text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these data indicate that ak-like cells are generated from human pbm cells through mediation of il-1 , il-2 , and ifn-gamma produced by ok-432 in vitro . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
33,
38
]
} | {
"id": "C1321301",
"name": "pbm cells",
"pos": [
64,
73
]
} |
1-dodecanol was also hydroxylated very effectively ( 4.58 nmol/mg microsomal protein/min ) by gerbil liver microsomes , but in general the hydroxylation rates for fatty alcohols were much lower than those for the corresponding acids . | NA | {
"id": "C0023142",
"name": "1-dodecanol",
"pos": [
0,
11
]
} | {
"id": "C0015694",
"name": "fatty alcohols",
"pos": [
163,
177
]
} |
two siblings with congenital hypothyroidism due to total failure to transport iodide have been followed up during twelve and a half years of treatment with oral potassium iodide . | NA | {
"id": "C0021966",
"name": "iodide",
"pos": [
78,
84
]
} | {
"id": "C0032831",
"name": "potassium",
"pos": [
161,
170
]
} |
the neurological manifestations were characterized by a chronic meningitis and symptoms indicating meningeal irritation : headaches , seizures , spasticity of legs . | NA | {
"id": "C0027854",
"name": "neurological manifestations",
"pos": [
4,
31
]
} | {
"id": "C0025287",
"name": "meningeal irritation",
"pos": [
99,
119
]
} |
the percentages for squalene , cholesterol esters , wax esters , triglycerides , free fatty acids , cholesterol and diglycerides were determined . | NA | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
31,
49
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
100,
111
]
} |
side-effects are disturbances of the menstrual cycle ( e.g . breakthrough bleedings ) as well as an amenorrhea after frequent use ( up to 50 % of all cases ) . | NA | {
"id": "C0025345",
"name": "disturbances",
"pos": [
17,
29
]
} | {
"id": "C0002453",
"name": "amenorrhea",
"pos": [
100,
110
]
} |
antigenic mapping of the hn and f proteins using variant viruses in cross neutralization tests revealed the presence of at least two different epitopes on hn and four epitopes on f protein . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
0,
9
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
167,
175
]
} |
the elimination in cow 's milk of polypeptidic antibiotic residues ( colistin sulfate , colistin methanesulfonate and bacitracin ) was investigated following intramuscular and intramammary administrations of eight drugs marketed in france . | NA | {
"id": "C0009317",
"name": "colistin",
"pos": [
69,
77
]
} | {
"id": "C0009316",
"name": "colistin",
"pos": [
88,
96
]
} |
various 3-hydroxy-2-phosphonylmethoxypropyl ( hpmp ) and 2-phosphonylmethoxyethyl ( pme ) derivatives of purine [ adenine ( a ) , guanine ( g ) , 2,6-diaminopurine ( dap ) , 2-monoaminopurine ( map ) , hypoxanthine ( hx ) ] and pyrimidine [ cytosine ( c ) , uracil ( u ) , thymine ( t ) ] have been evaluated for their a... | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
258,
264
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
273,
280
]
} |
of the new compounds tested , the following emerged as the most potent and selective inhibitors of asfv replication : the cyclic phosphonate of ( s ) -hpmpa [ ( s ) -chpmpa ] with an mic of 0.2 microgram/ml and a selectivity index of 2500 , the 2,6-diaminopurine analogue of ( s ) -hpmpa [ ( s ) -hpmpdap ] with an mic o... | NA | {
"id": "C0010843",
"name": "cytosine",
"pos": [
381,
389
]
} | {
"id": "C0286079",
"name": "hpmpc",
"pos": [
399,
404
]
} |
the major plasma lipids , cholesterol and triglyceride , circulate in association with specific proteins as lipid-protein or lipoprotein complexes . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
17,
22
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
125,
136
]
} |
these applications include the diagnosis of coronary artery disease , both acute and chronic , and evaluations of prognosis and therapeutic response in patients with coronary artery disease , valvular heart disease , especially regurgitant lesions , and myopathic heart diseases , particularly dilated and hypertrophic c... | NA | {
"id": "C0018799",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0018824",
"name": "valvular heart disease",
"pos": [
192,
214
]
} |
nineteen patients were analyzed , of whom eight had no overt liver disease , five had active hepatitis , five had cirrhosis , and one had acute cholecystitis . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
61,
74
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
114,
123
]
} |
it was concluded that terbutaline decreased sequestration of platelets in the lungs and in the liver of sheep in endotoxin shock , which may be of importance in the development of multiple organ failure . | NA | {
"id": "C0036974",
"name": "shock",
"pos": [
123,
128
]
} | {
"id": "C0026766",
"name": "multiple organ",
"pos": [
180,
194
]
} |
