text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
among young children splenomegaly and malaria were less prevalent in mandinkas than in wollofs or fulas , suggesting that some genetic or environmental factors protect mandinka children from this infection . | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
6,
20
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
177,
185
]
} |
these findings suggest that part of the pressor response of high doses of angiotensin ii is caused by the liberation of endogenous noradrenaline from the sympathetic nerve endings , but not by that of adrenaline from the adrenal medulla . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
131,
144
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
201,
211
]
} |
isosorbide-2-nitrate ( is-2-n , ec50 = 0.75 mm ) was found to be more potent than the stereoisomeric isosorbide-5-nitrate . | NA | {
"id": "C0022251",
"name": "isosorbide",
"pos": [
0,
10
]
} | {
"id": "C0064079",
"name": "isosorbide-5-nitrate",
"pos": [
101,
121
]
} |
since organic nitrate-induced activation of guanylate cyclase may involve the formation of nitric oxide free radicals , it is conceivable that the differences in potency reflect a varying degree of nitric oxide release from each compound tested . | NA | {
"id": "C0016693",
"name": "free radicals",
"pos": [
104,
117
]
} | {
"id": "C0028128",
"name": "nitric oxide",
"pos": [
198,
210
]
} |
in addition , gla-p and growth hormone ( hgh ) were assayed in blood samples obtained every 20 minutes during sleep in 12 children with growth retardation . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
24,
38
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
41,
44
]
} |
it included a ) essential amino acids ( i.e . histidine , lysine , threonine , tryptophan ) , b ) arginine ( 1,000 mg/d ) , c ) alphaketoisovaleric 500 mg/d , alpha-ketoisocaproic ( 500 mg/d ) , alphaketobetamethylvaleric ( 500 mg/d ) , alphaketogammamethylthiobutyric ( 200 mg/d ) , betaphenylpyruvic ( 400 mg/d ) acids... | NA | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
16,
37
]
} | {
"id": "C0040005",
"name": "threonine",
"pos": [
67,
76
]
} |
the suppression of the pleyotypic effect of phorbol ester was observed when n2a cells were cocultured with 3t3 fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
80,
85
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
111,
122
]
} |
the ascertained values of protein synthesis -- 8.4 g/d/kg -- and protein decomposition -- 6.9 g/d/kg -- agree very well with those determined with 15n glycine as tracer amino acid . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
151,
158
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
169,
179
]
} |
lungs of 24 corpses of persons , died from non-pulmonary pathology ( control ) and lungs of 34 corpses of persons , died from congenital and acquired heart disease accompanied with pre- and postcapillary forms of the pulmonary circulation hypertension , have been investigated . | NA | {
"id": "C0006629",
"name": "corpses",
"pos": [
12,
19
]
} | {
"id": "C0011065",
"name": "died",
"pos": [
116,
120
]
} |
by means of certain biochemical methods contents of hormones ( corticosterone , adrenaline and noradrenaline ) have been estimated , as well as that of cholesterin and ascorbic acid in blood and adrenal tissues . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
80,
90
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
95,
108
]
} |
using a semiquantitative method they developed for assessing myocardial status from histochemical tests for dehydrogenases ( glutamate , isocitrate , lactate , succinate , beta-hydroxybutyrate nadh , or nadph dehydrogenases ) , the authors found that demonstration of granular diformazan in such tests is not associated ... | NA | {
"id": "C0027298",
"name": "nadph",
"pos": [
203,
208
]
} | {
"id": "C0030016",
"name": "dehydrogenases",
"pos": [
364,
378
]
} |
there were differences between periodontitis and control samples in the proportions of proline to serine ( p less than 0.01 ) and proline to glutamic acid and glutamine ( p less than 0.05 ) . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
141,
154
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
159,
168
]
} |
thirty-five patients had dermatoses attributable to sle ( mean 3.7 per patient ) and 58 had dermatoses which were not directly attributable to sle ( mean 2.1 per patient ) , highlighting the need for accurate diagnosis of skin rashes in sle patients . | NA | {
