text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these 4 m guanidinium chloride soluble , cold water soluble protein fractions initiate a dose-dependent increase in the amount of cartilage formed following an 8-10 day continuous exposure as evidenced by the presence of greater numbers of chondrocytes when viewed with phase optics , more intense toluidine blue metachr... | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
240,
252
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
400,
404
]
} |
the five-point dyspnoea scale predicts similar levels of performance in the 12-minute walking test whether the dyspnoea is a result of cardiac or respiratory disease . | NA | {
"id": "C0013404",
"name": "dyspnoea",
"pos": [
15,
23
]
} | {
"id": "C0035204",
"name": "respiratory disease",
"pos": [
146,
165
]
} |
lateral diffusion of membrane proteins is slower than expected by theory , due to both the effect of protein crowding in the membrane and to constraints from the aqueous matrix . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
21,
38
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
101,
108
]
} |
diffusion of elements was reduced to a minimum by rapidly freezing the tissue samples between nitrogen-cooled polished copper surfaces and avoiding the use of chemical fixatives and stains . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
13,
21
]
} | {
"id": "C0028158",
"name": "nitrogen",
"pos": [
94,
102
]
} |
the direct effect is expressed in the improved microcirculation , disappearance of the sludge-syndrome and the reduction of ischemic disorders . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
94,
102
]
} | {
"id": "C0012634",
"name": "disorders",
"pos": [
133,
142
]
} |
new vlmw heparins are described which are pure , monodisperse , structurally defined drugs and show improved pharmacokinetics and greater specificity than heparin . | NA | {
"id": "C0019139",
"name": "vlmw heparins",
"pos": [
4,
17
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
155,
162
]
} |
a sample survey of nigerian students conducted by means of a self-administered drug use questionnaire at three universities in the united states of america showed that at some time in their lives 91.2 per cent of the respondents had used alcoholic beverages , 62.3 per cent tobacco , 30.6 per cent cannabis , 6.3 per cen... | NA | {
"id": "C0002667",
"name": "amphetamines",
"pos": [
348,
360
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
364,
375
]
} |
in addition , the results of the survey showed that in the last 12 months before the survey 79.1 per cent of the respondents had used alcoholic beverages , 41.8 per cent tobacco , 2.9 per cent inhalants , 19.2 per cent cannabis , 10.4 per cent amphetamines and amphetamine-type substances , 2.1 per cent cocaine , 1.7 pe... | NA | {
"id": "C0002667",
"name": "amphetamines",
"pos": [
244,
256
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
261,
272
]
} |
the survey also showed that in the last 30 days before the survey 64 per cent of the respondents had used alcoholic beverages , 31.8 per cent tobacco , 2.1 per cent inhalants , 13.9 per cent cannabis , 5.3 per cent amphetamines and amphetamine-type substances , 0.8 per cent cocaine , 1.2 per cent hallucinogens , 2.1 pe... | NA | {
"id": "C0002667",
"name": "amphetamines",
"pos": [
215,
227
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
232,
243
]
} |
[ studies on the co-operative effects of organic pollutants and bacterial endotoxin ( lps ) on mouse liver [ 1 ] . on the simultaneous administration of carbon tetrachloride tris ( 2-chloroethyl ) phosphate or polychlorinated biphenyls with lps ] . | NA | {
"id": "C0014264",
"name": "bacterial",
"pos": [
64,
73
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
241,
244
]
} |
[ studies on the co-operative effects of organic pollutants and bacterial endotoxin ( lps ) on mouse liver [ 2 ] . on the hepatic lysosomal labilization induced by co-administration of carbon tetrachloride and lps ] . | NA | {
"id": "C0014264",
"name": "bacterial",
"pos": [
64,
73
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
210,
213
]
} |
a fraction ( p2b ) , partially purified from human plasma ultrafiltrates , produces the same synergistic response with human retentate in the three cellular systems ( cartilages , fibroblasts , activated lymphocytes ) . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
