text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in the present studies , angiotensin ii has also been removed from di rats by the administration of an inhibitor ( captopril , sq 14225 ; d-2-methyl-3-mercaptopropanoyl-l-proline ) of the enzyme which converts angiotensin i , the relatively inert component of the renin-angiotensin system , to angiotensin ii , the biolo... | NA | {
"id": "C0006938",
"name": "captopril",
"pos": [
115,
124
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
171,
178
]
} |
comparison of the human mitochrondial dna sequence of the cytochrome oxidase subunit ii gene and the sequence of the corresponding beef heart protein shows that uga is used as a tryptophan codon and not as a termination codon and suggests that aua may be a methionine and not an isoleucine codon . | NA | {
"id": "C0242611",
"name": "termination codon",
"pos": [
208,
225
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
290,
295
]
} |
as a cultured fibroblast moves , particles or pieces of debris attached to its surface move backwards with respect to both the cell and the substrate1,2 , as also do concanavalin a ( con a ) receptors in the membrane of the leading lamella3 . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
14,
24
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
127,
131
]
} |
we support this conclusion with morphological and physiological evidence and relate our findings to the conservation of biological antifreeze necessary for life in ice-laden polar waters . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
164,
167
]
} | {
"id": "C0043047",
"name": "waters",
"pos": [
180,
186
]
} |
the labelled ligand is stereospecifically displaced by the isomers of propranolol and the order of potency of agonists is : isoprenaline greater than adrenaline greater than noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
150,
160
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
174,
187
]
} |
in order to study the effects of the protein moiety independent of the protein-iron complex in the development of ferritin-induced glomerulonephritis , we compared the effects of ferritin , equimolar amounts of apoferritin , and equimolar amounts of iron dextran in swiss albino mice . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
79,
83
]
} | {
"id": "C0022092",
"name": "iron dextran",
"pos": [
250,
262
]
} |
these lesions of the more proximal intrarenal arteries were associated with occlusive lesions of the interlobular arteries , areas of cortical ischaemia and cortical infarcts consistent with the changes resulting from microemboli . | NA | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
143,
152
]
} | {
"id": "C0021308",
"name": "infarcts",
"pos": [
166,
174
]
} |
in 25 patients with end-stage renal failure and 9 patients treated with hemodialysis an increase in norepinephrine ( ne ) and epinephrine ( e ) concentrations in the plasma and a decrease in the dopamine-beta-hydroxylase ( dbh ) activity was ascertained . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
100,
114
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
126,
137
]
} |
the prognosis appears to be linked : -- to an early diagnosis -- to whether or not the hemorrhage is of massive nature or not -- to the precise location of the hematoma -- to the neurological state of the patient at the time of treatment -- to the absence of an associated pathologie ( severe prematurity , coagulation p... | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
87,
97
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
160,
168
]
} |
high incidence of positive results were obtained in germinomas ( 60.9 % ) , ependymomas ( 50.0 % ) , medulloblastomas ( 40.0 % ) , followed by malignant lymphomas ( 20.0 % ) , pontine gliomas ( 16.7 % ) and metastatic tumors ( 16.7 % ) . | NA | {
"id": "C0014474",
"name": "ependymomas",
"pos": [
76,
87
]
} | {
"id": "C0017638",
"name": "gliomas",
"pos": [
184,
191
]
} |
high incidence of positive results were obtained in germinomas ( 60.9 % ) , ependymomas ( 50.0 % ) , medulloblastomas ( 40.0 % ) , followed by malignant lymphomas ( 20.0 % ) , pontine gliomas ( 16.7 % ) and metastatic tumors ( 16.7 % ) . | NA | {
"id": "C0025149",
"name": "medulloblastomas",
"pos": [
101,
117
]
} | {
"id": "C0017638",
"name": "gliomas",
"pos": [
184,
191
]
} |
this study examined alterations in episodic lh release in response to prolonged , slow infusions of dopamine ( da ) , norepinephrine ( ne ) , or epinephrine ( epin ) into the thire ventricle in adult , ovariectomized ( ovx ) rats , and the influence of priming with ovarian steroids on the lh response to the catecholami... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
118,
132
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
145,
156
]
} |
in vitro incubation studies with testosterone , human chorionic gonadotropin ( hcg ) and follicle-stimulating hormone ( fsh ) indicated that both gonadotropins increased the endogenous accumulation of testosterone ( p less than 0.05 ) and the rate of conversion of testosterone to androstenedione ( p less than 0.025 ) . | NA | {