"id": "C0037274",
"name": "dermatoses",
"pos": [
25,
35
]
} | {
"id": "C0015230",
"name": "skin rashes",
"pos": [
222,
233
]
} |
10188 growth records ( performance up to weaning ) of 283 largewhite pigs were used to estimate various components of variance using a mixed linear model for the birth weight , litter size at birth , weaning weight , and litter size at weaning . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
162,
174
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
208,
214
]
} |
this preference was maintained even when substrate phospholipid was solubilized in non-ionic , anionic , cationic and zwitterionic amphiphiles . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
87,
92
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
95,
102
]
} |
this preference was maintained even when substrate phospholipid was solubilized in non-ionic , anionic , cationic and zwitterionic amphiphiles . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
87,
92
]
} | {
"id": "C0007447",
"name": "cationic",
"pos": [
105,
113
]
} |
the terminal oxygenase component of benzene dioxygenase from pseudomonas putida strain ml2 was shown to contain two subunits , of mr 54,500 and 23,500 , by sds/polyacrylamide-gel electrophoresis . | NA | {
"id": "C0030065",
"name": "oxygenase",
"pos": [
13,
22
]
} | {
"id": "C0599874",
"name": "dioxygenase",
"pos": [
44,
55
]
} |
fibrin assembly after fibrinopeptide a release in model systems and human plasma studied with magnetic birefringence . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
0,
6
]
} | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
22,
38
]
} |
magnetically induced birefringence was used to monitor fibrin polymerization after the release of the small negatively charged a fibrinopeptides from human fibrinogen by the action of the snake-venom-derived enzymes reptilase and ancrod . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
55,
61
]
} | {
"id": "C0016022",
"name": "a fibrinopeptides",
"pos": [
127,
144
]
} |
epitope analysis of the 27 antibodies using liver alkaline phosphatase as antigen gave rise to six groupings , with four antibodies unclassified . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
0,
7
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
74,
81
]
} |
rh glycoproteins are not present in rh immune complexes as a result of non-specific adsorption of membrane glycoproteins during the membrane-solubilization phase of immune-complex isolation because rhd immune complexes isolated from a 1:1 ( v/v ) mixture of acde/cde and ocde/cde red cells do not contain blood-group-a-a... | NA | {
"id": "C0025248",
"name": "membrane glycoproteins",
"pos": [
98,
120
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
326,
338
]
} |
the mr-95,000 protein bound poorly to wheat-germ-lectin-sepharose and was not precipitated by antisera specific for insulin and egf receptors . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
14,
21
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
49,
55
]
} |
the protein continued to exhibit serine and tyrosine phosphorylation on addition of [ gamma-32p ] atp , mgcl2 and mncl2 to a glycoprotein-depleted fraction prepared by chromatography on wheat-germ-lectin-sepharose . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
197,
203
]
} |
the deformation of brain in the subdural hematoma type model was that corresponding to the hematoma of crescent shape just as seen on the ct scan of actual case . | NA | {
"id": "C0018946",
"name": "subdural hematoma",
"pos": [
32,
49
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
91,
99
]
} |
a case of sphenoidal ridge meningioma complicating chronic subdural hematoma and a case of malignant astrocytoma producing not only intracerebral hematoma but also acute subdural hematoma were reported , and the mechanism of subdural hematoma formation was discussed according to the literature . | NA | {
"id": "C0749095",
"name": "chronic subdural hematoma",
"pos": [
51,
76
]
} | {
"id": "C0018946",
"name": "subdural",
"pos": [
225,
233
]
} |
a case of sphenoidal ridge meningioma complicating chronic subdural hematoma and a case of malignant astrocytoma producing not only intracerebral hematoma but also acute subdural hematoma were reported , and the mechanism of subdural hematoma formation was discussed according to the literature . | NA | {
