text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
neuropeptide y ( npy ) and calcitonin gene-related peptide ( cgrp ) are both intrapancreatic neuropeptides that are known to inhibit stimulated insulin secretion . | NA | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
0,
14
]
} | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
93,
106
]
} |
neuropeptide y ( npy ) and calcitonin gene-related peptide ( cgrp ) are both intrapancreatic neuropeptides that are known to inhibit stimulated insulin secretion . | NA | {
"id": "C0006669",
"name": "calcitonin gene-related peptide",
"pos": [
27,
58
]
} | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
93,
106
]
} |
the effect of the hypoglycaemic biguanide , metformin , on insulin binding and insulin action was investigated in rat hepatocyte monolayers . | NA | {
"id": "C0005382",
"name": "biguanide",
"pos": [
32,
41
]
} | {
"id": "C0025598",
"name": "metformin",
"pos": [
44,
53
]
} |
the postprandial blood glucose and serum insulin responses to liquid test meals containing 40 g carbohydrate from milk , lactose , glucose or fructose and equal amounts of energy were compared in 10 non-insulin-dependent ( type 2 ) diabetic patients . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
17,
30
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
131,
138
]
} |
the intravenous administration of the long-acting met-enkephalin analogue damme ( 0.25 mg ) blunted the hormonal responses to the subsequent beta-endorphin infusion in diabetic patients , although the inhibition was short-lived ( 30-40 min ) . | NA | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
50,
64
]
} | {
"id": "C0949300",
"name": "damme",
"pos": [
74,
79
]
} |
severe atrophic gastritis was less frequently infected with clo ( 55.5 % ) as compared with superficial , interstitial or preatrophic gastritis ( 84.4 % ) . | NA | {
"id": "C0017154",
"name": "atrophic gastritis",
"pos": [
7,
25
]
} | {
"id": "C0017152",
"name": "gastritis",
"pos": [
134,
143
]
} |
comparison of the distribution of cells expressing cytokeratins and/or desmin with that of reticulum cells showing strong alkaline phosphatase activity ( as a marker for the so-called `` '' fiber-associated ( fibroblastic ) reticulum cells '' '' ) suggests that the former represent a subset of the latter . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
34,
39
]
} | {
"id": "C0016030",
"name": "( fibroblasti",
"pos": [
207,
220
]
} |
the effects of nifedipine and nicardipine , 2 dihydropyridines ( dhp ) used in the treatment of cardiovascular disorders , were compared in frog atrial fibers . | NA | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
15,
25
]
} | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
46,
62
]
} |
the effects of nifedipine and nicardipine , 2 dihydropyridines ( dhp ) used in the treatment of cardiovascular disorders , were compared in frog atrial fibers . | NA | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
30,
41
]
} | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
46,
62
]
} |
the concentration of 17-oh-progesterone was determined in second trimester amniotic fluid collected from 58 pregnancies at risk for fetal 21-hydroxylase deficiency . | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
58,
74
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
108,
119
]
} |
the culture of bovine monocyte-depleted peripheral blood mononuclear cells ( pbm ) ( responder ) with irradiated autologous undepleted pbm ( stimulator ) resulted in a strong proliferative response , which was called the bovine autologous mixed leukocyte reaction ( mlr ) . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C1321301",
"name": "pbm",
"pos": [
135,
138
]
} |
the cellular interactions between t cells and allogeneic cells which are involved in the triggering of lymphokine release from t cells are still poorly understood . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
4,
12
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
46,
62
]
} |
two related folate antagonists aminopterin ( amn ) and methotrexate ( mtx ) were used to produce drug-antibody conjugates and their tumouricidal effects compared in vitro and in vivo . | NA | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
31,
42
]
} | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
55,
67
]
} |
approximately 11 molecules of amn or 13 molecules of mtx were specifically bound per molecule of anti-ly-2.1 , with good retention of antibody activity and protein recovery . | NA | {
"id": "C0002583",
"name": "amn",
"pos": [
30,
33
]
} | {
"id": "C0025677",
"name": "mtx",
"pos": [
53,
56
]
} |
amn was a more effective inhibitor of tumour cell growth in vitro than mtx , and amn-anti-ly-2.1 conjugates were also more potent in vitro than mtx-anti-ly-2.1 conjugates . | NA | {
"id": "C0002583",
"name": "amn",
"pos": [
0,
3
]
} | {
"id": "C0025677",
"name": "mtx",
"pos": [
144,
147
]
} |
