text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the development of monoclonal antibodies against antigens associated preferentially with human tumors has reawakened interest in the use of antibodies as site-specific targeting agents for cancer therapy . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
19,
40
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
140,
150
]
} |
by contrast , the depurination of 7-alkylguanine was 15 times slower in the single-stranded dna and 55 times slower in the double-stranded dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
76,
95
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
123,
142
]
} |
s- ( 2,5-dihydroxyphenyl ) -cysteine and s- ( 2,5-dihydroxyphenyl ) -n-acetyl-cysteine [ the cysteine- and n-acetyl-cysteine adducts , respectively , of hydroquinone ( hq ) ] were identified and quantified in the urine of mice administered [ ring-u-14c ] acetaminophen [ 14c ] apap , 200 mg kg-1 , i.p . ) . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
28,
36
]
} | {
"id": "C0001047",
"name": "n-acetyl-cysteine",
"pos": [
107,
124
]
} |
comparison of alfentanil , fentanyl and enflurane as supplements to general anaesthesia for outpatient gynaecologic surgery . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
14,
24
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
27,
35
]
} |
all patients received droperidol 0.625 mg iv , thiopentone and 70 per cent n2o in o2 plus either alfentanil ( 15 micrograms.kg-1 ) , fentanyl ( 1.5 microgram.kg-1 ) or enflurane . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
97,
107
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
133,
141
]
} |
recovery was significantly faster in the group receiving alfentanil , with the time to respond to verbal commands and the time to establish alertness significantly faster than with either fentanyl or enflurane . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
57,
67
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
188,
196
]
} |
in 2 more advanced ll-cases , nervous parenchyme was severely reduced , in a borderline lepromatous ( bl ) case obviously in part caused by cell infiltrates and granulomata . | NA | {
"id": "C0023348",
"name": "ll",
"pos": [
19,
21
]
} | {
"id": "C1562585",
"name": "borderline lepromatous",
"pos": [
77,
99
]
} |
intact and degenerating bacteria mostly in phagosomes of schwann cells associated with unmyelinated axons and in macrophages were seen only in the early ll- and the bl-case . | NA | {
"id": "C0023348",
"name": "ll",
"pos": [
67,
69
]
} | {
"id": "C1562585",
"name": "bl",
"pos": [
165,
167
]
} |
the seven tests reviewed in greatest detail include sodium-lithium countertransport , intraerythrocytic sodium , sodium ( or lithium ) -potassium cotransport , lithium leak , sodium-potassium atpase pump , sodium pump sites ( ouabain binding ) , and circulating sodium pump inhibitor ( 'digoxin-like factor ' in some stu... | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
192,
198
]
} | {
"id": "C0001479",
"name": "sodium pump",
"pos": [
262,
273
]
} |
these results indicate that malotilate may have inducible effects on hepatic drug metabolizing enzymes , and that it affects the various cytochrome p-450 isozymes from different strains of rat in different ways . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
95,
102
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
154,
162
]
} |
there are four parts : ( 1 ) inhibition by intracellular sugar phosphates in staphylococcus aureus , ( 2 ) pts-mediated regulation of glycerol uptake in bacillus subtilis , ( 3 ) competition for phospho-hpr in streptococcus mutans , and ( 4 ) the possible involvement of protein kinases in the regulation of sugar uptake... | NA | {
"id": "C0038655",
"name": "sugar phosphates",
"pos": [
57,
73
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
308,
313
]
} |
patients who use nph human insulin should be aware of this phenomenon and carefully inspect their vials for evidence of insulin precipitation before each injection . | NA | {
"id": "C0795633",
"name": "nph human",
"pos": [
17,
26
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
120,
127
]
} |
comparison of the fish p450ia1 protein with human , mouse , rat and rabbit p450ia1 and p450ia2 proteins reveals the presence of a remarkably large number of single amino acids and stretches of 2-6 residues in a row that are invariant among these nine p450 proteins . | NA | {
"id": "C0598294",
"name": "fish",
"pos": [
18,
22
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
256,
264
]
} |
in an effort to determine the effects of bicarbonate ( nahco3 ) ingestion on exercise performance , ten male college swimmers were studied during five different trials . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
41,
52
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
55,
61
]
} |