"id": "C0018062",
"name": "human chorionic",
"pos": [
48,
63
]
} | {
"id": "C0018061",
"name": "gonadotropins",
"pos": [
146,
159
]
} |
since oxytalan fibers have been found embedded in bone in the periodontal ligament , the finding of these fibers in the calcified material of peripheral odontogenic fibromas adds considerable weight to the assumption that these lesions are of periodontal ligament origin . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
89,
96
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
192,
198
]
} |
irrespective of their origin ( healthy or pathologic ) , the elastin samples all revealed the same amino acid composition with a very high alanine content in the cross-linking peptides . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
99,
109
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
139,
146
]
} |
in contrast to the findings in older children , penicillin or penicillin analogues and aminoglycosides were the only antimicrobial drug groups administered to neonataes . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
87,
102
]
} | {
"id": "C1136254",
"name": "antimicrobial drug",
"pos": [
117,
135
]
} |
amoxicillin ( 25 mg/kg ) and ampicillin ( 25 mg/kg ) were compared in cross-over fashion in 11 children . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
0,
11
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
29,
39
]
} |
plasma lactate , epinephrine and norepinephrine concentrations following exercise did not differ between the two conditions . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
17,
28
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
33,
47
]
} |
all areas exhibited heavy soil concentrations of organochlorine pesticides including sigma ddt , aldrin , dieldrin , photodieldrin , chlordane , heptachlor , heptachlor epoxide , endrin , endrin ketone , and endosulfan sulfate . | NA | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
145,
155
]
} | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
158,
176
]
} |
in 12 cases , infectious episodes ( 10 septicaemias and two localized infections ) and transplant failure were closely related . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
14,
24
]
} | {
"id": "C0016397",
"name": "localized infections",
"pos": [
60,
80
]
} |
the 33 infected children were divided into three groups on the basis of clinical and bacteriological criteria ( dysuria , frequency , fever , abdominal pain , inflammatory syndrome , immunofluorescence of bacteriuria , serum antibody levels ) : -- group a ( 8 children ) : upper urinary infection -- group b ( 14 childre... | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
205,
216
]
} | {
"id": "C0042029",
"name": "urinary infection of",
"pos": [
379,
399
]
} |
our results indicate that the above mentioned authors have been using in their farr test a preparation of ds dna contaminated by ss dna , thus revealing the presence of anti ss dna ab but not anti ds dna ab , in the sera of their patients . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
17,
18
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
200,
203
]
} |
the artificial endocrine pancreas is a bedside device capable of maintaining blood sugar value within a normal range by the administration of adequate amounts of insulin or glucose given at the optimal time . | NA | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
77,
88
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
173,
180
]
} |
on the contrary patients with a non decompensated cirrhosis had infection mostly with gram-positive organisms ( 82 % ) and foci of infection ( skin , throat ) were documented in 38 % of the cases . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
64,
73
]
} | {
"id": "C0016397",
"name": "foci of infection",
"pos": [
123,
140
]
} |
two unusual phenotypes were observed : phenotype 6-1 for adenosine deaminase and phenotype 3-1 for transaminase gpt . | NA | {
"id": "C0001899",
"name": "1",
"pos": [
51,
52
]
} | {
"id": "C0002594",
"name": "transaminase",
"pos": [
99,
111
]
} |
also , in contrast to eb , dapi forms much weaker fluorescent complexes with single-stranded dna than with ds dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
77,
96
]
} | {
"id": "C0012854",
"name": "ds dna",
"pos": [
107,
113
]
} |
analyses of sequence complexities , stage specific gene expression , and mrna sequence divergence require polysomal rna preparations relatively free of nuclear rna contamination . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
74,
77
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
152,
163
]
} |
the obtained single stranded dna highly enriched for trna complementary sequences was hybridized with total dna from nucleosome monomers ( 140 -- 190 base pairs in size ) and the excess of non hybridized monomer nucleosome dna removed by sepharose 4b chromatography . | NA | {
"id": "C0012935",
"name": "single stranded dna",
"pos": [
13,
32
