text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
gaba ( 10 ( -8 ) -10 ( -5 ) m ) and muscimol ( 10 ( -8 ) -10 ( -5 ) m ) , but not baclofen ( 10 ( -5 ) m ) , reduced the ca2+-dependent , tetrodotoxin-resistant release of [ 3h ] gaba evoked by high k+ from the urinary bladder strips preloaded with [ 3h ] gaba . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
82,
90
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
256,
260
]
} |
treatment with proteolytic enzymes such as pronase and trypsin inactivated the antigen activity , indicating that the antigen epitope could be a peptide portion of the glycoprotein . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
79,
86
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
126,
133
]
} |
seven different malignant cell types were identified : squamous cell , adenocarcinoma , large cell , small cell , carcinoid , embryonal cell , and malignant fibrous histiocytoma . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
71,
85
]
} | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
114,
123
]
} |
high performance liquid chromatography indicated that nka-li consisted of several cross-reacting substances , presumably other peptides of the tachykinin family . | NA | {
"id": "C0038581",
"name": "nka-li",
"pos": [
54,
60
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
143,
153
]
} |
among the isolated mammalian tachykinins , nka was the most potent one to contract tracheal smooth muscle of guinea pigs in vitro , followed by neurokinin b and by sp . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
29,
40
]
} | {
"id": "C0027847",
"name": "neurokinin b",
"pos": [
144,
156
]
} |
the pulmonary vascular responses to histamine , epinephrine , and norepinephrine demonstrate tachyphylaxis following repetitive exposure in the isolated blood-perfused cat lung . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
48,
59
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
66,
80
]
} |
all the experiments with norepinephrine ( n = 6 ) , epinephrine ( n = 10 ) , and histamine ( n = 25 ) demonstrated a progressive loss of vasopressor activity as shown by reductions in the maximum response and slope between dr i to iv . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
25,
39
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
52,
63
]
} |
the procoagulant activity was initiated by factor vii-tissue factor complexes as judged by differential activity in various plasmas genetically deficient in single clotting factors , by neutralization of the procoagulant activity with antibodies to either factor vii or tissue factor , and by a factor x activation assay... | NA | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
164,
180
]
} | {
"id": "C0040048",
"name": "tissue factor",
"pos": [
270,
283
]
} |
when lavage and diluted plasma were adjusted to yield equivalent amidolytic activities , the average ratio of the factor vii-clotting activity of the alveolar fluid relative to plasma factor vii was 19 +/- 7 , suggesting the presence of factor viia in lavage . | NA | {
"id": "C0015502",
"name": "factor vii",
"pos": [
114,
124
]
} | {
"id": "C0015505",
"name": "factor viia",
"pos": [
237,
248
]
} |
in contrast to previous reports with serum or activated plasma , immunoblots of concentrated lavage revealed only single-chain factor vii , and 125i-factor vii added to the fluid was not converted to 125i-factor viia , suggesting a unique control mechanism in the lung compartment which differs from plasma . | NA | {
"id": "C0015502",
"name": "factor vii",
"pos": [
127,
137
]
} | {
"id": "C0015505",
"name": "factor viia",
"pos": [
205,
216
]
} |
the protein was isolated on deae-cellulose and cm-cellulose columns by a cross-reaction with the monoclonal antibody against pig low mw protein ( 15 kda ) used as a marker . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
28,
42
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
50,
59
]
} |
the stimuli produced neurogenic inflammation in both groups of rats , but the magnitude of this inflammation was much greater in the infected rats . | NA | {
"id": "C0600467",
"name": "neurogenic",
"pos": [
21,
31
]
} | {
"id": "C0021368",
"name": "inflammation",
"pos": [
96,
108
]
} |
three and 6 h after the development of eia , pmn isolated from 10 asthmatic subjects and stimulated in vitro by 2 x 10 ( 8 ) and 4 x 10 ( 8 ) zymosan particles per 2 x 10 ( 6 ) pmn demonstrated a 12- and 4-fold enhancement , respectively , in the production of immunoreactive ltb4 as compared with pmn isolated before ex... | NA | {
