text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in all systems examined , the troponin t crossreactive components were located in regions or on structures of possible ca2+ or calmodulin activity , suggesting a possible functional similarity to troponin t . | NA | {
"id": "C0077404",
"name": "troponin t",
"pos": [
30,
40
]
} | {
"id": "C0041199",
"name": "troponin",
"pos": [
196,
204
]
} |
the most common malocclusions are cross bite , large maxillary overjet , distal molar occlusion , and a tendency to open bite . | NA | {
"id": "C0024636",
"name": "malocclusions",
"pos": [
16,
29
]
} | {
"id": "C0266061",
"name": "open bite",
"pos": [
116,
125
]
} |
the phorbol ester 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) , at nanomolar concentrations , induces rapid ( t1/2 approximately 30 s ) protrusion of multiple petal-shaped lamellae by neutrophil leucocytes . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
4,
17
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol-13-acetate",
"pos": [
18,
55
]
} |
positive tumour cells were found in two of 11 squamous cell carcinomas , one of 11 adenocarcinomas , 10 of 10 oat cell carcinomas , 11 of 11 carcinoid tumours , 16 of 20 malignant melanomas , four of seven clear cell sarcomas , nine of 25 leiomyosarcomas , four of 22 rhabdomyosarcomas , one of seven angiosarcomas and o... | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
83,
98
]
} | {
"id": "C0007095",
"name": "carcinoid tumours",
"pos": [
141,
158
]
} |
subsequently , some of the identified cortical and thalamic target areas were injected with retrograde tracers such as wheat germ-agglutinin conjugated with horseradish peroxidase ( wga-hrp ) or with a fluorescent tracer -- fast blue or nuclear yellow -- in order to disclose the laminar origin of the parahippocampal ef... | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
157,
179
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
182,
189
]
} |
injections of anterogradely transported tritiated amino acids and the retrograde tracers hrp , wga-hrp , fast blue , or nuclear yellow were placed within the limits of the parahippocampal cortex . | NA | {
"id": "C0019941",
"name": "hrp",
"pos": [
89,
92
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
95,
102
]
} |
the ultrastructural characteristics of hrp-wga-labeled or degenerating axon terminals arising from neurons in the dorsal column nuclei ( dcn ) were identified within the contralateral basilar pontine nuclei ( bpn ) following unilateral hrp-wga injections or ablations of the dcn . | NA | {
"id": "C0078473",
"name": "hrp-wga",
"pos": [
39,
46
]
} | {
"id": "C0019941",
"name": "hrp",
"pos": [
236,
239
]
} |
these data indicate that noradrenaline-synthesizing neurons are primarily found in the caudal vlm and in the region near the superior olivary nucleus , whereas catecholamine neurons in the rostral vlm between these two noradrenergic cell groups synthesize adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
25,
38
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
256,
266
]
} |
the ascending projections of cholinergic neurons in the laterodorsal tegmental nucleus ( tld ) were investigated in the rat by using phaseolus vulgaris leucoagglutinin ( pha-l ) and wheat germ agglutinin-conjugated horseradish peroxidase ( wga-hrp ) anterograde tracing techniques . | NA | {
"id": "C0019941",
"name": "horseradish",
"pos": [
215,
226
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
240,
247
]
} |
differences in tissue staining pattern and immunoglobulin class suggest a heterogeneity of antigenic specificity among the antibodies . | NA | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
43,
63
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
123,
133
]
} |
the sequence of rupture of the uterus -- -- shock -- -- pathological condition of coagulation -- -- great increase in the shock occurred in all three patients . | NA | {
"id": "C0030660",
"name": "pathological condition",
"pos": [
56,
78
]
} | {
"id": "C0036974",
"name": "shock",
"pos": [
122,
127
]
} |
an immunocytochemical staining technique was used to localize four fragments [ pro gamma msh , gamma msh , acth and beta endorphin/beta lipotrophin ( beta endorphin/beta lph ) ] of the proopiomelanocortin molecule in both the adult and fetal sheep pituitary . | NA | {
"id": "C0023832",
"name": "beta",
"pos": [
116,
120
]
} | {
"id": "C0033195",
"name": "proopiomelanocortin",
"pos": [
185,
204
]
} |
