text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the inability of kirromycin to affect the ef-1 alpha/guanine-nucleotide interaction in the presence of ribosomes shows that , differently from ef-tu , the ef-1 alpha x gdp/gtp exchange reaction takes place on the ribosome . | NA | {
"id": "C0018328",
"name": "guanine-nucleotide",
"pos": [
53,
71
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
168,
171
]
} |
the inability of kirromycin to affect the ef-1 alpha/guanine-nucleotide interaction in the presence of ribosomes shows that , differently from ef-tu , the ef-1 alpha x gdp/gtp exchange reaction takes place on the ribosome . | NA | {
"id": "C0018328",
"name": "guanine-nucleotide",
"pos": [
53,
71
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
172,
175
]
} |
the proteoheparan sulphate isolated from the tissue-culture medium contains four heparan sulphate side-chains of 25 kda each , and its core protein has an approximate molecular mass of 50 kda . | NA | {
"id": "C0062503",
"name": "proteoheparan sulphate",
"pos": [
4,
26
]
} | {
"id": "C0019143",
"name": "heparan sulphate",
"pos": [
81,
97
]
} |
the two-dimensional separation of phosphopeptides obtained by tryptic/chymotryptic digestion of 32p-labelled synapsin i indicated that the same peptides were phosphorylated by all the calmodulin-dependent protein kinases . | NA | {
"id": "C0031684",
"name": "phosphopeptides",
"pos": [
34,
49
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
144,
152
]
} |
biliary tract dilatation without obstruction may result from sclerosing cholangitis , pyogenic cholangitis , or bile duct surgery . | NA | {
"id": "C0008313",
"name": "sclerosing",
"pos": [
61,
71
]
} | {
"id": "C0008311",
"name": "cholangitis",
"pos": [
95,
106
]
} |
the distinct profiles of proteoglycan production were maintained by the cells in culture for several weeks , although eventually the amount of large proteoglycan synthesized by the distal tendon fibroblast cultures diminished . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
72,
77
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
195,
205
]
} |
similar or higher concentrations of volatile salts , not containing chloride as an anion , had no shortening effect . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
68,
76
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
83,
88
]
} |
these antibodies bind to a phosphorylated epitope on certain proteins , and therefore the antigens are presumed to be a group of phosphoproteins . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
42,
49
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
90,
98
]
} |
these antibodies bind to a phosphorylated epitope on certain proteins , and therefore the antigens are presumed to be a group of phosphoproteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
61,
69
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
129,
144
]
} |
ten dystrophic cases were studied and compared with twelve suitable control cases , extending the iif analysis to two other representative non-collagenous proteins of the extracellular matrix ( ecm ) , namely fibronectin ( fn ) and laminin ( lm ) . | NA | {
"id": "C0079323",
"name": "proteins",
"pos": [
155,
163
]
} | {
"id": "C0016055",
"name": "fibronectin",
"pos": [
209,
220
]
} |
ten dystrophic cases were studied and compared with twelve suitable control cases , extending the iif analysis to two other representative non-collagenous proteins of the extracellular matrix ( ecm ) , namely fibronectin ( fn ) and laminin ( lm ) . | NA | {
"id": "C0079323",
"name": "proteins",
"pos": [
155,
163
]
} | {
"id": "C0022984",
"name": "laminin",
"pos": [
232,
239
]
} |
quantification of procollagen synthesized in cell cultures and their rate of conversion into collagen were determined both in the culture media and a cell layer extract by deae cellulose chromatography . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
18,
29
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
93,
101
]
} |
the rate of conversion of procollagen into collagen was higher in the pathological cultures than in control cultures . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
26,
37
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
43,
51
]
} |
a 29 year-old-man presenting with advanced metastatic malignant melanoma was successfully imaged using carbon-11 ( 11c ) labeled alpha-aminoisobutyric acid ( aib ) , a synthetic , non-metabolized amino acid transported into viable cells by the a-type , or alanine-preferring , amino acid transport system . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
196,
206
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
256,
263
]
} |
the urinary protein composition changed significantly as the fraction of low molecular weight proteins decreased from 48 % at a gestational age of 29-33 weeks to 24 % in mature infants aged 3 months , the albumin fraction increased from 39 % -46 % and the proportion of higher molecular weight proteins increased from 12... | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
