of young children in the age range 18 months to 4 1/2 years have been studied in a sample of 425 children living in an inner city area and a rural market town . | NA | {
"id": "C0728836",
"name": "of young children",
"pos": [
18,
35
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
115,
123
]
} |
to identify the predominant subtype of beta-adrenergic receptor , competitive inhibition curves utilizing 125i-cyanopindolol ( 125i-cyp ) as the radiolabel versus isoproterenol , epinephrine , and norepinephrine were generated in membrane preparations from calf heart ( predominant beta 1 ) , calf lung ( predominant bet... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
179,
190
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
197,
211
]
} |
a single-blind cross-over method was used to investigate the effects of ketotifen on the total respiratory resistance response curve to inhalation of a high concentration of allergen ( 1:5 w/v house dust or 1:10 w/v japanese cedar pollen ) and the weal response to intradermal injection of serially diluted allergen ( 1:... | NA | {
"id": "C0524581",
"name": "house dust",
"pos": [
193,
203
]
} | {
"id": "C0002092",
"name": "allergen",
"pos": [
307,
315
]
} |
however , the observation that antibodies to gliadin , and not ovalbumin or casein , fell following gluten avoidance shows that the response to gliadin , at least , is dependent upon continued exposure to antigen . | NA | {
"id": "C2362561",
"name": "gluten",
"pos": [
100,
106
]
} | {
"id": "C0017622",
"name": "gliadin",
"pos": [
144,
151
]
} |
any hcg in the test solution is 'captured ' by the immobilized antibody which is hybridoma derived and specific for the beta-subunit of hcg . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
4,
7
]
} | {
"id": "C0106132",
"name": "beta-subunit",
"pos": [
120,
132
]
} |
plasma fibronectin ( fn ) has been measured by immunonephelometric method in 100 cirrhotic patients and compared with that of 77 normal subjects and with that of 57 patients suffering from liver disorders different from cirrhosis . | NA | {
"id": "C0023895",
"name": "liver disorders",
"pos": [
189,
204
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
220,
229
]
} |
no significant difference has been noted between plasma fn of patients with liver diseases different from cirrhosis and control subjects . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
76,
90
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
106,
115
]
} |
plasma fn has a low sensitivity but a high specificity and a good positive predictive value in distinguishing normals and patients with liver disorders different from cirrhosis . | NA | {
"id": "C0023895",
"name": "liver disorders",
"pos": [
136,
151
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
167,
176
]
} |
a young female patient , with clinical and biochemical manifestations of severe hypercorticism and with the presence of a pituitary adenoma shown by computerized tomography , was thought to have cushing 's syndrome of hypophysial origin . | NA | {
"id": "C0001622",
"name": "hypercorticism",
"pos": [
80,
94
]
} | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
195,
214
]
} |
the effects of the calcium entry blocker nifedipine on blood pressure , heart rate , plasma renin activity , aldosterone , noradrenaline and adrenaline were studied in 23 normotensive subjects in the supine and upright positions . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
123,
136
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
141,
151
]
} |
eight patients , one male and seven females , with no pre-existing hypothalamic-pituitary disease , who developed symptoms of hypopituitarism following cranial irradiation for nasopharyngeal carcinoma were studied 5 years or more after radiotherapy . | NA | {
"id": "C0032002",
"name": "pituitary",
"pos": [
80,
89
]
} | {
"id": "C0020635",
"name": "hypopituitarism",
"pos": [
126,
141
]
} |
prazosin , given during 3 weeks , did not modify supine arterial pressure , heart rate and the plasma levels of angiotensin ii , renin , aldosterone or adrenaline but caused a significant ( p less than 0.05 ) increase of plasma noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
152,
162
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
228,
241
]
} |
to evaluate the effect of changes in plasma catecholamines on the pituitary-adrenal response to ovine corticotrophin releasing factor ( crf ) in normal man , the response to crf alone ( 10 subjects ) was compared responses after infusions of adrenaline ( 6 subjects ) , noradrenaline ( 6 subjects ) and after oral admini... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
242,
252
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
