text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
comparative effects of choline chloride and phosphatidylcholine on plasma and liver lipid levels in rats fed a choline-deficient high cholesterol diet . | NA | {
"id": "C0008409",
"name": "choline chloride",
"pos": [
23,
39
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
111,
118
]
} |
the effects of dietary choline chloride and phosphatidylcholine ( pc ) on plasma and liver lipid levels were investigated with rats fed a choline-deficient high cholesterol diet . | NA | {
"id": "C0008409",
"name": "choline chloride",
"pos": [
23,
39
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
138,
145
]
} |
the addition of pc to the choline-free diet also resulted in an increase in the plasma cholesterol level , but the magnitude of the increase was significantly lower than that by choline chloride . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
26,
33
]
} | {
"id": "C0008409",
"name": "choline",
"pos": [
178,
185
]
} |
the results indicate that the plasma cholesterol level , but not triglyceride , is differentially influenced by dietary choline chloride and pc , and that pc has both hyper- and antihypercholesterolemic effects when compared with a choline-free diet and a diet supplemented with choline chloride , respectively . | NA | {
"id": "C0008409",
"name": "choline chloride",
"pos": [
120,
136
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
279,
286
]
} |
when these fractions were incubated with purified human albumin and separated again on the sephadex g25 , a large immunoreactive peak corresponding to albumin was again found while the immunoreactivity after salt completely disappeared . | NA | {
"id": "C0304925",
"name": "human albumin",
"pos": [
50,
63
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
151,
158
]
} |
norepinephrine , epinephrine and vanilmandelic acid were significantly increased ( p less than 0.01 ) during work-shifts in the group exposed to 90 db ( a ) , compared with baseline levels and also with catecholamine levels in the group exposed to 78 db ( a ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
17,
28
]
} |
the long-term efficacy of isradipine , a new dihydropyridine calcium antagonist with marked vascular selectivity , was evaluated in 17 patients with essential hypertension . | NA | {
"id": "C0071304",
"name": "isradipine",
"pos": [
26,
36
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonist",
"pos": [
45,
79
]
} |
we studied the haemodynamic ( systemic and renal ) and humoral effects of nicardipine , a dihydropyridine calcium entry blocker in essential hypertensives and whether da2 dopaminergic receptor blockade , induced by domperidone , might modify these effects . | NA | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
74,
85
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
90,
105
]
} |
low-dose angiotensin ii ( ang ii ) infusion raised plasma atrial natriuretic peptide ( anp ) levels only when endogenous renin-angiotensin levels were low , as in aldosterone-producing adenoma . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
9,
23
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
127,
138
]
} |
caffeine or theophylline derivatives ( 0.1-4 mm ) , during exposure to drug , produced effects similar to those observed after the application of ibmx ; | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
12,
24
]
} | {
"id": "C0000096",
"name": "ibmx",
"pos": [
146,
150
]
} |
adenosine ( 10-100 microm ) or 2-chloroadenosine ( 1-10 microm ) had no effect on the time constant of e.p.c . decay nor did these adenosine receptor agonists alter the post-junctional actions of ibmx . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
0,
9
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
31,
48
]
} |
the order of effectiveness of the anions studied in inhibiting the ca2+-dependent release was glutamate less than br- = cl- = i- less than scn- . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
34,
40
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
126,
127
]
} |
cytochemical comparison of the effect of hydrocortisone and normal development on the appearance of a mixture of sucrase , maltase , isomaltase and trehalase disaccharidases ( alpha-glucosidase activity ) shows this enzyme to appear first in enterocytes at the base of the villus . | NA | {
"id": "C0038634",
"name": "sucrase",
"pos": [
113,
120
]
} | {
"id": "C0012610",
"name": "disaccharidases",
"pos": [