205,
212
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
294,
302
]
} |
to prevent future mental retardation caused by maternal pku , the simultaneous establishment of a register system with a neonatal screening programme , is indicated for the follow-up of pku girls , screening of the whole family of newly discovered pku cases , and to exclude unrecognized maternal pku in women who have g... | NA | {
"id": "C0031485",
"name": "pku",
"pos": [
56,
59
]
} | {
"id": "C0085547",
"name": "maternal pku",
"pos": [
288,
300
]
} |
chronic treatment with desenkephalin-gamma-endorphin ( de gamma e ) , a beta-endorphin fragment with neuroleptic-like properties , administered s.c. twice a day for 7 days at the dose of 10 micrograms/rat , restored the sensitivity to small doses of apomorphine in the hypophysectomized rats . | NA | {
"id": "C0061041",
"name": "gamma-endorphin",
"pos": [
37,
52
]
} | {
"id": "C0014242",
"name": "endorphin",
"pos": [
77,
86
]
} |
depolarization of [ 3h ] inositol-prelabelled rat cortical slices through the elevation of extracellular k+ levels leads to increased accumulation of [ 3h ] inositol phosphates . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
25,
33
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
157,
176
]
} |
these findings would indicate that the interruption of dopaminergic transmission in the myenteric plexus produces an increase in the release of opioid peptides and suggest an inhibitory modulation of opioid peptidergic neurons by dopamine systems at this level . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
55,
67
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
230,
238
]
} |
in contrast to findings with [ 3h ] [ d-ala2 , d-leu5 ] enkephalin binding could not be detected before postnatal day 10 which may be associated with the low affinity and specific activity of dpdpe . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
56,
66
]
} | {
"id": "C0525856",
"name": "dpdpe",
"pos": [
192,
197
]
} |
the b1-kinin receptor agonist desarg9-bk ( 0.4-1.0 microm ) did not decrease rvr but , as lbk , markedly increased rvr in a dose-related manner . | NA | {
"id": "C0006100",
"name": "bk",
"pos": [
38,
40
]
} | {
"id": "C0022474",
"name": "lbk",
"pos": [
90,
93
]
} |
the antinociceptive effects obtained in arthritic rats with morphine , the opioid mu-agonist dago [ d-ala2 , mephe4 , gly-ol5 ] enkephalin , the delta-selective agonist dtlet [ d-thr2 , leu5 ] enkephalyl-thr , and the kappa-agonist u-50,488h were compared to their corresponding effects in normal animals and morphine-pr... | NA | {
"id": "C0525773",
"name": "dago",
"pos": [
93,
97
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
128,
138
]
} |
tachykinin binding sites in guinea pig urinary bladder ( gpub ) , rat salivary gland ( rsg ) , hamster urinary bladder ( hub ) , rat vas deferens ( rvd ) and rat cerebral cortex ( rcc ) were compared using 125i-bolton hunter conjugates of substance p ( 125i-bhsp ) , eledoisin ( 125i-bhe ) and neurokinin a ( 125i-bhnka ... | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
0,
10
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
239,
250
]
} |
tachykinin binding sites in guinea pig urinary bladder ( gpub ) , rat salivary gland ( rsg ) , hamster urinary bladder ( hub ) , rat vas deferens ( rvd ) and rat cerebral cortex ( rcc ) were compared using 125i-bolton hunter conjugates of substance p ( 125i-bhsp ) , eledoisin ( 125i-bhe ) and neurokinin a ( 125i-bhnka ... | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
0,
10
]
} | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
294,
306
]
} |
three isozymes of an enzyme which reduce fructose 1 , 6-diphosphate ( fdp ) to sorbitol 1 , 6-diphosphate ( sdp ) in the presence of nadh have been purified from bovine lens . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
6,
14
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
21,
27
]
} |
serotonin , tryptamine , and 5-methoxytryptamine intensely inhibited the activity while tryptophan , melatonin , n-acetylserotonin , tryptophol , and 5-hydroxyindole acetic acid had no significant effects . | NA | {
"id": "C0036751",
"name": "serotonin",
"pos": [
0,
9
]
} | {
"id": "C0000589",
"name": "5-methoxytryptamine",
"pos": [
29,
48
]
} |
dopamine , tyramine , 3-methyltyramine , and phenylethylamine also inhibited the activity while no particular effects were obtained by adrenaline , noradrenaline , tyrosine , and dopa . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
135,
145
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
148,
161
]
} |
in an additional group of rabbits who were fed the cholesterol diet for 16-28 weeks and in which endothelial denudation was performed just prior to carotid perfusion , removal of carotid artery endothelium did not cause a further enhancement of albumin transport above that observed by cholesterol feeding alone . | NA | {
