text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the synthetic sequence , cooh leads to coc1 leads to cochn2 leads to coch2x , was used with deoxycholic and cholic acids , which requires carefully controlled quench , work-up , and purification procedures , especially for the 3-sulfate esters ( made from deoxycholic acid derivatives only ) . | NA | {
"id": "C0008404",
"name": "cholic acids",
"pos": [
108,
120
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
256,
272
]
} |
the ecdysteroids from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity . | NA | {
"id": "C0058915",
"name": "ecdysteroids",
"pos": [
4,
16
]
} | {
"id": "C0013494",
"name": "molting hormone",
"pos": [
104,
119
]
} |
six naturally occurring c27 ecdysteroids were isolated and identified from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity . | NA | {
"id": "C0058915",
"name": "ecdysteroids",
"pos": [
28,
40
]
} | {
"id": "C0013494",
"name": "molting hormone",
"pos": [
157,
172
]
} |
evaluation of alterations in the level of the five major electrophoretic fractions of serum proteins ( albumin , alpha 1- , alpha 2- , beta- and gamma-globulin ) in 18 patients with prostatic cancer prior to and following cryoprostatectomy disclosed : ( i ) a progressive increase in the level of alpha 2- and beta-globu... | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
103,
110
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
432,
440
]
} |
formalin ( with a minimum content of 40 % of formaldehyde ) should be applied at a rate of at least 10 ml per 1 m3 of space and the agent should be diluted with water at 1 : 1 ratio prior to use . | NA | {
"id": "C0949307",
"name": "formalin",
"pos": [
0,
8
]
} | {
"id": "C0016564",
"name": "formaldehyde",
"pos": [
45,
57
]
} |
abnormalities in the structure of the sciatic nerve ( phagocytosis , myelin abnormalities , increase in nonspecific cholinesterase activity ) and tibial muscles ( angular atrophic fibers , group atrophy , fibre necrosis ) developed more frequently in animals on diets deficient in thiamine than in animals on diets with ... | NA | {
"id": "C0043047",
"name": "water",
"pos": [
401,
406
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
421,
435
]
} |
maintaining of the animals on a diet , deficient in vitamin c , within 4 weeks ( scorbutic animals ) was accompanied by 1.6-fold decrease in content of lipid peroxides in liver tissue as compared with control group . | NA | {
"id": "C0003969",
"name": "deficient",
"pos": [
39,
48
]
} | {
"id": "C0036474",
"name": "scorbutic",
"pos": [
81,
90
]
} |
basic proteins , occurring in blood plasma and used as standards ( globulin , interferon , rnaase , lysozyme ) , were markedly distinct in their electrophoretic properties from both histone fractions and the histone-like proteins isolated from blood plasma . | NA | {
"id": "C0017649",
"name": "globulin",
"pos": [
67,
75
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
221,
229
]
} |
however the isoenzyme apectrum of the enzyme was changed : content of m-subunits was decreased and the content of h-subunits was increased . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
12,
21
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
38,
44
]
} |
relative content of kallikrein in pleural exudates was lower and that of prekallikrein - higher as compared with transudates ; | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
20,
30
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
73,
86
]
} |
it was previously shown , in theory and in practice , that a blood component program utilizing 80 -- 85 % of all donations as red cell concentrates with a hematocrit of 70 % contributes substantially to the coverage of national albumin demands without increasing the need for that protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
228,
235
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
281,
288
]
} |
[ electromyographic study of the state of the neuromuscular apparatus in persons with prediabetes and diabetes mellitus ] . | NA | {
"id": "C0362046",
"name": "prediabetes",
"pos": [
86,
97
]
} | {
"id": "C0011849",
"name": "diabetes mellitus",
"pos": [
102,
119
]
} |
preliminary pharmacokinetic data on plasma concn of loxapine over 12 h from five psychiatric patients who received a total average dose of 80 mg of loxapine succinate per day orally for twelve weeks are presented . | NA | {
"id": "C0024056",
"name": "loxapine",
"pos": [
52,
60
]
} | {
"id": "C0024057",
"name": "loxapine succinate",
"pos": [
148,
166
]
} |
a specific class of dna sequences , the inverted repetitive sequences , forms a double-stranded structure within a single linear polynucleotide chain in denatured dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
163,
166
]
} |