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
223,
226
]
} |
the sequestered dna molecules are efficiently protected against exogenous deoxyribonuclease action although nicking and linearization of circular dna can be observed . | NA | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
16,
29
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
137,
149
]
} |
the evaluation of the electrostatic molecular potential at important nucleophilic sites of the purine and pyrimidine bases in poly ( dg.dc ) and poly ( da.dt ) and of the evolution of the potential through the series free bases-nucleosides-nucleotides-single polynucleotide helices-double helices enables the interpretat... | NA | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
240,
251
]
} | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
259,
273
]
} |
in dna of the dinoflagellate c. cohnii , the sequence c-mec-g-g apparently renders hpa ii ( c-c-g-g ) incapable of digesting whole cell dna in general , and rdna in particular . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
3,
6
]
} | {
"id": "C0012933",
"name": "rdna",
"pos": [
157,
161
]
} |
msp i , which also recognizes c-c-g-g but cleaves irrespective of methylation , degrades c. cohnii dna and produces rdna segments of 10.2 to 1.4 kb . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
99,
102
]
} | {
"id": "C0012933",
"name": "rdna",
"pos": [
116,
120
]
} |
a single 20-22s rna species about 2-3 times larger than pgh mrna was detected in nuclear rna from gh3 cells labeled for 5 min . with 3h-uridine . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
16,
19
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
81,
92
]
} |
this procedure is demonstrated with two rna molecules of known sequence : 5.8s rrna from yeast ( 158 nucleotides ) and satellite tobacco necrosis virus ( stnv ) rna ( 1240 nucleotides ) . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
79,
83
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
161,
164
]
} |
the synthetic operator containing a guanine-cytosine base pair displays an eightfold reduction in stability with lac repressor whereas the operator containing 5-methylcytosine binds repressor at least as tightly as does the wild type sequence . | NA | {
"id": "C0010843",
"name": "cytosine",
"pos": [
44,
52
]
} | {
"id": "C0049308",
"name": "5-methylcytosine",
"pos": [
159,
175
]
} |
results published previously have shown that a similar decrease in stability of the repressor-operator complex can be obtained simply by substituting uracil for thymine or by inverting the base pair to thymine-adenine . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
150,
156
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
202,
209
]
} |
this dna component which was termed rat satellite dna i is composed of tandemly repeated 370 bp blocks . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
5,
8
]
} | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
40,
53
]
} |
comparative studies of free ribosomal rna and ribosomes were made with two probes , mg++ ions and ethidium bromide , which interact with rna in different ways . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
28,
41
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
137,
140
]
} |
intravenous infusion of noradrenaline ( na ) ( 30 micrograms/kg ) results in reflectory increase of adrenaline ( a ) , this has been established by spectrofluorometrical assay of the difference in the plasma catecholamine level during noradrenalinemia with and without elimination of circulatory reflexes . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
24,
37
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
238,
248
]
} |
serotonin ( 5-ht ) agonists , l-tryptophan or 5-hydroxytryptophan and a mao inhibitor , pargyline , suppressed the apo-induced aggressiveness . | NA | {
"id": "C0041249",
"name": "l-tryptophan",
"pos": [
30,
42
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
46,
65
]
} |
it was found that each di rna arises from a specific segment of standard viral rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
26,
29
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
73,
82
]
} |
antibody and protein a can be removed with urea and 2-mercaptoethanol , and the same paper can be probed again with a different antiserum . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
128,
137
]
} |
purification and distribution of a major protein in rat prostate that binds estramustine , a nitrogen mustard derivative of estradiol-17 beta . | NA | {
"id": "C0014921",
"name": "estramustine",
"pos": [
76,
88
]
} | {
"id": "C0014912",
"name": "estradiol-17 beta",
"pos": [
124,
141
]
} |
a protein in rat ventral prostate cytosol that binds estramustine [ estradiol 3-bis ( 2-chloroethyl ) carbamate ) was purified to homogeneity by using chromatography on deae-cellulose , sephadex g-100 ( superfine ) , octyl-sepharose ( cl-4b , and polyacrylamide gel electrophoresis . | NA | {
"id": "C0014921",
"name": "estramustine",
"pos": [
53,
65