"id": "C0008395",
"name": "cholesterol diet",
"pos": [
51,
67
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
286,
297
]
} |
within the uncertainties of the available information on sexual behaviour in our society , on the risk of transmission and on the natural history of the infection , the model predicts : the infection will be self-sustaining in the heterosexual as in the homosexual population , the equilibrium prevalence of htlv-iii inf... | NA | {
"id": "C0019693",
"name": "htlv-iii infection",
"pos": [
308,
326
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
692,
696
]
} |
susceptibility testing to four additional beta-lactams ( cefoxitin , cefuroxime , cefotaxime , and piperacillin ) and to four aminoglycosides ( gentamicin , tobramycin , amikacin , and netilmicin ) indicated that antibiotic resistance was widespread and in all species more frequent among methicillin-resistant than amon... | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
69,
79
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
82,
92
]
} |
susceptibility testing to four additional beta-lactams ( cefoxitin , cefuroxime , cefotaxime , and piperacillin ) and to four aminoglycosides ( gentamicin , tobramycin , amikacin , and netilmicin ) indicated that antibiotic resistance was widespread and in all species more frequent among methicillin-resistant than amon... | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
126,
141
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
144,
154
]
} |
a general computational procedure for the modelling of intercalated dna-ligand complexes has been developed , and is used here to model intercalated complexes of the ( + ) -anti and ( - ) -anti enantiomers of benzo [ a ] pyrene diol-epoxide ( bpde ) with cytosine-3',5'-guanosine double-stranded dna sequences ( dcpg ) . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
280,
299
]
} |
increased nuclear cyclin/pcna antigen staining of non s-phase transformed human amnion cells engaged in nucleotide excision dna repair . | NA | {
"id": "C0069115",
"name": "nuclear",
"pos": [
10,
17
]
} | {
"id": "C0072108",
"name": "pcna",
"pos": [
25,
29
]
} |
kasabach-merritt syndrome with consumption coagulopathy occurred in a 5-week-old female infant with a hemangioma on her back . | NA | {
"id": "C0221025",
"name": "kasabach-merritt syndrome",
"pos": [
0,
25
]
} | {
"id": "C0018916",
"name": "hemangioma",
"pos": [
102,
112
]
} |
a direct elisa based on highly purified diphtheria toxoid correlated poorly with the in vivo method but an assay based on capture of toxoid by a non-neutralizing monoclonal antibody produced results that correlated very well . | NA | {
"id": "C0012551",
"name": "diphtheria toxoid",
"pos": [
40,
57
]
} | {
"id": "C0040555",
"name": "toxoid",
"pos": [
133,
139
]
} |
the if protein complement of trichocytes from all three species is characterized by a very similar set of eight highly conserved alpha-keratin polypeptides , comprising four members of the basic ( type ii ; mr 56,500-60,000 ) and four members of the acidic ( type i ; mr 41,000-44,000 ) cytokeratin subfamily . | NA | {
"id": "C0021769",
"name": "if protein",
"pos": [
4,
14
]
} | {
"id": "C0010803",
"name": "cytokeratin",
"pos": [
287,
298
]
} |
primary explant , mass and clonal fibroblast cultures established from bn rat skin and lungs were used to examine changes in cell behaviour associated with aging . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
34,
44
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
125,
129
]
} |
in comparison to fi cells , the level of type-iii-collagen synthesis is slightly elevated in fiii fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
20,
25
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
98,
109
]
} |
the increasing predominance of fiii cells in mass cultures of fibroblasts obtained from donors of increasing ages was consistent with the increased level of collagen synthesis in these cultures . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
62,
73
]
} |
we discuss the age-related changes in the relative abundance of fi , fii and fiii cells in vivo in the context of alterations in fibroblast replacement and changes in connective tissue that occur during aging . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
82,
87
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
129,
139
]
} |
the results showed that the phase of rapid cellular proliferation that follows the structural modulation of smooth-muscle cells is associated with high rates of collagen and elastin synthesis , as measured by the incorporation of 3h-proline into 3h-hydroxyproline and 3h-valylproline , respectively . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
233,
240
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
249,
263
]
} |