158,
173
]
} |
cytochemical comparison of the effect of hydrocortisone and normal development on the appearance of a mixture of sucrase , maltase , isomaltase and trehalase disaccharidases ( alpha-glucosidase activity ) shows this enzyme to appear first in enterocytes at the base of the villus . | NA | {
"id": "C0040814",
"name": "trehalase",
"pos": [
148,
157
]
} | {
"id": "C0012610",
"name": "disaccharidases",
"pos": [
158,
173
]
} |
the adrenaline released in response to histamine at 3 mg/kg was exclusively of adrenal origin whereas the noradrenaline released was of non-adrenal origin ( most probably noradrenergic sympathetic nerves ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
4,
14
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
106,
119
]
} |
k+-atp channel activity was stimulated by adenosine 5'-diphosphate ( adp ) , guanosine 5'-triphosphate ( gtp ) , guanosine 5'-diphosphate ( gdp ) , guanosine 5'-o- ( 3-thiotriphosphate ) ( gtp gamma s ) and guanosine 5'-o- ( 2-thiodiphosphate ) ( gdp beta s ) when millimolar mg2+ bathed the internal surface of the patc... | NA | {
"id": "C0079469",
"name": "guanosine",
"pos": [
77,
86
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
189,
192
]
} |
when external sodium ions were partially replaced by guanidinium ions , the fast inactivating current was preferentially reduced and was absent in a solution containing guanidinium ions as the only external permeant cations . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
21,
25
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
216,
223
]
} |
whereas the slow inactivating current could be carried by guanidinium ions , these cations were not only impermeant through the sodium channels which give rise to the fast inactivating current but also blocked this type of channel with an apparent dissociation constant of 49 mm . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
70,
74
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
83,
90
]
} |
the dihydropyridine antagonist nifedipine ( 10 microm ) inhibits l current ( approximately 60 % block ) at a holding potential that inactivates half the l-type channels . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
4,
19
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
31,
41
]
} |
nifedipine , a dhp ca2+ antagonist , strongly inhibits l-type channel activity through an increase in the proportion of blank sweeps . | NA | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
0,
10
]
} | {
"id": "C0012315",
"name": "dhp",
"pos": [
15,
18
]
} |
pre-incubation ( 1-5 min ) with 12-o-tetradecanoylphorbol-13-acetate ( tpa , 8-16 nm ) , a tumour-promoting phorbol ester known to activate protein kinase c , was found to inhibit acetylcholine-induced ca2+-dependent k+ and cl- currents in cells isolated from rat lacrimal glands . | NA | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
32,
68
]
} | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
108,
121
]
} |
in experiments in which the extracellular na+ concentration was varied the extended constant-field equation was adequate in predicting shifts of the nmda reversal potential recorded on varying [ na+ ] o over the range 50-150 mm , but failed to accurately predict the reversal potential of responses to nmda with 10 mm- [... | NA | {
"id": "C0949755",
"name": "nmda",
"pos": [
149,
153
]
} | {
"id": "C0004015",
"name": "nmda",
"pos": [
302,
306
]
} |
practical ion yield variations were compared by three different approaches : ( i ) by the use of cells doped with known electrolyte concentrations , ( ii ) by quantitative ion implantation , and ( iii ) by analysis of the same cell with both electron probe and ion microscope . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
120,
131
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
261,
264
]
} |
antimicrobial activities of sulbactam/cefoperazone ( sbt/cpz ) against 50 fresh clinical isolates of staphylococcus aureus , escherichia coli , klebsiella pneumoniae , citrobacter freundii , enterobacter spp. , serratia marcescens , proteus mirabilis , proteus vulgaris and pseudomonas aeruginosa were compared to those ... | NA | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
329,
337
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
348,
358
]
} |
comparative antimicrobial activities indicated by mic80 's of tested agents showed that sbt/cpz had more stable activities against bacteria ranging from gram-positive to gram-negative bacteria than ctm , ctx and lmox . | NA | {