148,
156
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
180,
191
]
} |
cardiac tissues of isdbb rats had higher activities of cat and gssg-rd and elevated levels of gsh compared with weight-matched control rats . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
63,
67
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
94,
97
]
} |
however , those fed sulfate exhibited significantly less calcium and acid excretion and absorbed a smaller proportion of the anion load than those given chloride . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
20,
27
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
125,
130
]
} |
however , those fed sulfate exhibited significantly less calcium and acid excretion and absorbed a smaller proportion of the anion load than those given chloride . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
125,
130
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
153,
161
]
} |
thus , in chronic feeding trials , there appears to be no measurable difference in the calciuretic properties of sulfate and chloride anions . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
113,
120
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
134,
140
]
} |
thus , in chronic feeding trials , there appears to be no measurable difference in the calciuretic properties of sulfate and chloride anions . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
125,
133
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
134,
140
]
} |
the rank order of each ketone 's ability to modify p-450 parameters was the same in most instances as that based on peak ability to potentiate chcl3-induced hepatotoxicity : 2-hexanone greater than 2-butanone greater than or equal to acetone . | NA | {
"id": "C0022634",
"name": "ketone 's",
"pos": [
23,
32
]
} | {
"id": "C0001002",
"name": "acetone",
"pos": [
234,
241
]
} |
measurement of the arteriovenous differences for free amino acids across rat kidney reveals that glycine and citrulline are removed and serine and arginine are added to the circulation . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
54,
65
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
97,
104
]
} |
urine samples from sympathectomized and control rats , given ethanol , displayed equivalent increases in excreted adrenaline and noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
114,
124
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
129,
142
]
} |
both gnrh analogs elicited dose-dependent ( 0.1-1 nmol.kg-1 ) increases in arterial norepinephrine , epinephrine , and blood pressure levels when injected intravenously into toads . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
84,
98
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
101,
112
]
} |
in bullfrogs , [ trp7 , leu8 ] -gnrh ( 1 nmol.kg-1 ) increased arterial norepinephrine concentration approximately 10-fold without affecting the concentrations of norepinephrine sulfate , norepinephrine glucuronide , epinephrine , epinephrine sulfate , or epinephrine glucuronide . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
72,
86
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
256,
267
]
} |
in bullfrogs , [ trp7 , leu8 ] -gnrh mobilizes norepinephrine but not epinephrine , and the noradrenergic effect is insufficient to raise blood pressure . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
47,
61
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
70,
81
]
} |
blood ionized calcium and sodium concentrations ( b [ ca2+ ] and b [ na+ ] ) were determined by ion-selective electrolyte analysis . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
6,
9
]
} | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
110,
121
]
} |
the actions of 2,6-dimethyl-3,5-dicarbomethoxy-4- ( 2-isothiocyano ) phenyl-1,4- dihydropyridine ( o-ncs-dhp ) , a nifedipine analog bearing a reactive group , have been characterized in vitro by pharmacological and radioligand binding techniques in a number of smooth muscles and in vivo by blood pressure and radioliga... | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
81,
96
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
115,
125
]
} |
microelectrodes filled with this exchanger were used to qualitatively detect changes in intracellular anion in chloride-depleted frog sartorius muscle fibres during exposure to extracellular concentrations of l-lactate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