blood lactate , ph , sbc and be were significantly higher ( p less than 0.05 ) at post-exercise in nahco3 treatments . | NA | {
"id": "C0005367",
"name": "sbc",
"pos": [
21,
24
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
99,
105
]
} |
some 3'- and/or 5'-substituted pyrimidine nucleosides , as well as anhydropyrimidine nucleosides , which have no flexibility about the n-glycosidic bond were studied as inhibitors of thymidine phosphorylase and uridine phosphorylase . | NA | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
31,
53
]
} | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
85,
96
]
} |
the holoenzyme of lipoamide dehydrogenase can be reconstituted while the apoprotein is still bound to the column or the apoenzyme can be isolated in the free state . | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
73,
83
]
} | {
"id": "C0003589",
"name": "apoenzyme",
"pos": [
120,
129
]
} |
the measured affinity constants of the purified mitochondrial enzyme for methionine and trna ( met ) are similar to those of the cytoplasmic isoenzyme . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
62,
68
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
141,
150
]
} |
using limiting dilution analysis , we investigated proliferative responses of uchl1+ and uchl1- t cell populations to compare the precursor cell frequencies following recall and alloantigen stimulation , and the complexity of cellular interactions within uchl1+ and uchl1- populations . | NA | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
130,
144
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
226,
234
]
} |
however , cd2 adhesion was not necessary for ctl-mediated killing of allogeneic target cells , since t19+ cells generated in bulk mixed lymphocyte culture were extremely efficient at killing appropriate target cells . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
69,
79
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
210,
215
]
} |
specific t cell proliferation was observed in short-term blood mononuclear cell cultures set up from epstein-barr virus ( ebv ) -immune individuals and challenged either with uv-irradiated eb virions or with a candidate subunit vaccine preparation , the purified envelope glycoprotein gp340 incorporated into immune stim... | NA | {
"id": "C0887892",
"name": "subunit vaccine",
"pos": [
220,
235
]
} | {
"id": "C0085408",
"name": "iscoms",
"pos": [
346,
352
]
} |
all hybridoma antibodies were found to be of igm isotype , bearing the lambda light chain typical for alpha ( 1-3 ) dex-specific antibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
14,
24
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
49,
56
]
} |
the strong proliferative responses of mhm6+ cells seen in the presence of anti-igm ( alpha mu ) and interleukin 4 ( il4 ) or the cdw40 mab g28-5 , and with staphylococcus aureus cowan i ( sac ) , and to a lesser extent with the phorbol ester 12-o-tetradecanoylphorbol 13-acetate ( tpa ) , resemble that seen among unfrac... | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
228,
241
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
242,
278
]
} |
the cells maintained on the pa6 layer , however , contained the precursor cells giving rise to mature b cells when transferred to the st2 layer . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
4,
9
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
64,
79
]
} |
a monoclonal antibody ( mab ) g-5-2 was isolated which binds to transformed as well as normal cells of the b lineage but not to cells of the t cell , myeloid lineages nor to fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
94,
99
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
174,
185
]
} |
monoclonal antibodies produced against a crude toxic extract of a killer yeast ( pichia anomala ucsc 25f ) active against a large number of microorganisms were used to carry out a serological study on metabolic products of various yeasts with known and unknown genetic determinants of their killer characteristics . | NA | {
"id": "C0873195",
"name": "extract",
"pos": [
53,
60
]
} | {
"id": "C0043393",
"name": "yeasts",
"pos": [
231,
237
]
} |
complex ii of ascaris suum mitochondria , which functions as fumarate reductase in physiological conditions , contains three types of iron-sulfur clusters . | NA | {
"id": "C0283592",
"name": "complex ii",
"pos": [
0,
10
]
} | {
"id": "C0038615",
"name": "fumarate reductase",
"pos": [
61,
79
]
} |
a new assay ( label transfer from dna to protein ) enabled the identification of a terminal protein ( tp ) in nucleoprotein complexes extracted from cells infected with the parvovirus , minute virus of mice , mvm . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
41,
48
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
110,
123
]
} |
somatostatin-induced 86rb+ efflux is abolished by the hypoglycemia-inducing sulfonylurea , glibenclamide , a known blocker of atp-regulated k+ channels . | NA | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