detection of creatine kinase , which catalyzes the conversion of adp and phosphocreatine to atp and creatine , was performed on the electrocyte of electrophorus electricus ( l. ) using a histoenzymological method based on the formation of blue colored formazan . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
73,
88
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
100,
108
]
} |
transmitters and modulators in these pathways include several neuropeptides , amino acids such as gamma-aminobutyric acid ( gaba ) and glutamate , and biogenic amines such as serotonin , acetylcholine , and dopamine . | NA | {
"id": "C0005496",
"name": "biogenic amines",
"pos": [
151,
166
]
} | {
"id": "C0001041",
"name": "acetylcholine",
"pos": [
187,
200
]
} |
in both intact and permeabilized cells , the plasma membrane metalloproteinase , but not the soluble proteinases , is inhibited by phosphoramidon . | NA | {
"id": "C0025543",
"name": "metalloproteinase",
"pos": [
61,
78
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
101,
112
]
} |
at the time of hospital admission the distinction between reversible ischaemia ( angina ) and myocardial damage ( infarction ) is often difficult . | NA | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
69,
78
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
114,
124
]
} |
21 patients of borderline lepromatous and lepromatous leprosy of both sexes were taken for study after exclusion of autonomic disorders . | NA | {
"id": "C1562585",
"name": "borderline lepromatous",
"pos": [
15,
37
]
} | {
"id": "C0023348",
"name": "lepromatous leprosy",
"pos": [
42,
61
]
} |
intermediate-sized filament proteins ( keratin , vimentin , desmin ) in metaplastic carcinomas , carcinosarcomas and stromal sarcomas of the breast . | NA | {
"id": "C0021769",
"name": "intermediate",
"pos": [
0,
12
]
} | {
"id": "C0010803",
"name": "keratin",
"pos": [
39,
46
]
} |
intermediate-sized filament proteins ( keratin , vimentin , desmin ) in metaplastic carcinomas , carcinosarcomas and stromal sarcomas of the breast . | NA | {
"id": "C0021769",
"name": "intermediate",
"pos": [
0,
12
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
49,
57
]
} |
the distribution of intermediate-filament ( if ) proteins of the keratin , vimentin and desmin type in breast stromal sarcomas , carcinosarcomas , metaplastic carcinomas and phyllodes tumors has been compared using the avidin-biotin complex immunoperoxidase technique . | NA | {
"id": "C0021769",
"name": "intermediate-filament",
"pos": [
20,
41
]
} | {
"id": "C0010803",
"name": "keratin",
"pos": [
65,
72
]
} |
the distribution of intermediate-filament ( if ) proteins of the keratin , vimentin and desmin type in breast stromal sarcomas , carcinosarcomas , metaplastic carcinomas and phyllodes tumors has been compared using the avidin-biotin complex immunoperoxidase technique . | NA | {
"id": "C0021769",
"name": "intermediate-filament",
"pos": [
20,
41
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
75,
83
]
} |
twelve patients ( eight males , four females , mean age 57 years ) with stable effort angina and a positive exercise ecg with angina underwent treadmill exercise testing 2 h after either placebo , or carvedilol 25 or 50 mg . | NA | {
"id": "C0340288",
"name": "stable",
"pos": [
72,
78
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
126,
132
]
} |
s beta 2m was found elevated in the overall population ( 41.4 +/- 10.2 mg/l ) with a 12.5 % variation over time observation in stable patients , not influenced by sex , causal nephropathy , and dialysis mode in anuric patients , beta 2m was inversely correlated with residual diuresis . | NA | {
"id": "C0022658",
"name": "nephropathy",
"pos": [
176,
187
]
} | {
"id": "C0003460",
"name": "anuric",
"pos": [
211,
217
]
} |
the plasma lipolytic and anticoagulant activities following i.v . injection of either standard heparin or low molecular weight heparin ( pk 10169 ) were compared in a study involving 10 healthy volunteers . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
95,
102
]
} | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
106,
134
]
} |
the total lipolytic activity ( lipoprotein lipase + hepatic lipase ) released by pk 10169 was similar to that released by standard heparin when low molecular weight heparin was administered in doses 3- to 5-fold higher ( by weight ) than standard heparin . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
144,
172
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
247,
254
]
} |
in doses where the lipoprotein lipase activities released by the 2 heparins were similar , the hepatic lipase released with low molecular weight heparin was significantly higher than with standard heparin . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
124,
152
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
197,
204
]
} |