both adult-type and fetal proopiomelanocortin cells were identified in serial sections of the fetal anterior pituitary , stained with anti-pro gamma msh , anti-acth and anti-beta endorphin/beta lph . | NA | {
"id": "C0033195",
"name": "proopiomelanocortin",
"pos": [
26,
45
]
} | {
"id": "C0023832",
"name": "beta",
"pos": [
189,
193
]
} |
differences in distal nephron chloride , potassium and bicarbonate reabsorption among the groups support the hypothesis that the enhanced distal sodium reabsorption in the newborn occurred largely in the ascending loop of henle with nacl expansion , while it occurred in the late distal and cortical collecting tubules w... | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
30,
38
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
233,
237
]
} |
differences in distal nephron chloride , potassium and bicarbonate reabsorption among the groups support the hypothesis that the enhanced distal sodium reabsorption in the newborn occurred largely in the ascending loop of henle with nacl expansion , while it occurred in the late distal and cortical collecting tubules w... | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
55,
66
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
324,
330
]
} |
although no truly aminoglycoside-resistant isolates were found , some isolates of prov . stuartii and prov . rettgeri had mic 's higher than the other isolates to gentamicin and netilmicin , suggesting the presence of low levels of the enzyme aac 2 ' . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
18,
32
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
163,
173
]
} |
some adjuvants , such as muramyl dipeptide ( mdp ) analog formulations , preferentially induce the formation of antibodies of isotypes that interact with complement and antibody-dependent effector cells , and do not elicit reaginic antibodies . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
169,
177
]
} | {
"id": "C0034761",
"name": "reaginic",
"pos": [
223,
231
]
} |
however , given several monoclonal antibodies reactive with the same antigen , most investigators have found that only a few antibodies are useful for solid-phase immunoaffinity antigen purification . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
24,
34
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
125,
135
]
} |
kinetic considerations also dictated il-2 adsorption to mixtures of two or more monoclonal antibodies : il-2 immunoadsorption correlated with the association rates of the individual antibodies , rather than the equilibrium binding constants . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
80,
101
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
182,
192
]
} |
in addition , the results obtained indicate that monoclonal antibodies may differ markedly as regards their kinetic binding characteristics , and that all antibodies can serve as effective immunoadsorbents , provided their antigen binding characteristics are known . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
49,
70
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
155,
165
]
} |
inhibitory effect of bis [ 2- ( e-2-alkenoylaminoethyl ] disulfides and 2- ( e-octenoylamino ) ethyl carbamoylmethyl sulfides on carrageenin-induced paw edema in rats . | NA | {
"id": "C0012771",
"name": "disulfides",
"pos": [
57,
67
]
} | {
"id": "C0038739",
"name": "sulfides",
"pos": [
117,
125
]
} |
effects of the opioid peptides [ met5 ] enkephalin-arg6-phe7 and [ met5 ] enkephalin-arg6-gly7-leu8 on cholinergic neurotransmission in the rabbit isolated atria . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
15,
30
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
74,
84
]
} |
the effect of the opioid peptides [ met5 ] enkephalin-arg6-phe7 ( meap ) and [ met5 ] enkephalin-arg6-gly7-leu8 ( meagl ) were compared with those of [ leu5 ] enkephalin and [ d-ala2 , met5 ] enkephalinamide ( dame ) on cholinergic neurotransmission in the rabbit isolated atria . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
18,
33
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
192,
202
]
} |
dexamethasone treatment ( 3 mg/kg week for three weeks ) induced a decrease of 35s-sulphate incorporation in cartilage and ultrastructural changes of articular chondrocytes , mainly characterized by an increase in cell mortality rate , a decrease in length of endoplasmic reticulum , in the number of golgi bodies and in... | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
160,
172