although there was some loss of drug activity on binding to antibody , amn-moab conjugates were as toxic as free mtx . | NA | {
"id": "C0002583",
"name": "amn",
"pos": [
71,
74
]
} | {
"id": "C0025677",
"name": "mtx",
"pos": [
113,
116
]
} |
in addition , amn-moab conjugates were effective anti-tumour agents in vivo , and in mice bearing established thymoma grafts amn-moab conjugates inhibited tumour proliferation better than mtx-moab , free amn or mtx or antibody alone . | NA | {
"id": "C0003250",
"name": "moab",
"pos": [
18,
22
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
218,
226
]
} |
in addition , amn-moab conjugates were effective anti-tumour agents in vivo , and in mice bearing established thymoma grafts amn-moab conjugates inhibited tumour proliferation better than mtx-moab , free amn or mtx or antibody alone . | NA | {
"id": "C0002583",
"name": "amn",
"pos": [
14,
17
]
} | {
"id": "C0025677",
"name": "mtx",
"pos": [
211,
214
]
} |
further studies on the heterogeneity of antigens recognised by cd-1 monoclonal antibodies : distribution of epitopes and analysis of serological binding patterns . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
40,
48
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
108,
116
]
} |
from the homogenate of rat submaxillary gland , two kinds of serine proteinases , named tentatively proteinases a and b , were isolated and their chemical properties and activities toward rat kininogens were examined , in comparison with those of submaxillary kallikrein . | NA | {
"id": "C2717971",
"name": "serine proteinases",
"pos": [
61,
79
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
100,
111
]
} |
the nh2-terminal amino acid sequences of proteinases a and b were different from each other , and distinguishable with those of serine proteinases in rat submaxillary gland so far reported . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
41,
52
]
} | {
"id": "C2717971",
"name": "serine proteinases",
"pos": [
128,
146
]
} |
one of the microtubule associated proteins , tau factor , that appears associated to the paired helical filaments of alzheimer 's disease presents , by itself , after urea treatment , the ability of polymerizing in vitro as tested by immunoelectronmicroscopy . | NA | {
"id": "C0026045",
"name": "microtubule associated proteins",
"pos": [
11,
42
]
} | {
"id": "C0085401",
"name": "tau factor",
"pos": [
45,
55
]
} |
incubation of human promyelocytic leukemia ( hl-60 ) cells with 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) , a protein kinase c-activating phorbol ester , caused a marked increase in c-fos mrna in a dose-dependent manner . | NA | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol-13-acetate",
"pos": [
64,
101
]
} | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
142,
155
]
} |
the kinetic mechanism of two major monomeric 17 beta-hydroxysteroid dehydrogenases from mouse liver cytosol was studied at ph 7 in both directions with nadp ( h ) and three steroid substrates : testosterone , 5 beta-androstane-3 alpha , 17 17 beta-diol , and estradiol-17 beta . | NA | {
"id": "C0038317",
"name": "steroid",
"pos": [
60,
67
]
} | {
"id": "C0002854",
"name": "androstane",
"pos": [
216,
226
]
} |
[ preliminary results of a randomized trial comparing the efficacy of standard heparin with that of fragmine , a low molecular weight heparin , in the prevention of postoperative thrombosis in cancer surgery ] . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
79,
86
]
} | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
113,
141
]
} |
a randomized study in 50 patients compared efficacy of low doses of a standard heparin , calciparin ( 5,000 iu/8 h ) with that of a low molecular weight heparin , fragmine ( kabi 2165 ) ( 5,000 anti-xa u/24 h ) , in the prophylaxis of postoperative thrombosis after oncologic surgery . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
79,
86
]
} | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
194,
201
]
} |
the origin , dose and mode of administration of the heparin did not appear determinant in the production of the thrombocytopenia : 16 of the patients were later treated with a low molecular weight heparin ( lmwh ) . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
52,
59
]
} | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
176,
204
]
} |
concordance exists therefore between negativity of the test practiced with lmwh and the increase in count when this heparin is administered ; | NA | {
"id": "C0019139",
"name": "lmwh",
"pos": [
75,
79
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
116,
123
]
} |
[ efficacy of a very low molecular weight heparin fragment ( cy 222 ) compared to standard heparin in patients with deep venous thrombosis . a randomized study ] . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
21,
49
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
91,
98
]
} |