measurements of many nutritional variables will be abnormal in patients with inflammatory bowel disease , especially in those with crohn 's disease , but are not always relevant to the clinical management of patients . | NA | {
"id": "C0021390",
"name": "inflammatory bowel",
"pos": [
77,
95
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
131,
147
]
} |
hematological and coagulative-analytical findings are represented in 10 patients aged between 3 months and 12.9 years affected with a typical kawasawski syndrome , a disease which , etiologically , has not been elucidated and which will predominantly occur at the early childhood . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
153,
161
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
166,
173
]
} |
under this condition , the binding was specific since displacement studies showed no inhibition of 125 ( i ) -insulin binding by gh , hcg , acth and glucagon , whereas half maximal inhibition was achieved using 5 10 ( -10 ) m insulin , 3 10 ( -9 ) m igf1 and 2 10 ( -8 ) m proinsulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
110,
117
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
273,
283
]
} |
this procedure progressively drove up the basic blood levels of free adrenaline , noradrenaline and dopamine , while insulin decreased to below normal . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
69,
79
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
82,
95
]
} |
fibroblasts exposed for 48 hours to pooled lipoprotein-poor ( d greater than 1.25 gm/ml ) serum from glucocorticoid-treated patients showed an increased capacity to bind ldl ( p less than .001 ) compared to cells incubated under identical conditions with pooled serum from controls . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
0,
11
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
207,
212
]
} |
the assay for hepatitis d virus rna provides a direct and noninvasive method for the detection of hepatitis d virus in serum and will be useful in the study of the natural history of type d hepatitis , the identification of chronic hepatitis d virus carriers likely to transmit hepatitis d virus and the selection and mo... | NA | {
"id": "C0011226",
"name": "d hepatitis",
"pos": [
188,
199
]
} | {
"id": "C0524911",
"name": "chronic hepatitis d",
"pos": [
224,
243
]
} |
a prospective study of apolipoprotein ai has been undertaken in 581 alcoholic patients and in 100 controls in order to describe the changes of apolipoprotein ai according to the different stages of the alcoholic liver disease , to correlate the changes to serum liver tests and to estimate its diagnosis and prognostic v... | NA | {
"id": "C0003592",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0085201",
"name": "apolipoprotein",
"pos": [
143,
157
]
} |
no significant correlation was found between hsv positivity and a clinical history of oral or genital hsv infection in either the patient or the male partner . | NA | {
"id": "C0019348",
"name": "hsv",
"pos": [
45,
48
]
} | {
"id": "C0019342",
"name": "genital hsv infection",
"pos": [
94,
115
]
} |
a cosmid library was constructed from genomic dna of a human-mouse somatic cell hybrid containing an 11q-16q translocation chromosome as the only human dna . | NA | {
"id": "C0012931",
"name": "constructed",
"pos": [
21,
32
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
152,
155
]
} |
maintenance of pancreatic endocrine cells of the neonatal rat : part viii -- effect of 2-deoxyglucose on insulin biosynthesis and proinsulin mrna activity . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
105,
112
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
130,
140
]
} |
phorbol ester 12-o-tetradecanoylphorbol-13-acetate ( tpa ) , an activator of protein kinase c , suppresses natural , lectin and antibody-dependent killing by normal human lymphocytes in short-term radioisotope release assays . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
0,
13
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
14,
50
]
} |
phorbol ester 12-o-tetradecanoylphorbol-13-acetate ( tpa ) , an activator of protein kinase c , suppresses natural , lectin and antibody-dependent killing by normal human lymphocytes in short-term radioisotope release assays . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
77,
84
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
117,
123
]
} |
eb virus genome-carrying b-cell lines have been double-stained for b-cell activation or maturation antigens and viral antigens using indirect immunofluorescence . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
99,
107
]
} | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
112,
126
]
} |
eight cases of the recently reported 'primary mediastinal clear cell lymphoma of b-cell type ' ( moller et al. , 1986 ) were examined immunohistologically for the expression of cytoplasmic and/or surface antigens of mhc class i and ii with mabs directed against framework determinants of hla-a , b , c ( w6/32 ; b9.12.1 ... | NA | {
"id": "C0019759",