102,
107
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
111,
119
]
} |
the effect of disulfiram on the 5-lipoxygenase activity from rat polymorphonuclear leukocyte cell-free lysates was determined and compared with that of other thiocarbamoyl and aryl disulfides . | NA | {
"id": "C0012772",
"name": "disulfiram",
"pos": [
14,
24
]
} | {
"id": "C0012771",
"name": "disulfides",
"pos": [
181,
191
]
} |
in the basidiomycete fungus coprinus cinereus , the 5s ribosomal rna ( rrna ) genes are found in the rdna repeat which encodes the other three rrnas ( 18s , 5.8s , and 26s ) , and all genes are transcribed in the same direction ( cassidy et al . 1984 ) . | NA | {
"id": "C0035707",
"name": "5s ribosomal rna",
"pos": [
52,
68
]
} | {
"id": "C0035701",
"name": "rrnas",
"pos": [
143,
148
]
} |
in mutant devoid of core protein i , cytochrome b was found to be reducible by nadh but not by succinate , suggesting two different electron transfer pathways inside comples iii from each substrate to cytochrome b heme ( s ) . | NA | {
"id": "C0010744",
"name": "cytochrome b",
"pos": [
37,
49
]
} | {
"id": "C1256751",
"name": "cytochrome b heme",
"pos": [
201,
218
]
} |
the relative hydrolysis sequence of polysaccharides were amylose greater than soluble starch = corn starch greater than glycogen . | NA | {
"id": "C0002732",
"name": "amylose",
"pos": [
57,
64
]
} | {
"id": "C0038179",
"name": "starch",
"pos": [
100,
106
]
} |
oxidised glutathione and aldehydes were identified as products of the reaction , with unstable glutathione-conjugates being formed as intermediates only . | NA | {
"id": "C0061516",
"name": "oxidised glutathione",
"pos": [
0,
20
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
95,
106
]
} |
we have initiated a series of experiments to determine the potential of cells of the mouse yolk sac to differentiate in vitro , in order to get an insight into the development of immunocompetence in this primary population of hematopoietic stem cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
55,
58
]
} | {
"id": "C0018956",
"name": "hematopoietic stem cells",
"pos": [
226,
250
]
} |
here , the synthesis of low levels of cytokeratins 8 and 18 , sometimes with traces of cytokeratin 19 , has been demonstrated in smooth muscle cells by colocalization with myogenic marker proteins , such as desmin and/or the smooth-muscle-specific isoform of alpha-actin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
188,
196
]
} | {
"id": "C0597298",
"name": "isoform",
"pos": [
248,
255
]
} |
in addition , records were obtained after a single bedtime dose of the benzodiazepine hypnotics flurazepam ( 30 mg ) , flunitrazepam ( 2 mg ) , triazolam ( 0.5 mg ) and midazolam ( 15 mg ) . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
71,
85
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
169,
178
]
} |
thus lambda dcysjihd is a bio-type transducing phage . lambda cysj was shown to have lost very little lambda dna and to carry about 8 kb of bacterial dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
109,
112
]
} | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
140,
153
]
} |
among the anions tested , br- , i- and no3- could replace cl- , but so4 ( 2- ) and ch3coo- could not . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
10,
16
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
32,
33
]
} |
strains carrying the absa mutation also displayed enhanced uptake of a hydrophobic fluorescent probe , 1-n-phenylnaphthylamine , and were found , by sds-page , to be altered in the pattern of lipopolysaccharide o-antigen distribution . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
192,
210
]
} | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
211,
220
]
} |
however , when descriptive diagnosis was taken into consideration , lateralized pain was predominant on the left side in psychogenic headache ( p less than .01 ) , whereas somatogenic headache was more often right-sited . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
80,
84
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
184,
192
]
} |
single i.v . injection of puromycin aminonucleoside ( pm ) dose-dependently increased urinary excretions of ldh and its isoenzymes ( ldh1 = ldh5 greater than ldh2 = ldh4 greater than ldh3 ) , got , nag , acid protease and protein but degree of the increases in these enzymes was lower than those in the rats treated with... | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