"id": "C0749098",
"name": "acute subdural hematoma",
"pos": [
164,
187
]
} | {
"id": "C0018946",
"name": "subdural",
"pos": [
225,
233
]
} |
two mouse monoclonal antibodies ( mabs ) , 25.31 raised against an subunit epitope of lfa1 antigen and mol against an epitope of the complement receptor type 3 ( cr3 ) were used for investigating their effects on human polymorphonuclear ( pmn ) functions . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
91,
98
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
118,
125
]
} |
differences between cereals in true digestibility of amino acids were confined to higher values for n , aspartic acid , alanine and leucine in maize than in barley or wheat meals . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
53,
64
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
120,
127
]
} |
the mutant grew only in the presence of unsaturated fatty acid having at least one delta 9cis double bond , and its conidial fatty acid profile was influenced by the exogenous acid . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acid",
"pos": [
40,
62
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
125,
135
]
} |
the fractional turnover rates were calculated using the specific activities of intracellular free tyrosine and free uracil nucleotides ( precursors ) and those of protein bound tyrosine and 28s rrna bound uridine monophosphate ( products ) respectively . | NA | {
"id": "C0041921",
"name": "uracil nucleotides",
"pos": [
116,
134
]
} | {
"id": "C0042002",
"name": "uridine monophosphate",
"pos": [
205,
226
]
} |
the fractional rate of synthesis of proteins and rrna ( expressed as percentage per day ) increased from 24 % to 45 % for proteins and from 25 % to 34 % for rrna and peaked by day 2 . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
23,
32
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
122,
130
]
} |
these results suggest that the pre-existing ribosomal rna could be underutilized under control conditions and that the boosting of rna transcription , associated with that of protein translation , is a complementary process rather than a prerequisite for the transition period leading to hypertrophy . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
44,
57
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
131,
134
]
} |
felodipine is a dihydropyridine calcium antagonist that has a positive inotropic effect at low concentration in the dog in vivo . | NA | {
"id": "C0015772",
"name": "felodipine",
"pos": [
0,
10
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium",
"pos": [
16,
39
]
} |
three weeks after myocardial infarction , when left ventricular function was impaired , catecholamine responsiveness was determined by measuring the effects of isoprenaline in the conscious animal , the isolated perfused heart , the isolated right atria , and the right papillary muscles . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
88,
101
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
160,
172
]
} |
lipid microemulsions with various core and surface lipid compositions were prepared by co-sonication of cholesteryl esters , triolein ( to ) , egg phosphatidylcholine ( egg pc ) , and cholesterol . | NA | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
104,
122
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
184,
195
]
} |
the synthesis of cholesteryl esters by this enzyme was also insensitive to the ratios of cholesterol and egg pc in the microemulsion surface layers . | NA | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
17,
35
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
89,
100
]
} |
thrombin cleavage of apo c-iii produced two fragments : only fragment 41-79 retained the inhibitory activity and was equipotent to native apo c-iii1 on a molar basis . | NA | {
"id": "C0052191",
"name": "apo c-iii",
"pos": [
21,
30
]
} | {
"id": "C0003594",
"name": "apo c",
"pos": [
138,
143
]
} |
[ spontaneous hematoma syndrome of the abdominal rectus muscles ( differential diagnosis of acute abdomen and other diseases . personal cases ] . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
23,
31
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
116,
124
]
} |