270,
283
]
} |
compared to control levels , plasma adrenaline and noradrenaline concentrations were increased three- and four-fold respectively by exogenous infusions , whereas plasma noradrenaline was significantly lowered by clonidine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
36,
46
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
169,
182
]
} |
plasma levels of testosterone , androstenedione , 17-hydroxyprogesterone , dhea sulphate , cortisol , lh , fsh , and the catecholamines noradrenaline ( ne ) , adrenaline ( epi ) and dopamine were measured in 31 acutely brain injured men , aged 18-95 , shortly after their accident and 4 days later . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
136,
149
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
159,
169
]
} |
use of synthetic glycoconjugates containing the mycobacterium leprae specific and immunodominant epitope of phenolic glycolipid i in the serology of leprosy . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
17,
32
]
} | {
"id": "C0017950",
"name": "glycolipid",
"pos": [
117,
127
]
} |
igg subclasses of antibodies to the dietary antigens gliadin , glycgli ( a gluten component ) , ovalbumin ( oa ) and beta-lactoglobulin ( blg ) were quantified in children with coeliac disease ( cd ) , nine on a gluten-containing diet , 15 on a gluten-free diet , and in appropriate controls . | NA | {
"id": "C0017622",
"name": "gliadin",
"pos": [
53,
60
]
} | {
"id": "C2362561",
"name": "gluten",
"pos": [
245,
251
]
} |
we have previously reported that rabbits immunized with a polyclonal human rheumatoid factor ( rf ) autoantibody preparation could induce anti-idiotypic antibodies bearing the 'internal image ' of the fc fragments of human igg . | NA | {
"id": "C0035448",
"name": "rheumatoid factor",
"pos": [
75,
92
]
} | {
"id": "C0004358",
"name": "autoantibody",
"pos": [
100,
112
]
} |
the repeated isolation of 'internal image ' anti-idiotypic antibodies from rf immunized rabbits suggests that the antigenic conformations recognized by human rf autoantibodies are restricted , and that 'internal image ' anti-idiotypic species to rf may pre-exist within the rabbit immune network . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
161,
175
]
} | {
"id": "C0035448",
"name": "rf",
"pos": [
246,
248
]
} |
such broadly cross-reactive anti-idiotypic reagents provide unique reagents for studying the regulation of rf autoantibody synthesis . | NA | {
"id": "C0035448",
"name": "rf",
"pos": [
107,
109
]
} | {
"id": "C0004358",
"name": "autoantibody",
"pos": [
110,
122
]
} |
amount of antibody is critical for immune complex displacement by charge competition from both rabbit glomeruli and anionic beads . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
10,
18
]
} | {
"id": "C0003313",
"name": "immune complex",
"pos": [
35,
49
]
} |
in 34 patients investigated before specific treatment a broad expression of the b cell repertoire was observed including the production of anti-hapten ( fitc , penicillin , phosphorylcholin ) antibodies , of high levels of antibodies against some heterologous protein antigens ( ovalbumin and tetanus toxoid ) and of aut... | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
192,
202
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
317,
331
]
} |
inappropriate expression of hla class ii ( d/dr ) molecules has been detected in the target cells of most autoimmune diseases including type i ( insulin-dependent ) diabetes . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
106,
125
]
} | {
"id": "C0011854",
"name": "insulin-dependent",
"pos": [
145,
162
]
} |
major histocompatibility complex ( mhc ) expression was assessed by double immunofluorescence technique using monoclonal antibodies to non-polymorphic determinants of class i and class ii molecules and the pancreatic cells were identified by antibodies to islet hormones and other cytoplasmic antigens . gamma-ifn and le... | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
110,
131
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
242,
252
]
} |
major histocompatibility complex ( mhc ) expression was assessed by double immunofluorescence technique using monoclonal antibodies to non-polymorphic determinants of class i and class ii molecules and the pancreatic cells were identified by antibodies to islet hormones and other cytoplasmic antigens . gamma-ifn and le... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
217,
222
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
423,
434
]
} |
peripheral blood mononuclear cells cultured under similar conditions , but without prior separation and irradiation of the e-rosette negative cells also were shown to generate a population of large suppressor cells bearing m1 and m5 determinants . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