120,
130
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
267,
274
]
} |
the region at the n-terminal end of the mature protein ( 39 amino acids ) is primarily composed of alanine , glutamate and proline residues arranged in imperfect repeats with the consensus sequence aaeap . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
60,
71
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
99,
106
]
} |
it also depresses the cholesterol and the trigliceride content in liver homogenates and shows a tendency to normalize the low-density-lipoprotein fraction in guinea-pigs , as well as cholesterol of the high-density lipoprotein fraction , and malon dialdehyde in rabbits . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
22,
33
]
} | {
"id": "C0023822",
"name": "cholesterol",
"pos": [
183,
194
]
} |
incubation of each of the 3 cell lines with [ 1-14c ] arachidonic acid alone or in the presence of phytohemagglutinin ( pha ) , of calcium ionophore a23187 , or of concanavalin a ( con a ) plus the phorbol ester 12-0-tetradecanoylphorbol-13-acetate ( tpa ) failed to generate radiolabelled ltb4 or other eicosanoids as d... | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
198,
211
]
} | {
"id": "C0039654",
"name": "tetradecanoylphorbol",
"pos": [
217,
237
]
} |
the shift in fetal placental pg production from pge 's to pgf 's may be due to a cessation of the ability of released fetal tissue to convert pgf2 alpha to pge2 . | NA | {
"id": "C0033559",
"name": "pge 's",
"pos": [
48,
54
]
} | {
"id": "C0012472",
"name": "pge2",
"pos": [
156,
160
]
} |
the release and absorption profiles from the vagina of pge2 in different vehicles used for cervical ripening and labour induction have been studied observing changes in concentrations of pge metabolite ( pgem ) and pgf metabolite ( pgfm ) . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
55,
59
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
204,
207
]
} |
we have compared the effects of acetyl salicylic acid ( asa , aspirin ) and choline magnesium trisalicylate ( cmt ) , a non-acetylated salicylate product , on platelet aggregation in human whole blood ex-vivo . | NA | {
"id": "C0004057",
"name": "aspirin",
"pos": [
62,
69
]
} | {
"id": "C0036077",
"name": "salicylate product",
"pos": [
135,
153
]
} |
for clarification of the antiviral resistance factor in nu/nu mice , the analysis of antibody other than nt-ab and complement-dependent nt-ab , and the problem of resolution of antibody titration remain . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
85,
93
]
} | {
"id": "C0475463",
"name": "nt-ab",
"pos": [
136,
141
]
} |
bmf from either normal subjects , al at the time of complete remission ( cr ) or cml enhanced the growth of cfu-c in a few spontaneous cfu-c groups ( less than 3 colonies/10 ( 5 ) cells ) , whereas bmf obtained from al at the time of diagnosis failed to enhance the growth . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
180,
185
]
} | {
"id": "C0016030",
"name": "bmf",
"pos": [
198,
201
]
} |
in contrast , bmf from either normal subjects , al at the time of diagnosis and cr , or cml inhibited the growth of cfu-c in many spontaneous cfu-c groups ( greater than 10 colonies/10 ( 5 ) cells ) . | NA | {
"id": "C0016030",
"name": "bmf",
"pos": [
14,
17
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
191,
196
]
} |
these results suggest that , in malawi , amodiaquine and pyrimethamine-sulfadoxine are superior to chloroquine in producing prompt clearance of p. falciparum parasites among young children , and that pyrimethamine-sulfadoxine alone is superior to the 4-aminoquinolines in sustaining p. falciparum clearance . | NA | {
"id": "C0002641",
"name": "amodiaquine",
"pos": [
41,
52
]
} | {
"id": "C0002588",
"name": "aminoquinolines",
"pos": [
253,
268
]
} |
these results suggest that , in malawi , amodiaquine and pyrimethamine-sulfadoxine are superior to chloroquine in producing prompt clearance of p. falciparum parasites among young children , and that pyrimethamine-sulfadoxine alone is superior to the 4-aminoquinolines in sustaining p. falciparum clearance . | NA | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
99,
110
]
} | {
"id": "C0002588",
"name": "aminoquinolines",
"pos": [
253,
268
]
} |