this questionnaire was pretested and found to have a sensitivity of 100 percent for detecting epilepsy , febrile seizures ( only in children ) , completed stroke , peripheral neuropathy , movement disorders , cerebral palsy , mental retardation , and severe dementia . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
94,
102
]
} | {
"id": "C0009952",
"name": "febrile seizures",
"pos": [
105,
121
]
} |
exposure of cultured skin fibroblast of normal , infantile nephropathic , juvenile-late-onset and adult type cystinotic patients and their corresponding obligate heterozygotes to 0.5 mmol/l of 35s cystine dimethyl ester for 30 minutes , resulted in an accumulation of cystine within the cells , and was used to look for ... | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
26,
36
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
287,
292
]
} |
these results were compared with those of known anti-epileptic drugs , such as phenytoin , phenobarbital and valproic acid , and it is suggested that be deserves further research as a potential candidate for the treatment of epilepsy . | NA | {
"id": "C3537002",
"name": "anti-epileptic drugs",
"pos": [
48,
68
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
79,
88
]
} |
these results were compared with those of known anti-epileptic drugs , such as phenytoin , phenobarbital and valproic acid , and it is suggested that be deserves further research as a potential candidate for the treatment of epilepsy . | NA | {
"id": "C3537002",
"name": "anti-epileptic drugs",
"pos": [
48,
68
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
109,
122
]
} |
myasthenic thymi presented lower gr values than in normal controls : differences in steroid receptor content observed in the mg thymus as compared to the child thymus may reflect variations in cell populations . | NA | {
"id": "C0034809",
"name": "gr",
"pos": [
33,
35
]
} | {
"id": "C0034840",
"name": "steroid",
"pos": [
84,
91
]
} |
pacemakers isolated from senescent rats showed subsensitivity to the chronotropic effect of isoprenaline and noradrenaline after in vitro inhibition of the catecholamine dissipating mechanisms . | NA | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
92,
104
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
156,
169
]
} |
dose-effect curves for adrenaline and noradrenaline were obtained in the presence and absence of cocaine or corticosterone and the parameter pd2 was determined . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
23,
33
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
38,
51
]
} |
blood and milk concentrations of ampicillin in mothers treated with pivampicillin and in their infants . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
33,
43
]
} | {
"id": "C0032032",
"name": "pivampicillin",
"pos": [
68,
81
]
} |
[ significance of coagulase negative staphylococci on skin-relation to cutaneous infection by staphylococcus aureus : experimental animal infection ] . | NA | {
"id": "C0037278",
"name": "skin",
"pos": [
54,
58
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
138,
147
]
} |
more potent na+/ca2+ exchange inhibitors may have cardiovascular roles as inotropic agents or antagonists of calcium-related injury to cardiomyocytes during reperfusion or other disease states . | NA | {
"id": "C0007220",
"name": "cardiovascular",
"pos": [
50,
64
]
} | {
"id": "C0006684",
"name": "antagonists",
"pos": [
94,
105
]
} |
verapamil , 240 to 360 mg/day , decreased blood pressure and did not impair orthostatic hypotension with a mean follow-up of 6 months . | NA | {
"id": "C0020649",
"name": "decreased blood pressure",
"pos": [
32,
56
]
} | {
"id": "C0020651",
"name": "orthostatic hypotension",
"pos": [
76,
99
]
} |
the rises in plasma renin activity , plasma aldosterone , and plasma adrenaline and noradrenaline concentrations produced by exercise were not significantly affected by felodipine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
69,
79
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
84,
97
]
} |
the natriuretic effect of the dihydropyridine calcium antagonist felodipine : a placebo-controlled study involving intravenous angiotensin ii in normotensive volunteers . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonist",
"pos": [
30,
64
]
} | {
"id": "C0015772",
"name": "felodipine",
"pos": [
65,
75
]
} |
therefore , it was of interest to find the extent to which the specific membrane-associated dihydropyridine ( dhp ) receptors are influenced by salt loading and/or nitrendipine treatment . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
92,
107
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
164,
176
]
} |
the effects of the dihydropyridine derivative nitrendipine and of the phenylalkylamine derivative tiapamil on 45ca2+ influx was determined in platelets in vitro and on platelet aggregation ex vivo . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
19,
34
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
46,
58
]
} |