"id": "C0004099",
"name": "eia",
"pos": [
39,
42
]
} | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
66,
75
]
} |
felodipine is a new calcium antagonist of the dihydropyridine group with a high selectivity for arteriolar smooth muscle ; | NA | {
"id": "C0015772",
"name": "felodipine",
"pos": [
0,
10
]
} | {
"id": "C2945601",
"name": "calcium antagonist",
"pos": [
20,
38
]
} |
in these studies , we demonstrate that supernatants of silica-stimulated human alveolar macrophages cause significantly ( p less than 0.05 ) greater amounts of fibroblast proliferation than do supernatants of macrophages stimulated with optimal amounts of endotoxin ( lps ) . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
256,
265
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
268,
271
]
} |
although ice machines are infrequently implicated in nosocomial outbreaks , they represent a potential source for pathogens that survive or replicate in water . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
9,
12
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
153,
158
]
} |
alveolar macrophages attached to a plastic substrate produced at least five identified aa metabolites including prostaglandin ( pg ) f2 alpha , hydroxyheptadecatrienoic acid ( hht ) , 5-hydroxyeicosatetraenoic acid ( hete ) , 12-hete , and 15-hete . | NA | {
"id": "C0044800",
"name": "12-hete",
"pos": [
226,
233
]
} | {
"id": "C0020349",
"name": "hete",
"pos": [
243,
247
]
} |
in contrast , adherent intravascular macrophages produced eight identified metabolites including thromboxane ( tx ) b2 , pgf2 alpha , pgd2 , pge2 , hht , 5-hete , 12-hete , and 15-hete . | NA | {
"id": "C0044800",
"name": "12-hete",
"pos": [
163,
170
]
} | {
"id": "C0020349",
"name": "hete",
"pos": [
180,
184
]
} |
both macrophage populations treated with calcium ionophore ( a23187 ) exhibited increased production of pgs , txb2 , leukotriene ( lt ) b4 , 5-hete , 12-hete , and 15-hete , but the most striking increase occurred in metabolism through the lipoxygenase pathway . | NA | {
"id": "C0044800",
"name": "12-hete",
"pos": [
150,
157
]
} | {
"id": "C0020349",
"name": "hete",
"pos": [
167,
171
]
} |
studies of leukotriene formation demonstrated that both macrophage types produce ltc4 and ltb4 from the leukotriene precursor lta4 . | NA | {
"id": "C0023545",
"name": "leukotriene",
"pos": [
11,
22
]
} | {
"id": "C0125631",
"name": "lta4",
"pos": [
126,
130
]
} |
a likely mechanism for this effect is an ozone-induced inhibition in the ability of pulmonary alveolar macrophages ( pam ) to produce superoxide anion radical ( o2- ) demonstrated in the present study . | NA | {
"id": "C0030106",
"name": "ozone",
"pos": [
41,
46
]
} | {
"id": "C0030054",
"name": "o2",
"pos": [
161,
163
]
} |
in contrast , the rat , which is highly resistant to the potentiation of bacterial infections by ozone , was less sensitive to inhibition of pam o2- production , as measured by cytochrome c reduction ( mouse ic50 , 0.41 ppm ; rat ic50 , 3.0 ppm ozone for 3 h ) . | NA | {
"id": "C0030106",
"name": "ozone",
"pos": [
97,
102
]
} | {
"id": "C0030054",
"name": "o2",
"pos": [
145,
147
]
} |
a decrease in rat pam membrane cytochrome b558 levels was observed after ozone exposure of 3 ppm for 3 h , preliminarily suggesting that the mechanism by which ozone interferes with pam o2- production may be through interaction with this heme-containing electron carrier . | NA | {
"id": "C0030106",
"name": "ozone",
"pos": [
73,
78
]
} | {
"id": "C0030054",
"name": "o2",
"pos": [
186,
188
]
} |
mast cells isolated by either enzymatic or mechanical means from human lung parenchyma were both similarly responsive to the modulatory effects of adenosine and analogues , and the potency series of neca greater than r-pia also applied . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
147,
156
]
} | {
"id": "C0031484",
"name": "r-pia",
"pos": [
217,
222
]
} |
moreover , histamine release induced by the calcium ionophore a23187 was augmented by neca , r-pia , and adenosine and in that potency order . | NA | {
"id": "C0031484",
"name": "r-pia",
"pos": [
93,
98
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
105,
114
]
} |