the amount of l-dehydroascorbic acid ( das ) , which together with l-ascorbic acid ( as ) becomes vitamin c or total-vitamin c ( vc ) , proved to be of special interest . | NA | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
16,
36
]
} | {
"id": "C0003968",
"name": "vitamin c",
"pos": [
117,
126
]
} |
a high proportion of interfering substances especially when estimating vc was considered the cause for the normally measured amount of das . | NA | {
"id": "C0003968",
"name": "vc",
"pos": [
71,
73
]
} | {
"id": "C0011177",
"name": "das",
"pos": [
135,
138
]
} |
a simple and specific radioimmunoassay ( ria ) was developed for the determination of oxazepam and other 1,4-benzodiazepines in human blood serum and urine ( e.g. , diazepam , desmethyldiazepam , chlorazepate ) . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
165,
173
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
176,
193
]
} |
blood levels of diazepam and desmethyldiazepam determined by ria and glc after extraction are in satisfactory agreement . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
16,
24
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
29,
46
]
} |
by comparison of the radioactivity before and after extraction the following results were obtained : recovery from tissues 3h-digoxin 50 % 125j-digoxin 40 % from serum 3h-digoxin 60 % added to drug free tissue homogenates 3h-digoxin 85 % after i.p . application of 15 mg/kg of beta-methyldigoxin to bd9 ( berlin ) -rats ... | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
126,
133
]
} | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
277,
295
]
} |
beta-methyldigoxin and its metabolites digoxin and digoxinbisdigitoxide could be separated and distinguished from artifacts by fluorescence detection on hptlc-plates with a detection limit of 60 ng/spot . | NA | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
0,
18
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
51,
58
]
} |
the maximum plaque formation was observed under the following conditions : the monolayer of chick fibroblasts ( seeding density was not less than 375,000 cells per 1 sq . cm ) was grown in medium 199 with 5-10 % of fresh fetal or calf serum and inoculated with rickettsiae suspended in heart-brain infusion ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
98,
109
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
154,
159
]
} |
in those cases when influenza infection appeared in the presence of bacterial infection , the pathological process developed as a monoviral disease . | NA | {
"id": "C0030660",
"name": "pathological process",
"pos": [
94,
114
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
140,
147
]
} |
after the elimination of antibodies to light chains by adsorption these antisera were tested in immunoelectrophoresis and radial immunodiffusion in gel with sera containing g paraproteins of different subclasses . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
25,
35
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
72,
80
]
} |
[ transduction analysis of the genetic control of synthesis of the r-nucleus of the lipopolysaccharide of o-antigen ] . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
84,
102
]
} | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
106,
115
]
} |
[ comparative evaluation of diagnostic titers of incomplete o- and vi-antibodies belonging to different immunoglobulin classes in typhoid fever and chronic bacterial carrier state ] . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
70,
80
]
} | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
104,
126
]
} |
the studies have shown that the diverse character of combination of these symptoms and syndromes and the degree of their intensity depend on the depth of hypoxia , give evidence of the gravity of cerebral circulation disorders , and point to possible metabolic or structural changes in the newborn 's brain . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
87,
96
]
} | {
"id": "C0012634",
"name": "disorders",
"pos": [
217,
226
]
} |
equilibrium dialysis study of the interaction of bovine serum albumin and other proteins with alkylpyridinium bromide . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
62,
69
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
80,
88
]
} |
at high ph , in the co ( ii ) -gssg solution co ( ii ) is oxidized to co ( iii ) with the concomitant reduction of gssg to gsh . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
31,
35
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
123,
126
]
} |
in aqueous and non-aqueous solutions , copper ( ii ) interacts with the n-3 of cytidine but not with the carbonyl group oxygens of pyrimidine nucleosides . | NA | {
"id": "C0010715",
"name": "cytidine",
"pos": [
79,
87
]
} | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
131,
153
]
} |