]
} | {
"id": "C0014912",
"name": "estradiol",
"pos": [
68,
77
]
} |
intracellular pool measurements and systematic alteration of perfusate amino acid composition indicated that the autophagic and proteolytic effects of glucagon are mediated by a hormonally induced depletion of glycine , alanine , glutamate , and glutamine ; | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
71,
81
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
210,
217
]
} |
intracellular pool measurements and systematic alteration of perfusate amino acid composition indicated that the autophagic and proteolytic effects of glucagon are mediated by a hormonally induced depletion of glycine , alanine , glutamate , and glutamine ; | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
71,
81
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
220,
227
]
} |
addition of 10 vol of methanol , ethanol , or ethylene glycol to short-term incubations ( 30-45 sec ) led to the formation of the corresponding 12-o-alkyl derivatives of the 5,12-dihydroxy acids . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
22,
30
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
33,
40
]
} |
bovine galactosyltransferase ( lactose synthase ; ec 2.4.1.22 ) which catalyzes the transfer of galactose from udpgalactose to glycoproteins with n-acetylglucosamine as the terminal residue of their oligosaccharide side chains was used to label glycoproteins of mouse retina with [ 14c ] galactose . | NA | {
"id": "C0016964",
"name": "galactosyltransferase",
"pos": [
7,
28
]
} | {
"id": "C0022952",
"name": "lactose synthase",
"pos": [
31,
47
]
} |
i have identified those 5 positions of thymines in the lac uv5 promoter that lie close to bound escherichia coli rna polymerase ( nucleosidetriphosphate : rna nucleotidyltransferase , ec 2.7.7.6 ) . | NA | {
"id": "C0035681",
"name": "rna polymerase",
"pos": [
113,
127
]
} | {
"id": "C0035673",
"name": "rna",
"pos": [
155,
158
]
} |
nucleosome core particles have been efficiently assembled in vitro by direct interaction of histones and dna at physiological ionic strength , as assayed by digestion with dnases , supercoiling of relaxed circular dna , and electron microscopy . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
105,
108
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
205,
217
]
} |
although fluorescein bleaching accompanies the formation of protein aggregates , the amount of aggregated protein is not simply a function of the number of fluoresceins bleached . | NA | {
"id": "C0060520",
"name": "fluorescein",
"pos": [
9,
20
]
} | {
"id": "C0016314",
"name": "fluoresceins",
"pos": [
156,
168
]
} |
nonglycosylated fibronectin that was isolated from chicken embryo fibroblasts and added to transformed cells in vitro was as effective as the glycosylated protein in promoting a more normal fibroblastic phenotype , including cell flattening , elongation of cell processes , and parallel alignment of cells . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
190,
202
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
300,
305
]
} |
amino acid analysis of their cyanogen bromide fragment 3 ( gamma cb3 ) identifies these fractions as the separated g gamma ( gly-136 ) and a gamma ( ala-136 ) globin chains . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
125,
128
]
} |
fingerprint and amino acid analyses of the gamma tp9 tryptic peptide from the purified a gamma and g gamma fractions from two different patients demonstrate that the commonly occurring gamma sardinia variant ( gamma 75 isoleucine leads to threonine ) , also known as t gamma chain , has alanine in position 136 . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
16,
26
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
287,
294
]
} |
in its restriction to a single leukemia , the rl male 1 antigen resembles the individually distinct antigens of chemically induced tumors and other tumor types of rodents . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
56,
63
]
} | {
"id": "C0003335",
"name": "antigens",
"pos": [
100,
108
]
} |
the precursors -- namely , progesterone , pregnenolone , 17 alpha-progesterone , 17 alpha-hydroxypregnenolone , androstenedione , and dehydroepiandrosterone -- caused a 2- to 3 1/2-fold enhancement of guanylate cyclase activity in rat liver , kidney , skeletal muscle , and ventral prostate at a concentration of 1 micro... | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
42,
54
]
} | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
81,
109
]
} |
testosterone , 19-nortestosterone , 17-methyltestosterone , and 5 alpha-dihydrotestosterone enhanced guanylate cyclase activity 2- to 5-fold in the same tissues at 1 microm . | NA | {
"id": "C0039601",
"name": "testosterone",
"pos": [
0,
12
]
} | {
"id": "C0025826",
"name": "17-methyltestosterone",
"pos": [
36,
57
]
} |
other amino acids tested ( leucine , isoleucine , valine , alanine , arginine , and aspartate ) do not affect blood pressure . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