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
214,
218
]
} |
a patient with diffuse osteosclerosis consistent with 'benign ' osteopetrosis had skeletal scintiscan findings indistinguishable from bilateral avascular necrosis of the femoral heads . | NA | {
"id": "C0029464",
"name": "osteosclerosis",
"pos": [
23,
37
]
} | {
"id": "C0029454",
"name": "osteopetrosis",
"pos": [
64,
77
]
} |
the symptoms of this so-called 'first-use syndrome ' may range from severe urticaria and angioedema to life-threatening bronchospasm , hypotension , and cardiopulmonary collapse . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
75,
84
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
89,
99
]
} |
the cholesterol lowering atherosclerosis study ( clas ) is a prospective , placebo-controlled , angiographic trial designed to test the hypothesis that aggressive lowering of ldl cholesterol with concomitant increase in hdl cholesterol will reverse or retard the atherosclerotic process . | NA | {
"id": "C0008377",
"name": "clas",
"pos": [
49,
53
]
} | {
"id": "C0023824",
"name": "ldl cholesterol",
"pos": [
175,
190
]
} |
these associations suggest that the isolation and sequencing of the apob and the apoa-i/c-iii/a-iv genes from different individuals will give useful information about how changes in the dna sequence of these genes may lead to alterations in the levels of their respective apolipoproteins , in the level of the lipoprotei... | NA | {
"id": "C0003593",
"name": "apob",
"pos": [
68,
72
]
} | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
272,
287
]
} |
studies of dna polymorphisms at apolipoprotein loci have uncovered associations with lipid levels and genetic linkage between dna polymorphisms at the apolipoprotein b ( apob ) locus and the ag ( x ) antigenic polymorphism of low density lipoprotein . | NA | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
32,
46
]
} | {
"id": "C0003593",
"name": "apolipoprotein b",
"pos": [
151,
167
]
} |
patients with non-insulin-dependent diabetes mellitus ( niddm ; type 2 ) make up a more heterogeneous group than those with iddm and it is likely that in these patients similar clinical phenotypes may be produced by different genetic defects . | NA | {
"id": "C0011849",
"name": "non-insulin-dependent diabetes",
"pos": [
14,
44
]
} | {
"id": "C0011860",
"name": "niddm",
"pos": [
56,
61
]
} |
the synthesis of either an abnormal insulin/proinsulin molecule or an abnormal insulin receptor can confer susceptibility to niddm . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
36,
43
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
44,
54
]
} |
this may explain the observed significant effects of the apoe alleles on the phenotypic variance of plasma lipoprotein concentrations in different ethnic groups and , moreover , the involvement of apoe alleles in the pathogenesis of multifactorial forms of hyperlipidaemia , for example , hypertriglyceridaemia , familia... | NA | {
"id": "C0003595",
"name": "apoe",
"pos": [
57,
61
]
} | {
"id": "C0052198",
"name": "apoe-2",
"pos": [
349,
355
]
} |
this may explain the observed significant effects of the apoe alleles on the phenotypic variance of plasma lipoprotein concentrations in different ethnic groups and , moreover , the involvement of apoe alleles in the pathogenesis of multifactorial forms of hyperlipidaemia , for example , hypertriglyceridaemia , familia... | NA | {
"id": "C0003595",
"name": "apoe",
"pos": [
57,
61
]
} | {
"id": "C0052201",
"name": "apoe-4",
"pos": [
414,
420
]
} |
this may explain the observed significant effects of the apoe alleles on the phenotypic variance of plasma lipoprotein concentrations in different ethnic groups and , moreover , the involvement of apoe alleles in the pathogenesis of multifactorial forms of hyperlipidaemia , for example , hypertriglyceridaemia , familia... | NA | {
"id": "C0020473",
"name": "hyperlipidaemia",
"pos": [
257,
272
]
} | {
"id": "C0020557",
"name": "hypertriglyceridaemia",
"pos": [
289,
310
]
} |
the lp ( a ) glycoprotein exhibits genetic polymorphism which is controlled by a series of autosomal alleles at a single locus and which is associated with lipoprotein concentrations in plasma . | NA | {
"id": "C0065058",
"name": "lp ( a",
"pos": [
4,
10
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
156,
167
]
} |
quantitative measures of plasma apolipoproteins , lipoproteins and lipids are examples of phenotypes that link genetic and environmental factors to the chd end-point . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