unbound ( free ) and total kallikrein ( kallikrein + prekallikrein ) were analyzed with a chromogenic substrate ( s-2302 , kabi , sweden ) in which enzyme activity is determined spectrophotometrically by the development of a yellow colour . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
27,
37
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
53,
66
]
} |
maximal binding capacity was 1 . 10 ( -12 moles/mg protein ( = 2 ng lh-rh/pituitary gland ) , and the number of binding sites was calculated to be 6 . 10 ( 11 ) per mg membrane protein ( =1 . 10 ( 10 ) binding sites/pituitary gland ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
51,
58
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
168,
184
]
} |
the drug does not effect the basal and pentagastrin stimulated gastric secretion nor the serum gastrin concentration . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
39,
51
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
95,
102
]
} |
after 4 -- 6 weeks of a full dose cimetidine regimen , both basal and pentagastrin stimulated gastric acid secretion were reduced and peptone meal stimulated serum gastrin increased ; | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
70,
82
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
164,
171
]
} |
an autopsy case of rheumatoid arthritis with active polyarthritis , systemic necrotizing arteritis , pleuritis , pericarditis , rheumatoid nodules in a few organs and a healing gastric ulcer was reported . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
19,
39
]
} | {
"id": "C0035450",
"name": "rheumatoid nodules",
"pos": [
128,
146
]
} |
although it is hard to distinguish arteritis of pn type from the kussmaul-maier type periarteritis nodosa , arteritis of ra type with rheumatoid nodule-like lesion in the wall may be interpreted as an extremely developed form of vasculitis in rheumatoid arthritis . | NA | {
"id": "C0035450",
"name": "rheumatoid nodule",
"pos": [
134,
151
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
243,
263
]
} |
reproductive and teratological studies were undertaken with netilmicin ( sch 20569 ) , a new semisynthetic aminolgycoside antibiotic structurally related to sisomicin . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
60,
70
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
157,
166
]
} |
serum concentrations of diazepam and n-desmethyldiazepam were measured in six adult patients following administration of 10 mg diazepam in solution by the rectal , intravenous , and intramuscular routes . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
24,
32
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
39,
56
]
} |
the beta-inhibitory action of blood-borne noradrenaline was similar to the neural one , whereas that of adrenaline was more effective , causing decline of myogenic reactivity below control . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
42,
55
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
104,
114
]
} |
fulminant hepatic failure during remission from leukemia : three cases associated with massive liver cell necrosis and hepatitis b virus . | NA | {
"id": "C0162557",
"name": "fulminant hepatic failure",
"pos": [
0,
25
]
} | {
"id": "C0001364",
"name": "massive liver cell necrosis",
"pos": [
87,
114
]
} |
the alterations of lipid composition in sera of patients with liver diseases , particularly intrahepatic cholestasis and biliary obstruction , were studied by ultracentrifugation and polyacrylamide-gel disc-electrophoresis of lipoproteins and apoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
19,
24
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
226,
238
]
} |
the level of non-lipoprotein x cholesterol in intrahepatic cholestasis was significantly elevated , this being in part ascribed to the appearance of a new class of cholestatic lipoprotein , slow-migrating hdl . | NA | {
"id": "C0008372",
"name": "intrahepatic cholestasis",
"pos": [
46,
70
]
} | {
"id": "C0008370",
"name": "cholestatic",
"pos": [
164,
175
]
} |
such dna may then be inserted into vectors such as plasmids or bacteriophages which carry the dna into bacterial cells . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
5,
8
]
} | {
"id": "C0012924",
"name": "dna",
"pos": [
94,
97
]
} |
4 ) excessive protein intake , in addition to carbohydrate , may play a role in the pathogenesis of the hyperinsulinemia and insulin resistance found in obesity . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
104,
120
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
125,
143
]
} |
[ maternal stress response during pregnancy and labor with or without epidural/spinal relief of pain . adrenaline , noradrenaline , beta-endorphin , cortisol and acth ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
103,
113
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
116,
129
]
} |
significance as serum tumor marker , comparison to other glycolytic enzymes and isozyme patterns in normal and tumor tissue . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