low molecular weight heparin fractions have been demonstrated as efficient as low doses of standard heparin in preventing post-operative deep-vein thrombosis . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
0,
28
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
100,
107
]
} |
several clinical studies are , now , carrying out in patients with acute deep-vein thrombosis in order to assess efficacy and safety of low molecular weight heparin fractions as compared to standard heparin . | NA | {
"id": "C0019139",
"name": "low molecular weight",
"pos": [
136,
156
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
199,
206
]
} |
in a randomised study including patients with deep-vein thrombosis treated either with low molecular weight heparin or with subcutaneously standard heparin , we demonstrated an effectiveness , in terms of thrombus reduction , of low molecular weight heparin as well as standard heparin . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
87,
115
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
278,
285
]
} |
preliminary results of the use of heparin fractions of low molecular weight showed improved bioavailability , sustained pharmacological actions and less bleeding than with non-fractionated heparin . | NA | {
"id": "C0019139",
"name": "heparin",
"pos": [
34,
41
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
189,
196
]
} |
clinical evaluation of a new one-stage clotting assay for heparin and low molecular weight heparins . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
58,
65
]
} | {
"id": "C0019139",
"name": "low",
"pos": [
70,
73
]
} |
heptest , a new one-stage clotting assay was compared with the anti-factor xa chromogenic substrate s 2222 method , the thrombin clotting time ( tct ) , and the activated partial thromboplastin time ( aptt ) tests in 100 patients receiving unfractionated mucosal heparin , and 100 patients treated with kabi 2165 low mol... | NA | {
"id": "C0019134",
"name": "unfractionated",
"pos": [
240,
254
]
} | {
"id": "C0019139",
"name": "low",
"pos": [
313,
316
]
} |
the results indicate a high correlation between the heptest and the anti-xa chromogenic substrate method ( r = 0.91 for unfractionated heparin , and 0.90 for kabi 2165 low molecular weight heparin ) . | NA | {
"id": "C0019134",
"name": "unfractionated heparin",
"pos": [
120,
142
]
} | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
168,
196
]
} |
the correlations between the heptest and the aptt were 0.36 for unfractionated heparin , and 0.14 for low molecular weight heparin , while those of the tct were 0.36 and 0.27 , respectively . | NA | {
"id": "C0019134",
"name": "unfractionated",
"pos": [
64,
78
]
} | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
102,
130
]
} |
[ biological modifications induced by 3 low molecular weight heparins , pk 10169 , kabi 2165 and cy 216 , compared to unfractionated heparin injected subcutaneously in healthy subjects in general surgery and in aged subjects in internal medicine ] . | NA | {
"id": "C0019139",
"name": "low molecular weight heparins",
"pos": [
40,
69
]
} | {
"id": "C0019134",
"name": "unfractionated heparin",
"pos": [
118,
140
]
} |
after heparin injection , the anti-xa/anti-iia ratio was 1 but activities were weak ( 5,000 iu x 2 = 0.02 +/- 0.02 ) , a little higher with 5,000 iu x 3 ( 0.05 +/- 0.04 ) . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
6,
13
]
} | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
30,
37
]
} |
a series of 80 patients operated for total hip prosthesis under epidural anesthesia was randomly allocated to treatment with kabi 2165 ( n = 40 ) : 2,500 u anti-xa preoperatively and evening of operation and 2,500 u anti-xa morning and evening daily up to the 9th or 10th day postoperatively , or standard heparin ( n = ... | NA | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
156,
163
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
306,
313
]
} |
efficacy of a low molecular weight heparin ( kabi 2165 ) was compared with that of non-fractionated heparin in the prevention of abdominal surgery postoperative venous thrombosis by means of a double-blind randomized trial in 79 patients . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
14,
42
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
100,
107
]
} |
the predicted polypeptide products of two genes , spoiid and gere , which appear to be concerned in the regulation of spore formation in bacillus subtilis have been compared by modelling methods with known dna-binding proteins . | NA | {
"id": "C0033684",
"name": "products",
"pos": [
26,
34
]
} | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
206,
226
]
} |
however , the mutant protein retained sufficient residual activity to cause partial , mg2+-suppressible lysis and could activate envelope phospholipase a1-a2 and promote colicin release , albeit with reduced efficiency compared to the wild-type protein . | NA | {
"id": "C1564139",
"name": "mutant protein",
"pos": [
14,
28