whole complement ( ch50 ) , c3 , c4 , the alternate pathway activity of complement ( aph50 ) and factor b were measured in 159 women currently taking oral contraceptives and in 186 women who were not taking the pill . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
6,
16
]
} | {
"id": "C0033453",
"name": "factor b",
"pos": [
97,
105
]
} |
in this report , we use a monoclonal antibody ( b2c2 ) and antibodies against a fusion protein ( leaf et al . 1987 ) to characterize msp130 , a cell surface protein specific to the primary mesenchyme cells of the sea urchin embryo . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
26,
45
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
59,
69
]
} |
prazosin , an alpha 1 adrenergic antagonist , was given during the period of disease induction and blocked fluorescein leakage from actively inflamed retinal vessels , but had little effect on the clinical and pathological signs of disease . | NA | {
"id": "C0025345",
"name": "period",
"pos": [
67,
73
]
} | {
"id": "C0030660",
"name": "pathological",
"pos": [
210,
222
]
} |
in these studies involving healthy volunteers , type 1 ( insulin-dependent ) diabetic patients on continuous subcutaneous insulin infusion or intensified conventional insulin therapy and insulin treated type 2 ( non-insulin-dependent ) diabetic patients , no differences with regard to biological effects , counterregula... | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
57,
64
]
} | {
"id": "C0795635",
"name": "human insulin preparations",
"pos": [
432,
458
]
} |
the responses of plasma immunoreactive insulin , c-peptide , and immunoreactive glucagon to arginine infusion were investigated in nine healthy subjects after induction of hyperglycaemia by an oral glucose load and by intravenous glucose infusion to produce similar glucose concentrations in the arterialised blood . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
198,
205
]
} | {
"id": "C0005802",
"name": "glucose",
"pos": [
266,
273
]
} |
using this vector , mobilizable libraries of bacterial dna can be efficiently made without a need for size fractionation of target dna . | NA | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
45,
58
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
131,
134
]
} |
these data indicate that the fisher-344 rat is useful animal in which to study aminoglycoside ototoxicity as it exhibits both functional and morphological changes after gentamicin administration . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
79,
93
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
169,
179
]
} |
these findings suggest the possibility that the diuretic receptor in the kidney and the receptor mediating ototoxicity in the cochlea , may have similar steric requirements for interacting with loop diuretics . | NA | {
"id": "C0012798",
"name": "diuretic",
"pos": [
48,
56
]
} | {
"id": "C0354100",
"name": "loop diuretics",
"pos": [
194,
208
]
} |
epinephrine , phenylephrine , levonordefrin , felypressin , and norepinephrine have all been utilized in conjunction with the local anesthetics by the various medical professions . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
64,
78
]
} |
phosphoribosyltransferases , which convert adenine , guanine and hypoxanthine to the corresponding nucleoside monophosphates , and adenosine kinase were the major enzymes for purine scavenging in all mycobacteria studied . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
43,
50
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
175,
181
]
} |
the aaca-aphd aminoglycoside resistance determinant of the staphylococcus aureus transposon tn4001 , which specifies resistance to gentamicin , tobramycin and kanamycin , has been cloned and shown to express these resistances in escherichia coli . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
14,
28
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
131,
141
]
} |
nucleic acid isolated from purified phage was resistant to hydrolysis under alkaline conditions and to digestion with rnaase , but it was hydrolysed by dnaase , providing evidence that the phage genome is made up of dna . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
0,
12
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
216,
219
]
} |
these results demonstrated that all beta-lactam antibiotics have a common transport system with an organic anion such as probenecid , irrespective of their ionic charges , though a cationic charge on the molecule is less advantageous for being recognized by the carrier system . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