35,
47
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
67,
73
]
} |
this 'measured genotype ' approach may be used to study the genetic architecture ( number of loci involved , the frequencies and effects of their alleles , and the type of loci , i.e. , structural or regulatory ) of quantitative variation in the plasma apolipoproteins , lipoproteins and lipids . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
256,
268
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
288,
294
]
} |
this paper reviews statistical models , sampling designs and results of studies designed to estimate the genetic architecture of selected apolipoproteins , lipoproteins and lipids . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
141,
153
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
173,
179
]
} |
the acute antihypertensive effects of the dihydropyridine calcium antagonist , felodipine , were investigated in 12 male patients aged 43 to 64 years with uncontrolled blood pressure on combined treatment with a thiazide diuretic , a beta-blocker and hydralazine . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonist",
"pos": [
42,
76
]
} | {
"id": "C0015772",
"name": "felodipine",
"pos": [
79,
89
]
} |
antihypertensive and biochemical effects of the dihydropyridine felodipine in the long term treatment of moderate to severe hypertension . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
48,
63
]
} | {
"id": "C0015772",
"name": "felodipine",
"pos": [
64,
74
]
} |
felodipine is a new dihydropyridine calcium antagonist drug with cardiovascular effects , whose pharmacokinetics and effects on plasma digoxin levels have been studied in patients with left ventricular failure . | NA | {
"id": "C0015772",
"name": "felodipine",
"pos": [
0,
10
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonist",
"pos": [
20,
54
]
} |
felodipine is a dihydropyridine calcium antagonist which has a positive inotropic effect in the dog in vivo . | NA | {
"id": "C0015772",
"name": "felodipine",
"pos": [
0,
10
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonist",
"pos": [
16,
50
]
} |
the results indicate either that surface glycoconjugates in ht29 cells are dominated by glycolipid , or that the labelled glycoproteins are more or less free to diffuse in the plane of the membrane . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
41,
56
]
} | {
"id": "C0017950",
"name": "glycolipid",
"pos": [
88,
98
]
} |
the results indicate either that surface glycoconjugates in ht29 cells are dominated by glycolipid , or that the labelled glycoproteins are more or less free to diffuse in the plane of the membrane . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
41,
56
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
122,
135
]
} |
we have co-transformed carrot ( daucus carota ) and arabidopsis thaliana with an agrobacterium tumefaciens non-tumorigenic t-dna carrying the maize transposable element activator ( ac ) and an agrobacterium rhizogenes ri t-dna . | NA | {
"id": "C0012868",
"name": "transposable",
"pos": [
148,
160
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
223,
226
]
} |
c-reactive protein ( crp ) is a major acute phase reactant in man but not in mouse . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
0,
18
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
38,
58
]
} |
processing is slowed , leading to 35s rna accumulation and most cleavage occurs , not at the normal sites , but at sites which in wild-type strains are used for subsequent steps in rrna maturation . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
38,
41
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
181,
185
]
} |
these data are consistent with the synthesis of pyridine derivatives from glutaraldehyde-amine precursors in which the last step is an irreversible oxidation of dihydropyridines to pyridines . | NA | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
161,
177
]
} | {
"id": "C0034255",
"name": "pyridines",
"pos": [
181,
190
]
} |
each type of proteoglycan is preferentially associated with one connective tissue component : ( a ) a dermatan sulfate proteoglycan interacts with collagenous fibers , ( b ) a heparan sulfate proteoglycan is associated with elastic fibers and with the exterior surface of the basement membrane-like layer surrounding smo... | NA | {
"id": "C0033692",
"name": "proteoglycan",
"pos": [
13,
25
]
} | {
"id": "C0033689",
"name": "chondroitin sulfate proteoglycan",