these responses were not due to a leakage into the systemic circulation , since intravenous injection of gssg or gsh ( 33 nmol ) did not show any cardiovascular effects . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
105,
109
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
113,
116
]
} |
the results indicate that gssg has a stimulatory control over the sympathetic nervous system while gsh has an inhibitory effect on sna . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
26,
30
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
99,
102
]
} |
glutathione disulfide and gsh may act within the central nervous system to modulate the tone of the sympathetic nervous system . | NA | {
"id": "C0061516",
"name": "glutathione disulfide",
"pos": [
0,
21
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
26,
29
]
} |
mean blood pressure ( map ) and plasma beta en , norepinephrine ( ne ) , epinephrine ( e ) , and dopamine ( da ) were measured before and 180 min after an oral dose of 0.3 mg clo . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
49,
63
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
73,
84
]
} |
in comparison to the wky rats , the shr had significantly lower neuropeptide concentrations within the cor ( npy , cck-8 ) , hyp ( nt ) , mo/p ( npy , nt , and cck-8 ) , csc ( all neuropeptides ) , and tsc ( npy , nt , cck-8 , and vip ) . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
180,
193
]
} | {
"id": "C0027893",
"name": "npy",
"pos": [
208,
211
]
} |
in comparison to the wky rats , the shr had significantly lower neuropeptide concentrations within the cor ( npy , cck-8 ) , hyp ( nt ) , mo/p ( npy , nt , and cck-8 ) , csc ( all neuropeptides ) , and tsc ( npy , nt , cck-8 , and vip ) . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
180,
193
]
} | {
"id": "C0027930",
"name": "nt",
"pos": [
214,
216
]
} |
the aim of our study was to evaluate the relationship between ap levels , echocardiographic lvh and 24-h urinary excretion of epinephrine ( ue ) and norepinephrine ( une ) in 23 previously untreated stable hypertensive individuals with lvh and in 18 healthy normotensive control subjects before and after 1-year treatmen... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
126,
137
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
149,
163
]
} |
csf norepinephrine ( ne ) , epinephrine ( epi ) , and dopamine ( da ) levels were measured in 12 normotensive ( age 36 +/- 3 years ; sbp = 116 +/- 4 and dbp = 79 +/- 4 mm hg ) and in 12 eht ( age 41 +/- 2 years ; | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
4,
18
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
28,
39
]
} |
compared to placebo baseline , clonidine ( mean dose 0.4 mg/day ) caused parallel decreases in mean arterial pressure ( map ) ( -8 +/- 2 mm hg , p less than 0.05 ) , heart rate ( hr ) ( -13 +/- 3 b/min , p less than 0.05 ) , plasma ne ( -84 +/- 13 pg/ml , p less than 0.01 ) , and plasma epinephrine ( -24 +/- 4 pg/ml , ... | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
26,
28
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
288,
299
]
} |
changes in the composition of the transmitter , such as the presence of adrenaline as a cotransmitter together with noradrenaline , can result in increased facilitation of transmission . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
72,
82
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
116,
129
]
} |
neuropeptide y is stored in large dense-cored vesicles and coreleased with noradrenaline ( na ) from postganglionic , sympathetic nerves , and with adrenaline ( adr ) from the adrenal medulla . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
75,
88
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
148,
158
]
} |
this may explain reduced release of coexisting neuropeptides such as neuropeptide y ( npy ) in sympathetic nerves , which we have observed following clonidine treatment , since such neuropeptides are particularly effectively released in burst sequences . | NA | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
69,
83
]
} | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
182,
195
]
} |
in contrast to our results in fibroblastic cells , differentiating f9 teratocarcinoma cells down-regulate c-myc expression entirely at the post-transcriptional level . | NA | {
"id": "C0016030",
"name": "fibroblastic cells",
"pos": [
30,
48
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
86,
91
]
} |
cloning of tetradecanoyl phorbol ester-induced 'primary response ' sequences and their expression in density-arrested swiss 3t3 cells and a tpa non-proliferative variant . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
25,
38
]
} | {
"id": "C0039654",
"name": "tpa",
"pos": [
140,
143
]
} |
the bacterially expressed v-myb protein served as antigen for the isolation of several monoclonal antibodies , one of which recognized the human cellular myb protein ( p75hu-c-myb ) indicating a conserved epitope . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
50,
57