this finding is significant in the pathogenesis of schistosomal liver fibrosis and may also apply to other liver diseases , especially cirrhosis . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
107,
121
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
135,
144
]
} |
the membrane lipid to alkenylresorcinol ratio necessary for initiation of the increase of the erythrocyte membrane permeability for the solutes studied varied from 273 to 82 for glycerol and polyethylene glycol 1000 , respectively , indicating that this strong membrane perturbing action may be primarily responsible for... | NA | {
"id": "C0025249",
"name": "membrane lipid",
"pos": [
4,
18
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
355,
361
]
} |
two of these forms were isolated in homogeneous form : a heavy dimeric form , mr 130,000-142,000 containing 59.6 % of sugars ( including 28.8 % arabinose , 6.9 % galactose , 16.5 % glucose , 1.6 % xylose and 3.1 % mannose ) , and a light monomeric form . of mr 21,000-22,000 , containing 20 % of neutral sugars ( 2.5 % o... | NA | {
"id": "C0003682",
"name": "arabinose",
"pos": [
144,
153
]
} | {
"id": "C0030894",
"name": "pentoses",
"pos": [
322,
330
]
} |
two of these forms were isolated in homogeneous form : a heavy dimeric form , mr 130,000-142,000 containing 59.6 % of sugars ( including 28.8 % arabinose , 6.9 % galactose , 16.5 % glucose , 1.6 % xylose and 3.1 % mannose ) , and a light monomeric form . of mr 21,000-22,000 , containing 20 % of neutral sugars ( 2.5 % o... | NA | {
"id": "C0016945",
"name": "galactose",
"pos": [
162,
171
]
} | {
"id": "C0019494",
"name": "hexoses",
"pos": [
345,
352
]
} |
two of these forms were isolated in homogeneous form : a heavy dimeric form , mr 130,000-142,000 containing 59.6 % of sugars ( including 28.8 % arabinose , 6.9 % galactose , 16.5 % glucose , 1.6 % xylose and 3.1 % mannose ) , and a light monomeric form . of mr 21,000-22,000 , containing 20 % of neutral sugars ( 2.5 % o... | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
181,
188
]
} | {
"id": "C0019494",
"name": "hexoses",
"pos": [
345,
352
]
} |
two of these forms were isolated in homogeneous form : a heavy dimeric form , mr 130,000-142,000 containing 59.6 % of sugars ( including 28.8 % arabinose , 6.9 % galactose , 16.5 % glucose , 1.6 % xylose and 3.1 % mannose ) , and a light monomeric form . of mr 21,000-22,000 , containing 20 % of neutral sugars ( 2.5 % o... | NA | {
"id": "C0043375",
"name": "xylose",
"pos": [
197,
203
]
} | {
"id": "C0030894",
"name": "pentoses",
"pos": [
322,
330
]
} |
two of these forms were isolated in homogeneous form : a heavy dimeric form , mr 130,000-142,000 containing 59.6 % of sugars ( including 28.8 % arabinose , 6.9 % galactose , 16.5 % glucose , 1.6 % xylose and 3.1 % mannose ) , and a light monomeric form . of mr 21,000-22,000 , containing 20 % of neutral sugars ( 2.5 % o... | NA | {
"id": "C0024742",
"name": "mannose",
"pos": [
214,
221
]
} | {
"id": "C0019494",
"name": "hexoses",
"pos": [
345,
352
]
} |
the purified preparation oxidized not only glucose but also d-glucosamine , n-acetylglucosamine and xylose in 87 , 63 and 23 % , respectively . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
62,
73
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
76,
95
]
} |
in addition , immune convalescent dgi serum , which did not exhibit bactericidal activity , was restored to killing by selective immunodepletion of protein iii antibodies . | NA | {
"id": "C0020960",
"name": "immune",
"pos": [
14,
20
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
160,
170
]
} |
polymyxin b neutralized lps-induced damage , suggesting that the lipid a portion of lps was the toxic moiety . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
65,
72
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
84,
87
]
} |
the choice of the radioisotope depends upon the dose distribution around the isotope , energy of the emitted radiation , relative biological effectiveness , and finally , the cost and availability of the isotope . | NA | {
"id": "C0034595",
"name": "radioisotope",
"pos": [
18,
30
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
204,
211
]
} |
the procedure is specifically useful in the following four groups : ( 1 ) tremor-dominant cases , ( 2 ) hemiparkinsonism , ( 3 ) cases with marked asymmetry in motor symptoms and ( 4 ) juvenile parkinsonism presenting levodopa-induced dyskinesia . | NA | {
"id": "C0040822",
"name": "tremor",