"pos": [
351,
383
]
} |
substituting drinking water with 2 % alpha difluoromethylornithine ( alpha-dfmo ) commencing 48 hr prior to partial hepatectomy and continuing until death , though ineffective in inhibition of liver [ 3h ] -thymidine incorporation , prevented the rise in hepatic putrescine concentrations ( without modifying those of sp... | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
263,
273
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
406,
412
]
} |
substituting drinking water with 2 % alpha difluoromethylornithine ( alpha-dfmo ) commencing 48 hr prior to partial hepatectomy and continuing until death , though ineffective in inhibition of liver [ 3h ] -thymidine incorporation , prevented the rise in hepatic putrescine concentrations ( without modifying those of sp... | NA | {
"id": "C0037874",
"name": "spermine",
"pos": [
333,
341
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
406,
412
]
} |
verapamil , lignocaine , procainamide , propranolol , 40 h-propranolol , megx , and napa all caused an increase in the free fraction of gallopamil in serum . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
0,
9
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
136,
146
]
} |
the apparent km of the enzyme for gastric mucus glycoprotein was 10.5 microm , and the sulfate ester was found incorporated into the carbohydrate chains of mucin . | NA | {
"id": "C0017135",
"name": "gastric mucus glycoprotein",
"pos": [
34,
60
]
} | {
"id": "C0026682",
"name": "mucin",
"pos": [
156,
161
]
} |
although the protein synthesis of the cells was reduced in the serum-independent medium , they were still able to produce a variety of proteins such as transferrin ( tf ) and fibronectin ( fn ) in addition to alpha-fetoprotein ( afp ) and albumin ( alb ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
13,
20
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
239,
246
]
} |
when heat-killed propionibacterium acnes ( p. acnes ) and a small amount of endotoxin lipopolysaccharide ( lps ) were intravenously injected into mice at a week 's interval , most of them died of massive hepatic cell necrosis . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
76,
85
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
86,
104
]
} |
uncapped messenger rnas ( mrnas ) encoding calf preprochymosin , chicken prelysozyme , or escherichia coli beta-glucuronidase ( gus ) were synthesized in vitro , with or without a 5'-terminal 67-nucleotide sequence ( omega ' ) derived from the untranslated 5'-leader ( omega ) of tobacco mosaic virus ( tmv ) rna . | NA | {
"id": "C0035696",
"name": "messenger rnas",
"pos": [
9,
23
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
309,
312
]
} |
its nucleotide sequence codes for the beta-lactoglobulin a , from amino acid residues leu-11 to ile-162 , as based on the amino acid sequence reported by braunitzer et al . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
66,
76
]
} | {
"id": "C0301714",
"name": "based",
"pos": [
109,
114
]
} |
iap ( islet-activating protein , pertussis toxin ) is capable of uncoupling the receptor stimulation to activation of ni and/or n0 , thus resulting in the inhibition of negative inotropic and chronotropic responses to muscarinic receptor agonists , and to adenosine and its derivatives such as n6-phenylisopropyladenosin... | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
256,
265
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
297,
321
]
} |
the systemic and coronary hemodynamic actions of a newly synthesized inotropic agent structurally related to milrinone and amrinone , mci-154 ( 0.5-4.0 micrograms/kg/min iv ) , were studied in 2 groups of conscious , chronically instrumented dogs with normal or depressed postischemic , reperfused myocardium after a 15-... | NA | {
"id": "C0128513",
"name": "milrinone",
"pos": [
109,
118
]
} | {
"id": "C0002697",
"name": "amrinone",
"pos": [
123,
131
]
} |
crf acts within the brain to increase plasma concentrations of adrenaline and noradrenaline resulting in increased plasma concentrations of glucagon and in hyperglycemia . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
63,
73
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
78,
91
]
} |
the acth-producing microadenoma is by far the most common cause of hypercortisolism in patients with cushing 's syndrome . | NA | {
"id": "C0001622",
"name": "hypercortisolism",
"pos": [
67,
83
]
} | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