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
205,
212
]
} |
the pab1620 antibody belongs to a group of monoclonal antibodies reported to recognize nuclear large t antigen of simian virus 40 ( sv40 ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
12,
20
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
43,
64
]
} |
it has been found that exercise-induced mobilization of glycogen in vastus deepest and soleus was diminished whereas utilization of liver glycogen was accelerated in adrenalectomized rats as compared to sham-operated controls . | NA | {
"id": "C0017911",
"name": "glycogen",
"pos": [
56,
64
]
} | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
132,
146
]
} |
the hemoglobin porto alegre ( hbpa ) disulfide polymer dodecamer and the hbpa , hba disulfide polymer octamer subunit dissociation by nacl was studied by measuring the osmotic pressure of co-hemoglobin solutions at ph = 6.9 and 20 degrees c . | NA | {
"id": "C0019016",
"name": "hba",
"pos": [
80,
83
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
191,
201
]
} |
the effects of normobaric hypoxia ( 10 % o2 ) for 2 , 7 , 14 and 28 days on the dopamine ( da ) , norepinephrine ( ne ) and epinephrine ( e ) dynamics ( content and utilization ) were investigated in carotid bodies , adrenals , heart , kidneys and three sympathetic ganglia . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
98,
112
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
124,
135
]
} |
in vessels precontracted with noradrenaline , almitrine ( added to the nutrient solution of vessels before applying noradrenaline ) potentiated the adenosine-induced initial contractile response without influencing the methylxanthine-sensitive relaxing effect of this purine nucleoside . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
148,
157
]
} | {
"id": "C0034136",
"name": "purine",
"pos": [
268,
274
]
} |
the uptake of a neutral ( glycine ) , an acidic ( l-glutamate ) and a basic ( l-arginine ) amino-acids and of the aldopentose ( d-xylose ) was determined under different values of delta microh+ , which was manipulated by varying the ph of the cell suspension . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
26,
33
]
} | {
"id": "C0002520",
"name": "amino-acids",
"pos": [
91,
102
]
} |
certainly these mites appeared in the present study to be much more ubiquitous than supposed previously and the fact that they seemed to be carriers of allergens and antigens that were different from those of dermatophagoides raises the question as to whether the need for hyposensitization treatment for them has been u... | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
152,
161
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
166,
174
]
} |
we have evaluated three monoclonal antibodies ( f ( ab ' ) 2 fragments ) : a mixture of anti-cea and anti-19.9 antibodies in the investigation of colorectal carcinoma and the antibody oc-125 in ovarian cancer . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
24,
45
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
175,
183
]
} |
among patients positive for anti-hdv there were no significant differences between the initial level of igg and the presence or not of igm anti-hbc during the acute phase of the disease ( respectively patients with co-infection or super-infection ) . | NA | {
"id": "C0275524",
"name": "co-infection",
"pos": [
215,
227
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
237,
246
]
} |
cattle are susceptible to intoxication from feeds contaminated with t-2 toxin , one of the more potent trichothecene mycotoxins , while swine refuse to ingest feed contaminated with t-2 toxin . | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
117,
127
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
186,
191
]
} |
due to the lipophilic nature of these mycotoxins , a biologically active phospholipid was used to stimulate the platelets in the presence and absence of the toxins . | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
38,
48
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
157,
163
]
} |
the mycotoxin t-2 toxin and its major metabolite ht-2 toxin inhibited platelet activating factor-stimulated bovine platelets , suspended in homologous plasma , in a concentration but not time dependent manner . | NA | {
"id": "C0026955",
"name": "mycotoxin",
"pos": [
4,
13
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
54,
59
]
} |
in contrast , the minor metabolite t-2 tetraol had no inhibitory effect on platelet function and had no influence on the responses of t-2 toxin or ht-2 toxin when the mycotoxins were present together in the platelet suspensions . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
138,
143
]
} | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
167,
177
]
} |
cardiac arrhythmia and st segment depression was analyzed with long-term ecg registration ( lter ) in 36 patients with organic dementia aged 69-96 ( mean 84 ) years and 27 patients without dementia or current heart disease aged 68-93 ( mean 83 ) years . | NA | {