"id": "C0007556",
"name": "ctm",
"pos": [
198,
201
]
} | {
"id": "C0007554",
"name": "ctx",
"pos": [
204,
207
]
} |
efficacy of fmox in 6 patients with infectious diseases including 2 cases with pneumonia , 3 cases with acute exacerbation by respiratory infection , 1 case with obstructive pneumonia were clinically evaluated . | NA | {
"id": "C0009450",
"name": "infectious diseases",
"pos": [
36,
55
]
} | {
"id": "C0035243",
"name": "respiratory infection",
"pos": [
126,
147
]
} |
antimicrobial activities of sisomicin ( siso ) against clinical isolates obtained in the second half of 1986 were investigated together with other 4 aminoglycosides ( ags ) ( gentamicin ( gm ) , tobramycin ( tob ) , dibekacin ( dkb ) , amikacin ( amk ] and 2 cephems ( cefotiam , cefotaxime ) , and were compared to the ... | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
28,
37
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
175,
185
]
} |
antimicrobial activities of sisomicin ( siso ) against clinical isolates obtained in the second half of 1986 were investigated together with other 4 aminoglycosides ( ags ) ( gentamicin ( gm ) , tobramycin ( tob ) , dibekacin ( dkb ) , amikacin ( amk ] and 2 cephems ( cefotiam , cefotaxime ) , and were compared to the ... | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
149,
164
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
175,
185
]
} |
antimicrobial activities of sisomicin ( siso ) against clinical isolates obtained in the second half of 1986 were investigated together with other 4 aminoglycosides ( ags ) ( gentamicin ( gm ) , tobramycin ( tob ) , dibekacin ( dkb ) , amikacin ( amk ] and 2 cephems ( cefotiam , cefotaxime ) , and were compared to the ... | NA | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
269,
277
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
280,
290
]
} |
refering to an american study reporting that the genus providencia including p. rettgeri showed high incidence of resistance to siso as well as to gm or tob , we pointed out that the antimicrobial activity of ags against genus providencia should be evaluated separately from those of other indole ( + ) proteus strains . | NA | {
"id": "C0037209",
"name": "siso",
"pos": [
128,
132
]
} | {
"id": "C0017436",
"name": "gm",
"pos": [
147,
149
]
} |
refering to an american study reporting that the genus providencia including p. rettgeri showed high incidence of resistance to siso as well as to gm or tob , we pointed out that the antimicrobial activity of ags against genus providencia should be evaluated separately from those of other indole ( + ) proteus strains . | NA | {
"id": "C0017436",
"name": "gm",
"pos": [
147,
149
]
} | {
"id": "C0002556",
"name": "ags",
"pos": [
209,
212
]
} |
methicillin-resistant staphylococcus aureus ( mrsa ) were isolated from samples collected from various patients during 1986 , and antibacterial activities of 6 aminoglycosides ( ags ) ( netilmicin ( ntl ) , gentamicin ( gm ) , sisomicin ( siso ) , dibekacin ( dkb ) , tobramycin ( tob ) and amikacin ( amk ] and 4 beta-l... | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
160,
175
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
207,
217
]
} |
methicillin-resistant staphylococcus aureus ( mrsa ) were isolated from samples collected from various patients during 1986 , and antibacterial activities of 6 aminoglycosides ( ags ) ( netilmicin ( ntl ) , gentamicin ( gm ) , sisomicin ( siso ) , dibekacin ( dkb ) , tobramycin ( tob ) and amikacin ( amk ] and 4 beta-l... | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
186,
196
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
227,
236
]
} |
methicillin-resistant staphylococcus aureus ( mrsa ) were isolated from samples collected from various patients during 1986 , and antibacterial activities of 6 aminoglycosides ( ags ) ( netilmicin ( ntl ) , gentamicin ( gm ) , sisomicin ( siso ) , dibekacin ( dkb ) , tobramycin ( tob ) and amikacin ( amk ] and 4 beta-l... | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
207,
217
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
227,
236
]
} |
antibacterial activities of gm , siso , dkb and tob were weak , and mic50 's of gm and dkb were both 100 micrograms/ml , while those of siso and tob were 50 and greater than 100 micrograms/ml , respectively . | NA | {
"id": "C0017436",
"name": "gm",
"pos": [
28,
30
]
} | {
"id": "C0037209",
"name": "siso",
"pos": [
136,