68,
75
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
80,
87
]
} |
to investigate the mechanism of bacillus de calmette guerin ( bcg ) bladder instillation therapy , the killer cell activity induced in peripheral blood mononuclear cells ( pbmncs ) after bcg instillation was examined . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
110,
114
]
} | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
135,
151
]
} |
the effect of estramustine ( em ) , estradiol-17 beta ( e2 ) or 5 alpha-dihydrotestosterone ( dht ) on the growth of two human prostatic carcinoma cell lines , lncap and lncap-r was investigated . | NA | {
"id": "C0014921",
"name": "estramustine",
"pos": [
14,
26
]
} | {
"id": "C0014912",
"name": "estradiol-17 beta",
"pos": [
36,
53
]
} |
tick gut absorptive surface antigen glycoconjugates were identified by lectin blotting , using a series of probes with different carbohydrate specificities . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
36,
51
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
129,
141
]
} |
the in situ hybridizations resulted in 1/6 positive penile lichenoid lesions , 12/17 positive penile acuminate condylomas , 6/6 positive anal acuminate condylomas ( including two condylomas with cellular atypias ) , 2/3 positive giant condylomas , 1/4 positive anal bowenoid lesions , and 4/10 positive keratinized squam... | NA | {
"id": "C0276264",
"name": "giant condylomas",
"pos": [
229,
245
]
} | {
"id": "C0206706",
"name": "verrucous carcinomas",
"pos": [
360,
380
]
} |
the in situ hybridizations resulted in 1/6 positive penile lichenoid lesions , 12/17 positive penile acuminate condylomas , 6/6 positive anal acuminate condylomas ( including two condylomas with cellular atypias ) , 2/3 positive giant condylomas , 1/4 positive anal bowenoid lesions , and 4/10 positive keratinized squam... | NA | {
"id": "C0007097",
"name": "carcinomas",
"pos": [
329,
339
]
} | {
"id": "C0206706",
"name": "verrucous carcinomas",
"pos": [
360,
380
]
} |
the five positive carcinomas ( carcinoma in situ/invasive cancer ) contained hpv 6 and/or 11 in two cases ( including the verrucous carcinomas ) , and hpv 16 and/or 18 in three cases ( one carcinoma in situ , two invasive carcinomas ) . | NA | {
"id": "C0007097",
"name": "carcinomas",
"pos": [
18,
28
]
} | {
"id": "C0206706",
"name": "verrucous carcinomas",
"pos": [
122,
142
]
} |
the mutation altered the translational reading frame such that the codons of all but one of the last 15 amino acids of the protein were changed and the termination codon removed . | NA | {
"id": "C0009221",
"name": "codons",
"pos": [
67,
73
]
} | {
"id": "C0242611",
"name": "termination",
"pos": [
152,
163
]
} |
for example , a dna element ( box a , 91 bp ) is located at nucleotide positions 1981 to 2072 of the ecori civ dna fragment h which are complementary ( greater than 90 % ) to the nine regions of the pvuii dna fragment l ( l-boxes 1 to 9 ) . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
6,
7
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
205,
208
]
} |
most of the biv-related dna found in cells 96 hr after infection is present as linear unintegrated viral dna , although the presence of host flanking sequences in our proviral clones indicates that integration takes place . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
24,
27
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
99,
108
]
} |
a major vaccinia virus core protein , designated vp8 , has been purified from virions to homogeneity through deae-cellulose , cm-cellulose , and hydroxyapatite chromatography . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
109,
123
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
129,
138
]
} |
the cleavage site at which processing takes place lies between amino acids 32 ( gly ) and 33 ( ala ) from the n-terminal end of the precursor . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
63,
74
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
80,
83
]
} |
its antitumor properties were studied in 15 models of transplantable solid tumors and systemic neoplasms of mice and rats such as sarcoma 298 , sarcoma 37 , sarcoma-180 , lewis lung epidermoid carcinoma , carcinoma of the forestomach-5 , large bowel adenocarcinoma , harding-passey 's melanoma , cervical cancer-5 , mamm... | NA | {
"id": "C0243038",
"name": "lewis lung",
"pos": [
171,
181
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
475,
484
]
} |
the new , revised cdc case definition of aids ( 1 ) specifies precisely , which laboratory results and which diseases may indicate hiv-infection . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
41,
45
]
} | {
"id": "C0019693",
"name": "hiv-infection",
"pos": [
131,
144
]
} |
this review summarizes the principles and results of antiretroviral treatment of the hiv infection and chemotherapy of opportunistic infections in aids . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