76,
88
]
} | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
91,
104
]
} |
the duration of neonatal suppressor cell activity can be significantly prolonged by treating newborn rats with exogenous prostaglandin e2 ( pge2 ) , and the suppression was completely abolished by administration of pge inhibitor indomethacin . | NA | {
"id": "C0012472",
"name": "prostaglandin e2",
"pos": [
121,
137
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
215,
218
]
} |
a recent report of serum methotrexate ( mtx ) levels measured during treatment of gestational trophoblastic neoplasia ( gtn ) led us to determine mtx and human chorionic gonadotropin ( beta-hcg ) levels in a patient with low-risk metastatic gtn with a pulmonary metastasis . | NA | {
"id": "C0018062",
"name": "human",
"pos": [
154,
159
]
} | {
"id": "C0106132",
"name": "beta-hcg",
"pos": [
185,
193
]
} |
bioassays for msh in the hplc fractions revealed the existence of presumptive beta msh in both the pituitary and hypothalamus . | NA | {
"id": "C0026667",
"name": "msh",
"pos": [
14,
17
]
} | {
"id": "C0005261",
"name": "beta msh",
"pos": [
78,
86
]
} |
human chorionic gonadotropin and other gonadotropin preparations induced gvbd of croaker oocytes in vitro which indicates that the maturational steroid is of ovarian origin . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotropin",
"pos": [
0,
28
]
} | {
"id": "C0018061",
"name": "gonadotropin preparations",
"pos": [
39,
64
]
} |
the presence and distribution of immunoreactive calcitonin ( ict ) in the anuran ( rana pipiens ) ultimobranchial gland was examined with a specific antiserum to salmon calcitonin . | NA | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
48,
58
]
} | {
"id": "C0073994",
"name": "salmon calcitonin",
"pos": [
162,
179
]
} |
most cyclic antidepressants have a quinidinelike effect on the heart , which , in combination with type i antiarrhythmic agents such as quinidine , disopyramide and procainamide , may induce heart block and potentially lethal arrhythmias in susceptible individuals . | NA | {
"id": "C0018794",
"name": "heart block",
"pos": [
191,
202
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
226,
237
]
} |
the segregation of x-linked markers ( alpha gal , pgk-1 , hprt and g6pd ) was analysed in hybrids between gamma ray-irradiated mink fibroblasts and chinese hamster cells , or between mink cells and mouse hepatoma cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
132,
143
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
213,
218
]
} |
after dna sequencing a complex organized length heterogeneous 5 ' external spacer built up of different numbers of 340 bp subrepeats , each flanked by 52 bp direct repeats , is detected and described for the first time for plant ribosomal dna repeating units . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
6,
9
]
} | {
"id": "C0242964",
"name": "plant",
"pos": [
223,
228
]
} |
this transcript encodes a protein that contains a highly acidic region and 12 repeats of the 'zn finger ' domain characteristic of some dna-binding and transcription-activating proteins , supporting the hypothesis that the su ( hw ) locus might encode a transcription factor that plays a role in the expression of the gy... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
177,
185
]
} | {
"id": "C0040648",
"name": "transcription factor",
"pos": [
254,
274
]
} |
about 10 to 15 % of the major proteins are translated from mrnas that contain the spliced leader , among them two ribosomal proteins , ubiquitin , gapdh , a heat shock protein ( hsp70a ) , and three actins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
30,
38
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
114,
132
]
} |
to further study the immunology of insect hypersensitivity , we identified and partially characterized the principal allergens in whole body german cockroach ( wbgcr ) ( blattella germanica ) and compared this extract to whole body antigens prepared from other insects . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
117,
126
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
232,
240
]
} |
thus , increased levels of iga antibodies to dietary protein antigens in childhood coeliac disease were observed only within the iga1 isotype . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
31,
41
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
134,
141
]
} |
sera from autoimmune diseases including systemic lupus erythematosus , dermatomyositis , progressive systemic sclerosis and sjogren 's disease , were examined for reactivity against human c-myc oncogene product . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
10,
29
]
} | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
40,
68
]
} |