6,
17
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
59,
66
]
} |
that tyrosine 's antihypertensive action is mediated by an acceleration in norepinephrine or epinephrine release within the central nervous system is suggested by the concurrent increase that its injection produces in brain levels of methoxyhydroxyphenylethylglycol sulfate . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
75,
89
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
93,
104
]
} |
the enzyme gave a single stained band on alkaline disc gel electrophoresis which corresponded in location with the kinin-generating activity eluted from a replicate gel , was of 54,000 molecular weight by gel filtration , was devoid of caseinolytic activity , elicited a monospecific antiserum in a rabbit , and gave a l... | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
284,
293
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
468,
476
]
} |
although the chemical structure of the proinsulin cleavage products has not been established , human pancreatic kallikrein is considered a putative activator of proinsulin because of its location in the beta-cell , its preferential action on proinsulin and kininogen as compared to azocasein , and its capacity to genera... | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
39,
49
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
323,
330
]
} |
freshly isolated sarcoplasmic reticulum vesicles contain 0.05 mol of tightly bound adp and 0.03 mol of tightly bound atp per mol of ca2+ , mg2+-atpase ( atp phosphohydrolase , ec 3.6.1.3 ) . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
139,
142
]
} | {
"id": "C0001473",
"name": "atp",
"pos": [
153,
156
]
} |
when deoxycoformycin was added to the defined growth medium containing hypoxanthine as the purine source , the growth of c. fasciculata was unaffected , but when adenine was the purine source for the organism , severe inhibition resulted . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
162,
169
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
178,
184
]
} |
these results provide evidence that ( 32 ) p is incorporated into o-phosphoserine or o-phosphothreonine residues of acceptor proteins , indicating that the enzymatic activity is characteristic for protein kinase , and that cell-specified nuclear proteins other than histones may serve as substrates for the enzyme . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
125,
133
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
238,
254
]
} |
these results provide evidence that ( 32 ) p is incorporated into o-phosphoserine or o-phosphothreonine residues of acceptor proteins , indicating that the enzymatic activity is characteristic for protein kinase , and that cell-specified nuclear proteins other than histones may serve as substrates for the enzyme . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
238,
254
]
} | {
"id": "C0019652",
"name": "histones",
"pos": [
266,
274
]
} |
the amino-terminal sequences of peptides from another bacterial surface protein , staphylococcal protein a , are highly correlated with segments of two other myofibrillar proteins , rabbit actin ( p less than 10 ( -7 ) ) and rabbit myosin a1 light chain ( p less than 10 ( -6 ) ) . | NA | {
"id": "C0004627",
"name": "bacterial",
"pos": [
54,
63
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
171,
179
]
} |
when histone-dna complexes were assembled in vitro from relaxed circular dna , nearly physiological numbers of superhelical turns were induced in the dna molecule . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
64,
76
]
} | {
"id": "C0012854",
"name": "dna molecule",
"pos": [
150,
162
]
} |
because more alpha than beta subunit of thyrotropin was consistently synthesized , unbalanced amounts of thyrotropin subunits appear to be synthesized by translation of unbalanced amounts of individual mrnas . | NA | {
"id": "C0076641",
"name": "beta subunit",
"pos": [
24,
36
]
} | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
105,
116
]
} |
although the overall turnover of surface proteins was biphasic in nature , the rapid phase of protein loss was largely due to low molecular weight species . | NA | {
"id": "C0025252",
"name": "surface proteins",
"pos": [
33,
49
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
94,
101
]
} |
the use of restriction endonuclease digestion , transfer to nitrocellulose filters , and hybridization of the virus-specific dna has produced strong evidence that viral dna sequences present in total 1670 cell dna and in isolated episomes are extensively methylated . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
163,
172
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
210,
213
]
} |
coexistence of desmin and the fibroblastic intermediate filament subunit in muscle and nonmuscle cells : identification and comparative peptide analysis . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
30,
42
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
97,
102
]
} |