"name": "hla-dp",
"pos": [
324,
330
]
} | {
"id": "C0019754",
"name": "hla-d",
"pos": [
471,
476
]
} |
the cellular distribution , molecular structure and functional characteristics of the membrane antigen defined by mab.198 suggested that this antibody recognizes the complement type 3 receptor ( cr3 ) . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
114,
117
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
142,
150
]
} |
this anti-rabbit cr3 mab will be useful in the characterization of rabbit complement receptors and their involvement in immune reactions . | NA | {
"id": "C0079785",
"name": "cr3",
"pos": [
17,
20
]
} | {
"id": "C0034793",
"name": "complement receptors",
"pos": [
74,
94
]
} |
an antiserum was raised against this preparation which , when tested against rat serum by protein a immunoblotting , showed that the antibodies were directed to 70,000 mw antigens . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
3,
12
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
133,
143
]
} |
a majority of the monoclonal antibodies ( mcab ) produced were demonstrated to recognize epitopes common to all lambda chains or unique to the immunogen . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
89,
97
]
} | {
"id": "C0003320",
"name": "immunogen",
"pos": [
143,
152
]
} |
both the formation of 7- ( 2-oxoethyl ) guanine by ethyl carbamate and vinyl carbamate , and the much higher activity of the latter compound , strongly support the existence of the metabolic activation pathway , ethyl carbamate -- -- vinyl carbamate -- -- epoxyethyl carbamate , as proposed by dahl et al . | NA | {
"id": "C0041964",
"name": "ethyl carbamate",
"pos": [
51,
66
]
} | {
"id": "C0006948",
"name": "carbamate",
"pos": [
267,
276
]
} |
in addition to the expected methylated purines ( o6-methylguanine , 7-methylguanine and 3-methyladenine ) , 0.6 % of the total product was s6-methyl-6-thioguanine . | NA | {
"id": "C0034140",
"name": "purines",
"pos": [
39,
46
]
} | {
"id": "C0039902",
"name": "thioguanine",
"pos": [
151,
162
]
} |
the amino group of cytosine adds to the double bond of acrolein , while the aldehyde binds to the 3-position , forming a new ring . | NA | {
"id": "C0001204",
"name": "acrolein",
"pos": [
55,
63
]
} | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
76,
84
]
} |
to determine the structures of the dna adducts of two cyclic nitrosamines , n-nitrosopyrrolidine and n-nitrosomorpholine , the model compounds , alpha-acetoxy-n-nitrosopyrrolidine , 4- ( carbethoxynitrosamino ) butanal and 2- ( carbethoxynitrosamino ) ethoxyacetaldehyde , were allowed to react with deoxyguanosine in th... | NA | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
61,
73
]
} | {
"id": "C0027253",
"name": "n-nitrosopyrrolidine",
"pos": [
159,
179
]
} |
the genotoxic activity of two bifunctional furocoumarins , 8- and 5-methoxypsoralen ( 8-mop and 5-mop ) , and the newly developed monofunctional furocoumarin , 7-methyl-pyrido ( 3,4-c ) psoralen ( mepyps ) , was determined in diploid yeast . | NA | {
"id": "C0016859",
"name": "furocoumarin",
"pos": [
43,
55
]
} | {
"id": "C0016072",
"name": "psoralen",
"pos": [
186,
194
]
} |
for analysis by isb , alkylated dna is heat-denatured and immobilized on nitrocellulose filters prior to exposure to the respective mab and subsequent binding of a second ( 125i-labelled or biotinylated ) antibody . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
132,
135
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
205,
213
]
} |
all three known etheno adducts of dna were tentatively identified in dna reacted in vitro . | NA | {
"id": "C0242958",
"name": "adducts",
"pos": [
23,
30
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
69,
72
]
} |
however , it was concluded that this phenomenon was artificial due to the following reasons : kallikrein was only chemotactic in the presence of bovine serum albumin ( bsa ) in the chamber but not when bsa was substituted by guinea pig serum albumin or egg albumin . | NA | {
"id": "C0036774",
"name": "bsa",
"pos": [
168,
171
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
236,
249
]
} |
positive charges on protamine are of primary importance because the polyanion heparin completely inhibits protamine sulfate-induced enzyme release . | NA | {
"id": "C0033603",
"name": "protamine",
"pos": [
20,
29
]
} | {
"id": "C0033602",
"name": "protamine sulfate",
"pos": [
106,
123
]
} |
carrageenan , a sulfated polyanionic polysaccharide , is commonly used to induce inflammation in experimental animals , and this model is used to screen for the effectiveness of antiinflammatory drugs . | NA | {
"id": "C0007289",
"name": "carrageenan",
"pos": [
0,
11
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
37,
51
]
} |
thrombin , a highly specific coagulation factor , can rapidly trigger lysozyme release from human neutrophils without concomitant activation of the 5-lipoxygenase pathway . | NA | {
"id": "C0040018",