these findings provide direct and quantitative evidence that the bronchi are the main site of airway narrowing in exercise-induced asthma , and draw attention to the phenomenon of tracheal dilatation that occurs concomitant with bronchoconstriction in asthmatic patients . | NA | {
"id": "C0004099",
"name": "exercise-induced asthma",
"pos": [
114,
137
]
} | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
252,
261
]
} |
the purposes were ( 1 ) to evaluate the prevalence of interstitial lung disease ( ild ) and work-related wheezing , ( 2 ) to assess correlations between cobalt exposure and pulmonary disease , ( 3 ) to compare lung disease in grinders of hard carbide versus nongrinders , and ( 4 ) to evaluate the effects of new and pre... | NA | {
"id": "C0206062",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0024115",
"name": "lung disease",
"pos": [
210,
222
]
} |
forty-eight hours later , the animals were challenged intravenously with mouse serum albumin conjugated to dnp ( 1 to 25 micrograms ) and received 125i-labeled bovine albumin at the same time to permit assessment of leakage of vascular proteins into the lungs . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
85,
92
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
236,
244
]
} |
we measured the amount of 125i-labeled albumin in bronchoalveolar lavage ( bal ) fluid and whole lung tissue and the wet/dry lung weight ratio to assess pulmonary transvascular protein flux and edema . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
39,
46
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
177,
184
]
} |
to assess the possible contribution of circulating catecholamines to this decrease , plasma epinephrine and norepinephrine levels were measured in six experiments , before and 30 s , 1 , 3 , and 5 min after the stimulation . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
92,
103
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
108,
122
]
} |
in a second set of experiments , we examined whether allergic subjects with demonstrable bronchomotor responsiveness to so2 also had nasal responsiveness to the gas . | NA | {
"id": "C0038777",
"name": "so2",
"pos": [
120,
123
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
161,
164
]
} |
for this purpose , a phenotypic and functional characterization of lymphocytes recovered from the bronchoalveolar lavage ( bal ) fluid of 24 patients with clinical symptoms and signs of hiv infections was performed ( six patients with constitutional disease , five patients with neurologic manifestations , and 13 patien... | NA | {
"id": "C0019693",
"name": "hiv infections",
"pos": [
186,
200
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
339,
343
]
} |
type iii groups together 10 autoimmune diseases ( autoimmune thyroid disease , myasthenia and/or thymoma , sjogren 's syndrome , pernicious anaemia , idiopathic thrombocytopaenic purpura , addison 's disease , insulin-dependent diabetes , vitiligo , autoimmune haemolytic anaemia , systemic lupus erythematosus ) for whi... | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
28,
47
]
} | {
"id": "C0398650",
"name": "idiopathic thrombocytopaenic purpura",
"pos": [
150,
186
]
} |
type iii groups together 10 autoimmune diseases ( autoimmune thyroid disease , myasthenia and/or thymoma , sjogren 's syndrome , pernicious anaemia , idiopathic thrombocytopaenic purpura , addison 's disease , insulin-dependent diabetes , vitiligo , autoimmune haemolytic anaemia , systemic lupus erythematosus ) for whi... | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
28,
47
]
} | {
"id": "C0011854",
"name": "insulin-dependent diabetes",
"pos": [
210,
236
]
} |
type iii groups together 10 autoimmune diseases ( autoimmune thyroid disease , myasthenia and/or thymoma , sjogren 's syndrome , pernicious anaemia , idiopathic thrombocytopaenic purpura , addison 's disease , insulin-dependent diabetes , vitiligo , autoimmune haemolytic anaemia , systemic lupus erythematosus ) for whi... | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
28,
47
]
} | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
282,
310
]
} |
thrombocytopenia was due to an immunological mechanism and preceded thrombotic phenomena , so emphasizing the need for platelet counts in all patients considered for heparin or synthetic heparinoid therapy . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
166,
173
]
} | {
"id": "C0019142",
"name": "heparinoid",
"pos": [
187,
197
]
} |