85,
98
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
147,
151
]
} |
during the following 3 years , the patient developed on sun-exposed skin several premalignant hyperkeratoses , bowen 's carcinoma , basal cell carcinoma , as well as squamous cell carcinoma and carcinoma of the eccrine sweat glands , both showing the clinical picture of keratoacanthoma . | NA | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
120,
129
]
} | {
"id": "C0007117",
"name": "basal",
"pos": [
132,
137
]
} |
a nonphosphorylated host protein , which comigrated with ns2 on 1d gels , could be distinguished from viral proteins by isoelectric focusing on 2d gels . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
25,
32
]
} | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
102,
116
]
} |
these findings led us to re-examine previously reported results showing some homology between sfv , a leporipoxvirus and indiana , an orthopoxvirus ( berkowitz and pogo , virology 142 , 437-440 , 1985 ) using cloned fragments of sfv dna instead of the entire viral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
233,
236
]
} | {
"id": "C0012939",
"name": "viral",
"pos": [
259,
264
]
} |
identification of ribosomal proteins by two-dimensional gel electrophoresis indicated all changeable proteins ( at least five proteins ) to belong to 40s ribosomal subunits . | NA | {
"id": "C0035552",
"name": "ribosomal",
"pos": [
18,
27
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
126,
134
]
} |
-surgery was primarily applied to cope with surface wound and diseases in the 18th century , while pathological processes in the abdominal cavity and cranium became operable in the 19th century , owing to introduction of anaesthesia and antisepsis . | NA | {
"id": "C0012634",
"name": "diseases",
"pos": [
62,
70
]
} | {
"id": "C0030660",
"name": "pathological processes",
"pos": [
99,
121
]
} |
the glycolytic and oxidative capacity was evaluated by determining the activity of eight key enzymes in the intracellular oxidative metabolism , namely total creatine kinase ( ck ) , the isozymes ck-mb and mitochondrial ck , lactate dehydrogenase , citrate synthase , aspartate aminotransferase , and phosphofructokinase... | NA | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
158,
173
]
} | {
"id": "C0914594",
"name": "mitochondrial ck",
"pos": [
206,
222
]
} |
here we report the occurrence of adenomas ( prolactinomas ) in a new rat model at an early age . | NA | {
"id": "C0001430",
"name": "adenomas",
"pos": [
33,
41
]
} | {
"id": "C0033375",
"name": "prolactinomas",
"pos": [
44,
57
]
} |
it is concluded that niddm is not associated with an exaggerated release of proinsulin in response to glucose compared with healthy subjects , but the islets have maintained the ability to release proinsulin better than the ability to release insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
76,
86
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
243,
250
]
} |
the effects of treatment with gnrh , eb and ant were studied on the basis of 1 ) the height of the maximal lh response and 2 ) the half-maximally effective dose ( ed50 ) of buserelin . | NA | {
"id": "C0023610",
"name": "gnrh",
"pos": [
30,
34
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
173,
182
]
} |
a decrease in cholesterol , triglycerides , hdl-cholesterol , physical performance and an increase in ldl/hdl cholesterol quotient , lactate level , mental performance were accompanied by a lower frequency of mental complaints and higher frequency of physical complaints . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
14,
25
]
} | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
44,
59
]
} |
a decrease in cholesterol , triglycerides , hdl-cholesterol , physical performance and an increase in ldl/hdl cholesterol quotient , lactate level , mental performance were accompanied by a lower frequency of mental complaints and higher frequency of physical complaints . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
14,
25
]
} | {
"id": "C0023824",
"name": "in ldl",
"pos": [
99,
105
]
} |
since immunoreactivity for antigens of the hla-d-locus ( leu-hla-dr and leu 10 ) were present on the infiltrating mononuclear cells , it can be postulated that they represent active and immunocompetent cells . | NA | {
"id": "C0019754",
"name": "antigens",
"pos": [
27,
35
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
61,
67
]
} |
blood levels of glucose , insulin ( iri ) , calcium ( ca ) , phosphorus ( p ) , alkaline phosphatase ( ap ) , osteocalcin ( oc ) , parathyroid hormone ( pth ) , calcitonin ( ct ) , 25-hydroxyvitamin d3 ( 25ohd3 ) , 1,25-dihydroxyvitamin d3 ( 1,25 ( oh ) 2d3 ) and urinary excretion of ca ( ca/cr ) , p ( tmp/gfr ) , hydr... | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