membrane vesicles isolated from nontransformed balb/c 3t3 mouse fibroblasts ( 3t3 ) and from those cells transformed by simian virus 40 ( sv3t3 ) displayed carrier-mediated and stereospecific uptake of hexose as measured by the difference between d- [ ( 14 ) c ] glucose or its analogues and l- [ ( 3 ) h ] glucose uptak... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
64,
75
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
99,
104
]
} |
our results indicate that xeroderma pigmentosum fibroblasts have higher uv-induced mutation frequencies per unit uv dose but similar frequencies per unit survival compared to normal cells within the range of uv doses tested . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
48,
59
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
175,
187
]
} |
membrane proteins of lstra or el4 tumor cells ( as source of h-2 antigens ) , human eye muscle membrane proteins ( as supporting proteins ) , and 51cr marker were inserted into the lipid vesicles . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
0,
17
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
129,
137
]
} |
the most prominent change is the loss of the major glycoprotein band typical for the blast cells which has an apparent molecular weight of 160,000 and the appearance of a major surface glycoprotein band with an apparent molecular weight of 130,000 . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
51,
63
]
} | {
"id": "C0025248",
"name": "surface glycoprotein",
"pos": [
177,
197
]
} |
in these characteristics mouse saa closely resembles human saa and the behavior of the protein related to amyloid protein aa indicates that is one of the apoproteins of the hdl complex in both species . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
87,
94
]
} | {
"id": "C0003601",
"name": "apoproteins",
"pos": [
154,
165
]
} |
labeling lung slices or cells with [ ( 3 ) h ] choline for up to 8 hr failed to reveal a significant amount of labeled phosphatidylcholine in the medium of either system compared to the medium from liver slice or fibroblast controls . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
24,
29
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
213,
223
]
} |
anions such as chloride , iodide and nitrite also enhance ( 3h ) diazepam binding and this enhancement is consistent with their role in postsynaptic inhibition . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
0,
6
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
15,
23
]
} |
anions such as chloride , iodide and nitrite also enhance ( 3h ) diazepam binding and this enhancement is consistent with their role in postsynaptic inhibition . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
0,
6
]
} | {
"id": "C0021966",
"name": "iodide",
"pos": [
26,
32
]
} |
anions such as chloride , iodide and nitrite also enhance ( 3h ) diazepam binding and this enhancement is consistent with their role in postsynaptic inhibition . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
0,
6
]
} | {
"id": "C0028137",
"name": "nitrite",
"pos": [
37,
44
]
} |
the effects on active social interaction of acute and chronic dosage with diazepam ( 1 mg/kg ) , desmethyldiazepam ( 2 mg/kg ) , and chlor-desmethyl-diazepam ( 0.125 mg/kg ) were studied in pairs of mice . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
74,
82
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
97,
114
]
} |
two of the drugs , diazepam and desmethyldiazepam , showed an anxiolytic action , i.e. , these drugs resulted in significantly less variation in social interaction with the change in light levels , compared with vehicle-injected controls . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
19,
27
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
32,
49
]
} |
both opiate peptides and morphine caused the inhibition of tail-flick response and catalepsy in rats . beta-endorphin was the most potent , followed by [ d-ala2 , d-leu5 ] -enkephalin and then by morphine . | NA | {
"id": "C0205753",
"name": "opiate peptides",
"pos": [
5,
20
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
173,
183
]
} |
changes indicative of retroperitoneal bleeding were depicted by ct in all 20 patients despite the predominantly small size of the hematomas . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
38,
46
]
} | {
"id": "C0018944",
"name": "hematomas",
"pos": [
130,
139
]
} |
anatomic-pathologic correlation , comparative ct scans and clinical follow-up studies showed subserosal edema and necrosis to be the most probable cause of this finding . | NA | {
"id": "C0013604",
"name": "edema",
"pos": [
104,
109
]
} | {
"id": "C0037088",
"name": "finding",
"pos": [
161,
168
]
} |
the results show that experimental small-bowel infarction can be detected as early as five hours after the onset of ischemia . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
47,
57
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
116,
124
]
} |