no significant correlation between the presence of the anti-c-myc product antibody and disease activity , clinical disease types and other autoantibodies such as antinuclear factor , anti-dna antibody , anti-rnp antibody and anti-sm antibody were shown in this study . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
139,
153
]
} | {
"id": "C0003243",
"name": "antinuclear factor",
"pos": [
162,
180
]
} |
different modulating effects of the monoamines adrenaline , noradrenaline , and serotonin on the dna synthesis response of human peripheral blood t lymphocytes activated by mercuric chloride and nickel sulfate . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
47,
57
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
60,
73
]
} |
the influence of adrenaline , noradrenaline , and serotonin ( 5-hydroxytryptamine ) was tested on the proliferative response of peripheral blood t lymphocytes of nickel-allergic subjects to mercuric chloride and nickel sulfate . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
17,
27
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
30,
43
]
} |
in the current study we employed two monoclonal antibodies , differing only in their functional affinity ( high ; k = 2.1 x 10 ( 8 ) /m and low ; k = 6.2 x 10 ( 6 ) /m ) to a common ligand found on the renal basement membrane , to evaluate whether a standard elution technique might selectively facilitate the removal of... | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
37,
58
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
325,
333
]
} |
the findings of the present study which were based upon quantitative 3h-thymidine autoradiography as well as upon determination of 3h-thymidine incorporation suggest that in vitro corticosteroid hormone depresses pre-chondroblasts proliferation along with an interference in the normal differentiative pathway of the abo... | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
180,
194
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
195,
202
]
} |
groups differed in fetal body weight , metabolic body weight , crown-to-rump length , placental weight , metabolic placental weight and placental surface area , respectively . | NA | {
"id": "C0751992",
"name": "fetal body weight",
"pos": [
19,
36
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
125,
131
]
} |
the majority of strains were also resistant to tetracycline , sulphamethoxazole and trimethoprim , but susceptible to co-trimoxazole , erythromycin , spectinomycin , ceftriaxone , ceftizoxime , cefodizime , ciprofloxacin , fleroxacin , rifampicin , rifabutin and fce 22250 . | NA | {
"id": "C0038689",
"name": "sulphamethoxazole",
"pos": [
62,
79
]
} | {
"id": "C0041044",
"name": "co-trimoxazole",
"pos": [
118,
132
]
} |
the majority of strains were also resistant to tetracycline , sulphamethoxazole and trimethoprim , but susceptible to co-trimoxazole , erythromycin , spectinomycin , ceftriaxone , ceftizoxime , cefodizime , ciprofloxacin , fleroxacin , rifampicin , rifabutin and fce 22250 . | NA | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
207,
220
]
} | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
223,
233
]
} |
the in-vitro activity of a new oral carbacephem , ly163892 , was compared with cefaclor , cephalexin , cephradine , cefadroxil and selected penicillins against 529 bacterial isolates . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
79,
87
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
90,
100
]
} |
the in-vitro activity of a new oral carbacephem , ly163892 , was compared with cefaclor , cephalexin , cephradine , cefadroxil and selected penicillins against 529 bacterial isolates . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
90,
100
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
103,
113
]
} |
the in-vitro activity of a new oral carbacephem , ly163892 , was compared with cefaclor , cephalexin , cephradine , cefadroxil and selected penicillins against 529 bacterial isolates . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
90,
100
]
} | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
116,
126
]
} |
roxithromycin has improved pharmacokinetic properties and may be a useful alternative agent for infections where erythromycin is indicated . | NA | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
0,
13
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
113,
125
]
} |
in this study , we have compared the therapeutic effects of fleroxacin with those of ofloxacin , norfloxacin , ciprofloxacin , pipemidic acid and cefaclor against pneumonia in mice caused by klebsiella pneumoniae . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
60,
70
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
111,
124
]
} |
the activity of fleroxacin was comparable with that of ofloxacin , pefloxacin and norfloxacin , but less than that of ciprofloxacin . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
16,
26
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
118,
131
]
} |