101,
120
]
} |
in order to determine the molecular mechanisms by which thyroid hormone and other factors regulate the biosynthesis of thyrotropin ( tsh ) , we have isolated and characterized the gene encoding the beta-subunit of rat tsh . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
119,
130
]
} | {
"id": "C0076641",
"name": "beta-subunit",
"pos": [
198,
210
]
} |
both the molecular weight ( 29,000 mw ) , and the fact that hsf activity was not inhibited by an antiserum directed against murine interleukin-1 alpha ( il-1 alpha ) , suggests that hsf and il-1 are distinct cytokines . | NA | {
"id": "C0600251",
"name": "interleukin-1 alpha",
"pos": [
131,
150
]
} | {
"id": "C0021755",
"name": "il-1",
"pos": [
190,
194
]
} |
this interleukin , il-6 , is a growth and differentiation factor for b cells as well as for t cells ; | NA | {
"id": "C0021764",
"name": "interleukin",
"pos": [
5,
16
]
} | {
"id": "C0021760",
"name": "il-6",
"pos": [
19,
23
]
} |
this interleukin , il-6 , is a growth and differentiation factor for b cells as well as for t cells ; | NA | {
"id": "C0021764",
"name": "interleukin",
"pos": [
5,
16
]
} | {
"id": "C0021758",
"name": "growth",
"pos": [
31,
37
]
} |
in vitro , il-1 induces increased synthesis of a number of lymphokines ( il-2 , il-3 , il-4 and il-6 ) , a variety of colony stimulating factors , and endothelial factors leading to clot formation and vascular congestion . | NA | {
"id": "C0021757",
"name": "il-3",
"pos": [
80,
84
]
} | {
"id": "C0009392",
"name": "colony stimulating factors",
"pos": [
118,
144
]
} |
experiments were designed to compare the tumour-inhibitory effect of highly purified ril-2 with that of unpurified human and rat lymphoid interleukin-2 ( il-2 ) preparations . | NA | {
"id": "C0218986",
"name": "ril-2",
"pos": [
85,
90
]
} | {
"id": "C0021756",
"name": "interleukin-2",
"pos": [
138,
151
]
} |
immunomodulating peptides include glycopeptides from the bacterial cell wall , natural acyloligopeptide ciclosporin , peptidic hormones from the thytide cyclosporine , peptidic hormones from the thymus , peptidic fragments of immunoglobulins and other plasma proteins , as well as peptides isolated from food proteins . | NA | {
"id": "C0030935",
"name": "peptidic fragments",
"pos": [
204,
222
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
281,
289
]
} |
genetic parameters were estimated for birth weight and weaning weight from records collected on 1,894 santa gertrudis calves ( 939 bulls , 955 heifers ) during the 8-yr period , 1978 through 1985 . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
38,
50
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
63,
69
]
} |
heritability estimates calculated across sexes were .32 +/- .07 and .42 +/- .08 for birth weight and weaning weight , respectively . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
84,
96
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
109,
115
]
} |
estimates of genetic and phenotypic correlations of birth weight and weaning weight by sex were .43 +/- .21 and .31 , respectively , for bulls and .33 +/- .22 and .27 , respectively , for heifers . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
52,
64
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
77,
83
]
} |
seventy-two 3-mo-old pastel mink were fed diets that contained 0 , 33 , 60 , 108 , 194 or 350 ppm supplemental fluorine ( f ) , as naf , for 382 d to assess its effects on growth , fur quality , reproduction and survivability . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
38,
39
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
131,
134
]
} |
and second , from the hemispherical cells to spread cells in which f-actin bundles ran radially or in parallel to each other through the leading lamella from a cytocentre to the edges , as in fibroblastic cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
36,
41
]
} | {
"id": "C0016030",
"name": "fibroblastic cells",
"pos": [
192,
210
]
} |
these , and other carboxylic acids , were also detected as ester moieties of alkaloidal impurities in illicit cocaine as well as in alkaloids of the south american coca leaf , e.g. , alpha- and beta-truxilline . | NA | {
"id": "C0007066",
"name": "carboxylic acids",
"pos": [
18,
34
]
} | {
"id": "C0014898",
"name": "ester",
"pos": [
59,
64
]
} |
the microscope is focused on an in-line quartz flow cell incorporated down stream of a microbore hplc column or directly on an optically clear portion of fused-silica capillary columns for analyte detection . | NA | {