"pos": [
74,
80
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
235,
245
]
} |
comparison of these data with respectively those for incorporation of nucleosides into the pyrimidine nucleotides of isolated rat heart and with nucleotide turnover rates in vivo suggests that , under physiological conditions , the utilization of plasma cytidine is crucial to the synthesis of myocardial pyrimidine synt... | NA | {
"id": "C0034288",
"name": "pyrimidine nucleotides",
"pos": [
91,
113
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
145,
155
]
} |
it appears , therefore , that nicardipine at least in part evoked hypothermia through alpha-2 adrenoceptors located presynaptically , while nicardipine-induced respiratory changes are mediated also partly via alpha-adrenoceptors having mixed alpha 1 and alpha 2 properties . | NA | {
"id": "C0001639",
"name": "alpha-2 adrenoceptors",
"pos": [
86,
107
]
} | {
"id": "C0034784",
"name": "alpha-adrenoceptors",
"pos": [
209,
228
]
} |
the organization of rat liver ribosomal dna ( rdna ) as matrix-attached dna loops was examined using a protocol which fractionates chromatin from discrete regions of dna loops . | NA | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
30,
43
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
166,
169
]
} |
southern blot analysis of matrix-attached and solubilized chromatin dna fragments demonstrated that rdna is associated with the matrix via its 5 ' and 3 ' nontranscribed spacer sequences ( nts ) . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
68,
71
]
} | {
"id": "C0012933",
"name": "rdna",
"pos": [
100,
104
]
} |
further , we demonstrated that while the kinetics and extent of nuclease digestion were similar in all regions of the dna loops , the nuclease digestion pattern of bulk nuclear and matrix dna showed a typical nucleosome organization , but the rdna fragments retained with the nuclear matrix did not . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
118,
121
]
} | {
"id": "C0012933",
"name": "rdna",
"pos": [
243,
247
]
} |
complexation of the nucleic acid occurs in all cases in a cooperative manner , so that drug binding favours further binding to double helical dna . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
20,
32
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
142,
145
]
} |
sera of balb/c mice immunized with either trinitrophenyl ( tnp ) coupled to bovine serum albumin ( tnp/bsa ) and freund 's adjuvant or tnp/bsa and tnp coupled to mouse serum albumin ( tnp/msa ) without adjuvant were tested for antibody activity against a panel of antigens : tnp/bsa , dna , actin , myosin , tubulin and ... | NA | {
"id": "C0036774",
"name": "bovine",
"pos": [
76,
82
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
168,
181
]
} |
purified antibodies isolated from both immunized balb/c and mrl/lpr/lpr mice on a dinitrophenol ( dnp ) -lysine immunoadsorbent shared antibody activity against both tnp and dna . | NA | {
"id": "C0012466",
"name": "dinitrophenol",
"pos": [
82,
95
]
} | {
"id": "C0045511",
"name": "dnp",
"pos": [
98,
101
]
} |
production of t suppressor factor specific for the hapten picryl chloride requires both t suppressor cells and an antigen-specific , genetically restricted second signal . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
51,
57
]
} | {
"id": "C0031891",
"name": "picryl chloride",
"pos": [
58,
73
]
} |
we investigated the requirement for activation of t suppressor cells specific for the hapten picryl chloride and the release of hapten-specific t suppressor factor . | NA | {
"id": "C0031891",
"name": "picryl chloride",
"pos": [
93,
108
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
128,
134
]
} |
four monoclonal antibodies ( mab ) which recognize distinct epitopes on saimiri immunoglobulins were successfully used to characterize the protective and non-protective antibodies developed by this experimental host in response to infection by the human malaria parasite plasmodium falciparum . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
5,
26
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
169,
179
]
} |
this prevalence and restricted spectrum of chromosome abnormalities , which included monosomy x , triploidy , gonosomal aneuploidy , trisomies 13 , 18 , and 21 , resembled the prevalence and spectrum found among perinatal deaths and differed both in prevalence and type from those chromosome abnormalities found in spont... | NA | {