by june 1987 worldwide investigators from 37 centres in 12 countries had completed epidemiological susceptibility testing studies comparing the in-vitro activity of fleroxacin with that of ciprofloxacin , norfloxacin and other antibacterials . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
165,
175
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
189,
202
]
} |
the activity of fleroxacin and norfloxacin was quite similar , but was usually inferior to that of ciprofloxacin . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
16,
26
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
99,
112
]
} |
susceptibilities of methicillin-resistant staphylococcus aureus ( mrsa , n = 32 ) , methicillin-sensitive s. aureus ( mssa , n = 32 ) , and s. epidermidis ( se , n = 24 ) were determined to fleroxacin , amifloxacin , ciprofloxacin , difloxacin , enoxacin , norfloxacin , and ofloxacin . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
190,
200
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
217,
230
]
} |
mrsa and mssa mic90s were less than 1.0 mg/l of fleroxacin , ciprofloxacin , difloxacin , and ofloxacin while amifloxacin and norfloxacin produced mic90s of less than 2.0 mg/l and enoxacin mic90s of less than 4.0 mg/l . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
48,
58
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
61,
74
]
} |
the susceptibility of 11 clinical isolates of mycobacterium tuberculosis , 3 m. kansasii , 3 m. xenopi , 2 m. scrofulaceum , 2 m. marinum , 2 m. malmoense to fleroxacin , ciprofloxacin , norfloxacin , rifampicin , isoniazid , ethambutol , and streptomycin was determined by the standard proportion method ( middlebrook 7... | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
158,
168
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
171,
184
]
} |
all m. tuberculosis , m. kansasii , m. xenopi , m. scrofulaceum , m. marinum , and m , malmoense isolates including those resistant to conventional antimycobacterials were inhibited by 0.5 mg/l of fleroxacin and ciprofloxacin , the lowest tested concentration . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
197,
207
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
212,
225
]
} |
fleroxacin and ciprofloxacin along with ofloxacin , pefloxacin , ansamycin , clofazimine and cycloserine were also tested against 14 isolates of the m. avium complex . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
0,
10
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
15,
28
]
} |
fleroxacin and ciprofloxacin along with ofloxacin , pefloxacin , ansamycin , clofazimine and cycloserine were also tested against 14 isolates of the m. avium complex . | NA | {
"id": "C0140575",
"name": "ansamycin",
"pos": [
65,
74
]
} | {
"id": "C0035609",
"name": "14",
"pos": [
130,
132
]
} |
the potency of cytotoxicity increased in the order fleroxacin less than nalidixic acid less than ofloxacin less than norfloxacin less than ciprofloxacin . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
51,
61
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
139,
152
]
} |
against these bacteria , the activity of fleroxacin was roughly comparable to that of norfloxacin , enoxacin , ny-198 , and ofloxacin , but slightly less than that of ciprofloxacin . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
41,
51
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
167,
180
]
} |
the protective effects of a single oral dose of fleroxacin in mice were greater than those of norfloxacin and comparable to or greater than that of ciprofloxacin , ofloxacin and ny-198 against systemic infections with staphylococcus aureus , esch . coli and ps . aeruginosa , and serratia marcescens . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
48,
58
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
148,
161
]
} |
it is dissociated from actin filaments by atp , it is similar in size ( 200 kd ) to other myosins , and antibodies directed against dictyostelium myosin heavy chain bind to it . | NA | {
"id": "C0027096",
"name": "myosins",
"pos": [
90,
97
]
} | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
146,
164
]
} |
it is converted to its active form , factor xa , after specific cleavage by other plasma proteases or the protease from russel 's viper venom . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
89,
98
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
106,
114
]
} |
the factor x and factor xa activities were well separated from each other on a wide-pore diphenyl column ( whatman protesil 300 ) in less than 30 min . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
4,
12
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
17,
26
]
} |
both factor x and factor xa activities were found to be essentially unaffected by the solvent system . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
5,
13
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
18,
27
]
} |