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
245,
252
]
} |
we propose that the uncleaved signal peptide of the mutant protein acts as the functional equivalent of the fatty acyl groups normally linked to the n-terminal cysteine residue of the wild-type protein , thereby anchoring the protein in the cell envelope where it exerts its various effects . | NA | {
"id": "C1564139",
"name": "mutant protein",
"pos": [
52,
66
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
226,
233
]
} |
circulating antigens and antibodies in human and mouse dermatophytosis : use of monoclonal antibody reactive to phosphorylcholine-like epitopes . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
12,
20
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
135,
143
]
} |
cefotiam ( ctm ) , cefotaxime ( ctx ) , ceftizoxime ( czx ) , cefmenoxime ( cmx ) and latamoxef ( lmox ) had mic90 below 0.39 micrograms/ml . | NA | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
0,
8
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
19,
29
]
} |
cefotiam ( ctm ) , cefotaxime ( ctx ) , ceftizoxime ( czx ) , cefmenoxime ( cmx ) and latamoxef ( lmox ) had mic90 below 0.39 micrograms/ml . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
19,
29
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
40,
51
]
} |
cefotiam ( ctm ) , cefotaxime ( ctx ) , ceftizoxime ( czx ) , cefmenoxime ( cmx ) and latamoxef ( lmox ) had mic90 below 0.39 micrograms/ml . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
19,
29
]
} | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
62,
73
]
} |
among injectable antibiotics , third generation cephems showed the strongest activity to this species with mic90 of czx below 0.10 micrograms/ml , of ctx and cmx 0.20 micrograms/ml , and of lmox 0.78 micrograms/ml . | NA | {
"id": "C0007560",
"name": "czx",
"pos": [
116,
119
]
} | {
"id": "C0007554",
"name": "ctx",
"pos": [
150,
153
]
} |
among injectable antibiotics , third generation cephems showed the strongest activity to this species with mic90 of czx below 0.10 micrograms/ml , of ctx and cmx 0.20 micrograms/ml , and of lmox 0.78 micrograms/ml . | NA | {
"id": "C0007554",
"name": "ctx",
"pos": [
150,
153
]
} | {
"id": "C0007549",
"name": "cmx",
"pos": [
158,
161
]
} |
among third generation cephems , including cefmenoxime ( cmx ) , latamoxef ( lmox ) , ceftizoxime ( czx ) , cefotaxime ( ctx ) and cefoperazone ( cpz ) , the strongest activity was observed with czx , and the agent having the next strongest activity was cmx . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
108,
118
]
} | {
"id": "C0007560",
"name": "czx",
"pos": [
195,
198
]
} |
among third generation cephems , including cefmenoxime ( cmx ) , latamoxef ( lmox ) , ceftizoxime ( czx ) , cefotaxime ( ctx ) and cefoperazone ( cpz ) , the strongest activity was observed with czx , and the agent having the next strongest activity was cmx . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
108,
118
]
} | {
"id": "C0007549",
"name": "cmx",
"pos": [
254,
257
]
} |
when activities of oral cephems ( cephalexin ( cex ) and ccl ) and of a quinoline derivative oflx against these strains were determined , oflx showed strong activity ; | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
34,
44
]
} | {
"id": "C0007537",
"name": "ccl",
"pos": [
57,
60
]
} |
[ infection defense antigens against pathogenic viruses to human . molecular conformation of infection defense antigenic determinants and immunogenecity ] . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
20,
28
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
111,
133
]
} |
species differences in the pattern of linker histones were detected when the nuclear proteins of human and mouse retinas were compared . | NA | {
"id": "C0019652",
"name": "histones",
"pos": [
45,
53
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
77,
93
]
} |
non-histone nuclear proteins are more abundant in the adult human retina than in the mouse retina or the fetal human retina . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
4,
11
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
12,
28
]
} |
drugs used were 5-hydroxytryptamine ( 5-ht ) , epinephrine ( epi ) , norepinephrine ( ne ) , phenylephrine ( phe ) , prostaglandin f2 alpha ( pgf2 alpha ) , atp , dopamine ( da ) , tyramine ( tyr ) , kcl , xylazine ( xyl ) and clonidine ( clo ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
47,
58
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
69,
83
]
} |
results were as follows : 1 ) the rank order of potency for inducing a vasoconstriction in external ophthalmic arteries ( eoa ) was 5-ht greater than or equal to epi greater than ne greater than phe much greater than atp greater than or equal to da greater than kcl much much greater than tyr , xyl , clo . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
162,
165
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
179,
181
]
} |