in studies of focal epilepsy it is frequently assumed that the interictal spike is the elementary form of epileptic activity and that seizure , or ictal , episodes evolve by temporal summation and spatial expansion of interictal paroxysms . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
106,
115
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
134,
141
]
} |
concentrations of the neuropeptides somatostatin and neuropeptide y , which colocalize in neurons containing nadph-d , were unaffected in the areas of ischemic damage . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
22,
35
]
} | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
53,
67
]
} |
using an in vitro system we measured the corneal epithelial cytotoxicity and the antiviral activity of the antiviral agents idoxuridine ( idu ) , trifluridine ( tft ) , ethyldeoxyuridine ( edu ) , and ( e ) -5- ( 2-bromovinyl ) -2'-deoxyuridine ( bvdu ) . | NA | {
"id": "C0020811",
"name": "idoxuridine",
"pos": [
124,
135
]
} | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
232,
244
]
} |
a total of 298 children with a history of adverse reactions in connection with oral penicillin treatment were investigated with a radioallergosorbent test for penicillin metabolites , the skin prick test , and oral challenge with penicillin v . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
84,
94
]
} | {
"id": "C0030840",
"name": "penicillin",
"pos": [
230,
240
]
} |
the successful application of this technique in children suggests that electromagnetic stimulation of the motor cortex has the potential to allow detection of abnormality in motor pathways in newborn babies and young children . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
48,
56
]
} | {
"id": "C0728836",
"name": "young children",
"pos": [
211,
225
]
} |
examination of the reaction products showed that free anionic sulphite is formed with no evidence for `` '' bound-sulphite ( s ) '' '' as intermediate . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
54,
61
]
} | {
"id": "C0038750",
"name": "-sulphit",
"pos": [
113,
121
]
} |
the calculation of the apparent precaecal and faecal crude protein ( cp ) digestibility and of the absorption values of the essential aa lysine , methionine , cystine , isoleucine , threonine and tryptophan as well as of glutamic acid was carried out according to the difference method . | NA | {
"id": "C0002525",
"name": "essential aa",
"pos": [
124,
136
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
146,
156
]
} |
the calculation of the apparent precaecal and faecal crude protein ( cp ) digestibility and of the absorption values of the essential aa lysine , methionine , cystine , isoleucine , threonine and tryptophan as well as of glutamic acid was carried out according to the difference method . | NA | {
"id": "C0002525",
"name": "essential aa",
"pos": [
124,
136
]
} | {
"id": "C0040005",
"name": "threonine",
"pos": [
182,
191
]
} |
longitudinal studies of children with febrile convulsions and evoked spikes in the eeg are necessary to verify a possible high risk of developing epilepsy not predicted on clinical data . | NA | {
"id": "C0009952",
"name": "febrile convulsions",
"pos": [
38,
57
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
146,
154
]
} |
the effect of administration of prostaglandins on myoblast proliferation was also examined and pge was found to suppress proliferation . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
32,
46
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
95,
98
]
} |
cholesterol , triglycerides , very low density lipoprotein cholesterol ( vldl-c ) , low density lipoprotein cholesterol ( ldl-c ) , and high density lipoprotein cholesterol ( hdl-c ) were measured in blood samples from 125 crewmembers on the first 24 space shuttle flights . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
0,
11
]
} | {
"id": "C0023826",
"name": "very low density lipoprotein cholesterol",
"pos": [
30,
70
]
} |
cholesterol , triglycerides , very low density lipoprotein cholesterol ( vldl-c ) , low density lipoprotein cholesterol ( ldl-c ) , and high density lipoprotein cholesterol ( hdl-c ) were measured in blood samples from 125 crewmembers on the first 24 space shuttle flights . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
0,
11
]
} | {
"id": "C0023824",
"name": "low density lipoprotein cholesterol",
"pos": [
84,
119
]
} |