156,
161
]
} | {
"id": "C0007447",
"name": "cationic",
"pos": [
181,
189
]
} |
in eleven chronically catheterized fetal sheep aged 124-142 days , hypotension caused by infusion of sodium nitroprusside ( 1.6-3.3 mg/h ) and competitive antagonism of angiotensin ii by saralasin ( 3.3 mg/h ) both caused a fall in fetal urine flow ( p less than 0.02 and p less than 0.05 , respectively ) , and in sodiu... | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
169,
183
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
187,
196
]
} |
in both e.d.l . and soleus fibres , the dihydropyridine ( dhp ) , nifedipine , suppressed the calcium current entirely . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
40,
55
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
66,
76
]
} |
another dhp calcium antagonist , ( + ) pn200/110 , was indistinguishable from nifedipine in its effects of suppressing calcium currents and qns . | NA | {
"id": "C2945601",
"name": "dhp calcium antagonist",
"pos": [
8,
30
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
78,
88
]
} |
since baclofen is a gaba agonist , systems utilizing gaba and acting on gabab receptors appear to produce inhibitory control of velocity storage . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
6,
14
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
72,
76
]
} |
sixteen of the patients ( 94 % ) complained of acute symptoms including : burning of the eyes ( 82 % ) , excessive tearing ( 47 % ) , nasal burning ( 41 % ) , nasal itching ( 35 % ) , chest pain/tightness ( 35 % ) , rhinorhea ( 29 % ) , cough ( 29 % ) , dyspnea ( 29 % ) , burning of the throat ( 24 % ) , burning/prurit... | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
190,
194
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
364,
372
]
} |
consistency indices were calculated for previously published alpha crystallin a chain and myoglobin amino acid-sequence cladograms and for four original amino acid-sequence cladograms ( alpha crystallin a , myoglobin , and alpha and beta hemoglobin ) ; | NA | {
"id": "C0002202",
"name": "alpha crystallin a chain",
"pos": [
61,
85
]
} | {
"id": "C0002257",
"name": "alpha crystallin",
"pos": [
186,
202
]
} |
on the basis of mutual hybridization of single-strand dna fragments it was shown that all nicks are located in one of the phi kf77 dna chains . | NA | {
"id": "C0012935",
"name": "single-strand dna",
"pos": [
40,
57
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
131,
134
]
} |
antisera that are highly specific to the z-dna were produced : there is practically no interaction between the antisera and the native or denaturated dna and the b-form of poly [ d ( g-c ) ] .poly [ d ( g-c ) ] . | NA | {
"id": "C0043442",
"name": "z-dna",
"pos": [
41,
46
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
150,
153
]
} |
[ genetic engineering of peptide hormones . i. cloning and primary structure of cdna of chicken growth hormone ] . | NA | {
"id": "C0597192",
"name": "peptide hormones",
"pos": [
25,
41
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
103,
110
]
} |
[ identification of protein products of the operon for leukocytosis ( lymphocytosis ) -stimulating factor from bordetella pertussis cloned in escherichia coli ] . | NA | {
"id": "C0023518",
"name": "leukocytosis",
"pos": [
55,
67
]
} | {
"id": "C0024282",
"name": "lymphocytosis",
"pos": [
70,
83
]
} |
flupirtine fulfilled the requirements of both patients and doctors for effective cancer pain relief e.g . maintenance of the quality of life by complete or nearly complete pain remission in association with lack of abuse potential , oral dosage form and lack of disturbance of vital functions . | NA | {
"id": "C0596240",
"name": "cancer pain",
"pos": [
81,
92
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
172,
176
]
} |
an additional 415 patients received positive control medications ( paracetamol 650 mg , codeine 60 mg , pentazocine 50 mg or oxycodone 10 mg plus paracetamol 650 mg ) . | NA | {
"id": "C0009214",
"name": "codeine",
"pos": [
88,
95
]
} | {
"id": "C0030049",
"name": "oxycodone",
"pos": [
125,
134
]
} |
here we present evidence for the presence of a single hemopexin domain in an interstitial collagenase and in a collagenase homolog , as well as of two copies of the domain in vitronectin . | NA | {