181,
201
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
204,
210
]
} |
the amount of phospholipids , cholesterol and cholesterol esters found in the low molecular weight protein fraction was significantly higher than that present in the protein fraction with high molecular weight . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
30,
41
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
46,
64
]
} |
this lymphokine was biologically and biochemically distinct from interferon gamma , the interleukins , the colony stimulating factors and lymphotoxin . | NA | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
5,
15
]
} | {
"id": "C0024320",
"name": "lymphotoxin",
"pos": [
138,
149
]
} |
effect of trichothecene mycotoxins ( satratoxin h and t-2 toxin ) on the lymphoid organs of mice . | NA | {
"id": "C0040952",
"name": "trichothecene",
"pos": [
10,
23
]
} | {
"id": "C0039185",
"name": "t-2 toxin",
"pos": [
54,
63
]
} |
four sulphur-containing purine nucleoside analogues : 6mp , 6-thioinosine , 6-methylthioinosine and 6-ethylthioinosine , were examined for antiviral activity against some rna viruses . | NA | {
"id": "C0039904",
"name": "thioinosine",
"pos": [
62,
73
]
} | {
"id": "C0025828",
"name": "6-methylthioinosine",
"pos": [
76,
95
]
} |
production of antibodies against the majority of vv structural proteins , including nucleocapsid internal proteins was demonstrated in rabbits . | NA | {
"id": "C0042738",
"name": "vv structural proteins",
"pos": [
49,
71
]
} | {
"id": "C0524816",
"name": "nucleocapsid",
"pos": [
84,
96
]
} |
cholesterol is slightly increased in male hypertensives and diabetics of either sex , whereas low-density lipoprotein cholesterol is slightly raised in male hypertensives and female diabetics only . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
0,
11
]
} | {
"id": "C0023824",
"name": "low-density lipoprotein",
"pos": [
94,
117
]
} |
the possible mechanisms by which antihypertensive drugs affect cellular lipid metabolism ( e.g. , ldl receptor , lipid synthesis , lipoprotein lipase , lecithin cholesteryl acyltransferase , acylcholesteryl acyltransferase , and cholesteryl ester hydrolase ) are described . | NA | {
"id": "C0023194",
"name": "lecithin",
"pos": [
152,
160
]
} | {
"id": "C0001390",
"name": "acyltransferase",
"pos": [
207,
222
]
} |
when prl receptor was chromatographed on affinity columns containing prr-7a antibody or monoclonal antibody against hemocyanin , which served as a control , prl receptor was bound to the column containing prr-7a antibody , but not to the column containing control antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
88,
107
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
264,
272
]
} |
the mc migratory response was specifically inhibited in a dose-dependent and reversible manner by heparin and heparinlike glycosaminoglycans ( gags ) . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
98,
105
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
122,
140
]
} |
the cd1 ( t6 ) antigen , found on langerhans ( lh ) cells and cortical thymocytes , was detected on villous m phi s by two thirds of the mabs directed against different epitopes on this determinant . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
15,
22
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
169,
177
]
} |
information derived from ecog recordings has been shown to be helpful in the objective identification and monitoring of meniere 's disease and endolymphatic hydrops . | NA | {
"id": "C0025281",
"name": "meniere 's disease",
"pos": [
120,
138
]
} | {
"id": "C0206586",
"name": "endolymphatic hydrops",
"pos": [
143,
164
]
} |
uridine diphosphosugars ( udp-sugars : udp-n-acetylglucosamine , udp-glucose , and udp-glucuronic acid ) are essential coenzymes for the synthesis of glomerular basement membrane and mesangial matrix ( gbm-mm ) . | NA | {
"id": "C0041995",
"name": "udp-sugars",
"pos": [
26,
36
]
} | {
"id": "C0041993",
"name": "udp-n-acetylglucosamine",
"pos": [
39,
62
]
} |
uridine diphosphosugars ( udp-sugars : udp-n-acetylglucosamine , udp-glucose , and udp-glucuronic acid ) are essential coenzymes for the synthesis of glomerular basement membrane and mesangial matrix ( gbm-mm ) . | NA | {
"id": "C0041995",
"name": "udp-sugars",
"pos": [
26,
36
]
} | {
"id": "C0041988",
"name": "udp-glucose",
"pos": [
65,
76
]
} |
uridine diphosphosugars ( udp-sugars : udp-n-acetylglucosamine , udp-glucose , and udp-glucuronic acid ) are essential coenzymes for the synthesis of glomerular basement membrane and mesangial matrix ( gbm-mm ) . | NA | {
"id": "C0041995",
"name": "udp-sugars",
"pos": [
26,
36
]
} | {
"id": "C0041991",
"name": "udp-glucuronic acid",
"pos": [
83,
102
]
} |