0,
34
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
209,
214
]
} |
tests were also positive in 27 % of patients with hyperthyroidism but no clinically apparent eye disease , in 13 % of patients with hashimoto 's thyroiditis without eye disease , in two of 12 patients with subacute thyroiditis , in one of 20 patients with nonimmunological thyroid disorders but in none of 39 normal subj... | NA | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
50,
65
]
} | {
"id": "C0040128",
"name": "thyroid disorders",
"pos": [
273,
290
]
} |
among these , the 40 : b1 monoclonal antibody proved to be specific for the schistosome genus and to detect only adult worm-derived antigens as shown both by immunoprecipitation and with a two-site immunoradiometric assay using the monoclonal as both the solid-phase and the labelled antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
26,
45
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
284,
292
]
} |
a monoclonal antibody and a polyclonal antiserum were applied in precipitation and solid phase immunosorbent techniques using radio- and enzyme-labelled antibody as a tracer to detect the cathodic and anodic antigen respectively . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
2,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
153,
161
]
} |
a monoclonal antibody and a polyclonal antiserum were applied in precipitation and solid phase immunosorbent techniques using radio- and enzyme-labelled antibody as a tracer to detect the cathodic and anodic antigen respectively . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
39,
48
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
153,
161
]
} |
epidermal changes , ia expression on keratinocytes , langerhans cell hyperplasia and lymphocyte infiltration were sought in skin lesions of leprosy : 15 borderline tuberculoid ( bt ) , six borderline lepromatous ( bl ) , 17 lepromatous ( ll ) , 13 erythema nodosum leprosum ( enl ) , six lucio reactions and nine reversa... | NA | {
"id": "C0023343",
"name": "leprosy",
"pos": [
140,
147
]
} | {
"id": "C1562585",
"name": "borderline",
"pos": [
189,
199
]
} |
results indicated that neutralizing antibody was not present before or at the time that monkeys became viremic and that control monkeys who were ifa+ and did not become viremic had high levels of neutralizing antibody . | NA | {
"id": "C0003241",
"name": "ifa",
"pos": [
145,
148
]
} | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
196,
217
]
} |
production of gamma-interferon ( gamma-ifn ) in vitro by peripheral blood mononuclear cells ( pbmc ) from 15 breast-fed and 15 bottle-fed infants has been studied from birth to 9 months of age and compared with production by adult cells . | NA | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
57,
73
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
231,
236
]
} |
to determine the cellular targets , pbmc were fractionated into e-rosetting cells ( t cells ) and non e-rosetting cells ( b cells ) . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
36,
40
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
124,
129
]
} |
in contrast to normal adult cells , blood mnc from the nine children with iga deficiency and age-matched controls ( 2-17 years ) yielded more igg1 than igg2 plasma cells in both control and lps cultures , while the pattern of response to pwm was similar in all groups ( gamma 1 greater than gamma 2 ) . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
15,
21
]
} | {
"id": "C1321301",
"name": "blood mnc",
"pos": [
36,
45
]
} |
to investigate changes of free and sulfoconjugated catecholamines in response to alterations in sympatho-adrenal activity , free and conjugated noradrenaline , adrenaline and dopamine were determined radioenzymatically in plasma of 49 subjects . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
144,
157
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
160,
170
]
} |
during brief vigorous bicycle exercise ( 8 min , maximal heart rate : 177 beats/min ) mean free noradrenaline and adrenaline values of 2.0 and 0.51 nmol/l at rest , increased to 6.7 and 2 nmol/l ( p less than 0.001 ) respectively , at the maximal workload of 200 watt , whereas conjugated noradrenaline and adrenaline de... | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
96,
109
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
307,
317
]
} |
after a rest of 30 min free noradrenaline and adrenaline reached basal values , whereas conjugated noradrenaline and adrenaline remained elevated by 64 and 70 % respectively , compared to pre-exercise concentrations . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