140
]
} |
regional effects of intracoronary administration of nicardipine , a dihydropyridine derivative with calcium blocking activity , were studied in 13 open-chest dogs . | NA | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
52,
63
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
68,
83
]
} |
[ changes in plasma lipoprotein in patients with alcoholic liver diseases . ( i ) . composition of lipids in each lipoproteins ] . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
99,
105
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
114,
126
]
} |
effects of morphine microinjected into the hypothalamic supraoptic ( son ) and paraventricular ( pvn ) nuclei , which contain neurons producing and releasing antidiuretic hormone ( vasopressin ) , on the outflow and the osmotic pressure of urine and other visceral functions were investigated in a rat which was loaded w... | NA | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
158,
178
]
} | {
"id": "C0003779",
"name": "vasopressin",
"pos": [
181,
192
]
} |
tachykinin antagonist i : specific , competitive and tissue-selective neurokinin b antagonists on contractile activity in smooth muscles . | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
0,
10
]
} | {
"id": "C0027847",
"name": "neurokinin b",
"pos": [
70,
82
]
} |
a study of 20 patients with essential hypertension , stage iib , asymmetrical myocardial hypertrophy and chest pains has suggested that the pain syndrome , presenting as `` '' possible angina '' '' , positive functional tests and reduced label accumulation around the ventricular septum may be indicative of coronary ins... | NA | {
"id": "C0008031",
"name": "chest pains",
"pos": [
105,
116
]
} | {
"id": "C0002962",
"name": "angin",
"pos": [
185,
190
]
} |
a theory is presented that describes the free energy difference between the enzyme-substrate ( es ) and enzyme-product ( ep ) complexes that is expected in enzymes optimized for catalytic efficiency . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
76,
82
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
156,
163
]
} |
in such enzymes , the free energy drop between es and ep complexes reflects a portion of the chemical potential difference between substrates and products outside the active site under physiological conditions . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
8,
15
]
} | {
"id": "C0026741",
"name": "ep complexes",
"pos": [
54,
66
]
} |
alkyl lysophospholipids ( alp ) are synthetic analogues of lysophosphatidylcholine and represent a new generation of antitumor drugs currently being tested in phase-i trials in patients with cancer . | NA | {
"id": "C0024367",
"name": "lysophospholipids",
"pos": [
6,
23
]
} | {
"id": "C0024360",
"name": "lysophosphatidylcholine",
"pos": [
59,
82
]
} |
it is demonstrated that he-pc is well-absorbed from the intestinal tract , intravenous ( iv ) and oral administration lead to similar distributions throughout the body , the highest accumulation of radioactivity occurs in liver , lung and kidney , and the metabolic products are radioactive choline , phosphocholine and ... | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
291,
298
]
} | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
301,
315
]
} |
seventeen mycotoxins [ aflatoxins b1 ( afb1 ) , b2 ( afb2 ) , g1 ( afg1 ) , g2 ( afg2 ) , aflatoxicol , sterigmatocystin , patulin , citrinin , penicillic acid , t-2 toxin , diacetoxyscirpenol , zearalenone , zearalenol ( alpha and beta isomers 1:1 ) , ochratoxin a , norsolorinic acid , averufin , versicolorin a ] were... | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
10,
20
]
} | {
"id": "C0038274",
"name": "sterigmatocystin",
"pos": [
104,
120
]
} |
seventeen mycotoxins [ aflatoxins b1 ( afb1 ) , b2 ( afb2 ) , g1 ( afg1 ) , g2 ( afg2 ) , aflatoxicol , sterigmatocystin , patulin , citrinin , penicillic acid , t-2 toxin , diacetoxyscirpenol , zearalenone , zearalenol ( alpha and beta isomers 1:1 ) , ochratoxin a , norsolorinic acid , averufin , versicolorin a ] were... | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
10,
20
]
} | {
"id": "C0030710",
"name": "patulin",
"pos": [
123,
130
]
} |
six of the mycotoxins ( afb1 , afg1 , afb2 , aflatoxicol , sterigmatocystin and versicolorin a ) were genotoxic on pq37 strain with and without metabolic activation . | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
11,
21
]
} | {
"id": "C0038274",
"name": "sterigmatocystin",
"pos": [
59,
75
]
} |