2 ) in internal ophthalmic arteries ( ioa ) , the responses were similar to those in eoa , although epi , ne and phe induced a relatively smaller response . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
100,
103
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
106,
108
]
} |
the order was 5-ht greater than epi = ne greater than phe much greater than da = atp greater than kcl much much greater than tyr , xyl , clo . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
32,
35
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
38,
40
]
} |
3 ) in ciliary arteries , the order was epi greater than ne greater than phe greater than pgf2 alpha greater than da greater than atp greater than kcl much much greater than tyr , xyl , clo . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
40,
43
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
57,
59
]
} |
the types of epilepsy in 224 patients with intractable epilepsy whose seizures were not adequately controlled and recurred on a monthly basis in spite of hospitalization were classified as follows : 101 patients with localization-related epilepsies or syndromes , 106 with generalized epilepsies or syndromes , 16 with u... | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
70,
78
]
} | {
"id": "C0014544",
"name": "epilepsies",
"pos": [
332,
342
]
} |
in regard to partial epilepsies , frontal lobe epilepsy and partial epilepsy with multiple foci were at least partially intractable as temporal lobe epilepsy . | NA | {
"id": "C0085541",
"name": "frontal lobe epilepsy",
"pos": [
34,
55
]
} | {
"id": "C0014547",
"name": "partial",
"pos": [
110,
117
]
} |
in regard to partial epilepsies , frontal lobe epilepsy and partial epilepsy with multiple foci were at least partially intractable as temporal lobe epilepsy . | NA | {
"id": "C0014547",
"name": "partial",
"pos": [
13,
20
]
} | {
"id": "C0014556",
"name": "temporal lobe",
"pos": [
135,
148
]
} |
the clinical features of the refractory group were the onset of epilepsy during the first year of life , absence of family history , retarded development before the onset , phakomatoses , daily or weekly seizures , secondarily generalized epilepsy , and marked eeg abnormalities at the initial visit , a change of types ... | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
204,
212
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
323,
331
]
} |
since both the el mouse and kindling preparations have been regarded as complex partial seizure with secondary generalization , endogenous brain trh , as well as exogenous trh , may act as an anticonvulsant substance to such a seizure type of epilepsy . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
88,
95
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
243,
251
]
} |
the effects of neuropeptides : substance p , somatostatin , neurotensin and enkephalins on the myoelectric activity of the small intestine . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
15,
28
]
} | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
60,
71
]
} |
although no significant amino acid sequence homology was found with other transport proteins , such as the arabinose , citrate , glucose , melibiose , lactose or xylose transporters , all of these proteins share a common secondary structure arrangement with the glp t protein as they apparently contain twelve membrane-s... | NA | {
"id": "C0007292",
"name": "transport proteins",
"pos": [
74,
92
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
197,
205
]
} |
according to their activity profiles tick pheromones can be characterized as assembly pheromones , aggregation/attachment pheromones , pre-attachment or pre-feeding pheromones , attractant sex pheromones , contact sex pheromones , fecundity-reducing pheromone and various ungrouped pheromones . | NA | {
"id": "C0036863",
"name": "sex pheromones",
"pos": [
189,
203
]
} | {
"id": "C0031516",
"name": "pheromones",
"pos": [
282,
292
]
} |
reference is made to the possibilities of genetic manipulation , problems accompanying the implementation of sterile male techniques , and hybrid sterility . | NA | {
"id": "C0021364",
"name": "sterile male",
"pos": [
109,
121
]
} | {
"id": "C0021359",
"name": "sterility",
"pos": [
146,
155
]
} |
in prepubertal ( 28 days of age ) and pubertal ( 45 days of age ) rats , mitotic indices were 2 and 0.2 % , respectively , in the leydig cells and 0.4 and 0.1 % in fibroblast-like and myoid cells , respectively . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
164,
174
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
190,
195
]
} |
reactivity of the antigen with monoclonal and polyclonal anti-cea antibodies recognising different epitopes was analysed by western blotting . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
18,
25
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
99,
107
]
} |