"id": "C0127082",
"name": "interstitial collagenase",
"pos": [
77,
101
]
} | {
"id": "C0162745",
"name": "collagenase",
"pos": [
111,
122
]
} |
we have compared the ph dependencies of the rate constants for the dissociation and combination of the fourth carbon monoxide molecule , l4 and l ' 4 , respectively , for native hemoglobin a ( hba ) and a control reconstituted hba , and des- ( arg 141 alpha ) hba , the hemoglobin molecule resulting from the enzymatic r... | NA | {
"id": "C0019016",
"name": "hba",
"pos": [
193,
196
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
382,
384
]
} |
[ evaluation of the indicators of arteriosclerosis risk factors : cholesterol : hdl cholesterol and ldl cholesterol : hdl cholesterol in acute and chronic diseases of the liver ] . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
66,
77
]
} | {
"id": "C0023822",
"name": "hdl",
"pos": [
118,
121
]
} |
[ evaluation of the indicators of arteriosclerosis risk factors : cholesterol : hdl cholesterol and ldl cholesterol : hdl cholesterol in acute and chronic diseases of the liver ] . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
66,
77
]
} | {
"id": "C0023824",
"name": "ldl cholesterol",
"pos": [
100,
115
]
} |
similarity of the morphological picture of gouty nephropathy and primary glomerulonephritides in which purine antagonists turned out to be effective , a positive effect of azathioprine ( az ) and 6-mercaptopurine ( mp ) on purine metabolism , and changes in immunity indices revealed in gout ( hyperproduction of immunog... | NA | {
"id": "C0004482",
"name": "azathioprine",
"pos": [
172,
184
]
} | {
"id": "C0000618",
"name": "purine",
"pos": [
223,
229
]
} |
strict control over az and mp therapy makes side-effects of the drugs rare , and they can be easily done away with after reducing a drug dose . | NA | {
"id": "C0004482",
"name": "az",
"pos": [
20,
22
]
} | {
"id": "C0000618",
"name": "therapy",
"pos": [
30,
37
]
} |
the levels of immunoglobulins and other proteins ( alpha 2-mg , alpha 1-at , c3 , albumin , transferrin and lactoferrin ) were studied in the bal of 60 patients with different types of pulmonary tuberculosis , 4 patients with sarcoidosis and 7 cnpd patients . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
40,
48
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
82,
89
]
} |
this strain contains the 23.5 kb penicillinase plasmid , determining beta-lactamase synthesis and resistance to heavy metal salts , and a larger plasmid greater than 100 kb in size , which was detectable only in coagulase positive variants . | NA | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
33,
46
]
} | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
69,
83
]
} |
serotype o6/o14 : h12 ) yielded nonmucoid ( = sm 29-nm ) variants that had lost most of the o6/o14 o-antigen ( lps ) and all of the sm 29-m k-antigen extract reactivity ( elisa test ) and which were ca . | NA | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
99,
108
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
111,
114
]
} |
removal of fluorescence could be accomplished in toto by adsorption onto activated charcoal with subsequent recovery from charcoal by treatment with sodium hydroxide , ph 12 ( ex 380 nm : 51.1 % , ex 400 nm : 91.8 % ) . | NA | {
"id": "C0001275",
"name": "activated charcoal",
"pos": [
73,
91
]
} | {
"id": "C0007955",
"name": "charcoal",
"pos": [
122,
130
]
} |
in autosomal chromosomopathies , a robertsonian translocation was seen between chromosomes 13 and 14 , a reciprocal translocation between chromosomes 8 and 10 , and an inversion of chromosome 3 . | NA | {
"id": "C0008626",
"name": "chromosomopathies",
"pos": [
13,
30
]
} | {
"id": "C0021943",
"name": "inversion",
"pos": [
168,
177
]
} |
the investigation has been performed on 87 corpses of persons of both sex , that died after 60 years of age from the pathology not connected with any diseases in the neck organs . | NA | {
"id": "C0006629",
"name": "corpses",
"pos": [
43,
50
]
} | {
"id": "C0011065",
"name": "died",
"pos": [
81,
85
]
} |
in a patient presenting with hematuria and proteinuria ( albuminuria ) , bladder biopsy demonstrated schistosoma hematobium infection and renal biopsy showed a minimal change glomerulonephritis . | NA | {
"id": "C0033687",
"name": "proteinuria",
"pos": [
43,
54
]
} | {
"id": "C0001925",