substantially similar responses to veratridine plus ouabain were obtained after loading with 3h-noradrenaline , 3h-adrenaline or 3h-dopamine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
96,
109
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
115,
125
]
} |
the rank order of potency of several kinin analogues on the pain response was bk much much greater than sigma-cyclo- ( lys1-gly6 ) -bk = sigma-cyclo-kallidin greater than des-arg9-bk . | NA | {
"id": "C0022474",
"name": "kallidin",
"pos": [
149,
157
]
} | {
"id": "C0006100",
"name": "bk",
"pos": [
180,
182
]
} |
the clinical pre-operative examination shows that many signs and symptoms are associated : volitional and postural dyskinesia , athetosis and dystonia , pyramidal deficit and spasticity . | NA | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
115,
125
]
} | {
"id": "C0004158",
"name": "athetosis",
"pos": [
128,
137
]
} |
twenty-two children had various other seizure-like disorders , particularly tics , febrile convulsions , pavor nocturnus and fainting , and three had absence attacks . | NA | {
"id": "C0014544",
"name": "seizure",
"pos": [
38,
45
]
} | {
"id": "C0009952",
"name": "febrile",
"pos": [
83,
90
]
} |
intracranial pressure rise caused a sympathetic system response with increased arterial blood pressure , increased heart rate and various arrhythmias , even ventricular fibrillation . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
138,
149
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
157,
181
]
} |
[ clinico-biochemical criteria of the effectiveness of using bone matrix in treating ununited fractures and pseudarthroses of the long bones ] . | NA | {
"id": "C0016665",
"name": "ununited fractures",
"pos": [
85,
103
]
} | {
"id": "C0033785",
"name": "pseudarthroses",
"pos": [
108,
122
]
} |
benign melanocytic naevi were found less often in association with hutchinson 's melanotic freckle ( melanoma ) ( 6 % ) and nodular melanoma ( 9 % ) than with superficial spreading melanoma ( 22 % ) or melanoma of unclassifiable type ( 34 % ) . | NA | {
"id": "C0149722",
"name": "hutchinson 's melanotic freckle",
"pos": [
67,
98
]
} | {
"id": "C0025202",
"name": "type",
"pos": [
229,
233
]
} |
transient idiopathic alkaline hyperphosphatasemia is a syndrome of unknown etiology unrelated to any specific disease , characterized by a marked transient increase of the serum level of alkaline phosphatase . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
55,
63
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
110,
117
]
} |
one should be aware of eye involvement in hydroa vacciniforme , and children who experience this form of photodermatitis should have a careful eye examination and be advised to wear protective sunglasses . | NA | {
"id": "C0020241",
"name": "hydroa vacciniforme",
"pos": [
42,
61
]
} | {
"id": "C0031762",
"name": "photodermatitis",
"pos": [
105,
120
]
} |
a case is described where resolution of the pancytopenia occurred but a persisting haematological disease remained . | NA | {
"id": "C0030312",
"name": "pancytopenia",
"pos": [
44,
56
]
} | {
"id": "C0018939",
"name": "haematological disease",
"pos": [
83,
105
]
} |
this case supports the observation that when chronic renal failure occurs in patients with tuberous sclerosis , cystic renal disease ( with or without hamartomas ) is more likely to be the underlying cause , rather than hamartomas alone . | NA | {
"id": "C0041341",
"name": "tuberous sclerosis",
"pos": [
91,
109
]
} | {
"id": "C0018552",
"name": "hamartomas",
"pos": [
220,
230
]
} |
in-hospital prognosis was better in patients with chronic or unstable angina than in patients without angina ( p less than 0.05 ) . | NA | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
61,
76
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
102,
108
]
} |
the findings of asymmetrical atrophy of pelvic limb extensor muscles , asymmetrical paresis of the limbs , a left : right dominance ratio of 50:50 , spontaneous rotational behaviour , decreased response to levodopa loading , and decreased levels of da ( 19 per cent reduction ) and dopac ( 30 per cent reduction ) in the... | NA | {
"id": "C0013030",
"name": "da",
"pos": [
249,
251
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
408,
420
]
} |
subsequent examination led to the diagnosis of an idiopathic megacolon whereas a congenital as well as symptomatic and toxic megacolon could be excluded . | NA | {
"id": "C0025160",
"name": "idiopathic megacolon",