therefore , both of the antibody preparations , anti-tf2 and anti-tf3 , could be inhibited by gal-beta- ( 1-3 ) galnac , but showed preference to one or the other sugar component of the disaccharide resulting in a differential recognition of glycoconjugate inhibitors . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
163,
168
]
} | {
"id": "C0017906",
"name": "glycoconjugate",
"pos": [
242,
256
]
} |
comparisons were made of the in vitro activity of rifampicin , and the rifamycin derivatives , rifapentine , rifabutin , cgp 29861 , cgp 7040 and cgp 27557 , against rifampicin-sensitive and rifampicin-resistant strains of mycobacterium tuberculosis and against the mycobacterium avium/intracellulare/scrofulaceum ( mais... | NA | {
"id": "C0035609",
"name": "rifamycin",
"pos": [
71,
80
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
191,
201
]
} |
the new rifamycins had mics four to eight times lower than those of rifampicin against sensitive m. tuberculosis strains . | NA | {
"id": "C0035609",
"name": "rifamycins",
"pos": [
8,
18
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
68,
78
]
} |
of the 35 rifampicin-resistant strains of m. tuberculosis , 31 % were sensitive to rifabutin but only 3-11 % to the other rifamycins . | NA | {
"id": "C0140575",
"name": "rifabutin",
"pos": [
83,
92
]
} | {
"id": "C0035609",
"name": "rifamycins",
"pos": [
122,
132
]
} |
the bactericidal activity of six new rifamycin derivatives -- rifabutin ( rbu ) , fce 22250 ( f22 ) , rifapentine ( rpe ) , cgp 29861 ( c29 ) , cgp 7040 ( c70 ) and cgp 27557 ( c27 ) and rifampicin ( rmp ) -- have been measured against log phase and , as a better test of sterilising activity , against stationary phase ... | NA | {
"id": "C0035609",
"name": "rifamycin",
"pos": [
37,
46
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
187,
197
]
} |
the order of activity of 1.0 and 0.2 mg/l rifamycin against log phase cultures was rmp greater than rpe & c27 greater than rbu & c29 greater than c70 . | NA | {
"id": "C0035608",
"name": "rmp",
"pos": [
83,
86
]
} | {
"id": "C0073372",
"name": "c27",
"pos": [
106,
109
]
} |
the order of activity of 1.0 and 0.4 mg/l , adjusted for stability of the rifamycin , against stationary phase cultures was f22 & rmp greater than rbu greater than rpe greater than c27 & c29 greater than c70 . | NA | {
"id": "C0035609",
"name": "rifamycin",
"pos": [
74,
83
]
} | {
"id": "C0035608",
"name": "rmp",
"pos": [
130,
133
]
} |
in previous publications from this laboratory we suggested the use of radioprotective drugs in a sustained-release form as a practical way to cope with their high toxicity and quick metabolism and excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
182,
192
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
197,
206
]
} |
infrared spectra of hemoglobin ( met-hemoglobin ) and myoglobin were recorded in the temperature range -110 degrees c to 30 degrees c . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
20,
30
]
} | {
"id": "C0025635",
"name": "met-hemoglobin",
"pos": [
33,
47
]
} |
toxic endotoxin ( lps ) and its irradiated detoxified form ( rd-lps ) induced only small changes in the dna level in the sera of 4 , 12 and 18 months old rats . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
6,
15
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
64,
67
]
} |
apgar scores at 1 and 5 minutes were recorded and plasma adrenalin , noradrenalin were measured in umbilical arterial blood at birth , together with ph , pco2 and base excess and beta-endorphin-like immunoreactivity in umbilical venous blood . | NA | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
57,
66
]
} | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
69,
81
]
} |
over the past five years , the proportion of aids cases among gay and bisexual men in new york city has fallen as the proportion of aids cases has risen among iv drug abusers , the major channel of hiv infection to children and heterosexuals in new york city . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
45,
49
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
198,
211
]
} |
human immunodeficiency virus ( hiv ) infection produces a spectrum of clinical syndromes , progressing in severity from asymptomatic infection through the life-threatening diseases of the acquired immunodeficiency syndrome ( aids ) . | NA | {
"id": "C0019693",
"name": "human immunodeficiency virus",
"pos": [
0,
28
]
} | {
"id": "C0001175",
"name": "diseases",
"pos": [
172,
180
]
} |
current knowledge about the epidemiology , virology , and clinical manifestations of hiv infection and aids are reviewed . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
85,
98
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
103,
107
]
} |
the ultrastructure of epiphyseal chondrocytes was studied following quick-freezing and freeze-substitution , and was compared to that of cells fixed with aqueous aldehydes . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
33,
45
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