"name": "thrombin",
"pos": [
0,
8
]
} | {
"id": "C0005789",
"name": "coagulation factor",
"pos": [
29,
47
]
} |
neither antibody localized to tumour in vivo , and the methotrexate conjugates were not significantly cytotoxic for tumour cells in vitro , in contrast to similar conjugates simultaneously prepared with a proven anti-tumour mab ( 791t/36 ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
8,
16
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
224,
227
]
} |
the autologous cell lines were established from peripheral blood mononuclear cells ( pbmc ) from each monkey by co-cultivation with lethally irradiated mt-2 cells producing htlv-i . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear",
"pos": [
48,
76
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
157,
162
]
} |
therefore , the positive inotropic and chronotropic effects of ch-pbmc were due to the action of cells from the t4 subset . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
66,
70
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
97,
102
]
} |
the device is composed of an enrichment unit operating continuously on the basis of gas extraction into polydisperse aerosol of a liquid transferring sulfur dioxide from liter amount of air into microliter amount of liquid . | NA | {
"id": "C0017110",
"name": "gas",
"pos": [
84,
87
]
} | {
"id": "C0038777",
"name": "sulfur dioxide",
"pos": [
150,
164
]
} |
the analytical response is obtained few tenths of seconds after the gas contaminated with sulfur dioxide has entered the enrichment unit . | NA | {
"id": "C0017110",
"name": "gas",
"pos": [
68,
71
]
} | {
"id": "C0038777",
"name": "sulfur dioxide",
"pos": [
90,
104
]
} |
ewing 's sarcoma cells and normal human fibroblasts were sensitized to an equal extent by either 8 mm 3ab or 4 mm bz . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
17,
22
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
40,
51
]
} |
of these compounds , purine , adenine and hypoxanthine resembled caffeine in sensitizing spores to radiation , while theobromine , xanthine and theophylline did not . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
21,
27
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
30,
37
]
} |
c-reactive protein and caeruloplasmin are demonstrated to be acute-phase reactants also in 6-sai arthritis , although on the whole the acute-phase reaction is relatively weak . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
0,
18
]
} | {
"id": "C0001347",
"name": "acute-phase reactants",
"pos": [
61,
82
]
} |
c-reactive protein and caeruloplasmin are demonstrated to be acute-phase reactants also in 6-sai arthritis , although on the whole the acute-phase reaction is relatively weak . | NA | {
"id": "C0007841",
"name": "caeruloplasmin",
"pos": [
23,
37
]
} | {
"id": "C0001347",
"name": "acute-phase reactants",
"pos": [
61,
82
]
} |
we studied the influence of vasoactive substances ( angiotensin ii , epinephrine , norepinephrine and acetylcholine ) on the synthesis of prostanoids in isolated rat glomeruli . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
69,
80
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
83,
97
]
} |
as irrigation water in israel originates from the various types of water that we found to be culture-positive for legionella , the public health implications of this finding were correlated with our previous seroepidemiological survey of irrigation workers . | NA | {
"id": "C0590256",
"name": "irrigation water",
"pos": [
3,
19
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
67,
72
]
} |
in 5 patients ( 3 of 18 with cutaneous t-cell lymphomas , 2 of 5 with lymphomatoid papulosis ) partial remission could be achieved . | NA | {
"id": "C0079773",
"name": "cutaneous",
"pos": [
29,
38
]
} | {
"id": "C0206182",
"name": "lymphomatoid papulosis",
"pos": [
70,
92
]
} |
successful development of radiopharmaceuticals from monoclonal antibodies will require the control of several immunochemical aspects of the antibody molecules . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
52,
73
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
140,
148
]
} |
biodistribution data were obtained for four monoclonal antibodies by first modifying each antibody at its carbohydrate with a diethylenetriaminepentaacetic acid ( dtpa ) derivative . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
44,
65
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
90,
98
]
} |
heterologous antibodies that attach to tumor-associated antigens present on tumor cell surfaces and which are then identified by radiolabeled antibodies directed against the species in which the original , unlabeled antibody was made , and radiolabeled compounds injected regionally at the tumor site . | NA | {
"id": "C0003248",
"name": "heterologous antibodies",
"pos": [
0,
23
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
216,
224
]
} |