"id": "C0034387",
"name": "quartz",
"pos": [
40,
46
]
} | {
"id": "C0037098",
"name": "silica",
"pos": [
160,
166
]
} |
the new resin is a quadridentate chelate former and specially suitable for metal ions with coordination numbers of six , since two valencies remain for the reversible binding of biopolymers . | NA | {
"id": "C0035191",
"name": "resin",
"pos": [
8,
13
]
} | {
"id": "C0005554",
"name": "biopolymers",
"pos": [
178,
189
]
} |
the tert.-butyldimethylsilyl ( t-bdms ) derivatives of the hydroxyl and the carboxyl groups on the monohydroxyeicosatetraenoic acids ( hetes ) 5- , 12- and 15-hydroxyeicosatetraenoic acid ( 5-hete , 12-hete and 15-hete , respectively ) as well as leukotriene b4 ( ltb4 ) , 20-carboxy-ltb4 ( 20-cooh-ltb4 ) and 20-hydroxy... | NA | {
"id": "C0020349",
"name": "hydroxyeicosatetraenoic acid",
"pos": [
103,
131
]
} | {
"id": "C0044800",
"name": "12-hete",
"pos": [
199,
206
]
} |
quantification of riboflavin , riboflavin 5'-phosphate and flavin adenine dinucleotide in plasma and urine by high-performance liquid chromatography . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
18,
28
]
} | {
"id": "C0016388",
"name": "riboflavin 5",
"pos": [
31,
43
]
} |
a high-performance liquid chromatographic method with fluorimetric detection for the quantification of riboflavin ( rb ) , riboflavin 5'-phosphate ( fmn ) , and flavin adenine dinucleotide ( fad ) in plasma , whole blood , and urine is described . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
103,
113
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
149,
152
]
} |
methylhydrazine , benzylhydrazine , phenelzine and pheniprazine each yielded single derivatives with this procedure suggesting that the analytical procedure has a broad application to the analysis of other monoalkylated hydrazines . | NA | {
"id": "C0031392",
"name": "phenelzine",
"pos": [
36,
46
]
} | {
"id": "C0020233",
"name": "hydrazines",
"pos": [
220,
230
]
} |
the method was applied to monitor whole blood levels of phenelzine in rats treated intravenously with phenelzine sulphate . | NA | {
"id": "C0031392",
"name": "phenelzine",
"pos": [
56,
66
]
} | {
"id": "C0031393",
"name": "phenelzine sulphate",
"pos": [
102,
121
]
} |
the carboxylic acid compounds are converted to their methyl esters and the hydroxylated metabolites to their o-trifluoroacetates prior to analysis by capillary gas chromatography using nitrogen-selective detection . | NA | {
"id": "C0007066",
"name": "carboxylic acid",
"pos": [
4,
19
]
} | {
"id": "C0014898",
"name": "esters",
"pos": [
60,
66
]
} |
pepsin treatment has the additional advantage of inactivating antibodies and so releasing the ag from immune complexes . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
62,
72
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
102,
118
]
} |
however , it is found that any salt level in the sample feed ( already at 1 mm concentration ) deteriorates transport of non-isoelectric proteins , because of the much larger current fraction carried by the ions themselves as opposed to proteins . | NA | {
"id": "C0007292",
"name": "transport",
"pos": [
108,
117
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
237,
245
]
} |
fetal plasma norepinephrine and epinephrine concentrations increased significantly at all levels of hypoxaemia , but dopamine increased only at very low fetal oxygen tensions . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
13,
27
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
32,
43
]
} |
relatively more severe hypoxaemia was necessary to elevate concentrations of epinephrine above baseline as compared with norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
77,
88
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
121,
135
]
} |
a negative exponential correlation ( p less than 0.001 ) was found between both fetal arterial po2 and oxygen content and plasma norepinephrine and epinephrine , which was qualitatively similar to that observed previously in the sheep fetus . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
129,
143
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
148,
159
]
} |
in the 5 fetuses that died during the recovery period adrenal blood flow failed to increase and , at the nadir of asphyxia , peripheral vessels dilated and central vessels constricted . | NA | {
"id": "C0011065",
"name": "died",
"pos": [
22,
26
]
} | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
114,
122