137,
142
]
} |
the former approach provided an improved ultrastructural preservation whereby every type of chondrocyte exhibited a smoother cell contour . | NA | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
92,
103
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
125,
129
]
} |
using immunocytochemistry we have shown that the goldfish tn contains neuropeptides related to the molluscan cardioexcitatory peptide ( fmrfamide ) as well as luteinizing hormone-releasing hormone ( lhrh ) . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
70,
83
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
136,
145
]
} |
although 9 patients died it was not possible to determine prognostic value of pleds specifically for each pathological condition . | NA | {
"id": "C0011065",
"name": "died",
"pos": [
20,
24
]
} | {
"id": "C0030660",
"name": "pathological condition",
"pos": [
106,
128
]
} |
selection factors for family therapy in the treatment of anorexia nervosa are illustrated by a report on 23 consecutive referrals to an eating disorder clinic . | NA | {
"id": "C0003125",
"name": "anorexia nervosa",
"pos": [
57,
73
]
} | {
"id": "C0013473",
"name": "eating disorder",
"pos": [
136,
151
]
} |
a case is presented of psoriasis occurring de novo during lithium therapy and progressing to psoriatic arthritis . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
23,
32
]
} | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
93,
112
]
} |
to characterize the effects of a new calcium antagonist of the dihydropyridine type , 1,4-dihydro-2,6-dimethyl-4- ( 3-nitrophenyl ) -3,5-pyridinedicarboxylic++ + acid methyl 6- ( 5-phenyl-3-pyrazolyloxy ) hexyl ester ( cv-159 ) on the cardiovascular system , experiments were performed in the anesthetized open-chest dog... | NA | {
"id": "C2945601",
"name": "calcium antagonist",
"pos": [
37,
55
]
} | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
403,
414
]
} |
the metabolites of 1-tert.-butylamino-3- ( 2-cyclopentylphenoxy ) propan-2-ol ( penbutolol , betapressin ) , penbutolol 2-glucuronide , 4'-oh-penbutolol 2-glucuronide , 4'-oh-penbutolol 4-sulfate and 1 '' '' -dehydropenbutolol 2-glucuronide were determined in urine by high-performance liquid chromatography ( hplc ) . | NA | {
"id": "C0030812",
"name": "penbutolol",
"pos": [
80,
90
]
} | {
"id": "C0282292",
"name": "penbutolol",
"pos": [
216,
226
]
} |
a fused silica , bonded phase capillary column , combined with negative ion chemical ionization ( nici ) , ammonia as a selective reagent gas and the monitoring of preselected characteristic ions ( sim ) , provide the combined sensitivity and selectivity necessary for reliable measurements in the low ng/ml range . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
107,
114
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
138,
141
]
} |
we have synthesized acetal and ketal derivatives of 4'-demethylepipodophyllotoxin-beta-d-glucoside ( dmepg ) and epipodophyllotoxin-beta-d-glucoside ( epg ) with a number of different aldehydes ( viz . acetaldehyde , propionaldehyde , 2-thiophenecarboxaldehyde , 3-thiophenecarboxaldehyde , 2-furancarboxaldehyde , benza... | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
184,
193
]
} | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
336,
348
]
} |
we have synthesized acetal and ketal derivatives of 4'-demethylepipodophyllotoxin-beta-d-glucoside ( dmepg ) and epipodophyllotoxin-beta-d-glucoside ( epg ) with a number of different aldehydes ( viz . acetaldehyde , propionaldehyde , 2-thiophenecarboxaldehyde , 3-thiophenecarboxaldehyde , 2-furancarboxaldehyde , benza... | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
184,
193
]
} | {
"id": "C0016849",
"name": "2-furancarboxaldehyde",
"pos": [
291,
312
]
} |
viscometric measurements using covalently closed-circular dna and sonicated rod-like fragments of calf thymus dna show that the dna-binding anti-cancer drug bisantrene intercalates with a helix unwinding angle of 14 degrees , and causes an increase in dna contour length of 2.8a per bound drug molecule . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
49,
61
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
252,
255
]
} |
the present data document the long-term effects of hiv infection in a seropositive cohort and suggest the possibility of a subgroup particularly susceptible to the progressive effects of hiv that precede the development of the acquired immunodeficiency syndrome ( aids ) . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
51,
64
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
264,
268
]
} |
decreased expression of the c3b/c4b complement receptor ( cr1 ) in aids and aids-related syndromes correlates with clinical subpopulations of patients with hiv infection . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
67,
71
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
156,
169
]
} |
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