"id": "C0008626",
"name": "of chromosome abnormalities",
"pos": [
40,
67
]
} | {
"id": "C0002938",
"name": "aneuploidy",
"pos": [
120,
130
]
} |
the drash syndrome of wilms tumor , glomerulonephritis and male pseudohermaphroditism ( xy gonadal dysgenesis ) , was first reported in 1967 [ drash et al , 1970 ; denys et al , 1967 ] . | NA | {
"id": "C0950121",
"name": "drash syndrome",
"pos": [
4,
18
]
} | {
"id": "C0027708",
"name": "wilms tumor",
"pos": [
22,
33
]
} |
this report and others , which indicate that the syndrome may be present in patients without ambiguous genitalia , lead us to suggest that all girls with wilms tumor should be considered at risk for the drash syndrome . | NA | {
"id": "C0027708",
"name": "wilms tumor",
"pos": [
154,
165
]
} | {
"id": "C0950121",
"name": "drash syndrome",
"pos": [
203,
217
]
} |
in the case of doxorubicin or daunorubicin numerous experimental data have been published , which could provide a rationale to this clinical problem . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
15,
26
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
30,
42
]
} |
sixty-two patients who had postpartum endometritis were treated with clindamycin in combination with either aztreonam or the aminoglycoside gentamicin . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
125,
139
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
140,
150
]
} |
at the onset of a typical headache , the patients took two capsules of their assigned study medication and rated responses over the next four hours in three target symptoms areas : pain , emotional or psychic tension , and muscle contractions or stiffness in the head and neck . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
26,
34
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
181,
185
]
} |
the results suggest that the catabolism of triglycerides in lipoprotein and the reduction in tissue cholesterol increase , and that bunazosin hydrochloride does not adversely affect the lipid component in hypertensive patients with hypercholesterolemia . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
60,
71
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
186,
191
]
} |
radioactively labelled thymidine and iododeoxyuridine have been used to label cells in the basal layer and various labelled amino acids ( glycine , cystine and methionine ) have been used to label the metabolically viable cell layers ( up to and including the granular layer ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
124,
135
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
138,
145
]
} |
a sensitive and versatile radioimmunoassay ( ria ) for insulin was established using human insulin standard , a specific guinea pig anti-insulin antiserum and rabbit anti-guinea pig serum . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
85,
98
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
137,
144
]
} |
in addition to human insulin , porcine , canine , rabbit and bovine insulin can also be determined but not rat or mouse insulin . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
15,
28
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
120,
127
]
} |
the relationship between insulin biosynthesis and proinsulin mrna activity was examined in pancreatic monolayer cultures of the neonatal rat . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
25,
32
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
50,
60
]
} |
however , the addition of 16.7 mm 2-deoxyglucose to the basal medium resulted in a 293 % increase in glucose-induced insulin biosynthesis despite a 16 % drop in the proinsulin mrna activity , and primed a dose-dependent increase of insulin biosynthesis over the concentration range of 0 to 16.7 mm glucose . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
117,
124
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
165,
175
]
} |
the effect of tamoxifen ( ici-46474 ) ( alpha- [ 4- ( beta-n-dimethylamino ethoxy ) -phenyl ] alpha'-ethyl trans stilbene on estrogen cytosolic receptor was observed in different parts of fallopian tube and uterus of rabbits during ovum transport . | NA | {
"id": "C0039286",
"name": "tamoxifen",
"pos": [
14,
23
]
} | {
"id": "C0038333",
"name": "stilbene",
"pos": [
113,
121
]
} |
in this lecture , results of our recent in vitro studies on calcium regulating hormones , thyroid-stimulating hormone , and gastro-intestinal hormones are reviewed . | NA | {