the systematic pathological study of 500 patients with intracranial hemorrhages ( ich ) [ 341 ( 68 p. 100 ) cerebral hemorrhages ( c.h . ) ; 119 ( 24 p. 100 ) meningeal hemorrhages ( m.h . ) ; 39 ( 7,8 p. 100 ) subdural hematomas ( s.h . ) and , at last , one extradural hematoma ] has been practiced . | NA | {
"id": "C0151699",
"name": "intracranial hemorrhages",
"pos": [
55,
79
]
} | {
"id": "C2937358",
"name": "cerebral hemorrhages",
"pos": [
108,
128
]
} |
hydralazine and dihydralazine , chelators of fe2+ , fe3+ and mn2+ ions , inhibited collagen biosynthesis in organ culture of chicken embryo tibiae . | NA | {
"id": "C0020223",
"name": "hydralazine",
"pos": [
0,
11
]
} | {
"id": "C0012271",
"name": "dihydralazine",
"pos": [
16,
29
]
} |
as additional symptoms of pollen allergy due to haematogenous spread of the pollen antigens we observed a seasonal form of atopic dermatitis in 3 % , a seasonal urticaria or angioedema in 3.5 % , migraine in 6.3 % and arthralgia , gastro-intestinal troubles and fever in fewer than 1 % each . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
161,
170
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
174,
184
]
} |
sixty-eight patients with various connective tissue disorders , 5 relatives of patients and 26 members of staff from the centre for rheumatic diseases were studied for the presence in their sera of cold lymphocytotoxic antibodies . | NA | {
"id": "C0009782",
"name": "connective tissue disorders",
"pos": [
34,
61
]
} | {
"id": "C0035435",
"name": "rheumatic diseases",
"pos": [
132,
150
]
} |
the efficacy of 3 g of amoxicillin plus 1 g of probenecid was compared with the efficacy of 3.5 g of ampicillin plus 1 g of probenecid for the treatment of uncomplicated gonorrhea . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
23,
34
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
101,
111
]
} |
in several instances , primed lymphocytes responded significantly to allogeneic stimulators negative for the specific hla-d and/or hla-dr specificities . | NA | {
"id": "C0019754",
"name": "hla-d",
"pos": [
118,
123
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
131,
137
]
} |
associations were examined between different types of sperm antibody , and between these antibodies and autoantibodies to other antigens . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
89,
99
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
104,
118
]
} |
in the ms patient group , a much weaker association was noted between bfs and hla-b7 suggesting either that the bf locus is musch closer to the hla-d than the hla-b locus or ( and ) that hla-d and bf products selectively interact ( perhaps on the surface of b lymphocytes ) with evolutionary advantage or disadvantage re... | NA | {
"id": "C0019744",
"name": "hla-b7",
"pos": [
78,
84
]
} | {
"id": "C0019737",
"name": "hla-b",
"pos": [
159,
164
]
} |
phenobarbital increased the oxidative pathway of progesterone metabolism ( formation of 6 beta- , 16 alpha- , 20 alpha-hydroxyprogesterone ) but the reductive pathway remained unaltered ( formation of pregnanediol , pregnanolone ) . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
49,
61
]
} | {
"id": "C0012311",
"name": "20",
"pos": [
110,
112
]
} |
phenobarbital increased the oxidative pathway of progesterone metabolism ( formation of 6 beta- , 16 alpha- , 20 alpha-hydroxyprogesterone ) but the reductive pathway remained unaltered ( formation of pregnanediol , pregnanolone ) . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
49,
61
]
} | {
"id": "C0033004",
"name": "pregnanediol",
"pos": [
201,
213
]
} |
the results support the suggestions that cyanide affects bodily handling of cbl and that hydroxo-cobalamin plays a part in detoxication of cyanide . | NA | {
"id": "C0042845",
"name": "cbl",
"pos": [
76,
79
]
} | {
"id": "C0020316",
"name": "hydroxo-cobalamin",
"pos": [
89,
106
]
} |
these data also suggested that in normal rats the kidneys are the major route of elimination of citrinin and its metabolite ( s ) while in rats rendered nephrotoxic by citrinin pretreatment , elimination is more dependent on hepatic excretion . | NA | {
"id": "C1373186",
"name": "route of elimination",
"pos": [
72,
92
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
192,
203
]
} |
these data also suggested that in normal rats the kidneys are the major route of elimination of citrinin and its metabolite ( s ) while in rats rendered nephrotoxic by citrinin pretreatment , elimination is more dependent on hepatic excretion . | NA | {
"id": "C1373186",
"name": "route of elimination",
"pos": [
72,
92
]
} | {
"id": "C1373188",
"name": "hepatic excretion",
"pos": [
225,
242
]
} |
the cytotoxic properties of 2 anti-lymphocytic globulin ( alg ) preparations were investigated in vitro by measuring the release of 51cr from labelled human peripheral blood mononuclear cells , tonsil lymphocytes and chang cells , incubated with different concentrations of alg . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
157,
191
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
223,
228
]
} |
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