"name": "albuminuria",
"pos": [
57,
68
]
} |
if the ph in the immobilized enzyme layer is thus controlled , the resulting ph-static enzyme sensor has an output that is independent of the sample ph and buffer capacity and has an expanded linear range . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
17,
35
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
87,
93
]
} |
in maturing sperm of the winter flounder , histones are not replaced by protamines but instead joined by a group of high molecular weight basic nuclear proteins . | NA | {
"id": "C0019652",
"name": "histones",
"pos": [
43,
51
]
} | {
"id": "C0028589",
"name": "nuclear",
"pos": [
144,
151
]
} |
in maturing sperm of the winter flounder , histones are not replaced by protamines but instead joined by a group of high molecular weight basic nuclear proteins . | NA | {
"id": "C0033603",
"name": "protamines",
"pos": [
72,
82
]
} | {
"id": "C0028589",
"name": "nuclear",
"pos": [
144,
151
]
} |
the dodecapeptide and heptapeptide sequences form at least 35 and 11 % , respectively , of the high molecular weight basic nuclear proteins and are , therefore , repeated many times over in these proteins . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
123,
139
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
196,
204
]
} |
rather , these results indicate that some african hiv infected patients fail to make detectable antibodies to hiv or the antibodies were bound in immune complexes not detectable by current techniques . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
96,
106
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
146,
162
]
} |
these data suggest that heterosexual transmission of hiv can occur during routine vaginal intercourse but that it usually does not occur until the hemophiliac has severe immune deficiency late in the course of hiv infection . | NA | {
"id": "C0021051",
"name": "immune deficiency",
"pos": [
170,
187
]
} | {
"id": "C0019693",
"name": "hiv",
"pos": [
210,
213
]
} |
the present data are consistent with similar observations in male homosexuals with aids-related complex and confirm that the hiv infection induces a broad spectrum of immunological abnormalities leading to a progressive derangement of the immunocompetence . | NA | {
"id": "C0001857",
"name": "aids-related complex",
"pos": [
83,
103
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
125,
138
]
} |
the inhibitor is a protein which does not bind to dna or inhibit dnase i , so that it has also been useful in assays for dna binding proteins in crude , dnase-contaminated fractions . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
19,
26
]
} | {
"id": "C0012940",
"name": "dna binding proteins",
"pos": [
121,
141
]
} |
a comparative study of substrate specificity of cathepsin d and high molecular weight aspartic peptidase with the use of fluorescent substrate with inner fluorescence quenching , abz-ala-ala-phe-phe-pna , revealed that both peptidases hydrolyzed the single bond between two phenylalanine residues , resulting in the incr... | NA | {
"id": "C0007428",
"name": "cathepsin",
"pos": [
48,
57
]
} | {
"id": "C0030940",
"name": "peptidases",
"pos": [
224,
234
]
} |
a comparative study of substrate specificity of cathepsin d and high molecular weight aspartic peptidase with the use of fluorescent substrate with inner fluorescence quenching , abz-ala-ala-phe-phe-pna , revealed that both peptidases hydrolyzed the single bond between two phenylalanine residues , resulting in the incr... | NA | {
"id": "C2717969",
"name": "aspartic peptidase",
"pos": [
86,
104
]
} | {
"id": "C0030940",
"name": "peptidases",
"pos": [
224,
234
]
} |
two transfer rna sequences abut the large ribosomal rna gene in tetrahymena mitochondrial dna : trna ( leu ) ( anticodon uaa ) and trna ( met ) ( anticodon cau ) . | NA | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
4,
16
]
} | {
"id": "C0003284",
"name": "anticodon",
"pos": [
146,
155
]
} |
messenger rna levels were measured by dna/rna filter-hybridisation with pulse labelled rnas during 6-azauridine ( 6-aur ) inhibited growth in wild type and 6-aur sensitive strains . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
0,
13
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
87,
90
]
} |