28,
41
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
117,
127
]
} |
it was concluded that conjugated noradrenaline and adrenaline may be used as pools for free noradrenaline and adrenaline during brief vigorous exercise . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
33,
46
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
110,
120
]
} |
the cardiovascular effects of trimazosin , a quinazoline derivative similar in structure to prazosin , were investigated and compared with prazosin in the rabbit . | NA | {
"id": "C0034407",
"name": "quinazoline",
"pos": [
45,
56
]
} | {
"id": "C0032912",
"name": "prazosin",
"pos": [
139,
147
]
} |
previous work from our laboratory has demonstrated a marked inhibitory activity of auranofin ( au ) and gold sodium aurothiomalate ( gst ) on monocyte-macrophage function and an important role for macrophages in the pathogenesis of casein-induced experimental amyloidosis . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
83,
92
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
104,
108
]
} |
previous work from our laboratory has demonstrated a marked inhibitory activity of auranofin ( au ) and gold sodium aurothiomalate ( gst ) on monocyte-macrophage function and an important role for macrophages in the pathogenesis of casein-induced experimental amyloidosis . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
104,
108
]
} | {
"id": "C0018034",
"name": "sodium aurothiomalate",
"pos": [
109,
130
]
} |
aflp is best described as acute hepatocellular dysfunction that occurs in pregnancy , generally during the third trimester or the early puerperium . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
74,
83
]
} | {
"id": "C0032981",
"name": "third",
"pos": [
107,
112
]
} |
it is concluded that enhanced lipogenesis is not the major cause of fatty liver in patients with alcoholic fatty liver . | NA | {
"id": "C0015695",
"name": "fatty liver",
"pos": [
68,
79
]
} | {
"id": "C0015696",
"name": "alcoholic fatty liver",
"pos": [
97,
118
]
} |
during exercise plasma npy-li correlated well with the plasma concentration of na ( r = 0.80 ) , but not with that of adrenaline ( adr ) , suggesting a neuronal origin of npy . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
79,
81
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
118,
128
]
} |
analysis of a trial of adjuvant therapy of breast cancer with poly a : poly u shows the possibility of immunotherapy to prevent the development of late metastases , independently of hormonal status in contrast with standard adjuvant chemotherapy which is only active on early micrometastases in premenopausal women . | NA | {
"id": "C0027627",
"name": "metastases",
"pos": [
152,
162
]
} | {
"id": "C1513276",
"name": "micrometastases",
"pos": [
276,
291
]
} |
sodium and potassium activated adenosine triphosphatase ( na-k atpase ) was extracted from the skin of rana catesbeiana tadpoles and adults . | NA | {
"id": "C0001473",
"name": "adenosine triphosphatase",
"pos": [
31,
55
]
} | {
"id": "C0001479",
"name": "na-k atpase",
"pos": [
58,
69
]
} |
low density areas in the liver on computed tomography ( ct ) may be produced by cysts , abscesses , or tumors . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
80,
85
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
103,
109
]
} |
epstein-barr virus gene expression during primary b-lymphocyte infection , in transformed and burkitt lymphoma-derived cell lines . | NA | {
"id": "C0149678",
"name": "epstein-barr virus",
"pos": [
0,
18
]
} | {
"id": "C0006413",
"name": "burkitt lymphoma",
"pos": [
94,
110
]
} |
since the vldl present during the first 2 days floated at faster rates than those present at 6 days following injection of oestrogen , it appears that newly synthesized apoprotein b ( very likely as lipoprotein b ) can combine with existing lipid micelles in the plasma , thus ultimately dispersing the larger lipid mice... | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
241,
246
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
330,
342
]
} |
in situ hybridization experiments showed that component ib has the properties characteristic of long interspersed repetitive dna rather than tandemly repeated satellite dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
125,
128
]
} | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
159,
172
]
} |
the non-hydrolysable analogue gtp gamma s also potentiates the ca2+-dependent secretory response , but this effect is additive to that seen by thrombin rather than synergistic , as is the case with gtp . | NA | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
30,
41
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
198,
201
]
} |