"pos": [
50,
70
]
} | {
"id": "C0025162",
"name": "toxic megacolon",
"pos": [
119,
134
]
} |
in the literature it had been shown that patients with complications from this operation had decreased prekallikrein and increased kallikrein activity ( m . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
103,
116
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
131,
141
]
} |
we compared in six patients successively treated with an unfractionated heparin ( ufh ) and a low molecular weight heparin ( lmwh ) the variations in plasma anti-xa activity , measured in a chromogenic assay , during a 36 h constant infusion . | NA | {
"id": "C0019134",
"name": "unfractionated heparin",
"pos": [
57,
79
]
} | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
157,
164
]
} |
the assay system for factor xia was not significantly affected by the presence of plasma kallikrein , factor xiia , high-molecular-weight kininogen , amylose sulfate or sulfatide within the range of the amounts used for surface-mediated activation of factor xii , prekallikrein and factor xi . | NA | {
"id": "C0015524",
"name": "factor xia",
"pos": [
21,
31
]
} | {
"id": "C0015522",
"name": "factor xi",
"pos": [
282,
291
]
} |
the assay system for factor xia was not significantly affected by the presence of plasma kallikrein , factor xiia , high-molecular-weight kininogen , amylose sulfate or sulfatide within the range of the amounts used for surface-mediated activation of factor xii , prekallikrein and factor xi . | NA | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
102,
113
]
} | {
"id": "C0015525",
"name": "factor xii",
"pos": [
251,
261
]
} |
following surface-mediated activation of factor xi , further generation of factor xia was blocked by adding freeze-thawed platelets that contain cationic proteins which bind to negatively-charged surfaces ( j. biochem . 97 , 139-151 , 1985 ) . | NA | {
"id": "C0015522",
"name": "factor xi",
"pos": [
41,
50
]
} | {
"id": "C0015524",
"name": "factor xia",
"pos": [
75,
85
]
} |
cells from all patients responded to both homologous and heterologous antigens and the magnitude of the responses did not differ for any of the patient groups or antigens . | NA | {
"id": "C0003333",
"name": "heterologous antigens",
"pos": [
57,
78
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
162,
170
]
} |
8 proteins ( albumin , igg , igm , iga , c3c , c4 , orosomucoid and alpha 1 antitrypsin ) were determined by laser immunonephelometry in hydatid cyst fluid from cysts and sera from 16 patients . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
2,
10
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
13,
20
]
} |
the lack of a relationship between epstein-barr virus infection and burkitt 's lymphoma , nasopharyngeal carcinoma , malaria as well as liver diseases is briefly discussed . | NA | {
"id": "C0149678",
"name": "epstein-barr virus infection",
"pos": [
35,
63
]
} | {
"id": "C0006413",
"name": "burkitt 's lymphoma",
"pos": [
68,
87
]
} |
using limited resources , 17 physician hours per family until the child reached the age of seven years , a total of 120 mca/mr children ( 52 infants with down 's syndrome ) were treated between 1975 and 1984 . | NA | {
"id": "C0000772",
"name": "mca/mr",
"pos": [
120,
126
]
} | {
"id": "C0013080",
"name": "down 's syndrome",
"pos": [
154,
170
]
} |
traced were the periods of substitution of the fetal haemoglobin with adult in new-born lambs , and the influence of the liberated with the milk nitrates , taken by the sucking lambs , on the quantity of the methemoglobin . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
53,
64
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
208,
221
]
} |
myopia , as characterized by a large refractive error ( e.g . -10.7 +/- 0.4 d ) , was induced in post-hatch chicks by a 14 day application of a goggle that was designed to blur the retinal image . | NA | {
"id": "C0027092",
"name": "myopia",
"pos": [
0,
6
]
} | {
"id": "C0034951",
"name": "refractive error",
"pos": [
37,
53
]
} |
thus the lens neither contributes to , nor compensates for the large refractive error observed in experimentally induced myopia . | NA | {
"id": "C0034951",
"name": "refractive error",
"pos": [
69,
85
]
} | {
"id": "C0027092",
"name": "myopia",
"pos": [
121,
127
]
} |
equilibration patterns of barbiturates adsorption on activated charcoals were studied using aqueous solutions of barbital and sodium barbital and commercially available charcoals bau , ar-3 , ar-b , ar-a , skt-6a . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