cholesterol , triglycerides , very low density lipoprotein cholesterol ( vldl-c ) , low density lipoprotein cholesterol ( ldl-c ) , and high density lipoprotein cholesterol ( hdl-c ) were measured in blood samples from 125 crewmembers on the first 24 space shuttle flights . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
0,
11
]
} | {
"id": "C0023822",
"name": "high density lipoprotein",
"pos": [
136,
160
]
} |
another group of rats given identical exposure to the fluids had their brains prepared for measuring opiate receptor binding using the delta-receptor ligand [ 3h ] d-ala-d-leu-enkephalin ( [ 3h ] dadle ) and the mu-receptor selective ligand [ 3h ] tyr-d-ala-gly-mephe-gly-ol ( [ 3h ] dago ) . | NA | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
172,
186
]
} | {
"id": "C0079286",
"name": "dadle",
"pos": [
196,
201
]
} |
it is argued that wheat endosperm lacks significant plastidic fructose-1,6-bisphosphatase and that carbon for starch synthesis does not enter the amyloplast as a c-3 compound but probably as hexose phosphate . | NA | {
"id": "C0016745",
"name": "fructose",
"pos": [
62,
70
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
191,
197
]
} |
( b ) studies on the relative potency of various cofactors in activating the enzyme revealed that ps , phorbol myristate acetate and 1-stearoyl-2-arachidonylglycerol were the most potent of the phospholipids , phorbol esters and diacylglycerols respectively . | NA | {
"id": "C0039654",
"name": "phorbol myristate acetate",
"pos": [
103,
128
]
} | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
210,
224
]
} |
it can use nadh ( vmax./km 3.36 s-1 ) and nadph ( vmax./km 1.07 s-1 ) when 6-methyldihydro- ( 6h ) -pterin is the second substrate , as well as quinonoid dihydro- ( 6h ) -biopterin ( vmax./km 0.69 s-1 ) , dihydro- ( 6h ) -neopterin ( vmax./km 0.58 s-1 ) , dihydro- ( 6h ) -monapterin 0.66 s-1 ) , 6-methyldihydro- ( 6h )... | NA | {
"id": "C0005562",
"name": "biopterin",
"pos": [
171,
180
]
} | {
"id": "C0068527",
"name": "neopterin",
"pos": [
222,
231
]
} |
the variation of ki ( keo , i ) with ph for two ethanol-competitive inhibitors , pyrazole and 2,2,2-trifluoroethanol , was also studied . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
48,
55
]
} | {
"id": "C0040983",
"name": "trifluoroethanol",
"pos": [
100,
116
]
} |
when analysis of inositol phosphates was performed by h.p.l.c. , plasma from uninephrectomized rats stimulated a rapid increase in ins ( 1,4,5 ) p3 radioactivity , whereas the increase in inositol 1,3,4,5-tetrakisphosphate and ins ( 1,3,4 ) p3 radioactivity was slower . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
17,
36
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
188,
196
]
} |
the abilities of d-myo-inositol phosphates ( insps ) to promote ca2+ release and to compete for d-myo- [ 3h ] -inositol 1,4,5-trisphosphate [ ( 3h ] ins ( 1,4,5 ) p3 ) binding were examined with microsomal preparations from rat cerebellum . | NA | {
"id": "C0021554",
"name": "myo-inositol phosphates",
"pos": [
19,
42
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
111,
119
]
} |
that this effect was observed only after ins ( 1,4,5 ) p3 may reflect differences in either the metabolic rates of the various insps or an effect of the ins ( 1,4,5 ) p3 metabolite ins ( 1,3,4,5 ) p4 to stimulate refilling of the ins ( 1,4,5 ) p3-sensitive store . | NA | {
"id": "C0021554",
"name": "insps",
"pos": [
127,
132
]
} | {
"id": "C0021549",
"name": "p3",
"pos": [
244,
246
]
} |
based on this result and taking into account the content of free fatty acids and diacylglycerols in hemolymph , the incorporation of free fatty acids , expressed in moles of fatty acids , seems to be 3.4 times higher than that of diacylglycerols . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
60,
76
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
174,
185
]
} |
elevated hgf/interleukin-6 concentrations were also positively correlated with increased serum concentrations of the hepatic acute phase reactant protein , amyloid p . | NA | {
"id": "C0001347",
"name": "acute",
"pos": [
125,
130
]
} | {
"id": "C0002721",
"name": "amyloid p",
"pos": [
156,
165
]
} |
labeled phosphatidylinositol ( pi ) , polyphosphoinositides ( pip and pip2 ) and a novel phosphatidylinositol-glycan ( pi-glycan ) were measured after separation by tlc . | NA | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
8,
28
]
} | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
38,
59
]
} |