"id": "C0003811",
"name": "cardiac arrhythmia",
"pos": [
0,
18
]
} | {
"id": "C0018799",
"name": "heart disease",
"pos": [
209,
222
]
} |
psychotropic agents ( 15.9 % ) , diuretics ( 13.8 % ) and cardiovascular drugs ( 13.7 % ) were the most commonly prescribed drugs in this age group . | NA | {
"id": "C0012798",
"name": "diuretics",
"pos": [
33,
42
]
} | {
"id": "C0007220",
"name": "cardiovascular drugs",
"pos": [
58,
78
]
} |
[ the combination of caroli 's disease , cyst of the choledochus , congenital hepatic fibrosis and renal polykystosis . proposal of a new classification of ectatic biliary dysembryoplasia of the common bile duct . apropos of a case ] . | NA | {
"id": "C0162510",
"name": "caroli 's disease",
"pos": [
21,
38
]
} | {
"id": "C0008340",
"name": "cyst",
"pos": [
41,
45
]
} |
the purpose of this study was to find out whether the technique can be used to demonstrate portal hypertension ( ph ) from liver disease through the evaluation of flow reversal in the veins of the round ligament . | NA | {
"id": "C0020541",
"name": "portal hypertension",
"pos": [
91,
110
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
123,
136
]
} |
interstitial pregnancy is a rare form of ectopic pregnancy that carries a higher morbidity and mortality than other tubal pregnancies . | NA | {
"id": "C1401136",
"name": "interstitial pregnancy",
"pos": [
0,
22
]
} | {
"id": "C0032994",
"name": "tubal pregnancies",
"pos": [
116,
133
]
} |
the current study investigated hostile mood , response style ( repression-sensitization [ rs ] ) , and cardiovascular ( blood pressure and heart rate ) as well as endocrine recovery ( cortisol , norepinephrine , and epinephrine ) from a 10-minute mental task in 57 healthy , adult women . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
195,
209
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
216,
227
]
} |
in an experimental study on hypertensive and healthy subjects , the role of anxiety , sex , and disease for the response of plasma epinephrine ( e ) and norepinephrine ( ne ) to pain ( venipuncture ) and mental stress ( word alliteration ) was investigated . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
131,
142
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
153,
167
]
} |
we used the number of stimulating pulses required for the induction of epileptic afterdischarge ( pulse-number threshold ; pnt ) as an indicator of the seizure generating threshold and the duration of induced seizures ( ad duration ; add ) as an indicator of the seizures . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
71,
80
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
263,
271
]
} |
the marked dependence of igf levels on gh adequacy has led to the development of commercial immunoassays for igf-i ( somatomedin-c ) , and the widespread use of igf-i levels in the evaluation of short stature . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
25,
28
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
161,
166
]
} |
in other children whose growth disorder is not likely to be caused by a disorder in the growth hormone-somatomedin axis , growth increments are occasionally seen on higher hgh doses . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
88,
102
]
} | {
"id": "C0169964",
"name": "hgh",
"pos": [
172,
175
]
} |
children up to three years of age received 100 mg/kg/day and older children 60 mg/kg/day , administered in four divided doses . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
0,
8
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
61,
75
]
} |
antibodies a5a3 , a2e11 , and c1e2 exhibited low cross-reactivity with 18-hydroxycorticosterone and 18-hydroxydeoxycorticosterone and showed no detectable displacement of tritiated aldosterone from the antibodies with cortisol , corticosterone , and related steroids . | NA | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
71,
95
]
} | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
229,
243
]
} |
the enzyme showed nadph-specific flavin reductase activity when fad , fmn or riboflavin was used as an electron acceptor . | NA | {
"id": "C0016388",
"name": "fmn",
"pos": [
70,
73
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
77,
87
]
} |
monoclonal anti-gnrh ( moab ) antibodies generated by using azo-gnrh-tt conjugate were purified by affinity chromatography using azo-gnrh-bsa-sepharose 4b column . | NA | {
"id": "C0003250",
"name": "moab",
"pos": [
23,
27
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
30,
40
]
} |
latent human leukocyte collagenase can be activated by gold thioglucose and gold sodium thiomalate , but not by auranofin . | NA | {
"id": "C0018033",
"name": "gold thioglucose",
"pos": [
55,
71
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
112,
121
]
} |