this system was used to evaluate the purity of several factor x and factor xa preparations . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
55,
63
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
68,
77
]
} |
the kinetics of the russel 's viper venom catalyzed conversion of factor x to factor xa was also studied by using this chromatography system . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
66,
74
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
78,
87
]
} |
a time-dependent decrease in the protein peak corresponding to factor x and a corresponding increase in the factor xa protein peak was observed upon incubation with russel 's viper venom . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
63,
71
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
108,
117
]
} |
supercoiled ( form i ) plasmid dna molecules were readily separated from single-stranded circular dna of the same length and from various dna conformational isomers including nicked ( form ii ) and linear ( form iii ) species . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
73,
88
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
138,
141
]
} |
the blood shunts from the internal carotid to the cavernous sinus resulting in pulsating exophthalmos , orbital headache , pain , orbital or frontal bruit , loss of visual acuity , diplopia , ophthalmoplegia and the differential diagnosis should include superior orbital fissure syndrome , orbital apex syndrome and cave... | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
112,
120
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
123,
127
]
} |
synthesis and secretion of milk proteins ( alpha-casein , beta-casein , gamma-casein , and transferrin ) by cultured primary mouse mammary epithelial cells is modulated by the extracellular matrix . | NA | {
"id": "C0026138",
"name": "milk proteins",
"pos": [
27,
40
]
} | {
"id": "C0007332",
"name": "casein",
"pos": [
78,
84
]
} |
in a randomized , double-blind , parallel-group trial , 47 children with acute asthma received a combination of ipratropium bromide solution ( 250 micrograms ) and fenoterol hydrobromide solution ( 625 micrograms ) , fenoterol solution ( 625 micrograms ) alone , or ipratropium solution ( 250 micrograms ) alone , admini... | NA | {
"id": "C0700580",
"name": "ipratropium bromide",
"pos": [
112,
131
]
} | {
"id": "C0027235",
"name": "ipratropium",
"pos": [
266,
277
]
} |
we evaluated three individuals with work-related symptoms of asthma , rhinitis , conjunctivitis , urticaria , and angioedema on exposure to the insect . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
98,
107
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
114,
124
]
} |
the igg antibody to both antigens was specific for new antigenic determinants and not for the tm hapten . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
55,
77
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
97,
103
]
} |
the relationship of serum iga concentration to human immunodeficiency virus ( hiv ) infection : a cross-sectional study of hiv-seropositive individuals detected by screening in the united states air force . | NA | {
"id": "C0019693",
"name": "human immunodeficiency virus",
"pos": [
47,
75
]
} | {
"id": "C0019699",
"name": "hiv-seropositive",
"pos": [
123,
139
]
} |
therefore , patients who from the outset of their hiv infection or aids are known to have antibodies to t. gondii should be considered at risk for development of toxoplasmic encephalitis . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
50,
63
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
67,
71
]
} |
between 1985 and 1987 there were marked increases of children with aids , of hiv antibody-positive children of infected/at-risk mothers and of reported hiv infections in women of child-bearing age . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
67,
71
]
} | {
"id": "C0019693",
"name": "hiv infections",
"pos": [
152,
166
]
} |
over 100 compounds could be differentiated , including noncannabinoids ( terpenes , alkanes ) as well as minor and major cannabinoids and their acids . | NA | {
"id": "C0039561",
"name": "terpenes",
"pos": [
73,
81
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
121,
133
]
} |
the stability of plasma lipids and apolipoproteins during the early postmortem period was studied by taking four duplicate blood samples from eight cadavers 2 , 6 , 12 , and 24 h after death . | NA | {
"id": "C0006629",
"name": "cadavers",
"pos": [
148,
156
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
185,
190
]
} |
the case of an adult male who died from autoerotic asphyxiation shortly after watching a television show that discussed sexual asphyxiation is reported . | NA | {
"id": "C0011065",
"name": "died",
"pos": [
30,
34
]
} | {
"id": "C0004044",
"name": "asphyxiation",
"pos": [
127,
139
]
} |