labeled phosphatidylinositol ( pi ) , polyphosphoinositides ( pip and pip2 ) and a novel phosphatidylinositol-glycan ( pi-glycan ) were measured after separation by tlc . | NA | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
38,
59
]
} | {
"id": "C0070798",
"name": "pip2",
"pos": [
70,
74
]
} |
fly ash and fly ash residue increased the formation of conjugated dienes and the levels of oxidized glutathione ( gssg ) and reduced the levels of reduced glutathione ( gsh ) in lung and liver whereas fly ash extract administration had no effect on the formation of conjugated dienes and glutathione levels in lung and l... | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
114,
118
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
288,
299
]
} |
the effect on energetic metabolism of rat liver mitochondria ( rlm ) of styrene and other aliphatic benzene derivatives , i.e . toluene , ethylbenzene , alpha-methylstyrene and butylbenzene , is studied . | NA | {
"id": "C0005037",
"name": "benzene derivatives",
"pos": [
100,
119
]
} | {
"id": "C0040383",
"name": "toluene",
"pos": [
128,
135
]
} |
we conclude that azole antifungal agents of differing structure show different patterns of selective interaction with cytochromes p-450 , a phenomenon primarily dependent on the 1-substituent on the azole ring , but also modulated to a lesser extent by the type of azole ring ( imidazole or triazole ) . | NA | {
"id": "C0004504",
"name": "azole",
"pos": [
17,
22
]
} | {
"id": "C0040880",
"name": "triazole",
"pos": [
291,
299
]
} |
carbachol ( 10 microm ) rapidly enhanced the choline efflux by a muscarinic mechanism , that was independent of mepacrine , an inhibitor of phospholipase a2 , as well as of extracellular ca2+ ; | NA | {
"id": "C0006945",
"name": "carbachol",
"pos": [
0,
9
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
45,
52
]
} |
similar to the carbachol-evoked choline efflux , the increase in tissue content of phosphatidic acid by carbachol was unaffected by infusion of a ca2+-free , egta-containing solution . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
32,
39
]
} | {
"id": "C0006945",
"name": "carbachol",
"pos": [
104,
113
]
} |
sodium oleate ( 20 microm ) , an activator of phospholipase d , imitated the effects of carbachol on choline and phosphatidic acid , whereas naf ( 5 mm ) , which has been reported to inhibit phospholipase d , blocked carbachol-evoked efflux of choline . | NA | {
"id": "C0006945",
"name": "carbachol",
"pos": [
88,
97
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
244,
251
]
} |
to this end , various doses of the gaba-t inhibitors ethanolamine-o-sulfate ( eos ) and gamma-vinyl gaba ( gvg ) were injected intracisternally and effects on whole brain gaba , food and water intake , open field activity , catalepsy indices , pain sensitivity , and core temperature were assessed 24 h later . | NA | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
88,
104
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
171,
175
]
} |
the ethanol dehydrogenase ( km ( ethanol ) = 14 microm ) resembles the dye-dependent quinoprotein methanol dehydrogenases of methylotrophic bacteria , but has a low affinity for methanol ( km ( methanol ) = 94mm ) . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
4,
11
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
194,
202
]
} |
this is illustrated by the reduction of ( e ) -2-methylcinnamyl aldehyde to ( r ) -2-methyl-3-phenylpropanal or ( r ) -2-methyl-3-phenylpropanol under different conditions and measuring the racemisation of the aldehyde as well as the hydrogen-deuterium exchange of 3-phenylpropanal . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
234,
242
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
243,
252
]
} |
the major toxin at this position contains glutamine , while the minor toxin contains glutamic acid . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
42,
51
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
85,
98
]
} |
medullasin , a serine protease in bone marrow cells , resembles elastase , but is essentially devoid of elastinolytic activity . | NA | {
"id": "C0064833",
"name": "serine protease",
"pos": [
15,
30
]
} | {
"id": "C0030306",
"name": "elastase",
"pos": [
64,
72
]
} |
the protease revealed elastinolytic activity when small amounts of other proteases such as trypsin , papain , chymotrypsin , or collagenase coexisted in the incubation mixture . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
4,
12
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