the determinants of an unfavourable prognosis for asthma seem to be the same as those for other types of occupational asthma due to low molecular weight compounds ( i.e . red cedar asthma ) : long duration of exposure before the onset of asthma , long duration of symptoms before diagnosis , airway obstruction , and dua... | NA | {
"id": "C0264423",
"name": "occupational asthma",
"pos": [
105,
124
]
} | {
"id": "C0004096",
"name": "asthma",
"pos": [
238,
244
]
} |
[ musical systolic murmur produced by oscillation of the systolic anterior motion of the mitral apparatus : relation to the genesis of still 's murmur ] . | NA | {
"id": "C0232257",
"name": "systolic murmur",
"pos": [
10,
25
]
} | {
"id": "C0018808",
"name": "murmur",
"pos": [
144,
150
]
} |
in conclusion , the regular oscillation of the sam may be the source of the musical systolic murmur , and they must be taken into consideration as part of the genesis of still 's murmur . | NA | {
"id": "C0232257",
"name": "systolic murmur",
"pos": [
84,
99
]
} | {
"id": "C0018808",
"name": "murmur",
"pos": [
179,
185
]
} |
we investigated the relationship between parameters of left ventricular diastolic filling using pulsed doppler echocardiography and the a wave ratio of apexcardiography ( acg ) , and then evaluate the characteristic features of diastolic behavior in hypertrophic hearts and in various cardiac diseases . | NA | {
"id": "C0018800",
"name": "hypertrophic hearts",
"pos": [
250,
269
]
} | {
"id": "C0018799",
"name": "cardiac diseases",
"pos": [
285,
301
]
} |
the study population consisted of 68 patients and 25 normal subjects , and included 19 cases of chronic renal failure ( crf ) , 17 cases of ischemic heart disease ( ihd ) , 16 cases of hypertension ( ht ) , six cases of hypertrophic cardiomyopathy , two cases of aortic stenosis , two cases of arrhythmias , and six of o... | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
294,
305
]
} | {
"id": "C0018799",
"name": "cardiac",
"pos": [
325,
332
]
} |
thus , rv systolic function was maintained in the patients with anteroseptal infarction , but contractile reserve deteriorated only in severe septal ischemia . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
77,
87
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
149,
157
]
} |
immunofluorescence studies on cell monolayers prepared from explants confirmed that sp 28-36 is found in the cytoplasm of type ii cells but not in fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
30,
34
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
147,
158
]
} |
hence , intron 1 interrupts the coding region of the bioactive portion of grp between the first and second nucleotides for gly , the 24th amino acid of grp . | NA | {
"id": "C0017890",
"name": "gly",
"pos": [
123,
126
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
138,
148
]
} |
2 ) that , after patch excision , the active state of the ligand-stimulated channel is dependent on gtp in the bath , is abolished by treatment of the cytoplasmic face of the patch with activated ptx and nad+ , and after inactivation by ptx , is restored in a gtp-dependent manner by addition of a nonactivated human ery... | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
100,
103
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
523,
534
]
} |
as well as providing a convenient means to access data on individual antibodies and the antigens identified by the workshop ( designated as 'clusters of differentiation ' or cd antigens ) , it can be used to help characterize and identify new monoclonal antibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
69,
79
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
243,
264
]
} |
a solution hybridization assay for ribosomal rna from bacteria using biotinylated dna probes and enzyme-labeled antibody to dna : rna . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
35,
48
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
130,
133
]
} |
nfs were probed biochemically and histochemically , using a large and well-characterized library of monoclonal antibodies that included antibodies that are monospecific for each of the rat nf protein subunits ( nf-h , nf-m , and nf-l ) as well as antibodies that recognized differential phosphorylated states of rat nf-h... | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
100,
121
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
247,
257
]
} |
those fractures with minimal to moderate posteromedial comminution are probably best managed by anatomic reduction and compression hip screw fixation . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
6,
15
]
} | {
"id": "C0476171",
"name": "comminution",
"pos": [
55,
66
]
} |
in this paper , we demonstrate that these proteins are actually subunits of a larger protein having a molecular weight of 180,000 daltons . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
42,
50
]
} | {
"id": "C0599220",
"name": "subunits",
"pos": [
64,
72
]
} |
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