26,
38
]
} | {
"id": "C0004743",
"name": "barbital",
"pos": [
133,
141
]
} |
equilibration patterns of barbiturates adsorption on activated charcoals were studied using aqueous solutions of barbital and sodium barbital and commercially available charcoals bau , ar-3 , ar-b , ar-a , skt-6a . | NA | {
"id": "C0001275",
"name": "activated charcoals",
"pos": [
53,
72
]
} | {
"id": "C0007955",
"name": "charcoals",
"pos": [
169,
178
]
} |
relatively low equilibrium concentrations of barbiturates in the solid phase and simultaneous sorption of the barbital anion as well as of its non-ionized form were related to the considerable rate of the substance ionization due to both tautomeric transformation and dissociation of the acid formed . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
45,
57
]
} | {
"id": "C0004743",
"name": "barbital",
"pos": [
110,
118
]
} |
the procedure for calculation of equilibrium described assumes that the rate of barbital and sodium barbital adsorption on activated charcoals of various brands might be estimated at various ph values of a solution , based on dissociation and hydrolysis reactions , which is of importance under conditions of the barbitu... | NA | {
"id": "C0004743",
"name": "barbital",
"pos": [
80,
88
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
313,
325
]
} |
on the molar ratio of 1:30 of human blood albumin and the bilirubin , bound with plasmatic membrane , shifting of ph within the ranges of ph 7.0-7.6 was followed by reverse binding of bilirubin with synaptosomal membranes ( ph 7.2 ) or with albumin ( ph 7.6 ) . | NA | {
"id": "C0304925",
"name": "human",
"pos": [
30,
35
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
241,
248
]
} |
its value in diagnosis of interstitial pulmonary diseases and other pulmonary diseases is described with special view to occupational expositions . | NA | {
"id": "C0206062",
"name": "interstitial pulmonary diseases",
"pos": [
26,
57
]
} | {
"id": "C0024115",
"name": "pulmonary diseases",
"pos": [
68,
86
]
} |
the complex study of phosphohydrolases ( mg2+atpase , na+ , k+atpase ) and adenylate cyclase in gonococci , both in vivo and in vitro , and in phagocytes in gonococcal infection has been carried out with the use of ultracytochemical techniques . | NA | {
"id": "C0001477",
"name": "mg2+atpase",
"pos": [
41,
51
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
62,
68
]
} |
all combinations with proteus vaccine , used in this investigation , stimulated the intensive formation of antibodies to proteus vaccine strain and re-glycolipid . | NA | {
"id": "C0206253",
"name": "combinations",
"pos": [
4,
16
]
} | {
"id": "C0042210",
"name": "vaccine",
"pos": [
129,
136
]
} |
retinoids , particularly tretinoin ( = retinoic acid ) and isotretinoin caused a pronounced inhibition of the chemiluminescence response only in primed neutrophils in vivo and in vitro , whereas etretinate and the metabolite ro 10-1670 was less inhibitory . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
0,
9
]
} | {
"id": "C0022265",
"name": "isotretinoin",
"pos": [
59,
71
]
} |
this result suggests that in hypertrophic scar a small number of fibroblasts proliferate more actively , but most fibroblasts are non-growing cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
65,
76
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
142,
147
]
} |
the mean nuclear volumes in the norepinephrine and epinephrine cells were enhanced significantly 4 h as well as 48 h after acute dcm intoxication . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
32,
46
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
51,
62
]
} |
the aim of this study was to investigate whether the c-reactive protein ( crp ) , another acute phase protein important in human medicine , is also influenced by adrenal hormones and if so whether the effects are receptor-mediated or not . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
53,
71
]
} | {
"id": "C0001347",
"name": "acute phase protein",
"pos": [
90,
109
]
} |
effects of sodium citrate , potassium citrate , and citric acid in preventing experimental calcium oxalate urolithiasis in rats . | NA | {
"id": "C0137996",
"name": "potassium citrate",
"pos": [
28,
45
]
} | {
"id": "C0055819",
"name": "citric acid",
"pos": [
52,
63
]
} |
nephrocalcinosis intermediate between those in the citrate groups and the glycolic-acid group , with some urinary calculi , was observed in the citric-acid group . | NA | {