73,
82
]
} |
no inhibition was found with the human proteinases thrombin , coagulation factor xa , urokinase , tissue plasminogen activator , cathepsin g , leukocyte elastase and pancreatic elastase . | NA | {
"id": "C0064833",
"name": "leukocyte elastase",
"pos": [
143,
161
]
} | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
166,
185
]
} |
the changing pattern of these proteinases and their potential inhibitors ( chymase/a 1-proteinase inhibitor and trypsin-like proteinase/contrapsin ) may be a factor contributing to muscle wasting as observed in diabetes and fasting . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
30,
41
]
} | {
"id": "C0030946",
"name": "proteinase",
"pos": [
125,
135
]
} |
the alignment indicates that all zymogens have a lysine residue at position p36 ( porcine pepsinogen numbering ) . | NA | {
"id": "C0014436",
"name": "zymogens",
"pos": [
33,
41
]
} | {
"id": "C0030913",
"name": "pepsinogen",
"pos": [
90,
100
]
} |
on isoelectrofocusing , the isoenzyme pattern of the tumour enzyme was shifted somewhat towards more basic pi values by comparison with rat liver cathepsin d . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
28,
37
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
60,
66
]
} |
phosphorus is the sixth most abundant element in the body after oxygen , hydrogen , carbon , nitrogen , and calcium . | NA | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
0,
10
]
} | {
"id": "C0013879",
"name": "element",
"pos": [
38,
45
]
} |
phosphorus is the sixth most abundant element in the body after oxygen , hydrogen , carbon , nitrogen , and calcium . | NA | {
"id": "C0013879",
"name": "element",
"pos": [
38,
45
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
73,
81
]
} |
phosphorus is the sixth most abundant element in the body after oxygen , hydrogen , carbon , nitrogen , and calcium . | NA | {
"id": "C0013879",
"name": "element",
"pos": [
38,
45
]
} | {
"id": "C0007009",
"name": "carbon",
"pos": [
84,
90
]
} |
phosphorus is the sixth most abundant element in the body after oxygen , hydrogen , carbon , nitrogen , and calcium . | NA | {
"id": "C0013879",
"name": "element",
"pos": [
38,
45
]
} | {
"id": "C0028158",
"name": "nitrogen",
"pos": [
93,
101
]
} |
insulin resistance , leading to diabetes , hyperinsulinaemia , and secondary lipoprotein disturbances , is a possible mechanism for the high rates of coronary heart disease in south asians in britain and overseas . | NA | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
0,
18
]
} | {
"id": "C0020459",
"name": "hyperinsulinaemia",
"pos": [
43,
60
]
} |
data from the initial examination in a large prospective study of cardiovascular disease in middle aged men ( the british regional heart study ) were used to separate 7710 men into three groups on the basis of a resting electrocardiogram , a standardised chest pain questionnaire , and recall of a doctor 's diagnosis of... | NA | {
"id": "C0008031",
"name": "chest pain",
"pos": [
255,
265
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
321,
327
]
} |
the estimated pa2s for the alpha 1-adrenoceptor antagonist prazosin against the alpha-adrenoceptor agonists phenylephrine , alpha-methylnoradrenaline and noradrenaline were not significantly different . | NA | {
"id": "C0025805",
"name": "alpha-methylnoradrenaline",
"pos": [
124,
149
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
154,
167
]
} |
although the competitive inhibition between some sulphonamides and tolbutamide is consistent with metabolism by the same isozyme of cytochrome p-450 it does not prove it and further studies with purified enzymes will be necessary to confirm this . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
121,
128
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
204,
211
]
} |
the concentration of il2r was measured in the sera of patients with atopic dermatitis ( n = 58 ) or psoriasis , without psoriatic arthritis , ( n = 26 ) , who had moderate to severe disease activity , and in non-atopic healthy controls ( n = 37 ) by an elisa technique . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
100,
109
]
} | {
"id": "C0003872",
"name": "psoriatic",
"pos": [
120,
129
]
} |
ichthyosis was noted at birth or immediately afterwards in 59 % of the patients with xli while it appeared in infancy in 68 % of those with iv . | NA | {
"id": "C0020757",
"name": "ichthyosis",
"pos": [
0,
10
]
} | {
"id": "C0079584",