in this study , the fast orthograde axonal transport of radiolabeled proteins was measured to determine the effects of endurance-running training on transport velocity and amounts of transported proteins in rat sciatic motoneurons . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
69,
77
]
} | {
"id": "C0007292",
"name": "transported proteins",
"pos": [
183,
203
]
} |
expression of the apical membrane disaccharidase trehalase correlates with the development of a proximal tubule-specific differentiated phenotype in the llc-pk1 cell line derived from renal epithelia . | NA | {
"id": "C0012610",
"name": "disaccharidase",
"pos": [
34,
48
]
} | {
"id": "C0040814",
"name": "trehalase",
"pos": [
49,
58
]
} |
hepatic venous plasma glucose , glucagon , insulin , epinephrine , and norepinephrine were measured during 120 min after injection of neostigmine ( 5 x 10 ( -8 ) mol ) into the third cerebral ventricle in rats subjected to bilateral adrenodemedullation ( admx ) to prevent epinephrine secretion ( observed insulin secret... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
53,
64
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
71,
85
]
} |
injection of neostigmine in intact rats resulted in increases in glucose , glucagon , epinephrine , and norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
86,
97
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
104,
118
]
} |
to evaluate the internalization of cholecystokinin , monoiodinated imidoester of cholecystokinin octapeptide [ 125i- ( ie ) -cck-8 ] was bound to dispersed pancreatic acinar cells , and surface-bound and internalized radioligand were differentiated by treating with an acidified glycine buffer . | NA | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
35,
50
]
} | {
"id": "C0037167",
"name": "cck-8",
"pos": [
125,
130
]
} |
to examine if these responses are mediated by different neurokinin receptors , we studied the mechanical response and the release of [ 3h ] acetylcholine from antral muscle strips in response to sp , substance p methylester ( spme ) , neurokinin a ( nka ) , neurokinin b ( nkb ) , and several non-mammalian tachykinins . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
200,
211
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
307,
318
]
} |
to examine if these responses are mediated by different neurokinin receptors , we studied the mechanical response and the release of [ 3h ] acetylcholine from antral muscle strips in response to sp , substance p methylester ( spme ) , neurokinin a ( nka ) , neurokinin b ( nkb ) , and several non-mammalian tachykinins . | NA | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
235,
247
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
307,
318
]
} |
to examine if these responses are mediated by different neurokinin receptors , we studied the mechanical response and the release of [ 3h ] acetylcholine from antral muscle strips in response to sp , substance p methylester ( spme ) , neurokinin a ( nka ) , neurokinin b ( nkb ) , and several non-mammalian tachykinins . | NA | {
"id": "C0027847",
"name": "neurokinin b",
"pos": [
258,
270
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
307,
318
]
} |
plasma cck concentrations were raised to levels comparable to postprandial values either by intravenous infusion of cck octapeptide ( cck-8 ) or by intraduodenal perfusion of soybean trypsin inhibitor ( sbti ) . | NA | {
"id": "C0008328",
"name": "cck",
"pos": [
7,
10
]
} | {
"id": "C0037167",
"name": "cck octapeptide",
"pos": [
116,
131
]
} |
jf was determined by labeling free cytosolic myo-inositol by incubation of unstimulated muscle with myo- [ 3h ] inositol and then measuring rates of incorporation of this isotope into inositol phospholipids and inositol phosphates when the muscle was activated by nor . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
49,
57
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
211,
230
]
} |
however , only higher concentrations of adenosine , neca , and l-pia inhibited 100 mm kcl-induced calcium influx . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
40,
49
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
52,
56
]
} |
previous treatment with 8-phenyltheophylline blocked the inhibitory actions of adenosine , neca , and l-pia on calcium influx . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
79,
88
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
91,
95
]
} |
the inhibition of calcium influx by adenosine , neca , and l-pia correlated well with their relaxing ability in the presence of prostaglandin f2 alpha . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
36,
45
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
48,
52
]
} |
this inhibitory action of the antiserum was similar to that induced by the angiotensin ii antagonist , saralasin . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
75,
89
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
103,
112
]
} |
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