antigen t ( thomsen-friedenreich ) , a precursor of blood group mn antigens , with the determinant of a carbohydrate ( gal-galnac ) , antigen lewisx ( lex ) , a trisaccharide found on type 2 blood group oligosaccharide chains , sialo-lex , the derivatives : of lex and lewisy ( ley ) , a difucosylated tetrasaccharide ha... | NA | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
161,
174
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
203,
218
]
} |
the results showed that in plc patients , plasma total amino acid ( taa ) , branched chain amino acid ( bcaa ) , glycogenic amino acid , glutamine , histidine and arginine were lowered , while plasma aromatic amino acid ( aaa ) and methionine did not decrease significantly resulting in the bcaa/aaa ratio decline . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
55,
65
]
} | {
"id": "C0002521",
"name": "bcaa",
"pos": [
291,
295
]
} |
comparing 8/22 subclinical and 14/22 clinical liver cancers with healthy controls respectively , it was found that there was a decrease of plasma taa , glutamine , arginine , histidine , bcaa and bcaa/aaa ratio , and an increase of tyrosine , in subclinical stage of plc . | NA | {
"id": "C0002520",
"name": "taa",
"pos": [
146,
149
]
} | {
"id": "C0002521",
"name": "bcaa",
"pos": [
196,
200
]
} |
comparing 8/22 subclinical and 14/22 clinical liver cancers with healthy controls respectively , it was found that there was a decrease of plasma taa , glutamine , arginine , histidine , bcaa and bcaa/aaa ratio , and an increase of tyrosine , in subclinical stage of plc . | NA | {
"id": "C0301713",
"name": "aaa",
"pos": [
201,
204
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
232,
240
]
} |
virgin female rats of sd strain were given ad libitum a nutritionally adequate semipurified diet containing 0.026 ppm molybdenum and deionized water ( groups 1-3 ) or the same diet with 150 ppm tungsten and the drinking water ( group 4 ) . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
143,
148
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
211,
225
]
} |
they were 15 ( 17 foci ) adenoid cystic carcinomas , 3 carcinoids , 2 mucoepidermoid carcinomas , 1 well-differentiated adenocarcinoma , leiomyosarcoma and extramedullary plasmocytoma each . | NA | {
"id": "C0010606",
"name": "adenoid cystic carcinomas",
"pos": [
25,
50
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
120,
134
]
} |
they were 15 ( 17 foci ) adenoid cystic carcinomas , 3 carcinoids , 2 mucoepidermoid carcinomas , 1 well-differentiated adenocarcinoma , leiomyosarcoma and extramedullary plasmocytoma each . | NA | {
"id": "C0007095",
"name": "carcinoids",
"pos": [
55,
65
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
120,
134
]
} |
they were 15 ( 17 foci ) adenoid cystic carcinomas , 3 carcinoids , 2 mucoepidermoid carcinomas , 1 well-differentiated adenocarcinoma , leiomyosarcoma and extramedullary plasmocytoma each . | NA | {
"id": "C0206694",
"name": "mucoepidermoid carcinomas",
"pos": [
70,
95
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
120,
134
]
} |
the authors ' data suggest that the differences in the behaviour of dactimicin , gentamicin and amikacin against the aminoglycoside-resistant strains tested were mainly due to the production of aminoglycoside-modifying enzymes . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
81,
91
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
194,
208
]
} |
in this study the cellular toxicity of two aminoglycosides ( gentamicin and dactimicin ) have been evaluated using rabbit kidney cell cultures . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
43,
58
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
61,
71
]
} |
dc exhibits a greater antibacterial activity than other aminoglycosides against the clinical isolates of serratia marcescens and is active against many gentamicin- and amikacin-resistant bacteria . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
56,
71
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
152,
162
]
} |
the present study compares the renal effects of dc versus gentamicin ( gt ) and amikacin ( ak ) , respectively the most and the least nephrotoxic pseudotrisaccharide aminoglycosides in present use ( 2 ) , evaluating the urinary nag excretion and the histological changes induced in the kidney . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
58,
68
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
166,
181
]
} |
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