"name": "iv",
"pos": [
140,
142
]
} |
x-linked ichthyosis was characterized by the presence of lesions in the pre-auricular area , which were found in 93 % of the cases with xli , while only 17 % of the iv patients had ichthyotic lesions at this site . | NA | {
"id": "C0079584",
"name": "iv",
"pos": [
165,
167
]
} | {
"id": "C0020757",
"name": "ichthyotic",
"pos": [
181,
191
]
} |
isoform ii was eluted with a 0.1 m phosphate buffer ph 8.0 containing 0.5 mm nad , was the most active with medium- and long-chain aliphatic aldehydes ( c6-c11 ) and had km values for mda and acetaldehyde equal to 37 microm and 52 microm , respectively . | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
141,
150
]
} | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
192,
204
]
} |
group c was given a single dose of 1.5 mg of fluoride ( as sodium fluoride ) and group d was given 2 daily doses of fluoride ( as sodium fluoride ) totaling 1.5 mg . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
45,
53
]
} | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
130,
145
]
} |
relationship of molecular radical anion abundance and calculated lowest unoccupied molecular orbital energies for polychlorinated dibenzofurans and dibenzodioxins in electron capture negative ion mass spectrometry : evidence for negative metastable ions . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
34,
39
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
249,
253
]
} |
these events are regulated by the interaction of leucocytes with stromal cells and locally produced cytokines and growth factors , and may be modulated by the fatty acid composition of cellular membrane phospholipids and extracellular fluid unesterified fatty acids . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
159,
169
]
} | {
"id": "C0015688",
"name": "unesterified fatty acids",
"pos": [
241,
265
]
} |
histological examination of skin and mesenteric biopsies confirmed the diagnosis of weber-christian disease ( systemic panniculitis ) suggested by clinical features . | NA | {
"id": "C0030328",
"name": "weber-christian disease",
"pos": [
84,
107
]
} | {
"id": "C0030326",
"name": "panniculitis",
"pos": [
119,
131
]
} |
toxin a is an enterotoxin believed to be responsible for the diarrhea and mucosal tissue damage which occur during the disease . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
0,
5
]
} | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
14,
25
]
} |
however , when combined with safe and efficacious penicillins or cephalosporins , these inhibitors can serve to protect the familiar beta-lactam antibiotics from hydrolysis by penicillinases or broad-spectrum beta-lactamases . | NA | {
"id": "C0030841",
"name": "penicillinases",
"pos": [
176,
190
]
} | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
209,
224
]
} |
cytogenetic studies are reported on 17 t-cell malignant lymphomas ( ml ) including six cutaneous t-cell malignant lymphomas ( ctcl ) . | NA | {
"id": "C0079772",
"name": "t-cell malignant lymphomas",
"pos": [
39,
65
]
} | {
"id": "C0079773",
"name": "ctcl",
"pos": [
126,
130
]
} |
the survival of chinese hamster fibroblasts was reduced when the cells were exposed to 0.1-1.0 mg/l 4'-epidoxorubicin ( epirubicin ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
32,
43
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
65,
70
]
} |
the growth kinetics of chick embryo fibroblast clones can be accounted for if it is assumed that : ( 1 ) there is a transient , and rather substantial , decline in mean tc ( from 34 to 12 hr ) immediately following the commitment of a 'stem ' cell daughter to a limited replicative lifespan ; | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
36,
46
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
215,
218
]
} |
the functional female product shows sequence similarities with ribonucleoproteins , suggesting that it is an rna binding protein . | NA | {
"id": "C0035544",
"name": "ribonucleoproteins",
"pos": [
63,
81
]
} | {
"id": "C0085177",
"name": "rna binding",
"pos": [
109,
120
]
} |
immunolocalizations using anti-topollmt antibodies show the enzyme to be present in close association with the mitochondrial dna networks ( kinetoplast dna or kdna ) . | NA | {
"id": "C0012929",
"name": "mitochondrial dna",
"pos": [
111,
128
]
} | {
"id": "C0064360",
"name": "kinetoplast dna",
"pos": [
140,
155
]
} |
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