]
} |
plasma gonadotrophin concentrations , pituitary gonadotrophin content and pituitary responsiveness to lhrh in rats treated with lhrh and oestradiol benzoate . | NA | {
"id": "C0018061",
"name": "gonadotrophin",
"pos": [
7,
20
]
} | {
"id": "C0018066",
"name": "pituitary gonadotrophin",
"pos": [
38,
61
]
} |
following the ntd classification used by koch ( 1984 ) , our case series consisted of anencephalus 50.3 % , spina bifida 44.2 % , and ntd with other system defects 5.5 % . | NA | {
"id": "C0002902",
"name": "anencephalus",
"pos": [
86,
98
]
} | {
"id": "C0027794",
"name": "ntd",
"pos": [
134,
137
]
} |
following the ntd classification used by koch ( 1984 ) , our case series consisted of anencephalus 50.3 % , spina bifida 44.2 % , and ntd with other system defects 5.5 % . | NA | {
"id": "C0080178",
"name": "spina bifida",
"pos": [
108,
120
]
} | {
"id": "C0027794",
"name": "ntd",
"pos": [
134,
137
]
} |
in liver cirrhosis , the four acute phase reactants , alpha 1-antiproteinase , orosomucoid , and haptoglobin and caeruloplasmin , showed a pattern in serum , in which alpha 1-antiproteinase was increased , orosomucoid and haptoglobin were decreased , and caeruloplasmin was normal . | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
30,
51
]
} | {
"id": "C0002191",
"name": "alpha",
"pos": [
167,
172
]
} |
in liver cirrhosis , the four acute phase reactants , alpha 1-antiproteinase , orosomucoid , and haptoglobin and caeruloplasmin , showed a pattern in serum , in which alpha 1-antiproteinase was increased , orosomucoid and haptoglobin were decreased , and caeruloplasmin was normal . | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
30,
51
]
} | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
206,
217
]
} |
in liver cirrhosis , the four acute phase reactants , alpha 1-antiproteinase , orosomucoid , and haptoglobin and caeruloplasmin , showed a pattern in serum , in which alpha 1-antiproteinase was increased , orosomucoid and haptoglobin were decreased , and caeruloplasmin was normal . | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
30,
51
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
222,
233
]
} |
in liver cirrhosis , the four acute phase reactants , alpha 1-antiproteinase , orosomucoid , and haptoglobin and caeruloplasmin , showed a pattern in serum , in which alpha 1-antiproteinase was increased , orosomucoid and haptoglobin were decreased , and caeruloplasmin was normal . | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
30,
51
]
} | {
"id": "C0007841",
"name": "caeruloplasmin",
"pos": [
255,
269
]
} |
two modifications of lowry 's procedure ( markwell 's and kresze 's ) were investigated for interference by zwitterionic buffers ) ( hepes , hepps , pipes , mes , mops , ches , caps , tris , glycylglycine , bicine ) , detergents ( triton-x-100 , digitonin ) , sugars ( sucrose , mannitol , sorbitol ) , salts ( nacl , kc... | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
260,
266
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
269,
276
]
} |
this effect of cb-154 on body weight may be a result of some as yet unidentified effect of dopaminergic stimulation on overall growth since 1 ) these changes in body weight were not reflected as changes in lipid mass , as occurs naturally following short-day exposure for each species , and 2 ) neither species exhibited... | NA | {
"id": "C0005910",
"name": "body weight",
"pos": [
25,
36
]
} | {
"id": "C0005911",
"name": "change in",
"pos": [
334,
343
]
} |
plasmid- and chromosomal-dna-mediated transformation events were competitive , magnesium-dependent , 42 degrees c-sensitive processes specific to double-stranded dna , suggesting a common mechanism of dna binding and uptake . | NA | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
146,
165
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
220,
221
]
} |
pseudomonas aeruginosa region ii alginate genes are involved in the biosynthesis of the uronic acid containing exopolysaccharide , alginic acid . | NA | {
"id": "C0102137",
"name": "genes",
"pos": [
42,
47
]
} | {
"id": "C0051156",
"name": "alginic acid",
"pos": [
131,
143
]
} |
basal levels of urinary norepinephrine ( ne ) and epinephrine ( e ) excretion of aged vitamin e-deficient rats was 2- to 3-fold higher than those of control rats . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
24,
38
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
50,
61
]
} |
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