in both preparations the effects of gtp gamma s are inhibited by 10 microm gtp , even though gtp concentrations up to 1 mm are without effect when added alone . | NA | {
"id": "C0079469",
"name": "gtp",
"pos": [
36,
39
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
93,
96
]
} |
these results are consistent with there being two sites of action for the guanine nucleotides , one at the level of the agonist receptor and activated by gtp or one of its breakdown products , and the other one activated by gtp gamma s -- possibly at the level of protein kinase c itself . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
74,
93
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
224,
227
]
} |
these results are consistent with there being two sites of action for the guanine nucleotides , one at the level of the agonist receptor and activated by gtp or one of its breakdown products , and the other one activated by gtp gamma s -- possibly at the level of protein kinase c itself . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
154,
157
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
224,
235
]
} |
to study this unique ph dependence of the effect of new local anaesthetics , drug-lipid interactions were investigated in liposomes prepared from egg yolk phosphatidylcholine or dimyristoyl phosphatidylcholine . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
155,
174
]
} | {
"id": "C0012456",
"name": "dimyristoyl phosphatidylcholine",
"pos": [
178,
209
]
} |
clobetasol-17-propionate , betamethanone-17-valerate , diflorasone-17,21-diacetate , triamcinolane acetonide , hydrocortisone ( in 10 % urea ) , hydrocortisone butyrate and a mixture of clocortolone-21-pivalate and clocortolone-21-hexynoate were tested . | NA | {
"id": "C0020268",
"name": "hydrocortisone",
"pos": [
111,
125
]
} | {
"id": "C0352536",
"name": "hydrocortisone butyrate",
"pos": [
145,
168
]
} |
animal experiments suggest that a myo-inositol-related defect in nerve sodium-potassium adenosine triphosphatase ( atpase ) is responsible for the acute reversible slowing of nerve conduction in diabetes mellitus . | NA | {
"id": "C0001479",
"name": "sodium-potassium adenosine triphosphatase",
"pos": [
71,
112
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
115,
121
]
} |
short-term effect of malathion on rats ' blood glucose and on glucose utilization by mammalian cells in vitro . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
41,
54
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
62,
69
]
} |
in vitro experiments , using the adrenal tissue , showed that there was an adrenal cortisol response to 1-39 acth but not to regular insulin , arginine vasopressin , angiotensin ii , norepinephrine or epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
183,
197
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
201,
212
]
} |
on the basis of the ultrastructural features , a hamartomatous rather than tumoral origin is suggested for the duodenal lymphangioma . | NA | {
"id": "C0018552",
"name": "hamartomatous",
"pos": [
49,
62
]
} | {
"id": "C0027651",
"name": "tumoral",
"pos": [
75,
82
]
} |
in order to obtain useful information for the design of inhibitors of cathepsin b , an important enzyme in both physiological and pathological processes , the modes of interaction between ligands and thiol proteases ( papain and cathepsin b ) were analyzed . | NA | {
"id": "C0010661",
"name": "thiol proteases",
"pos": [
200,
215
]
} | {
"id": "C0030346",
"name": "papain",
"pos": [
218,
224
]
} |
the antibody f23.1 , as well as an antiserum raised against the constant region of the beta chain , immunoprecipitated receptor dimers from highly purified lyt2+ , l3t4+ thymocytes and from two thymic lymphomas of cortical phenotype which express full size alpha and beta mrna . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
4,
12
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
35,
44
]
} |
when inserted into two selected sites of lamb , a foreign antigen , the c3 epitope from poliovirus , was exposed at the cell surface with its normal antigenic properties . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
75,
82
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
149,
158
]
} |
from the kinetics of continuous labelling of pgk mrna , relative to the labelling of other rnas in the same cultures whose levels do not alter with heat-shock , it was shown that the elevation in pgk mrna in response to temperature upshift reflects primarily an increased synthesis of this mrna and not an alteration of ... | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
9,
17
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
324,
333
]
} |
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