"id": "C0019932",
"name": "hormones",
"pos": [
79,
87
]
} | {
"id": "C0017182",
"name": "gastro-intestinal",
"pos": [
124,
141
]
} |
[ elimination of saccharose from the blood and its renal excretion following transfusion of buffy coat-free erythrocyte concentrates containing disaccharides ] . | NA | {
"id": "C0038636",
"name": "saccharose",
"pos": [
17,
27
]
} | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
144,
157
]
} |
controlled studies were conducted to find out the plasma values of ascorbic acid , dehydroascorbic acid ( dha ) , urinary excretion of ascorbic acid and blood levels of glutathione in patients with viral hepatitis , alcoholic hepatitis , cirrhosis of liver and carcinoma of liver . | NA | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
83,
103
]
} | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
135,
148
]
} |
leucocyte ascorbic acid and dha/aa index were also determined in order to assess the ascorbic acid status of these patients . | NA | {
"id": "C0011177",
"name": "dha",
"pos": [
28,
31
]
} | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
85,
98
]
} |
although monoclonal antibodies have frequently been found to be assay specific , these particular antibodies were found to be equally effective in different immunochemical and biological assay systems . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
9,
30
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
98,
108
]
} |
neuropeptide-like immunoreactivity to antisera raised against leu- and met-enkephalin , vasoactive intestinal peptide ( vip ) , neuropeptide y ( npy ) and substance p ( sp ) have been studied immunohistochemically in middle cervical and stellate ganglia of dogs . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
0,
12
]
} | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
128,
142
]
} |
we present a case report of a patient suffering of severe hypertension and grade iv hypertensive retinopathy according to the keith-wagener classification . | NA | {
"id": "C0020538",
"name": "hypertension",
"pos": [
58,
70
]
} | {
"id": "C0152132",
"name": "hypertensive retinopathy",
"pos": [
84,
108
]
} |
the authors report a case of a 14 years old girl with a bilateral optic neuropathy especially an optic atrophy on the left eye . | NA | {
"id": "C0029132",
"name": "optic",
"pos": [
66,
71
]
} | {
"id": "C0029124",
"name": "optic atrophy",
"pos": [
97,
110
]
} |
results suggest that tp-5 is not the smallest active fragment of thymopoietins , since peptides ( tp-3 and tp-4 ) exhibit similar or higher t-cell membrane activation on e-receptor . | NA | {
"id": "C0080225",
"name": "tp-5",
"pos": [
21,
25
]
} | {
"id": "C0040105",
"name": "thymopoietins",
"pos": [
65,
78
]
} |
the oligopeptides arg-lys-asp ( tp-3 ) , arg-lys-asp-val ( tp-4 ) , and arg-lys-asp-val-tyr ( tp-5 ) considered as the active short fragments of thymopoietin were administered ( lo mg/kg ) to c57b1 mice 24 hours before the intravenous inoculation of lewis lung tumor ( llt ) cells . | NA | {
"id": "C0080225",
"name": "tp-5",
"pos": [
94,
98
]
} | {
"id": "C0040105",
"name": "thymopoietin",
"pos": [
145,
157
]
} |
in the first study lipid and lipoprotein composition of 20 patients with pvd were examined . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
19,
24
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
29,
40
]
} |
the connective tissue space of this cell layer corresponds to the endoneurium , indicating that intermediate layer cells are comparable to endoneurial fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
115,
120
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
151,
162
]
} |
a similar-sized complex was observed , when 3h-hcg ( beta-subunit labeled ) instead of 125i-hcg ( alpha-subunit labeled ) was used , indicating that the complex contains intact hcg . | NA | {
"id": "C0106132",
"name": "hcg",
"pos": [
47,
50
]
} | {
"id": "C0018062",
"name": "125i-hcg",
"pos": [
87,
95
]
} |
a similar-sized complex was observed , when 3h-hcg ( beta-subunit labeled ) instead of 125i-hcg ( alpha-subunit labeled ) was used , indicating that the complex contains intact hcg . | NA | {
"id": "C0018062",
"name": "125i-hcg",
"pos": [
87,
95
]
} | {
"id": "C0017963",
"name": "alpha-subunit",
"pos": [
98,
111
]
} |
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