cells were shown to transport pi by a 4,4'-dinitro stilbene-2,2'-disulfonate ( dnds ) -sensitive pathway ( 75 % ) , a newly discovered sodium-phosphate ( na/pi ) cotransport pathway ( 20 % ) , and a pathway linearly dependent on an extracellular phosphate concentration of up to 2.0 mm ( 5 % ) . | NA | {
"id": "C0074757",
"name": "sodium-phosphate",
"pos": [
135,
151
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
246,
255
]
} |
in contrast , the addition of the cl/hco3 exchange inhibitors h2 4,4'-diisothiocyanostilbene-2,2'-disulfonate ( dids ) or pentachlorophenol ( pcp ) causes a drop in intracellular ph , and the removal of extracellular chloride in the presence of bicarbonate leads to a large intracellular alkalinization , which indicates... | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
217,
225
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
336,
341
]
} |
however , acute hdv superinfection progressing to chronic hdv infection in two hepatitis b e antigen ( hbeag ) -positive hbv carriers and coinfection in two other patients who progressed to chronic hbv ( hbeag-positive ) and hdv infection was associated with continuing high-level hbv replication for several years . | NA | {
"id": "C0524909",
"name": "chronic hbv",
"pos": [
190,
201
]
} | {
"id": "C0019163",
"name": "hbv",
"pos": [
281,
284
]
} |
this model of hemorrhage should be useful for future study of the effects of treatment of hemorrhagic shock in immature subjects . | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
14,
24
]
} | {
"id": "C0036982",
"name": "hemorrhagic shock",
"pos": [
90,
107
]
} |
the methyl ester and some glycolamide esters of benzylpenicillin and ampicillin were shown to be rapidly degraded by human plasma at 37 degrees c with no parent penicillin being produced . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
48,
64
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
69,
79
]
} |
the plasma-catalysed degradation which was also observed in rat plasma proceeds most likely through hydrolytic cleavage of the beta-lactam bonds of the penicillin esters and is suggested to be due to the presence of an ester-specific beta-lactamase in plasma . | NA | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
127,
138
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
152,
162
]
} |
the results show that the failure of simple alkyl esters of penicillins to function as prodrugs is not due to a high enzymatic stability of the esters , as widely believed , but rather to a pronounced susceptibility to undergo hydrolytic cleavage of their beta-lactam ring in-vivo . | NA | {
"id": "C0030842",
"name": "penicillins",
"pos": [
60,
71
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
256,
267
]
} |
since double ester prodrugs of penicillins , such as the pivaloyloxymethyl ester of ampicillin , are readily hydrolysed in plasma to yield the parent penicillin although at a rate lower than e.g . that of inactivation of a simple methyl ester , the plasma enzyme apparently attacking the beta-lactam bond of penicillin e... | NA | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
288,
299
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
308,
318
]
} |
the pharmacological activity of the cardiotonic agents amrinone and milrinone has been examined on the isolated guinea-pig ileum . | NA | {
"id": "C0002697",
"name": "amrinone",
"pos": [
55,
63
]
} | {
"id": "C0128513",
"name": "milrinone",
"pos": [
68,
77
]
} |
higher concentrations of amrinone or milrinone produced contractions of the ileum which were prevented by atropine . | NA | {
"id": "C0002697",
"name": "amrinone",
"pos": [
25,
33
]
} | {
"id": "C0128513",
"name": "milrinone",
"pos": [
37,
46
]
} |
it is concluded that amrinone and milrinone can antagonise some effects of purines but this does not represent their only pharmacological action . | NA | {
"id": "C0002697",
"name": "amrinone",
"pos": [
21,
29
]
} | {
"id": "C0128513",
"name": "milrinone",
"pos": [
34,
43
]
} |
blm showed first order plasma elimination kinetics over 30 min in both strains with a shorter half-life in the sensitive strain ( 9.6 +/- 0.3 min in c57bl/6n vs. 12.7 +/- 1.9 min in balb/c ) . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
42,
50
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
94,
103
]
} |
additional studies with other adenosine analogs , such as 5'-n-ethyl-carboxamine adenosine , r-n6-phenylisopropyladenosine , s-n6-phenylisopropyladenosine and n6-cyclohexyladenosine , indicate that the p1-receptor is of the a1 subtype . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
30,
39
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
130,
154
]
} |
first administered 30 min after the induction of ischemia , sl 82.0715 ( 1 and 10 mg/kg p.o . ) reduced infarction volume by 34 and 48 % , respectively . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
49,
57
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
104,
114
]
} |
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