"id": "C0008857",
"name": "citrate",
"pos": [
51,
58
]
} | {
"id": "C0055819",
"name": "citric-acid",
"pos": [
144,
155
]
} |
during the experiment , the urinary oxalate concentration increased markedly and was higher in the citrate and citric-acid than in the glycolic-acid group . | NA | {
"id": "C0008857",
"name": "citrate",
"pos": [
99,
106
]
} | {
"id": "C0055819",
"name": "citric-acid",
"pos": [
111,
122
]
} |
the urinary citrate concentration was significantly higher in the citrate groups and lower in the citric acid and glycolic-acid groups . | NA | {
"id": "C0008857",
"name": "citrate",
"pos": [
12,
19
]
} | {
"id": "C0055819",
"name": "citric acid",
"pos": [
98,
109
]
} |
fat cells originating from fatty element of the tumor were mature type and obtained from all of three patients who had much typical lipomatous element in the tumor . | NA | {
"id": "C0023798",
"name": "fatty",
"pos": [
27,
32
]
} | {
"id": "C0206631",
"name": "lipomatous",
"pos": [
132,
142
]
} |
we report the case of 8 children ( whose ages ranged between 2 and 7 ) who consulted us because of urticaria , accompanied by angioedema in 5 of the cases . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
99,
108
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
126,
136
]
} |
the refractive error observed in experimentally-induced myopia in chicks appears to occur as a result of expansion of the vitreous chamber . | NA | {
"id": "C0034951",
"name": "refractive error",
"pos": [
4,
20
]
} | {
"id": "C0027092",
"name": "myopia",
"pos": [
56,
62
]
} |
our experience suggests that ethosuximide may be a valuable adjunctive treatment for epileptic falling spells that occur in the context of multiple seizure types . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
85,
94
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
148,
155
]
} |
pemphigus foliaceus antibodies and a monoclonal antibody to desmoglein i demonstrate stratified squamous epithelial-specific epitopes of desmosomes . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
20,
30
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
37,
56
]
} |
thus , to determine whether certain epitopes of dgi are tissue-restricted , we performed immunofluorescence studies on various monkey tissues with the following antibodies : a rabbit polyclonal antiserum against whole desmosomes , which demonstrated the desmosomes in all tissues tested ; | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
161,
171
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
194,
203
]
} |
these results indicate that there is tissue heterogeneity of desmosomes , and that epitopes on dgi defined by both pf antibodies and a monoclonal antibody are present only in stratified squamous epithelia . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
118,
128
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
135,
154
]
} |
the cellular location of the two proteins suggests that retinoic acid may be particularly involved in the later stages of germ cell differentiation , but retinol may be the form of vitamin a that the sertoli cell receives initially . | NA | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
56,
69
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
181,
190
]
} |
finally , since typical trichothiodystrophy has been reported in patients with siemens ' syndrome or with marviesco-sjogren syndrome , these two syndromes may perhaps also be classified in the same category , as borderline forms of the disease . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
145,
154
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
236,
243
]
} |
for therapy of gonococcal ophthalmia neonatorum , 1 % kanamycin eyedrops combined with a single intramuscular injection of kanamycin or a third generation cephalosporin ( ceftriaxone or cefotaxime ) were all effective regimens . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
171,
182
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
186,
196
]
} |
though peritonitis is a common complication in continuous ambulatory peritoneal dialysis ( capd ) , tuberculous peritonitis has been reported in only twelve capd patients in the world english literature to date . | NA | {
"id": "C0031154",
"name": "peritonitis",
"pos": [
7,
18
]
} | {
"id": "C0041325",
"name": "tuberculous peritonitis",
"pos": [
100,
123
]
} |
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