furthermore , it was shown that the ototoxic aminoglycoside gentamicin has a selective and extremely high binding affinity to pip2 . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
45,
59
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
60,
70
]
} |
of the 45 cell samples tested , 29 were fresh peripheral blood mononuclear ( pbm ) cells while 15 were cryopreserved pbm . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
10,
14
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear",
"pos": [
46,
74
]
} |
in this study , we demonstrate that the antigens defined by the a1g3 and a3d8 antibodies reside on the same protein and represent closely related but nonidentical epitopes on the p80 molecule . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
40,
48
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
163,
171
]
} |
a monoclonal anti-il-2 receptor ( r ) antibody ( moab ) , tu69 , which blocked lp responses of il 2-dependent t-cell lines , also blocked sc induction by t-cell clones , but completely failed to inhibit sc generation in mlc or with il-2 . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
38,
46
]
} | {
"id": "C0003250",
"name": "moab",
"pos": [
49,
53
]
} |
one patient experienced complete regression of her bilateral carotid body tumors over the ensuing 2.5 years and the other 3 patients have had no evidence of disease progression of their chemodectomas for 2 , 3 , and 4.5 years , respectively . | NA | {
"id": "C0007279",
"name": "of",
"pos": [
44,
46
]
} | {
"id": "C0030422",
"name": "chemodectomas",
"pos": [
186,
199
]
} |
susceptibility of hsv strains from patients with genital herpes treated with various formulations of acyclovir . | NA | {
"id": "C0019348",
"name": "hsv",
"pos": [
18,
21
]
} | {
"id": "C0019342",
"name": "genital herpes",
"pos": [
49,
63
]
} |
twenty-five cylindrical specimens of veins , obtained from 20 cadavers several hours after death , were mounted in a pulsatile flow system with a pulse rate of 80/min and a mean flow rate of 7 ml/min at various perfusion pressures . | NA | {
"id": "C0006629",
"name": "cadavers",
"pos": [
62,
70
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
91,
96
]
} |
abdominal aortic aneurysms : distribution of elastin , collagen i and iii , and intermediate filament proteins desmin and vimentin -- a comparison of familial and nonfamilial aneurysms . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
80,
110
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
122,
130
]
} |
the aortic walls of patients with abdominal aortic aneurysms ( aaa ) and of healthy controls were examined for elastin , collagen i and iii , and the intermediate filament proteins desmin and vimentin by immunohistochemical , enzyme histochemical , and routine histological techniques . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
150,
180
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
192,
200
]
} |
polyvalent cation-induced membrane aggregation was reversibly suppressed by high ionic strength as well as by metal ion chelators , irreversibly inhibited by the cross-linking agent glutaraldehyde , and enhanced by increasing concentrations of ethanol and increased temperature of the medium . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
11,
17
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
236,
239
]
} |
taken together , these results suggest that the precursor cells of hair cortex and nail plate share a major pathway of epithelial differentiation , and that the acidic 44k/46k and basic 56-60k hard keratins represent a co-expressed keratin pair which can serve as a marker for hair/nail-type epithelial differentiation . | NA | {
"id": "C1179973",
"name": "basic",
"pos": [
180,
185
]
} | {
"id": "C0010803",
"name": "keratin",
"pos": [
232,
239
]
} |
fibroblastic bhk cells spread readily on fl3 , a 75-kd fragment representing the rgds-containing , `` '' cell-binding '' '' domain of fibronectin , but b16-f10 melanoma cells could not . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
0,
12
]
} | {
"id": "C0007634",
"name": "a cel",
"pos": [
167,
172
]
} |
the effect of serum was nonspecific since serum could be replaced by equivalent concentrations of serum albumin , ovalbumin , or gamma globulins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
104,
111
]
} | {
"id": "C0029923",
"name": "ovalbumin",
"pos": [
114,
123
]
} |
however , the phosphotyrosine content of vinculin in these cells was unchanged from that of control , untreated rsv-cef despite the change in morphology . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
59,
64
]
} | {
"id": "C0016030",
"name": "cef",
"pos": [
116,
119
]
} |
we suggest that the actin in spread fibroblasts polymerizes predominantly at the cell edges and then moves centripetally , forming the microfilament sheath and bundles . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
36,
47
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
81,
85
]
} |
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